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Conserved domains on  [gi|940643666|ref|WP_055016624|]
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MULTISPECIES: ISC system 2Fe-2S type ferredoxin [Pseudoalteromonas]

Protein Classification

2Fe-2S iron-sulfur cluster-binding family protein( domain architecture ID 1376)

2Fe-2S iron-sulfur cluster-binding family protein such as ferredoxin, an iron-sulfur protein transfering electrons in a wide variety of metabolic reactions

Gene Ontology:  GO:0051536

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
fer2 super family cl00159
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in ...
 2-111 4.27e-59

2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.


The actual alignment was detected with superfamily member TIGR02007:

Pssm-ID: 444718 [Multi-domain]  Cd Length: 110  Bit Score: 176.90  E-value: 4.27e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940643666    2 PQIIFLPHPELCPDGAALEAPQGETVLDVALKNGISIPHACEKSCACTTCHLVIREGFDSLDESDELEDDMLDKAWGLEP 81
Cdd:TIGR02007   1 PKIVFLPHEDLCPEGAVVEAKPGETILDVALDNGIEIEHACEKSCACTTCHCIVREGFDSLEEASEQEEDMLDKAWGLEP 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 940643666   82 ESRLGCQAVIKDEDLVVEIPKYNLNIVNEE 111
Cdd:TIGR02007  81 DSRLSCQAVVADEDLVVEIPKYTINHAREA 110
 
Name Accession Description Interval E-value
fdx_isc TIGR02007
ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins ...
 2-111 4.27e-59

ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins associated with and essential to the ISC system of 2Fe-2S cluster assembly. This family is closely related to (but excludes) eukaryotic (mitochondrial) adrenodoxins, which are ferredoxins involved in electron transfer to P450 cytochromes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 131062 [Multi-domain]  Cd Length: 110  Bit Score: 176.90  E-value: 4.27e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940643666    2 PQIIFLPHPELCPDGAALEAPQGETVLDVALKNGISIPHACEKSCACTTCHLVIREGFDSLDESDELEDDMLDKAWGLEP 81
Cdd:TIGR02007   1 PKIVFLPHEDLCPEGAVVEAKPGETILDVALDNGIEIEHACEKSCACTTCHCIVREGFDSLEEASEQEEDMLDKAWGLEP 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 940643666   82 ESRLGCQAVIKDEDLVVEIPKYNLNIVNEE 111
Cdd:TIGR02007  81 DSRLSCQAVVADEDLVVEIPKYTINHAREA 110
Fdx COG0633
Ferredoxin [Energy production and conversion];
1-101 2.77e-24

Ferredoxin [Energy production and conversion];


Pssm-ID: 440398 [Multi-domain]  Cd Length: 87  Bit Score: 87.98  E-value: 2.77e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940643666   1 MPQIIFLPHpelcpdGAALEAPQGETVLDVALKNGISIPHACEkSCACTTCHLVIREGfdsldESDELEDDMLDkAWGLE 80
Cdd:COG0633    1 MPKVTFIPE------GHTVEVPAGESLLEAALRAGIDLPYSCR-SGACGTCHVRVLEG-----EVDHREEDALS-DEERA 67

                         90       100
                 ....*....|....*....|.
gi 940643666  81 PESRLGCQAVIKDeDLVVEIP 101
Cdd:COG0633   68 AGSRLACQARPTS-DLVVELP 87
PLN02593 PLN02593
adrenodoxin-like ferredoxin protein
 14-106 4.36e-23

adrenodoxin-like ferredoxin protein


Pssm-ID: 178203 [Multi-domain]  Cd Length: 117  Bit Score: 85.93  E-value: 4.36e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940643666  14 PDGA--ALEAPQGETVLDVALKNGISIPHACEKSCACTTCHLVI--REGFDSLDESDELEDDMLDKAWGLEPESRLGCQA 89
Cdd:PLN02593   8 KDGEerTVKAPVGMSLLEAAHENDIELEGACEGSLACSTCHVIVmdEKVYNKLPEPTDEENDMLDLAFGLTETSRLGCQV 87

                         90
                 ....*....|....*....
gi 940643666  90 VIKDE--DLVVEIPKYNLN 106
Cdd:PLN02593  88 IAKPEldGMRLALPAATRN 106
fer2 cd00207
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in ...
 14-99 7.24e-14

2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.


Pssm-ID: 238126 [Multi-domain]  Cd Length: 84  Bit Score: 61.64  E-value: 7.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940643666  14 PDGAALEAPQGETVLDVALKNGISIPHACEKScACTTCHLVIREGfdsldeSDELEDDMLDKAWGLEPESRLGCQAVIKD 93
Cdd:cd00207    7 GSGVEVEVPEGETLLDAAREAGIDIPYSCRAG-ACGTCKVEVVEG------EVDQSDPSLLDEEEAEGGYVLACQTRVTD 79


                 ....*.
gi 940643666  94 eDLVVE 99
Cdd:cd00207   80 -GLVIE 84
Fer2 pfam00111
2Fe-2S iron-sulfur cluster binding domain;
11-92 5.46e-10

2Fe-2S iron-sulfur cluster binding domain;


Pssm-ID: 395061 [Multi-domain]  Cd Length: 77  Bit Score: 51.37  E-value: 5.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940643666   11 ELCPDGAALEAPQGET-VLDVALKNGISIPHACEKSCaCTTCHLVIREGFDSLDESdELEDDMLDKAWGLepesrLGCQA 89
Cdd:pfam00111   2 TINGKGVTIEVPDGETtLLDAAEEAGIDIPYSCRGGG-CGTCAVKVLEGEDQSDQS-FLEDDELAAGYVV-----LACQT 74


                  ...
gi 940643666   90 VIK 92
Cdd:pfam00111  75 YPK 77
 
Name Accession Description Interval E-value
fdx_isc TIGR02007
ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins ...
 2-111 4.27e-59

ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins associated with and essential to the ISC system of 2Fe-2S cluster assembly. This family is closely related to (but excludes) eukaryotic (mitochondrial) adrenodoxins, which are ferredoxins involved in electron transfer to P450 cytochromes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 131062 [Multi-domain]  Cd Length: 110  Bit Score: 176.90  E-value: 4.27e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940643666    2 PQIIFLPHPELCPDGAALEAPQGETVLDVALKNGISIPHACEKSCACTTCHLVIREGFDSLDESDELEDDMLDKAWGLEP 81
Cdd:TIGR02007   1 PKIVFLPHEDLCPEGAVVEAKPGETILDVALDNGIEIEHACEKSCACTTCHCIVREGFDSLEEASEQEEDMLDKAWGLEP 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 940643666   82 ESRLGCQAVIKDEDLVVEIPKYNLNIVNEE 111
Cdd:TIGR02007  81 DSRLSCQAVVADEDLVVEIPKYTINHAREA 110
Fdx COG0633
Ferredoxin [Energy production and conversion];
1-101 2.77e-24

Ferredoxin [Energy production and conversion];


Pssm-ID: 440398 [Multi-domain]  Cd Length: 87  Bit Score: 87.98  E-value: 2.77e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940643666   1 MPQIIFLPHpelcpdGAALEAPQGETVLDVALKNGISIPHACEkSCACTTCHLVIREGfdsldESDELEDDMLDkAWGLE 80
Cdd:COG0633    1 MPKVTFIPE------GHTVEVPAGESLLEAALRAGIDLPYSCR-SGACGTCHVRVLEG-----EVDHREEDALS-DEERA 67

                         90       100
                 ....*....|....*....|.
gi 940643666  81 PESRLGCQAVIKDeDLVVEIP 101
Cdd:COG0633   68 AGSRLACQARPTS-DLVVELP 87
PLN02593 PLN02593
adrenodoxin-like ferredoxin protein
 14-106 4.36e-23

adrenodoxin-like ferredoxin protein


Pssm-ID: 178203 [Multi-domain]  Cd Length: 117  Bit Score: 85.93  E-value: 4.36e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940643666  14 PDGA--ALEAPQGETVLDVALKNGISIPHACEKSCACTTCHLVI--REGFDSLDESDELEDDMLDKAWGLEPESRLGCQA 89
Cdd:PLN02593   8 KDGEerTVKAPVGMSLLEAAHENDIELEGACEGSLACSTCHVIVmdEKVYNKLPEPTDEENDMLDLAFGLTETSRLGCQV 87

                         90
                 ....*....|....*....
gi 940643666  90 VIKDE--DLVVEIPKYNLN 106
Cdd:PLN02593  88 IAKPEldGMRLALPAATRN 106
fer2 cd00207
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in ...
 14-99 7.24e-14

2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.


