|
Name |
Accession |
Description |
Interval |
E-value |
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
6-427 |
0e+00 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 603.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 6 SMFSRMLWFLAAVLVVYQFVSYATFYNYLLSPTVKQISHLLANQVKLIFP---IDSKQLALSEDAEALVYVATGSDIYTQ 82
Cdd:PRK09467 7 SSFARTLLLIVTLLFISQVVSYLVVLNYAILPSLQQFNKVLAYEVRLLFTdqlEDGTQLVVPPAFRREIYRELGISLYSN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 83 SEAEQHGLNESKPYTYLEESISHELKGQTKVRVEIQ-DHYIIWIQPPQANQMWVRIPLTEIEDDDIEPLILYMSVLLVVT 161
Cdd:PRK09467 87 EAAEEAGLRWAQHYEFLSEQMSQQLGGPTEVRVEVGkESPIVWIKTPLAPNIWVRVPLTEIHQGDFSPLFRYTLAIGLLS 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 162 LFAAWRFARQLVRPLEDLEAGAVAVARGNFPDALGEQGSREVRRLTRTFNHMSSSIKRLIEERNMMMAGVSHDLRTPLTR 241
Cdd:PRK09467 167 VAGGWLFIRIQNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMAAGIKQLEDDRTLLMAGVSHDLRTPLTR 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 242 IRLATEMMSSGDEYLKESINADIDESNGIIDQFIDYIRPDEGLDTQQIDLTQLIHDALLMQTDQGLEVELILPEQAVRVA 321
Cdd:PRK09467 247 IRLATEMMSEEDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNALLGEVIAAESGYEREIETALQPGPIEVP 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 322 CNPISIRRILNNLSGNSLRYGATRLQAELKDDGHWVRLRLSDNGPGIPAQDHSRVLKPFTQGNVARTGGGSGLGLAIVAK 401
Cdd:PRK09467 327 MNPIAIKRALANLVVNAARYGNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSSGTGLGLAIVKR 406
|
410 420
....*....|....*....|....*.
gi 914776602 402 IVSQHHGTIRLGDAELGGLLVEIRLP 427
Cdd:PRK09467 407 IVDQHNGKVELGNSEEGGLSARAWLP 432
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
115-429 |
1.40e-54 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 184.34 E-value: 1.40e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 115 VEIQDHYIIWIQPPQANQMWVRIPLTEIEDDDIEPLILYMSVLLVVTLFAAWRFARQLVRPLEDLEAGAVAVARGNFPDA 194
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 195 LGEQGSREVRRLTRTFNHMSSSIKRLIEERNMMMAGVSHDLRTPLTRIRLATEMMSSG-----DEYLkESINADIDESNG 269
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEEldeeqREYL-ETILRSADRLLR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 270 IIDQFIDYIRPDEG---LDTQQIDLTQLIHDALLMQT----DQGLEVELILPEQAVRVACNPISIRRILNNLSGNSLRYG 342
Cdd:COG0642 160 LINDLLDLSRLEAGkleLEPEPVDLAELLEEVVELFRplaeEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 343 A--TRLQAELKDDGHWVRLRLSDNGPGIPAQDHSRVLKPFTQGNVARTGGGSGLGLAIVAKIVSQHHGTIRLGDAELGGL 420
Cdd:COG0642 240 PegGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGT 319
|
....*....
gi 914776602 421 LVEIRLPKH 429
Cdd:COG0642 320 TFTVTLPLA 328
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
218-431 |
8.91e-51 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 171.63 E-value: 8.91e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 218 KRLIEERNMMMAGVSHDLRTPLTRIRLATEMMSSGD--------EYLkESINADIDESNGIIDQFIDYIRPDEG---LDT 286
Cdd:COG2205 10 EELERLKSEFLANVSHELRTPLTSILGAAELLLDEEdlspeerrELL-EIIRESAERLLRLIEDLLDLSRLESGklsLEL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 287 QQIDLTQLIHDAL----LMQTDQGLEVELILPEQAVRVACNPISIRRILNNLSGNSLRYG--ATRLQAELKDDGHWVRLR 360
Cdd:COG2205 89 EPVDLAELLEEAVeelrPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSppGGTITISARREGDGVRIS 168
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 914776602 361 LSDNGPGIPAQDHSRVLKPFTQGNVARTGGGSGLGLAIVAKIVSQHHGTIRLGDAELGGLLVEIRLPKHQP 431
Cdd:COG2205 169 VSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAES 239
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
129-431 |
7.32e-49 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 171.27 E-value: 7.32e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 129 QANQMWVRIPLTEIEDDDIEPLILYMSVLLVVTLFAAWRFARQLVRPLEDLEAGAVAVARGNFPDALGEQGSREVRRLTR 208
Cdd:COG5002 70 LLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLA 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 209 TFNHMSSSIKRLIEERNMMMAGVSHDLRTPLTRIRLATEMMSSGDEYLKE-------SINADIDESNGIIDQFIDYIRPD 281
Cdd:COG5002 150 AVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEerreyleIILEEAERLSRLVNDLLDLSRLE 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 282 EG---LDTQQIDLTQLIHDAL----LMQTDQGLEVELILPEQAVRVACNPISIRRILNNLSGNSLRYGA--TRLQAELKD 352
Cdd:COG5002 230 SGelkLEKEPVDLAELLEEVVeelrPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPegGTITVSLRE 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 353 DGHWVRLRLSDNGPGIPAQDHSRVLKPFTQGNVART--GGGSGLGLAIVAKIVSQHHGTIRLGDAELGGLLVEIRLPKHQ 430
Cdd:COG5002 310 EDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSreTGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLAR 389
|
.
gi 914776602 431 P 431
Cdd:COG5002 390 E 390
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
149-431 |
9.05e-44 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 158.94 E-value: 9.05e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 149 PLILYMSVLLVVTLFAAWrFARQLVRPLEDLEAGAVAVARGNF---PDAlgEQGSREVRRLTRTFNHMSSSIKRLIEERN 225
Cdd:PRK09470 168 PLLLLLVTMLVSTPLLLW-LAWSLAKPARKLKNAADEVAQGNLrqhPEL--ETGPQEFRQAGASFNQMVTALERMMTSQQ 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 226 MMMAGVSHDLRTPLTRIRLATEMMS--SGdeylkesinadidESNGIidqfidyirpdEGLDTQQIDLTQLIHDALL--- 300
Cdd:PRK09470 245 RLLSDISHELRTPLTRLQLATALLRrrQG-------------ESKEL-----------ERIETEAQRLDSMINDLLVlsr 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 301 MQTDQGLEVELI----------------------------LPEQAVrVACNPISIRRILNNLSGNSLRYGATRLQAELKD 352
Cdd:PRK09470 301 NQQKNHLERETFkanslwsevledakfeaeqmgksltvsaPPGPWP-INGNPNALASALENIVRNALRYSHTKIEVAFSV 379
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 353 DGHWVRLRLSDNGPGIPAQDHSRVLKPFTQGNVART--GGGSGLGLAIVAKIVSQHHGTIRLGDAELGGLLVEIRLPKHQ 430
Cdd:PRK09470 380 DKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDreSGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLPLYK 459
|
.
gi 914776602 431 P 431
Cdd:PRK09470 460 R 460
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
166-432 |
3.96e-42 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 153.99 E-value: 3.96e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 166 WRFARQLVRPLEDLEAGAVAvARGNFPDALGeqgsreVRRLTRTFNHMSSSIKRLIEERNMMMAGVSHDLRTPLTRIRLA 245
Cdd:PRK10604 161 WQDMLKLEAAAQRLGDGHLA-ERIHFDEGSS------LERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYR 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 246 TEMMSSGDEYLKESINADIDESNGIIDQFIDYI---RPDEGLDTQQIDLTQLIHDAL--LMQTDQGLEVELILPEQAVRV 320
Cdd:PRK10604 234 LEMSDNLSAAESQALNRDIGQLEALIEELLTYArldRPQNELHLSEPDLPAWLSTHLadIQAVTPEKTVRLDTPHQGDYG 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 321 ACNPISIRRILNNLSGNSLRYGATRLQAELKDDGHWVRLRLSDNGPGIPAQDHSRVLKPFTQGNVA--RTGGGSGLGLAI 398
Cdd:PRK10604 314 ALDMRLMERVLDNLLNNALRYAHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSrdRATGGCGLGLAI 393
|
250 260 270
....*....|....*....|....*....|....
gi 914776602 399 VAKIVSQHHGTIRLGDAELGGLLVEIRLPKHQPL 432
Cdd:PRK10604 394 VHSIALAMGGSVNCDESELGGARFSFSWPVWHNL 427
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
150-431 |
6.00e-38 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 142.41 E-value: 6.00e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 150 LILYMSVLLVVTLFAAWRFARQLVRPLEDLEAGAVAVARGNFPDALGEQGSREVRRLTRTFNHMSSSIKRL---IEERNM 226
Cdd:COG5000 11 LLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQreeLEERRR 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 --------------------------------------------------------------------------------
Cdd:COG5000 91 yletilenlpagvivldadgritlanpaaerllgipleeligkpleellpeldlaellrealergwqeeieltrdgrrtl 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 227 ---------------------------------MMAGVSHDLRTPLTRIRLATEMM--------SSGDEYLKESINADID 265
Cdd:COG5000 171 lvrasplrddgyvivfdditellraerlaawgeLARRIAHEIKNPLTPIQLSAERLrrkladklEEDREDLERALDTIIR 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 266 ESNG---IIDQFIDYIRPDEgLDTQQIDLTQLIHDAL-LMQTD---QGLEVELILPEQAVRVACNPISIRRILNNLSGNS 338
Cdd:COG5000 251 QVDRlkrIVDEFLDFARLPE-PQLEPVDLNELLREVLaLYEPAlkeKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNA 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 339 LRygAT----RLQAELKDDGHWVRLRLSDNGPGIPAQDHSRVLKPF--TQGNvartggGSGLGLAIVAKIVSQHHGTIRL 412
Cdd:COG5000 330 IE--AIeeggEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFftTKPK------GTGLGLAIVKKIVEEHGGTIEL 401
|
410
....*....|....*....
