|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
17-377 |
9.25e-93 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 283.30 E-value: 9.25e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 17 PLLSLIILTLGSALLTTFLSLKLDSLNTSEFLIGGLTTAYYAGMVLGAFKLEGLILRVGHIRAYSAFASMLAVFSILHGF 96
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 97 YVDVYFWLLLRFLGGIATAGLYIVIESWILSATDNKNRGGSLALYMIALYVAQAGGQWLLNIGDQDTLILYCIAAVFASL 176
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 177 SVIPLALTRTTAPIFSEPETLSIGQMIKLSPSGVSTCFVSGMILGSIYGLYPIFIQNSGYPTAEISIIMGLTIFGGMVFQ 256
Cdd:cd17477 161 ALVPLLLTRRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 257 YPFGRLSDLISRRYVIAFLALMSSVLCVAIIeIGKDNVYIISILSFLLGGTTFCLYPIGISHTCDRINNNQIVSASQTLL 336
Cdd:cd17477 241 WPLGWLADRFDRRRVLLGCALLGALAALLLP-LVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALL 319
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 890045417 337 LSYGLGATFGPIIAPLFNIVMVDGEILVFIMVMSLPLCLFM 377
Cdd:cd17477 320 LLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| PRK03633 |
PRK03633 |
putative MFS family transporter protein; Provisional |
18-381 |
6.80e-51 |
|
putative MFS family transporter protein; Provisional
Pssm-ID: 179614 [Multi-domain] Cd Length: 381 Bit Score: 175.62 E-value: 6.80e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 18 LLSLIILTLGSALLTTFLSLKLDSLNTSEFLIGGLTTAYYAGMVLGAFKLEGLILRVGHIRAYSAFASMLAVFSILHGFY 97
Cdd:PRK03633 12 LCGLLLLTLAIAVLNTLVPLWLAQEHLPTWQVGVVSSSYFTGNLVGTLLAGYVIKRIGFNRSYYLASLIFAAGCAGLGLM 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 98 VDVYFWLLLRFLGGIATAGLYIVIESWILSATDNKNRGGSLALYMIALYVAQAGGQWLLNIGDQDTLILYCIAAVFASLS 177
Cdd:PRK03633 92 VGFWSWLAWRFVAGIGCAMIWVVVESALMCSGTSRNRGRLLAAYMMVYYLGTVLGQLLVSKVSTELMSVLPWVTGLVLAA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 178 VIPLALTRTTAPIFSEPETLSIGQMIKLSPS--GVSTCFVSGMILGSIYGLYPIFIQNSGYPTAEISIIMGLTIFGGMVF 255
Cdd:PRK03633 172 ILPLLFTRILNQQAENHDSTSIWPMLKLRQArlGVNGCIISGIVLGSLYGLMPLYLNHQGMSDASIGFWMALLVSAGILG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 256 QYPFGRLSDLISRRYVIAFLALMSSVLCVAIIeigkdNVYIISILSFLLGGTTFCLYPIGISHTCDRINNNQIVSASQTL 335
Cdd:PRK03633 252 QWPIGRLADRFGRLLVLRVQVFVVILGSIAML-----SQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHELVAMNQAL 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 890045417 336 LLSYGLGATFGPIIAPLFNIVMVDGeiLVFIMVMSLPLC-LFMLWRK 381
Cdd:PRK03633 327 LLSYTVGSLLGPSFTAMLMQNYSDN--LLFIMIASVSFIyLLMLLRK 371
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
18-344 |
1.56e-22 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 97.74 E-value: 1.56e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 18 LLSLIILTLGSALLTTFLSLKLDSLNTSEFLIGGLTTAYYAGMVLGAFKLEGLILRVGHIRAYSAFASMLAVFSILHGFY 97
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 98 VDVYFWLLLRFLGGIATAGLYIVIESWILSATDNKNRGGSLALYMIALYVAQAGGQ----WLLNIGDQDTLILycIAAVF 173
