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Conserved domains on  [gi|983069628|ref|WP_060419184|]
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MULTISPECIES: pyruvate kinase PykF [Serratia]

Protein Classification

pyruvate kinase PykF( domain architecture ID 11483648)

pyruvate kinase PykF catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09206 PRK09206
pyruvate kinase PykF;
1-470 0e+00

pyruvate kinase PykF;


:

Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 1046.18  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628   1 MKKTKIVCTIGPKTESEEMLTNLLNAGMNVMRLNFSHGDYEEHGNRIKNMRAVMAKTGINAGILLDTKGPEIRTMKLEGG 80
Cdd:PRK09206   1 MKKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  81 KDASLVAGQTFTFTTDQSVIGNSDRVAVTYAGFAADLKIGNTVLVDDGLIGMEVTNVTENEVICKVLNNGDLGENKGVNL 160
Cdd:PRK09206  81 NDVSLKAGQTFTFTTDKSVVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKGVNL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 161 PGVSIQLPALAEKDKRDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGEQIQIISKIENQEGLNNFDEILEASDGI 240
Cdd:PRK09206 161 PGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGENIQIISKIENQEGLNNFDEILEASDGI 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 241 MVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKY 320
Cdd:PRK09206 241 MVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKY 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 321 PLEAVNIMATICERTDRVMPSRIDTLNDRRKLRITEAVCRGAVETAEKLDAPLIVVATSGGKSAKSVRKYFPNAVILALT 400
Cdd:PRK09206 321 PLEAVSIMATICERTDRVMNSRLESNNDNRKLRITEAVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYFPDATILALT 400

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 401 TNETTAHQLVLSKGVIPQMVKEIASTDDFYRIGKEAALASGLAQKGDVVVMVSGALVPSGTTNTASVHVL 470
Cdd:PRK09206 401 TNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVVMVSGALVPSGTTNTASVHVL 470
 
Name Accession Description Interval E-value
PRK09206 PRK09206
pyruvate kinase PykF;
1-470 0e+00

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 1046.18  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628   1 MKKTKIVCTIGPKTESEEMLTNLLNAGMNVMRLNFSHGDYEEHGNRIKNMRAVMAKTGINAGILLDTKGPEIRTMKLEGG 80
Cdd:PRK09206   1 MKKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  81 KDASLVAGQTFTFTTDQSVIGNSDRVAVTYAGFAADLKIGNTVLVDDGLIGMEVTNVTENEVICKVLNNGDLGENKGVNL 160
Cdd:PRK09206  81 NDVSLKAGQTFTFTTDKSVVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKGVNL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 161 PGVSIQLPALAEKDKRDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGEQIQIISKIENQEGLNNFDEILEASDGI 240
Cdd:PRK09206 161 PGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGENIQIISKIENQEGLNNFDEILEASDGI 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 241 MVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKY 320
Cdd:PRK09206 241 MVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKY 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 321 PLEAVNIMATICERTDRVMPSRIDTLNDRRKLRITEAVCRGAVETAEKLDAPLIVVATSGGKSAKSVRKYFPNAVILALT 400
Cdd:PRK09206 321 PLEAVSIMATICERTDRVMNSRLESNNDNRKLRITEAVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYFPDATILALT 400

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 401 TNETTAHQLVLSKGVIPQMVKEIASTDDFYRIGKEAALASGLAQKGDVVVMVSGALVPSGTTNTASVHVL 470
Cdd:PRK09206 401 TNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVVMVSGALVPSGTTNTASVHVL 470
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 1-470 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 724.13  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628   1 MKKTKIVCTIGPKTESEEMLTNLLNAGMNVMRLNFSHGDYEEHGNRIKNMRAVMAKTGINAGILLDTKGPEIRTMKLEGG 80
Cdd:COG0469    2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  81 KdASLVAGQTFTFTTDqSVIGNSDRVAVTYAGFAADLKIGNTVLVDDGLIGMEVTNVTENEVICKVLNNGDLGENKGVNL 160
Cdd:COG0469   82 P-VELKKGDTFTLTTD-DVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 161 PGVSIQLPALAEKDKRDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGeQIQIISKIENQEGLNNFDEILEASDGI 240
Cdd:COG0469  160 PGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGG-RAPIIAKIEKPEAVENLDEIIEASDGI 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 241 MVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKY 320
Cdd:COG0469  239 MVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKY 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 321 PLEAVNIMATICERTDRVMPSR--IDTLNDRRKLRITEAVCRGAVETAEKLDAPLIVVATSGGKSAKSVRKYFPNAVILA 398
Cdd:COG0469  319 PVEAVETMARIAEEAEKSLDYRriLDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILA 398