gi 914776602 413 GDAELGGLLVEIRLPKHQP 431
Cdd:COG5000 402 ESRPGGGTTFTIRLPLAEE 420
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
122-429 |
3.27e-33 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 128.38 E-value: 3.27e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 122 IIWIQPPQANQMWVRIPLTEIEDDDIEPLILYMSVLLVVTLFAAWRFARQLVRPLEDLEAGAVAVARGNFPDALGEQGSR 201
Cdd:COG4191 28 LLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 202 EVRRLTRTFNHMSSSIKRLIEERNMMM------------AGVSHDLRTPLTRIRLATEMM------SSGDEYLKE---SI 260
Cdd:COG4191 108 ELEELERDITELERAEEELRELQEQLVqseklaalgelaAGIAHEINNPLAAILGNAELLrrrledEPDPEELREaleRI 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 261 NADIDESNGIIDQFIDYIRPDEgLDTQQIDLTQLIHDAL-LMQT---DQGLEVELILPEQAVRVACNPISIRRILNNLSG 336
Cdd:COG4191 188 LEGAERAAEIVRSLRAFSRRDE-EEREPVDLNELIDEALeLLRPrlkARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLI 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 337 NSL------RYGatRLQAELKDDGHWVRLRLSDNGPGIPAQDHSRVLKPF--TQgnvaRTGGGSGLGLAIVAKIVSQHHG 408
Cdd:COG4191 267 NAIdameegEGG--RITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFftTK----PVGKGTGLGLSISYGIVEKHGG 340
|
330 340
....*....|....*....|.
gi 914776602 409 TIRLGDAELGGLLVEIRLPKH 429
Cdd:COG4191 341 RIEVESEPGGGTTFTITLPLA 361
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
150-433 |
6.74e-30 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 120.89 E-value: 6.74e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 150 LILYMSVLLvvTLFAAWRFARQLVRPLEDLEAGAVAVARGNFPDALGEQGSREVRRLTRTFNHMSSSIKRLIEERNMMMA 229
Cdd:PRK10549 168 LIVALSTLL--AALATFLLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLEKNEQMRRDFMA 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 230 GVSHDLRTPLTRIRLATEMMSSG-DEYLKESINADIDESnGIIDQFIDYIR----PDEG---LDTQQIDLTQLIHDALL- 300
Cdd:PRK10549 246 DISHELRTPLAVLRGELEAIQDGvRKFTPESVASLQAEV-GTLTKLVDDLHqlslSDEGalaYRKTPVDLVPLLEVAGGa 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 301 ---MQTDQGLEVELILPEQAVRVAcNPISIRRILNNLSGNSLRYGAT--RLQAELKDDGHWVRLRLSDNGPGIPAQDHSR 375
Cdd:PRK10549 325 freRFASRGLTLQLSLPDSATVFG-DPDRLMQLFNNLLENSLRYTDSggSLHISAEQRDKTLRLTFADSAPGVSDEQLQK 403
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 376 VLKPF--TQGNVARTGGGSGLGLAIVAKIVSQHHGTIRLGDAELGGLLVEIRLPKHQPLE 433
Cdd:PRK10549 404 LFERFyrTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQ 463
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-427 |
1.95e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 104.84 E-value: 1.95e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 327 IRRILNNLSGNSLRYGatRLQAELKDDGHWVRLRLS--DNGPGIPAQDHSRVLKPFTQGNVARTGGGSGLGLAIVAKIVS 404
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQvlDNGPGIAPEEVDELFQPFYRGDNARGTSGTGLGLAIVQRISD 78
|
90 100
....*....|....*....|...
gi 914776602 405 QHHGTIRLGDAELGGLLVEIRLP 427
Cdd:cd16950 79 AHGGSLTLANRAGGGLCARIELP 101
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
327-426 |
1.37e-26 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 102.68 E-value: 1.37e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 327 IRRILNNLSGNSLRYGA--TRLQAELKDDGHWVRLRLSDNGPGIPAQDHSRVLKPFTQGNVARTGGGSGLGLAIVAKIVS 404
Cdd:cd00075 1 LEQVLSNLLDNALKYSPpgGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|..
gi 914776602 405 QHHGTIRLGDAELGGLLVEIRL 426
Cdd:cd00075 81 AHGGRITVESEPGGGTTFTVTL 102
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
156-410 |
3.22e-26 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 110.50 E-value: 3.22e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 156 VLLVVTLFA-AWRFARQLVRPLEDLEAGAVAVARGNFPDALGEQGSREVRRLTRTFNHMSSSIKRLIEERNMM------- 227
Cdd:NF040691 195 LALVVLLGLiAWLVTRQVVAPVRSAARTAERFAAGDLSERMPVKGEDDLARLARSFNQMADSLQRQIRQLEELsrlqqrf 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 228 MAGVSHDLRTPLTRIRLATEMMSSGDEYLK-------ESINADIDESNGIIDQFIDYIRPDEG---LDTQQIDLTQLIHD 297
Cdd:NF040691 275 VSDVSHELRTPLTTIRMAADVIHDSRDDFDpatarsaELLHTELDRFESLLSDLLEISRFDAGaaeLDVEPVDLRPLVRR 354
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 298 AL----LMQTDQGLEVELILPEQAVRVACNPISIRRILNNLSGNSLRYGATR-LQAELKDDGHWVRLRLSDNGPGIPAQD 372
Cdd:NF040691 355 VVdalrQLAERAGVELRVDAPGTPVVAEVDPRRVERVLRNLVVNAIEHGEGKpVVVTVAQDDTAVAVTVRDHGVGLKPGE 434
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 914776602 373 HSRVLKPFTQGNVAR--TGGGSGLGLAIVAKIVSQHHGTI 410
Cdd:NF040691 435 VALVFDRFWRADPARarTTGGTGLGLAIALEDARLHGGWL 474
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
202-431 |
4.63e-26 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 108.40 E-value: 4.63e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 202 EVRRLTRTFNHMS--SSIKRLIeernmmmAGVSHDLRTPLTRIRLATEMMSS--GDEYLKESINADIDES---NGIIDQF 274
Cdd:COG3852 118 ERKRLERELRRAEklAAVGELA-------AGLAHEIRNPLTGIRGAAQLLERelPDDELREYTQLIIEEAdrlNNLVDRL 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 275 IDYIRPDEgLDTQQIDLTQLIHDAL-LMQTD--QGLEVELILPEQAVRVACNPISIRRILNNLSGN-------------S 338
Cdd:COG3852 191 LSFSRPRP-PEREPVNLHEVLERVLeLLRAEapKNIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNaaeampeggtitiR 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 339 LRYgATRLQAELKDDGHWVRLRLSDNGPGIPAQDHSRVLKPFtqgnVARTGGGSGLGLAIVAKIVSQHHGTIRLgDAELG 418
Cdd:COG3852 270 TRV-ERQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPF----FTTKEKGTGLGLAIVQKIVEQHGGTIEV-ESEPG 343
|
250
....*....|....
gi 914776602 419 -GLLVEIRLPKHQP 431
Cdd:COG3852 344 kGTTFRIYLPLEQA 357
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
323-428 |
5.42e-26 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 101.19 E-value: 5.42e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 323 NPISIRRILNNLSGNSLRYG--ATRLQAELKDDGHWVRLRLSDNGPGIPAQDHSRVLKPFTQG-NVARTGGGSGLGLAIV 399
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYTpeGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTdKRSRKIGGTGLGLSIV 81
|
90 100
....*....|....*....|....*....
gi 914776602 400 AKIVSQHHGTIRLGDAELGGLLVEIRLPK 428
Cdd:smart00387 82 KKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
231-431 |
6.50e-26 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 109.87 E-value: 6.50e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 231 VSHDLRTPLTRIRLATEMMSS---------GDEYLkESINADIDESNGIIDQFIDYIRPD-EGLDTQQIDLTQLIHDAL- 299
Cdd:COG4251 289 ASHDLREPLRKISGFSQLLEEdygdkldeeGREYL-ERIRDAAERMQALIDDLLAYSRVGrQELEFEPVDLNELLEEVLe 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 300 -LMQTDQGLEVELI---LPEqavrVACNPISIRRILNNLSGNSLRYGATRLQAEL----KDDGHWVRLRLSDNGPGIPAQ 371
Cdd:COG4251 368 dLEPRIEERGAEIEvgpLPT----VRGDPTLLRQVFQNLISNAIKYSRPGEPPRIeigaEREGGEWVFSVRDNGIGIDPE 443
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 372 DHSRVLKPFTQGNVARTGGGSGLGLAIVAKIVSQHHGTIRLGDAELGGLLVEIRLPKHQP 431
Cdd:COG4251 444 YAEKIFEIFQRLHSRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKAPA 503
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
323-430 |
2.93e-25 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 99.36 E-value: 2.93e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 323 NPISIRRILNNLSGNSLRYGATRLQAELK-DDGHWVRLRLSDNGPGIPAQDHSRVLKPFTQGNVaRTGGGSGLGLAIVAK 401
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTlSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK-RGGGGTGLGLSIVRK 80
|
90 100
....*....|....*....|....*....
gi 914776602 402 IVSQHHGTIRLGDAELGGLLVEIRLPKHQ 430
Cdd:pfam02518 81 LVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
150-429 |
4.79e-25 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 106.85 E-value: 4.79e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 150 LILYMSVLLVVTLFAAWrfarqLVRPLEDLEAGAVAVARGNfPDALGEQGSREVRRLTRTFNHMSSSI--KRLIEE--RN 225
Cdd:PRK11100 189 ALLLGIALLIGAGVVWW-----LNRSIRRLTRYADAVTEGK-PVPLPKLGSSELRELAQALESMRVKLegKAYVEQyvQT 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 226 MmmagvSHDLRTPLTRIRLATEMmssgdeyLKESINAD--------IDESNGIIDQFIDYI--------RPDEgLDTQQI 289
Cdd:PRK11100 263 L-----THELKSPLAAIRGAAEL-------LQEDPPPEdrarftgnILTQSARLQQLIDRLlelarleqRQEL-EVLEPV 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 290 DLTQLIHDALLMQTDQ----GLEVELILPEqaVRVACNPISIRRILNNLSGNSLRY----GATRLQAELKDDGhwVRLRL 361
Cdd:PRK11100 330 ALAALLEELVEAREAQaaakGITLRLRPDD--ARVLGDPFLLRQALGNLLDNAIDFspegGTITLSAEVDGEQ--VALSV 405
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 914776602 362 SDNGPGIPAQDHSRVLKPFTqgNVARTGGG---SGLGLAIVAKIVSQHHGTIRLGDAELGGLLVEIRLPKH 429
Cdd:PRK11100 406 EDQGPGIPDYALPRIFERFY--SLPRPANGrksTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRH 474
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
329-427 |
6.10e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 95.57 E-value: 6.10e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 329 RILNNLSGNSLRYGATRLQAELKDDGHWVRLRLSDNGPGIPAQDHSRVLKPFTQGNVART--GGGSGLGLAIVAKIVSQH 406
Cdd:cd16939 3 RALDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDraTGGFGLGLAIVHRVALWH 82
|
90 100
....*....|....*....|.
gi 914776602 407 HGTIRLGDAELGGLLVEIRLP 427
Cdd:cd16939 83 GGHVECDDSELGGACFRLTWP 103
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
227-431 |
8.00e-24 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 103.52 E-value: 8.00e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 227 MMAGVSHDLRTPLTRIR-----LATEMMSSGDEYLkESINADIDESNGIIDQFIDYIRPDEGlDTQQIDLTQLIHDAL-L 300
Cdd:COG5809 273 LAAGIAHEIRNPLTSLKgfiqlLKDTIDEEQKTYL-DIMLSELDRIESIISEFLVLAKPQAI-KYEPKDLNTLIEEVIpL 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 301 MQTD---QGLEVELILPEQAVRVACNPISIRRILNNLSGNSL----RYGATRLQAELKDDGHwVRLRLSDNGPGIPAQDH 373
Cdd:COG5809 351 LQPQallKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIeampEGGNITIETKAEDDDK-VVISVTDEGCGIPEERL 429
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 914776602 374 SRVLKPF--TQGNvartggGSGLGLAIVAKIVSQHHGTIRLgDAELG-GLLVEIRLPKHQP 431
Cdd:COG5809 430 KKLGEPFytTKEK------GTGLGLMVSYKIIEEHGGKITV-ESEVGkGTTFSITLPIKLS 483
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
150-411 |
1.50e-23 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 102.47 E-value: 1.50e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 150 LILYMSVLLVVTLFAAWRFARQLVRPLEDLEAGAVAVARGNFPDALGEQG-SREVRRLTRTFNHMSSSIKRLIEERNMMM 228
Cdd:TIGR01386 166 LILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPSRaPAELRELAQSFNAMLGRLEDAFQRLSQFS 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 229 AGVSHDLRTPLTRIRLATEMM----SSGDEYlKESINADIDESN---GIIDQFIDYIRPDEG---LDTQQIDLTQLIHDA 298
Cdd:TIGR01386 246 ADLAHELRTPLTNLLGQTQVAlsqpRTGEEY-REVLESNLEELErlsRMVSDMLFLARADNGqlaLERVRLDLAAELAKV 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 299 L----LMQTDQGLEVELilpEQAVRVACNPISIRRILNNLSGNSLRYGA--TRLQAELKDDGHWVRLRLSDNGPGIPAQD 372
Cdd:TIGR01386 325 AeyfePLAEERGVRIRV---EGEGLVRGDPQMFRRAISNLLSNALRHTPdgGTITVRIERRSDEVRVSVSNPGPGIPPEH 401
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 914776602 373 HSRVLKPFTQGNVART--GGGSGLGLAIVAKIVSQHHGTIR 411
Cdd:TIGR01386 402 LSRLFDRFYRVDPARSnsGEGTGLGLAIVRSIMEAHGGRAS 442
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
221-430 |
2.37e-22 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 98.67 E-value: 2.37e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 221 IEERNMMMAGVSHDLRTPLTRIRLATEMMSSGDEYLKES-----INADIDESNGIIDQFIDYIRPdEGLDTQQIDLTQLI 295
Cdd:COG5808 238 LELIGTFAASTAHEIRNPLTSIKGFIQLLQEKYPELEDQkyfdiIQEEIQRINQIVSEFLVLGKP-TAKKLELDDLNELI 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 296 HDALLM----QTDQGLEVELILPEQAVRVACNPISIRRILNNLSGNSLRYGATR--LQAELKDDGHWVRLRLSDNGPGIP 369
Cdd:COG5808 317 EEILSIidseANLKNIRVEKQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAMKEGgkLTISIENDDEKAVIEVIDNGEGIP 396
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 914776602 370 AQDHSRVLKPFtqgnVARTGGGSGLGLAIVAKIVSQHHGTIRLGDAELGGLLVEIRLPKHQ 430
Cdd:COG5808 397 EDIIDEIFEPF----VTTKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRLPLKK 453
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
329-428 |
1.62e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 88.92 E-value: 1.62e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 329 RILNNLSGNSLRYGATRLQAELKDDGHWVRLRLSDNGPGIPAQDHSRVLKPFTQGNVART--GGGSGLGLAIVAKIVSQH 406
Cdd:cd16949 3 RALENVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDreSGGTGLGLAIAERAIEQH 82
|
90 100
....*....|....*....|..
gi 914776602 407 HGTIRLGDAELGGLLVEIRLPK 428
Cdd:cd16949 83 GGKIKASNRKPGGLRVRIWLPA 104
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
156-428 |
4.07e-21 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 93.88 E-value: 4.07e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 156 VLLVVTLFAAWRFARQLVRPLEDLEAGAVAVARGNFpDALGEQGS-REVRRLTRTFNHMSSSIKRLIEERNMMMAGVSHD 234
Cdd:PRK10755 69 VMVSLTLLICFQAVRWITRPLAELQKELEARTADNL-TPIAIHSStLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHE 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 235 LRTPLTRIRLATEMMSSGDEYLKESINADIDESNGIIDQFIDYIRPDEGLDT---QQIDLTQLIHDALLMQTDQGLE--- 308
Cdd:PRK10755 148 LRTPLAGIRLHLELLEKQHHIDVAPLIARLDQMMHTVEQLLQLARAGQSFSSghyQTVKLLEDVILPSQDELSEMLEqrq 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 309 VELILPE--QAVRVACNPISIRRILNNLSGNSLRYG--ATRLQAELKDDGHWVRLRLSDNGPGIPAQDHSRVLKPFTQgn 384
Cdd:PRK10755 228 QTLLLPEsaADITVQGDATLLRLLLRNLVENAHRYSpeGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVR-- 305
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 914776602 385 VARTGGGSGLGLAIVAKIVSQHHGTIRLGD-AELGGLLVEIRLPK 428
Cdd:PRK10755 306 MDSRYGGIGLGLSIVSRITQLHHGQFFLQNrQERSGTRAWVWLPK 350
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
323-427 |
1.87e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 85.98 E-value: 1.87e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 323 NPISIRRILNNLSGNSLRY----GATRLQAELKDDGhwVRLRLSDNGPGIPAQDHSRVLKPFTQGNVART--GGGSGLGL 396
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYtdtgGKLRIRAAQTPQE--VRLDVEDSAPGVSDDQLARLFERFYRVESSRNraSGGSGLGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 914776602 397 AIVAKIVSQHHGTIRLGDAELGGLLVEIRLP 427
Cdd:cd16946 79 AICHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
202-433 |
1.75e-19 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 91.25 E-value: 1.75e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 202 EVRRLTRTFNHM-SSSIKRL----IEE-----------RNMMMAGVSHDLRTPLTRIRLATEMM-----SSGDEYLKES- 259
Cdd:PRK10490 626 EQQRLLETFTLLiANALERLtltaSEEqarlasereqlRNALLAALSHDLRTPLTVLFGQAEILtldlaSEGSPHARQAs 705
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 260 -INADIDESNGIIDQFIDYIRPDEG---LDTQQIDLTQLIHDALLM--QTDQGLEVELILPEQAVRVACNPISIRRILNN 333
Cdd:PRK10490 706 eIRQQVLNTTRLVNNLLDMARIQSGgfnLRKEWLTLEEVVGSALQMlePGLSGHPINLSLPEPLTLIHVDGPLFERVLIN 785
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 334 LSGNSLRYGATRLQAELKD--DGHWVRLRLSDNGPGIPAQDHSRVLKPFTQGNVARTGGGSGLGLAIVAKIVSQHHGTIR 411
Cdd:PRK10490 786 LLENAVKYAGAQAEIGIDAhvEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGGTIW 865
|
250 260
....*....|....*....|..