Cdd:COG2814 96 PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPllggLLADLFGWRWVFL--VNAVL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 174 ASLSVIPLALT-RTTAPIFSEPETLSIGQMIK--LSPSGVSTCFVSGMILGSIYGLYPIFIQN-SGYPTAEISIIMGLTI 249
Cdd:COG2814 174 ALLALLLLLRLlPESRPAARARLRGSLRELLRrpRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 250 FGGMVFQYPFGRLSDLISRRYVIAFLALMSSVLCVAIIEIGkdNVYIISILSFLLGGTTFCLYPIGISHTCDRINNNQIV 329
Cdd:COG2814 254 LGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG--SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARG 331
|
330
....*....|....*
gi 890045417 330 SASQTLLLSYGLGAT 344
Cdd:COG2814 332 RASGLYNSAFFLGGP 346
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
18-380 |
7.12e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 81.47 E-value: 7.12e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 18 LLSLIILTLGSALLTTFLSLKLDSLNTSEFLIGGLTTAYYAGMVLGAFKLEGLILRVGHIRAYSAFASMLAVFSILHGFY 97
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 98 VDVYFWLLLRFLGGIATAGLYIVIESWILSATDNKNRGGSLALYMIALYVAQAGG----QWLLNIGDQDTLILYCIAAVF 173
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGpllgGLLADALGYRAPFLVCAALAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 174 ASLSVIPLALTRTTAPIFSEPETLSIGQMIK---LSPSGVSTC----FVSGMILGSIYGLYPIFIQNS-GYPTAEISIIM 245
Cdd:cd17325 162 LALVLALLLLPEPRPPPNKRAVSAARLRSGLrllLRDRRLLALflaiFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 246 GLTIFGGMVFQYPFGRLSDLISRRYVIAFLALMSSVLCVAIIEIgkDNVYIISILSFLLGGTTFCLYPIGISHTCDRINN 325
Cdd:cd17325 242 GAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA--TSFWLLLLLLALLGLGLGLVFPATLALLADIVPP 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 890045417 326 NQIVSASQTLLLSYGLGATFGPIIAPLfnIVMVDGEILVFIMVMSLPL-CLFMLWR 380
Cdd:cd17325 320 EGRGTAMGLFNTAFSLGMVLGPLLGGF--LYDAFGFATPFLAAAALLLlAAVLFLL 373
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
18-347 |
8.17e-14 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 72.07 E-value: 8.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 18 LLSLIILTLGSALLTTFLSLKL-DSLNTSEFLIGGLTTAYYAGMVLGAFKLEGLILRVGHIRAYSAFASMLAVFSILHGF 96
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 97 YVDVYFWLLLRFLGGIATAGLYIVIESWILSATDNKNRGGSLALYMIALYVAQA----GGQWLLNIGDQDTLILYCIAAV 172
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAAlgplLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 173 FASLSVIPLALTRTTAPIFSEPETLSIGQMIKLS-------PSGVSTCFVSGMILGSIYGLYPIFIQNSGYPTAEISIIM 245
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKallrdpvLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 246 GLTIFGGMVFQYPFGRLSDLISRRYVIAFLALMSSVLCVAIIEIG-KDNVYIISILSFLLGGTTFCLYPIGISHTCDRIN 324
Cdd:pfam07690 242 GLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSlTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAP 321
|
330 340
....*....|....*....|...
