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Conserved domains on  [gi|918073597|ref|WP_052328773|]
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glycosyltransferase family 2 protein [Porphyromonas catoniae]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 11421525)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  16037492|18518825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 10-217 1.24e-39

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 138.68  E-value: 1.24e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  10 PLLTFIVPVYNVAPWLDECISSILRAGVSELELLLVDDGSTDGSGAMCDAWQVREPHIRVI-HQPNAGQSVARNVALSEA 88
Cdd:COG0463    2 PLVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIrLERNRGKGAARNAGLAAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  89 KGKYFTFVDADDWLAPEILGRGLAYMQAHPEVGVleFGYAEVRGLEeevfpILGQEETNNAEKVLELFARMKGPigMPWA 168
Cdd:COG0463   82 RGDYIAFLDADDQLDPEKLEELVAALEEGPADLV--YGSRLIREGE-----SDLRRLGSRLFNLVRLLTNLPDS--TSGF 152

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 918073597 169 KIFRTELAGDLRFPEgRIYEDTPFVfsALTRSGYyhYMAEVGYYYRIGR 217
Cdd:COG0463  153 RLFRREVLEELGFDE-GFLEDTELL--RALRHGF--RIAEVPVRYRAGE 196
 
Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 10-217 1.24e-39

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 138.68  E-value: 1.24e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  10 PLLTFIVPVYNVAPWLDECISSILRAGVSELELLLVDDGSTDGSGAMCDAWQVREPHIRVI-HQPNAGQSVARNVALSEA 88
Cdd:COG0463    2 PLVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIrLERNRGKGAARNAGLAAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  89 KGKYFTFVDADDWLAPEILGRGLAYMQAHPEVGVleFGYAEVRGLEeevfpILGQEETNNAEKVLELFARMKGPigMPWA 168
Cdd:COG0463   82 RGDYIAFLDADDQLDPEKLEELVAALEEGPADLV--YGSRLIREGE-----SDLRRLGSRLFNLVRLLTNLPDS--TSGF 152

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 918073597 169 KIFRTELAGDLRFPEgRIYEDTPFVfsALTRSGYyhYMAEVGYYYRIGR 217
Cdd:COG0463  153 RLFRREVLEELGFDE-GFLEDTELL--RALRHGF--RIAEVPVRYRAGE 196
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 13-123 1.33e-33

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 121.35  E-value: 1.33e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597   13 TFIVPVYNVAPWLDECISSILRAGVSELELLLVDDGSTDGSGAMCDAWQVREPHIRVIHQP-NAGQSVARNVALSEAKGK 91
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYPNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPeNRGKAGARNAGLRAATGD 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 918073597   92 YFTFVDADDWLAPEILGRGLAYMQAHPEVGVL 123
Cdd:pfam00535  81 YIAFLDADDEVPPDWLEKLVEALEEDGADVVV 112
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 9-105 3.01e-33

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 125.16  E-value: 3.01e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597   9 EPLLTFIVPVYNVAPWLDECISSILRAGVSELELLLVDDGSTDGSGAMCDAWQVREPHIRVIHQPNAGQSVARNVALSEA 88
Cdd:PRK10073   5 TPKLSIIIPLYNAGKDFRAFMESLIAQTWTALEIIIVNDGSTDNSVEIAKHYAENYPHVRLLHQANAGVSVARNTGLAVA 84

                         90
                 ....*....|....*..
gi 918073597  89 KGKYFTFVDADDWLAPE 105
Cdd:PRK10073  85 TGKYVAFPDADDVVYPT 101
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 15-122 2.57e-32

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 117.61  E-value: 2.57e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  15 IVPVYNVAPWLDECISSILRAGVSELELLLVDDGSTDGSGAMCDAWQVREPH-IRVIHQPNAGQSVARNVALSEAKGKYF 93
Cdd:cd00761    2 IIPAYNEEPYLERCLESLLAQTYPNFEVIVVDDGSTDGTLEILEEYAKKDPRvIRVINEENQGLAAARNAGLKAARGEYI 81