Pssm-ID: 238126 [Multi-domain]  Cd Length: 84  Bit Score: 61.64  E-value: 7.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940643666  14 PDGAALEAPQGETVLDVALKNGISIPHACEKScACTTCHLVIREGfdsldeSDELEDDMLDKAWGLEPESRLGCQAVIKD 93
Cdd:cd00207    7 GSGVEVEVPEGETLLDAAREAGIDIPYSCRAG-ACGTCKVEVVEG------EVDQSDPSLLDEEEAEGGYVLACQTRVTD 79


                 ....*.
gi 940643666  94 eDLVVE 99
Cdd:cd00207   80 -GLVIE 84
NqrF COG2871
Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and ...
 14-107 2.29e-13

Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF is part of the Pathway/BioSystem: Na+-translocating NADH dehydrogenase


Pssm-ID: 442118 [Multi-domain]  Cd Length: 396  Bit Score: 64.50  E-value: 2.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940643666  14 PDGAALEAPQGETVLDVALKNGISIPHACEKSCACTTCHLVIREGFDSLDESDE--LEDDMLDKAWglepesRLGCQAVI 91
Cdd:COG2871   41 GDGKEIEVEEGQTLLDALLRQGIFLPSACGGGGTCGQCKVKVLEGGGDILPTETfhLSDRERKEGY------RLACQVKV 114

                         90
                 ....*....|....*.
gi 940643666  92 KdEDLVVEIPKYNLNI 107
Cdd:COG2871  115 K-SDMEIEVPEEVFGV 129
COG3894 COG3894
Uncharacterized 2Fe-2S and 4Fe-4S clusters-containing protein, contains DUF4445 domain ...
 1-101 1.67e-12

Uncharacterized 2Fe-2S and 4Fe-4S clusters-containing protein, contains DUF4445 domain [Function unknown];


Pssm-ID: 443101 [Multi-domain]  Cd Length: 621  Bit Score: 62.13  E-value: 1.67e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940643666   1 MPQIIFLPHpelcpdGAALEAPQGETVLDVALKNGISIPHACEKSCACTTCHLVIREGFDSLDESDE---LEDDMLDKAW 77
Cdd:COG3894    3 KVKVTFLPS------GKRVEVEAGTTLLDAAREAGVDIDAPCGGRGTCGKCKVKVEEGEFSPVTEEErrlLSPEELAEGY 76

                         90       100
                 ....*....|....*....|....
gi 940643666  78 glepesRLGCQAVIKdEDLVVEIP 101
Cdd:COG3894   77 ------RLACQARVL-GDLVVEVP 93
Fer2 pfam00111
2Fe-2S iron-sulfur cluster binding domain;
11-92 5.46e-10

2Fe-2S iron-sulfur cluster binding domain;


Pssm-ID: 395061 [Multi-domain]  Cd Length: 77  Bit Score: 51.37  E-value: 5.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940643666   11 ELCPDGAALEAPQGET-VLDVALKNGISIPHACEKSCaCTTCHLVIREGFDSLDESdELEDDMLDKAWGLepesrLGCQA 89
Cdd:pfam00111   2 TINGKGVTIEVPDGETtLLDAAEEAGIDIPYSCRGGG-CGTCAVKVLEGEDQSDQS-FLEDDELAAGYVV-----LACQT 74


                  ...
gi 940643666   90 VIK 92
Cdd:pfam00111  75 YPK 77
PTZ00490 PTZ00490
Ferredoxin superfamily; Provisional
 26-106 6.58e-09

Ferredoxin superfamily; Provisional


Pssm-ID: 185668  Cd Length: 143  Bit Score: 50.25  E-value: 6.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940643666  26 TVLDVALKNGISIPHA------------CEKSCACTTCHLVIREG-FDSLDESDELEDDMLDKAWGLEPESRLGCQAVIK 92
Cdd:PTZ00490  46 THCDVEVPVGMSLMHAlrdvakldvegtCNGCMQCATCHVYLSAAsFKKLGGPSEEEEDVLAKALDVKETSRLACQVDLT 125

