NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|948287697|ref|WP_056932052|]
View 

MULTISPECIES: protein translocase subunit SecF [Stenotrophomonas]

Protein Classification

protein translocase subunit SecF( domain architecture ID 11417410)

protein translocase subunit SecF is part of the Sec protein translocase complex; SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA

Gene Ontology:  GO:0015450|GO:0043952|GO:0065002
TCDB:  2.A.6.4

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SecF COG0341
Preprotein translocase subunit SecF [Intracellular trafficking, secretion, and vesicular ...
 8-280 3.39e-100

Preprotein translocase subunit SecF [Intracellular trafficking, secretion, and vesicular transport];


:

Pssm-ID: 440110 [Multi-domain]  Cd Length: 291  Bit Score: 296.19  E-value: 3.39e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697   8 IVPNDTNIDFMRHRKPVLALMVALLLVSLAIIGFKGFNYALEFTGGTVVRTHFEKSVDVEAVRERLATAGFENAQVQSVG 87
Cdd:COG0341    2 LFPGNTNIDFMKKRKIWFAISAVLILASIVSLFTRGLNLGIDFTGGTLIEVSFEQPVDLEEVREALEEAGLGDASVQTFG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697  88 GGNDLMIRLPPEGEhnNAADAAQKVAEKVGAAISTADNVATtqpgEFVGPQVGKDLVMNGIYATLFMVIGFLIYIAARFE 167
Cdd:COG0341   82 SDNDVLIRTPPLDG--ESAEEVEKVRAALKEAFGDVEIVRV----EFVGPTVGKELTRKALLALLVALIGILIYIAFRFE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697 168 WKFAMVASLTAFFDLILTVAYMSLLGREFDLTVLAGMLSVMGFAINDIIVVFDRVRENFRSLRVEPL-EVLNRSINQTLS 246
Cdd:COG0341  156 WRFAVGAVVALLHDVLITLGIFSLFGLEFDLTFIAALLTIIGYSLNDTVVVFDRIRENLRKYRKMTLaEIINLSINQTLS 235

                        250       260       270
                 ....*....|....*....|....*....|....
gi 948287697 247 RTVITAVLFFLSALALYLYGGESMEGLAETHMVG 280
Cdd:COG0341  236 RTINTSLTTLLVVLALLFFGGETLRDFALALLIG 269
 
Name Accession Description Interval E-value
SecF COG0341
Preprotein translocase subunit SecF [Intracellular trafficking, secretion, and vesicular ...
 8-280 3.39e-100

Preprotein translocase subunit SecF [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440110 [Multi-domain]  Cd Length: 291  Bit Score: 296.19  E-value: 3.39e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697   8 IVPNDTNIDFMRHRKPVLALMVALLLVSLAIIGFKGFNYALEFTGGTVVRTHFEKSVDVEAVRERLATAGFENAQVQSVG 87
Cdd:COG0341    2 LFPGNTNIDFMKKRKIWFAISAVLILASIVSLFTRGLNLGIDFTGGTLIEVSFEQPVDLEEVREALEEAGLGDASVQTFG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697  88 GGNDLMIRLPPEGEhnNAADAAQKVAEKVGAAISTADNVATtqpgEFVGPQVGKDLVMNGIYATLFMVIGFLIYIAARFE 167
Cdd:COG0341   82 SDNDVLIRTPPLDG--ESAEEVEKVRAALKEAFGDVEIVRV----EFVGPTVGKELTRKALLALLVALIGILIYIAFRFE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697 168 WKFAMVASLTAFFDLILTVAYMSLLGREFDLTVLAGMLSVMGFAINDIIVVFDRVRENFRSLRVEPL-EVLNRSINQTLS 246
Cdd:COG0341  156 WRFAVGAVVALLHDVLITLGIFSLFGLEFDLTFIAALLTIIGYSLNDTVVVFDRIRENLRKYRKMTLaEIINLSINQTLS 235