                         90       100
                 ....*....|....*....|....*....
gi 918073597  94 TFVDADDWLAPEILGRGLAYMQAHPEVGV 122
Cdd:cd00761   82 LFLDADDLLLPDWLERLVAELLADPEADA 110
 
Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 10-217 1.24e-39

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 138.68  E-value: 1.24e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  10 PLLTFIVPVYNVAPWLDECISSILRAGVSELELLLVDDGSTDGSGAMCDAWQVREPHIRVI-HQPNAGQSVARNVALSEA 88
Cdd:COG0463    2 PLVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIrLERNRGKGAARNAGLAAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  89 KGKYFTFVDADDWLAPEILGRGLAYMQAHPEVGVleFGYAEVRGLEeevfpILGQEETNNAEKVLELFARMKGPigMPWA 168
Cdd:COG0463   82 RGDYIAFLDADDQLDPEKLEELVAALEEGPADLV--YGSRLIREGE-----SDLRRLGSRLFNLVRLLTNLPDS--TSGF 152

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 918073597 169 KIFRTELAGDLRFPEgRIYEDTPFVfsALTRSGYyhYMAEVGYYYRIGR 217
Cdd:COG0463  153 RLFRREVLEELGFDE-GFLEDTELL--RALRHGF--RIAEVPVRYRAGE 196
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 13-123 1.33e-33

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 121.35  E-value: 1.33e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597   13 TFIVPVYNVAPWLDECISSILRAGVSELELLLVDDGSTDGSGAMCDAWQVREPHIRVIHQP-NAGQSVARNVALSEAKGK 91
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYPNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPeNRGKAGARNAGLRAATGD 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 918073597   92 YFTFVDADDWLAPEILGRGLAYMQAHPEVGVL 123
Cdd:pfam00535  81 YIAFLDADDEVPPDWLEKLVEALEEDGADVVV 112
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 9-105 3.01e-33

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 125.16  E-value: 3.01e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597   9 EPLLTFIVPVYNVAPWLDECISSILRAGVSELELLLVDDGSTDGSGAMCDAWQVREPHIRVIHQPNAGQSVARNVALSEA 88
Cdd:PRK10073   5 TPKLSIIIPLYNAGKDFRAFMESLIAQTWTALEIIIVNDGSTDNSVEIAKHYAENYPHVRLLHQANAGVSVARNTGLAVA 84

                         90
                 ....*....|....*..
gi 918073597  89 KGKYFTFVDADDWLAPE 105
Cdd:PRK10073  85 TGKYVAFPDADDVVYPT 101
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 15-122 2.57e-32

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 117.61  E-value: 2.57e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  15 IVPVYNVAPWLDECISSILRAGVSELELLLVDDGSTDGSGAMCDAWQVREPH-IRVIHQPNAGQSVARNVALSEAKGKYF 93
Cdd:cd00761    2 IIPAYNEEPYLERCLESLLAQTYPNFEVIVVDDGSTDGTLEILEEYAKKDPRvIRVINEENQGLAAARNAGLKAARGEYI 81

                         90       100
                 ....*....|....*....|....*....
gi 918073597  94 TFVDADDWLAPEILGRGLAYMQAHPEVGV 122
Cdd:cd00761   82 LFLDADDLLLPDWLERLVAELLADPEADA 110
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 7-122 4.84e-24

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 99.43  E-value: 4.84e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597   7 PYEPLLTFIVPVYNVAPWLDECISSILRA--GVSELELLLVDDGSTDGSGAMCDAWQVREPHIRVIHQP-NAGQSVARNV 83
Cdd:COG1215   26 ADLPRVSVIIPAYNEEAVIEETLRSLLAQdyPKEKLEVIVVDDGSTDETAEIARELAAEYPRVRVIERPeNGGKAAALNA 105