                         90
                 ....*....|....*.
gi 940643666  93 DE--DLVVEIPKYNLN 106
Cdd:PTZ00490 126 PEmdGLEVELPSYVTN 141
PRK07609 PRK07609
CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated
 14-58 2.79e-06

CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated


Pssm-ID: 181058 [Multi-domain]  Cd Length: 339  Bit Score: 44.09  E-value: 2.79e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 940643666  14 PDGAALEAPQGETVLDVALKNGISIPHACeKSCACTTCHLVIREG 58
Cdd:PRK07609   9 PSGRQFTAEPDETILDAALRQGIHLPYGC-KNGACGSCKGRLLEG 52
NuoG COG1034
NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production ...
 15-42 3.46e-06

NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440657 [Multi-domain]  Cd Length: 453  Bit Score: 44.06  E-value: 3.46e-06
                         10        20
                 ....*....|....*....|....*...
gi 940643666  15 DGAALEAPQGETVLDVALKNGISIPHAC 42
Cdd:COG1034    7 DGKEVEVPKGTTVLQAAEKAGIEIPRFC 34
Fer2_4 pfam13510
2Fe-2S iron-sulfur cluster binding domain; The 2Fe-2S ferredoxin family have a general core ...
 15-42 4.54e-06

2Fe-2S iron-sulfur cluster binding domain; The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which a beta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated. This cluster appears within sarcosine oxidase proteins.


Pssm-ID: 433268 [Multi-domain]  Cd Length: 82  Bit Score: 41.37  E-value: 4.54e-06
                          10        20
                  ....*....|....*....|....*...
gi 940643666   15 DGAALEAPQGETVLDVALKNGISIPHAC 42
Cdd:pfam13510   9 DGRPVTAPEGDTIAAALLANGVRVPRSC 36
PRK08493 PRK08493
NADH-quinone oxidoreductase subunit G;
15-51 7.51e-05

NADH-quinone oxidoreductase subunit G;


Pssm-ID: 236277 [Multi-domain]  Cd Length: 819  Bit Score: 40.46  E-value: 7.51e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 940643666  15 DGAALEAPQGETVLDVALKNGISIPHACEKSC-----ACTTC 51
Cdd:PRK08493   7 NGKECEAQEGEYILNVARRNGIFIPAICYLSGcsptlACRLC 48
petF CHL00134
ferredoxin; Validated
 17-79 1.02e-04

ferredoxin; Validated


Pssm-ID: 177056 [Multi-domain]  Cd Length: 99  Bit Score: 38.16  E-value: 1.02e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 940643666  17 AALEAPQGETVLDVALKNGISIPHACeKSCACTTCHLVIREGfdSLDESDE--LEDDMLDKAWGL 79
Cdd:CHL00134  17 VTIDCPDDVYILDAAEEQGIDLPYSC-RAGACSTCAGKVTEG--TVDQSDQsfLDDDQLEAGFVL 78
PRK05713 PRK05713
iron-sulfur-binding ferredoxin reductase;
10-100 1.17e-04

iron-sulfur-binding ferredoxin reductase;


Pssm-ID: 235575 [Multi-domain]  Cd Length: 312  Bit Score: 39.71  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940643666  10 PELCPDGAALEAPQGETVLDVALKNGISIPHACEK-SCACTTCHLVIREGFDSLDESdeLEDDMLDKAWglepesRLGCQ 88
Cdd:PRK05713   2 PELRVGERRWSVPAGSNLLDALNAAGVAVPYSCRAgSCHACLVRCLQGEPEDALPEA--LAAEKREQGW------RLACQ 73

                         90
                 ....*....|..
gi 940643666  89 AVIkDEDLVVEI 100
Cdd:PRK05713  74 CRV-VGDLRVEV 84
PTZ00038 PTZ00038
ferredoxin; Provisional
 14-79 2.48e-04

ferredoxin; Provisional


Pssm-ID: 240237 [Multi-domain]  Cd Length: 191  Bit Score: 38.28  E-value: 2.48e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 940643666  14 PDG-AALEAPQGETVLDVALKNGISIPHACeKSCACTTCHLVIREGfdSLDESDE--LEDDMLDKAWGL 79
Cdd:PTZ00038 103 PDGeKVIECDEDEYILDAAERQGVELPYSC-RGGSCSTCAAKLLEG--EVDNEDQsyLDDEQLKKGYCL 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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