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Conserved domains on  [gi|763310756|ref|WP_044169244|]
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CsgG/HfaB family protein [Porphyromonas catoniae]

Protein Classification

CsgG/HfaB family protein( domain architecture ID 10003703)

CsgG/HfaB family protein similar to Caulobacter HfaB, which is involved in attachment of the holdfast, a polysaccharide complex adhesive organelle, to the cell, and to CsgG, a lipoprotein that forms a secretion channel for curli subunits, functional amyloids involved in biofilm formation, in the outer membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CsgG COG1462
Curli biogenesis system outer membrane secretion channel CsgG [Cell wall/membrane/envelope ...
 6-230 7.04e-49

Curli biogenesis system outer membrane secretion channel CsgG [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 441071 [Multi-domain]  Cd Length: 263  Bit Score: 163.65  E-value: 7.04e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763310756   6 ALIGVLLITGCST---SILYAQDPPRVVAQQ--GVDHHNIQPRGLKWKVAVGRFSNETQYGKGIFYDRandpMAKQALDI 80
Cdd:COG1462   11 LALLALLLAGCATtesSTPVEVEPPVLANATpyAQDLVALPYPGPKPRVAVGDFDDQTGQNGSSGSDA----VGQGASDM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763310756  81 LMAKLSASGKFILLERSDTDKLEAELK------------SGEGQKIGADYLILGSITEFGRKVTGKE------GLFSSEK 142
Cdd:COG1462   87 LITALQQSGRFTVVERENLSNLLAERKlagsgriragtaAQLGQLLGADYLITGGITEFDRNTSGGGggarlfGIGGSGK 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763310756 143 SQTVQAGVSIRIVDVTTGQVIYSEEAKGQAETTSKSTLGLG---------GKAGYDATLSDKAISGAIDQLVENIINKCT 213
Cdd:COG1462  167 YQVAYVTVDLRLVDVRTGEVVYSVTGSGEISSSEVSAGGFGfvggglleaGTGGYDNTPNGKAVRAAIEEAVNNLVAGLE 246

                        250
                 ....*....|....*..
gi 763310756 214 DKPWRTYVISADEDGII 230
Cdd:COG1462  247 AGAWRPADLAVSGGQVV 263
 
Name Accession Description Interval E-value
CsgG COG1462
Curli biogenesis system outer membrane secretion channel CsgG [Cell wall/membrane/envelope ...
 6-230 7.04e-49

Curli biogenesis system outer membrane secretion channel CsgG [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441071 [Multi-domain]  Cd Length: 263  Bit Score: 163.65  E-value: 7.04e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763310756   6 ALIGVLLITGCST---SILYAQDPPRVVAQQ--GVDHHNIQPRGLKWKVAVGRFSNETQYGKGIFYDRandpMAKQALDI 80
Cdd:COG1462   11 LALLALLLAGCATtesSTPVEVEPPVLANATpyAQDLVALPYPGPKPRVAVGDFDDQTGQNGSSGSDA----VGQGASDM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763310756  81 LMAKLSASGKFILLERSDTDKLEAELK------------SGEGQKIGADYLILGSITEFGRKVTGKE------GLFSSEK 142
Cdd:COG1462   87 LITALQQSGRFTVVERENLSNLLAERKlagsgriragtaAQLGQLLGADYLITGGITEFDRNTSGGGggarlfGIGGSGK 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763310756 143 SQTVQAGVSIRIVDVTTGQVIYSEEAKGQAETTSKSTLGLG---------GKAGYDATLSDKAISGAIDQLVENIINKCT 213
Cdd:COG1462  167 YQVAYVTVDLRLVDVRTGEVVYSVTGSGEISSSEVSAGGFGfvggglleaGTGGYDNTPNGKAVRAAIEEAVNNLVAGLE 246

                        250
                 ....*....|....*..
gi 763310756 214 DKPWRTYVISADEDGII 230
Cdd:COG1462  247 AGAWRPADLAVSGGQVV 263
CsgG pfam03783
Curli production assembly/transport component CsgG; CsgG is an outer membrane-located ...
 41-218 9.08e-25

Curli production assembly/transport component CsgG; CsgG is an outer membrane-located lipoprotein that is highly resistant to protease digestion. During curli assembly, an adhesive surface fibre, CsgG is required to maintain the stability of CsgA and CsgB.


Pssm-ID: 427502  Cd Length: 209  Bit Score: 99.01  E-value: 9.08e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763310756   41 QPRGlKWKVAVGRFSNETQYGKGIFYDRANDPMAKQALDILMAKLSASGKFILLERSDTDKLEAELKSGE---------- 110
Cdd:pfam03783   4 QPQG-KIRIAVYDFSNQTGQYKPQPNSSFSTAVGQGLSDMLVQALVKSGWFRVLEREGLQNLLTEQKLGRsgridpntaa 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763310756  111 --GQKIGADYLILGSITEFGRKV----TGKE--GLFSSEKSQTVQAGVSIRIVDVTTGQVIYSEEAKGQAETTSKSTLG- 181
Cdd:pfam03783  83 qlGKLTGADYLVEGSITAYDTNVstggGGARylGIGASSKYREAQVAVDLRLVDVRTGEVLASVTGTGTSSSSEARAGVf 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 763310756  182 -------LGGKAGY-DATLSDKAISGAIDQLVENIINKCTDKPWR 218
Cdd:pfam03783 163 rfigkglLGGEAGStSNEPVGLAVRAAIEQAVKYLITGIERGAWL 207
PRK15184 PRK15184
curli production assembly/transport protein CsgG; Provisional
 1-230 5.96e-07

curli production assembly/transport protein CsgG; Provisional


Pssm-ID: 185106 [Multi-domain]  Cd Length: 277  Bit Score: 50.04  E-value: 5.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763310756   1 MKTLKALIGVLLITGCSTSilyaqdPPRVVAQQgvdhhNIQPRGLKWK-------------VAVGRFSNETqyGKGIFYD 67
Cdd:PRK15184   1 MQRLFLLVAVMLLSGCLTA------PPKEAARP-----TLMPRAQSYKdlthlpaptgkifVSVYNIQDET--GQFKPYP 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763310756  68 RANDPMA--KQALDILMAKLSASGKFILLERSDTDKLEAELK----SGEGQKIG------------ADYLILGSITEFGR 129
Cdd:PRK15184  68 ASNFSTAvpQSATAMLVTALKDSRWFIPLERQGLQNLLNERKiiraAQENGTVAinnriplqsltaANIMVEGSIIGYES 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763310756 130 KV----TGKE--GLFSSEKSQTVQAGVSIRIVDVTTGQVIYSeeakgqaETTSKSTLGLGGKAGydatlsdkaISGAID- 202
Cdd:PRK15184 148 NVksggVGARyfGIGADTQYQLDQIAVNLRVVNVSTGEILSS-------VNTSKTILSYEVQAG---------VFRFIDy 211

                        250       260
                 ....*....|....*....|....*....
gi 763310756 203 -QLVENIINKCTDKPWRTYVISADEDGII 230
Cdd:PRK15184 212 qRLLEGEVGYTSNEPVMLCLMSAIETGVI 240
 
Name Accession Description Interval E-value
CsgG COG1462
Curli biogenesis system outer membrane secretion channel CsgG [Cell wall/membrane/envelope ...
 6-230 7.04e-49

Curli biogenesis system outer membrane secretion channel CsgG [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441071 [Multi-domain]  Cd Length: 263  Bit Score: 163.65  E-value: 7.04e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763310756   6 ALIGVLLITGCST---SILYAQDPPRVVAQQ--GVDHHNIQPRGLKWKVAVGRFSNETQYGKGIFYDRandpMAKQALDI 80
Cdd:COG1462   11 LALLALLLAGCATtesSTPVEVEPPVLANATpyAQDLVALPYPGPKPRVAVGDFDDQTGQNGSSGSDA----VGQGASDM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763310756  81 LMAKLSASGKFILLERSDTDKLEAELK------------SGEGQKIGADYLILGSITEFGRKVTGKE------GLFSSEK 142
Cdd:COG1462   87 LITALQQSGRFTVVERENLSNLLAERKlagsgriragtaAQLGQLLGADYLITGGITEFDRNTSGGGggarlfGIGGSGK 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763310756 143 SQTVQAGVSIRIVDVTTGQVIYSEEAKGQAETTSKSTLGLG---------GKAGYDATLSDKAISGAIDQLVENIINKCT 213
Cdd:COG1462  167 YQVAYVTVDLRLVDVRTGEVVYSVTGSGEISSSEVSAGGFGfvggglleaGTGGYDNTPNGKAVRAAIEEAVNNLVAGLE 246

                        250
                 ....*....|....*..
gi 763310756 214 DKPWRTYVISADEDGII 230
Cdd:COG1462  247 AGAWRPADLAVSGGQVV 263
CsgG pfam03783
Curli production assembly/transport component CsgG; CsgG is an outer membrane-located ...
 41-218 9.08e-25

Curli production assembly/transport component CsgG; CsgG is an outer membrane-located lipoprotein that is highly resistant to protease digestion. During curli assembly, an adhesive surface fibre, CsgG is required to maintain the stability of CsgA and CsgB.


Pssm-ID: 427502  Cd Length: 209  Bit Score: 99.01  E-value: 9.08e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763310756   41 QPRGlKWKVAVGRFSNETQYGKGIFYDRANDPMAKQALDILMAKLSASGKFILLERSDTDKLEAELKSGE---------- 110
Cdd:pfam03783   4 QPQG-KIRIAVYDFSNQTGQYKPQPNSSFSTAVGQGLSDMLVQALVKSGWFRVLEREGLQNLLTEQKLGRsgridpntaa 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763310756  111 --GQKIGADYLILGSITEFGRKV----TGKE--GLFSSEKSQTVQAGVSIRIVDVTTGQVIYSEEAKGQAETTSKSTLG- 181
Cdd:pfam03783  83 qlGKLTGADYLVEGSITAYDTNVstggGGARylGIGASSKYREAQVAVDLRLVDVRTGEVLASVTGTGTSSSSEARAGVf 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 763310756  182 -------LGGKAGY-DATLSDKAISGAIDQLVENIINKCTDKPWR 218
Cdd:pfam03783 163 rfigkglLGGEAGStSNEPVGLAVRAAIEQAVKYLITGIERGAWL 207
PRK15184 PRK15184
curli production assembly/transport protein CsgG; Provisional
 1-230 5.96e-07

curli production assembly/transport protein CsgG; Provisional


Pssm-ID: 185106 [Multi-domain]  Cd Length: 277  Bit Score: 50.04  E-value: 5.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763310756   1 MKTLKALIGVLLITGCSTSilyaqdPPRVVAQQgvdhhNIQPRGLKWK-------------VAVGRFSNETqyGKGIFYD 67
Cdd:PRK15184   1 MQRLFLLVAVMLLSGCLTA------PPKEAARP-----TLMPRAQSYKdlthlpaptgkifVSVYNIQDET--GQFKPYP 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763310756  68 RANDPMA--KQALDILMAKLSASGKFILLERSDTDKLEAELK----SGEGQKIG------------ADYLILGSITEFGR 129
Cdd:PRK15184  68 ASNFSTAvpQSATAMLVTALKDSRWFIPLERQGLQNLLNERKiiraAQENGTVAinnriplqsltaANIMVEGSIIGYES 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763310756 130 KV----TGKE--GLFSSEKSQTVQAGVSIRIVDVTTGQVIYSeeakgqaETTSKSTLGLGGKAGydatlsdkaISGAID- 202
Cdd:PRK15184 148 NVksggVGARyfGIGADTQYQLDQIAVNLRVVNVSTGEILSS-------VNTSKTILSYEVQAG---------VFRFIDy 211

                        250       260
                 ....*....|....*....|....*....
gi 763310756 203 -QLVENIINKCTDKPWRTYVISADEDGII 230
Cdd:PRK15184 212 qRLLEGEVGYTSNEPVMLCLMSAIETGVI 240
LpoB COG3417
Outer membrane lipoprotein LpoB, binds and activates PBP1b [Cell wall/membrane/envelope ...
 1-169 1.72e-05

Outer membrane lipoprotein LpoB, binds and activates PBP1b [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442643  Cd Length: 190  Bit Score: 44.53  E-value: 1.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763310756   1 MKTLK---ALIGVLLITGC-STSILYAQDPPRVVAQQGVDHHNIQ------------------PRGLKWKVAVGRFSNET 58
Cdd:COG3417    1 MKKKKlllVALAALLLAGCaSTPVTYVDPNEVEDVSGKWNSTDWQaaaepmvdsmlsspwvakTAGGRPVLLVDSVKNKT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763310756  59 qygkgifydraNDPM-AKQALDILMAKLSASGKFILLERSDTDKLEAELK-------------SGEGQKIGADYLILGSI 124
Cdd:COG3417   81 -----------NEHIdTETATKDIRRALINSGKFRFVSAGQLAQARQELGlqrddslvsrstaIGLGREVGADYVLYGSI 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 763310756 125 TefGRKVtgkeglfSSEKSQTVQAGVSIRIVDVTTGQVIYSEEAK 169
Cdd:COG3417  150 S--SIVD-------SPGKGKVVYYQFTLQLMDVQTGEIVWSGEKE 185
LpoB pfam13036
Peptidoglycan-synthase activator LpoB; This is a family of Gram-negative bacterial outer ...
 40-169 1.22e-04

Peptidoglycan-synthase activator LpoB; This is a family of Gram-negative bacterial outer membrane lipoproteins. LpoB is required for the function of the major peptidoglycan synthase enzyme PBP1B. It interacts with PBP1B protein via the UvrB-like non-catalytic domain on that protein. LpoB has a 54-aa-long flexible N-terminal stretch followed by a globular domain with similarity to the N-terminal domain of the prevalent periplasmic protein TolB. The long, flexible N-terminal region of LpoB enables it to span the periplasm and reach its docking site in PBP1B. Peptidoglycan is the essential polymer within the sacculus that surrounds the cytoplasmic membrane of bacteria.


Pssm-ID: 463777  Cd Length: 147  Bit Score: 41.52  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763310756   40 IQPRGLKWKVAVGRFSNETqygkgifydraNDPM-AKQALDILMAKLSASGKFILLERSDTDKLEAELK----------- 107
Cdd:pfam13036  23 LKADGKRPVLLVSDVKNDT-----------SEHIdTESLTDKIRRALIKSGKFRFVDGAQRQDAREELRlqqdsglvdqs 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 763310756  108 --SGEGQKIGADYLILGSITEFgRKVTGKEglfsseksQTVQAGVSIRIVDVTTGQVIYSEEAK 169
Cdd:pfam13036  92 taAKIGRLIGADYSLSGKINSI-VKAEGGE--------KVVYYQITLELTDVETGEIVWSGEKE 146
TolBN COG5616
TolB amino-terminal domain (function unknown) [Signal transduction mechanisms];
49-166 5.72e-03

TolB amino-terminal domain (function unknown) [Signal transduction mechanisms];


Pssm-ID: 444347  Cd Length: 135  Bit Score: 36.40  E-value: 5.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 763310756  49 VAVGRFSNETQygkgifyDRANDPMAKQALDILMAKLSASGKFILLERSDTDKLEAELKSGE--GQKIGADYLILGSITE 126
Cdd:COG5616   13 IAVLPFENLSG-------DPEQEYFADGLTEELITALSRLRGLRVIARTSSFAFKGRAVDLReiARELGVRYVLEGSVRR 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 763310756 127 FGRKVTgkeglfsseksqtvqagVSIRIVDVTTGQVIYSE 166
Cdd:COG5616   86 SGDRVR-----------------VTAQLIDAATGRHLWSE 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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