gi 890045417 325 NNQIVSASQTLLLSYGLGATFGP 347
Cdd:pfam07690 322 KEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-379 |
7.81e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 66.30 E-value: 7.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 18 LLSLIILTLGSALLTTFLSLKLDSLNTSEFLIGGLTTAYYAGMVLGAFKLEGLILRVGHIRAYSAFASMLAVFSILHGFY 97
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 98 VDVYFWLLLRFLGGIATAGLYIVIESWILSATDNKNRGGSLALYMIALYVAQAGGQ----WLLNIGDQDTLILYCIAAVF 173
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPllggILASSLGFGWRAVFLIAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 174 ASLSVIPLALTRTTAP--------IFSEPETLSIGQMIKLSPSGVSTCFVSGMILGSIYG----LYPIFIQNSGYPTAEI 241
Cdd:cd06174 162 ALLAAILLLLVVPDPPesarakneEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSfstlLPLFLLDLGGLSVAVA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 242 SIIMGLTIFGGMVFQYPFGRLSDLISRRYVIAFLALMSSVLCVAIIEIGkDNVYIISILSFLLGGTTFCLYPIGISHTCD 321
Cdd:cd06174 242 GLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLA-PSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 890045417 322 RINNNQIVSASQTLLLSYGLGATFGPIIAPLFNIVMVDGEILVFIMVMSLPLCLFMLW 379
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
38-378 |
2.66e-11 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 64.55 E-value: 2.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 38 KLDSLNTSEFLIGGLTTAYYAGMVLGAFKLEGLILRVGHIRAYSAFASMLAVFSILHGFYVDVYFWLLLRFLGGIATAGL 117
Cdd:cd17316 27 AEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 118 YIVIESWILSATDNKNRGGSLAL----YMIALYVAQAGGQWLLNIGDQDTL--ILYCIAAVFASLSVIplaltrttapif 191
Cdd:cd17316 107 YPGASTYVAEFAPSKRRGFALGLlqsgWALGALLAALVASLLIPLLSGDWGwrILFLIGALPALLALL------------ 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 192 sepetlsigqMIKLSPSGVSTCFVSGMILGSIYGLYP-IFIQNSGYPTAEISIIMGLTIFGGMVFQYPFGRLSDLISRRY 270
Cdd:cd17316 175 ----------LRRRTLLLILLWFFISFGYYGLTTFLPtYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKK 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 271 VIAFLALMSSVLCVAIIEIGKDNVYIISILSFLLGGTTFCLYPIGISHTCDRINNNQIVSASQtllLSYGLGATFGPIIA 350
Cdd:cd17316 245 TLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVG---LSYNLGRLGGGGAP 321
|
330 340
....*....|....*....|....*...
gi 890045417 351 PLFNIVMVDGEILVFIMVMSLPLCLFML 378
Cdd:cd17316 322 PLIALLLASTGGTGVPALILALLAIVAL 349
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
40-380 |
2.75e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 64.51 E-value: 2.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 40 DSLNTSEFLIGGLTTAYYAGMVLGAFKLEGLILRVGHIRAYSAFASMLAVFSILHGFYVDVYFWLLLRFLGGIATAGLYI 119
Cdd:COG2271 38 ADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 120 VIESWILSATDNKNRGGSLALYMIALYVAQA-----GGQWLLNIGDQDTLILYCIAAVFASLsviplaltrttapifsep 194
Cdd:COG2271 118 AALKLIAEWFPPKERGRALGIFNAGGPLGGAlapplLGWLLAAFGWRAAFLILGLPGLLLAL------------------ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 195 etlsigqmIKLSPSGVSTCFVSGMILGSIYGLYPIFIQNSGYPTAEISIIMGLTIFGGMVFQYPFGRLSDLISRRYVIAF 274
Cdd:COG2271 180 --------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 275 LALMSSVLCVAIIEIGKDNVYIISILSFLLGGTTFCLYPIGISHTCDRINNNQIVSASQTLLLSYGLGATFGPIIAPL-- 352
Cdd:COG2271 252 AIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYll 331
|
330 340 350
....*....|....*....|....*....|..
gi 890045417 353 ----FNIVMVdgeILVFIMVMSLPLCLFMLWR 380
Cdd:COG2271 332 datgYQAAFL---LLAALALLAALLALLLLRE 360
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
21-350 |
1.12e-08 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 56.81 E-value: 1.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 21 LIILTLGSAL--LTTFLSLKLDSLNTSEFLIGGLTTAYYAGMVLGAFKLEGLILRVGHIRAYSAFASMLAVFSILHGFYV 98
Cdd:COG2807 25 LVALNLRPAItsVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 99 DVYFWLLLRFLGGIATAGLYIVIESWILSATDNKnRGGSLALYMIALYVAQAGGQWLL-----NIGDQDTLILYCIAAVF 173
Cdd:COG2807 105 SVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTvplaaALGWRGALAVWALLALL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 174 ASLSVIPLALTRTTAPIFSePETLSIGQMIKlSPSGVSTCFVSGMILGSIYGLY---PIFIQNSGYPTAEISIIMGLTIF 250
Cdd:COG2807 184 ALLLWLPLLRRRPAAAAAA-PAAASLRSLWR-SPLAWLLTLFFGLQSLLYYAVVawlPPILRDAGLSAATAGLLLSLFQL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 251 GGMVFQYPFGRLSDLISRRYVIAFLALMSSVLCVAIIEIGKDNVYIISILsfLLGGTTFCLYPIGISHTCDRINNNQIVS 330
Cdd:COG2807 262 AGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAV--LLGLGQGGLFPLALTLIGLRARTPAEAA 339
|
330 340
....*....|....*....|.