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 918073597  84 ALSEAKGKYFTFVDADDWLAPEILGRGLAYMQaHPEVGV 122
Cdd:COG1215  106 GLKAARGDIVVFLDADTVLDPDWLRRLVAAFA-DPGVGA 143
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
9-113 1.14e-22

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 93.52  E-value: 1.14e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597   9 EPLLTFIVPVYNVAPWLDECISSILRAGVSELELLLVDDGSTDGSGAMCDAWQVrePHIRVIHQP-NAGQSVARNVALSE 87
Cdd:COG1216    2 RPKVSVVIPTYNRPELLRRCLESLLAQTYPPFEVIVVDNGSTDGTAELLAALAF--PRVRVIRNPeNLGFAAARNLGLRA 79

                         90       100
                 ....*....|....*....|....*.
gi 918073597  88 AKGKYFTFVDADDWLAPEILGRGLAY 113
Cdd:COG1216   80 AGGDYLLFLDDDTVVEPDWLERLLAA 105
GT2_RfbC_Mx_like cd04184
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene ...
 10-123 5.27e-20

Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133027 [Multi-domain]  Cd Length: 202  Bit Score: 86.10  E-value: 5.27e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  10 PLLTFIVPVYNVAP-WLDECISSILRAGVSELELLLVDDGSTDGS-GAMCDAWQVREPHIRVIHQP-NAGQSVARNVALS 86
Cdd:cd04184    1 PLISIVMPVYNTPEkYLREAIESVRAQTYPNWELCIADDASTDPEvKRVLKKYAAQDPRIKVVFREeNGGISAATNSALE 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 918073597  87 EAKGKYFTFVDADDWLAPEILGRGLAYMQAHPEVGVL 123
Cdd:cd04184   81 LATGEFVALLDHDDELAPHALYEVVKALNEHPDADLI 117
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 15-139 1.91e-18

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 81.07  E-value: 1.91e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  15 IVPVYNVAPWLDECISSILRAGVSELELLLVDDGSTDGSgamCDAWQVREPHIRVIHQP-NAGQSVARNVALSEAKGKYF 93
Cdd:cd04186    2 IIVNYNSLEYLKACLDSLLAQTYPDFEVIVVDNASTDGS---VELLRELFPEVRLIRNGeNLGFGAGNNQGIREAKGDYV 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 918073597  94 TFVDADDWLAPEILGRGLAYMQAHPEVGVLEF---G---------YAEVRGLEEEVFP 139
Cdd:cd04186   79 LLLNPDTVVEPGALLELLDAAEQDPDVGIVGPkvsGafllvrrevFEEVGGFDEDFFL 136
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 15-121 2.92e-18

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 80.73  E-value: 2.92e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  15 IVPVYNVAPWLDECISSILRAGVSELELLLVDDGSTDGSGAMCDAWQVRE--PHIRVIHQPNAGQSVARNVALSEAKGKY 92
Cdd:cd06423    2 IVPAYNEEAVIERTIESLLALDYPKLEVIVVDDGSTDDTLEILEELAALYirRVLVVRDKENGGKAGALNAGLRHAKGDI 81

                         90       100
                 ....*....|....*....|....*....
gi 918073597  93 FTFVDADDWLAPEILGRGLAYMQAHPEVG 121
Cdd:cd06423   82 VVVLDADTILEPDALKRLVVPFFADPKVG 110
beta3GnTL1_like cd06913
Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of ...
 15-105 2.20e-16

Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine ; This family includes human Beta3GnTL1 and related eukaryotic proteins. Human Beta3GnTL1 is a putative beta-1,3-N-acetylglucosaminyltransferase. Beta3GnTL1 is expressed at various levels in most of tissues examined. Beta 1, 3-N-acetylglucosaminyltransferase has been found to be essential for the formation of poly-N-acetyllactosamine. Poly-N-acetyllactosamine is a unique carbohydrate composed of N-acetyllactosamine repeats. It is often an important part of cell-type-specific oligosaccharide structures and some functional oligosaccharides. It has been shown that the structure and biosynthesis of poly-N-acetyllactosamine display a dramatic change during development and oncogenesis. Several members of beta-1, 3-N-acetylglucosaminyltransferase have been identified.


