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Conserved domains on  [gi|949496162|ref|WP_056938708|]
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phosphopyruvate hydratase [Lentilactobacillus buchneri]

Protein Classification

phosphopyruvate hydratase( domain architecture ID 11414960)

phosphopyruvate hydratase (enolase) catalyzes the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways

CATH:  3.20.20.120|3.30.390.10
EC:  4.2.1.11
Gene Ontology:  GO:0004634|GO:0000015|GO:0006096|GO:0000287
PubMed:  8994873|8605183
SCOP:  3001064|3000476

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 1-428 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


:

Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 868.57  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162   1 MSIISDIYAREVLDSRGNPTVEVELYTEAGAMGRGIVPSGASTGEHEAVELRDGDKDRYMGKGVTKAVDNVNNIIAKEIV 80
Cdd:COG0148    1 MSRIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162  81 GYDVTDQLAIDKAMIELDGTPNKGKLGANAILGVSLAAARAAADELEVPLYNYLGGFNGHLLPTPMLNVINGGKHANNKV 160
Cdd:COG0148   81 GMDATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAKTLPVPMMNIINGGAHADNNV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 161 DFQEFMIMPIGAPTIKEAIRWSSETFHNLKNLLNERGYSTAVGDEGGFAPDLKNNEEPFEILVEAIQRAGYKPGKDIAIA 240
Cdd:COG0148  161 DIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGEDIALA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 241 FDCAASEFYntDTKKYDLKGDGKSYTADEFVTLLESIVDKYPVISIEDPLDENEWADWQMATKRLGKKVQIVGDDLFVTN 320
Cdd:COG0148  241 LDVAASEFY--KDGKYHLKGEGKELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDLFVTN 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 321 TDYLKKGINMGVANAILIKLNQIGTLTETVEAVEMAKEAGYTAIISHRSGETEDTTIADLVVGLNAGQIKTGSMSRGERI 400
Cdd:COG0148  319 PKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSRSERV 398

                        410       420
                 ....*....|....*....|....*...
gi 949496162 401 AKYNQLMRIEDQLGDVADYKGIHSFYNL 428
Cdd:COG0148  399 AKYNQLLRIEEELGDAARYAGRSAFKRL 426
 
Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 1-428 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 868.57  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162   1 MSIISDIYAREVLDSRGNPTVEVELYTEAGAMGRGIVPSGASTGEHEAVELRDGDKDRYMGKGVTKAVDNVNNIIAKEIV 80
Cdd:COG0148    1 MSRIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162  81 GYDVTDQLAIDKAMIELDGTPNKGKLGANAILGVSLAAARAAADELEVPLYNYLGGFNGHLLPTPMLNVINGGKHANNKV 160
Cdd:COG0148   81 GMDATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAKTLPVPMMNIINGGAHADNNV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 161 DFQEFMIMPIGAPTIKEAIRWSSETFHNLKNLLNERGYSTAVGDEGGFAPDLKNNEEPFEILVEAIQRAGYKPGKDIAIA 240
Cdd:COG0148  161 DIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGEDIALA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 241 FDCAASEFYntDTKKYDLKGDGKSYTADEFVTLLESIVDKYPVISIEDPLDENEWADWQMATKRLGKKVQIVGDDLFVTN 320
Cdd:COG0148  241 LDVAASEFY--KDGKYHLKGEGKELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDLFVTN 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 321 TDYLKKGINMGVANAILIKLNQIGTLTETVEAVEMAKEAGYTAIISHRSGETEDTTIADLVVGLNAGQIKTGSMSRGERI 400
Cdd:COG0148  319 PKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSRSERV 398

                        410       420
                 ....*....|....*....|....*...
gi 949496162 401 AKYNQLMRIEDQLGDVADYKGIHSFYNL 428
Cdd:COG0148  399 AKYNQLLRIEEELGDAARYAGRSAFKRL 426
eno PRK00077
enolase; Provisional
 1-429 0e+00

enolase; Provisional


Pssm-ID: 234617 [Multi-domain]  Cd Length: 425  Bit Score: 837.05  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162   1 MSIISDIYAREVLDSRGNPTVEVELYTEAGAMGRGIVPSGASTGEHEAVELRDGDKDRYMGKGVTKAVDNVNNIIAKEIV 80
Cdd:PRK00077   1 MSKIEDIIAREILDSRGNPTVEVEVTLEDGAFGRAAVPSGASTGEREAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162  81 GYDVTDQLAIDKAMIELDGTPNKGKLGANAILGVSLAAARAAADELEVPLYNYLGGFNGHLLPTPMLNVINGGKHANNKV 160
Cdd:PRK00077  81 GLDALDQRAIDKAMIELDGTPNKSKLGANAILGVSLAVAKAAADSLGLPLYRYLGGPNAKVLPVPMMNIINGGAHADNNV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 161 DFQEFMIMPIGAPTIKEAIRWSSETFHNLKNLLNERGYSTAVGDEGGFAPDLKNNEEPFEILVEAIQRAGYKPGKDIAIA 240
Cdd:PRK00077 161 DIQEFMIMPVGAPSFKEALRMGAEVFHTLKKVLKEKGLSTAVGDEGGFAPNLKSNEEALDLILEAIEKAGYKPGEDIALA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 241 FDCAASEFYntDTKKYDLKGDGKsyTADEFVTLLESIVDKYPVISIEDPLDENEWADWQMATKRLGKKVQIVGDDLFVTN 320
Cdd:PRK00077 241 LDCAASEFY--KDGKYVLEGEGL--TSEEMIDYLAELVDKYPIVSIEDGLDENDWEGWKLLTEKLGDKVQLVGDDLFVTN 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 321 TDYLKKGINMGVANAILIKLNQIGTLTETVEAVEMAKEAGYTAIISHRSGETEDTTIADLVVGLNAGQIKTGSMSRGERI 400
Cdd:PRK00077 317 TKRLKKGIEKGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVVSHRSGETEDTTIADLAVATNAGQIKTGSLSRSERI 396

                        410       420
                 ....*....|....*....|....*....
gi 949496162 401 AKYNQLMRIEDQLGDVADYKGIHSFYNLS 429
Cdd:PRK00077 397 AKYNQLLRIEEELGDAARYAGKKAFKNLK 425
eno TIGR01060
phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis ...
 4-428 0e+00

phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213580 [Multi-domain]  Cd Length: 425  Bit Score: 747.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162    4 ISDIYAREVLDSRGNPTVEVELYTEAGAMGRGIVPSGASTGEHEAVELRDGDKDRYMGKGVTKAVDNVNNIIAKEIVGYD 83
Cdd:TIGR01060   1 IVDIRAREILDSRGNPTVEVEVILEDGTFGRAAVPSGASTGEREALELRDGDKKRYLGKGVLKAVENVNEIIAPELIGMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162   84 VTDQLAIDKAMIELDGTPNKGKLGANAILGVSLAAARAAADELEVPLYNYLGGFNGHLLPTPMLNVINGGKHANNKVDFQ 163
Cdd:TIGR01060  81 ATDQREIDQILIELDGTPNKSKLGANAILGVSMAVAKAAADSLGLPLYRYLGGFNAYVLPVPMMNIINGGAHADNNLDFQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162  164 EFMIMPIGAPTIKEAIRWSSETFHNLKNLLNERGYSTAVGDEGGFAPDLKNNEEPFEILVEAIQRAGYKPGKDIAIAFDC 243
Cdd:TIGR01060 161 EFMIMPVGAPSFREALRMGAEVFHALKKLLKEKGLATGVGDEGGFAPNLASNEEALEIIVEAIEKAGYKPGEDVALALDC 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162  244 AASEFYNTDTKKYDLKGDGKSYTADEFVTLLESIVDKYPVISIEDPLDENEWADWQMATKRLGKKVQIVGDDLFVTNTDY 323
Cdd:TIGR01060 241 AASEFYDEEDGKYVYKGENKQLTSEEMIEYYEELVEKYPIISIEDGLSEEDWEGWAELTKRLGDKVQIVGDDLFVTNTEI 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162  324 LKKGINMGVANAILIKLNQIGTLTETVEAVEMAKEAGYTAIISHRSGETEDTTIADLVVGLNAGQIKTGSMSRGERIAKY 403
Cdd:TIGR01060 321 LREGIEMGVANSILIKPNQIGTLTETLDAIELAKKAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSLSRSERIAKY 400

                         410       420
                  ....*....|....*....|....*
gi 949496162  404 NQLMRIEDQLGDVADYKGIHSFYNL 428
Cdd:TIGR01060 401 NQLLRIEEELGDSARYAGKNSFYRF 425
enolase cd03313
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of ...
 6-412 0e+00

Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.


Pssm-ID: 239429 [Multi-domain]  Cd Length: 408  Bit Score: 745.07  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162   6 DIYAREVLDSRGNPTVEVELYTEAGAMGRGIVPSGASTGEHEAVELRDGDKDRYMGKGVTKAVDNVNNIIAKEIVGYDVT 85
Cdd:cd03313    1 KIKAREILDSRGNPTVEVEVTTEDGGVGRAAVPSGASTGEHEAVELRDGDKSRYLGKGVLKAVKNVNEIIAPALIGMDVT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162  86 DQLAIDKAMIELDGTPNKGKLGANAILGVSLAAARAAADELEVPLYNYLGGFNGHLLPTPMLNVINGGKHANNKVDFQEF 165
Cdd:cd03313   81 DQRAIDKLLIELDGTPNKSKLGANAILGVSLAVAKAAAAALGLPLYRYLGGLAAYVLPVPMFNVINGGAHAGNKLDFQEF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 166 MIMPIGAPTIKEAIRWSSETFHNLKNLLNERG--YSTAVGDEGGFAPDLKNNEEPFEILVEAIQRAGYKPGKDIAIAFDC 243
Cdd:cd03313  161 MIVPVGAPSFSEALRMGAEVYHTLKKVLKKKGglLATNVGDEGGFAPNLSSNEEALDLLVEAIEKAGYEPGKKIAIALDV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 244 AASEFYNTDTKKYDlKGDGKSYTADEFVTLLESIVDKYPVISIEDPLDENEWADWQMATKRLGKKVQIVGDDLFVTNTDY 323
Cdd:cd03313  241 AASEFYDEGKYVYD-SDEGKKLTSEELIDYYKELVKKYPIVSIEDPFDEDDWEGWAKLTAKLGDKIQIVGDDLFVTNPER 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 324 LKKGINMGVANAILIKLNQIGTLTETVEAVEMAKEAGYTAIISHRSGETEDTTIADLVVGLNAGQIKTGSMSRGERIAKY 403
Cdd:cd03313  320 LKKGIEKKAANALLIKVNQIGTLTETIEAIKLAKKNGYGVVVSHRSGETEDTFIADLAVALGAGQIKTGAPCRSERTAKY 399


                 ....*....
gi 949496162 404 NQLMRIEDQ 412
Cdd:cd03313  400 NQLLRIEEE 408
Enolase_C pfam00113
Enolase, C-terminal TIM barrel domain;
140-428 1.35e-153

Enolase, C-terminal TIM barrel domain;


Pssm-ID: 395063  Cd Length: 296  Bit Score: 436.91  E-value: 1.35e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162  140 HLLPTPMLNVINGGKHANNKVDFQEFMIMPIGAPTIKEAIRWSSETFHNLKNLLNERGYS--TAVGDEGGFAPDLKNNEE 217
Cdd:pfam00113   2 YVLPVPMMNVINGGSHAGNNLAFQEFMILPTGAPSFSEAMRMGAEVYHHLKSVLKAKYGQsaTNVGDEGGFAPNLQSNKE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162  218 PFEILVEAIQRAGYKPgkDIAIAFDCAASEFYNTDTKKYDLKGDG------KSYTADEFVTLLESIVDKYPVISIEDPLD 291
Cdd:pfam00113  82 ALDLIVEAIEKAGYKG--KIKIAMDVASSEFYNKKDGKYDLDFKGeksdksKKLTSAQLADLYEELVKKYPIVSIEDPFD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162  292 ENEWADWQMATKRLGKKVQIVGDDLFVTNTDYLKKGINMGVANAILIKLNQIGTLTETVEAVEMAKEAGYTAIISHRSGE 371
Cdd:pfam00113 160 EDDWEAWKYLTERLGDKVQIVGDDLTVTNPKRLKTAIEKKIANALLLKVNQIGSLTESIAAVKMAKDAGWGVMVSHRSGE 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 949496162  372 TEDTTIADLVVGLNAGQIKTGSMSRGERIAKYNQLMRIEDQLGDVADYKGIHSFYNL 428
Cdd:pfam00113 240 TEDTTIADLAVGLNAGQIKTGAPCRSERLAKYNQLLRIEEELGSEAKYAGRSFRKPL 296
 
Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 1-428 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 868.57  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162   1 MSIISDIYAREVLDSRGNPTVEVELYTEAGAMGRGIVPSGASTGEHEAVELRDGDKDRYMGKGVTKAVDNVNNIIAKEIV 80
Cdd:COG0148    1 MSRIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162  81 GYDVTDQLAIDKAMIELDGTPNKGKLGANAILGVSLAAARAAADELEVPLYNYLGGFNGHLLPTPMLNVINGGKHANNKV 160
Cdd:COG0148   81 GMDATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAKTLPVPMMNIINGGAHADNNV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 161 DFQEFMIMPIGAPTIKEAIRWSSETFHNLKNLLNERGYSTAVGDEGGFAPDLKNNEEPFEILVEAIQRAGYKPGKDIAIA 240
Cdd:COG0148  161 DIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGEDIALA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 241 FDCAASEFYntDTKKYDLKGDGKSYTADEFVTLLESIVDKYPVISIEDPLDENEWADWQMATKRLGKKVQIVGDDLFVTN 320
Cdd:COG0148  241 LDVAASEFY--KDGKYHLKGEGKELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDLFVTN 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 321 TDYLKKGINMGVANAILIKLNQIGTLTETVEAVEMAKEAGYTAIISHRSGETEDTTIADLVVGLNAGQIKTGSMSRGERI 400
Cdd:COG0148  319 PKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSRSERV 398

                        410       420
                 ....*....|....*....|....*...
gi 949496162 401 AKYNQLMRIEDQLGDVADYKGIHSFYNL 428
Cdd:COG0148  399 AKYNQLLRIEEELGDAARYAGRSAFKRL 426
eno PRK00077
enolase; Provisional
 1-429 0e+00

enolase; Provisional


Pssm-ID: 234617 [Multi-domain]  Cd Length: 425  Bit Score: 837.05  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162   1 MSIISDIYAREVLDSRGNPTVEVELYTEAGAMGRGIVPSGASTGEHEAVELRDGDKDRYMGKGVTKAVDNVNNIIAKEIV 80
Cdd:PRK00077   1 MSKIEDIIAREILDSRGNPTVEVEVTLEDGAFGRAAVPSGASTGEREAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162  81 GYDVTDQLAIDKAMIELDGTPNKGKLGANAILGVSLAAARAAADELEVPLYNYLGGFNGHLLPTPMLNVINGGKHANNKV 160
Cdd:PRK00077  81 GLDALDQRAIDKAMIELDGTPNKSKLGANAILGVSLAVAKAAADSLGLPLYRYLGGPNAKVLPVPMMNIINGGAHADNNV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 161 DFQEFMIMPIGAPTIKEAIRWSSETFHNLKNLLNERGYSTAVGDEGGFAPDLKNNEEPFEILVEAIQRAGYKPGKDIAIA 240
Cdd:PRK00077 161 DIQEFMIMPVGAPSFKEALRMGAEVFHTLKKVLKEKGLSTAVGDEGGFAPNLKSNEEALDLILEAIEKAGYKPGEDIALA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 241 FDCAASEFYntDTKKYDLKGDGKsyTADEFVTLLESIVDKYPVISIEDPLDENEWADWQMATKRLGKKVQIVGDDLFVTN 320
Cdd:PRK00077 241 LDCAASEFY--KDGKYVLEGEGL--TSEEMIDYLAELVDKYPIVSIEDGLDENDWEGWKLLTEKLGDKVQLVGDDLFVTN 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 321 TDYLKKGINMGVANAILIKLNQIGTLTETVEAVEMAKEAGYTAIISHRSGETEDTTIADLVVGLNAGQIKTGSMSRGERI 400
Cdd:PRK00077 317 TKRLKKGIEKGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVVSHRSGETEDTTIADLAVATNAGQIKTGSLSRSERI 396

                        410       420
                 ....*....|....*....|....*....
gi 949496162 401 AKYNQLMRIEDQLGDVADYKGIHSFYNLS 429
Cdd:PRK00077 397 AKYNQLLRIEEELGDAARYAGKKAFKNLK 425
eno TIGR01060
phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis ...
 4-428 0e+00

phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213580 [Multi-domain]  Cd Length: 425  Bit Score: 747.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162    4 ISDIYAREVLDSRGNPTVEVELYTEAGAMGRGIVPSGASTGEHEAVELRDGDKDRYMGKGVTKAVDNVNNIIAKEIVGYD 83
Cdd:TIGR01060   1 IVDIRAREILDSRGNPTVEVEVILEDGTFGRAAVPSGASTGEREALELRDGDKKRYLGKGVLKAVENVNEIIAPELIGMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162   84 VTDQLAIDKAMIELDGTPNKGKLGANAILGVSLAAARAAADELEVPLYNYLGGFNGHLLPTPMLNVINGGKHANNKVDFQ 163
Cdd:TIGR01060  81 ATDQREIDQILIELDGTPNKSKLGANAILGVSMAVAKAAADSLGLPLYRYLGGFNAYVLPVPMMNIINGGAHADNNLDFQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162  164 EFMIMPIGAPTIKEAIRWSSETFHNLKNLLNERGYSTAVGDEGGFAPDLKNNEEPFEILVEAIQRAGYKPGKDIAIAFDC 243
Cdd:TIGR01060 161 EFMIMPVGAPSFREALRMGAEVFHALKKLLKEKGLATGVGDEGGFAPNLASNEEALEIIVEAIEKAGYKPGEDVALALDC 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162  244 AASEFYNTDTKKYDLKGDGKSYTADEFVTLLESIVDKYPVISIEDPLDENEWADWQMATKRLGKKVQIVGDDLFVTNTDY 323
Cdd:TIGR01060 241 AASEFYDEEDGKYVYKGENKQLTSEEMIEYYEELVEKYPIISIEDGLSEEDWEGWAELTKRLGDKVQIVGDDLFVTNTEI 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162  324 LKKGINMGVANAILIKLNQIGTLTETVEAVEMAKEAGYTAIISHRSGETEDTTIADLVVGLNAGQIKTGSMSRGERIAKY 403
Cdd:TIGR01060 321 LREGIEMGVANSILIKPNQIGTLTETLDAIELAKKAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSLSRSERIAKY 400

                         410       420
                  ....*....|....*....|....*
gi 949496162  404 NQLMRIEDQLGDVADYKGIHSFYNL 428
Cdd:TIGR01060 401 NQLLRIEEELGDSARYAGKNSFYRF 425
enolase cd03313
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of ...
 6-412 0e+00

Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.


Pssm-ID: 239429 [Multi-domain]  Cd Length: 408  Bit Score: 745.07  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162   6 DIYAREVLDSRGNPTVEVELYTEAGAMGRGIVPSGASTGEHEAVELRDGDKDRYMGKGVTKAVDNVNNIIAKEIVGYDVT 85
Cdd:cd03313    1 KIKAREILDSRGNPTVEVEVTTEDGGVGRAAVPSGASTGEHEAVELRDGDKSRYLGKGVLKAVKNVNEIIAPALIGMDVT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162  86 DQLAIDKAMIELDGTPNKGKLGANAILGVSLAAARAAADELEVPLYNYLGGFNGHLLPTPMLNVINGGKHANNKVDFQEF 165
Cdd:cd03313   81 DQRAIDKLLIELDGTPNKSKLGANAILGVSLAVAKAAAAALGLPLYRYLGGLAAYVLPVPMFNVINGGAHAGNKLDFQEF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 166 MIMPIGAPTIKEAIRWSSETFHNLKNLLNERG--YSTAVGDEGGFAPDLKNNEEPFEILVEAIQRAGYKPGKDIAIAFDC 243
Cdd:cd03313  161 MIVPVGAPSFSEALRMGAEVYHTLKKVLKKKGglLATNVGDEGGFAPNLSSNEEALDLLVEAIEKAGYEPGKKIAIALDV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 244 AASEFYNTDTKKYDlKGDGKSYTADEFVTLLESIVDKYPVISIEDPLDENEWADWQMATKRLGKKVQIVGDDLFVTNTDY 323
Cdd:cd03313  241 AASEFYDEGKYVYD-SDEGKKLTSEELIDYYKELVKKYPIVSIEDPFDEDDWEGWAKLTAKLGDKIQIVGDDLFVTNPER 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 324 LKKGINMGVANAILIKLNQIGTLTETVEAVEMAKEAGYTAIISHRSGETEDTTIADLVVGLNAGQIKTGSMSRGERIAKY 403
Cdd:cd03313  320 LKKGIEKKAANALLIKVNQIGTLTETIEAIKLAKKNGYGVVVSHRSGETEDTFIADLAVALGAGQIKTGAPCRSERTAKY 399


                 ....*....
gi 949496162 404 NQLMRIEDQ 412
Cdd:cd03313  400 NQLLRIEEE 408
PTZ00081 PTZ00081
enolase; Provisional
 1-421 0e+00

enolase; Provisional


Pssm-ID: 240259 [Multi-domain]  Cd Length: 439  Bit Score: 592.79  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162   1 MSIISDIYAREVLDSRGNPTVEVELYTEAGAMgRGIVPSGASTGEHEAVELRDGDKDRYMGKGVTKAVDNVNNIIAKEIV 80
Cdd:PTZ00081   1 MSTIKSIKAREILDSRGNPTVEVDLTTEKGVF-RAAVPSGASTGIYEALELRDGDKSRYLGKGVLKAVENVNEIIAPALI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162  81 GYDVTDQLAIDKAMIE-LDGTPN-----KGKLGANAILGVSLAAARAAADELEVPLYNYLGGFNGH-----LLPTPMLNV 149
Cdd:PTZ00081  80 GKDVTDQKKLDKLMVEqLDGTKNewgwcKSKLGANAILAVSMAVARAAAAAKGVPLYKYLAQLAGKptdkfVLPVPCFNV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 150 INGGKHANNKVDFQEFMIMPIGAPTIKEAIRWSSETFHNLKNLLNERgY---STAVGDEGGFAPDLKNNEEPFEILVEAI 226
Cdd:PTZ00081 160 INGGKHAGNKLAFQEFMIAPVGAPSFKEALRMGAEVYHSLKSVIKKK-YgldATNVGDEGGFAPNIKDPEEALDLLVEAI 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 227 QRAGYKpGKdIAIAFDCAASEFYNTDTKKYDL-----KGDGKSY-TADEFVTLLESIVDKYPVISIEDPLDENEWADWQM 300
Cdd:PTZ00081 239 KKAGYE-GK-VKICMDVAASEFYDKEKKVYDLdfknpNNDKSNKlTGEELVELYLDLVKKYPIVSIEDPFDQDDWEAYAK 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 301 ATKRLGKKVQIVGDDLFVTNTDYLKKGINMGVANAILIKLNQIGTLTETVEAVEMAKEAGYTAIISHRSGETEDTTIADL 380
Cdd:PTZ00081 317 LTAAIGQKVQIVGDDLLVTNPTRIKKAIEKKACNALLLKVNQIGTVTEAIEAAKLAQKNGWGVMVSHRSGETEDTFIADL 396

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 949496162 381 VVGLNAGQIKTGSMSRGERIAKYNQLMRIEDQLGDVADYKG 421
Cdd:PTZ00081 397 VVGLGTGQIKTGAPCRSERLAKYNQLLRIEEELGSNAVYAG 437
PLN00191 PLN00191
enolase
 1-421 0e+00

enolase


Pssm-ID: 215095 [Multi-domain]  Cd Length: 457  Bit Score: 547.38  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162   1 MSIISDIYAREVLDSRGNPTVEVELYTEAGaMGRGIVPSGASTGEHEAVELRDGDKDrYMGKGVTKAVDNVNNIIAKEIV 80
Cdd:PLN00191  25 MATITKVKARQIIDSRGNPTVEVDLHTSKG-MFRAAVPSGASTGIYEALELRDGDKD-YLGKGVLKAVKNVNEIIAPALI 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162  81 GYDVTDQLAIDKAMIELDGTPNKGKLGANAILGVSLAAARAAADELEVPLYNY---LGGFNGHLLPTPMLNVINGGKHAN 157
Cdd:PLN00191 103 GMDPTDQTQIDNFMLELDGTPNKGKLGANAILAVSLAVCKAGAAEKGVPLYKHiadLAGNKKLVLPVPAFNVINGGSHAG 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 158 NKVDFQEFMIMPIGAPTIKEAIRWSSETFHNLKNLLNER--GYSTAVGDEGGFAPDLKNNEEPFEILVEAIQRAGYKpGK 235
Cdd:PLN00191 183 NKLAMQEFMILPVGASSFKEAMQMGSEVYHHLKAVIKKKygQDACNVGDEGGFAPNIQDNKEGLELLKEAIEKAGYT-GK 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 236 dIAIAFDCAASEFYNTDtKKYDL--KGDGKS----YTADEFVTLLESIVDKYPVISIEDPLDENEWADWQMATKRlgKKV 309
Cdd:PLN00191 262 -IKIGMDVAASEFYTKD-KKYDLdfKEENNDgsnkKSGDELIDLYKEFVSDYPIVSIEDPFDQDDWEHWAKLTSL--EDV 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 310 QIVGDDLFVTNTDYLKKGINMGVANAILIKLNQIGTLTETVEAVEMAKEAGYTAIISHRSGETEDTTIADLVVGLNAGQI 389
Cdd:PLN00191 338 QIVGDDLLVTNPKRVAKAIQEKACNALLLKVNQIGTVTESIEAVKMSKAAGWGVMTSHRSGETEDSFIADLAVGLATGQI 417

                        410       420       430
                 ....*....|....*....|....*....|..
gi 949496162 390 KTGSMSRGERIAKYNQLMRIEDQLGDVADYKG 421
Cdd:PLN00191 418 KTGAPCRSERLAKYNQLLRIEEELGDEAVYAG 449
Enolase_C pfam00113
Enolase, C-terminal TIM barrel domain;
140-428 1.35e-153

Enolase, C-terminal TIM barrel domain;


Pssm-ID: 395063  Cd Length: 296  Bit Score: 436.91  E-value: 1.35e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162  140 HLLPTPMLNVINGGKHANNKVDFQEFMIMPIGAPTIKEAIRWSSETFHNLKNLLNERGYS--TAVGDEGGFAPDLKNNEE 217
Cdd:pfam00113   2 YVLPVPMMNVINGGSHAGNNLAFQEFMILPTGAPSFSEAMRMGAEVYHHLKSVLKAKYGQsaTNVGDEGGFAPNLQSNKE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162  218 PFEILVEAIQRAGYKPgkDIAIAFDCAASEFYNTDTKKYDLKGDG------KSYTADEFVTLLESIVDKYPVISIEDPLD 291
Cdd:pfam00113  82 ALDLIVEAIEKAGYKG--KIKIAMDVASSEFYNKKDGKYDLDFKGeksdksKKLTSAQLADLYEELVKKYPIVSIEDPFD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162  292 ENEWADWQMATKRLGKKVQIVGDDLFVTNTDYLKKGINMGVANAILIKLNQIGTLTETVEAVEMAKEAGYTAIISHRSGE 371
Cdd:pfam00113 160 EDDWEAWKYLTERLGDKVQIVGDDLTVTNPKRLKTAIEKKIANALLLKVNQIGSLTESIAAVKMAKDAGWGVMVSHRSGE 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 949496162  372 TEDTTIADLVVGLNAGQIKTGSMSRGERIAKYNQLMRIEDQLGDVADYKGIHSFYNL 428
Cdd:pfam00113 240 TEDTTIADLAVGLNAGQIKTGAPCRSERLAKYNQLLRIEEELGSEAKYAGRSFRKPL 296
Enolase_N pfam03952
Enolase, N-terminal domain;
4-134 2.57e-82

Enolase, N-terminal domain;


Pssm-ID: 461105 [Multi-domain]  Cd Length: 131  Bit Score: 249.21  E-value: 2.57e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162    4 ISDIYAREVLDSRGNPTVEVELYTEAGAMGRGIVPSGASTGEHEAVELRDGDKDRYMGKGVTKAVDNVNNIIAKEIVGYD 83
Cdd:pfam03952   1 ITKVKAREILDSRGNPTVEVEVTLEDGTFGRAAVPSGASTGEHEAVELRDGDKSRYGGKGVLKAVENVNEIIAPALIGMD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 949496162   84 VTDQLAIDKAMIELDGTPNKGKLGANAILGVSLAAARAAADELEVPLYNYL 134
Cdd:pfam03952  81 ATDQRAIDRALIELDGTENKSKLGANAILGVSLAVAKAAAAALGLPLYRYL 131
PRK08350 PRK08350
hypothetical protein; Provisional
 1-415 1.81e-16

hypothetical protein; Provisional


Pssm-ID: 169397 [Multi-domain]  Cd Length: 341  Bit Score: 80.23  E-value: 1.81e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162   1 MSIISDIYAREVLDSRGNPTVEVELYTEAGaMGRGIVPSgastgeheavelrDGDKDRYMGKGvTKAVDNVNNIIAKEIV 80
Cdd:PRK08350   1 MTVIENIIGRVAVLRGGKYSVEVDVITDSG-FGRFAAPI-------------DENPSLYIAEA-HRAVSEVDEIIGPELI 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162  81 GYDVTDQLAIDKAMIELDGTPNKGKLGANAILGVSLAAARAAADELEVPLYNYLGGFNGHLLPTPMLNVINGgkhannkv 160
Cdd:PRK08350  66 GFDASEQELIDSYLWEIDGTEDFSHIGANTALAVSVAVAKAAANSKNMPLYSYIGGTFTTELPVPILEFAED-------- 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 161 DFQEFMIMpigaptikeairwssetfhnLKNLLNERGYSTAVGdeggfapdlKNNEEPFEILVEAIQRAGYKPGKDIAIA 240
Cdd:PRK08350 138 ENFEYYVL--------------------VRDLMEITDVVDAVN---------KILENSKEVSLEGLSKASEKAGDELGLE 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 241 FDCAASEFYNTDTKKydlkgdgksytadefvtlLESIVDKYPVISIEDPLDENEWADWQMATkrlgKKVQIVGDDLFVTN 320
Cdd:PRK08350 189 VALGIAQKREMETEK------------------VLNLVEDNNIAYIKPIGDEELFLELIAGT----HGVFIDGEYLFRTR 246

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 321 TDYLKKginmgVANAILIKLNQIGTLTETVEAVEMAKEAGYTAIISHRSGETEDTTIADLVVGLNAGQIktgsMSRGERI 400
Cdd:PRK08350 247 NILDRR-----YYNALSIKPINLGTLTDLYNLVNDVKSERITPILAEAKYESADEALPHLAVGLRCPAM----LIHKDSV 317

                        410
                 ....*....|....*
gi 949496162 401 AKYNQLMRIEDQLGD 415
Cdd:PRK08350 318 EKINELNRIAEDLGE 332
enolase_like cd00308
Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is ...
 215-391 7.12e-12

Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion. Enolase superfamily contains different enzymes, like enolases, glutarate-, fucanate- and galactonate dehydratases, o-succinylbenzoate synthase, N-acylamino acid racemase, L-alanine-DL-glutamate epimerase, mandelate racemase, muconate lactonizing enzyme and 3-methylaspartase.


Pssm-ID: 238188 [Multi-domain]  Cd Length: 229  Bit Score: 64.66  E-value: 7.12e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 215 NEEPFEILVEAIqragykpGKDIAIAFDCAASEFYNTDtkkYDLkgdGKSytadefvtllesiVDKYPVISIEDPLDENE 294
Cdd:cd00308   80 SIERVRAVREAF-------GPDARLAVDANGAWTPKEA---IRL---IRA-------------LEKYGLAWIEEPCAPDD 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 295 WADWQMATKRLGkkVQIVGDDLFVTNtDYLKKGINMGVANAILIKLNQIGTLTETVEAVEMAKEAGYTAIISHRSG-ETE 373
Cdd:cd00308  134 LEGYAALRRRTG--IPIAADESVTTV-DDALEALELGAVDILQIKPTRVGGLTESRRAADLAEAFGIRVMVHGTLEsSIG 210

                        170
                 ....*....|....*....
gi 949496162 374 DTTIADLVVGL-NAGQIKT 391
Cdd:cd00308  211 TAAALHLAAALpNDRAIET 229
RspA COG4948
L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily [Cell wall/membrane ...
 207-360 9.92e-05

L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily [Cell wall/membrane/envelope biogenesis, General function prediction only]; L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 443975 [Multi-domain]  Cd Length: 359  Bit Score: 44.43  E-value: 9.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 207 GFAPDLKNNEEPFEILVEAIqragykpGKDIAIAFDCaasefyNTdtkkydlkgdgkSYTADEFVTLLESIvDKYPVISI 286
Cdd:COG4948  160 VGGPDPEEDVERVRAVREAV-------GPDARLRVDA------NG------------AWTLEEAIRLLRAL-EDLGLEWI 213

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 949496162 287 EDPLDENEWADWQMATKRLGkkVQIVGDDLFVTNTDyLKKGINMGVANAILIKLNQIGTLTETVEAVEMAKEAG 360
Cdd:COG4948  214 EQPLPAEDLEGLAELRRATP--VPIAADESLTSRAD-FRRLIEAGAVDIVNIKLSKVGGLTEALRIAALAEAHG 284
NAAAR cd03317
N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of ...
 216-360 1.24e-04

N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building blocks for antibiotics, herbicides, and drugs. NAAAR is a member of the enolase superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion.


Pssm-ID: 239433 [Multi-domain]  Cd Length: 354  Bit Score: 43.76  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949496162 216 EEPFEILVEAIQRA---GY-------KPGKDIaiafdcaasEFYNTDTKKY---DLKGDGKS-YTADEFVTLLEsiVDKY 281
Cdd:cd03317  135 QDDVEQLLKQIERYleeGYkriklkiKPGWDV---------EPLKAVRERFpdiPLMADANSaYTLADIPLLKR--LDEY 203

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 949496162 282 PVISIEDPLDENEWADWQMATKRLGKKVQIvgdDLFVTNTDYLKKGINMGVANAILIKLNQIGTLTETVEAVEMAKEAG 360
Cdd:cd03317  204 GLLMIEQPLAADDLIDHAELQKLLKTPICL---DESIQSAEDARKAIELGACKIINIKPGRVGGLTEALKIHDLCQEHG 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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