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Conserved domains on  [gi|759423257|ref|WP_043146917|]
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MULTISPECIES: (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase [Serratia]

Protein Classification

antibiotic biosynthesis monooxygenase family protein( domain architecture ID 10013541)

antibiotic biosynthesis monooxygenase family protein may be involved in the biosynthesis of several antibiotics; similar to Streptomyces ambofaciens anthrone oxidase-like protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10486 PRK10486
(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;
1-96 8.47e-69

(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;


:

Pssm-ID: 182494  Cd Length: 96  Bit Score: 200.34  E-value: 8.47e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759423257  1 MHVTLVEINVKQDKIDEFIDVFRANHRGAIEEPGNLRFDVLQDEQIPTRFYIYEAYRDEQAVAAHKQTPHYLQCVEKLEA 80
Cdd:PRK10486  1 MHVTLVEINVKEDKVDEFIEVFRQNHLGSIQEPGNLRFDVLQDPEVPTRFYIYEAYKDEAAVAFHKTTPHYKTCVEKLEP 80

                        90
                ....*....|....*.
gi 759423257 81 LMTGPRKKTTFIGLMP 96
Cdd:PRK10486 81 LMTGPRKKRLFIGLMP 96
 
Name Accession Description Interval E-value
PRK10486 PRK10486
(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;
1-96 8.47e-69

(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;


Pssm-ID: 182494  Cd Length: 96  Bit Score: 200.34  E-value: 8.47e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759423257  1 MHVTLVEINVKQDKIDEFIDVFRANHRGAIEEPGNLRFDVLQDEQIPTRFYIYEAYRDEQAVAAHKQTPHYLQCVEKLEA 80
Cdd:PRK10486  1 MHVTLVEINVKEDKVDEFIEVFRQNHLGSIQEPGNLRFDVLQDPEVPTRFYIYEAYKDEAAVAFHKTTPHYKTCVEKLEP 80

                        90
                ....*....|....*.
gi 759423257 81 LMTGPRKKTTFIGLMP 96
Cdd:PRK10486 81 LMTGPRKKRLFIGLMP 96
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
3-91 3.61e-25

Quinol monooxygenase YgiN [Energy production and conversion];


Pssm-ID: 440970  Cd Length: 91  Bit Score: 90.01  E-value: 3.61e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759423257  3 VTLVEINVKQDKIDEFIDVFRANHRGAIEEPGNLRFDVLQDEQIPTRFYIYEAYRDEQAVAAHKQTPHYLQCVEKLEALM 82
Cdd:COG1359   2 TVIAKLTVKPGKRDEFLAALRELVEATRAEPGCLSYELYRDPDDPNRFVLYERWEDEAALEAHLASPHFKAFLAALAPLL 81


                ....*....
gi 759423257 83 TGPRKKTTF 91
Cdd:COG1359  82 AEPPEVRVY 90
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 5-75 2.21e-19

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 74.61  E-value: 2.21e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 759423257   5 LVEINVKQDKIDEFIDVFRANHRGAIEEPGNLRFDVLQDEQIPTRFYIYEAYRDEQAVAAHKQTPHYLQCV 75
Cdd:pfam03992  4 VAEIRVKPGKAEEFEEALAELVEATRNEPGCLSYELLRSLEDPDEYVVLEVWEDEAAFEAHLQSPHFKAAH 74
 
Name Accession Description Interval E-value
PRK10486 PRK10486
(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;
1-96 8.47e-69

(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;


Pssm-ID: 182494  Cd Length: 96  Bit Score: 200.34  E-value: 8.47e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759423257  1 MHVTLVEINVKQDKIDEFIDVFRANHRGAIEEPGNLRFDVLQDEQIPTRFYIYEAYRDEQAVAAHKQTPHYLQCVEKLEA 80
Cdd:PRK10486  1 MHVTLVEINVKEDKVDEFIEVFRQNHLGSIQEPGNLRFDVLQDPEVPTRFYIYEAYKDEAAVAFHKTTPHYKTCVEKLEP 80

                        90
                ....*....|....*.
gi 759423257 81 LMTGPRKKTTFIGLMP 96
Cdd:PRK10486 81 LMTGPRKKRLFIGLMP 96
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
3-91 3.61e-25

Quinol monooxygenase YgiN [Energy production and conversion];


Pssm-ID: 440970  Cd Length: 91  Bit Score: 90.01  E-value: 3.61e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759423257  3 VTLVEINVKQDKIDEFIDVFRANHRGAIEEPGNLRFDVLQDEQIPTRFYIYEAYRDEQAVAAHKQTPHYLQCVEKLEALM 82
Cdd:COG1359   2 TVIAKLTVKPGKRDEFLAALRELVEATRAEPGCLSYELYRDPDDPNRFVLYERWEDEAALEAHLASPHFKAFLAALAPLL 81


                ....*....
gi 759423257 83 TGPRKKTTF 91
Cdd:COG1359  82 AEPPEVRVY 90
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 5-75 2.21e-19

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 74.61  E-value: 2.21e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 759423257   5 LVEINVKQDKIDEFIDVFRANHRGAIEEPGNLRFDVLQDEQIPTRFYIYEAYRDEQAVAAHKQTPHYLQCV 75
Cdd:pfam03992  4 VAEIRVKPGKAEEFEEALAELVEATRNEPGCLSYELLRSLEDPDEYVVLEVWEDEAAFEAHLQSPHFKAAH 74
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 1-91 9.02e-07

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


Pssm-ID: 441901  Cd Length: 98  Bit Score: 43.06  E-value: 9.02e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759423257  1 MHVTLVEINVKQDKIDEFIDVFRANHRGAIEEPGNLRFDVLQDEQIPTRFYIYEAYRDEQAVAAHKQTPHYLQCVEKLEA 80
Cdd:COG2329   1 MIVVINRFRVKPGQEEEFEEAFAERRELLAEQPGFLGFELLRSLEDPGEYLVVSYWESEEAFRAWFRSSEHRAAHAKGRE 80

                        90
                ....*....|.
gi 759423257 81 LMTGPRKKTTF 91
Cdd:COG2329  81 ILAGPPRVEHY 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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