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 983069628 399 LTTNETTAHQLVLSKGVIPQMVKEIASTDDFYRIGKEAALASGLAQKGDVVVMVSGALV-PSGTTNTASVHVL 470
Cdd:COG0469  399 LTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVgVPGTTNTLKVHRV 471
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 1-470 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 709.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628   1 MKKTKIVCTIGPKTESEEMLTNLLNAGMNVMRLNFSHGDYEEHGNRIKNMRAVMAKTGINAGILLDTKGPEIRTMKLEGG 80
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  81 KDASLVAGQTFTFTTDQS-VIGNSDRVAVTYAGFAADLKIGNTVLVDDGLIGMEVTNVTEN-EVICKVLNNGDLGENKGV 158
Cdd:cd00288   81 KDISLKAGDKFLVTTDPAaKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNGGVLGSRKGV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 159 NLPGVSIQLPALAEKDKRDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGgEQIQIISKIENQEGLNNFDEILEASD 238
Cdd:cd00288  161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKG-KDIKIIAKIENQEGVNNFDEILEASD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 239 GIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKG 318
Cdd:cd00288  240 GIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 319 KYPLEAVNIMATICERTDRVMPSRiDTLNDRRKL-----RITEAVCRGAVETAEKLDAPLIVVATSGGKSAKSVRKYFPN 393
Cdd:cd00288  320 KYPVEAVKAMARICLEAEKALSHR-VLFNEMRRLtprptSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPN 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 394 AVILALTTNETTAHQLVLSKGVIPQMVKEIA---STDDFYRI--GKEAALASGLAQKGDVVVMVSGALVPSGTTNTASVH 468
Cdd:cd00288  399 APIIAVTRNEQTARQLHLYRGVYPVLFEEPKpgwQEDTDARLkaAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTMRIL 478


                 ..
gi 983069628 469 VL 470
Cdd:cd00288  479 TV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 2-467 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 653.96  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628    2 KKTKIVCTIGPKTESEEMLTNLLNAGMNVMRLNFSHGDYEEHGNRIKNMRAVMAKTGINAGILLDTKGPEIRTMKLEGGk 81
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGG- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628   82 DASLVAGQTFTFTTD-QSVIGNSDRVAVTYAGFAADLKIGNTVLVDDGLIGMEVTNVTENEVICKVLNNGDLGENKGVNL 160
Cdd:TIGR01064  80 EVKLKKGDKVIITTDdIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  161 PGVSIQLPALAEKDKRDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGEQIQIISKIENQEGLNNFDEILEASDGI 240
Cdd:TIGR01064 160 PGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASDGI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  241 MVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKY 320
Cdd:TIGR01064 240 MVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKY 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  321 PLEAVNIMATICERTDRVMpSRIDTLNDR-----RKLRITEAVCRGAVETAEKLDAPLIVVATSGGKSAKSVRKYFPNAV 395
Cdd:TIGR01064 320 PVEAVQMMAKIAKEAEKAL-AYLTNFNDRknsdpKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAP 398

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 983069628  396 ILALTTNETTAHQLVLSKGVIPQMVKEIAS-TDDFYRIGKEAALASGLAQKGDVVVMVSG-ALVPSGTTNTASV 467
Cdd:TIGR01064 399 IIAVTPNERVARQLALYWGVFPFLVDEEPSdTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEGGTNTIRV 472
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 1-342 7.97e-179

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 504.21  E-value: 7.97e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628    1 MKKTKIVCTIGPKTESEEMLTNLLNAGMNVMRLNFSHGDYEEHGNRIKNMRAVMAKTGINAGILLDTKGPEIRTMKLEGG 80
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628   81 KDA-SLVAGQTFTFTTDQSVIGNSDR--VAVTYAGFAADLKIGNTVLVDDGLIGMEVTNVTENE-VICKVLNNGDLGENK 156
Cdd:pfam00224  81 KKDiELKAGDEMIVSTDAKYKGACDDemIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSRK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  157 GVNLPGVSIQLPALAEKDKRDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGgEQIQIISKIENQEGLNNFDEILEA 236
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAG-KNIQIIAKIENQEGVNNFDEILEA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  237 SDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESA 316
Cdd:pfam00224 240 TDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 319

                         330       340
                  ....*....|....*....|....*.
gi 983069628  317 KGKYPLEAVNIMATICERTDRVMPSR 342
Cdd:pfam00224 320 KGNYPVEAVRMMHEICLEAEKALPHR 345
 
Name Accession Description Interval E-value
PRK09206 PRK09206
pyruvate kinase PykF;
1-470 0e+00

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 1046.18  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628   1 MKKTKIVCTIGPKTESEEMLTNLLNAGMNVMRLNFSHGDYEEHGNRIKNMRAVMAKTGINAGILLDTKGPEIRTMKLEGG 80
Cdd:PRK09206   1 MKKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  81 KDASLVAGQTFTFTTDQSVIGNSDRVAVTYAGFAADLKIGNTVLVDDGLIGMEVTNVTENEVICKVLNNGDLGENKGVNL 160
Cdd:PRK09206  81 NDVSLKAGQTFTFTTDKSVVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKGVNL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 161 PGVSIQLPALAEKDKRDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGEQIQIISKIENQEGLNNFDEILEASDGI 240
Cdd:PRK09206 161 PGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGENIQIISKIENQEGLNNFDEILEASDGI 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 241 MVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKY 320
Cdd:PRK09206 241 MVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKY 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 321 PLEAVNIMATICERTDRVMPSRIDTLNDRRKLRITEAVCRGAVETAEKLDAPLIVVATSGGKSAKSVRKYFPNAVILALT 400
Cdd:PRK09206 321 PLEAVSIMATICERTDRVMNSRLESNNDNRKLRITEAVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYFPDATILALT 400

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 401 TNETTAHQLVLSKGVIPQMVKEIASTDDFYRIGKEAALASGLAQKGDVVVMVSGALVPSGTTNTASVHVL 470
Cdd:PRK09206 401 TNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVVMVSGALVPSGTTNTASVHVL 470
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 1-470 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 724.13  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628   1 MKKTKIVCTIGPKTESEEMLTNLLNAGMNVMRLNFSHGDYEEHGNRIKNMRAVMAKTGINAGILLDTKGPEIRTMKLEGG 80
Cdd:COG0469    2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  81 KdASLVAGQTFTFTTDqSVIGNSDRVAVTYAGFAADLKIGNTVLVDDGLIGMEVTNVTENEVICKVLNNGDLGENKGVNL 160
Cdd:COG0469   82 P-VELKKGDTFTLTTD-DVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 161 PGVSIQLPALAEKDKRDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGeQIQIISKIENQEGLNNFDEILEASDGI 240
Cdd:COG0469  160 PGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGG-RAPIIAKIEKPEAVENLDEIIEASDGI 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 241 MVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKY 320
Cdd:COG0469  239 MVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKY 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 321 PLEAVNIMATICERTDRVMPSR--IDTLNDRRKLRITEAVCRGAVETAEKLDAPLIVVATSGGKSAKSVRKYFPNAVILA 398
Cdd:COG0469  319 PVEAVETMARIAEEAEKSLDYRriLDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILA 398

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 983069628 399 LTTNETTAHQLVLSKGVIPQMVKEIASTDDFYRIGKEAALASGLAQKGDVVVMVSGALV-PSGTTNTASVHVL 470
Cdd:COG0469  399 LTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVgVPGTTNTLKVHRV 471
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 1-470 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 709.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628   1 MKKTKIVCTIGPKTESEEMLTNLLNAGMNVMRLNFSHGDYEEHGNRIKNMRAVMAKTGINAGILLDTKGPEIRTMKLEGG 80
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  81 KDASLVAGQTFTFTTDQS-VIGNSDRVAVTYAGFAADLKIGNTVLVDDGLIGMEVTNVTEN-EVICKVLNNGDLGENKGV 158
Cdd:cd00288   81 KDISLKAGDKFLVTTDPAaKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNGGVLGSRKGV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 159 NLPGVSIQLPALAEKDKRDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGgEQIQIISKIENQEGLNNFDEILEASD 238
Cdd:cd00288  161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKG-KDIKIIAKIENQEGVNNFDEILEASD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 239 GIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKG 318
Cdd:cd00288  240 GIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 319 KYPLEAVNIMATICERTDRVMPSRiDTLNDRRKL-----RITEAVCRGAVETAEKLDAPLIVVATSGGKSAKSVRKYFPN 393
Cdd:cd00288  320 KYPVEAVKAMARICLEAEKALSHR-VLFNEMRRLtprptSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPN 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 394 AVILALTTNETTAHQLVLSKGVIPQMVKEIA---STDDFYRI--GKEAALASGLAQKGDVVVMVSGALVPSGTTNTASVH 468
Cdd:cd00288  399 APIIAVTRNEQTARQLHLYRGVYPVLFEEPKpgwQEDTDARLkaAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTMRIL 478


                 ..
gi 983069628 469 VL 470
Cdd:cd00288  479 TV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 2-467 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 653.96  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628    2 KKTKIVCTIGPKTESEEMLTNLLNAGMNVMRLNFSHGDYEEHGNRIKNMRAVMAKTGINAGILLDTKGPEIRTMKLEGGk 81
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGG- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628   82 DASLVAGQTFTFTTD-QSVIGNSDRVAVTYAGFAADLKIGNTVLVDDGLIGMEVTNVTENEVICKVLNNGDLGENKGVNL 160
Cdd:TIGR01064  80 EVKLKKGDKVIITTDdIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  161 PGVSIQLPALAEKDKRDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGEQIQIISKIENQEGLNNFDEILEASDGI 240
Cdd:TIGR01064 160 PGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASDGI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  241 MVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKY 320
Cdd:TIGR01064 240 MVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKY 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  321 PLEAVNIMATICERTDRVMpSRIDTLNDR-----RKLRITEAVCRGAVETAEKLDAPLIVVATSGGKSAKSVRKYFPNAV 395
Cdd:TIGR01064 320 PVEAVQMMAKIAKEAEKAL-AYLTNFNDRknsdpKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAP 398

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 983069628  396 ILALTTNETTAHQLVLSKGVIPQMVKEIAS-TDDFYRIGKEAALASGLAQKGDVVVMVSG-ALVPSGTTNTASV 467
Cdd:TIGR01064 399 IIAVTPNERVARQLALYWGVFPFLVDEEPSdTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEGGTNTIRV 472
PRK05826 PRK05826
pyruvate kinase; Provisional
 1-462 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 613.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628   1 MKKTKIVCTIGPKTESEEMLTNLLNAGMNVMRLNFSHGDYEEHGNRIKNMRAVMAKTGINAGILLDTKGPEIRTMKLEGG 80
Cdd:PRK05826   3 LRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKEG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  81 KdASLVAGQTFTFTTDQSVIGNSDRVAVTYAGFAADLKIGNTVLVDDGLIGMEVTNVTENEVICKVLNNGDLGENKGVNL 160
Cdd:PRK05826  83 K-ITLKTGDKFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 161 PGVSIQLPALAEKDKRDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGEQIQIISKIENQEGLNNFDEILEASDGI 240
Cdd:PRK05826 162 PGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPHAKIIAKIERAEAVDNIDEIIEASDGI 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 241 MVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKY 320
Cdd:PRK05826 242 MVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKY 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 321 PLEAVNIMATICERTDRvMPSRID--TLNDRRKLRITEAVCRGAVETAEKL-DAPLIVVATSGGKSAKSVRKYFPNAVIL 397
Cdd:PRK05826 322 PVEAVEAMARICKGAEK-EFSINLskHRLDRQFDRIDEAIAMSAMYAANHLkGVKAIVALTESGRTARLISRFRPGAPIF 400

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 983069628 398 ALTTNETTAHQLVLSKGVIPQMVKEIASTDDFYRIGKEAALASGLAQKGDVVVMVSGalVPSGTT 462
Cdd:PRK05826 401 AVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSG--DPMGTA 463
PRK06354 PRK06354
pyruvate kinase; Provisional
 1-469 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 599.22  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628   1 MKKTKIVCTIGPKTESEEMLTNLLNAGMNVMRLNFSHGDYEEHGNRIKNMRAVMAKTGINAGILLDTKGPEIRTMKLEGG 80
Cdd:PRK06354   7 MRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  81 KdASLVAGQTFTFTTDQsVIGNSDRVAVTYAGFAADLKIGNTVLVDDGLIGMEVTNV--TENEVICKVLNNGDLGENKGV 158
Cdd:PRK06354  87 P-IELKTGDEFILTSRE-VLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVdkADGELHCKVLVGGVLSNKKGV 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 159 NLPGVSIQLPALAEKDKRDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGEQIQIISKIENQEGLNNFDEILEASD 238
Cdd:PRK06354 165 NFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKHIPIIAKIEKQEAIDNIDAILELCD 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 239 GIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKG 318
Cdd:PRK06354 245 GLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAG 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 319 KYPLEAVNIMATICERTDRVMPSR-IDTLNDRRKLRITEAVCRGAVETAEKLDAPLIVVATSGGKSAKSVRKYFPNAVIL 397
Cdd:PRK06354 325 DYPVEAVQTMATIAVRIEKDLPYRdILSKRPEFTTTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPKTPIL 404

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 983069628 398 ALTTNETTAHQLVLSKGVIPQMVKEIASTDDFYRIGKEAALASGLAQKGDVVVMVSGALV-PSGTTNTASVHV 469
Cdd:PRK06354 405 AVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVgESGSTDLMKVHV 477
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 1-342 7.97e-179

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 504.21  E-value: 7.97e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628    1 MKKTKIVCTIGPKTESEEMLTNLLNAGMNVMRLNFSHGDYEEHGNRIKNMRAVMAKTGINAGILLDTKGPEIRTMKLEGG 80
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628   81 KDA-SLVAGQTFTFTTDQSVIGNSDR--VAVTYAGFAADLKIGNTVLVDDGLIGMEVTNVTENE-VICKVLNNGDLGENK 156
Cdd:pfam00224  81 KKDiELKAGDEMIVSTDAKYKGACDDemIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSRK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  157 GVNLPGVSIQLPALAEKDKRDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGgEQIQIISKIENQEGLNNFDEILEA 236
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAG-KNIQIIAKIENQEGVNNFDEILEA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  237 SDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESA 316
Cdd:pfam00224 240 TDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 319

                         330       340
                  ....*....|....*....|....*.
gi 983069628  317 KGKYPLEAVNIMATICERTDRVMPSR 342
Cdd:pfam00224 320 KGNYPVEAVRMMHEICLEAEKALPHR 345
PLN02461 PLN02461
Probable pyruvate kinase
 2-450 3.42e-176

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 503.74  E-value: 3.42e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628   2 KKTKIVCTIGPKTESEEMLTNLLNAGMNVMRLNFSHGDYEEHGNRIKNMRAVMAKTGINAGILLDTKGPEIRTMKLEGGK 81
Cdd:PLN02461  21 PKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFLKDGK 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  82 DASLVAGQTFTFTTDQSVIGNSDRVAVTYAGFAADLKIGNTVLVDDGLIGMEV--TNVTENEVICKVLNNGDLGENKGVN 159
Cdd:PLN02461 101 PVQLKQGQEITITTDYSIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVlsCDVEAGTVRCRCENSAMLGERKNVN 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 160 LPGVSIQLPALAEKDKRDLI-FGCEQGVDFVAASFIRKRSDVLEIREHLKAHGgEQIQIISKIENQEGLNNFDEILEASD 238
Cdd:PLN02461 181 LPGVVVDLPTLTEKDKEDILqWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHA-KSILLISKVENQEGLDNFDDILAESD 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 239 GIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKG 318
Cdd:PLN02461 260 AFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETAAG 339

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 319 KYPLEAVNIMATICERTDrvmpSRID------TLNDRRKLRIT--EAVCRGAVETAEKLDAPLIVVATSGGKSAKSVRKY 390
Cdd:PLN02461 340 AYPELAVKTMARICREAE----ASLDygalfkEIMRSAPLPMSplESLASSAVRTANKVKASLIVVLTRGGTTARLVAKY 415

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 983069628 391 FPNAVILA-----LTT--------NETTAHQLVLSKGVIPQMVKEIA------STDDFYRIGKEAALASGLAQKGDVVV 450
Cdd:PLN02461 416 RPAVPILSvvvpeITTdsfdwscsDEAPARHSLIYRGLIPVLAEGSAkatdseSTEEILEAAIEHAKKKGLCKPGDSVV 494
PRK06247 PRK06247
pyruvate kinase; Provisional
 2-470 6.78e-159

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 458.62  E-value: 6.78e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628   2 KKTKIVCTIGPKTESEEMLTNLLNAGMNVMRLNFSHGDYEEHGNRIKNMRAVMAKTGINAGILLDTKGPEIRTMKLEGGK 81
Cdd:PRK06247   5 RRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFADGK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  82 dASLVAGQTFTFTTDQsVIGNSDRVAVTYAGFAADLKIGNTVLVDDGLIGMEVTNVTENEVICKVLNNGDLGENKGVNLP 161
Cdd:PRK06247  85 -VQLANGQTFRLDVDD-APGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVSLP 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 162 GVSIQLPALAEKDKRDLIFGCEQGVDFVAASFIRKRSDVLEIREHLkahgGEQIQIISKIENQEGLNNFDEILEASDGIM 241
Cdd:PRK06247 163 GTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKII----GGRVPVMAKIEKPQAIDRLEAIVEASDAIM 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 242 VARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKYP 321
Cdd:PRK06247 239 VARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYP 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 322 LEAVNIMATICERTDR--VMPSRIDTLNDRRKLRITEAVCRGAVETAEKLDAPLIVVATSGGKSAKSVRKYFPNAVILAL 399
Cdd:PRK06247 319 VEAVRTMARIIRQVERdpTYPPLIHAQRPQPEATKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPILAL 398

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 983069628 400 TTNETTAHQLVLSKGVIPQMVKEIASTDDFYRIGKEAALASGLAQKGDVVVMVSGalVP---SGTTNTASVHVL 470
Cdd:PRK06247 399 TPNPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAG--VPpgtPGSTNMLRIAYI 470
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 2-467 6.90e-159

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 460.00  E-value: 6.90e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628   2 KKTKIVCTIGPKTESEEMLTNLLNAGMNVMRLNFSHGDYEEHGNRIKNMRAVMAKT-GINAGILLDTKGPEIRTMKLEGG 80
Cdd:PTZ00066  38 KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAKARpNANLGILLDTKGPEIRTGFLKNH 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  81 KDASLVAGQTFTFTTDQSVIGNSDRVAVTYAGFAADLKIGNTVLVDDGLIGMEVTNVTENEVICKVLNNGDLGENKGVNL 160
Cdd:PTZ00066 118 KPITLKEGQTLKITTDYTFLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERKNMNL 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 161 PGVSIQLPALAEKDKRDLI-FGCEQGVDFVAASFIRKRSDVLEIREHLKAHGgEQIQIISKIENQEGLNNFDEILEASDG 239
Cdd:PTZ00066 198 PGVKVELPVIGEKDKNDILnFAIPMGCDFIALSFVQSADDVRLCRQLLGERG-RHIKIIPKIENIEGLINFDEILAESDG 276

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 240 IMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGK 319
Cdd:PTZ00066 277 IMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETANGK 356

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 320 YPLEAVNIMATICERTD-----RVMPSRIDTLNDrRKLRITEAVCRGAVETAEKLDAPLIVVATSGGKSAKSVRKYFPNA 394
Cdd:PTZ00066 357 FPVEAVNIMAKICFEAEtcidyRVLYHAIHLAVP-TPVSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKYRPSC 435

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 983069628 395 VILALTTNETTAHQLVLSKGVIPQMVKEIASTDDFYRIGKEAALASGLAQKGDVVVMVSGALVP-SGTTNTASV 467
Cdd:PTZ00066 436 TILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEvAGSSNLMKV 509
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 28-452 1.53e-128

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 380.55  E-value: 1.53e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  28 MNVMRLNFSHGDYEEHGNRIKNMRAVMAKTGINAGILLDTKGPEIRTMKLEGGkDASLVAGQTFTFTTDQSV--IGNSDR 105
Cdd:PTZ00300   1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGG-EAVMERGATCYVTTDPAFadKGTKDK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 106 VAVTYAGFAADLKIGNTVLVDDGLIGMEV-TNVTENEVICKVLNNGDLGENKGVNLPGVSIQLPALAEKDKRDLIFGCEQ 184
Cdd:PTZ00300  80 FYIDYQNLSKVVRPGGYIYIDDGILILHVqSHEDEQTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQ 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 185 GVDFVAASFIRKRSDVLEIREHLKAHGGEqIQIISKIENQEGLNNFDEILEASDGIMVARGDLGVEIPVEEVIFAQKMMI 264
Cdd:PTZ00300 160 GVDMIFASFIRSAEQVGEVRKALGAKGGD-IMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILI 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 265 EKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKYPLEAVNIMATICERTDRVMPSRId 344
Cdd:PTZ00300 239 SKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEYV- 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 345 TLNDRRKLR-----ITEAVCRGAVETAEKLDAPLIVVATSGGKSAKSVRKYFPNAVILALTTNETTAHQLVLSKGV---- 415
Cdd:PTZ00300 318 FFNSIKKLQpipmsAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVesvf 397

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 983069628 416 -IPQMVKEIASTDDFYRIGKEAALASGLAQKGDVVVMV 452
Cdd:PTZ00300 398 fDAERLGHDEGKEQRVAMGVGFAKSKGYVQSGDLMVVV 435
PLN02623 PLN02623
pyruvate kinase
 2-462 1.63e-113

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 346.15  E-value: 1.63e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628   2 KKTKIVCTIGPKTESEEMLTNLLNAGMNVMRLNFSHGDYEEHGNRIKNMRAVMAKTGINA-GILLDTKGPEIRTMKLEgg 80
Cdd:PLN02623 110 RKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQSKDNViAIMLDTKGPEVRSGDLP-- 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  81 KDASLVAGQTFTFTTDQSViGNSDRVAVTYAGFAADLKIGNTVLVDDGLIGMEVTNVTENEVICKVLNNGDLGENKGVNL 160
Cdd:PLN02623 188 QPIMLEEGQEFTFTIKRGV-STEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRHLNV 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 161 PGVSIQLPALAEKDKRDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGEqIQIISKIENQEGLNNFDEILEASDGI 240
Cdd:PLN02623 267 RGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNAD-IHVIVKIESADSIPNLHSIITASDGA 345

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 241 MVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKY 320
Cdd:PLN02623 346 MVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKF 425

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 321 PLEAVNIMATICERTDRVMPSRID--TLNDRRKLRITEAVCRGAVETAEKLDAPlIVVATSGGKSAKSVRKYFPNAVILA 398
Cdd:PLN02623 426 PLKAVKVMHTVALRTEATLPEGTTppNLGQAFKNHMSEMFAFHATMMANTLGTS-IIVFTRTGFMAILLSHYRPSGTIFA 504

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 983069628 399 LTTNETTAHQLVLSKGVIPQMVKEIASTDDFYRIGKEAALASGLAQKGDVVvmvsgALVPSGTT 462
Cdd:PLN02623 505 FTNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEV-----ALVQSGRQ 563
PLN02765 PLN02765
pyruvate kinase
 4-450 1.67e-112

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 341.65  E-value: 1.67e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628   4 TKIVCTIGPKTESEEMLTNLLNAGMNVMRLNFSHGDYEEHGNRIKNMRAVMAKTGINAGILLDTKGPEIRTMKlEGGKDA 83
Cdd:PLN02765  30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVIN-KTEKPI 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  84 SLVAGQTFTFTTDQSVIGNSDRVAVTYAGFAADLKIGNTVLVDDGL--------IGMEVTNVTENEVICKVLNNGDL-GE 154
Cdd:PLN02765 109 SLKAGNTVTLTPDQSKEASSEVLPINFPGLAKAVKPGDTIFVGQYLftgsettsVWLEVDEVKGDDVVCTVKNSATLaGS 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 155 NKGVNLPGVSIQLPALAEKDKRDL-IFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGEQIQIISKIENQEGLNNFDEI 233
Cdd:PLN02765 189 LFTLHVSQVRIDLPTLSEKDKEVIsTWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLSQTQIFAKIENVEGLTHFDEI 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 234 LEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITaTQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSG 313
Cdd:PLN02765 269 LQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGADAILLGA 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 314 ESAKGKYPLEAVNIMATICERTDRVMpsriDTLNDRRK--------LRITEAVCRGAVETAEKLDAPLIVVATSGGKSAK 385
Cdd:PLN02765 348 ETLRGLYPVETISTVGRICAEAEKVF----NQDLYFKKtvkyvgepMSHLESIASSAVRAAIKVKASVIIVFTSSGRAAR 423

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 386 SVRKYFPNAVILA-----LTTN--------ETTAHQLVLSKGVIPQMVKEIASTDDFYRIGkEAAL--------ASGLAQ 444
Cdd:PLN02765 424 LIAKYRPTMPVLSvviprLKTNqlkwsftgAFQARQCLIVRGLFPMLADPRHSAESTSATN-ESVLkvaldhgkAAGVIK 502


                 ....*.
gi 983069628 445 KGDVVV 450
Cdd:PLN02765 503 SHDRVV 508
PRK06739 PRK06739
pyruvate kinase; Validated
 7-338 2.63e-102

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 309.57  E-value: 2.63e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628   7 VCTIGPKTESEEMLTNLLNAGMNVMRLNFSHGDYEEHGNRIKNMRAVMAktgiNAGILLDTKGPEIRTMKLEGgKDASLV 86
Cdd:PRK06739   6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDD----SIKILGDVQGPKIRLGEIKG-EQITLQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  87 AGQTFTFTTdQSVIGNSDRVAVTYAGFAADLKIGNTVLVDDGLIGMEVTNVTENEVICKVLNNGDLGENKGVNLPGVSIQ 166
Cdd:PRK06739  81 AGDSFILHT-QPVTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIVR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 167 LPALAEKDKRDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGEQIQIISKIENQEGLNNFDEILEASDGIMVARGD 246
Cdd:PRK06739 160 LPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSPNLIAKIETMEAIENFQDICKEADGIMIARGD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 247 LGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKYPLEAVN 326
Cdd:PRK06739 240 LGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVS 319

                        330
                 ....*....|..
gi 983069628 327 IMATICERTDRV 338
Cdd:PRK06739 320 TLRLVSEFAEHV 331
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 1-470 1.47e-99

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 307.83  E-value: 1.47e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628   1 MKKTKIVCTIGPKTESEEMLTNLLNAGMNVMRLNFSHGDYEEHGNRIKNMRAVMAKTGINAGILLDTKGPEIRTMKLEGG 80
Cdd:PLN02762  24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDLGGA 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  81 KDASLVAGQTFTFTTDQSVIGNSDR-VAVTYAGFAADLKIGNTVLVDDGLIGMEVTNVTENEVICKVLN----------- 148
Cdd:PLN02762 104 SSAKAEDGEEWTFTVRKFDGSRPEFtIQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKIGPDVKCKCTDpglllpranlt 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 149 ---NGDLGENKGVNLPGVSiqlpalaEKDKRDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHG-GEQIQIISKIENQ 224
Cdd:PLN02762 184 fwrDGSLVRERNAMLPTIS-------SKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSrDSDIGVIAKIESL 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 225 EGLNNFDEILEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILD 304
Cdd:PLN02762 257 DSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQ 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 305 GTDAVMLSGESAKGKYPLEAVNIMATICERTDRVmpSRIDTLNDRRKL---------RITEAVCRGAVETAEKLDAPLIV 375
Cdd:PLN02762 337 RADALMLSGESAMGLYPEKALSVLRSVSLRMELW--SREEKRHEALELpqlssslsdRISEEICNSAAKMANNLGVDAIF 414

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 376 VATSGGKSAKSVRKYFPNAVILALTTNETTAHQLVLSKGVIPQMVKEiaSTDDFYRIGKEAAL--ASGLAQKGDVVVMVS 453
Cdd:PLN02762 415 VYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDF--SDDMESNLNKTFSLlkARGMIKSGDLVIAVS 492

                        490
                 ....*....|....*..
gi 983069628 454 GaLVPSGTTNTASVHVL 470
Cdd:PLN02762 493 D-LTPSSMLQSIQVRNV 508
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
266-469 6.22e-53

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 180.87  E-value: 6.22e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 266 KCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKYPLEAVNIMATICERTDRVMPSR--I 343
Cdd:COG3848    1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYReqR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 344 DTLNDRRKLRITEAVCRGAVETAEKLDAPLIVVATSGGKSAKSVRKYFPNAVILALTTNETTAHQLVLSKGVIPQMVKEI 423
Cdd:COG3848   81 VPRAKESSTTITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEES 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 983069628 424 ASTDDFYRIGKEAALASGLAQKGDVVVMVSGALVP-SGTTNTASVHV 469
Cdd:COG3848  161 ASTDEMFAVAVALALEAGLVKDGDLVVITAGVPVGvSGTTNLLKVHV 207
PRK08187 PRK08187
pyruvate kinase; Validated
 23-337 1.60e-48

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 173.66  E-value: 1.60e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  23 LLNAGMNVMRLNFSHGDYEEHGNRIKNMRAVMAKTGINAGILLDTKGPEIRTMKLEGG-KDASLVAGQTFTFTTDQSVIG 101
Cdd:PRK08187 155 LAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGAVAGPlGKTRLYTGDRLALVAQGPPRR 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 102 NSD---RVAVTYAGFAADLKIGNTVLVDDGLIGMEVTNVTENEVICKVLNNGDLGE----NKGVNLPGVSIQLPALAEKD 174
Cdd:PRK08187 235 IDEehfQVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALLEVTHARPKGLklkpEKGLNFPDTALDLPALTEKD 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 175 KRDLIFGCEQGvDFVAASFIRKRSDVLEIREHLKAHGGE---QIQIISKIENQEGLNNFDEILEASDG-----IMVARGD 246
Cdd:PRK08187 315 RADLDFVARHA-DLVGYSFVQSPGDVEALQAALAARRPDdwrKLGLVLKIETPRAVANLPELIVQAAGrqpfgVMIARGD 393

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 247 LGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAilDGTDAVMLSgesaKGKYPLEAVN 326
Cdd:PRK08187 394 LAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAMA--ARAECVMLN----KGPYLVEAVT 467

                        330
                 ....*....|.
gi 983069628 327 IMATICERTDR 337
Cdd:PRK08187 468 FLDDLLARMDG 478
PRK14725 PRK14725
pyruvate kinase; Provisional
 101-337 6.92e-44

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 162.81  E-value: 6.92e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 101 GNSDRVAVTYAGFAADLKIGNTVLVDDGLIGMEVTNVTENEVICKVLNNGDLGEN----KGVNLPGVSIQLPALAEKDKR 176
Cdd:PRK14725 357 APPARISCTLPEAFRAARVGERVWFDDGKIGAVVVKVEADEVELRITHARPGGSKlkagKGINLPDSHLPLPALTDKDLE 436

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 177 DLIFGCEQGvDFVAASFIRKRSDVLEIREHLKAHGGEQIQIISKIENQEGLNNFDEI-LEA----SDGIMVARGDLGVEI 251
Cdd:PRK14725 437 DLAFVAKHA-DIVALSFVRSPEDVRLLLDALEKLGADDLGVVLKIETRRAFENLPRIlLEAmrhpRFGVMIARGDLAVEV 515

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628 252 PVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILdgTDAVMLSgesaKGKYPLEAVNIMATI 331
Cdd:PRK14725 516 GFERLAEVQEEILWLCEAAHVPVIWATQVLESLAKKGLPSRAEITDAAMALR--AECVMLN----KGPHIVEAVRVLDDI 589


                 ....*.
gi 983069628 332 CERTDR 337
Cdd:PRK14725 590 LRRMEE 595
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 356-468 1.40e-33

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 122.59  E-value: 1.40e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983069628  356 EAVCRGAVETAEKLDAPLIVVATSGGKSAKSVRKYFPNAVILALTTNETTAHQLVLSKGVIPQMVKEIASTDDFYRIGKE 435
Cdd:pfam02887   1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVK 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 983069628  436 AALASGLAQKGDVVVMVSG-ALVPSGTTNTASVH 468
Cdd:pfam02887  81 VAKEAGLVKKGDLVVITAGvPFGVSGTTNTLKVI 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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