                        250       260       270
                 ....*....|....*....|....*....|....
gi 948287697 247 RTVITAVLFFLSALALYLYGGESMEGLAETHMVG 280
Cdd:COG0341  236 RTINTSLTTLLVVLALLFFGGETLRDFALALLIG 269
3a0501s07 TIGR00966
protein-export membrane protein SecF; This bacterial protein is always found with the ...
 43-280 4.46e-68

protein-export membrane protein SecF; This bacterial protein is always found with the homologous protein-export membrane protein SecD. In numerous lineages, this protein occurs as a SecDF fusion protein. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273368 [Multi-domain]  Cd Length: 246  Bit Score: 212.90  E-value: 4.46e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697   43 GFNYALEFTGGTVVRTHFEKSVDVEAVRERLATAGFENAQVQSVGGGNDLMIRLPPEGEHNNAadaaqKVAEKVGAAIST 122
Cdd:TIGR00966   1 GFNFGIDFTGGTVIETRLEQAADVAEVRDVLEKAGIEGVVIQEFGSSHTIMIRIPTLDTEQSE-----ELREALEEALKN 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697  123 ADNVATTQPGEFVGPQVGKDLVMNGIYATLFMVIGFLIYIAARFEWKFAMVASLTAFFDLILTVAYMSLLGREFDLTVLA 202
Cdd:TIGR00966  76 VDPDAEIRSIDAVGPSVGGELARKAVLALLAALVLILIYITVRFEWRFALGAIVALVHDVIITVGVYSLFGIEVNLTTVA 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 948287697  203 GMLSVMGFAINDIIVVFDRVRENFRSLRVEPL-EVLNRSINQTLSRTVITAVLFFLSALALYLYGGESMEGLAETHMVG 280
Cdd:TIGR00966 156 ALLTIIGYSINDTVVVFDRIRENLRKYTRKTFtEVINLSINQTLSRTINTSLTTLLAVLALYVFGGGVIKDFSLALLVG 234
PRK13024 PRK13024
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
 7-274 5.08e-68

bifunctional preprotein translocase subunit SecD/SecF; Reviewed


Pssm-ID: 237276 [Multi-domain]  Cd Length: 755  Bit Score: 225.88  E-value: 5.08e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697   7 HIVPNDTNIDFMRHRKPVLALMVALLLVSLAIIGFKGFNYALEFTGGTVVRTHFEKSVDVEAVRERLATAGFENAQVQSV 86
Cdd:PRK13024 441 EGVTIFDRIDFVKKRKWFLIFSIVLVIAGIIIFFIFGLNLGIDFTGGTRYEIRTDQPVDLEQVRADLKELGLGEVNIVTF 520

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697  87 GGG-NDLMIRLPPEGEHNNAADaaQKVAEKVGAAISTADNVATTQPgEFVGPQVGKDLVMNGIYATLFMVIGFLIYIAAR 165
Cdd:PRK13024 521 GSDnNQVLVRTYGILSDDEEAD--TEIVAKLKNALKNDKGGTIPSS-ETVGPTVGKELARNAIIAVLIALIGILLYILIR 597

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697 166 FEWKFAMVASLTAFFDLILTVAYMSLLGREFDLTVLAGMLSVMGFAINDIIVVFDRVRENFRSLRVEPL-EVLNRSINQT 244
Cdd:PRK13024 598 FEWTFSLGAILALLHDVLIVIGFFSLFRLEVDLTFIAAILTIIGYSINDTVVVFDRIRENLRLYKKKDLrEIVNKSINQT 677

                        250       260       270
                 ....*....|....*....|....*....|
gi 948287697 245 LSRTVITAVLFFLSALALYLYGGESMEGLA 274
Cdd:PRK13024 678 LSRTINTSLTTLLVLLALLIFGGSSLRNFS 707
SecD_SecF pfam02355
Protein export membrane protein; This family consists of various prokaryotic SecD and SecF ...
 133-280 1.04e-45

Protein export membrane protein; This family consists of various prokaryotic SecD and SecF protein export membrane proteins. This SecD and SecF proteins are part of the multimeric protein export complex comprising SecA, D, E, F, G, Y, and YajC. SecD and SecF are required to maintain a proton motive force.


Pssm-ID: 280510 [Multi-domain]  Cd Length: 189  Bit Score: 153.53  E-value: 1.04e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697  133 EFVGPQVGKDLVMNGIYATLFMVIGFLIYIAARFEWKFAMVASLTAFFDLILTVAYMSLLGREFDLTVLAGMLSVMGFAI 212
Cdd:pfam02355  19 ETVGPTVGSELARKAVLALLFALLLILIYVGLRFEWRFALGAIIALAHDVIITVGVFSLFGIEVDLATVAALLTIIGYSV 98

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 948287697  213 NDIIVVFDRVRENFRSLRVEPL-EVLNRSINQTLSRTVITAVLFFLSALALYLYGGESMEGLAETHMVG 280
Cdd:pfam02355  99 NDTVVVFDRVRENLRKKTRATLnEIMNLSINQTLTRTINTSLTTLLVVVALFVFGGGSLKDFSLALLVG 167
RND_1 NF037998
protein translocase SecDF, variant type; Members of this family are identified by TCDB as ...
 149-235 4.23e-04

protein translocase SecDF, variant type; Members of this family are identified by TCDB as belonging to 2.A.6.4.4, a variant 12-TM type SecDF, as found in Spiroplasma, Mesoplasma, and Acholeplasma.


Pssm-ID: 468306  Cd Length: 1237  Bit Score: 42.07  E-value: 4.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697  149 YATLFMVIGFLIYIAARFEWKFAMVASLTAFFDLILTVAYMSLLGREFDLTVLAGMLSVMGFAINDIIVVFDRVRENFRS 228
Cdd:NF037998  961 ISFAIILLALIVYILIRFKWTYYVALALAIVFAPAITVSIVIIFRVPITFEILIAFVSIIGFAIASAIIILGKAKSLISS 1040


                  ....*..
gi 948287697  229 LRVEPLE 235
Cdd:NF037998 1041 KNKKELE 1047
 
Name Accession Description Interval E-value
SecF COG0341
Preprotein translocase subunit SecF [Intracellular trafficking, secretion, and vesicular ...
 8-280 3.39e-100

Preprotein translocase subunit SecF [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440110 [Multi-domain]  Cd Length: 291  Bit Score: 296.19  E-value: 3.39e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697   8 IVPNDTNIDFMRHRKPVLALMVALLLVSLAIIGFKGFNYALEFTGGTVVRTHFEKSVDVEAVRERLATAGFENAQVQSVG 87
Cdd:COG0341    2 LFPGNTNIDFMKKRKIWFAISAVLILASIVSLFTRGLNLGIDFTGGTLIEVSFEQPVDLEEVREALEEAGLGDASVQTFG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697  88 GGNDLMIRLPPEGEhnNAADAAQKVAEKVGAAISTADNVATtqpgEFVGPQVGKDLVMNGIYATLFMVIGFLIYIAARFE 167
Cdd:COG0341   82 SDNDVLIRTPPLDG--ESAEEVEKVRAALKEAFGDVEIVRV----EFVGPTVGKELTRKALLALLVALIGILIYIAFRFE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697 168 WKFAMVASLTAFFDLILTVAYMSLLGREFDLTVLAGMLSVMGFAINDIIVVFDRVRENFRSLRVEPL-EVLNRSINQTLS 246
Cdd:COG0341  156 WRFAVGAVVALLHDVLITLGIFSLFGLEFDLTFIAALLTIIGYSLNDTVVVFDRIRENLRKYRKMTLaEIINLSINQTLS 235

                        250       260       270
                 ....*....|....*....|....*....|....
gi 948287697 247 RTVITAVLFFLSALALYLYGGESMEGLAETHMVG 280
Cdd:COG0341  236 RTINTSLTTLLVVLALLFFGGETLRDFALALLIG 269
3a0501s07 TIGR00966
protein-export membrane protein SecF; This bacterial protein is always found with the ...
 43-280 4.46e-68

protein-export membrane protein SecF; This bacterial protein is always found with the homologous protein-export membrane protein SecD. In numerous lineages, this protein occurs as a SecDF fusion protein. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273368 [Multi-domain]  Cd Length: 246  Bit Score: 212.90  E-value: 4.46e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697   43 GFNYALEFTGGTVVRTHFEKSVDVEAVRERLATAGFENAQVQSVGGGNDLMIRLPPEGEHNNAadaaqKVAEKVGAAIST 122
Cdd:TIGR00966   1 GFNFGIDFTGGTVIETRLEQAADVAEVRDVLEKAGIEGVVIQEFGSSHTIMIRIPTLDTEQSE-----ELREALEEALKN 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697  123 ADNVATTQPGEFVGPQVGKDLVMNGIYATLFMVIGFLIYIAARFEWKFAMVASLTAFFDLILTVAYMSLLGREFDLTVLA 202
Cdd:TIGR00966  76 VDPDAEIRSIDAVGPSVGGELARKAVLALLAALVLILIYITVRFEWRFALGAIVALVHDVIITVGVYSLFGIEVNLTTVA 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 948287697  203 GMLSVMGFAINDIIVVFDRVRENFRSLRVEPL-EVLNRSINQTLSRTVITAVLFFLSALALYLYGGESMEGLAETHMVG 280
Cdd:TIGR00966 156 ALLTIIGYSINDTVVVFDRIRENLRKYTRKTFtEVINLSINQTLSRTINTSLTTLLAVLALYVFGGGVIKDFSLALLVG 234
PRK13024 PRK13024
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
 7-274 5.08e-68

bifunctional preprotein translocase subunit SecD/SecF; Reviewed


Pssm-ID: 237276 [Multi-domain]  Cd Length: 755  Bit Score: 225.88  E-value: 5.08e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697   7 HIVPNDTNIDFMRHRKPVLALMVALLLVSLAIIGFKGFNYALEFTGGTVVRTHFEKSVDVEAVRERLATAGFENAQVQSV 86
Cdd:PRK13024 441 EGVTIFDRIDFVKKRKWFLIFSIVLVIAGIIIFFIFGLNLGIDFTGGTRYEIRTDQPVDLEQVRADLKELGLGEVNIVTF 520

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697  87 GGG-NDLMIRLPPEGEHNNAADaaQKVAEKVGAAISTADNVATTQPgEFVGPQVGKDLVMNGIYATLFMVIGFLIYIAAR 165
Cdd:PRK13024 521 GSDnNQVLVRTYGILSDDEEAD--TEIVAKLKNALKNDKGGTIPSS-ETVGPTVGKELARNAIIAVLIALIGILLYILIR 597

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697 166 FEWKFAMVASLTAFFDLILTVAYMSLLGREFDLTVLAGMLSVMGFAINDIIVVFDRVRENFRSLRVEPL-EVLNRSINQT 244
Cdd:PRK13024 598 FEWTFSLGAILALLHDVLIVIGFFSLFRLEVDLTFIAAILTIIGYSINDTVVVFDRIRENLRLYKKKDLrEIVNKSINQT 677

                        250       260       270
                 ....*....|....*....|....*....|
gi 948287697 245 LSRTVITAVLFFLSALALYLYGGESMEGLA 274
Cdd:PRK13024 678 LSRTINTSLTTLLVLLALLIFGGSSLRNFS 707
PRK14726 PRK14726
protein translocase subunit SecDF;
9-317 2.19e-54

protein translocase subunit SecDF;


Pssm-ID: 237805 [Multi-domain]  Cd Length: 855  Bit Score: 189.93  E-value: 2.19e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697   9 VPNDTNIDFMRHRKPVLALMVALLLVSLAIIGFKGFNYALEFTGGTVVRTHFEKSV-DVEAVRERLATAGFENAQVQSVG 87
Cdd:PRK14726 541 LFEGANIRFMGIRRYVFTLSAALSLASLVLFATVGLNLGIDFTGGSLIEVRAKQGNaDIADIRARLNELNLGEVQVERFG 620

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697  88 GGNDLMIRLPPEGEHNNAAdaaQKVAEKVGAAISTADNVATTqpgEFVGPQVGKDLVMNGIYATLFMVIGFLIYIAARFE 167
Cdd:PRK14726 621 SPRDALIRIASQDGGENAE---QSAVTLVRGELEDDYDFRRV---EVVGPAVSGELTMAATLGVLAALAAILIYIWIRFE 694

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697 168 WKFAMVASLTAFFDLILTVAYMSLLGREFDLTVLAGMLSVMGFAINDIIVVFDRVRENFRSLRVEPLEVL-NRSINQTLS 246
Cdd:PRK14726 695 WQFAVGAIIATLHDVILTLGLFVLTGIEFNLTSIAAILTIVGYSLNDTVVVYDRVRENLRRYKKMPLPILiDASINQTLS 774

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 948287697 247 RTVITAVLFFLSALALYLYGGESMEGLAETHMVGAVIVVVSSIIVAVPLLSIgpFKvskqdLLPKAKDVEE 317
Cdd:PRK14726 775 RTVLTSATTLLALLALYLFGGEVIRSFTFAMLFGVAVGTFSSIYIAAPVLIV--FK-----LRPESLDGEE 838
SecD_SecF pfam02355
Protein export membrane protein; This family consists of various prokaryotic SecD and SecF ...
 133-280 1.04e-45

Protein export membrane protein; This family consists of various prokaryotic SecD and SecF protein export membrane proteins. This SecD and SecF proteins are part of the multimeric protein export complex comprising SecA, D, E, F, G, Y, and YajC. SecD and SecF are required to maintain a proton motive force.