gi 914776602 412 LGDAELGGLLVEIRLPKHQPLE 433
Cdd:PRK10490 866 AENRPEGGACFRVTLPLETPPE 887
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
215-410 |
2.48e-19 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 88.42 E-value: 2.48e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 215 SSIKRLIEERNMMMAGVSHDLRTPLTRIRLATEMMSSG----DEYLKESINADIDES---NGIIDQFIDYIR---PDEGL 284
Cdd:TIGR02966 105 TRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGpdedPEEWNRALEIMLEQSqrmQSLVEDLLTLSRlesAASPL 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 285 DTQQIDLTQLI----HDALLMQTDQGLEVELILpEQAVRVACNPISIRRILNNLSGNSLRY----GATRLQAELKDDGhw 356
Cdd:TIGR02966 185 EDEPVDMPALLdhlrDEAEALSQGKNHQITFEI-DGGVDVLGDEDELRSAFSNLVSNAIKYtpegGTITVRWRRDGGG-- 261
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 914776602 357 VRLRLSDNGPGIPAQDHSRVLKPFTQGNVAR--TGGGSGLGLAIVAKIVSQHHGTI 410
Cdd:TIGR02966 262 AEFSVTDTGIGIAPEHLPRLTERFYRVDKSRsrDTGGTGLGLAIVKHVLSRHHARL 317
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
227-427 |
3.07e-19 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 90.03 E-value: 3.07e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 227 MMAGVSHDLRTPLTRIRLATEMMSSGD------EYLKEsINADIDESNGIIDQFIDYIRPDEgLDTQQIDLTQLIHDAL- 299
Cdd:PRK11360 393 LVAGVAHEIRNPLTAIRGYVQIWRQQTsdppsqEYLSV-VLREVDRLNKVIDQLLEFSRPRE-SQWQPVSLNALVEEVLq 470
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 300 LMQT---DQGLEVELILPEQAVRVACNPISIRRILNNLSGNSL----RYGATRLQAELKDDGHwVRLRLSDNGPGIPAQD 372
Cdd:PRK11360 471 LFQTagvQARVDFETELDNELPPIWADPELLKQVLLNILINAVqaisARGKIRIRTWQYSDGQ-VAVSIEDNGCGIDPEL 549
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 914776602 373 HSRVLKPF--TQGNvartggGSGLGLAIVAKIVSQHHGTIRLgDAELG-GLLVEIRLP 427
Cdd:PRK11360 550 LKKIFDPFftTKAK------GTGLGLALSQRIINAHGGDIEV-ESEPGvGTTFTLYLP 600
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
150-425 |
4.21e-19 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 88.94 E-value: 4.21e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 150 LILYMSVLLVVTLFAAWRFARQLvRPLEDLEAGAvavaRGNFPDA---LGEQG-SREVRRLTRTFNHMSSSI-KRLIEER 224
Cdd:PRK10337 164 LIPWLVALPIMLIILMVLLGREL-APLKKLALAL----RMRDPDSetpLNATGvPSEVRPLVEALNQLFARThAMMVRER 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 225 NMMmAGVSHDLRTPLTRIRLATEM--MSSGDEYLKE----SINADIDESNGIIDQFIDYIRPDEG---LDTQQIDLTQLI 295
Cdd:PRK10337 239 RFT-SDAAHELRSPLAALKVQTEVaqLSDDDPQARKkallQLHAGIDRATRLVDQLLTLSRLDSLdnlQDVAEIPLEDLL 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 296 HDALLMQ--TDQ--GLEVELILPEQAVRVACNPISIRRILNNLSGNSLRYGATRLQAELKDDGHwvRLRLSDNGPGIPAQ 371
Cdd:PRK10337 318 QSAVMDIyhTAQqaGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNAR--NFTVRDNGPGVTPE 395
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 914776602 372 DHSRVLKPFTqgnvaRTGG----GSGLGLAIVAKIVSQHHGTIRLGDAELGGLLVEIR 425
Cdd:PRK10337 396 ALARIGERFY-----RPPGqeatGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKVS 448
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
315-426 |
9.41e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 81.30 E-value: 9.41e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 315 EQAVRVACNPISIRRILNNLSGNSLRYG--ATRLQAELKDDGHWVrLRLSDNGPGIPAQDHSRVLKPFTQGNvARTGGGS 392
Cdd:cd16940 2 AADIQVQGDALLLFLLLRNLVDNAVRYSpqGSRVEIKLSADDGAV-IRVEDNGPGIDEEELEALFERFYRSD-GQNYGGS 79
|
90 100 110
....*....|....*....|....*....|....
gi 914776602 393 GLGLAIVAKIVSQHHGTIRLGDAELGGLLVEIRL 426
Cdd:cd16940 80 GLGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
227-428 |
1.68e-17 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 84.40 E-value: 1.68e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 227 MMAGVSHDLRTPLTRIRLATEMMSSGDEYLKESINADIDE---SNGIIDQFIDYIRPDEgLDTQQIDLTQLIHDAL-LMQ 302
Cdd:COG5805 290 LAAGIAHEIRNPLTSIKGFLQLLQPGIEDKEEYFDIMLSEldrIESIISEFLALAKPQA-VNKEKENINELIQDVVtLLE 368
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 303 TD---QGLEVELILPEQAVRVACNPISIRRILNNLSGNSLRY---GATrLQAELKDDGHWVRLRLSDNGPGIPAQDHSRV 376
Cdd:COG5805 369 TEailHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAmpnGGT-ITIHTEEEDNSVIIRVIDEGIGIPEERLKKL 447
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 914776602 377 LKPF--TQGNvartggGSGLGLAIVAKIVSQHHGTIRLgDAELG-GLLVEIRLPK 428
Cdd:COG5805 448 GEPFftTKEK------GTGLGLMVSYKIIENHNGTIDI-DSKVGkGTTFTITLPL 495
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
327-427 |
2.29e-17 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 77.53 E-value: 2.29e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 327 IRRILNNLSGNSLRY----GATRLQAElKDDGHWVRLRLSDNGPGIPAQDHSRVLKPFTQG--NVARTGGGSGLGLAIVA 400
Cdd:cd16925 5 YERVVLNLLSNAFKFtpdgGRIRCILE-KFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGdgSSTRAHGGTGLGLSIVK 83
|
90 100
....*....|....*....|....*..
gi 914776602 401 KIVSQHHGTIRLGDAELGGLLVEIRLP 427
Cdd:cd16925 84 EFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
100-433 |
2.48e-17 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 84.69 E-value: 2.48e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 100 EESISHELKGQTK--VRVEIQDHYIIWIQ-PPQANQMWVRIPLTEIEDDDIEPLI------LYMSVLLVVTLFaaWRFAR 170
Cdd:PRK15347 242 LQKILNQLENVKLhdGWQQIPDYLVLRTQlKGPGWQQVTLYPRRNLANEALKPALqqlpfaLLILVLLTSVLF--LLLRR 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 171 QLVRPLedleAGAVAVARGNFPDA----LGEQGSREVRRLTRTFNHMSSSI---------------------KRLIEERN 225
Cdd:PRK15347 320 YLAKPL----WRFVDIINKTGPAAleprLPENRLDELGSIAKAYNQLLDTLneqydtlenkvaertqalaeaKQRAEQAN 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 226 MM----MAGVSHDLRTPLTRIRLATEMMSSGDEYLKESINADI-----DESNGIIDQFIDYIRPDEG---LDTQQIDLTQ 293
Cdd:PRK15347 396 KRksehLTTISHEIRTPLNGVLGALELLQNTPLTAEQMDLADTarqctLSLLAIINNLLDFSRIESGqmtLSLEETALLP 475
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 294 LIHDAllMQTDQGLEVE-------LILPEQAVRVACNPISIRRILNNLSGNSLRY---GATRLQAELKDDghwvRL--RL 361
Cdd:PRK15347 476 LLDQA--MLTIQGPAQSksltlrtFVGAHVPLYLHLDSLRLRQILVNLLGNAVKFtetGGIRLRVKRHEQ----QLcfTV 549
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 914776602 362 SDNGPGIPAQDHSRVLKPFTQgnVARTGGGSGLGLAIVAKIVSQHHGTIRLgDAELG-GLLVEIRLP--KHQPLE 433
Cdd:PRK15347 550 EDTGCGIDIQQQQQIFTPFYQ--ADTHSQGTGLGLTIASSLAKMMGGELTL-FSTPGvGSCFSLVLPlnEYAPPE 621
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
202-429 |
3.31e-17 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 83.67 E-value: 3.31e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 202 EVRRLTRTFNHMSSSIKRLIEERNMMMAGVSHDLRTPLTRIRLATEMMSSGD---EYLKESINADIDESNGIIDQFIDYi 278
Cdd:PRK09835 240 ELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSrsqKELEDVLYSNLEELTRMAKMVSDM- 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 279 rpdegLDTQQIDLTQLIHDALLMQTDQGL--------------EVELILPEQAVRVACNPISIRRILNNLSGNSLRY--G 342
Cdd:PRK09835 319 -----LFLAQADNNQLIPEKKMLDLADEVgkvfdffeawaeerGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYtpA 393
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 343 ATRLQAELKDDGHWVRLRLSDNGPGIPAQDHSRVLKPFTQGNVAR--TGGGSGLGLAIVAKIVSQHHGTIRLgDAELGGL 420
Cdd:PRK09835 394 GEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRqrKGEGSGIGLAIVKSIVVAHKGTVAV-TSDARGT 472
|
....*....
gi 914776602 421 LVEIRLPKH 429
Cdd:PRK09835 473 RFVISLPRL 481
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
229-427 |
3.57e-17 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 83.30 E-value: 3.57e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 229 AGVSHDLRTPLTRIR-LAT---EMMSSG--DEYLKESINADIDESNGIIDQFIDYIRPDEgLDTQQIDLTQLIHDAL-LM 301
Cdd:PRK10364 242 AGVAHEIRNPLSSIKgLAKyfaERAPAGgeAHQLAQVMAKEADRLNRVVSELLELVKPTH-LALQAVDLNDLINHSLqLV 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 302 QTD---QGLEVELILPEQAVRVACNPISIRRILNNLSGNSL----RYGATRLQAELKDDGhwVRLRLSDNGPGIPAQDHS 374
Cdd:PRK10364 321 SQDansREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIqaigQHGVISVTASESGAG--VKISVTDSGKGIAADQLE 398
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 914776602 375 RVLKP-FTQgnvarTGGGSGLGLAIVAKIVSQHHGTIRLGDAELGGLLVEIRLP 427
Cdd:PRK10364 399 AIFTPyFTT-----KAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
327-427 |
9.74e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 75.61 E-value: 9.74e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 327 IRRILNNLSGNSLRY---GATRLQAEL---KDDGHWVRLRLSDNGPGIPAQDHSRVLKPFTQGNVARTG--GGSGLGLAI 398
Cdd:cd16922 1 LRQILLNLLGNAIKFteeGEVTLRVSLeeeEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRkyGGTGLGLAI 80
|
90 100 110
....*....|....*....|....*....|
gi 914776602 399 VAKIVSQHHGTIRLgDAELG-GLLVEIRLP 427
Cdd:cd16922 81 SKKLVELMGGDISV-ESEPGqGSTFTFTLP 109
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
4-428 |
1.06e-14 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 75.82 E-value: 1.06e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 4 VSSMFSRMLWFLAAVLVVYQFVSYATFYNYLLSPTVKQISHLLANQVKLIFPIDSKQLALSEDAEALVYVATGSDIYTQS 83
Cdd:COG2972 14 LLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLLLLLLLLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 84 EAEQHGLNESKPYTYLEESISHELKgqtkVRVEIQDHYIIWIQPPQANQMWVRIPLTEIEDDDIEP---LILYMSVLLVV 160
Cdd:COG2972 94 ILLLSLLLLLALILLLALLLLLSIL----LLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLrrlILLIILLLLLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 161 TLFAAWRFARQLVRPLEDLEAGAVAVARGNFPDaLGEQGSREVRRLTRTFNHMSSSIKRLIEERNMMMAGVS-------- 232
Cdd:COG2972 170 ALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVR-LEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKKeaelkalq 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 233 -----HDLRTPLTRIRlateMMSsgdeylkesINADIDESNGIIDQFIDYIR----PDEGLDT--QQIDLTQLIHDALLM 301
Cdd:COG2972 249 aqinpHFLFNTLNSIR----WLA---------ELEDPEEAEEMLEALSKLLRyslsKGDELVTleEELELIKSYLEIQKL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 302 QTDQGLEVELILPEQAVRVACnpisIRRILNNLSGNSLRYGATRLQAELK------DDGHWVRLRLSDNGPGIPAQDHSR 375
Cdd:COG2972 316 RFGDRLEVEIEIDEELLDLLI----PKLILQPLVENAIEHGIEPKEGGGTirisirKEGDRLVITVEDNGVGMPEEKLEK 391
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 914776602 376 VLKPFtqgnvARTGGGSGLGLAIVAKIVSQHHG---TIRLGDAELGGLLVEIRLPK 428
Cdd:COG2972 392 LLEEL-----SSKGEGRGIGLRNVRERLKLYYGeeyGLEIESEPGEGTTVTIRIPL 442
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
330-427 |
1.35e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 69.24 E-value: 1.35e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 330 ILNNLSGNSL------RYGATRLQAELKDDGHWVRLRLSDNGPGIPAQDHSRVlkpFTQGNVARTGGGSGLGLAIVAKIV 403
Cdd:cd16915 4 IVGNLIDNALdalaatGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKV---FERGVSTKGQGERGIGLALVRQSV 80
|
90 100
....*....|....*....|....
gi 914776602 404 SQHHGTIRLGDAELGGLLVEIRLP 427
Cdd:cd16915 81 ERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
304-426 |
5.61e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 68.43 E-value: 5.61e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 304 DQGLEVELILPEqAVRVACNPISIRRILNNLSGNSLRYGATRLQAELKDDGHWVRLRLSDNGPGIPAQDHSRVLKPFTQG 383
Cdd:cd16954 16 RKGVSISLDISP-ELRFPGERNDLMELLGNLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRL 94
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 914776602 384 NVARTGggSGLGLAIVAKIVSQHHGTIRLGDAELGGLLVEIRL 426
Cdd:cd16954 95 DEQRPG--QGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
271-428 |
8.36e-14 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 72.57 E-value: 8.36e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 271 IDQFIDYIRpDEGLDTQQIDLTQLIH------DALLMQ-----TDQGLEVELILPEQAVRVACNPISIRRILNNLSGNSL 339
Cdd:COG3290 216 YDEALEYID-EISEELQELIDSLLSRignpvlAALLLGkaaraRERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAI 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 340 RY------GATRLQAELKDDGHWVRLRLSDNGPGIPAQDHSRVlkpFTQGNVARTGGGSGLGLAIVAKIVSQHHGTIRLG 413
Cdd:COG3290 295 EAveklpeEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKI---FERGFSTKLGEGRGLGLALVKQIVEKYGGTIEVE 371
|
170
....*....|....*
gi 914776602 414 DAELGGLLVEIRLPK 428
Cdd:COG3290 372 SEEGEGTVFTVRLPK 386
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-419 |
2.28e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 65.94 E-value: 2.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 327 IRRILNNLSGNSL------RYGATRLQAELKDdGHWVrLRLSDNGPGIPAQDHSRVLKPF-TQGNVartGGGSGLGLAIV 399
Cdd:cd16976 1 IQQVLMNLLQNALdamgkvENPRIRIAARRLG-GRLV-LVVRDNGPGIAEEHLSRVFDPFfTTKPV---GKGTGLGLSIS 75
|
90 100
....*....|....*....|
gi 914776602 400 AKIVSQHHGTIRLGDAELGG 419
Cdd:cd16976 76 YGIVEEHGGRLSVANEEGAG 95
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
323-420 |
6.44e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 64.79 E-value: 6.44e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 323 NPISIRRILNNLSGNSL----RYGATRLQAELKDDGhwVRLRLSDNGPGIPAQDHSRVLKPFTqgNVARTGGG---SGLG 395
Cdd:cd16945 1 DPFLLRQAINNLLDNAIdfspEGGLIALQLEADTEG--IELLVFDEGSGIPDYALNRVFERFY--SLPRPHSGqksTGLG 76
|
90 100
....*....|....*....|....*
gi 914776602 396 LAIVAKIVSQHHGTIRLGDAELGGL 420
Cdd:cd16945 77 LAFVQEVAQLHGGRITLRNRPDGVL 101
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
221-427 |
7.66e-13 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 70.17 E-value: 7.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 221 IE-ERNMMMAGVSHDLRTPLTRIRLATEMMSSGdeylkesinADIDESngIIDQFIDYI------------------RPD 281
Cdd:NF033092 368 IEqERREFVANVSHELRTPLTTMRSYLEALADG---------AWKDPE--LAPRFLGVTqnetermirlvndllqlsRMD 436
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 282 EG---LDTQQIDLTQLIHDAL----LMQTDQGLEVELILPEQAVRVACNPISIRRILNNLSGNSLRY---GATrLQAELK 351
Cdd:NF033092 437 SKdykLNKEWVNFNEFFNYIIdrfeMILKNKNITFKREFPKRDLWVEIDTDKITQVLDNIISNAIKYspeGGT-ITFRLL 515
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 914776602 352 DDGHWVRLRLSDNGPGIPAQDHSRVLKPFTQGNVARTG--GGSGLGLAIVAKIVSQHHGTIRLgDAELG-GLLVEIRLP 427
Cdd:NF033092 516 ETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRkmGGTGLGLAIAKEVVEAHGGRIWA-ESEEGkGTTIYFTLP 593
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
227-427 |
2.59e-12 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 68.94 E-value: 2.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 227 MMAGVSHDLRTPLTRIRLATEMM-------SSGDEYLKESINAdIDESNGIIDQFIDYIRPDEGLdTQQIDLTQLIHDA- 298
Cdd:PRK13837 453 LASGIAHNFNNILGAILGYAEMAlnklarhSRAARYIDEIISA-GARARLIIDQILAFGRKGERN-TKPFDLSELVTEIa 530
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 299 --LLMQTDQGLEVELILPEQAVRVACNPISIRRILNNLSGN-------------SLRYGATRLQAELKDD----GHWVRL 359
Cdd:PRK13837 531 plLRVSLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNaaqamdgagrvdiSLSRAKLRAPKVLSHGvlppGRYVLL 610
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 360 RLSDNGPGIPAQDHSRVLKPF--TQGnvartgGGSGLGLAIVAKIVSQHHGTIRLGDAELGGLLVEIRLP 427
Cdd:PRK13837 611 RVSDTGAGIDEAVLPHIFEPFftTRA------GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
224-427 |
3.24e-12 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 68.61 E-value: 3.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 224 RNMMMAGVSHDLRTPLTRIRLATEMMSSG---DEYLKESIN---ADIDESNGIIDQFIDYIRPDEG---LDTQQIDLTQL 294
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLSGSglsKEQRVEAISlayATGQSLLGLIGEILDVDKIESGnyqLQPQWVDIPTL 791
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 295 IHD------ALLMQTDQGLEVELILPEQAVrVACNPISIRRILNNLSGNSLRY---GATRLQAELK--DDGHWV-RLRLS 362
Cdd:PRK09959 792 VQNtchsfgAIAASKSIALSCSSTFPDHYL-VKIDPQAFKQVLSNLLSNALKFtteGAVKITTSLGhiDDNHAViKMTIM 870
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 914776602 363 DNGPGIPAQDHSRVLKPFTQGNVARTGGGSGLGLAIVAKIVSQHHGTIRLGDAELGGLLVEIRLP 427
Cdd:PRK09959 871 DSGSGLSQEEQQQLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIP 935
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-427 |
5.23e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 61.96 E-value: 5.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 327 IRRILNNLSGNSLRYGATRLQAELK----DDGHWVRLRLSDNGPGIPAQDHSRVLKPFTQGNVARTGGGSGLGLAIVAKI 402
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEvgaeDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYEGTGVGLAIVRKI 80
|
90 100
....*....|....*....|....*
gi 914776602 403 VSQHHGTIRLGDAELGGLLVEIRLP 427
Cdd:cd16921 81 IERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
150-427 |
1.79e-11 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 66.25 E-value: 1.79e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 150 LILYMSVLLVVTLFAAWRFA-RQLVRPLEDLEAGAVAVARGNFP--------DALGEQgSREVRRLTRTFNHMSSSIKRL 220
Cdd:COG4192 328 LLAIALLSLLLAVLINYFYVrRRLVKRLNALSDAMAAIAAGDLDvpipvdgnDEIGRI-ARLLRVFRDQAIEKTQELETE 406
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 221 IEERN--------MM---------------MAGVSHDLRTPLTRI-------RLATEM--MSSGDEYLkESINADIDESN 268
Cdd:COG4192 407 IEERKrieknlrqTQdeliqaakmavvgqtMTSLAHELNQPLNAMsmylfsaKKALEQenYAQLPTSL-DKIEGLIERMD 485
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 269 GIIDQFIDYIRPDEGlDTQQIDLTQLIHDALLMQTDQG--LEVELILPeQAVRVACNPISIRRILNNLSGNSLRYGAT-- 344
Cdd:COG4192 486 KIIKSLRQFSRKSDT-PLQPVDLRQVIEQAWELVESRAkpQQITLHIP-DDLMVQGDQVLLEQVLVNLLVNALDAVATqp 563
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 345 RLQAELKDDGHWVRLRLSDNGPGIPAQDhsRVLKPFTQGNVArtggGSGLGLAIVAKIVSQHHGTIRLGDAELGGLLVEI 424
Cdd:COG4192 564 QISVDLLSNAENLRVAISDNGNGWPLVD--KLFTPFTTTKEV----GLGLGLSICRSIMQQFGGDLYLASTLERGAMVIL 637
|
...
gi 914776602 425 RLP 427
Cdd:COG4192 638 EFN 640
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
224-407 |
2.12e-11 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 65.42 E-value: 2.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 224 RNMMmAGVSHDLRTPLTRIRLATEMMSsgDEYLKESINA--------DIDESNGIIDQFIDYIR----PDEGLDtQQID- 290
Cdd:PRK11006 205 RNFF-ANVSHELRTPLTVLQGYLEMMQ--DQPLEGALREkalhtmreQTQRMEGLVKQLLTLSKieaaPTIDLN-EKVDv 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 291 ---LTQLIHDAL-LMQTDQGLEVELilpEQAVRVACNPISIRRILNNLSGNSLRY--GATRLQAELKDDGHWVRLRLSDN 364
Cdd:PRK11006 281 pmmLRVLEREAQtLSQGKHTITFEV---DNSLKVFGNEDQLRSAISNLVYNAVNHtpEGTHITVRWQRVPQGAEFSVEDN 357
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 914776602 365 GPGIPAQDHSRVLKPFTQGNVART--GGGSGLGLAIVAKIVSQHH 407
Cdd:PRK11006 358 GPGIAPEHIPRLTERFYRVDKARSrqTGGSGLGLAIVKHALSHHD 402
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
344-410 |
2.41e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 60.49 E-value: 2.41e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 914776602 344 TRLQAELKDDGHWVRLRLS----DNGPGIPAQDHSRVLKPFTQGNVartgGGSGLGLAIVAKIVSQHHGTI 410
Cdd:cd16918 27 TRTQRQVTLGHPRHRLALRvsviDNGPGIPPDLQDTIFYPMVSGRE----NGTGLGLAIAQNIVSQHGGVI 93
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
324-427 |
5.22e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 59.36 E-value: 5.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 324 PISIRRILNNLSGNSL----RYGATRLQAELKDDGHWVRLRlsDNGPGIPAQDHSRVLKPF-TQGNVartGGGSGLGLAI 398
Cdd:cd16943 1 PSQLNQVLLNLLVNAAqameGRGRITIRTWAHVDQVLIEVE--DTGSGIDPEILGRIFDPFfTTKPV---GEGTGLGLSL 75
|
90 100
....*....|....*....|....*....
gi 914776602 399 VAKIVSQHHGTIRLGDAELGGLLVEIRLP 427
Cdd:cd16943 76 SYRIIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-427 |
8.28e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 58.70 E-value: 8.28e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 327 IRRILNNLsgnsLRYGATRLQAELKDDGHwVRLRLS------------DNGPGIPAQDHSRVLKPFtqgnVARTGGGSGL 394
Cdd:cd16944 5 ISQVLTNI----LKNAAEAIEGRPSDVGE-VRIRVEadqdgrivlivcDNGKGFPREMRHRATEPY----VTTRPKGTGL 75
|
90 100 110
....*....|....*....|....*....|...
gi 914776602 395 GLAIVAKIVSQHHGTIRLGDAELGGLLVEIRLP 427
Cdd:cd16944 76 GLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
225-412 |
9.04e-11 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 64.10 E-value: 9.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 225 NMmmagvSHDLRTPL------TRIRLATEMMSSGDEYLKEsinadIDES--N--GIIDQFIDYIRPDEG---LDTQQIDL 291
Cdd:PRK11107 299 NM-----SHELRTPLngvigfTRQTLKTPLTPTQRDYLQT-----IERSanNllAIINDILDFSKLEAGklvLENIPFSL 368
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 292 TQLIHDA--LLMQT--DQGLEVELIL----PEQavrVACNPISIRRILNNLSGNSLRY---GATRLQAELKD-DGHWVRL 359
Cdd:PRK11107 369 RETLDEVvtLLAHSahEKGLELTLNIdpdvPDN---VIGDPLRLQQIITNLVGNAIKFtesGNIDILVELRAlSNTKVQL 445
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 914776602 360 R--LSDNGPGIPAQDHSRVLKPFTQGN--VARTGGGSGLGLAIVAKIVSQHHGTIRL 412
Cdd:PRK11107 446 EvqIRDTGIGISERQQSQLFQAFRQADasISRRHGGTGLGLVITQKLVNEMGGDISF 502
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
330-427 |
3.12e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 57.30 E-value: 3.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 330 ILNNLSGNSLRYGA--TRLQAELKDDGHWVRLRLSDNGPGIPAQDHSRVLKPFTQGNVARTGGGS-GLGLAIVAKIVSQH 406
Cdd:cd16948 9 IIGQIVSNALKYSKqgGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQEStGMGLYLVKKLCDKL 88
|
90 100
....*....|....*....|.
gi 914776602 407 HGTIRLGDAELGGLLVEIRLP 427
Cdd:cd16948 89 GHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-425 |
5.62e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 56.32 E-value: 5.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 327 IRRILNNLSGNSLRYGATRLQAEL--KDDGHWVRLRLSDNGPGIPAQDHSRVLKPFTQGNVARTGGG-SGLGLAIVAKIV 403
Cdd:cd16975 5 LSRALINIISNACQYAPEGGTVSIsiYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGhYGMGLYIAKNLV 84
|
90 100
....*....|....*....|..
gi 914776602 404 SQHHGTIRLGDAELGGLLVEIR 425
Cdd:cd16975 85 EKHGGSLIIENSQKGGAEVTVK 106
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
227-410 |
7.34e-10 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 60.35 E-value: 7.34e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 227 MMAGVSHDLRTPLTRIRLATEMMSSGdeylkeSINADIDESNGIIDQFIDYIR-------------------PDEGLDT- 286
Cdd:PRK09303 154 VLAMLAHDLRTPLTAASLALETLELG------QIDEDTELKPALIEQLQDQARrqleeierlitdllevgrtRWEALRFn 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 287 -QQIDLTQLIHDALLMQTDQ----GLEVELILPEQAVRVACNPISIRRILNNLSGNSLRY----GATRLQAeLKDDGHWV 357
Cdd:PRK09303 228 pQKLDLGSLCQEVILELEKRwlakSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKYtpegGTITLSM-LHRTTQKV 306
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 914776602 358 RLRLSDNGPGIPAQDHSRVLkpftQGNV--ARTGG--GSGLGLAIVAKIVSQHHGTI 410
Cdd:PRK09303 307 QVSICDTGPGIPEEEQERIF----EDRVrlPRDEGteGYGIGLSVCRRIVRVHYGQI 359
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
150-431 |
9.81e-10 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 60.69 E-value: 9.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 150 LILYMSVLLVVTLFAAWRFA-RQLVRPLEDLEAGAVAVARGN----FPDALG-----------EQGSREVRRLTRTFNHM 213
Cdd:PRK11466 333 LLLLGMVSLCALILILWRVVyRSVTRPLAEQTQALQRLLDGDidspFPETAGvreldtigrlmDAFRSNVHALNRHREQL 412
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 214 SSSIKR--------LIEER-------------NMMMAGVSHDLRTPLTRIrLATEMMSSGDEYLK------ESINADIDE 266
Cdd:PRK11466 413 AAQVKArtaelqelVIEHRqaraeaekasqakSAFLAAMSHEIRTPLYGI-LGTAQLLADNPALNaqrddlRAITDSGES 491
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 267 SNGIIDQFIDYIRPDEG-----LDTQQIDLTQLIHDAL-LMQTD-QGLEVELI------LPEQavrVACNPISIRRILNN 333
Cdd:PRK11466 492 LLTILNDILDYSAIEAGgknvsVSDEPFEPRPLLESTLqLMSGRvKGRPIRLAtdiaddLPTA---LMGDPRRIRQVITN 568
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 334 LSGNSLRY---GATRLQAELkDDGHWVrLRLSDNGPGIPAQDHSRVLKPFTQGNVARtgGGSGLGLAIVAKIVSQHHGTI 410
Cdd:PRK11466 569 LLSNALRFtdeGSIVLRSRT-DGEQWL-VEVEDSGCGIDPAKLAEIFQPFVQVSGKR--GGTGLGLTISSRLAQAMGGEL 644
|
330 340
....*....|....*....|.
gi 914776602 411 RLGDAELGGLLVEIRLPKHQP 431
Cdd:PRK11466 645 SATSTPEVGSCFCLRLPLRVA 665
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-410 |
1.04e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 55.47 E-value: 1.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 328 RRILNNLSGNSLRYGA--TRLQAELKDDGHWVRLRLSDNGPGIPAQDHSRVLKPFTQGNVARTGGGSGLGLAIVAKIVSQ 405
Cdd:cd16923 2 QRVFSNLLSNAIKYSPenTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGAGLGLSIAKAIIEL 81
|
....*
gi 914776602 406 HHGTI 410
Cdd:cd16923 82 HGGSA 86
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
226-427 |
1.47e-09 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 60.37 E-value: 1.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 226 MMMAGVSHDLRTPLTRI-----------------RLATEMMSSGDEYLKesinadidesngIIDQFIDY---------IR 279
Cdd:PRK10841 449 MFLATVSHELRTPLYGIignldllqtkelpkgvdRLVTAMNNSSSLLLK------------IISDILDFskieseqlkIE 516
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 280 PDEgLDTQQIdLTQLIHDALLMQTDQGLEVE-LILPEQAVRVACNPISIRRILNNLSGNSLRY---GATRLQAELKDDGH 355
Cdd:PRK10841 517 PRE-FSPREV-INHITANYLPLVVKKRLGLYcFIEPDVPVALNGDPMRLQQVISNLLSNAIKFtdtGCIVLHVRVDGDYL 594
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 914776602 356 WVRLRlsDNGPGIPAQDHSRVLKPFTQ--GNVARTGGGSGLGLAIVAKIVSQHHGTIRLgDAELG-GLLVEIRLP 427
Cdd:PRK10841 595 SFRVR--DTGVGIPAKEVVRLFDPFFQvgTGVQRNFQGTGLGLAICEKLINMMDGDISV-DSEPGmGSQFTIRIP 666
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
150-431 |
3.21e-09 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 57.32 E-value: 3.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 150 LILYMSVLLVVTLFAAWRFARQLVRPLEDLEAGAVAVARgnfpdalgeqgSREVRRLTR----TFNHMSSSIKRLIEERN 225
Cdd:COG4585 12 LLVGALLGLLLALVLLRARRAERAAELERELAARAEEAR-----------EEERRRIARelhdGVGQSLSAIKLQLEAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 226 MMMAGVSHDLRTPLTRIRlatemmssgdeylkESINADIDESNGIIDQFIDYIRPDEGLDTqqiDLTQLIHDallMQTDQ 305
Cdd:COG4585 81 RLLDADPEAAREELEEIR--------------ELAREALAELRRLVRGLRPPALDDLGLAA---ALEELAER---LLRAA 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 306 GLEVELILPEQAVRVacnPISIR----RILNNLSGNSLRY-GATRLQAELKDDGHWVRLRLSDNGPGIPAQdhsrvlkpf 380
Cdd:COG4585 141 GIRVELDVDGDPDRL---PPEVElalyRIVQEALTNALKHaGATRVTVTLEVDDGELTLTVRDDGVGFDPE--------- 208
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 914776602 381 tqgnvarTGGGSGLGLAIVAKIVSQHHGTIRLGDAELGGLLVEIRLPKHQP 431
Cdd:COG4585 209 -------AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
223-283 |
4.68e-09 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 52.57 E-value: 4.68e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 914776602 223 ERNMMMAGVSHDLRTPLTRIRLATEMMSSGD------EYLkESINADIDESNGIIDQFIDYIRPDEG 283
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTElseeqrEYL-ETILREAERLLRLINDLLDLSRIEAG 66
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
151-431 |
7.47e-09 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 57.72 E-value: 7.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 151 ILYMSVLLVVTLFaaWRFARQLVRPLEDLEAGAVAVARGNfPDALGEQGSREVRRLTRTFNHMSSSIKRLIEERNMMMAG 230
Cdd:PRK10815 196 VLLANLLLVIPLL--WLAAWWSLRPIEALAKQVRELEEGE-REQLDPNPPRELTSLVRNLNRLLKNERERYTKYRTTLTD 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 231 VSHDLRTPLTRirLATEMMSsgdeyLKESINADIDESNGI-------IDQFIDY------IRPDEGLDTQQIDLTQLIHD 297
Cdd:PRK10815 273 LTHSLKTPLAV--LQSTLRS-----LRSGKQMSVEQAEPImleqisrISQQIGYylhrasMRSEHNLLSRELHSVAPLLD 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 298 AL---LMQTDQ--GLEVEL-ILPEQAVRVACNpiSIRRILNNLSGNSLRYGATRLQAELKDDGHWVRLRLSDNGPGIPAQ 371
Cdd:PRK10815 346 NLtsaLNKVYQrkGVNITLdISPEITFVGEKN--DFMEVMGNVLDNACKYCLEFVEISARQTDEHLHIVVEDDGPGIPES 423
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 914776602 372 DHSRVlkpFTQGNVART-GGGSGLGLAIVAKIVSQHHGTIRLGDAELGGLLVEIRLPKHQP 431
Cdd:PRK10815 424 KRELI---FDRGQRADTlRPGQGLGLSVAREITEQYEGKISAGDSPLGGARMEVIFGRQHS 481
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
223-283 |
1.00e-08 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 51.44 E-value: 1.00e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 914776602 223 ERNMMMAGVSHDLRTPLTRIRLATEMMSSGD------EYLkESINADIDESNGIIDQFIDYIRPDEG 283
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKldeeqrEYL-ETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HAMP |
pfam00672 |
HAMP domain; |
167-219 |
2.03e-08 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 50.32 E-value: 2.03e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 914776602 167 RFARQLVRPLEDLEAGAVAVARGNFPDALGEQGSREVRRLTRTFNHMSSSIKR 219
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
231-410 |
2.48e-08 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 56.10 E-value: 2.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 231 VSHDLRTP------LTRIRLATEMMSSGDEYLKeSINA------DIdeSNGIIDqfIDYI-RPDEGLDTQQIDLTQLIHD 297
Cdd:PRK11091 290 ISHELRTPlngivgLSRILLDTELTAEQRKYLK-TIHVsaitlgNI--FNDIID--MDKMeRRKLQLDNQPIDFTDFLAD 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 298 ----ALLMQTDQGL----EVELILPEQavrVACNPISIRRILNNLSGNSLRY----GAT-RLQAELKDDghwVRLRLSDN 364
Cdd:PRK11091 365 lenlSGLQAEQKGLrfdlEPLLPLPHK---VITDGTRLRQILWNLISNAVKFtqqgGVTvRVRYEEGDM---LTFEVEDS 438
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 914776602 365 GPGIPAQDHSRVLKPFTQ-----GNVARTggGSGLGLAIVAKIVSQHHGTI 410
Cdd:PRK11091 439 GIGIPEDELDKIFAMYYQvkdshGGKPAT--GTGIGLAVSKRLAQAMGGDI 487
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
354-427 |
3.01e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 51.61 E-value: 3.01e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 914776602 354 GHWVRLRLSDNGPGIPAQDHSRVLKPF--TQGnvarTGGGSGLGLAIVAKIVSQHHGTIRLgDAELG-GLLVEIRLP 427
Cdd:cd16919 45 GNYVCLEVSDTGSGMPAEVLRRAFEPFftTKE----VGKGTGLGLSMVYGFVKQSGGHLRI-YSEPGvGTTVRIYLP 116
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
150-321 |
3.32e-08 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 55.66 E-value: 3.32e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 150 LILYMSVLLVVTLFAAWRFARQLVRPLEDLEAGAVAVARGNFPDALGEQGSREVRRLTRTFNHMSSSIKRLIEERNMMMA 229
Cdd:COG3850 120 ALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELYAELEEEEE 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 230 GVSHDLRTPLTRIRLATEMMSSGDEYLKESINADIDESNGIIDQFIDYIRPDEGLDTQQIDLTQLIHDALLMQTDQGLEV 309
Cdd:COG3850 200 LEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASALL 279
|
170
....*....|..
gi 914776602 310 ELILPEQAVRVA 321
Cdd:COG3850 280 LLELELLALLLE 291
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
282-430 |
3.87e-08 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 55.30 E-value: 3.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 282 EGLDTQQIDLTQLIHDAL--LMQTDQGLEVELIL--------PEQAVrvacnPISIrrILNNLSGNSLRYGAT-----RL 346
Cdd:COG3920 352 QSEDWEGVDLRDYLRELLepLRDSYGGRGIRIELdgpdvelpADAAV-----PLGL--ILNELVTNALKHAFLsgeggRI 424
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 347 QAELKDDGHWVRLRLSDNGPGIPAQdhsrvlkpftqgnvARTGGGSGLGLAIVAKIVSQHHGTIRLGDAElgGLLVEIRL 426
Cdd:COG3920 425 RVSWRREDGRLRLTVSDNGVGLPED--------------VDPPARKGLGLRLIRALVRQLGGTLELDRPE--GTRVRITF 488
|
....
gi 914776602 427 PKHQ 430
Cdd:COG3920 489 PLAE 492
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
221-279 |
8.17e-08 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 48.75 E-value: 8.17e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 914776602 221 IEERNMMMAGVSHDLRTPLTRIRLATEMMSSG-------DEYLkESINADIDESNGIIDQFIDYIR 279
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEEllddeeqREYL-ERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-406 |
1.28e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 49.51 E-value: 1.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 327 IRRILNNLSGNSLRYG--ATRLQAELKDDGHWVRLRLSDNGPGIPAQDHSRVLKPFTQGNVARTG--GGSGLGLAIVAKI 402
Cdd:cd16952 1 LRSAFSNLVSNAVKYTppSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRntGGTGLGLAIVKHV 80
|
....
gi 914776602 403 VSQH 406
Cdd:cd16952 81 MSRH 84
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
170-222 |
1.46e-07 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 48.01 E-value: 1.46e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 914776602 170 RQLVRPLEDLEAGAVAVARGNFPDALGEQGSREVRRLTRTFNHMSSSIKRLIE 222
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
308-412 |
1.97e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 49.43 E-value: 1.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 308 EVELILPEQAVRVACNPISIRRILNNLSGNSLRYGATR--LQAELKDDGHWVRLRLSDNGPGIPAQDHSRVL-KPFT-QG 383
Cdd:cd16947 2 QVEINIPDRPIYANANTEALQRILKNLISNAIKYGSDGkfLGMTLREDEKHVYIDIWDKGKGISETEKDHVFeRLYTlED 81
|
90 100
....*....|....*....|....*....
gi 914776602 384 NVARTGGGSGLGLAIVAKIVSQHHGTIRL 412
Cdd:cd16947 82 SRNSAKQGNGLGLTITKRLAESMGGSIYV 110
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
353-427 |
2.05e-07 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 53.14 E-value: 2.05e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 914776602 353 DGHWVRLRLSDNGPGIPAQDHSRVLKPF--TQGNvartGGGSGLGLAIVAKIVSQHHGTIRLGDAELGGLLVEIRLP 427
Cdd:PRK13557 321 PGRYVSIAVTDTGSGMPPEILARVMDPFftTKEE----GKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFP 393
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
56-426 |
7.05e-07 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 51.65 E-value: 7.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 56 IDSKQLALSEDAEALVYVATGSDIYTQSEAEQHGLNESKPYTYLEESISHELKGQTKVRVEIQDHYIIWIQPPQANQMWV 135
Cdd:COG2770 120 LLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLL 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 136 RIPLTEIEDDDIEPLILYMSVLLVVTLFAAWRFARQLVRPLEDLEAGAVAVARGNFPDALGEQGSREVRRLTRTFNHMSS 215
Cdd:COG2770 200 LVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMAD 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 216 SIKRLIEERNMMMAGVSHDLRTPLTRIRLATEMMSSGDEYLKESINADIDESNGIIDQFIDYIRPDEGLDTQQIDLTQLI 295
Cdd:COG2770 280 SLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAAL 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 296 HDALLMQTDQGLEVELILPEQAVRVACNPISIRRILNNLSGNSLRYGATRLQAELKDDGHWVRLRLSDNGPGIPAQDHSR 375
Cdd:COG2770 360 LLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALE 439
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 914776602 376 VLKPFTQGNVARTGGGSGLGLAIVAKIVSQHHGTIRLGDAELGGLLVEIRL 426
Cdd:COG2770 440 LAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELL 490
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
173-217 |
1.16e-06 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 45.13 E-value: 1.16e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 914776602 173 VRPLEDLEAGAVAVARGNFPDALGEQGSREVRRLTRTFNHMSSSI 217
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-427 |
1.35e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 46.62 E-value: 1.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 327 IRRILNNLSGNSLR----YGATR----LQAELKDDGHwVRLRLSDNGPGIPAQDHSRVLKPFTQGNVArtggGSGLGLAI 398
Cdd:cd16920 1 IQQVLINLVRNGIEamseGGCERreltIRTSPADDRA-VTISVKDTGPGIAEEVAGQLFDPFYTTKSE----GLGMGLSI 75
|
90 100
....*....|....*....|....*....
gi 914776602 399 VAKIVSQHHGTIRLGDAELGGLLVEIRLP 427
Cdd:cd16920 76 CRSIIEAHGGRLSVESPAGGGATFQFTLP 104
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|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
329-410 |
3.45e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 45.64 E-value: 3.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 329 RILNNLSGNSLRY---GATRLQAELKDDGHWVRLRLSDNGPGIPAQDHSRVLKPFTQGNVART--GGGSGLGLAIVAKIV 403
Cdd:cd16953 3 QVLRNLIGNAISFsppDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEafGQHSGLGLSISRQII 82
|
....*..
gi 914776602 404 SQHHGTI 410
Cdd:cd16953 83 EAHGGIS 89
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|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-427 |
4.79e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 44.47 E-value: 4.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 337 NSLRY-GATRLQAELKDDGHWVRLRLSDNGPGIPAQDHSrvlkpftqgnvartgGGSGLGLAIVAKIVSQHHGTIRLGDA 415
Cdd:cd16917 11 NALKHaGASRVRVTLSYTADELTLTVVDDGVGFDGPAPP---------------GGGGFGLLGMRERAELLGGTLTIGSR 75
|
90
....*....|..
gi 914776602 416 ELGGLLVEIRLP 427
Cdd:cd16917 76 PGGGTRVTARLP 87
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|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
151-220 |
8.96e-06 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 47.93 E-value: 8.96e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 914776602 151 ILYMSVLLVVTLFAAWRFARQLVRPLEDLEAGAVAVARGNF-PDALGEQGSREVRRLTRTFNHMSSSIKRL 220
Cdd:PRK10935 155 LLGLILILTLVFFTVRFTRRQVVAPLNQLVTASQQIEKGQFdHIPLDTTLPNELGLLAKAFNQMSSELHKL 225
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|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
358-410 |
1.19e-05 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 47.00 E-value: 1.19e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 914776602 358 RLRLSDNGPGIPAQDHSRVLKPFTQGNvartGGGSGLGLAIVAKIVSQHHGTI 410
Cdd:PRK11073 282 RIDIEDNGPGIPPHLQDTLFYPMVSGR----EGGTGLGLSIARNLIDQHSGKI 330
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|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
141-223 |
2.26e-05 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 46.55 E-value: 2.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 141 EIEDDDIEPLILYMSVLLVVTLFAAWRFARQLVRPLEDLEAGAVAVARGNFPDALGEQGSREVRRLTRTFNHMSSSIKRL 220
Cdd:COG0840 175 AAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLREL 254
|
...
gi 914776602 221 IEE 223
Cdd:COG0840 255 VGQ 257
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
330-431 |
4.32e-04 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 42.51 E-value: 4.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914776602 330 ILNNLSGN----SLRY--GATRLQAELKDDGHWVRLRLSDNGPGIPAQDHSRVlkpFTQGNVARTG--GGSGLGLAIVAK 401
Cdd:PRK15053 436 IVGNLLDNafeaSLRSdeGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKI---FEQGVSTRADepGEHGIGLYLIAS 512
|
90 100 110
....*....|....*....|....*....|
gi 914776602 402 IVSQHHGTIRLGDAELGGLLVEIRLPKHQP 431
Cdd:PRK15053 513 YVTRCGGVITLEDNDPCGTLFSIFIPKVKP 542
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|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
337-403 |
1.21e-03 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 38.02 E-value: 1.21e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 914776602 337 NSLRYG-----ATRLQAELKDDGHWVRLRLSDNGPGIPaqdhsrVLKPFTQGNVARTGggsGLGLAIVAKIV 403
Cdd:cd16936 11 NAVRHAyrhdgPGPVRLELDLDPDRLRVEVTDSGPGFD------PLRPADPDAGLREG---GRGLALIRALM 73
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
337-405 |
2.13e-03 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 37.97 E-value: 2.13e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 914776602 337 NSLRYG-----ATRLQAELKDDGHWVRLRLSDNGPGIPAQDhsrVLKPFTqgnvarTGGGSGLGLAIVAKIVSQ 405
Cdd:COG2172 45 NAVRHAyggdpDGPVEVELELDPDGLEIEVRDEGPGFDPED---LPDPYS------TLAEGGRGLFLIRRLMDE 109
|
|
| mutl |
TIGR00585 |
DNA mismatch repair protein MutL; All proteins in this family for which the functions are ... |
313-381 |
2.35e-03 |
|
DNA mismatch repair protein MutL; All proteins in this family for which the functions are known are involved in the process of generalized mismatch repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273155 [Multi-domain] Cd Length: 312 Bit Score: 39.93 E-value: 2.35e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 914776602 313 LPEQAVRVACNPISIRR---ILNNLSGNSLRYGATRLQAELKDDGhWVRLRLSDNGPGIPAQDHSRVLKPFT 381
Cdd:TIGR00585 6 LPPELVNKIAAGEVIERpasVVKELVENSLDAGATRIDVEIEEGG-LKLIEVSDNGSGIDKEDLPLACERHA 76
|
|
| HATPase_RsbT-like |
cd16934 |
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ... |
334-404 |
4.27e-03 |
|
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.
Pssm-ID: 340411 [Multi-domain] Cd Length: 117 Bit Score: 36.96 E-value: 4.27e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 914776602 334 LSGNSLRY---GATRLQAELKDDGHWVRLRLSDNGPGIPAQDHSRvlkpftqGNVARTGGGSGLGLAIVAKIVS 404
Cdd:cd16934 33 LARNLLKHaggGQVLLEVVAEGGRVALEILAVDQGPGIADVDEAL-------RDGFSTGGGLGLGLGGVRRLAD 99
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