gi 890045417 331 ASQTLLLSYG-LGATFGPIIA 350
Cdd:COG2807 340 ALSGMAQSVGyLLAALGPLLV 360
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
18-155 |
5.81e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 54.16 E-value: 5.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 18 LLSLIILTLGSALLTTFLSLKLDSLNTSEFLIGGLTTAYYAGMVLGAFKLEGLILRVGHIRAYSAFASMLAVFSILHGFY 97
Cdd:cd06173 215 LALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLS 294
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 890045417 98 VDVYFWLLLRFLGGIATAGLYIVIESWILSATDNKNRGGSLALYMIALYVAQAGGQWL 155
Cdd:cd06173 295 PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALL 352
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
40-317 |
4.33e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 51.40 E-value: 4.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 40 DSLNTSEFLIGGLTTAYYAGMVLGAFKLEGLILRVGHIRAYSAFASMLAVFSILHGFYVDVYFWLLLRFLGGIATAGLYI 119
Cdd:cd17324 27 RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 120 VIESWILSATDNKNRGGSLALYMIALYVAQAGGQ----WLLNIGDQDTLILycIAAVFASLSVIPLALTRTTAPIFSEPE 195
Cdd:cd17324 107 IAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRplggLLGQLLGWRAAFL--AIAVLALLAALLLWRLLPSLPPKKPGS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 196 TLSIGQMIKL--SPSGVSTCFVSGMILGSIYGLY----PIFIQNSGYPTAEISIIMGLTIFGGMVFQYPFGRLSDLISRR 269
Cdd:cd17324 185 LGLLSSLLLLlrNPRLRLAYLITFLLFGGFFALYtylaPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRR 264
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 890045417 270 YVIAFLALMssVLCVAIIEIGKDNVYIISILSFLLGGTTFCLYPIGIS 317
Cdd:cd17324 265 ALLIALLLL--AAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQT 310
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
40-350 |
5.83e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 51.42 E-value: 5.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 40 DSLNTSEFLIGGLTTAYYAGMVLGAFKLEGLILRVGHIRAYSAFASMLAVFSILHGFYVDVYFWLLLRFLGGIATAGLYI 119
Cdd:COG2223 33 EEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 120 VIESWILSATDNKNRGGSLALYMIALYVAQAGGQWLLN-----IGDQDTLILYCIAAVFASlsVIPLALTRTTAPIFSEP 194
Cdd:COG2223 113 VGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPlliaaFGWRNAFLILGILLLVVA--VLAWLFLRDPPAGAAAA 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 195 ETLSIGQMIKL--SPSGVSTCFVSGMILGSIYG----LYPIFIQNSGYPTAEISIIMGLTIFGGMVFQYPFGRLSDLISR 268
Cdd:COG2223 191 AKASLRDQLEAlrDPRFWLLSLLYFGTFGSFIGfsswLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGG 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 269 RYVIAFLALMSSVLCVAIIeIGKDNVYIISILSFLLGGTTFCLYPIGISHTCDRINNNQIVSASQTLLLSYGLGATFGPI 348
Cdd:COG2223 271 RRVLLIVFALMALGLLLLA-LALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPL 349
|
..
gi 890045417 349 IA 350
Cdd:COG2223 350 LF 351
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
18-350 |
1.06e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 50.29 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 18 LLSLIILTLGSALLTTFLSLKLDSLNTSEFLIGGLTTAYYAGMVLGAFKLEGLILRVGHIRAYSAFASMLAVFSILHGFY 97
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 98 VDVYFWLLLRFLGGIATAGLYIVIESWILSATDNKNRGGSLALYMIALYVAQAGGQWL-LNIGDQDTL-ILYCIAAVFAS 175
Cdd:cd17489 82 TSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALgLFLYQHLGFaVLFIVAAVLAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 176 LSVIPLALTRTTAPIFSEPETLSIGQMIK------LSPSGVstCFVSGMILGSIYGLYPIFIQNSGYptAEISIIMGLTI 249
Cdd:cd17489 162 LALLLVFLVKDPPPVAAEEAEAGTRAFRRlvekkvLPPALI--LFLASIAYGAISTFLPLYAAERGI--SNAGLFFTVYA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 250 FGGMVFQYPFGRLSDLISRRYVIAFLALmssVLCVAIIEIGKDNVYIISILSFLLGGTTF-CLYPIGISHTCDRINNNQI 328
Cdd:cd17489 238 IALLLSRPFSGKLSDRKGPKTVIIPGLL---LLALGLLLLSFAGSPWMLLLAAVLYGLGFgLLFPALQALAVDLVPPHRR 314
|
330 340
....*....|....*....|..
gi 890045417 329 VSASQTLLLSYGLGATFGPIIA 350
Cdd:cd17489 315 GAANGTFFIFFDLGIGLGGLLL 336
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
9-349 |
1.74e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 49.85 E-value: 1.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 9 KNYKHLITPLLSLIILT-LGSALLTTFLSLKLDSLNTSEFLIGGLTTAYYAGMVLGAFKLEGLILRVGHIRAYSAFASML 87
Cdd:COG0738 4 KNYRRALIAIYLLFFLWgFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 88 AVFSILHGFYVDVYFWLLLRFLGGIATAGLYIVIESWILSATDNKNR---GGSLALYMIALYVAQAGGQWLLNIG-DQDT 163
Cdd:COG0738 84 ALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAAsrlNLLHAFFSLGALLGPLLGGLLILLGlSLSW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 164 LILYCIAAVFASLSVIPLALTR----TTAPIFSEPETLSIGQMIKLSP--SGVSTCFVSGMILGSIYGLYPIFIQNS-GY 236
Cdd:COG0738 164 HLPYLILAVLLLLLALLFLRSKlpeiEEEEEEAAGSAASLKSLLKNPRllLGGLAIFLYVGAEGAIGDWLPLYLKDVlGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 237 PTAEISIIMGLTIFGGMVFQYPFGRLSDLISRRYVIAFLALMSSVLCVAIIEIGKDNVYIISIlsFLLGGTTFCLYPIGI 316
Cdd:COG0738 244 SEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGL--ALVGLGLSLMFPTIF 321
|
330 340 350
....*....|....*....|....*....|...
gi 890045417 317 SHTCDRINNNQIVSASQTLLLSYgLGATFGPII 349
Cdd:COG0738 322 SLALDGLGKRTAAAVSAVLIMGI-VGGAIGPPL 353
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
26-350 |
8.43e-06 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 47.58 E-value: 8.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 26 LGSALLTTFLSLKLDSLNTSEFLIGGLTTAYYAGMVLGAFKLEGLILRVGHIRAYSAFASMLAVFSILHGFYVDVYFWLL 105
Cdd:cd17335 11 AALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFVAQIFWLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 106 L--RFLGGIATAGLYIVIESWILSATDNKNR-------GGSLALYMIALYVAQAGGQWLLNIGDQDTLILYCIAAVFASL 176
Cdd:cd17335 91 LllVILGAFFSAPVVPLVDSITLQYLGEERErygkqrlWGSIGFGIAALLVGILIDRSSTYKNYTIAFYVFAVLMLLALL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 177 SVIPLALTRTTAPifSEPETLSIGQMIKLSPSGV--STCFVSGMILGSIYGLYPIFIQNSGYPTAEISIIMGLTIFGGMV 254
Cdd:cd17335 171 LALKFPFRPKHPE--PNENTGGLLALLRNPRVLAflLVAFLMGFGHGLIYSFLFWHLQDLGGSKTLIGLLWTVGVVSEIP 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 255 FQYPFGRLSDLISRRYVIaFLALMSSVLCVAIIEIGKDNVYIISILsfLLGGTTFCLYPIGISHTCDRINNNQIVSASQT 334
Cdd:cd17335 249 FFFFSSRLIQRFGHVGLL-YLGLLAYVVRWLLYSFLENPWLVLPIE--LLHGLTFALVWAAAVSYASAAAPPGLRATAQG 325
|
330
....*....|....*...
gi 890045417 335 LL--LSYGLGATFGPIIA 350
Cdd:cd17335 326 LLqgLYFGLGGGLGSLIG 343
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
214-378 |
1.78e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 46.26 E-value: 1.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 214 FVSGMILGSIYGLYPIFIQNS-GYPTAEISIIMGLTIFGGMVFQYPFGRLSDLISRRYVIAFLALMSSVLCVAIIEIGkd 292
Cdd:pfam07690 6 FLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS-- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 293 NVYIISILSFLLGGTTFCLYPIGISHTCDRINNNQIVSASQTLLLSYGLGATFGPIIAPLFNIVMVDGEILVFIMVMSLP 372
Cdd:pfam07690 84 SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLL 163
|
....*.
gi 890045417 373 LCLFML 378
Cdd:pfam07690 164 AAVLLL 169
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
139-305 |
7.74e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.51 E-value: 7.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 139 ALYMIALYVAQAGGQWLLNIGDQDT----LILYCIAAVFASLSVIPLALTrTTAPIFSEPETLSIGQMIKLSPSG----- 209
Cdd:COG2211 154 AFAGLGGLLASVLPPPLVAAFGGDAalgyRLTALIFAVLGLLAFLLTFFG-TKERPVPEEEKVSLKESLKALLKNrpfll 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 210 -VSTCFVSGMILGSIYGLYPIFIQNS-GYPTAEISIIMGLTIFGGMVFQYPFGRLSDLISRRYVIAFLALMSSVLCVAII 287
Cdd:COG2211 233 lLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLF 312
|
170
....*....|....*...
gi 890045417 288 EIGKDNVYIISILSFLLG 305
Cdd:COG2211 313 FLGPGNLWLLLVLAALAG 330
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
212-379 |
2.12e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.04 E-value: 2.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 212 TCFVSGMILGSIYGLYPIFIQNSGYPTAEISIIMGLTIFGGMVFQYPFGRLSDLISRRYVIAFLALMSSVLCVAIIEIgk 291
Cdd:COG2814 18 GAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA-- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 292 DNVYIISILSFLLGGTTFCLYPIGISHTCDRINNNQIVSASQTlllsYGLGATFGPIIAPLFNIVMVDGEILVFIMVMSL 371
Cdd:COG2814 96 PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGL----LGAGLGLGPALGPLLGGLLADLFGWRWVFLVNA 171
|
....*...
gi 890045417 372 PLCLFMLW 379
Cdd:COG2814 172 VLALLALL 179
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
14-287 |
7.24e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 41.34 E-value: 7.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 14 LITPLLSLIILTLGSALLTTFLSLKLDSLNTSEFLIGGLTTAYYAGMVLGAFKLEGLILRVGHIRAYSAFASMLAVFSIL 93
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 94 HGFYVDVYFWLLLRFLGGIATAGLYIVIESWILSATDNKNRGGSLALYMIALYVAQAGGQwLLNIGDQDTL---ILYCIA 170
Cdd:COG0477 96 CGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGP-LLGGLLVAALgwrWIFLIN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 171 AVFASLSVIPLALTRTTAPIFSEPETLSIGQMIKLSPSGVSTCFVSGMILGSIYGLYPIFIQNSGYPTAEISIIMGLTIF 250
Cdd:COG0477 175 APLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLL 254
|
250 260 270
....*....|....*....|....*....|....*..
gi 890045417 251 GGMVFQYPFGRLSDLISRRYVIAFLALMSSVLCVAII 287
Cdd:COG0477 255 ALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLL 291
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
30-306 |
1.01e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 41.13 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 30 LLTTFLSLKLDSLNTSEFLIGGLTTAYYAGMVLGAFKLEGLILRVGHIRAYSAFASMLAVFSILHGFYVDVYFWLLLRFL 109
Cdd:cd17371 17 LLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 110 GGIATAGLYIVIESWILSATDNKNRGGSLALYMIALYV--AQAGGQWLLNIGDQDTLILYCIAAVFASLSVIPLALTR-- 185
Cdd:cd17371 97 AGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVgwLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRrf 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 186 -TTAPIFSEPETlsIGQMIKLSPSGVS---------TCFVSGMILGSIYGLYPIFIQNSGYPTAE-------ISIIMGLT 248
Cdd:cd17371 177 vKEPPQWQAARA--ARRHFADRPSLRElfsppllrtTLLASLLATGALGGYYGITTWLPSYLTGErglsfegSAGYLVVT 254
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 890045417 249 IFGGMVFQYPFGRLSDLISRRYVIAFLALMSSVLCVAIIEIGKDN---VYIISILSFLLGG 306
Cdd:cd17371 255 ILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPtliLILGFPLGFFASG 315
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
50-150 |
3.28e-03 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 39.96 E-value: 3.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 50 GGLTTAYYAGMVLGAFKLEGLILRVGHIRAYSAFASMLAVFSILHGFYVDVYFWLLLRFLGGIATAGLYIVIESWILSAT 129
Cdd:TIGR01299 205 GMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFL 284
|
90 100
....*....|....*....|....*
gi 890045417 130 DNKNRGGSLA----LYMIALYVAQA 150
Cdd:TIGR01299 285 AQEKRGEHLSwlcmFWMIGGIYAAA 309
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
102-285 |
4.36e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.18 E-value: 4.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 102 FWLLLRFLGGIATAGLYIVIESWILSATDNKNRGGSLALYMIALYVAQA----GGQWLLN-IGDQDTLILYCIAAVFASL 176
Cdd:cd17355 94 LYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLvflpLGAALIEaFGWRTALLVLALLALLVLV 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 177 SVIPLALTRT------TAPIFSEPETLSIGQMIKLSPSG---VSTCFVSGMILGSIYGLYPIFIQNSGYPTAEISIIMGL 247
Cdd:cd17355 174 PVLLLLRRRPadlalrAYDDASPASPGSTLKEALRSASFwllALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALAL 253
|
170 180 190
....*....|....*....|....*....|....*...
gi 890045417 248 TIFGGMVFQYPFGRLSDLISRRYVIAFLALMSSVLCVA 285
Cdd:cd17355 254 IGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLAL 291
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
50-350 |
5.62e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 38.82 E-value: 5.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 50 GGLTTAYYAGMVLGAFKLEGLILRVGHIRAYSAFASMLAVFSILHGFYVDVYFWLLLRFLGGIATAGLYIVIESWILSAT 129
Cdd:cd06180 37 GWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 130 DNKNRGGSLALY-------MIALYVAQAGGQWLLNIGDQDTLILYCIAAVFASLSviplaltrttAPIFSEPETLSIGQM 202
Cdd:cd06180 117 TAAGRGHLIGLLfagvglgIALSGLLVPAGLGGGLSWRAGWLALALLSAVLLLLS----------FLLLRRGPSAPTEAS 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 203 IKLSPSGVStcfVSGMILGSIYGLY-----------PIFIQNSGYPTAEISIIMglTIFGGMVFQYPF--GRLSDLISRR 269
Cdd:cd06180 187 AAESAPGLN---RPLWRLALAYGLFgfgyiitatflPLIARETGAGSLLAGLLW--SLFGLAAVPSCFlwGALSDRWGTR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 270 YVIAfLALMSSVLCVAiIEIGKDNVYIISILSFLLGGTTFclypiGISHTCDRINNNQIVSASQTLL----LSYGLGATF 345
Cdd:cd06180 262 RALA-ANLLVQAVGVL-LPLLSPGPAGLVLSAVLFGGTFM-----AITALVMALARELAPPAAPRALalmtASFGVGQIL 334
|
....*
gi 890045417 346 GPIIA 350
Cdd:cd06180 335 GPLLA 339
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
41-380 |
5.74e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 38.71 E-value: 5.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 41 SLNTSEFLIGGLTTAYYAGMVLGAFKLEGLILRVGHIRAYSAFASMLAVFSILHGFYVDVYFWLLLRFLGGIATAGLYIV 120
Cdd:cd17320 28 DLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVV 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 121 IESWILSATDNKNRGGSLALYMIALYVAQA-----GGQWLLNIGDQD---TLILYCIAAVFASLSVIPLALTRTTAPIFS 192
Cdd:cd17320 108 ARAIVRDLYSGAELAKIFSLLMMILAIAPAlapllGGLLLLFFGWRAifvFLALLGLLLLLLVLLFLPETLPEEKRKPLL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 193 EPETLSIGQMIKlSPSGVSTCFVSGMILGSIYGLYP----IFIQNSGYPTAEISIIMGLTIFGGMVFQYPFGRLSDLISR 268
Cdd:cd17320 188 SSLLRAYKRVLK-NRRFLGYALALGLSFAGLFAYLAaapfIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGP 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 269 R---YVIAFLALMSSVLCVAIIEIGKDNVYIISILSFLLGGTTFCLYPIGISHTCDRINNNQIVSASQTLLLSYGLGATF 345
Cdd:cd17320 267 RrllRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALA 346
|
330 340 350
....*....|....*....|....*....|....*
gi 890045417 346 GPIIAPLFNIVMVDgeILVFIMVMSLPLCLFMLWR 380
Cdd:cd17320 347 GALVGLLPNGTALP--MGLLILVLGLLALLLLILL 379
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
56-189 |
8.93e-03 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 38.12 E-value: 8.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 56 YYAGMVLGAFKLEGLILRVGHIRAYSAFASMLAVFSIlhGFYVDVYFWLLLRFLGGIATAGLYIVIESWIL--SATDNKN 133
Cdd:pfam06779 41 YLAGALLASFAWRHGASRLRPALLAGLLATVLLLLAM--AATSSFWAVLLIRFLAGVASAAVMIFGSSLILghATAARRA 118
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 890045417 134 RGGSLALYMIALYVAQAG-GQWLLNIGDQDTLILYCIAAVFASLSVIPLALTRTTAP 189
Cdd:pfam06779 119 FVGALLFAGVGIGIALSGlLVPLGLQLGLGGSSLWYGAGVLSAVLTLAVFPLLPRRA 175
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
49-286 |
9.27e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 38.11 E-value: 9.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 49 IGGLTTAYYAGMVLGAFKLEGLILRVGHIRAYSAFASMLAVFSILHGFYVDVYFWLLLRFLGGIATAGLYIVIESWILSA 128
Cdd:TIGR00895 54 LGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEY 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 129 TDNKNRGGSLALYMI-------------ALYVAQAGGQWLLNIGDQDTLILYCIAAVFASLSVIPLALTRTTAPIFSEPE 195
Cdd:TIGR00895 134 APKRFRGTAVGLMFCgypigaavggflaGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNA 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890045417 196 TLSIGQMIKLSPSGVSTCFVSG-------------------------MILGSIYGL---YPIFIQNSGYPTAEISIIMGL 247
Cdd:TIGR00895 214 IAPQMQAEAQSALPEQKSTQGTkrsvfkalfqgktaritvllwllyfMLLVGVYFLtnwLPKLMVELGFSLSLAATGGAL 293
|
250 260 270
....*....|....*....|....*....|....*....
gi 890045417 248 TIFGGMVFQYPFGRLSDLISRRyVIAFLALMSSVLCVAI 286
Cdd:TIGR00895 294 FNFGGVIGSIIFGWLADRLGPR-VTALLLLLGAVFAVLV 331
|
|
| |
