NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|950270992|ref|WP_057307172|]
View 

LytS/YhcK type 5TM receptor domain-containing protein [Paenibacillus sp. Root444D2]

Protein Classification

LytS family sensor histidine kinase( domain architecture ID 1000382)

LytS family sensor histidine kinase is the histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Streptococcus mutans LytS

EC:  2.7.13.3
Gene Ontology:  GO:0000155|GO:0005524
PubMed:  22937869

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
311-574 1.67e-64

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


:

Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 215.50  E-value: 1.67e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 311 RLLRAAIIVPIKQAGQVAGLIKLYFKKPQEIRSVEIVLAEGLGKLLSYQLSVAMHESMEALMKESELRILQSQINPHFLF 390
Cdd:COG3275   95 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLF 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 391 NTLNSIISLIRIEPDMARHITMQLSTYMRLNIKLIASHTISIQQEIMHLSSYLEIIQIRFKDQITMEVQLDSDLLIAMIP 470
Cdd:COG3275  175 NTLNSIYSLIREDPEKARELLLKLSDLLRYSLYESDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIP 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 471 PVTLQPLVENCIKHGLKDRNHGGRIRIEVLNHKDTLQISIEDNGSGIPPElleqlgnepvNSSEGNGIGVYNVNQRLIGL 550
Cdd:COG3275  255 PLLLQPLVENAIKHGISSKEGGGTISISIEVEGDRLVIEVENNGVGIQPK----------KKKKGSGIGLKNVRERLELL 324

                        250       260
                 ....*....|....*....|....
gi 950270992 551 FGEESRLFIENNVNGGCRFSFNIP 574
Cdd:COG3275  325 YGDKYSLEIESTDGGGTKVTLKIP 348
5TM-5TMR_LYT pfam07694
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ...
 25-205 8.16e-37

5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).


:

Pssm-ID: 429599  Cd Length: 170  Bit Score: 134.62  E-value: 8.16e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992   25 IPIVRQLLD-RKMSVMNTIYFICLFGLFGILGTYAGVVIEGGVIsssfwifplqanqalAHSALVGVVIGGLMGGPIVGI 103
Cdd:pfam07694   1 IPLFRRLLSkRRLRLKDKVLLGLIFGLFSILGTYTGIEIEPGAI---------------ANTRAVGIVLAGLLGGPIVGL 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992  104 GAGLITGSHLYVMSGFTGFAGGIAAPLTGLLAGGVARFF-LQERVISPAKAIFIGMFAPIVQMGIILIVSVPSKIAIELV 182
Cdd:pfam07694  66 IAGLIAGLHRYFLGGFTALACGISTILAGLIAGLLHRRLkRRRRLISPLLAFLIGLIAEILQMLLILLLALPFDLALALV 145

                         170       180
                  ....*....|....*....|...
gi 950270992  183 DLIGIPMVLTNSISIAIFTTMLR 205
Cdd:pfam07694 146 KTIALPMILVNSLGTAIFLSILR 168
GAF_2 pfam13185
GAF domain; The GAF domain is named after some of the proteins it is found in, including ...
 240-365 1.50e-03

GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


:

Pssm-ID: 433019 [Multi-domain]  Cd Length: 137  Bit Score: 38.99  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992  240 QSADAIARLLLRE------HKTAAVAITDTENILAHAGLGDMILI--PGEPIRSELSRQAIGTGKLQIALNHEDIQPNHR 311
Cdd:pfam13185   2 ADLEELLDAVLEAavelgaSAVGFILLVDDDGRLAAWGGAADELSaaLDDPPGEGLVGEALRTGRPVIVNDLAADPAKKG 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992  312 L------LRAAIIVPIKQAGQVAGLIKLYFKKPQEIRSVEIVLAEglgkLLSYQLSVAMH 365
Cdd:pfam13185  82 LpaghagLRSFLSVPLVSGGRVVGVLALGSNRPGAFDEEDLELLE----LLAEQAAIAIE 137
 
Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
311-574 1.67e-64

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 215.50  E-value: 1.67e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 311 RLLRAAIIVPIKQAGQVAGLIKLYFKKPQEIRSVEIVLAEGLGKLLSYQLSVAMHESMEALMKESELRILQSQINPHFLF 390
Cdd:COG3275   95 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLF 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 391 NTLNSIISLIRIEPDMARHITMQLSTYMRLNIKLIASHTISIQQEIMHLSSYLEIIQIRFKDQITMEVQLDSDLLIAMIP 470
Cdd:COG3275  175 NTLNSIYSLIREDPEKARELLLKLSDLLRYSLYESDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIP 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 471 PVTLQPLVENCIKHGLKDRNHGGRIRIEVLNHKDTLQISIEDNGSGIPPElleqlgnepvNSSEGNGIGVYNVNQRLIGL 550
Cdd:COG3275  255 PLLLQPLVENAIKHGISSKEGGGTISISIEVEGDRLVIEVENNGVGIQPK----------KKKKGSGIGLKNVRERLELL 324

                        250       260
                 ....*....|....*....|....
gi 950270992 551 FGEESRLFIENNVNGGCRFSFNIP 574
Cdd:COG3275  325 YGDKYSLEIESTDGGGTKVTLKIP 348
5TM-5TMR_LYT pfam07694
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ...
 25-205 8.16e-37

5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).