Pssm-ID: 280510 [Multi-domain]  Cd Length: 189  Bit Score: 153.53  E-value: 1.04e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697  133 EFVGPQVGKDLVMNGIYATLFMVIGFLIYIAARFEWKFAMVASLTAFFDLILTVAYMSLLGREFDLTVLAGMLSVMGFAI 212
Cdd:pfam02355  19 ETVGPTVGSELARKAVLALLFALLLILIYVGLRFEWRFALGAIIALAHDVIITVGVFSLFGIEVDLATVAALLTIIGYSV 98

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 948287697  213 NDIIVVFDRVRENFRSLRVEPL-EVLNRSINQTLSRTVITAVLFFLSALALYLYGGESMEGLAETHMVG 280
Cdd:pfam02355  99 NDTVVVFDRVRENLRKKTRATLnEIMNLSINQTLTRTINTSLTTLLVVVALFVFGGGSLKDFSLALLVG 167
secF PRK13021
preprotein translocase subunit SecF; Reviewed
 35-280 3.77e-39

preprotein translocase subunit SecF; Reviewed


Pssm-ID: 237274 [Multi-domain]  Cd Length: 297  Bit Score: 139.99  E-value: 3.77e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697  35 SLAIIGFKGFNYALEFTGGTVVRTHFEKSVDVEAVRERLATAGFENAQVQSVGGGNDLMIRLPPEGEHNNAADAAQKVAE 114
Cdd:PRK13021  24 SLTIIGVKGFNWGLDFTGGVVTEVQLDRKITSSELQPLLNAAYQQEVSVISASEPGRWVLRYAPADTAQSNVDIQQALAP 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697 115 kvgaaISTADNVATTQpgeFVGPQVGKDLVMNGIYATLFMVIGFLIYIAARFEWKFAMVASLTAFFDLILTVAYMSLLGR 194
Cdd:PRK13021 104 -----LGTEVQVLNSS---IVGPQVGQELAEQGGLALLVAMLCILGYLSYRFEWRLASGALFALVHDVIFVLAFFALTQM 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697 195 EFDLTVLAGMLSVMGFAINDIIVVFDRVREnfrSLRVEP----LEVLNRSINQTLSRTVITAVLFFLSALALYLYGGESM 270
Cdd:PRK13021 176 EFNLTVLAAVLAILGYSLNDSIIIADRIRE---LLIAKPklaiQEINNQAIVATFSRTMVTSGTTLMTVGALWIMGGGPL 252

                        250
                 ....*....|
gi 948287697 271 EGLAETHMVG 280
Cdd:PRK13021 253 EGFSIAMFIG 262
2A0604s01 TIGR00916
protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY ...
 134-280 7.05e-38

protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY proteins form the protein translocation appartus in prokaryotes. This family is specific for the SecD and SecF proteins. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273336 [Multi-domain]  Cd Length: 192  Bit Score: 133.15  E-value: 7.05e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697  134 FVGPQVGKDLVMNGIYATLFMVIGFLIYIAARFEWKFAMVASLTAFFDLILTVAYMSLLGREFDLTVLAGMLSVMGFAIN 213
Cdd:TIGR00916  36 TVGPTLGGELIKAGIIALLIGLVLVLLYMLLRYEWRGAIAAIAALVHDVILILGVLSLFGATLTLPGIAGLLTIIGYSVD 115

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 948287697  214 DIIVVFDRVRENFRSL-RVEPLEVLNRSINQTLSRTVITAVLFFLSALALYLYGGESMEGLAETHMVG 280
Cdd:TIGR00916 116 DTVVIFDRIREELRKYkGRTFREAINLGINQTLSRIIDTNVTTLLAVLALYVFGGGAIKGFALTLGIG 183
PRK13023 PRK13023
protein translocase subunit SecDF;
6-296 3.25e-34

protein translocase subunit SecDF;


Pssm-ID: 171842 [Multi-domain]  Cd Length: 758  Bit Score: 132.43  E-value: 3.25e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697   6 LHIVPNDTNIDFMRHRKPVLALMVALLLVSLAIIGFKGFNYALEFTGGTVVRTHFEK-SVDVEAVRERLATAGFENAQVQ 84
Cdd:PRK13023 444 LKLVPTVTHIPFMRLQFVTLGISVLACAIVVALFVNIGFNYGIDFRGGSMVELQARNgDANLEDINERLAELNIDSARVL 523

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697  85 SVGGGNDLMIRLppeGEHNNAADAAQKVAEKVGAAIstaDNVATTQPGEFVGPQVGKDLVMNGIYATLFMVIGFLIYIAA 164
Cdd:PRK13023 524 PAKSPRSALVII---GSQEVGDDAEQTVAVKLRGEF---EQDYSFQRVDVVGPTVSEQLSRAGVLAVILSLIGIFIYVWF 597