Pssm-ID: 133063 [Multi-domain]  Cd Length: 219  Bit Score: 76.73  E-value: 2.20e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  15 IVPVYNVAPWLDECISSILRAGVS-ELELLLVDDGSTDGSGAMCDAWQVREPHIR---VIHQPNAGQSV----ARNVALS 86
Cdd:cd06913    2 ILPVHNGEQWLDECLESVLQQDFEgTLELSVFNDASTDKSAEIIEKWRKKLEDSGvivLVGSHNSPSPKgvgyAKNQAIA 81

                         90
                 ....*....|....*....
gi 918073597  87 EAKGKYFTFVDADDWLAPE 105
Cdd:cd06913   82 QSSGRYLCFLDSDDVMMPQ 100
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 15-131 2.50e-16

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 76.04  E-value: 2.50e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  15 IVPVYNVAPWLDECISSILRAGVSELELLLVDDGSTDGSGAMCDAWQVRepHIRVIHQPNAGQSVARNVALSEAKGKYFT 94
Cdd:cd06433    3 ITPTYNQAETLEETIDSVLSQTYPNIEYIVIDGGSTDGTVDIIKKYEDK--ITYWISEPDKGIYDAMNKGIALATGDIIG 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 918073597  95 FVDADDWLAPEILGRGLAYMQAHPEVGVLefgYAEVR 131
Cdd:cd06433   81 FLNSDDTLLPGALLAVVAAFAEHPEVDVV---YGDVL 114
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 13-103 2.17e-15

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 74.58  E-value: 2.17e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  13 TFIVPVYNVAPWLDECISSILRAGVSE--LELLLVDDGSTDGSGAMCDAWQVREPHIRVIHQPNAGQSVARNVALSEAKG 90
Cdd:cd02525    3 SIIIPVRNEEKYIEELLESLLNQSYPKdlIEIIVVDGGSTDGTREIVQEYAAKDPRIRLIDNPKRIQSAGLNIGIRNSRG 82

                         90
                 ....*....|....*...
gi 918073597  91 KYFTFVDA-----DDWLA 103
Cdd:cd02525   83 DIIIRVDAhavypKDYIL 100
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 15-99 8.96e-15

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 71.45  E-value: 8.96e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  15 IVPVYNVAPWLDECISSILRAGVS--ELELLLVDDGSTDGSGAMCDAWQVREPHIRVI-HQPNAGQSVARNVALSEAKGK 91
Cdd:cd04179    2 VIPAYNEEENIPELVERLLAVLEEgyDYEIIVVDDGSTDGTAEIARELAARVPRVRVIrLSRNFGKGAAVRAGFKAARGD 81


                 ....*...
gi 918073597  92 YFTFVDAD 99
Cdd:cd04179   82 IVVTMDAD 89
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 15-123 4.54e-13

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 67.27  E-value: 4.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  15 IVPVYNVAPWLDECISSILRAGVSELELLLVDDGSTDGSGAMCDAWQVREPHIRVIHQPNAGQSVARNV--ALSEAKGKY 92
Cdd:cd04196    3 LMATYNGEKYLREQLDSILAQTYKNDELIISDDGSTDGTVEIIKEYIDKDPFIIILIRNGKNLGVARNFesLLQAADGDY 82

                         90       100       110
                 ....*....|....*....|....*....|..
gi 918073597  93 FTFVDADD-WLaPEILGRGLAYMQAHPEVGVL 123
Cdd:cd04196   83 VFFCDQDDiWL-PDKLERLLKAFLKDDKPLLV 113
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 14-99 2.64e-12

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 64.42  E-value: 2.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  14 FIVPVYNVAPWLDEC---ISSILRAGVSELELLLVDDGSTDGSGAMCDAWQVREPHIRVIH-QPNAGQSVARNVALSEAK 89
Cdd:cd04187    1 IVVPVYNEEENLPELyerLKAVLESLGYDYEIIFVDDGSTDRTLEILRELAARDPRVKVIRlSRNFGQQAALLAGLDHAR 80

                         90
                 ....*....|
gi 918073597  90 GKYFTFVDAD 99
Cdd:cd04187   81 GDAVITMDAD 90
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 10-123 1.51e-11

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 63.16  E-value: 1.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597   10 PLLTFIVPVYNVAPWLDECISSILRAGVSELELLLVDDGSTDGSGAMCDAWQVREPH--IRVIHQPNA----GQSVARNV 83
Cdd:pfam13641   2 PDVSVVVPAFNEDSVLGRVLEAILAQPYPPVEVVVVVNPSDAETLDVAEEIAARFPDvrLRVIRNARLlgptGKSRGLNH 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 918073597   84 ALSEAKGKYFTFVDADDWLAPEILGRGLAYMQaHPEVGVL 123
Cdd:pfam13641  82 GFRAVKSDLVVLHDDDSVLHPGTLKKYVQYFD-SPKVGAV 120
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 8-122 2.54e-10

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 59.90  E-value: 2.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597   8 YEPLLTFIVPVYNVAPWLDECISSI--LRAGVSELELLLVDDGSTDGSGAMcdAWQVREPHIRVIHQP-NAGQSVARNVA 84
Cdd:cd06439   27 YLPTVTIIIPAYNEEAVIEAKLENLlaLDYPRDRLEIIVVSDGSTDGTAEI--AREYADKGVKLLRFPeRRGKAAALNRA 104

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 918073597  85 LSEAKGKYFTFVDADDWLAPEILgRGLAYMQAHPEVGV 122
Cdd:cd06439  105 LALATGEIVVFTDANALLDPDAL-RLLVRHFADPSVGA 141
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 12-105 4.73e-10

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 58.84  E-value: 4.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  12 LTFIVPVYNVAPWLDECISSIlrAGVSElELLLVDDGSTDGSGAMCdawqvREPHIRVIHQPNAGQSVARNVALSEAKGK 91
Cdd:cd02511    2 LSVVIITKNEERNIERCLESV--KWAVD-EIIVVDSGSTDRTVEIA-----KEYGAKVYQRWWDGFGAQRNFALELATND 73

                         90
                 ....*....|....
gi 918073597  92 YFTFVDADDWLAPE 105
Cdd:cd02511   74 WVLSLDADERLTPE 87
GT2_Chondriotin_Pol_N cd06420
N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin ...
 14-99 2.95e-09

N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix.


Pssm-ID: 133042 [Multi-domain]  Cd Length: 182  Bit Score: 55.66  E-value: 2.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  14 FIVPVYNVAPWLDECISSILRAGVSELELLLVDDGSTDGSGAMCDAWQVREPhIRVIH--QPNAG--QSVARNVALSEAK 89
Cdd:cd06420    1 LIITTYNRPEALELVLKSVLNQSILPFEVIIADDGSTEETKELIEEFKSQFP-IPIKHvwQEDEGfrKAKIRNKAIAAAK 79

                         90
                 ....*....|
gi 918073597  90 GKYFTFVDAD 99
Cdd:cd06420   80 GDYLIFIDGD 89
PRK10018 PRK10018
colanic acid biosynthesis glycosyltransferase WcaA;
10-115 3.73e-09

colanic acid biosynthesis glycosyltransferase WcaA;


Pssm-ID: 182197 [Multi-domain]  Cd Length: 279  Bit Score: 56.92  E-value: 3.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  10 PLLTFIVPVYNVAPWLDECISSILRAGVSELELLLVDDGSTDGSGAMCDAWQVREPHIRVIHQP-NAGQSVARNVALSEA 88
Cdd:PRK10018   5 PLISIYMPTWNRQQLAIRAIKSVLRQDYSNWEMIIVDDCSTSWEQLQQYVTALNDPRITYIHNDiNSGACAVRNQAIMLA 84

                         90       100
                 ....*....|....*....|....*..
gi 918073597  89 KGKYFTFVDADDWLAPEILGRGLAYMQ 115
Cdd:PRK10018  85 QGEYITGIDDDDEWTPNRLSVFLAHKQ 111
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 15-121 2.15e-08

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 53.73  E-value: 2.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  15 IVPVYNVAPWLDECISSILRAGVSELELLLVDDGSTDGSGAmcdawQVREPHIRVIHQPnAGQSVARNVALSEAKGKYFT 94
Cdd:cd02522    4 IIPTLNEAENLPRLLASLRRLNPLPLEIIVVDGGSTDGTVA-----IARSAGVVVISSP-KGRARQMNAGAAAARGDWLL 77

                         90       100
                 ....*....|....*....|....*..
gi 918073597  95 FVDADDWLAPEILGRGLAYMQAHPEVG 121
Cdd:cd02522   78 FLHADTRLPPDWDAAIIETLRADGAVA 104
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 14-99 4.79e-08

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 52.57  E-value: 4.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  14 FIVPVYN----VAPWLDECISSILRAGVSELELLLVDDGSTDGSGAMCDAWQVREP-HIRVIHQP-NAGQSVARNVALSE 87
Cdd:cd04188    1 VVIPAYNeekrLPPTLEEAVEYLEERPSFSYEIIVVDDGSKDGTAEVARKLARKNPaLIRVLTLPkNRGKGGAVRAGMLA 80

                         90
                 ....*....|..
gi 918073597  88 AKGKYFTFVDAD 99
Cdd:cd04188   81 ARGDYILFADAD 92
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 15-99 6.88e-08

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 52.15  E-value: 6.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  15 IVPVYNVAPWLDECISSILRA-GVSELELLLVDDGSTDGSGAMCDAWQVREPHIRVIHQPN-AGQSVARNVALSEAKGKY 92
Cdd:cd06442    2 IIPTYNERENIPELIERLDAAlKGIDYEIIVVDDNSPDGTAEIVRELAKEYPRVRLIVRPGkRGLGSAYIEGFKAARGDV 81


                 ....*..
gi 918073597  93 FTFVDAD 99
Cdd:cd06442   82 IVVMDAD 88
GT2_HAS cd06434
Hyaluronan synthases catalyze polymerization of hyaluronan; Hyaluronan synthases (HASs) are ...
 12-121 2.99e-06

Hyaluronan synthases catalyze polymerization of hyaluronan; Hyaluronan synthases (HASs) are bi-functional glycosyltransferases that catalyze polymerization of hyaluronan. HASs transfer both GlcUA and GlcNAc in beta-(1,3) and beta-(1,4) linkages, respectively to the hyaluronan chain using UDP-GlcNAc and UDP-GlcUA as substrates. HA is made as a free glycan, not attached to a protein or lipid. HASs do not need a primer for HA synthesis; they initiate HA biosynthesis de novo with only UDP-GlcNAc, UDP-GlcUA, and Mg2+. Hyaluronan (HA) is a linear heteropolysaccharide composed of (1-3)-linked beta-D-GlcUA-beta-D-GlcNAc disaccharide repeats. It can be found in vertebrates and a few microbes and is typically on the cell surface or in the extracellular space, but is also found inside mammalian cells. Hyaluronan has several physiochemical and biological functions such as space filling, lubrication, and providing a hydrated matrix through which cells can migrate.


Pssm-ID: 133056 [Multi-domain]  Cd Length: 235  Bit Score: 47.63  E-value: 2.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  12 LTFIVPVYNVAP-WLDECISSILRAGvsELELLLVDDGSTDGSGAMcDAWQVREPHIRVIHQPNAGQSVARNVALSEAKG 90
Cdd:cd06434    2 VTVIIPVYDEDPdVFRECLRSILRQK--PLEIIVVTDGDDEPYLSI-LSQTVKYGGIFVITVPHPGKRRALAEGIRHVTT 78

                         90       100       110
                 ....*....|....*....|....*....|.
gi 918073597  91 KYFTFVDADDWLAPEILGRGLAYMQAhPEVG 121
Cdd:cd06434   79 DIVVLLDSDTVWPPNALPEMLKPFED-PKVG 108
Glyco_tranf_2_2 pfam10111
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 13-115 5.91e-06

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 313356 [Multi-domain]  Cd Length: 276  Bit Score: 46.89  E-value: 5.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597   13 TFIVPVYNVA--PWLDECISSILRAGVSELELLLVDDGSTDGSGAMCDAWQVREPHIRVIHQPNA--GQSVARNVALSEA 88
Cdd:pfam10111   1 SVVIPVYNGEktHWIQERILNQTFQYDPEFELIIINDGSTDKTLEEVSSIKDHNLQVYYPNAPDTtySLAASRNRGTSHA 80

                          90       100
                  ....*....|....*....|....*..
gi 918073597   89 KGKYFTFVDADDWLAPEILGRGLAYMQ 115
Cdd:pfam10111  81 IGEYISFIDGDCLWSPDKFEKQLKIAT 107
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 40-117 7.37e-06

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 46.51  E-value: 7.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  40 LELLLVDDGSTDGSGAMCD-AWQVREPHIRVIHQ---PNAGQSVARNVALSEAKGKYFTFVDAD-----DWLapeilgrg 110
Cdd:cd04192   29 FEVILVDDHSTDGTVQILEfAAAKPNFQLKILNNsrvSISGKKNALTTAIKAAKGDWIVTTDADcvvpsNWL-------- 100


                 ....*..
gi 918073597 111 LAYMQAH 117
Cdd:cd04192  101 LTFVAFI 107
PRK10714 PRK10714
undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional
 15-115 9.42e-05

undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional


Pssm-ID: 182669 [Multi-domain]  Cd Length: 325  Bit Score: 43.57  E-value: 9.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  15 IVPVYNVAPWLDECISSILRAGVS---ELELLLVDDGSTDGSGAM-CDAWQVREPHI-RVIHQPNAGQSVARNVALSEAK 89
Cdd:PRK10714  11 VIPVYNEQESLPELIRRTTAACESlgkEYEILLIDDGSSDNSAEMlVEAAQAPDSHIvAILLNRNYGQHSAIMAGFSHVT 90

                         90       100
                 ....*....|....*....|....*.
gi 918073597  90 GKYFTFVDADDWLAPEILGRGLAYMQ 115
Cdd:PRK10714  91 GDLIITLDADLQNPPEEIPRLVAKAD 116
GT2_AmsE_like cd04195
GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a ...
 25-174 1.35e-04

GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a glycosyltransferase involved in exopolysaccharide amylovora biosynthesis in Erwinia amylovora. Amylovara is one of the three exopolysaccharide produced by E. amylovora. Amylovara-deficient mutants are non-pathogenic. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133038 [Multi-domain]  Cd Length: 201  Bit Score: 42.30  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  25 LDECISSILRAGVSELELLLVDDGS-TDGSGAMCDAWQvREPHIRVIHQP-NAGQSVARNVALSEAKGKYFTFVDADDWL 102
Cdd:cd04195   15 LREALESILKQTLPPDEVVLVKDGPvTQSLNEVLEEFK-RKLPLKVVPLEkNRGLGKALNEGLKHCTYDWVARMDTDDIS 93

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 918073597 103 APEILGRGLAYMQAHPEV-----GVLEFGYAEVrgleeevfPILGQEETNNAEKVLElFARMKGPIGMPwAKIFRTE 174
Cdd:cd04195   94 LPDRFEKQLDFIEKNPEIdivggGVLEFDSDGN--------DIGKRRLPTSHDDILK-FARRRSPFNHP-TVMFRKS 160
GlcNAc-1-P_transferase cd06436
N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1, ...
 14-121 4.03e-03

N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1,6-N-acetyl-D-glucosamine; N-acetyl-glucosamine transferase is responsible for the synthesis of bacteria Poly-beta-1,6-N-acetyl-D-glucosamine (PGA). Poly-beta-1,6-N-acetyl-D-glucosamine is a homopolymer that serves as an adhesion for the maintenance of biofilm structural stability in diverse eubacteria. N-acetyl-glucosamine transferase is the product of gene pgaC. Genetic analysis indicated that all four genes of the pgaABCD locus were required for the PGA production, pgaC being a glycosyltransferase.


Pssm-ID: 133058 [Multi-domain]  Cd Length: 191  Bit Score: 37.75  E-value: 4.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  14 FIVPVYNVAPWLDECISSILRagVSE-LELLLVDDGSTDGSGAMCDAwQVREPHIRVI--HQPNA--GQSVARNVALSEA 88
Cdd:cd06436    1 VLVPCLNEEAVIQRTLASLLR--NKPnFLVLVIDDASDDDTAGIVRL-AITDSRVHLLrrHLPNArtGKGDALNAAYDQI 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 918073597  89 KGK-----------YFTFVDADDWLAPEILGRGLAYMqAHPEVG 121
Cdd:cd06436   78 RQIlieegadpervIIAVIDADGRLDPNALEAVAPYF-SDPRVA 120
Glyco_tranf_2_4 pfam13704
Glycosyl transferase family 2; Members of this family of prokaryotic proteins include putative ...
 19-99 4.31e-03

Glycosyl transferase family 2; Members of this family of prokaryotic proteins include putative glucosyltransferases,


Pssm-ID: 433416 [Multi-domain]  Cd Length: 97  Bit Score: 36.07  E-value: 4.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597   19 YNVAPWLDECISSILRAGVSELelLLVDDGSTDGSGAMCDAWqvrePHIRVIHQPNAG-----QSVARNVALSEAK-GKY 92
Cdd:pfam13704   1 RNEADILPQWLAHHLALGFDHI--YVYDNGSDDGTAEILARL----PDVSILRSDLSYkdarfQVDWRNALLARYAeADW 74


                  ....*..
gi 918073597   93 FTFVDAD 99
Cdd:pfam13704  75 VLVVDAD 81
pp-GalNAc-T cd02510
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide ...
 15-104 5.53e-03

pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferases (pp-GalNAc-T) initiate the formation of mucin-type, O-linked glycans by catalyzing the transfer of alpha-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to hydroxyl groups of Ser or Thr residues of core proteins to form the Tn antigen (GalNAc-a-1-O-Ser/Thr). These enzymes are type II membrane proteins with a GT-A type catalytic domain and a lectin domain located on the lumen side of the Golgi apparatus. In human, there are 15 isozymes of pp-GalNAc-Ts, representing the largest of all glycosyltransferase families. Each isozyme has unique but partially redundant substrate specificity for glycosylation sites on acceptor proteins.


Pssm-ID: 133004 [Multi-domain]  Cd Length: 299  Bit Score: 37.95  E-value: 5.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918073597  15 IVPVYNVAPwldeciSSILRAGVS-------EL--ELLLVDDGSTDgsgamcDAWQVRE--------PHIRVIHQP-NAG 76
Cdd:cd02510    3 IIIFHNEAL------STLLRTVHSvinrtppELlkEIILVDDFSDK------PELKLLLeeyykkylPKVKVLRLKkREG 70

                         90       100       110
                 ....*....|....*....|....*....|...
gi 918073597  77 QSVARNVALSEAKGKYFTFVDA-----DDWLAP 104
Cdd:cd02510   71 LIRARIAGARAATGDVLVFLDShcevnVGWLEP 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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