Pssm-ID: 429599  Cd Length: 170  Bit Score: 134.62  E-value: 8.16e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992   25 IPIVRQLLD-RKMSVMNTIYFICLFGLFGILGTYAGVVIEGGVIsssfwifplqanqalAHSALVGVVIGGLMGGPIVGI 103
Cdd:pfam07694   1 IPLFRRLLSkRRLRLKDKVLLGLIFGLFSILGTYTGIEIEPGAI---------------ANTRAVGIVLAGLLGGPIVGL 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992  104 GAGLITGSHLYVMSGFTGFAGGIAAPLTGLLAGGVARFF-LQERVISPAKAIFIGMFAPIVQMGIILIVSVPSKIAIELV 182
Cdd:pfam07694  66 IAGLIAGLHRYFLGGFTALACGISTILAGLIAGLLHRRLkRRRRLISPLLAFLIGLIAEILQMLLILLLALPFDLALALV 145

                         170       180
                  ....*....|....*....|...
gi 950270992  183 DLIGIPMVLTNSISIAIFTTMLR 205
Cdd:pfam07694 146 KTIALPMILVNSLGTAIFLSILR 168
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 469-574 6.73e-33

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 121.76  E-value: 6.73e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 469 IPPVTLQPLVENCIKHGLKDRNHGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEQLGNEPVNSSEGNGIGVYNVNQRLI 548
Cdd:cd16957    1 VPPFALQVLVENAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTSEKGTGTALENLNRRLI 80

                         90       100
                 ....*....|....*....|....*.
gi 950270992 549 GLFGEESRLFIENNVNGGCRFSFNIP 574
Cdd:cd16957   81 GLFGSEACLHIESEVHGGTEVWFVIP 106
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 375-454 3.88e-27

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 104.45  E-value: 3.88e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992  375 SELRILQSQINPHFLFNTLNSIISLIRIEPDMARHITMQLSTYMRLNIKLiASHTISIQQEIMHLSSYLEIIQIRFKDQI 454
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLYE-GEELVTLEEELEFLENYLEIQKIRFGDRL 79
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 474-574 1.69e-15

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 72.68  E-value: 1.69e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992   474 LQPLVENCIKHGLKDRNHGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEQL------GNEPVNSSEGNGIGVYNVNQRL 547
Cdd:smart00387   6 LRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIfepffrTDKRSRKIGGTGLGLSIVKKLV 85

                           90       100
                   ....*....|....*....|....*..
gi 950270992   548 IGLFGEesrLFIENNVNGGCRFSFNIP 574
Cdd:smart00387  86 ELHGGE---ISVESEPGGGTTFTITLP 109
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
451-574 3.85e-06

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 49.97  E-value: 3.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 451 KDQITMEVQLDSDLLIAMIPPVTLQPLVENCIKHGLKDRNHGGRIRIEV-LNHKDTLQISIEDNGSGIPPELLEQLgNEP 529
Cdd:PRK11360 478 QARVDFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTwQYSDGQVAVSIEDNGCGIDPELLKKI-FDP 556

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 950270992 530 VNS--SEGNGIGVyNVNQRLIGLFGeeSRLFIENNVNGGCRFSFNIP 574
Cdd:PRK11360 557 FFTtkAKGTGLGL-ALSQRIINAHG--GDIEVESEPGVGTTFTLYLP 600
GAF_2 pfam13185
GAF domain; The GAF domain is named after some of the proteins it is found in, including ...
 240-365 1.50e-03

GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 433019 [Multi-domain]  Cd Length: 137  Bit Score: 38.99  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992  240 QSADAIARLLLRE------HKTAAVAITDTENILAHAGLGDMILI--PGEPIRSELSRQAIGTGKLQIALNHEDIQPNHR 311
Cdd:pfam13185   2 ADLEELLDAVLEAavelgaSAVGFILLVDDDGRLAAWGGAADELSaaLDDPPGEGLVGEALRTGRPVIVNDLAADPAKKG 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992  312 L------LRAAIIVPIKQAGQVAGLIKLYFKKPQEIRSVEIVLAEglgkLLSYQLSVAMH 365
Cdd:pfam13185  82 LpaghagLRSFLSVPLVSGGRVVGVLALGSNRPGAFDEEDLELLE----LLAEQAAIAIE 137
 
Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
311-574 1.67e-64

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 215.50  E-value: 1.67e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 311 RLLRAAIIVPIKQAGQVAGLIKLYFKKPQEIRSVEIVLAEGLGKLLSYQLSVAMHESMEALMKESELRILQSQINPHFLF 390
Cdd:COG3275   95 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLF 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 391 NTLNSIISLIRIEPDMARHITMQLSTYMRLNIKLIASHTISIQQEIMHLSSYLEIIQIRFKDQITMEVQLDSDLLIAMIP 470
Cdd:COG3275  175 NTLNSIYSLIREDPEKARELLLKLSDLLRYSLYESDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIP 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 471 PVTLQPLVENCIKHGLKDRNHGGRIRIEVLNHKDTLQISIEDNGSGIPPElleqlgnepvNSSEGNGIGVYNVNQRLIGL 550
Cdd:COG3275  255 PLLLQPLVENAIKHGISSKEGGGTISISIEVEGDRLVIEVENNGVGIQPK----------KKKKGSGIGLKNVRERLELL 324