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697 165 RFEWKFAMVASLTAFFDLILTVAYMSLLGREFDLTVLAGMLSVMGFAINDIIVVFDRVRENFRSLRVEPL-EVLNRSINQ 243
Cdd:PRK13023 598 RFRWQLALGAVLSTLHDVVILSGMFIVFRMEFNLWSVAAILTIIGYSLNDTVVIYDRVRENLRRYKSAPLpAIIDASINQ 677

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 948287697 244 TLSRTVITAVLFFLSALALYLYGGESMEGLAETHMVGAVIVVVSSIIVAVPLL 296
Cdd:PRK13023 678 TLSRTLLTSFVTFLAHVPLYAFGGSEIRMFALALSVGIIVASYSSIFIAAPLL 730
PRK12911 PRK12911
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
 159-307 4.47e-14

bifunctional preprotein translocase subunit SecD/SecF; Reviewed


Pssm-ID: 171815 [Multi-domain]  Cd Length: 1403  Bit Score: 72.97  E-value: 4.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697  159 LIYIAARFEWKFAMVASLTAFFDLILT----VAYMSLLGR-EFDLTVLAGMLSVMGFAINDIIVVFDRVRENFRSLRVEP 233
Cdd:PRK12911 1248 LLYVSLRFEWRYAFSAICALIHDLLATcavlVALHFFLQKiQIDLQAIGALMTVLGYSLNNTLIIFDRIREDRQEKLFTP 1327

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 948287697  234 LEVL-NRSINQTLSRTVITAVLfFLSALALYLY-GGESMEGLAETHMVGAVIVVVSSIIVAVPLLSigpFKVSKQD 307
Cdd:PRK12911 1328 MPILiNDALQKTLGRTVMTTAT-TLSVLLILLFvGGGSIFNFAFIMTIGILLGTLSSLYIAPPLLL---FMVRKEE 1399
secD TIGR01129
protein-export membrane protein SecD; Members of this family are highly variable in length ...
 135-280 2.56e-12

protein-export membrane protein SecD; Members of this family are highly variable in length immediately after the well-conserved motif LGLGLXGG at the amino-terminal end of this model. Archaeal homologs are not included in the seed and score between the trusted and noise cutoffs. SecD from Mycobacterium tuberculosis has a long Pro-rich insert. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273456 [Multi-domain]  Cd Length: 397  Bit Score: 66.93  E-value: 2.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697  135 VGPQVGKDLVMNGIYATLFMVIGFLIYIAARFEWkFAMVASLTAFFDLILTVAYMSLLGREFDLTVLAGMLSVMGFAIND 214
Cdd:TIGR01129 238 IGPSLGADSIEAGIKAGLIGLVLVLVFMILYYRL-FGLIAAIALVINIVLILAILSAFGATLTLPGIAGLILTIGMAVDA 316

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 948287697  215 IIVVFDRVRENFRsLRVEPLEVLNRSINQTLSRTVITAVLFFLSALALYLYGGESMEGLAETHMVG 280
Cdd:TIGR01129 317 NVLIYERIKEELR-LGKSVRQAIEAGFERAFSTIFDANITTLIAALILYVFGTGPVKGFAVTLAIG 381
PRK14726 PRK14726
protein translocase subunit SecDF;
135-280 1.02e-11

protein translocase subunit SecDF;


Pssm-ID: 237805 [Multi-domain]  Cd Length: 855  Bit Score: 65.90  E-value: 1.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697 135 VGPQVGKDLVMNGIYATLFMVIG--FLIYIAARFewkFAMVASLTAFFDLILTVAYMSLLGREFDLTVLAGMLSVMGFAI 212
Cdd:PRK14726 362 VGPGLGADSIAAGLVAGLIAAILvaALMIGFYGF---LGVIAVIALIVNVVLIIAVLSLLGATLTLPGIAGIVLTIGMAV 438

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 948287697 213 NDIIVVFDRVRENFRSLRvePL-EVLNRSINQTLSRTVITAVLFFLSALALYLYGGESMEGLAETHMVG 280
Cdd:PRK14726 439 DSNVLIYERIREEEKTGH--SLiQALDRGFSRALATIVDANVTILIAAVILFFLGSGAVRGFAVTLAVG 505
SecD COG0342
Preprotein translocase subunit SecD [Intracellular trafficking, secretion, and vesicular ...
 135-280 1.96e-09

Preprotein translocase subunit SecD [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440111 [Multi-domain]  Cd Length: 434  Bit Score: 58.20  E-value: 1.96e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697 135 VGPQVGKDLVMNGIYATLFMVIGFLIYIAARFeWKFAMVASLTAFFDLILTVAYMSLLGREFDLTVLAGMLSVMGFAIND 214
Cdd:COG0342  261 VGPTLGADSIEKGLIAGLIGLLLVALFMLLYY-RLPGLVANIALALNVVLLLGVLSLLGATLTLPGIAGIILTIGMAVDA 339

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 948287697 215 IIVVFDRVRE---NFRSLRveplevlnRSINQTLSR---TVITA-VLFFLSALALYLYGGESMEGLAETHMVG 280
Cdd:COG0342  340 NVLIFERIREelrAGRSLR--------AAIEAGFKRafsTILDAnVTTLIAAVVLFVLGTGPVKGFAVTLILG 404
secD PRK05812
preprotein translocase subunit SecD; Reviewed
 135-280 2.50e-08

preprotein translocase subunit SecD; Reviewed


Pssm-ID: 235615 [Multi-domain]  Cd Length: 462  Bit Score: 54.85  E-value: 2.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697 135 VGPQVGKDLVMNGIYAtlfMVIGF---LIYIAA--RFewkFAMVASLTAFFDLILTVAYMSLLGREFDLTVLAGMLSVMG 209
Cdd:PRK05812 287 IGPSLGADSIRAGLIA---GLIGLalvLLFMILyyRL---FGLIANIALVANLVLILAVLSLLGATLTLPGIAGIVLTIG 360

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 948287697 210 FAINDIIVVFDRVRE---NFRSLRveplevlnRSINQTLSR---TVITA-VLFFLSALALYLYGGESMEGLAETHMVG 280
Cdd:PRK05812 361 MAVDANVLIFERIREelrEGRSLR--------SAIEAGFKRafsTILDSnITTLIAAIILYALGTGPVKGFAVTLGIG 430
PRK08578 PRK08578
preprotein translocase subunit SecF; Reviewed
 35-215 3.41e-07

preprotein translocase subunit SecF; Reviewed


Pssm-ID: 236302 [Multi-domain]  Cd Length: 292  Bit Score: 50.70  E-value: 3.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697  35 SLAIIG------FKGFNYALEFTGGTVVrTHFEKSVDVEAVRERLATagfENAQVQSVGGGNDLMIRLPPEGehnnaADA 108
Cdd:PRK08578  27 SLLLLGgtfattGSPVKLGIDFTGGTEI-TIQTNDASPDELESALSG---EPGVDVRKGSGNGYIITFGSGD-----DTD 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697 109 AQKVAEKVGAAISTADNVATTQPGEFVGPQVGKDLVMNGIYATLFMVIGFLIYIAARFEW---KFAMVASltAFFDLILT 185
Cdd:PRK08578  98 VDKLADAVKEFFNVDSISELNYSEKQIGPTFGSQFQEQALKAVGFAFIGMAVVVFLIFRTpvpSLAVILS--AFSDIIIA 175

                        170       180       190
                 ....*....|....*....|....*....|.
gi 948287697 186 VAYMSLLGREFDLTVLAGMLSVMGFAIN-DI 215
Cdd:PRK08578 176 LALMNLFGIELSLATVAALLMLIGYSVDsDI 206
PRK12911 PRK12911
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
 133-280 6.60e-07

bifunctional preprotein translocase subunit SecD/SecF; Reviewed


Pssm-ID: 171815 [Multi-domain]  Cd Length: 1403  Bit Score: 51.01  E-value: 6.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697  133 EFVGPQVGKDLVMNGIYaTLFMVIGFLIYIAARFeWKFA-MVASLTAFFDLILTVAYMSLLGREFDLTVLAGMLSVMGFA 211
Cdd:PRK12911  897 EVISPELGKSQRTQGII-SVCLGLAVLIVLMSVY-YRFGgVIASGAVLLNLLLIWAALQYLDAPLTLSGLAGIVLAMGMA 974

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697  212 INDIIVVFDRVRENFrslrvepleVLNRSINQTLSR-----------TVITAVLffLSALALYLYGGeSMEGLAETHMVG 280
Cdd:PRK12911  975 VDANVLVFERIREEY---------LLSRSLSESVEAgykkafsaifdSNLTTIL--ASALLLMLDTG-PIKGFALTLIIG 1042
PRK13024 PRK13024
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
 133-280 1.34e-06

bifunctional preprotein translocase subunit SecD/SecF; Reviewed


Pssm-ID: 237276 [Multi-domain]  Cd Length: 755  Bit Score: 49.84  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697 133 EFVGPQVGKDLVMNGIYATLFMVIGFLIYIAArFEWKFAMVASLTAFFDLILTVAYMSLLGREFDLTVLAGMLSVMGFAI 212
Cdd:PRK13024 254 RSVGPTLGQDAIDAGIIAGIIGFALIFLFMLV-YYGLPGLIANIALLLYIFLTLGALSSLGAVLTLPGIAGLVLGIGMAV 332

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 948287697 213 NDIIVVFDRVRENFRSlRVEPLEVLNRSINQTLSrTV----ITAVlffLSALALYLYGGESMEGLAETHMVG 280
Cdd:PRK13024 333 DANVLIFERIKEELRK-GKSLKKAFKKGFKNAFS-TIldsnITTL---IAAAILFFFGTGPVKGFATTLIIG 399
PRK13023 PRK13023
protein translocase subunit SecDF;
135-280 5.15e-06

protein translocase subunit SecDF;


Pssm-ID: 171842 [Multi-domain]  Cd Length: 758  Bit Score: 48.08  E-value: 5.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697 135 VGPQVGKDLVMNGIYATLF--MVIGFLIYIAARFEWKFAMVASLTaffDLILTVAYMSLLGREFDLTVLAGMLSVMGFAI 212
Cdd:PRK13023 268 IASALGEDYASAAVLAALLaaLVVGLFMVLSYGILGVIALVALVV---NIIILTAVLSLIGASISLASIAGLVLTIGLAV 344

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 948287697 213 NDIIVVFDRVRENFRSlRVEPLEVLNRSINQTLSRTVITAVLFFLSALALYLYGGESMEGLAETHMVG 280
Cdd:PRK13023 345 DAHILIYERVREDRRK-GYSVVQAMESGFYRALSTIVDANLTTLIAALVLFLLGSGTVHGFALTVAIG 411
Sec_GG pfam07549
SecD/SecF GG Motif; This family consists of various prokaryotic SecD and SecF protein export ...
 38-64 1.72e-04

SecD/SecF GG Motif; This family consists of various prokaryotic SecD and SecF protein export membrane proteins. This SecD and SecF proteins are part of the multimeric protein export complex comprising SecA, D, E, F, G, Y, and YajC. SecD and SecF are required to maintain a proton motive force. This alignment encompasses a -GG- motif typically found in N-terminal half of the SecD/SecF proteins.


Pssm-ID: 462205 [Multi-domain]  Cd Length: 27  Bit Score: 38.04  E-value: 1.72e-04
                          10        20
                  ....*....|....*....|....*..
gi 948287697   38 IIGFKGFNYALEFTGGTVVRTHFEKSV 64
Cdd:pfam07549   1 SLFTRGLNLGLDFTGGTVIELQFDQPV 27
RND_1 NF037998
protein translocase SecDF, variant type; Members of this family are identified by TCDB as ...
 149-235 4.23e-04

protein translocase SecDF, variant type; Members of this family are identified by TCDB as belonging to 2.A.6.4.4, a variant 12-TM type SecDF, as found in Spiroplasma, Mesoplasma, and Acholeplasma.


Pssm-ID: 468306  Cd Length: 1237  Bit Score: 42.07  E-value: 4.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948287697  149 YATLFMVIGFLIYIAARFEWKFAMVASLTAFFDLILTVAYMSLLGREFDLTVLAGMLSVMGFAINDIIVVFDRVRENFRS 228
Cdd:NF037998  961 ISFAIILLALIVYILIRFKWTYYVALALAIVFAPAITVSIVIIFRVPITFEILIAFVSIIGFAIASAIIILGKAKSLISS 1040


                  ....*..
gi 948287697  229 LRVEPLE 235
Cdd:NF037998 1041 KNKKELE 1047
secD PRK08343
preprotein translocase subunit SecD; Reviewed
 40-87 2.37e-03

preprotein translocase subunit SecD; Reviewed


Pssm-ID: 236245 [Multi-domain]  Cd Length: 417  Bit Score: 39.47  E-value: 2.37e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 948287697  40 GFKGFNYALEFTGGTVVRTHFEKSVD-------VEAVRERLATAGFENAQVQSVG 87
Cdd:PRK08343  36 GFTNLQYGLDLSGGSWIQLKLEGPVTqetmdlvVEILESRLNALGLKDIKVYPVG 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH