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MULTISPECIES: 2-oxoglutarate dehydrogenase E1 component [Bacillus]
Protein Classification
2-oxoglutarate dehydrogenase component E1 family protein ( domain architecture ID 1562477 )
2-oxoglutarate dehydrogenase component E1 family protein may catalyzes the decarboxylation of 2-oxoglutarate and the formation of TPP-hydroxysuccinate or the conversion of 2-oxoadipate (alpha-ketoadipate) to glutaryl-CoA and CO(2).
List of domain hits
Name
Accession
Description
Interval
E-value
kgd super family
cl39092 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
17-940
0e+00
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
TIGR00239 :Pssm-ID: 476867 [Multi-domain]
Cd Length: 929
Bit Score: 1488.59
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 17 G P N LG Y AL ELY DQ Y TQ DP N S I D PDLKEM FD E L GA P P ----------- S DIKEASGTKEK G R VT ADLIQKIA S A V RLAED I 85
Cdd:TIGR00239 4 G A N QS Y IE ELY ED Y LT DP D S V D ASWRST FD Q L PG P G papdqfhsptr S YFRRLAKDASR G S VT ISDPDTNV S Q V KVLQL I 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 86 R T Y --- GHL N A SVN PL R - K DEK K SELFP LS D YGLTE EEIK --- A I PAS V IC KDA PKNI SN g LE AI Q Y L RN TY KRT I SF E F 158
Cdd:TIGR00239 84 R A Y rfr GHL H A NLD PL G l K QQD K VPELD LS F YGLTE ADLQ etf N I GSF V SG KDA TMKL SN - LE LL Q A L KQ TY CGS I GA E Y 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 159 D H VHDFK E RE WL TRK IESGE LF Q K NS A EK LS a V L E RLT EV EGFE Q FL HRT F V G Q KRFS I EGLDALVP V L DD II AQ SV K SG 238
Cdd:TIGR00239 163 M H ITSTE E KR WL QQR IESGE RA Q F NS E EK KR - F L S RLT AA EGFE R FL GAK F P G A KRFS L EGLDALVP M L KE II RH SV N SG 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 239 T TS V NI GMAHRGRLNVL AH VLGKP Y E I IFSEF QHAPNKD L VPS egsigisygw TGDVKYH L G ANRELQDAET K SARIT LA 318
Cdd:TIGR00239 242 T RD V VL GMAHRGRLNVL VN VLGKP P E D IFSEF AGKHKSH L PDG ---------- TGDVKYH M G RFSSDFTTDG K LVHLA LA 311
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 319 N NPSHLE FIN P I V E GSTRA AQETRTQ S gypv QDE TK S LAILIHGDAAF P G E G I V A ETLN L S S L K GY Q VGG A IHII A NN M I 398
Cdd:TIGR00239 312 F NPSHLE IVS P V V I GSTRA RLDRLND S ---- PES TK V LAILIHGDAAF A G Q G V V Q ETLN M S K L R GY S VGG T IHII I NN Q I 387
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 399 GFTT ESAES RST K Y A SDLAK GYEI PI V HVNADDPEA CLS A VKF AVEYR K TF NK D FL IDL I GYRR Y GHNE M DEPS T TQP ML 478
Cdd:TIGR00239 388 GFTT NPLDA RST P Y C SDLAK MIQA PI F HVNADDPEA VAF A TRL AVEYR N TF KR D VF IDL V GYRR H GHNE A DEPS A TQP LM 467
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 479 Y DAVR KHPT VKQIF A E KLV K EGV L TEE V V QNIEKSVTKRI E D A YQK VPS KK E - H TA CEI --- EL PEPVSNGF P DVDTSID 554
Cdd:TIGR00239 468 Y QKIK KHPT PRKVY A D KLV S EGV A TEE D V TEMVNLYRDAL E A A DCV VPS WR E m N TA SFT wsp EL NHEWDEEY P NKVEMKR 547
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 555 FDV L R K LNG E lin W PE SFNVFGKLKR I LER R A KA - FDDDRKVE W SL AE S LAFA SILK DG T P I RL T G Q DSERGTF A QR NL V 633
Cdd:TIGR00239 548 LQE L A K RIS E --- V PE GVEMHSRVAK I YFD R T KA m AAGEKLFD W GG AE N LAFA TLVD DG I P V RL S G E DSERGTF F QR HA V 624
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 634 LHD SET G KEFV PL H HL SDCSTS F A V H NS P LSE G SVLGFEYGY NVH SP E TLV L WEAQ Y GDFAN A AQV YF DQFIS A G RA KWG 713
Cdd:TIGR00239 625 LHD QSN G STYT PL Q HL HNGQGA F R V W NS V LSE E SVLGFEYGY ATT SP R TLV I WEAQ F GDFAN G AQV VI DQFIS S G EQ KWG 704
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 714 Q K SGLVMLLPHGYEGQGPEHSSGR I ERFLQLAAE N N WT V ANL T SA AQ Y FHILRRQA kml LR EEI RPLV I M T PKSLLR N P N 793
Cdd:TIGR00239 705 Q M SGLVMLLPHGYEGQGPEHSSGR L ERFLQLAAE Q N MQ V CVP T TP AQ V FHILRRQA --- LR GMR RPLV V M S PKSLLR H P L 781
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 794 T VS EVQ EL S E SR FQPV Y --- E Q SGLS H D Y E K V T RLVL S SGKV SI D I sd H FNKLED G KEWLH I A RIEQLYPFP A K G VKE LF 870
Cdd:TIGR00239 782 A VS SLE EL A E GT FQPV I gei E E SGLS L D P E G V K RLVL C SGKV YY D L -- H EQRRKN G QKDVA I V RIEQLYPFP H K A VKE VL 859
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 871 AKL PNLKEIVW V QEEP Q NMGAW G Y IS P Y L T E IA PEGVSV Q Y I GR RRRS SPA E G DPTV H K K E Q ERIVS D S L 940
Cdd:TIGR00239 860 QQY PNLKEIVW C QEEP L NMGAW Y Y SQ P H L R E VI PEGVSV R Y A GR PASA SPA V G YMSL H Q K Q Q QDLLN D A L 929
Name
Accession
Description
Interval
E-value
2oxo_dh_E1
TIGR00239 2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists ...
17-940
0e+00
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists of this thiamine pyrophosphate-binding subunit (E1), dihydrolipoamide succinyltransferase (E2), and lipoamide dehydrogenase (E3). The E1 ortholog from Corynebacterium glutamicum is unusual in having an N-terminal extension that resembles the dihydrolipoamide succinyltransferase (E2) component of 2-oxoglutarate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 161785 [Multi-domain]
Cd Length: 929
Bit Score: 1488.59
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 17 G P N LG Y AL ELY DQ Y TQ DP N S I D PDLKEM FD E L GA P P ----------- S DIKEASGTKEK G R VT ADLIQKIA S A V RLAED I 85
Cdd:TIGR00239 4 G A N QS Y IE ELY ED Y LT DP D S V D ASWRST FD Q L PG P G papdqfhsptr S YFRRLAKDASR G S VT ISDPDTNV S Q V KVLQL I 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 86 R T Y --- GHL N A SVN PL R - K DEK K SELFP LS D YGLTE EEIK --- A I PAS V IC KDA PKNI SN g LE AI Q Y L RN TY KRT I SF E F 158
Cdd:TIGR00239 84 R A Y rfr GHL H A NLD PL G l K QQD K VPELD LS F YGLTE ADLQ etf N I GSF V SG KDA TMKL SN - LE LL Q A L KQ TY CGS I GA E Y 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 159 D H VHDFK E RE WL TRK IESGE LF Q K NS A EK LS a V L E RLT EV EGFE Q FL HRT F V G Q KRFS I EGLDALVP V L DD II AQ SV K SG 238
Cdd:TIGR00239 163 M H ITSTE E KR WL QQR IESGE RA Q F NS E EK KR - F L S RLT AA EGFE R FL GAK F P G A KRFS L EGLDALVP M L KE II RH SV N SG 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 239 T TS V NI GMAHRGRLNVL AH VLGKP Y E I IFSEF QHAPNKD L VPS egsigisygw TGDVKYH L G ANRELQDAET K SARIT LA 318
Cdd:TIGR00239 242 T RD V VL GMAHRGRLNVL VN VLGKP P E D IFSEF AGKHKSH L PDG ---------- TGDVKYH M G RFSSDFTTDG K LVHLA LA 311
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 319 N NPSHLE FIN P I V E GSTRA AQETRTQ S gypv QDE TK S LAILIHGDAAF P G E G I V A ETLN L S S L K GY Q VGG A IHII A NN M I 398
Cdd:TIGR00239 312 F NPSHLE IVS P V V I GSTRA RLDRLND S ---- PES TK V LAILIHGDAAF A G Q G V V Q ETLN M S K L R GY S VGG T IHII I NN Q I 387
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 399 GFTT ESAES RST K Y A SDLAK GYEI PI V HVNADDPEA CLS A VKF AVEYR K TF NK D FL IDL I GYRR Y GHNE M DEPS T TQP ML 478
Cdd:TIGR00239 388 GFTT NPLDA RST P Y C SDLAK MIQA PI F HVNADDPEA VAF A TRL AVEYR N TF KR D VF IDL V GYRR H GHNE A DEPS A TQP LM 467
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 479 Y DAVR KHPT VKQIF A E KLV K EGV L TEE V V QNIEKSVTKRI E D A YQK VPS KK E - H TA CEI --- EL PEPVSNGF P DVDTSID 554
Cdd:TIGR00239 468 Y QKIK KHPT PRKVY A D KLV S EGV A TEE D V TEMVNLYRDAL E A A DCV VPS WR E m N TA SFT wsp EL NHEWDEEY P NKVEMKR 547
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 555 FDV L R K LNG E lin W PE SFNVFGKLKR I LER R A KA - FDDDRKVE W SL AE S LAFA SILK DG T P I RL T G Q DSERGTF A QR NL V 633
Cdd:TIGR00239 548 LQE L A K RIS E --- V PE GVEMHSRVAK I YFD R T KA m AAGEKLFD W GG AE N LAFA TLVD DG I P V RL S G E DSERGTF F QR HA V 624
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 634 LHD SET G KEFV PL H HL SDCSTS F A V H NS P LSE G SVLGFEYGY NVH SP E TLV L WEAQ Y GDFAN A AQV YF DQFIS A G RA KWG 713
Cdd:TIGR00239 625 LHD QSN G STYT PL Q HL HNGQGA F R V W NS V LSE E SVLGFEYGY ATT SP R TLV I WEAQ F GDFAN G AQV VI DQFIS S G EQ KWG 704
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 714 Q K SGLVMLLPHGYEGQGPEHSSGR I ERFLQLAAE N N WT V ANL T SA AQ Y FHILRRQA kml LR EEI RPLV I M T PKSLLR N P N 793
Cdd:TIGR00239 705 Q M SGLVMLLPHGYEGQGPEHSSGR L ERFLQLAAE Q N MQ V CVP T TP AQ V FHILRRQA --- LR GMR RPLV V M S PKSLLR H P L 781
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 794 T VS EVQ EL S E SR FQPV Y --- E Q SGLS H D Y E K V T RLVL S SGKV SI D I sd H FNKLED G KEWLH I A RIEQLYPFP A K G VKE LF 870
Cdd:TIGR00239 782 A VS SLE EL A E GT FQPV I gei E E SGLS L D P E G V K RLVL C SGKV YY D L -- H EQRRKN G QKDVA I V RIEQLYPFP H K A VKE VL 859
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 871 AKL PNLKEIVW V QEEP Q NMGAW G Y IS P Y L T E IA PEGVSV Q Y I GR RRRS SPA E G DPTV H K K E Q ERIVS D S L 940
Cdd:TIGR00239 860 QQY PNLKEIVW C QEEP L NMGAW Y Y SQ P H L R E VI PEGVSV R Y A GR PASA SPA V G YMSL H Q K Q Q QDLLN D A L 929
sucA
PRK09404 2-oxoglutarate dehydrogenase E1 component; Reviewed
3-941
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1433.75
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 3 QNS MK QRMNWEDFY G P N LG Y AL ELY D QY TQ DP N S I D PDLKEM FD E L GAPPS D IKEASGTKE ------ KG RV TADLIQKIA 76
Cdd:PRK09404 2 NSA MK AWLDSSFLF G A N AA Y IE ELY E QY LK DP D S V D EEWRAF FD G L PGVAP D VAHSAVRES frrlak PA RV SSAVSDPQV 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 77 SAVR L AEDI R TY GHL N A SVN PL RKDEKKS - ELFPLSD YGLTE EEIKAIPASVICKDAPKN i SNGL E A I QY L RN TY KRT I S 155
Cdd:PRK09404 82 KVLQ L INAY R FR GHL A A NLD PL GLWKRPD v PELDPAF YGLTE ADLDRTFNTGSLALGKET - ATLR E I I EA L KK TY CGS I G 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 156 F E FD H VH D FK ER E WL TRK IESG EL fq KN SAE KLS A V LERLT EV EGFE Q FLH RT FVGQKRFS I EG LDA L V P V LD D II AQSV 235
Cdd:PRK09404 161 V E YM H IS D PE ER R WL QQR IESG RP -- SF SAE EKK A I LERLT AA EGFE R FLH TK FVGQKRFS L EG GES L I P M LD E II RRAG 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 236 K S G TTSVN IGMAHRGRLNVL AH VLGKP YEII F S EF QHAPNK D lvpsegsigi SYGWT GDVKYHLG ANRELQD a ETKSARI 315
Cdd:PRK09404 239 K L G VKEIV IGMAHRGRLNVL VN VLGKP PRDL F A EF EGKHGP D ---------- EVLGS GDVKYHLG FSSDRET - DGGEVHL 307
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 316 T LA N NPSHLE FI NP I VEGS T RA A Q ET R tqsg YPV QD ET K S L A ILIHGDAAF P G E G I VAETLNLS S L K GY QV GG A IHI IA N 395
Cdd:PRK09404 308 S LA F NPSHLE IV NP V VEGS V RA R Q DR R ---- GDG QD RK K V L P ILIHGDAAF A G Q G V VAETLNLS Q L R GY RT GG T IHI VI N 383
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 396 N M IGFTT ESAES RST K Y AS D L AK GYEI PI V HVN A DDPEA CLS A VKF A V EYR KT F N KD FL IDL IG YRR Y GHNE M DEPS T TQ 475
Cdd:PRK09404 384 N Q IGFTT SPPDD RST P Y CT D V AK MVQA PI F HVN G DDPEA VVF A TRL A L EYR QK F K KD VV IDL VC YRR H GHNE G DEPS F TQ 463
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 476 P ML Y DAVR KHPT VKQIF A E KLV K EGV L TEE VVQNIEKSVTKRIEDAYQK V PSKKEHTACEIE - L P EPVSNGFPD VDT SID 554
Cdd:PRK09404 464 P LM Y KKIK KHPT TRELY A D KLV A EGV I TEE EADEMVNEYRDALDAGFEV V KEWRPADWLAGD w S P YLGHEWDDP VDT GVP 543
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 555 FDV L RK L NGE L INW PE S F N V FG K L K R ILE R R AKAFDDDRKVE W SL AE S LAFAS I L KD G T P I RL T GQDS E RGTF AQ R NL VL 634
Cdd:PRK09404 544 LER L KE L AEK L TTV PE G F K V HP K V K K ILE D R REMAEGEKPID W GM AE A LAFAS L L DE G Y P V RL S GQDS G RGTF SH R HA VL 623
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 635 HD SE TG KEFV PL H HLS DCST SF A V HN SPLSE GS VLGFEYGY NVHS P E TLV L WEAQ Y GDFAN A AQV YF DQFIS A G RA KWG Q 714
Cdd:PRK09404 624 HD QK TG ETYI PL N HLS EGQA SF E V YD SPLSE EA VLGFEYGY STAE P N TLV I WEAQ F GDFAN G AQV VI DQFIS S G EQ KWG R 703
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 715 K SGLVMLLPHGYEGQGPEHSS G R I ERFLQL A AE N N WT V A N L T SA AQYFH I LRRQA K mll R EEIR PLV I MTPKSLLR N P NT 794
Cdd:PRK09404 704 L SGLVMLLPHGYEGQGPEHSS A R L ERFLQL C AE D N MQ V C N P T TP AQYFH L LRRQA L --- R PFRK PLV V MTPKSLLR H P LA 780
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 795 VS EVQ EL S E SR FQPV YEQSG l SH D YE KV T R L VL S SGKV SI D ISDH fn KLED G KEWLH I A RIEQLYPFP AKGVKELF AK L P 874
Cdd:PRK09404 781 VS SLE EL A E GS FQPV IGDID - EL D PK KV K R V VL C SGKV YY D LLEA -- RRKR G IDDVA I V RIEQLYPFP HEELAAEL AK Y P 857
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 896112475 875 N L KE I VW V QEEP Q N M GAW GY I SPY L T E IA PEG VSVQ Y I GR RRRS SPA E G DPTV HKK E QE RI V S D S L T 941
Cdd:PRK09404 858 N A KE V VW C QEEP K N Q GAW YF I QHH L E E VL PEG QKLR Y A GR PASA SPA V G YMSL HKK Q QE AL V E D A L G 924
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
5-941
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1191.04
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 5 S MK QRMNWEDFY G P N LG Y AL ELY D QY TQ DP N S I DP DLKEM FD E L GAP P SDI --------------- K EAS G TKEKGRVTA 69
Cdd:COG0567 2 L MK AMDRSSFLS G A N AA Y IE ELY E QY LE DP D S V DP SWRAF FD G L PDV P GAR dfahspireefrkla K NGA G AAASAAADP 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 70 DLIQ K IASAVR L AEDI R TY GHL N A SVN PL RKD E KKS -- EL F P l SD YGLTE EEI kaipasvick D APK N ISN -- GLE A --- 142
Cdd:COG0567 82 EAAR K QVRVLQ L INAY R VR GHL F A KLD PL GLR E RPY vp EL D P - AF YGLTE ADL ---------- D TVF N TGS ll GLE T atl 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 143 --- I QY L RN TY KRT I SF E FD H VH D FK E RE W LTRKI ES GELFQKN SAE KLSAV LE R LT EV EGFE Q FLH RTF VGQKRFS I EG 219
Cdd:COG0567 151 rei I AA L KE TY CGS I GV E YM H IS D PE E KR W IQERL ES TRNRPSF SAE EKKRI LE K LT AA EGFE K FLH TKY VGQKRFS L EG 230
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 220 LDA L V P V LD DI I AQSVKS G TTSVN IGMAHRGRLNVL AHV LGKP YEI IFSEF qhapnkdlvps EG SIGISYGWT GDVKYHL 299
Cdd:COG0567 231 GES L I P A LD EL I ERAGEL G VKEIV IGMAHRGRLNVL VNI LGKP PRD IFSEF ----------- EG KSAEDVLGS GDVKYHL 299
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 300 G ANR elq D A ET -- KSARIT LA N NPSHLE FI NP I VEGS T RA A Q ET R TQSGY pvqde T K S L A ILIHGDAAF P G E G I V A ETLN 377
Cdd:COG0567 300 G FSS --- D V ET pg GKVHLS LA F NPSHLE IV NP V VEGS V RA R Q DR R GDTDR ----- D K V L P ILIHGDAAF A G Q G V V Y ETLN 371
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 378 L S S L K GY QV GG A IHI IA NN M IGFTT ESAES RS TK Y AS D L AK GYEI PI V HVN A DDPEA CLSAVKF A VE YR KT F N KD FL IDL 457
Cdd:COG0567 372 M S Q L R GY RT GG T IHI VI NN Q IGFTT SPRDA RS ST Y CT D V AK MVQA PI F HVN G DDPEA VVFVARL A LD YR QK F K KD VV IDL 451
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 458 IG YRR Y GHNE M DEP ST TQP ML Y DAVR KHPT VKQ I F A E KLV K EGV L T E E VVQNIEKSVTKRIEDAYQK V PSK K EHT A CEI E 537
Cdd:COG0567 452 VC YRR H GHNE G DEP AF TQP LM Y KKIK KHPT TRE I Y A D KLV A EGV I T A E EADEMVDEYRAALDEGFEV V KEY K PNK A DWL E 531
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 538 ----- LPEPVSNGFPD VDT SIDFDV L RK L NGE L INW PE S F NVFG K LKR ILE R R A K AFDDDRKVE W SL AE S LA F AS I L KD G 612
Cdd:COG0567 532 gdwsp YRRLGEDWDDP VDT GVPLEK L KE L GEK L TTL PE G F KLHP K VEK ILE D R R K MAEGEKPLD W GM AE A LA Y AS L L DE G 611
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 613 T P I RL T GQDS E RGTF AQ R NL VLHD SE TG KEF VPL H HLS DCSTS F A V H NS P LSE GS VLGFEYGY NVHS P E TLV L WEAQ Y GD 692
Cdd:COG0567 612 Y P V RL S GQDS G RGTF SH R HA VLHD QK TG ETY VPL N HLS EGQAR F E V Y NS L LSE EA VLGFEYGY ALAE P N TLV I WEAQ F GD 691
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 693 FAN A AQV YF DQFIS A G RA KWG QK SGLVMLLPHGYEGQGPEHSS G R I ERFLQL A AE N N WT V A N L T SA AQYFH I LRRQ A K ML 772
Cdd:COG0567 692 FAN G AQV VI DQFIS S G ES KWG RL SGLVMLLPHGYEGQGPEHSS A R L ERFLQL C AE D N MQ V C N P T TP AQYFH L LRRQ M K RP 771
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 773 L R eei R PL VI MTPKSLLR NPNT VS EVQ EL S E SR FQ P V YEQSG l SH D YE KV T R L VL S SGKV SI D ISDH fn KL E D G KEWLH I 852
Cdd:COG0567 772 F R --- K PL IV MTPKSLLR HKLA VS SLE EL A E GS FQ E V IDDTD - EL D PK KV K R V VL C SGKV YY D LLEE -- RR E R G RDDVA I 845
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 853 A RIEQLYPFP AKGVKELF AK L PN L KE I VW V QEEP Q NMGAW GY I SPY L T E IA P E G VSVQ Y I GR RRRS SPA E G DPT VHK K EQ 932
Cdd:COG0567 846 V RIEQLYPFP EEELAAEL AK Y PN A KE V VW C QEEP K NMGAW YF I QHR L E E VL P K G QRLR Y A GR PASA SPA T G YMS VHK A EQ 925
....*....
gi 896112475 933 ERI V SDS L T 941
Cdd:COG0567 926 KAL V EEA L G 934
TPP_E1_OGDC_like
cd02016 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed ...
201-479
1.07e-152
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of the tricarboxylic acid cycle.
Pssm-ID: 238974 [Multi-domain]
Cd Length: 265
Bit Score: 450.83
E-value: 1.07e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 201 FEQFL HRT F V GQKRF SI EG LDA L V P V LD DI I AQSVKS G TTS V N IGMAHRGRLNVLA H VLGKP Y E I IFSEF QHAPN kdlv P 280
Cdd:cd02016 1 FEQFL ATK F P GQKRF GL EG AES L I P A LD EL I DRAAEL G VEE V V IGMAHRGRLNVLA N VLGKP L E Q IFSEF EGKSE ---- F 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 281 S E GSI G I sygwt GDVKYHLG ANRELQDAET K SARIT LA N NPSHLE FI NP I V E G S TRA A Q ET R TQS gypvq DET K S L A ILI 360
Cdd:cd02016 77 P E DDE G S ----- GDVKYHLG YSSDRKTPSG K KVHLS LA P NPSHLE AV NP V V M G K TRA K Q DY R GDG ----- ERD K V L P ILI 146
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 361 HGDAAF P G E G I V A ETLNLS S L K GY QV GG A IHI IA NN M IGFTT ESAE SRS TK Y AS D L AK GYEI PI V HVN A DDPEA CLS A VK 440
Cdd:cd02016 147 HGDAAF A G Q G V V Y ETLNLS N L P GY TT GG T IHI VV NN Q IGFTT DPRD SRS SP Y CT D V AK MIGA PI F HVN G DDPEA VVR A TR 226
250 260 270
....*....|....*....|....*....|....*....
gi 896112475 441 F A V EYR KT F N KD FL IDL IG YRR Y GHNE M DEPS T TQP ML Y 479
Cdd:cd02016 227 L A L EYR QK F K KD VV IDL VC YRR H GHNE L DEPS F TQP LM Y 265
E1_dh
pfam00676 Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family ...
218-534
6.88e-110
Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.
Pssm-ID: 395548 [Multi-domain]
Cd Length: 300
Bit Score: 340.84
E-value: 6.88e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 218 EGLDA L VPVL D DII A QSVKS G TTSVNIGM A HRGRLN V LAHVLGK P YEI I FSEFQHAP N K d L VPSEGSIG I SYGWT G D V KY 297
Cdd:pfam00676 1 RRMMT L RRME D ARD A LYKRQ G IRGFYHLY A GQEAAQ V GIAAALE P GDY I IPGYRDHG N L - L ARGLSLEE I FAELY G R V AK 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 298 HL G ANRELQDAETKS a R ITLA N NPSHLE fi N P IVE G STR AA Q etrtqsgypv QDET K SL AI LIH GD A A f PGE G IVA E T LN 377
Cdd:pfam00676 80 GK G GSMHGYYGAKGN - R FYGG N GILGAQ -- V P LGA G IAL AA K ---------- YRGK K EV AI TLY GD G A - ANQ G DFF E G LN 145
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 378 LSS L KGYQ V gga I HIIA NN MI G FT T ESAESRSTKYAS D L A K GY E IP IV HV NAD DP E A CLS A V KFA V E YRK T FNKD FLI D L 457
Cdd:pfam00676 146 FAA L WKLP V --- I FVCE NN QY G IS T PAERASASTTYA D R A R GY G IP GL HV DGM DP L A VYQ A S KFA A E RAR T GKGP FLI E L 222
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 896112475 458 IG YR RY GH NEM D E PST TQ - PML Y DA VRK HPTVK Q I F A E K LV KE GV LT EE VVQN IEK S V T K RI E D A YQ K VP S KK E HTAC 534
Cdd:pfam00676 223 VT YR YG GH SMS D D PST YR t RDE Y EE VRK KKDPI Q R F K E H LV SK GV WS EE ELKA IEK E V R K EV E E A FK K AE S AP E PHPE 300
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
660-790
7.35e-22
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 92.16
E-value: 7.35e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 660 NSPLS E GSVL GF EY G YNV H S pet L VLWEAQYGD F ANA A QVYFDQFISA G RA kwgqk SGLVMLLPH G YE G Q - GP E H S S GRI 738
Cdd:smart00861 19 DTGIA E QAMV GF AA G LAL H G --- L RPVVEIFFT F FDR A KDQIRSAGAS G NV ----- PVVFRHDGG G GV G E d GP T H H S IED 90
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 896112475 739 E - RFLQLA aen NWT V ANLTSA A QYFHI LR RQ akml L R EEIRPLVIMTP KSL L R 790
Cdd:smart00861 91 E a LLRAIP --- GLK V VAPSDP A EAKGL LR AA ---- I R DDGPVVIRLER KSL Y R 136
Name
Accession
Description
Interval
E-value
2oxo_dh_E1
TIGR00239 2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists ...
17-940
0e+00
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists of this thiamine pyrophosphate-binding subunit (E1), dihydrolipoamide succinyltransferase (E2), and lipoamide dehydrogenase (E3). The E1 ortholog from Corynebacterium glutamicum is unusual in having an N-terminal extension that resembles the dihydrolipoamide succinyltransferase (E2) component of 2-oxoglutarate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 161785 [Multi-domain]
Cd Length: 929
Bit Score: 1488.59
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 17 G P N LG Y AL ELY DQ Y TQ DP N S I D PDLKEM FD E L GA P P ----------- S DIKEASGTKEK G R VT ADLIQKIA S A V RLAED I 85
Cdd:TIGR00239 4 G A N QS Y IE ELY ED Y LT DP D S V D ASWRST FD Q L PG P G papdqfhsptr S YFRRLAKDASR G S VT ISDPDTNV S Q V KVLQL I 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 86 R T Y --- GHL N A SVN PL R - K DEK K SELFP LS D YGLTE EEIK --- A I PAS V IC KDA PKNI SN g LE AI Q Y L RN TY KRT I SF E F 158
Cdd:TIGR00239 84 R A Y rfr GHL H A NLD PL G l K QQD K VPELD LS F YGLTE ADLQ etf N I GSF V SG KDA TMKL SN - LE LL Q A L KQ TY CGS I GA E Y 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 159 D H VHDFK E RE WL TRK IESGE LF Q K NS A EK LS a V L E RLT EV EGFE Q FL HRT F V G Q KRFS I EGLDALVP V L DD II AQ SV K SG 238
Cdd:TIGR00239 163 M H ITSTE E KR WL QQR IESGE RA Q F NS E EK KR - F L S RLT AA EGFE R FL GAK F P G A KRFS L EGLDALVP M L KE II RH SV N SG 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 239 T TS V NI GMAHRGRLNVL AH VLGKP Y E I IFSEF QHAPNKD L VPS egsigisygw TGDVKYH L G ANRELQDAET K SARIT LA 318
Cdd:TIGR00239 242 T RD V VL GMAHRGRLNVL VN VLGKP P E D IFSEF AGKHKSH L PDG ---------- TGDVKYH M G RFSSDFTTDG K LVHLA LA 311
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 319 N NPSHLE FIN P I V E GSTRA AQETRTQ S gypv QDE TK S LAILIHGDAAF P G E G I V A ETLN L S S L K GY Q VGG A IHII A NN M I 398
Cdd:TIGR00239 312 F NPSHLE IVS P V V I GSTRA RLDRLND S ---- PES TK V LAILIHGDAAF A G Q G V V Q ETLN M S K L R GY S VGG T IHII I NN Q I 387
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 399 GFTT ESAES RST K Y A SDLAK GYEI PI V HVNADDPEA CLS A VKF AVEYR K TF NK D FL IDL I GYRR Y GHNE M DEPS T TQP ML 478
Cdd:TIGR00239 388 GFTT NPLDA RST P Y C SDLAK MIQA PI F HVNADDPEA VAF A TRL AVEYR N TF KR D VF IDL V GYRR H GHNE A DEPS A TQP LM 467
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 479 Y DAVR KHPT VKQIF A E KLV K EGV L TEE V V QNIEKSVTKRI E D A YQK VPS KK E - H TA CEI --- EL PEPVSNGF P DVDTSID 554
Cdd:TIGR00239 468 Y QKIK KHPT PRKVY A D KLV S EGV A TEE D V TEMVNLYRDAL E A A DCV VPS WR E m N TA SFT wsp EL NHEWDEEY P NKVEMKR 547
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 555 FDV L R K LNG E lin W PE SFNVFGKLKR I LER R A KA - FDDDRKVE W SL AE S LAFA SILK DG T P I RL T G Q DSERGTF A QR NL V 633
Cdd:TIGR00239 548 LQE L A K RIS E --- V PE GVEMHSRVAK I YFD R T KA m AAGEKLFD W GG AE N LAFA TLVD DG I P V RL S G E DSERGTF F QR HA V 624
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 634 LHD SET G KEFV PL H HL SDCSTS F A V H NS P LSE G SVLGFEYGY NVH SP E TLV L WEAQ Y GDFAN A AQV YF DQFIS A G RA KWG 713
Cdd:TIGR00239 625 LHD QSN G STYT PL Q HL HNGQGA F R V W NS V LSE E SVLGFEYGY ATT SP R TLV I WEAQ F GDFAN G AQV VI DQFIS S G EQ KWG 704
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 714 Q K SGLVMLLPHGYEGQGPEHSSGR I ERFLQLAAE N N WT V ANL T SA AQ Y FHILRRQA kml LR EEI RPLV I M T PKSLLR N P N 793
Cdd:TIGR00239 705 Q M SGLVMLLPHGYEGQGPEHSSGR L ERFLQLAAE Q N MQ V CVP T TP AQ V FHILRRQA --- LR GMR RPLV V M S PKSLLR H P L 781
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 794 T VS EVQ EL S E SR FQPV Y --- E Q SGLS H D Y E K V T RLVL S SGKV SI D I sd H FNKLED G KEWLH I A RIEQLYPFP A K G VKE LF 870
Cdd:TIGR00239 782 A VS SLE EL A E GT FQPV I gei E E SGLS L D P E G V K RLVL C SGKV YY D L -- H EQRRKN G QKDVA I V RIEQLYPFP H K A VKE VL 859
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 871 AKL PNLKEIVW V QEEP Q NMGAW G Y IS P Y L T E IA PEGVSV Q Y I GR RRRS SPA E G DPTV H K K E Q ERIVS D S L 940
Cdd:TIGR00239 860 QQY PNLKEIVW C QEEP L NMGAW Y Y SQ P H L R E VI PEGVSV R Y A GR PASA SPA V G YMSL H Q K Q Q QDLLN D A L 929
sucA
PRK09404 2-oxoglutarate dehydrogenase E1 component; Reviewed
3-941
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1433.75
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 3 QNS MK QRMNWEDFY G P N LG Y AL ELY D QY TQ DP N S I D PDLKEM FD E L GAPPS D IKEASGTKE ------ KG RV TADLIQKIA 76
Cdd:PRK09404 2 NSA MK AWLDSSFLF G A N AA Y IE ELY E QY LK DP D S V D EEWRAF FD G L PGVAP D VAHSAVRES frrlak PA RV SSAVSDPQV 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 77 SAVR L AEDI R TY GHL N A SVN PL RKDEKKS - ELFPLSD YGLTE EEIKAIPASVICKDAPKN i SNGL E A I QY L RN TY KRT I S 155
Cdd:PRK09404 82 KVLQ L INAY R FR GHL A A NLD PL GLWKRPD v PELDPAF YGLTE ADLDRTFNTGSLALGKET - ATLR E I I EA L KK TY CGS I G 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 156 F E FD H VH D FK ER E WL TRK IESG EL fq KN SAE KLS A V LERLT EV EGFE Q FLH RT FVGQKRFS I EG LDA L V P V LD D II AQSV 235
Cdd:PRK09404 161 V E YM H IS D PE ER R WL QQR IESG RP -- SF SAE EKK A I LERLT AA EGFE R FLH TK FVGQKRFS L EG GES L I P M LD E II RRAG 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 236 K S G TTSVN IGMAHRGRLNVL AH VLGKP YEII F S EF QHAPNK D lvpsegsigi SYGWT GDVKYHLG ANRELQD a ETKSARI 315
Cdd:PRK09404 239 K L G VKEIV IGMAHRGRLNVL VN VLGKP PRDL F A EF EGKHGP D ---------- EVLGS GDVKYHLG FSSDRET - DGGEVHL 307
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 316 T LA N NPSHLE FI NP I VEGS T RA A Q ET R tqsg YPV QD ET K S L A ILIHGDAAF P G E G I VAETLNLS S L K GY QV GG A IHI IA N 395
Cdd:PRK09404 308 S LA F NPSHLE IV NP V VEGS V RA R Q DR R ---- GDG QD RK K V L P ILIHGDAAF A G Q G V VAETLNLS Q L R GY RT GG T IHI VI N 383
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 396 N M IGFTT ESAES RST K Y AS D L AK GYEI PI V HVN A DDPEA CLS A VKF A V EYR KT F N KD FL IDL IG YRR Y GHNE M DEPS T TQ 475
Cdd:PRK09404 384 N Q IGFTT SPPDD RST P Y CT D V AK MVQA PI F HVN G DDPEA VVF A TRL A L EYR QK F K KD VV IDL VC YRR H GHNE G DEPS F TQ 463
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 476 P ML Y DAVR KHPT VKQIF A E KLV K EGV L TEE VVQNIEKSVTKRIEDAYQK V PSKKEHTACEIE - L P EPVSNGFPD VDT SID 554
Cdd:PRK09404 464 P LM Y KKIK KHPT TRELY A D KLV A EGV I TEE EADEMVNEYRDALDAGFEV V KEWRPADWLAGD w S P YLGHEWDDP VDT GVP 543
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 555 FDV L RK L NGE L INW PE S F N V FG K L K R ILE R R AKAFDDDRKVE W SL AE S LAFAS I L KD G T P I RL T GQDS E RGTF AQ R NL VL 634
Cdd:PRK09404 544 LER L KE L AEK L TTV PE G F K V HP K V K K ILE D R REMAEGEKPID W GM AE A LAFAS L L DE G Y P V RL S GQDS G RGTF SH R HA VL 623
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 635 HD SE TG KEFV PL H HLS DCST SF A V HN SPLSE GS VLGFEYGY NVHS P E TLV L WEAQ Y GDFAN A AQV YF DQFIS A G RA KWG Q 714
Cdd:PRK09404 624 HD QK TG ETYI PL N HLS EGQA SF E V YD SPLSE EA VLGFEYGY STAE P N TLV I WEAQ F GDFAN G AQV VI DQFIS S G EQ KWG R 703
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 715 K SGLVMLLPHGYEGQGPEHSS G R I ERFLQL A AE N N WT V A N L T SA AQYFH I LRRQA K mll R EEIR PLV I MTPKSLLR N P NT 794
Cdd:PRK09404 704 L SGLVMLLPHGYEGQGPEHSS A R L ERFLQL C AE D N MQ V C N P T TP AQYFH L LRRQA L --- R PFRK PLV V MTPKSLLR H P LA 780
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 795 VS EVQ EL S E SR FQPV YEQSG l SH D YE KV T R L VL S SGKV SI D ISDH fn KLED G KEWLH I A RIEQLYPFP AKGVKELF AK L P 874
Cdd:PRK09404 781 VS SLE EL A E GS FQPV IGDID - EL D PK KV K R V VL C SGKV YY D LLEA -- RRKR G IDDVA I V RIEQLYPFP HEELAAEL AK Y P 857
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 896112475 875 N L KE I VW V QEEP Q N M GAW GY I SPY L T E IA PEG VSVQ Y I GR RRRS SPA E G DPTV HKK E QE RI V S D S L T 941
Cdd:PRK09404 858 N A KE V VW C QEEP K N Q GAW YF I QHH L E E VL PEG QKLR Y A GR PASA SPA V G YMSL HKK Q QE AL V E D A L G 924
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
5-941
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1191.04
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 5 S MK QRMNWEDFY G P N LG Y AL ELY D QY TQ DP N S I DP DLKEM FD E L GAP P SDI --------------- K EAS G TKEKGRVTA 69
Cdd:COG0567 2 L MK AMDRSSFLS G A N AA Y IE ELY E QY LE DP D S V DP SWRAF FD G L PDV P GAR dfahspireefrkla K NGA G AAASAAADP 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 70 DLIQ K IASAVR L AEDI R TY GHL N A SVN PL RKD E KKS -- EL F P l SD YGLTE EEI kaipasvick D APK N ISN -- GLE A --- 142
Cdd:COG0567 82 EAAR K QVRVLQ L INAY R VR GHL F A KLD PL GLR E RPY vp EL D P - AF YGLTE ADL ---------- D TVF N TGS ll GLE T atl 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 143 --- I QY L RN TY KRT I SF E FD H VH D FK E RE W LTRKI ES GELFQKN SAE KLSAV LE R LT EV EGFE Q FLH RTF VGQKRFS I EG 219
Cdd:COG0567 151 rei I AA L KE TY CGS I GV E YM H IS D PE E KR W IQERL ES TRNRPSF SAE EKKRI LE K LT AA EGFE K FLH TKY VGQKRFS L EG 230
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 220 LDA L V P V LD DI I AQSVKS G TTSVN IGMAHRGRLNVL AHV LGKP YEI IFSEF qhapnkdlvps EG SIGISYGWT GDVKYHL 299
Cdd:COG0567 231 GES L I P A LD EL I ERAGEL G VKEIV IGMAHRGRLNVL VNI LGKP PRD IFSEF ----------- EG KSAEDVLGS GDVKYHL 299
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 300 G ANR elq D A ET -- KSARIT LA N NPSHLE FI NP I VEGS T RA A Q ET R TQSGY pvqde T K S L A ILIHGDAAF P G E G I V A ETLN 377
Cdd:COG0567 300 G FSS --- D V ET pg GKVHLS LA F NPSHLE IV NP V VEGS V RA R Q DR R GDTDR ----- D K V L P ILIHGDAAF A G Q G V V Y ETLN 371
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 378 L S S L K GY QV GG A IHI IA NN M IGFTT ESAES RS TK Y AS D L AK GYEI PI V HVN A DDPEA CLSAVKF A VE YR KT F N KD FL IDL 457
Cdd:COG0567 372 M S Q L R GY RT GG T IHI VI NN Q IGFTT SPRDA RS ST Y CT D V AK MVQA PI F HVN G DDPEA VVFVARL A LD YR QK F K KD VV IDL 451
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 458 IG YRR Y GHNE M DEP ST TQP ML Y DAVR KHPT VKQ I F A E KLV K EGV L T E E VVQNIEKSVTKRIEDAYQK V PSK K EHT A CEI E 537
Cdd:COG0567 452 VC YRR H GHNE G DEP AF TQP LM Y KKIK KHPT TRE I Y A D KLV A EGV I T A E EADEMVDEYRAALDEGFEV V KEY K PNK A DWL E 531
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 538 ----- LPEPVSNGFPD VDT SIDFDV L RK L NGE L INW PE S F NVFG K LKR ILE R R A K AFDDDRKVE W SL AE S LA F AS I L KD G 612
Cdd:COG0567 532 gdwsp YRRLGEDWDDP VDT GVPLEK L KE L GEK L TTL PE G F KLHP K VEK ILE D R R K MAEGEKPLD W GM AE A LA Y AS L L DE G 611
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 613 T P I RL T GQDS E RGTF AQ R NL VLHD SE TG KEF VPL H HLS DCSTS F A V H NS P LSE GS VLGFEYGY NVHS P E TLV L WEAQ Y GD 692
Cdd:COG0567 612 Y P V RL S GQDS G RGTF SH R HA VLHD QK TG ETY VPL N HLS EGQAR F E V Y NS L LSE EA VLGFEYGY ALAE P N TLV I WEAQ F GD 691
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 693 FAN A AQV YF DQFIS A G RA KWG QK SGLVMLLPHGYEGQGPEHSS G R I ERFLQL A AE N N WT V A N L T SA AQYFH I LRRQ A K ML 772
Cdd:COG0567 692 FAN G AQV VI DQFIS S G ES KWG RL SGLVMLLPHGYEGQGPEHSS A R L ERFLQL C AE D N MQ V C N P T TP AQYFH L LRRQ M K RP 771
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 773 L R eei R PL VI MTPKSLLR NPNT VS EVQ EL S E SR FQ P V YEQSG l SH D YE KV T R L VL S SGKV SI D ISDH fn KL E D G KEWLH I 852
Cdd:COG0567 772 F R --- K PL IV MTPKSLLR HKLA VS SLE EL A E GS FQ E V IDDTD - EL D PK KV K R V VL C SGKV YY D LLEE -- RR E R G RDDVA I 845
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 853 A RIEQLYPFP AKGVKELF AK L PN L KE I VW V QEEP Q NMGAW GY I SPY L T E IA P E G VSVQ Y I GR RRRS SPA E G DPT VHK K EQ 932
Cdd:COG0567 846 V RIEQLYPFP EEELAAEL AK Y PN A KE V VW C QEEP K NMGAW YF I QHR L E E VL P K G QRLR Y A GR PASA SPA T G YMS VHK A EQ 925
....*....
gi 896112475 933 ERI V SDS L T 941
Cdd:COG0567 926 KAL V EEA L G 934
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
43-942
0e+00
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 1037.93
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 43 E M F DE L GA P -- P ---- S DI KEAS gtkekgrvt A D LIQ K I A SAVR L AEDI R TY GHL N A SVN PL R - KDEKKSE L FP L S d Y GL 115
Cdd:PRK12270 357 E I F ES L RI P ye P vrwa T DI PADH --------- E D EVD K N A RVME L IHAY R VR GHL M A DTD PL E y RQRSHPD L DV L T - H GL 426
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 116 T ---- EE E IKA ipasvickdapknis N G L --------- EAIQY LR NT Y K RT ISF E FD H VH D FKE R E WL TRKI E SG el FQ K 182
Cdd:PRK12270 427 T lwdl DR E FPV --------------- G G F ggkermklr DILGV LR DS Y C RT VGI E YM H IQ D PEQ R R WL QERV E RP -- HE K 489
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 183 NSA E KLSAV L ER L TEV E G FE Q FL HRTF VGQKRFS I EG LDA L V P V LD DIIA Q SVKS G TTS V N IGMAHRGRLNVLA HVL GKP 262
Cdd:PRK12270 490 PTR E EQKRI L SK L NAA E A FE T FL QTKY VGQKRFS L EG GES L I P L LD AVLD Q AAEH G LDE V V IGMAHRGRLNVLA NIV GKP 569
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 263 Y EI IF S EF qhapnkdlvps EG SI - GI S YGWT GDVKYHLGA NRELQDAETKSARIT LA N NPSHLE FIN P IV EG ST RA A Q ET 341
Cdd:PRK12270 570 Y SQ IF R EF ----------- EG NL d PR S AQGS GDVKYHLGA EGTFTQMFGDEIKVS LA A NPSHLE AVD P VL EG IV RA K Q DR 638
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 342 RTQ -- S G YP V qdetks L A IL I HGDAAF P G E G I VAETLNLS S L K GY QV GG A IHI IA NN MI GFTT ESAE SRS TK YA S D L AK G 419
Cdd:PRK12270 639 LDK ge E G FT V ------ L P IL L HGDAAF A G Q G V VAETLNLS Q L R GY RT GG T IHI VV NN QV GFTT APES SRS SE YA T D V AK M 712
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 420 YEI PI V HVN A DDPEA CLSAVKF A V EYR KT F N KD FL IDL IG YRR Y GHNE M D E PS T TQP ML YD AVRKHPT V KQIFA E K L VKE 499
Cdd:PRK12270 713 IQA PI F HVN G DDPEA VVRVARL A F EYR QR F H KD VV IDL VC YRR R GHNE G D D PS M TQP LM YD LIDAKRS V RKLYT E A L IGR 792
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 500 G VL T E E VVQNIEKSVTKRI E DAYQK V PSKKEHTACEI E LP E PVSNGFPD VDT SIDFD VL RKLNGELI N W PE S F N V FG KLK 579
Cdd:PRK12270 793 G DI T V E EAEQALRDYQGQL E RVFNE V REAEKKPPEPP E SV E SDQGPPAG VDT AVSAE VL ERIGDAHV N L PE G F T V HP KLK 872
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 580 RI LE R R AKAFDDD r KVE W SLA E S LAF A S I L KD GTP I RL T GQDS E RGTF A QR NL VL H D S ETG K E FV PL HH LSD CSTS F A V H 659
Cdd:PRK12270 873 PL LE K R REMAREG - GID W AFG E L LAF G S L L LE GTP V RL S GQDS R RGTF S QR HA VL I D R ETG E E YT PL QN LSD DQGK F L V Y 951
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 660 N S P LSE GSVL GFEYGY N V HS P ET LVLWEAQ Y GDFAN A AQ VYF D Q FIS A G R AKWGQ K SG L V M LLPHGYEGQGP E HSS G RIE 739
Cdd:PRK12270 952 D S L LSE YAAM GFEYGY S V ER P DA LVLWEAQ F GDFAN G AQ TII D E FIS S G E AKWGQ R SG V V L LLPHGYEGQGP D HSS A RIE 1031
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 740 RFLQL A AE N N W TVA NLTSA A Q YFH I LRRQA kml L REEI RPLV IM TPKS L LR NPNT VS E V QELS E SR F Q PV YEQSGLS h D Y 819
Cdd:PRK12270 1032 RFLQL C AE G N M TVA QPSTP A N YFH L LRRQA --- L SGPR RPLV VF TPKS M LR LKAA VS D V EDFT E GK F R PV IDDPTVD - D G 1107
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 820 E KV T R LV L S SGK VSI D ISDH fn KLE DG KEWLH I A R I EQLYP F P AKGVK E LF A KL PN LK E I VWVQEEP Q N M GAW GYISPY L 899
Cdd:PRK12270 1108 A KV R R VL L C SGK LYY D LAAR -- REK DG RDDTA I V R V EQLYP L P RAELR E AL A RY PN AT E V VWVQEEP A N Q GAW PFMALN L 1185
890 900 910 920
....*....|....*....|....*....|....*....|...
gi 896112475 900 T E IA P E G VSVQYIG R RRRS SPA E G DPT VH KK EQ ERIVSDSLT R 942
Cdd:PRK12270 1186 P E LL P D G RRLRRVS R PASA SPA T G SAK VH AV EQ QELLDEAFA R 1228
TPP_E1_OGDC_like
cd02016 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed ...
201-479
1.07e-152
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of the tricarboxylic acid cycle.
Pssm-ID: 238974 [Multi-domain]
Cd Length: 265
Bit Score: 450.83
E-value: 1.07e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 201 FEQFL HRT F V GQKRF SI EG LDA L V P V LD DI I AQSVKS G TTS V N IGMAHRGRLNVLA H VLGKP Y E I IFSEF QHAPN kdlv P 280
Cdd:cd02016 1 FEQFL ATK F P GQKRF GL EG AES L I P A LD EL I DRAAEL G VEE V V IGMAHRGRLNVLA N VLGKP L E Q IFSEF EGKSE ---- F 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 281 S E GSI G I sygwt GDVKYHLG ANRELQDAET K SARIT LA N NPSHLE FI NP I V E G S TRA A Q ET R TQS gypvq DET K S L A ILI 360
Cdd:cd02016 77 P E DDE G S ----- GDVKYHLG YSSDRKTPSG K KVHLS LA P NPSHLE AV NP V V M G K TRA K Q DY R GDG ----- ERD K V L P ILI 146
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 361 HGDAAF P G E G I V A ETLNLS S L K GY QV GG A IHI IA NN M IGFTT ESAE SRS TK Y AS D L AK GYEI PI V HVN A DDPEA CLS A VK 440
Cdd:cd02016 147 HGDAAF A G Q G V V Y ETLNLS N L P GY TT GG T IHI VV NN Q IGFTT DPRD SRS SP Y CT D V AK MIGA PI F HVN G DDPEA VVR A TR 226
250 260 270
....*....|....*....|....*....|....*....
gi 896112475 441 F A V EYR KT F N KD FL IDL IG YRR Y GHNE M DEPS T TQP ML Y 479
Cdd:cd02016 227 L A L EYR QK F K KD VV IDL VC YRR H GHNE L DEPS F TQP LM Y 265
E1_dh
pfam00676 Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family ...
218-534
6.88e-110
Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.
Pssm-ID: 395548 [Multi-domain]
Cd Length: 300
Bit Score: 340.84
E-value: 6.88e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 218 EGLDA L VPVL D DII A QSVKS G TTSVNIGM A HRGRLN V LAHVLGK P YEI I FSEFQHAP N K d L VPSEGSIG I SYGWT G D V KY 297
Cdd:pfam00676 1 RRMMT L RRME D ARD A LYKRQ G IRGFYHLY A GQEAAQ V GIAAALE P GDY I IPGYRDHG N L - L ARGLSLEE I FAELY G R V AK 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 298 HL G ANRELQDAETKS a R ITLA N NPSHLE fi N P IVE G STR AA Q etrtqsgypv QDET K SL AI LIH GD A A f PGE G IVA E T LN 377
Cdd:pfam00676 80 GK G GSMHGYYGAKGN - R FYGG N GILGAQ -- V P LGA G IAL AA K ---------- YRGK K EV AI TLY GD G A - ANQ G DFF E G LN 145
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 378 LSS L KGYQ V gga I HIIA NN MI G FT T ESAESRSTKYAS D L A K GY E IP IV HV NAD DP E A CLS A V KFA V E YRK T FNKD FLI D L 457
Cdd:pfam00676 146 FAA L WKLP V --- I FVCE NN QY G IS T PAERASASTTYA D R A R GY G IP GL HV DGM DP L A VYQ A S KFA A E RAR T GKGP FLI E L 222
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 896112475 458 IG YR RY GH NEM D E PST TQ - PML Y DA VRK HPTVK Q I F A E K LV KE GV LT EE VVQN IEK S V T K RI E D A YQ K VP S KK E HTAC 534
Cdd:pfam00676 223 VT YR YG GH SMS D D PST YR t RDE Y EE VRK KKDPI Q R F K E H LV SK GV WS EE ELKA IEK E V R K EV E E A FK K AE S AP E PHPE 300
Transket_pyr
pfam02779 Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate ...
593-790
5.62e-49
Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases.
Pssm-ID: 460692 [Multi-domain]
Cd Length: 174
Bit Score: 171.19
E-value: 5.62e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 593 R K VEWSL A ESL A F A SIL K DGTPIRLT G Q D SER GTF AQRNLV LH DSET G K efvplhhlsdcstsfa V HNSPLS E GSVL GF E 672
Cdd:pfam02779 1 K K IATRK A SGE A L A ELA K RDPRVVGG G A D LAG GTF TVTKGL LH PQGA G R ---------------- V IDTGIA E QAMV GF A 64
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 673 Y G YNV H S P e T L VLW EA QYG DF A N aaqv YF D QF I SA G R A KWGQKSG - L V MLL P H G YEGQ GP E H S S GRIER FL QLAA en NWT 751
Cdd:pfam02779 65 N G MAL H G P - L L PPV EA TFS DF L N ---- RA D DA I RH G A A LGKLPVP f V V TRD P I G VGED GP T H Q S VEDLA FL RAIP -- GLK 137
170 180 190
....*....|....*....|....*....|....*....
gi 896112475 752 V ANLTS AA QYFHI LR RQ akm LL R EEIR P L V IMT P KS LLR 790
Cdd:pfam02779 138 V VRPSD AA ETKGL LR AA --- IR R DGRK P V V LRL P RQ LLR 173
OxoGdeHyase_C
pfam16870 2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately ...
795-940
3.99e-45
2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately C-terminal to Transket_pyr, pfam02779. It is found at the C-terminus of 2-oxoglutarate dehydrogenase.
Pssm-ID: 465289 [Multi-domain]
Cd Length: 147
Bit Score: 159.14
E-value: 3.99e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 795 V S EVQ E LSE - SR FQ P V YEQSGLSH D Y EKV T R L VL S SGKV SI D ISDHFNKLEDG K E w LH I A RIEQLYPFP AKGV KE LFA K L 873
Cdd:pfam16870 1 R S SLE E FTP g TH FQ R V IPDPEPLV D P EKV K R V VL C SGKV YY D LLKEREERGGI K D - VA I V RIEQLYPFP FDLL KE ELD K Y 79
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 896112475 874 PN LK EIVW V QEEP Q N M GAW GYIS P Y L TEIAP E - G VSVQ Y I GR RRRS SPA E G DPT VH KK EQE RIVS D SL 940
Cdd:pfam16870 80 PN AA EIVW C QEEP K N Q GAW SFVQ P R L ETVLN E t G HRLR Y A GR PPSA SPA T G SKS VH LA EQE ALLD D AF 147
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
660-790
7.35e-22
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 92.16
E-value: 7.35e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 660 NSPLS E GSVL GF EY G YNV H S pet L VLWEAQYGD F ANA A QVYFDQFISA G RA kwgqk SGLVMLLPH G YE G Q - GP E H S S GRI 738
Cdd:smart00861 19 DTGIA E QAMV GF AA G LAL H G --- L RPVVEIFFT F FDR A KDQIRSAGAS G NV ----- PVVFRHDGG G GV G E d GP T H H S IED 90
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 896112475 739 E - RFLQLA aen NWT V ANLTSA A QYFHI LR RQ akml L R EEIRPLVIMTP KSL L R 790
Cdd:smart00861 91 E a LLRAIP --- GLK V VAPSDP A EAKGL LR AA ---- I R DDGPVVIRLER KSL Y R 136
TPP_E1_PDC_ADC_BCADC
cd02000 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; ...
351-525
1.48e-21
Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain alpha-keto acid dehydrogenase/2-oxoisovalerate dehydrogenase complex (BCADC). PDC catalyzes the irreversible oxidative decarboxylation of pyruvate to produce acetyl-CoA in the bridging step between glycolysis and the citric acid cycle. ADC participates in the breakdown of acetoin while BCADC participates in the breakdown of branched chain amino acids. BCADC catalyzes the oxidative decarboxylation of 4-methyl-2-oxopentanoate, 3-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate (branched chain 2-oxo acids derived from the transamination of leucine, valine and isoleucine).
Pssm-ID: 238958 [Multi-domain]
Cd Length: 293
Bit Score: 96.03
E-value: 1.48e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 351 DETKSL A ILIH GD A A f PG EG IVA E T LN LSS L KGYQ V gga I HIIA NN MIGFT T ESAESRSTKYAS D L A KG Y E IP IVH V NAD 430
Cdd:cd02000 123 RGEDRV A VCFF GD G A - TN EG DFH E A LN FAA L WKLP V --- I FVCE NN GYAIS T PTSRQTAGTSIA D R A AA Y G IP GIR V DGN 198
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896112475 431 D PE A CLS A V K F AVE Y - R KT f NKDF LI DLIG YR RY GH NEM D E PS T -- T QPMLYDAVRKH P TVK qi FAEK L VKE G V LTEE VV 507
Cdd:cd02000 199 D VL A VYE A A K E AVE R a R AG - GGPT LI EAVT YR LG GH STS D D PS R yr T KEEVEEWKKRD P ILR -- LRKY L IEA G I LTEE EL 275
170
....*....|....*...
gi 896112475 508 QN IE KS V TKRI E D A YQKV 525
Cdd:cd02000 276 AA IE AE V KAEV E E A VEFA 293
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
13-78
7.25e-06
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 50.27
E-value: 7.25e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 896112475 13 ED F y G P N LGYAL E L Y D QY TQ DPNS I DP DLK E M F DEL G APPSDIKE A SGTKEKGRVT A DLIQKI A S A 78
Cdd:PRK12270 2 SE F - G Q N EWLVE E M Y Q QY LA DPNS V DP SWR E F F ADY G PGSTAAPT A AAAAAAAAAS A PAAAPA A K A 66
2-oxogl_dehyd_N
pfam16078 2-oxoglutarate dehydrogenase N-terminus; This domain is found at the N-terminus of ...
15-52
4.67e-05
2-oxoglutarate dehydrogenase N-terminus; This domain is found at the N-terminus of 2-oxoglutarate dehydrogenases.
Pssm-ID: 465008 [Multi-domain]
Cd Length: 41
Bit Score: 41.36
E-value: 4.67e-05
10 20 30
....*....|....*....|....*....|....*...
gi 896112475 15 FY G P N LG Y AL ELY D QY TQ DP N S I DP DLKEM FD E L GAPP 52
Cdd:pfam16078 4 LS G A N AA Y IE ELY E QY LK DP S S V DP SWRAY FD N L DDGE 41
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