                        250       260
                 ....*....|....*....|....
gi 950270992 551 FGEESRLFIENNVNGGCRFSFNIP 574
Cdd:COG3275  325 YGDKYSLEIESTDGGGTKVTLKIP 348
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
312-574 3.32e-62

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 212.19  E-value: 3.32e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 312 LLRAAIIVPIKQ-AGQVAGLIKLYFKKPQEIRSVEI-VLAEGLGKLL-SYQLSVAMHESMEALMKESELRILQSQINPHF 388
Cdd:COG2972  176 LLSRSITRPIKRlKKAMKKVEKGDLVRLEVSGNDEIgILARSFNEMVeRIKELIEEVYELELEKKEAELKALQAQINPHF 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 389 LFNTLNSIISLIRIE-PDMARHITMQLSTYMRLNIKlIASHTISIQQEIMHLSSYLEIIQIRFKDQITMEVQLDSDLLIA 467
Cdd:COG2972  256 LFNTLNSIRWLAELEdPEEAEEMLEALSKLLRYSLS-KGDELVTLEEELELIKSYLEIQKLRFGDRLEVEIEIDEELLDL 334

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 468 MIPPVTLQPLVENCIKHGLKDRNHGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEQLGNEPVNSSEGNGIGVYNVNQRL 547
Cdd:COG2972  335 LIPKLILQPLVENAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGEGRGIGLRNVRERL 414

                        250       260
                 ....*....|....*....|....*..
gi 950270992 548 IGLFGEESRLFIENNVNGGCRFSFNIP 574
Cdd:COG2972  415 KLYYGEEYGLEIESEPGEGTTVTIRIP 441
5TM-5TMR_LYT pfam07694
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ...
 25-205 8.16e-37

5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).


Pssm-ID: 429599  Cd Length: 170  Bit Score: 134.62  E-value: 8.16e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992   25 IPIVRQLLD-RKMSVMNTIYFICLFGLFGILGTYAGVVIEGGVIsssfwifplqanqalAHSALVGVVIGGLMGGPIVGI 103
Cdd:pfam07694   1 IPLFRRLLSkRRLRLKDKVLLGLIFGLFSILGTYTGIEIEPGAI---------------ANTRAVGIVLAGLLGGPIVGL 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992  104 GAGLITGSHLYVMSGFTGFAGGIAAPLTGLLAGGVARFF-LQERVISPAKAIFIGMFAPIVQMGIILIVSVPSKIAIELV 182
Cdd:pfam07694  66 IAGLIAGLHRYFLGGFTALACGISTILAGLIAGLLHRRLkRRRRLISPLLAFLIGLIAEILQMLLILLLALPFDLALALV 145

                         170       180
                  ....*....|....*....|...
gi 950270992  183 DLIGIPMVLTNSISIAIFTTMLR 205
Cdd:pfam07694 146 KTIALPMILVNSLGTAIFLSILR 168
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 469-574 6.73e-33

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 121.76  E-value: 6.73e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 469 IPPVTLQPLVENCIKHGLKDRNHGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEQLGNEPVNSSEGNGIGVYNVNQRLI 548
Cdd:cd16957    1 VPPFALQVLVENAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTSEKGTGTALENLNRRLI 80

                         90       100
                 ....*....|....*....|....*.
gi 950270992 549 GLFGEESRLFIENNVNGGCRFSFNIP 574
Cdd:cd16957   81 GLFGSEACLHIESEVHGGTEVWFVIP 106
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 469-574 2.21e-29

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 111.77  E-value: 2.21e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 469 IPPVTLQPLVENCIKHGLKDRNHGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEQLGNepvNSSEGNGIGVYNVNQRLI 548
Cdd:cd16924    1 IPPFTLQPLVENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGIDPKVLNILGK---KPKEGNGIGLYNVHQRLI 77

                         90       100
                 ....*....|....*....|....*.
gi 950270992 549 GLFGEESRLFIENNVNGGCRFSFNIP 574
Cdd:cd16924   78 LLFGEDYGIHIASEPDKGTRITFTIP 103
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 375-454 3.88e-27

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 104.45  E-value: 3.88e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992  375 SELRILQSQINPHFLFNTLNSIISLIRIEPDMARHITMQLSTYMRLNIKLiASHTISIQQEIMHLSSYLEIIQIRFKDQI 454
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLYE-GEELVTLEEELEFLENYLEIQKIRFGDRL 79
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 469-574 1.70e-19

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 83.64  E-value: 1.70e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 469 IPPVTLQPLVENCIKHGLKDRNHGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEQLGnepvnSSEGNGIGVYNVNQRLI 548
Cdd:cd16956    1 LPFLTLQPIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMDPDTLARIL-----IRSSNGLGLNLVDKRLR 75

                         90       100
                 ....*....|....*....|....*.
gi 950270992 549 GLFGEESRLFIENNVNGGCRFSFNIP 574
Cdd:cd16956   76 QAFGNDYGLDIECAPGEGTRITIRLP 101
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 469-574 2.29e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 77.50  E-value: 2.29e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 469 IPPVTLQPLVENCIKHGLKDRNHGGRIRIEV-LNHKDTLQISIEDNGSGIPPELLEQLgnePVNSSEGNGIGVYNVNQRL 547
Cdd:cd16955    1 IPKLMIQPLVENAIVHGIQEKKGKGVVKISVkKQLKNRLHIAVEDNGIGISPKVIERV---EQDEMPGNKIGLLNVHQRL 77

                         90       100
                 ....*....|....*....|....*..
gi 950270992 548 IGLFGEesRLFIENNVNGGCRFSFNIP 574
Cdd:cd16955   78 KLGYGE--GLHIRSRPDPGTLIAFYIP 102
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 474-574 1.69e-15

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 72.68  E-value: 1.69e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992   474 LQPLVENCIKHGLKDRNHGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEQL------GNEPVNSSEGNGIGVYNVNQRL 547
Cdd:smart00387   6 LRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIfepffrTDKRSRKIGGTGLGLSIVKKLV 85

                           90       100
                   ....*....|....*....|....*..
gi 950270992   548 IGLFGEesrLFIENNVNGGCRFSFNIP 574
Cdd:smart00387  86 ELHGGE---ISVESEPGGGTTFTITLP 109
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
405-574 3.98e-15

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 75.33  E-value: 3.98e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 405 DMARHITMQLSTYMR--LNIKLIASHTISIQQEIMHLSSYLEIIQIRFKD-----QITMEVQLDSDLLIAMIPPVTLQP- 476
Cdd:COG2205   57 EIIRESAERLLRLIEdlLDLSRLESGKLSLELEPVDLAELLEEAVEELRPlaeekGIRLELDLPPELPLVYADPELLEQv 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 477 ---LVENCIKHGlkdrNHGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEQLGN-----EPVNSSEGNGIGVYNVnQRLI 548
Cdd:COG2205  137 lanLLDNAIKYS----PPGGTITISARREGDGVRISVSDNGPGIPEEELERIFErfyrgDNSRGEGGTGLGLAIV-KRIV 211

                        170       180
                 ....*....|....*....|....*.
gi 950270992 549 GLFGeeSRLFIENNVNGGCRFSFNIP 574
Cdd:COG2205  212 EAHG--GTIWVESEPGGGTTFTVTLP 235
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
420-574 1.48e-13

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 71.86  E-value: 1.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 420 LNIKLIASHTISIQQEIMHLSSYLEIIQIRFKDQ-----ITMEVQLDSDLLIAMIPPVTLQP----LVENCIKHGlkdrN 490
Cdd:COG0642  165 LDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLaeekgIELELDLPDDLPTVRGDPDRLRQvllnLLSNAIKYT----P 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 491 HGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEQLGN-----EPVNSSEGNGIGVYnVNQRLIGLFGeeSRLFIENNVNG 565
Cdd:COG0642  241 EGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEpffrtDPSRRGGGTGLGLA-IVKRIVELHG--GTIEVESEPGK 317


                 ....*....
gi 950270992 566 GCRFSFNIP 574
Cdd:COG0642  318 GTTFTVTLP 326
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 471-574 2.43e-13

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 66.62  E-value: 2.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992  471 PVTLQPLVENCIKHGLKDRNHGGRIRIEVlNHKDTLQISIEDNGSGIPPELLEQLG----NEPVNSSEGNGIGVYNVNqR 546
Cdd:pfam02518   3 ELRLRQVLSNLLDNALKHAAKAGEITVTL-SEGGELTLTVEDNGIGIPPEDLPRIFepfsTADKRGGGGTGLGLSIVR-K 80

                          90       100
                  ....*....|....*....|....*...
gi 950270992  547 LIGLFGeeSRLFIENNVNGGCRFSFNIP 574
Cdd:pfam02518  81 LVELLG--GTITVESEPGGGTTVTLTLP 106
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 474-571 4.56e-13

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 65.32  E-value: 4.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 474 LQPLVENCIKHGLKdrnhGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEQLGN-----EPVNSSEGNGIGVYNVnQRLI 548
Cdd:cd00075    5 LSNLLDNALKYSPP----GGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFErfyrgDKSREGGGTGLGLAIV-RRIV 79

                         90       100
                 ....*....|....*....|...
gi 950270992 549 GLFGeeSRLFIENNVNGGCRFSF 571
Cdd:cd00075   80 EAHG--GRITVESEPGGGTTFTV 100
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 377-574 7.12e-11

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 64.05  E-value: 7.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 377 LRILQSQINPHFLFNTLNSIISLIRiepdMARHITMQLSTYMRLNikLIASHTISIQQEImhlSSYLEIIQIRFKDQ-IT 455
Cdd:COG4191  168 RRRLEDEPDPEELREALERILEGAE----RAAEIVRSLRAFSRRD--EEEREPVDLNELI---DEALELLRPRLKARgIE 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 456 MEVQLDSDLLIAMIPPVTLQPLVENCIK---HGLKDRNhGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEQLGnEP--- 529
Cdd:COG4191  239 VELDLPPDLPPVLGDPGQLEQVLLNLLInaiDAMEEGE-GGRITISTRREGDYVVISVRDNGPGIPPEVLERIF-EPfft 316

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 950270992 530 ---VnsSEGNGIG---VYNVNQRLIGlfgeesRLFIENNVNGGCRFSFNIP 574
Cdd:COG4191  317 tkpV--GKGTGLGlsiSYGIVEKHGG------RIEVESEPGGGTTFTITLP 359
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
420-574 2.61e-09

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 59.57  E-value: 2.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 420 LNIKLIASHTISIQQEIMHLSSYLEIIQIRFKDQ-----ITMEVQLDSDLLIAMIPPVTLQP----LVENCIKHGlkdrN 490
Cdd:COG5002  223 LDLSRLESGELKLEKEPVDLAELLEEVVEELRPLaeekgIELELDLPEDPLLVLGDPDRLEQvltnLLDNAIKYT----P 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 491 HGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEQL-------GNEPVNSSEGNGIGVYNVnQRLIGLFGeeSRLFIENNV 563
Cdd:COG5002  299 EGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIferfyrvDKSRSRETGGTGLGLAIV-KHIVEAHG--GRIWVESEP 375

                        170
                 ....*....|.
gi 950270992 564 NGGCRFSFNIP 574
Cdd:COG5002  376 GKGTTFTITLP 386
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 477-574 5.51e-09

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 58.32  E-value: 5.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 477 LVENCIKHGLKDRNHGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEQL--GNEPVNSSEGNGIGVYNVNQRLIGLFGEe 554
Cdd:COG3290  289 LLDNAIEAVEKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIfeRGFSTKLGEGRGLGLALVKQIVEKYGGT- 367

                         90       100
                 ....*....|....*....|
gi 950270992 555 srLFIENNVNGGCRFSFNIP 574
Cdd:COG3290  368 --IEVESEEGEGTVFTVRLP 385
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 474-578 3.27e-08

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 56.33  E-value: 3.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 474 LQPLVENCIKHGlkDRNHGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEQLGN-----EPVNSSEGNGIGVYNVnQRLI 548
Cdd:COG4251  399 FQNLISNAIKYS--RPGEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEifqrlHSRDEYEGTGIGLAIV-KKIV 475

                         90       100       110
                 ....*....|....*....|....*....|
gi 950270992 549 GLFGeeSRLFIENNVNGGCRFSFNIPGTST 578
Cdd:COG4251  476 ERHG--GRIWVESEPGEGATFYFTLPKAPA 503
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 455-568 6.04e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 51.25  E-value: 6.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 455 TMEVQLDSDLLIAMippvtLQPLVENCIKHGlkdrNHGGRIRIeVLNHKDTLQISIEDNGSGIPPELLEQLGNE----PV 530
Cdd:cd16940    4 DIQVQGDALLLFLL-----LRNLVDNAVRYS----PQGSRVEI-KLSADDGAVIRVEDNGPGIDEEELEALFERfyrsDG 73

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 950270992 531 NSSEGNGIGVYNVnQRLIGLFGeeSRLFIENNVNGGCR 568
Cdd:cd16940   74 QNYGGSGLGLSIV-KRIVELHG--GQIFLGNAQGGGLE 108
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
477-545 6.67e-08

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 51.45  E-value: 6.67e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 950270992 477 LVENCIKHGLKDrNHGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEqlgnEPVNSSEGNGIGVYNVNQ 545
Cdd:COG2172   42 AVTNAVRHAYGG-DPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLP----DPYSTLAEGGRGLFLIRR 105
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 453-574 2.42e-07

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 53.43  E-value: 2.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 453 QITMEVQLDSDLLIAMIPPVTLQPLVENCIKHGLKDRNHGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEQLGnEPVNS 532
Cdd:COG5000  297 DIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIF-EPFFT 375

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 950270992 533 --SEGNGIGVYNVnQRLIglfgEES--RLFIENNVNGGCRFSFNIP 574
Cdd:COG5000  376 tkPKGTGLGLAIV-KKIV----EEHggTIELESRPGGGTTFTIRLP 416
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 477-574 7.05e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 47.67  E-value: 7.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 477 LVENCIKHGLKDRNHGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEQLGNEPVNSSE--GNGIGVYNVNQRLIGLFGEe 554
Cdd:cd16915    8 LIDNALDALAATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGqgERGIGLALVRQSVERLGGS- 86

                         90       100
                 ....*....|....*....|
gi 950270992 555 srLFIENNVNGGCRFSFNIP 574
Cdd:cd16915   87 --ITVESEPGGGTTFSIRIP 104
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 474-574 7.20e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 47.78  E-value: 7.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 474 LQPLVENCIKHGLKDRNHGGRIRIEVL-----NHKDTLQISIEDNGSGIPPELLEQLGNEPVNS-SEGNGIGVyNVNQRL 547
Cdd:cd16920    1 IQQVLINLVRNGIEAMSEGGCERRELTirtspADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTkSEGLGMGL-SICRSI 79

                         90       100
                 ....*....|....*....|....*..
gi 950270992 548 IGLFGeeSRLFIENNVNGGCRFSFNIP 574
Cdd:cd16920   80 IEAHG--GRLSVESPAGGGATFQFTLP 104
KinD COG5808
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ...
 474-574 1.44e-06

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444510 [Multi-domain]  Cd Length: 454  Bit Score: 50.90  E-value: 1.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 474 LQPLVENCIKHGLKDRNHGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEQLGNEPVNSSE-GNGIGVYnVNQRLIGLFG 552
Cdd:COG5808  352 IKQVLLNLIKNAIEAMKEGGKLTISIENDDEKAVIEVIDNGEGIPEDIIDEIFEPFVTTKEgGTGLGLS-VCKRIVEMHG 430

                         90       100
                 ....*....|....*....|..
gi 950270992 553 eeSRLFIENNVNGGCRFSFNIP 574
Cdd:COG5808  431 --GEIDIESEEGKGTTFTIRLP 450
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 153-521 2.68e-06

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 50.29  E-value: 2.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 153 AIFIGMFAPIVQMGIILIVSVPSKIAIELVDLIGIPMVLTNSISIAIFTTMLRVVFREEERAVAYETQRALHIAEAALPH 232
Cdd:COG3920   62 ALAAALAVALAAAVGAAAALLALLVLLLLLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLL 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 233 LKQGLTYQSADAIARLLLREHKTAAVAITDTENILAHAGLGDMILIPGEPIRSELSRQAIGTGKLQIALNHEDIQPNHRL 312
Cdd:COG3920  142 AILALAELAVALAELAAALLLLAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLA 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 313 LRAAIIVPIKQAGQVAGLIKLYFKKPQEIRSVEIVLAEGLGKLLSYQLSVAMHESMEALMKESELRILQSQINPHFLF-- 390
Cdd:COG3920  222 LLLVLLAALLRLRAAVLEELERRRRARGLGRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEKELLLre 301

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 391 ------NTLNSIISLIRIEpdmARHITmqlSTYMRLNIKLIAS--HTISIQQEIMHLSSYLEIIQIR--FKDQITMEVQL 460
Cdd:COG3920  302 lhhrvkNNLQVVSSLLRLQ---ARRAD---DPEAREALEESQNriQALALVHELLYQSEDWEGVDLRdyLRELLEPLRDS 375

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 950270992 461 DSDLLIAM---IPPVTLQP------------LVENCIKHGLKDRNhGGRIRIEVLNHKDTLQISIEDNGSGIPPEL 521
Cdd:COG3920  376 YGGRGIRIeldGPDVELPAdaavplglilneLVTNALKHAFLSGE-GGRIRVSWRREDGRLRLTVSDNGVGLPEDV 450
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
451-574 3.85e-06

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 49.97  E-value: 3.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 451 KDQITMEVQLDSDLLIAMIPPVTLQPLVENCIKHGLKDRNHGGRIRIEV-LNHKDTLQISIEDNGSGIPPELLEQLgNEP 529
Cdd:PRK11360 478 QARVDFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTwQYSDGQVAVSIEDNGCGIDPELLKKI-FDP 556

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 950270992 530 VNS--SEGNGIGVyNVNQRLIGLFGeeSRLFIENNVNGGCRFSFNIP 574
Cdd:PRK11360 557 FFTtkAKGTGLGL-ALSQRIINAHG--GDIEVESEPGVGTTFTLYLP 600
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 477-574 4.06e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 45.66  E-value: 4.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 477 LVENCIKHglkdRNHGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEQLGN-------EPVNSSEGNGIGVYNVNQRLIg 549
Cdd:cd16952    8 LVSNAVKY----TPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTErfyrvdiERCRNTGGTGLGLAIVKHVMS- 82

                         90       100
                 ....*....|....*....|....*
gi 950270992 550 lfGEESRLFIENNVNGGCRFSFNIP 574
Cdd:cd16952   83 --RHDARLLIASELGKGSRFTCLFP 105
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
397-529 7.49e-06

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 48.30  E-value: 7.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 397 ISLIRIEPDMARHITMQLSTYMRLniKLIASHTISIQQEIMHLssyLEIIQIRFKDQITMEVQLDSDLLIAMIPPVTLQP 476
Cdd:COG3852  173 TQLIIEEADRLNNLVDRLLSFSRP--RPPEREPVNLHEVLERV---LELLRAEAPKNIRIVRDYDPSLPEVLGDPDQLIQ 247

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 950270992 477 LVENCIKHGLKDRNHGGRIRIEV----------LNHKDTLQISIEDNGSGIPPELLEQLGnEP 529
Cdd:COG3852  248 VLLNLVRNAAEAMPEGGTITIRTrverqvtlggLRPRLYVRIEVIDNGPGIPEEILDRIF-EP 309
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 493-574 8.32e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 44.72  E-value: 8.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 493 GRIRIEVLNHKDTLQISIEDNGSGIPPELLEQL-----GNEPVnsSEGNGIGVyNVNQRLIGLFGEESRlfIENNVNGGC 567
Cdd:cd16943   23 GRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIfdpffTTKPV--GEGTGLGL-SLSYRIIQKHGGTIR--VASVPGGGT 97


                 ....*..
gi 950270992 568 RFSFNIP 574
Cdd:cd16943   98 RFTIILP 104
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 474-574 1.27e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 44.24  E-value: 1.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 474 LQPLVENCIKHGLKDRNhgGRIRIEVLNHKDTLQISIEDNGSGIPPELLEQLGN-----EPVNSSEGNGIGVyNVNQRLI 548
Cdd:cd16921    5 LTNLLGNAIKFRRPRRP--PRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGifqrlHSREEYEGTGVGL-AIVRKII 81

                         90       100
                 ....*....|....*....|....*.
gi 950270992 549 GLFGeeSRLFIENNVNGGCRFSFNIP 574
Cdd:cd16921   82 ERHG--GRIWLESEPGEGTTFYFTLP 105
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 477-574 1.32e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 45.10  E-value: 1.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 477 LVENCIKHGLKDRNHGG-RIRIEVLNhkDTLQISIEDNGSGIPpelleqlgnEPVNSSEGNGIGVYNVNQRLIG-LFGEE 554
Cdd:cd16951   47 LLQNALKHAFSDREGGTiTIRSVVDG--DYLRITVIDDGVGLP---------QDEDWPNKGSLGLQIVRSLVEGeLKAFL 115

                         90       100
                 ....*....|....*....|
gi 950270992 555 SRLFIENnvngGCRFSFNIP 574
Cdd:cd16951  116 EVQSAEN----GTRVNIDIP 131
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
449-574 3.55e-05

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 45.76  E-value: 3.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 449 RFKDQITMEVQLDSDLLIAMIPPVT-------LQPLVENCIKHGlkdrnHGGRIRIEVLNHKDTLQISIEDNGSGIPPEl 521
Cdd:COG4585  135 RLLRAAGIRVELDVDGDPDRLPPEVelalyriVQEALTNALKHA-----GATRVTVTLEVDDGELTLTVRDDGVGFDPE- 208

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 950270992 522 leqlgnepvnSSEGNGIGVYNVNQRLIGLFGeesRLFIENNVNGGCRFSFNIP 574
Cdd:COG4585  209 ----------AAPGGGLGLRGMRERAEALGG---TLTIGSAPGGGTRVRATLP 248
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
364-574 1.41e-04

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 44.62  E-value: 1.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 364 MHES-MEALMKESELRILQSQINPhflFNTL-NSIISLIRIE--PDMARHITMQLSTYMRLnikliashtisIQQEIMHL 439
Cdd:PRK11006 229 MQDQpLEGALREKALHTMREQTQR---MEGLvKQLLTLSKIEaaPTIDLNEKVDVPMMLRV-----------LEREAQTL 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 440 SSYLEIIQIRFKDQITM---EVQLDSdlliAMippvtlQPLVENCIKHGLKdrnhGGRIRIEVLNHKDTLQISIEDNGSG 516
Cdd:PRK11006 295 SQGKHTITFEVDNSLKVfgnEDQLRS----AI------SNLVYNAVNHTPE----GTHITVRWQRVPQGAEFSVEDNGPG 360

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 950270992 517 IPPELLEQLGN-----EPVNSSE--GNGIGVYNVNQrliGLFGEESRLFIENNVNGGCRFSFNIP 574
Cdd:PRK11006 361 IAPEHIPRLTErfyrvDKARSRQtgGSGLGLAIVKH---ALSHHDSRLEIESEVGKGTRFSFVLP 422
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 477-574 2.35e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 40.73  E-value: 2.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 477 LVENCIKHGLKdrnhGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEQL------GNEPVNSSEGNGIGVYNVNQrLIGL 550
Cdd:cd16948   13 IVSNALKYSKQ----GGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVfdkgftGENGRNFQESTGMGLYLVKK-LCDK 87

                         90       100
                 ....*....|....*....|....
gi 950270992 551 FGEEsrLFIENNVNGGCRFSFNIP 574
Cdd:cd16948   88 LGHK--IDVESEVGEGTTFTITFP 109
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 429-539 2.37e-04

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 43.95  E-value: 2.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 429 TISIQQEIMHLSSYLEIIQIrfKDQITMEVQLDSDLLIAMIPPVTLQPLVENCIKHGLKDRNHGGRIRIEVLNHKDTLQI 508
Cdd:COG5805  353 KENINELIQDVVTLLETEAI--LHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVII 430

                         90       100       110
                 ....*....|....*....|....*....|.
gi 950270992 509 SIEDNGSGIPPELLEQLGnEPVNSSEGNGIG 539
Cdd:COG5805  431 RVIDEGIGIPEERLKKLG-EPFFTTKEKGTG 460
PRK09303 PRK09303
histidine kinase;
477-574 7.43e-04

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 42.25  E-value: 7.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 477 LVENCIKHglkdRNHGGRIRIEVLnHKDT--LQISIEDNGSGIPPELLEQLGNEPV-----NSSEGNGIGVyNVNQRLIG 549
Cdd:PRK09303 280 LLDNAIKY----TPEGGTITLSML-HRTTqkVQVSICDTGPGIPEEEQERIFEDRVrlprdEGTEGYGIGL-SVCRRIVR 353

                         90       100
                 ....*....|....*....|....*
gi 950270992 550 LFGeeSRLFIENNVNGGCRFSFNIP 574
Cdd:PRK09303 354 VHY--GQIWVDSEPGQGSCFHFTLP 376
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 480-539 1.04e-03

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 41.88  E-value: 1.04e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 950270992 480 NCIKHGLKDRNHGGRIRIEVLNHKDT-LQISIEDNGSGIPPELLEQLGnEP--VNSSEGNGIG 539
Cdd:COG5809  386 NLLKNAIEAMPEGGNITIETKAEDDDkVVISVTDEGCGIPEERLKKLG-EPfyTTKEKGTGLG 447
GAF_2 pfam13185
GAF domain; The GAF domain is named after some of the proteins it is found in, including ...
 240-365 1.50e-03

GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 433019 [Multi-domain]  Cd Length: 137  Bit Score: 38.99  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992  240 QSADAIARLLLRE------HKTAAVAITDTENILAHAGLGDMILI--PGEPIRSELSRQAIGTGKLQIALNHEDIQPNHR 311
Cdd:pfam13185   2 ADLEELLDAVLEAavelgaSAVGFILLVDDDGRLAAWGGAADELSaaLDDPPGEGLVGEALRTGRPVIVNDLAADPAKKG 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992  312 L------LRAAIIVPIKQAGQVAGLIKLYFKKPQEIRSVEIVLAEglgkLLSYQLSVAMH 365
Cdd:pfam13185  82 LpaghagLRSFLSVPLVSGGRVVGVLALGSNRPGAFDEEDLELLE----LLAEQAAIAIE 137
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 474-526 1.95e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 38.21  E-value: 1.95e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 950270992 474 LQPLVENCIKHGLKDRNHGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEQLG 526
Cdd:cd16946    5 LQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLF 57
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 474-574 2.54e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 37.79  E-value: 2.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 474 LQPLVENCIKHGLKdrnhggRIRIEVLNHKDTLQISIEDNGSGIPPELLEQ-------LGNEPVNSSEGNGIGVYNVnQR 546
Cdd:cd16939    5 LDNLLRNALRYAHR------TVRIALLVSGGRLTLIVEDDGPGIPAAARERvfepfvrLDPSRDRATGGFGLGLAIV-HR 77

                         90       100
                 ....*....|....*....|....*...
gi 950270992 547 LIGLFGeeSRLFIENNVNGGCRFSFNIP 574
Cdd:cd16939   78 VALWHG--GHVECDDSELGGACFRLTWP 103
PRK10490 PRK10490
sensor protein KdpD; Provisional
 474-574 2.95e-03

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 40.79  E-value: 2.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 474 LQPLVENCIKHGLKDRNHGGRIRIEvlnhKDTLQISIEDNGSGIPPElLEQL-------GNEPvNSSEGNGIGVyNVNQR 546
Cdd:PRK10490 783 LINLLENAVKYAGAQAEIGIDAHVE----GERLQLDVWDNGPGIPPG-QEQLifdkfarGNKE-SAIPGVGLGL-AICRA 855

                         90       100
                 ....*....|....*....|....*...
gi 950270992 547 LIGLFGeeSRLFIENNVNGGCRFSFNIP 574
Cdd:PRK10490 856 IVEVHG--GTIWAENRPEGGACFRVTLP 881
envZ PRK09467
osmolarity sensor protein; Provisional
 457-539 3.47e-03

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 40.28  E-value: 3.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 457 EVQLDSDLliAMIP-PVTLQP---------LVENCIKHGlkdrnhGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEQL- 525
Cdd:PRK09467 311 EREIETAL--QPGPiEVPMNPiaikralanLVVNAARYG------NGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLf 382

                         90
                 ....*....|....*....
gi 950270992 526 -----GNEpVNSSEGNGIG 539
Cdd:PRK09467 383 qpftrGDS-ARGSSGTGLG 400
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 502-539 4.26e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 37.38  E-value: 4.26e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 950270992 502 HKDTLQISIEDNGSGIPPELLEQLgNEPVNSSEGNGIG 539
Cdd:cd16918   40 HRLALRVSVIDNGPGIPPDLQDTI-FYPMVSGRENGTG 76
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
471-524 4.33e-03

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 39.92  E-value: 4.33e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 950270992 471 PVTLQPLVENCIKHGLKDRNHggRIRIEVLNHKDTLQISIEDNGSGIPPELLEQ 524
Cdd:PRK09470 351 PNALASALENIVRNALRYSHT--KIEVAFSVDKDGLTITVDDDGPGVPEEEREQ 402
PRK10604 PRK10604
sensor protein RstB; Provisional
 478-574 4.61e-03

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 39.59  E-value: 4.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950270992 478 VENCIKHGLkdRNHGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEQLgNEPV--------NSSEGNGIGVYNVNQRLIG 549
Cdd:PRK10604 324 LDNLLNNAL--RYAHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERV-FEPFvrldpsrdRATGGCGLGLAIVHSIALA 400

                         90       100
                 ....*....|....*....|....*
gi 950270992 550 LFGEesrLFIENNVNGGCRFSFNIP 574
Cdd:PRK10604 401 MGGS---VNCDESELGGARFSFSWP 422
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 477-541 5.86e-03

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 36.48  E-value: 5.86e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 950270992 477 LVENCIKHGLKDRnHGGRIRIEVLNHKDTLQISIEDNGSGIPPELLEqlgnEPVNSSEGNGIGVY 541
Cdd:cd16936    8 AVTNAVRHAYRHD-GPGPVRLELDLDPDRLRVEVTDSGPGFDPLRPA----DPDAGLREGGRGLA 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH