|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
23-470 |
2.28e-85 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 270.45 E-value: 2.28e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 23 IVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACG 102
Cdd:PRK10504 14 IVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 103 LSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINIPL 182
Cdd:PRK10504 94 LSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 183 GAVGlALVARFIPGDREADPKPLDWPGFFLTSAGLALLLYGLEriAHPEDGVLPTAL--LIVAGIVLGWLAVRHLRRAPH 260
Cdd:PRK10504 174 GIIG-AIATLMLMPNYTMQTRRFDLSGFLLLAVGMATLTLALD--GSKGLGLSPLAIagLVAVGVVALLLYLLHARNNNR 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 261 PLLDLSSFKVLTFAIStLAAGTIFRVAINATPFLLPLLFQVGFGLSPVDAGLMILAYFLGNLGMKTVTTPTLRRFGFRSV 340
Cdd:PRK10504 251 ALFSLKLFRTRTFSLG-LAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRV 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 341 MVVNGIIASASIMACGAISPQTPQALVVALMLIAGLSRSMQFTALNTLAFADIDASQRSSAATLSSMLQQVAMLFGVAVA 420
Cdd:PRK10504 330 LVATTLGLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIA 409
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 1017221224 421 AAILNL---SQIVRDRPALDLVdFRVAFLAIGAIGLVAALRFLVLPPGAGAEV 470
Cdd:PRK10504 410 GLLLGLfgqQHVSVDSGATHTV-FMYTYLCMALIIALPALIFARVPNDTHQNV 461
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
24-463 |
5.77e-77 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 245.95 E-value: 5.77e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 24 VAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGL 103
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 104 SQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINIPLG 183
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 184 AVGLALVarfipgdreadpkpldwpgffltsaglalllygleriahpedgvlptallivagivlgwlavrhlrraphPLL 263
Cdd:cd17503 161 ILALLLA----------------------------------------------------------------------PLL 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 264 DLSSFKVLTFAISTLaAGTIFRVAINATPFLLPLLFQVGFGLSPVDAGLMILAYFLGNLGMKTVTTPTLRRFGFRSVMVV 343
Cdd:cd17503 171 DLRLFKDRNFTLGLL-LSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLA 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 344 NGIIASASIMACGAISPQTPQALVVALMLIAGLSRSMQFTALNTLAFADIDASQRSSAATLSSMLQQVAMLFGVAVAAAI 423
Cdd:cd17503 250 GLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATL 329
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 1017221224 424 LNL-----------SQIVRDRPALDLVDFRVAFLAIGAIGLVAALRFLVLP 463
Cdd:cd17503 330 LTNrtqfhhsrlseLLAQQVQKQALIIAFNDAFLVSAILLLVGLLLALFLR 380
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
19-424 |
8.14e-56 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 193.36 E-value: 8.14e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 19 RVALIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLAS 98
Cdd:TIGR00711 2 LLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 99 LACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFI 178
Cdd:TIGR00711 82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 179 NIPLGAVGLALVARFIPGDREADPKPLDWPGFFLTSAGLALLLYGLERiaHPEDG------VLPTALLIVAGIVLgwLAV 252
Cdd:TIGR00711 162 NVPIGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSE--GPERGwfdsneILILSITGLVAIIA--FVV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 253 RHLrRAPHPLLDLSSFKVLTFAISTLAAgTIFRVAINATPFLLPLLFQVGFGLSPVDAGLMILAYFLGNLGMKTVTTPTL 332
Cdd:TIGR00711 238 WEL-TDDNPLVDLRLFKYRNFTIGCVYM-SLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 333 RRFGFRSVMVVN-GIIASASIMACGAISPQTPQALVVALMLIAGLSRSMQFTALNTLAFADIDASQRSSAATLSSMLQQV 411
Cdd:TIGR00711 316 DKIDPRKLVTIGlILYAVGFYWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQL 395
|
410
....*....|...
gi 1017221224 412 AMLFGVAVAAAIL 424
Cdd:TIGR00711 396 GGSIGTALITTIL 408
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
24-463 |
1.27e-44 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 160.42 E-value: 1.27e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 24 VAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGL 103
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 104 SQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINIPLG 183
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 184 AVGLALVARFIPGdreadpkpldwpgffltsaglalllygleriahpedgvlptallivagivlgwlavrhlrraphpll 263
Cdd:cd17321 161 LVALLLARTFSGA------------------------------------------------------------------- 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 264 dlssfkVLTFAISTLAAGTIFrvainatpFLLPLLFQVGFGLSPVDAGLMILAYFLGNLGMKTVTTPTLRRFGFRSVMVV 343
Cdd:cd17321 174 ------VLAAFLLGAALGGLL--------FLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVA 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 344 NGIIASASIMACGAISPQTPQALVVALMLIAGLSRSMQFTALNTLAFADIDASQRSSAATLSSMLQQVAMLFGVAVAAAI 423
Cdd:cd17321 240 GLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 1017221224 424 L--NLSQIVRDRPALDLVD---------FRVAFLAIGAIGLVAALRFLVLP 463
Cdd:cd17321 320 LtaGLSANLGDSGVAALLSaaaaafaagFHLAFLVAAALALLAALLALLLP 370
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
24-422 |
9.39e-37 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 138.08 E-value: 9.39e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 24 VAIAFFMQLLDSTIISTSLPQMGASFGvSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGL 103
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 104 SQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINIPLG 183
Cdd:cd17502 80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 184 AVGLALVarfipgdreadpkpldwPGFFLTSaglalllygleriahpedgvlpTALLIVAGIVLGWLavrhlrraphpll 263
Cdd:cd17502 160 GLALALL-----------------RTILLSS----------------------IFGFLFGGALFGLI------------- 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 264 dlssfkvltfaistlaagtifrvainatpFLLPLLFQVGFGLSPVDAGLMILAYFLGNLGMKTVTTPTLRRFG-FRSVMV 342
Cdd:cd17502 188 -----------------------------YYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLIV 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 343 VNGIIASASIMACGAISPQTPQALVVALMLIAGLSRSMQFTALNTLAFADIDASQRSSAATLSSMLQQVAMLFGVAVAAA 422
Cdd:cd17502 239 IGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAITDV 318
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-413 |
1.73e-34 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 132.41 E-value: 1.73e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 11 SETATHARRVALIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLA 90
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 91 IVLFTLASLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYL 170
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 171 SWHWNFFINIPLGAVGLALVARFIPGDREADPKPLdwpgffltsaglalllygleriahpedgvlptallivAGIVLGWL 250
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRPAARARL-------------------------------------RGSLRELL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 251 AVRHLRRAphplldlssfkvltfaistLAAGTIFRVAINATPFLLPLLFQVGFGLSPVDAGLMILAYFLGNLGMKTVTTP 330
Cdd:COG2814 205 RRPRLLLL-------------------LLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGR 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 331 TLRRFGFRSVMVVNGIIASASIMacgAISPQTPQALVVALMLIAGLSRSMQFTALNTLAFADIDASQRSSAATLSSMLQQ 410
Cdd:COG2814 266 LADRFGRRRLLLIGLLLLALGLL---LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFF 342
|
...
gi 1017221224 411 VAM 413
Cdd:COG2814 343 LGG 345
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
8-305 |
2.80e-29 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 116.45 E-value: 2.80e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 8 ATLSETATHARRVALIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIF 87
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 88 LLAIVLFTLASLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFIT 167
Cdd:COG0477 83 LIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 168 TYLSWHWNFFINIPLGAVGLALVARFipgdreadPKPLDWPGFFLTSAGLALLLYGLERIAHPEDGVLPTALLIVAGIVL 247
Cdd:COG0477 163 AALGWRWIFLINAPLGLLALVLRLRL--------PESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLL 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1017221224 248 GWLAVRHLRRAPHPLLDLSSFKVLTFAISTLAAGTIFRVAINATPFLLPLLFQVGFGL 305
Cdd:COG0477 235 AGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLA 292
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
24-463 |
9.05e-29 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 116.91 E-value: 9.05e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 24 VAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGL 103
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 104 SQTLTQFVAARVVQGLGSAlMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINIPLG 183
Cdd:cd17504 81 APNLPVLIAGRALQGIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 184 AVGLALVarfipgdreadpkpldwpgffltsaglalllygleriahpedgvlptallivagivlgwlavrhlrraphPLL 263
Cdd:cd17504 160 VLLAALV----------------------------------------------------------------------PLI 169
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 264 DLSSFK---VLTFAISTLAAGTIFRVAINATPFLLPLLFQVGFGLSPVDAGLMILAYFLGNLGMKTVTTPTLRRFGFRSV 340
Cdd:cd17504 170 DLRLLRrrnVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRV 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 341 MVVNGIIASASIMAcGAISPQTPQALVVALMLIaGLSRSMQFTALNTLAFADIDASQRSSAATLSSMLQQVAMLFGVAVA 420
Cdd:cd17504 250 LLIGLVISAVGLLL-LALLHSSLWALVVALLLI-GIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIA 327
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1017221224 421 AAIL-NLSQIVRDRPALDLVDFRVAFLAIGAIGLVAALRFLVLP 463
Cdd:cd17504 328 GAILtTYTVSITSGGVPTEGAYVLAFLIGAALALAALLLSLLIP 371
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
24-416 |
1.53e-25 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 107.12 E-value: 1.53e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 24 VAIAFFMQLLDSTIISTSLPQ-MGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACG 102
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 103 LSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINIPL 182
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 183 GAVGLALVARFIPgdreadpkpldwpgffltsaglalllygleriaHPEDGVLPTALLIVAGIVLGWLAVRHLRraphpl 262
Cdd:pfam07690 161 SLLAAVLLLLPRP---------------------------------PPESKRPKPAEEARLSLIVAWKALLRDP------ 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 263 ldlssfkvltfAISTLAAGTIFRVAINATPFLLPlLFQVGFGLSPVDAGLMILAYFLGNLGMKTVTTPTLRRFGFRSVMV 342
Cdd:pfam07690 202 -----------VLWLLLALLLFGFAFFGLLTYLP-LYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL 269
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1017221224 343 VNGIIASASIMACGAISPQTPQALVVALMLIAGLSRSMQFTALNTLAFADIDASQRSSAATLSSMLQQVAMLFG 416
Cdd:pfam07690 270 LALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
20-428 |
1.64e-24 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 104.97 E-value: 1.64e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 20 VALIVAIAFFMQLLDsTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASL 99
Cdd:cd17320 1 LLLLALLVALGPLAI-DMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 100 ACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFIN 179
Cdd:cd17320 80 LCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 180 IPLGAVGLALVARFIPGDREADPKpldwpgffltsaglalllygleriahpedGVLPTALLIVAGIVlgwlavrhlrrap 259
Cdd:cd17320 160 ALLGLLLLLLVLLFLPETLPEEKR-----------------------------KPLLSSLLRAYKRV------------- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 260 hplldLSSFKVLTFAISTLAAGTIFRVAINATPFllplLFQVGFGLSPVDAGLMILAYFLGNLGMKTVTTPTLRRFGFRS 339
Cdd:cd17320 198 -----LKNRRFLGYALALGLSFAGLFAYLAAAPF----IYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRR 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 340 VM--VVNGIIASASIMACGAISPQTPQALVVALMLIAGLSRSMQFTALNTLAFADIDaSQRSSAATLSSMLQQVAMLFGV 417
Cdd:cd17320 269 LLrlGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP-HVAGTASALLGFLQFLIGALAG 347
|
410
....*....|.
gi 1017221224 418 AVAAAILNLSQ 428
Cdd:cd17320 348 ALVGLLPNGTA 358
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
24-462 |
2.93e-23 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 101.11 E-value: 2.93e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 24 VAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGL 103
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 104 SQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINIPLG 183
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 184 AVGLALVARFIPGDREADPKpldwpgffltsaglalllygleriahpedgvlptallivagivlgwlAVRHLRRAPHPLL 263
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNK-----------------------------------------------RAVSAARLRSGLR 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 264 DLSSFKVLTFAISTLAAGTIFRVAINATpflLPLLFQVGFGLSPVDAGLMILAYFLGNLGMKTVTTPTLRRFGFRSVMVV 343
Cdd:cd17325 194 LLLRDRRLLALFLAIFVLAFAFGALEPF---LPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILI 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 344 nGIIASASIMACgaISPQTPQALVVALMLIAGLSRSMQFTALNTLAFADIDASQRSSAATLSSMLQQVAMLFGVAVAAAI 423
Cdd:cd17325 271 -GLLLSAVALLL--LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFL 347
|
410 420 430
....*....|....*....|....*....|....*....
gi 1017221224 424 lnlsqivrdrpaLDLVDFRVAFLAIGAIGLVAALRFLVL 462
Cdd:cd17325 348 ------------YDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
17-464 |
4.42e-22 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 97.25 E-value: 4.42e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 17 ARRVALIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTL 96
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 97 ASLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNF 176
Cdd:COG2271 88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 177 FInipLGAVGLALvarfipgdreadpkpldwpgffltsaglalllygleriahpedGVLPTALLIVAGIVLGWlavrhlr 256
Cdd:COG2271 168 LI---LGLPGLLL-------------------------------------------ALLRFWLLALAYFLVYF------- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 257 raphplldlssfkvltfaistlaagtifrvAINATPFLLPLLFQVGFGLSPVDAGLMILAYFLGNLGMKTVTTPTLRRFG 336
Cdd:COG2271 195 ------------------------------ALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLG 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 337 FRSVMVVnGIIASASIMACGAISPQTPQALVVALMLIAGLSRSMQFTALNTLAFADIDASQRSSAATLSSMLQQVAMLFG 416
Cdd:COG2271 245 RRRKLVL-AIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALG 323
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1017221224 417 VAVAAAIlnlsqivrdrpaLDLVDFRVAFLAIGAIGLVAALRFLVLPP 464
Cdd:COG2271 324 PLLVGYL------------LDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
33-427 |
1.18e-21 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 97.49 E-value: 1.18e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 33 LDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGLSQTLTQFVA 112
Cdd:PRK14995 20 IDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 113 ARVVQGLGSALMTPvGRILVLRNAPKSELLNATALITWPAL--FAPVVGPVLGGFITTYLSWHWNFFINIPLGAVGLALV 190
Cdd:PRK14995 100 TRALLAIGAAMIVP-ATLAGIRATFTEEKQRNMALGVWAAVgsGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLT 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 191 ARFIPGDREADPKPLDWPGFFLTSAGLALLLYGLERIAHPEDGVLPTALLIVAGIVLGWLAVRHLRRAPHPLLDLSSFKV 270
Cdd:PRK14995 179 ARYVPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRLFTH 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 271 LTFAISTLAAGTIFrVAINATPFLLPLLFQVGFGLSPVDAGLMILAYFLGNLGMKTVTTPTLRRFGFRSVMVVNGIIASA 350
Cdd:PRK14995 259 RIILSGVVMAMTAM-ITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVATGGMALSAL 337
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1017221224 351 SIMACGAISPQTPQALVVALMLIAGLSRSMQFTALNTLAFADIDASQRSSAATLSSMLQQVAMLFGVAVAAAILNLS 427
Cdd:PRK14995 338 SFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGLGIAIFGLLLSRS 414
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
23-457 |
1.27e-21 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 96.10 E-value: 1.27e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 23 IVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACG 102
Cdd:cd17474 3 AVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 103 LSQTLTQFVAARVVQGLGSALMTP-----VGRILVLRNAPKSELLNATALItwpalFAPVVGPVLGGFITTYlSWHWNFF 177
Cdd:cd17474 83 LSDSFALLLAGRALQGIGAAGLGPlaltlIGDLFEGGERAKAMGLYEAALG-----LGIAVGPLLGGLLAAI-SWRYPFF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 178 INIPLGAVGLALVARFIPGDREADPKPldwpgffltsaglalllygleriahpedgvlptallivagivlGWLAVRHLRR 257
Cdd:cd17474 157 LLAALIPVAFLAILFLLPEPKEKAKSS-------------------------------------------SATKLRDLKK 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 258 AphplldLSSFKVLTFAISTLAAGTIFRVAINATPFLLPLLFQV-----GFGLSPVDAGLMILAYFLGNLgmktvttpTL 332
Cdd:cd17474 194 A------LRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGIspiiiGLLFAGWSVLLALGSLFVGRL--------LK 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 333 RRFGFRSVMVVNGIIASASImacGAISPQTPQALVVALMLIAGLSRSMQFTALNTLAFADIDASQRSSAATLSSMLQQVA 412
Cdd:cd17474 260 KRFGARRILVIGLLLYALSL---LLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLG 336
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 1017221224 413 MLFGVAVAAAILNLSqivrdrpaldlvDFRVAFLAIGAIGLVAAL 457
Cdd:cd17474 337 QAVGPLLFGLLLEIF------------GLSAPFLVGAAIALAAAV 369
|
|
| MFS_effux_SdrM |
NF040895 |
multidrug efflux MFS transporter SdrM; |
20-315 |
1.52e-21 |
|
multidrug efflux MFS transporter SdrM;
Pssm-ID: 468830 [Multi-domain] Cd Length: 441 Bit Score: 96.96 E-value: 1.52e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 20 VALIVAIafFMQLLDSTIISTSLPQMGASFGVSPvAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASL 99
Cdd:NF040895 9 VALVLIM--FMAAIETSIISLALPTIKEDLNAGS-SISLVFTVYFIALVIANPIVGELLSRFKIIYITILGLLLFIIGSL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 100 ACGLSQTLTQFVAARVVQGLGSALMTPVGRIlVLRNA---PKSELLNATALITWPalFAPVVGPVLGGFITTYLSWHWNF 176
Cdd:NF040895 86 MSGLSETFTMLIISRIIQGLGAGVMMSLSQI-VPKLAfeiPLRYKIMGIVGSVWG--ISSIIGPLLGGGILEFATWHWLF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 177 FINIPLG--AVGLALVARFIPGDREADPKPLDWPGFFLTSAGLALLLYGLERIAHpedgVLPTALLIVAGIVLGWLAVRH 254
Cdd:NF040895 163 FINIPIAiiAIILVIFTFHFPEEETTSKTKFDVKGLTLFYIFIALLMFAVLNQGH----LWLNIISFILAIVVFFLLFKV 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1017221224 255 LRRAPHPLLDLSSFKVLTfaisTLAAGTIFRVAINATPFLL--PLLFQVGFGLSPVDAGLMIL 315
Cdd:NF040895 239 EKKVKNPFLPVKEFNKSI----ILVFFTDFLIAMMLMGYNLyiPIYLQEHLGLSPLQSGLVIF 297
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
18-190 |
1.56e-20 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 92.63 E-value: 1.56e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 18 RRVALIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLA 97
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 98 SLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFF 177
Cdd:cd17319 82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFI 161
|
170
....*....|...
gi 1017221224 178 InipLGAVGLALV 190
Cdd:cd17319 162 I---EGLLGLLLA 171
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
22-195 |
2.67e-19 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 89.56 E-value: 2.67e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 22 LIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLAC 101
Cdd:cd17323 2 FIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 102 GLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINIP 181
Cdd:cd17323 82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAI 161
|
170
....*....|....
gi 1017221224 182 LGAVGLALVARFIP 195
Cdd:cd17323 162 ISGFCLILIFLFLP 175
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
22-205 |
2.74e-19 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 89.15 E-value: 2.74e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 22 LIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLAC 101
Cdd:cd17324 2 LALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 102 GLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINIP 181
Cdd:cd17324 82 ALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161
|
170 180
....*....|....*....|....
gi 1017221224 182 LGAVGLALVARFIPGDREADPKPL 205
Cdd:cd17324 162 LALLAALLLWRLLPSLPPKKPGSL 185
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
17-195 |
3.49e-19 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 89.37 E-value: 3.49e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 17 ARRVALIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTL 96
Cdd:TIGR00710 3 AKAFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 97 ASLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNF 176
Cdd:TIGR00710 83 SSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIF 162
|
170
....*....|....*....
gi 1017221224 177 FINIPLGAVGLALVARFIP 195
Cdd:TIGR00710 163 AFLSLAGILLSALIFFILP 181
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
57-195 |
7.95e-18 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 80.00 E-value: 7.95e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 57 SIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNA 136
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1017221224 137 PKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINIPLGAVGLALVARFIP 195
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
41-195 |
1.69e-17 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 84.20 E-value: 1.69e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 41 SLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGLSQTLTQFVAARVVQGLG 120
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1017221224 121 SALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINIPLGAVGLALVARFIP 195
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIP 167
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
22-193 |
3.46e-16 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 80.00 E-value: 3.46e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 22 LIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLAC 101
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 102 GLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLN-ATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINI 180
Cdd:cd17476 81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNiVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLA 160
|
170
....*....|...
gi 1017221224 181 PLGAVgLALVARF 193
Cdd:cd17476 161 ILAAI-VAVAAIF 172
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
26-199 |
7.27e-16 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 79.30 E-value: 7.27e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 26 IAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGLSQ 105
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 106 TLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINIPLGAV 185
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGII 160
|
170
....*....|....
gi 1017221224 186 GLALVARFIPGDRE 199
Cdd:TIGR00893 161 WGVLWLKFIPDPPQ 174
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
17-457 |
1.34e-15 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 78.38 E-value: 1.34e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 17 ARRVALIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTL 96
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 97 ASLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNF 176
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 177 FINIPLGAVGLALVARFIPGDREADPKPldwpgffltsaglalllygleriahpedgvlptalliVAGIVLGWLAVrhlr 256
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRDPPAGAAAA-------------------------------------AKASLRDQLEA---- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 257 raphplldLSSFKVLTFAISTLAAGTIFRVAINAtpflLPLLFQVGFGLSPVDAGLMILAYFLGNLGMKTVTTPTLRRFG 336
Cdd:COG2223 202 --------LRDPRFWLLSLLYFGTFGSFIGFSSW----LPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIG 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 337 FRSVMVVNGIIASASIMAcgAISPQTPQALVVALMLIAGLSRSMQFTALNTLAFADIDASQRSSAATLSSMLQQVAMLFG 416
Cdd:COG2223 270 GRRVLLIVFALMALGLLL--LALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLG 347
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 1017221224 417 VAVAAAILNLSQivrdrpaldlvDFRVAFLAIGAIGLVAAL 457
Cdd:COG2223 348 PLLFGALLDATG-----------SYTAAFLVFAVLALVALV 377
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
19-195 |
1.59e-14 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 75.09 E-value: 1.59e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 19 RVALIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLAS 98
Cdd:TIGR00895 17 RAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 99 LACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSelLNATALITWPALFApvVGPVLGGFITTYL----SWHW 174
Cdd:TIGR00895 97 LLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKR--FRGTAVGLMFCGYP--IGAAVGGFLAGWLipvfGWRS 172
|
170 180
....*....|....*....|.
gi 1017221224 175 NFFINIPLGAVGLALVARFIP 195
Cdd:TIGR00895 173 LFYVGGIAPLLLLLLLMRFLP 193
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
11-195 |
2.86e-14 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 74.59 E-value: 2.86e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 11 SETATHARRVALIVAIAF----FMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNI 86
Cdd:PRK15402 1 LSPLARLGRQALLFPLCLvlfeFATYIANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 87 FLLAIVLFTLASLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFI 166
Cdd:PRK15402 81 MLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAAL 160
|
170 180
....*....|....*....|....*....
gi 1017221224 167 TTYLSWHWNFFINIPLGAVGLALVARFIP 195
Cdd:PRK15402 161 IHVLPWRGMFVLFAALAALSFFGLWRAMP 189
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
36-463 |
1.31e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 72.22 E-value: 1.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 36 TIISTSLPQMGASF-GVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGLSQTLTQFVAAR 114
Cdd:cd17473 16 AAIAPALPAIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 115 VVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTyLSWHWNFFINIpLGAVGLALVARFI 194
Cdd:cd17473 96 ALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL-LALPVLILVLLFL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 195 PGDREADpkpldwpgffltsaglalllygleriahpedgvlptallivagivlgwlaVRHLRRAPHPLLDLSSFKVLTFA 274
Cdd:cd17473 174 PEPARKS--------------------------------------------------KSAASPGAATAAALPWKRVLPIY 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 275 ISTLAAGTIFRVAINATPFLLPLLFQVGFGLSPVDAGLMILAYFLGNLGMKTVttptLRRFGFRSVMVVNGIIASASIMA 354
Cdd:cd17473 204 FLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRL----KRRLGKRRLLAIGFALMALGFLL 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 355 CGAISpqtPQALVVALMLIAGLSRSMQFTALNTLAFADIDASQRSSAATLSSMlqqvAMLFGVAVAAAILNLSqivrdrp 434
Cdd:cd17473 280 LALAS---GLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTS----AFFLGQFLSPLVLGPL------- 345
|
410 420
....*....|....*....|....*....
gi 1017221224 435 ALDLVDFRVAFLAIGAIGLVAALRFLVLP 463
Cdd:cd17473 346 VNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
28-172 |
3.20e-13 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 71.21 E-value: 3.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 28 FFMQLLDSTIIS---TSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGLS 104
Cdd:PRK10473 9 FALVLLYPAGIDmylVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLA 88
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1017221224 105 QTLTQFVAARVVQGLGSALMTPVGrILVLRNA-PKSELLNATALITWPALFAPVVGPVLGGFITTYLSW 172
Cdd:PRK10473 89 ETSSLFLAGRFLQGIGAGCCYVVA-FAILRDTlDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPW 156
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
24-460 |
6.71e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 70.15 E-value: 6.71e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 24 VAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGL 103
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 104 SQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYL--SWHWNFFINIP 181
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 182 LGAVGLALVARFIPGDREADPKPLDWpgffltsaglalllygleriahpedgvlptallivagivlgwlaVRHLRRAPHP 261
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEE--------------------------------------------ASSKSVLKLL 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 262 LLDLSSFKVLTFAISTLAAGTIFrvaiNATPFLLPLLFQVGFGLSPVDAGLMILAYFLGNLGMKTVTTPTLRRFGFRSVM 341
Cdd:cd06174 197 KRVLKNPGLWLLLLAIFLVNLAY----YSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPL 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 342 VVNGIIASASIMACGAISPQTPqaLVVALMLIAGLSRSMQFTALNTLAFADIDASQRSSAATLSSMLQQVAMLFGVAVAA 421
Cdd:cd06174 273 LLIGLLLMALGLALLLLAPSLL--LLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAG 350
|
410 420 430
....*....|....*....|....*....|....*....
gi 1017221224 422 AILNLSQivrdrpaldlvDFRVAFLAIGAIGLVAALRFL 460
Cdd:cd06174 351 FLLAATF-----------GLTGAFLVLAVLLLLAAILLL 378
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
36-203 |
1.83e-12 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 68.78 E-value: 1.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 36 TIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGLSQTLTQFVAARV 115
Cdd:PRK11652 25 TIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 116 VQGLGsalmTPVGRILVlRNAPK-----SELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINIPLGAVGLALV 190
Cdd:PRK11652 105 IQGLG----TGVGGVMA-RTLPRdlyegTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSM 179
|
170
....*....|...
gi 1017221224 191 ARFIPGDREADPK 203
Cdd:PRK11652 180 ARWMPETRPADAR 192
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
24-195 |
2.05e-12 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 68.80 E-value: 2.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 24 VAIAFFMQLL---DSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLA 100
Cdd:cd17328 1 VAVLFLINLLnymDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 101 CGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTY-LSWHWNFFIN 179
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVT 160
|
170
....*....|....*.
gi 1017221224 180 IPLGAVGLALVARFIP 195
Cdd:cd17328 161 GVLGVLLAILLLLFVR 176
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
52-457 |
3.15e-12 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 68.03 E-value: 3.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 52 SPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNI-----FLLAIVLFTLASLACGLSQTLTQFVAARVVQGLGSALMTP 126
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 127 VGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINIpLGAVGLALVARFIPGDREADPKPld 206
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA-LSFLLSALLLLFIRRPPPAAPGE-- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 207 wpgffltsaglalllygleriahpedgvlPTALLIVAGIVLGWLAVRHLRRAPhplldlssfkvltfaisTLAAGTIFRV 286
Cdd:cd06173 189 -----------------------------SSSLLLRDLREGLRYLRRSPLLRL-----------------LLLALALFAL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 287 AINATPFLLPLLFQVGFGLSPVDAGLMILAYFLGNLGMKTVTTPTLRRFGFRSVMVVNGIIASASIMACGAIspqTPQAL 366
Cdd:cd06173 223 LGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLS---PSLWL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 367 VVALMLIAGLSRSMQFTALNTLAFADIDASQRSSAATLSSMLQQVAMLFGVAVAAAilnlsqivrdrpALDLVDFRVAFL 446
Cdd:cd06173 300 LLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGL------------LADALGLSAVFL 367
|
410
....*....|.
gi 1017221224 447 AIGAIGLVAAL 457
Cdd:cd06173 368 LAGALLLLAAL 378
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
25-195 |
4.93e-12 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 67.33 E-value: 4.93e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 25 AIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGLS 104
Cdd:cd17371 5 FLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 105 QTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALIT--WPA--LFAPVVGPVLGGFITTYLSWHWNFFINI 180
Cdd:cd17371 85 QNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQsgWAVgwLLATLLAALLFPLLPPEIAWRVLFLLGA 164
|
170
....*....|....*
gi 1017221224 181 pLGAVGLALVARFIP 195
Cdd:cd17371 165 -LPALLVLFIRRFVK 178
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
22-425 |
7.71e-12 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 67.27 E-value: 7.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 22 LIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIgITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLAC 101
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPSSNSTWI-STAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 102 GLSQTLTQFVAARVVQGLGSALmTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFIT--TYLSWHWNFFIN 179
Cdd:cd06179 80 GTAKSVNMLIGGQALIGIGAGT-QGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVeaNAAGWRWIFYIN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 180 IPLGAVGLALVARFI-PGDREAD--------PKPLDWPGFFL--TSAGLALLLYGLERIAHPEDGVLPTALLIVAGIVLG 248
Cdd:cd06179 159 AIFNALALILLFFFYhPPPRPQLhgsstrqkLKRLDWVGLFLliAGLVLFLLGLSWGGNPYPWSSAHVIAPLVIGGVLLI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 249 WLAVRHLRRAPHPLLDLSSFK-VLTFAISTLAA---GTIFRVAINATPFLLPLLfqvgFGLSPVDAGLMILAYFLGNLGM 324
Cdd:cd06179 239 AFGLYEWKGTKDGLLPPRLLFrGRNFALILIVAfveGMIFYSLNIFWPQQISLL----FTTDPLKAGLYQLPFGLGTLFG 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 325 KTVTTPTLRRFG-FRSVMVVNGIIASASImACGAISPQTPQALVVALMLIAGLsrSMQFTALNTLAFADIDASQRSSAat 403
Cdd:cd06179 315 AILAGLLLTKIKhIKWQLVAGFVLFTAFL-ALLALITPDNKALAIAFSVLAGI--GIGGPLVLAIVIVQLSVPPEDIG-- 389
|
410 420
....*....|....*....|..
gi 1017221224 404 LSSMLQQVAMLFGVAVAAAILN 425
Cdd:cd06179 390 TASGLLGSARALGGAVGTAIFT 411
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
21-194 |
1.03e-11 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 66.09 E-value: 1.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 21 ALIVAIAFFMQLLDSTIISTSLPQMGASF--GVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLAS 98
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 99 LACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSE----LLNATALITWPALFAPVVGPVLGGFITTYLSWHW 174
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRrgfaLGLLQSGWALGALLAALVASLLIPLLSGDWGWRI 160
|
170 180
....*....|....*....|
gi 1017221224 175 NFFINIPLGAVGLALVARFI 194
Cdd:cd17316 161 LFLIGALPALLALLLRRRTL 180
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
18-194 |
3.84e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 64.52 E-value: 3.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 18 RRVALIVAIAFFMQLLDSTIISTSLPQMGAS-FGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTL 96
Cdd:cd17325 198 DRRLLALFLAIFVLAFAFGALEPFLPLYAAElGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 97 ASLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNF 176
Cdd:cd17325 278 ALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPF 357
|
170
....*....|....*...
gi 1017221224 177 FINIPLGAVGLALVARFI 194
Cdd:cd17325 358 LAAAALLLLAAVLFLLLR 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
1-204 |
4.86e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 64.51 E-value: 4.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 1 MTAIPEIATLSETATHARRVALIVAIAFFMQLLdSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADR 80
Cdd:COG2807 1 MSTTSSSARRSRRAGRWLLLLAIVLVALNLRPA-ITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 81 FGARNIFLLAIVLFTLASLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLnATALITWPALFAPVVGP 160
Cdd:COG2807 80 FGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVGL-MTGLYTAAMGLGAALAA 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1017221224 161 VLGGFITTYLSWHWNFFINIPLGAVGLALVARFIPGDREADPKP 204
Cdd:COG2807 159 GLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAA 202
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
60-195 |
7.03e-11 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 64.08 E-value: 7.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 60 ITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKS 139
Cdd:PRK15403 57 VSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQT 136
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1017221224 140 ELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINIPLGAVGLALVARFIP 195
Cdd:PRK15403 137 KGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMP 192
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
13-457 |
3.13e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 61.79 E-value: 3.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 13 TATHARRVALIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIV 92
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 93 LFTLASLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKsellNATALITWPALF---APVVGPVLGGFITTY 169
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPE----TAASRLNLLHAFfslGALLGPLLGGLLILL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 170 ---LSWHWNFFIN-IPLGAVGLALVARFIPGDREADPKPLDwpgffltsaglalllygleriahpedgvlptallivagi 245
Cdd:COG0738 158 glsLSWHLPYLILaVLLLLLALLFLRSKLPEIEEEEEEAAG--------------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 246 vlgwlavrhlrrAPHPLLDLSSFKVLTFAISTLAAGTIFRVAINATpflLPLLFQVGFGLSPVDAGLMILAYFLGNLGMK 325
Cdd:COG0738 199 ------------SAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDW---LPLYLKDVLGLSEATAALGLSLFWGGMTIGR 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 326 TVTTPTLRRFGFRSVMVVNGIIASASImaCGAISPQTPQALVVALMLIaGLSRSMQFTALNTLAfadIDASQRSSAATLS 405
Cdd:COG0738 264 FLGGFLLKRFGPVRLLRLSALLAAVGL--LLALLAPGPWLALIGLALV-GLGLSLMFPTIFSLA---LDGLGKRTAAAVS 337
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 1017221224 406 SMLqqVAMLFGVAVAAAILNLsqivrdrpALDLVDFRVAFLAIGAIGLVAAL 457
Cdd:COG0738 338 AVL--IMGIVGGAIGPPLIGF--------LADAFGLRAAFLVPLVCYLLILL 379
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
19-120 |
7.56e-10 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 60.66 E-value: 7.56e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 19 RVALIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLAS 98
Cdd:cd17359 1 LISLVAALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISA 80
|
90 100
....*....|....*....|..
gi 1017221224 99 LACGLSQTLTQFVAARVVQGLG 120
Cdd:cd17359 81 LGSAFSPNFTIFIIARIIGGLA 102
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
44-204 |
9.35e-10 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 60.29 E-value: 9.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 44 QMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGLSQTLTQFVAARVVQGLGSAL 123
Cdd:PRK11043 31 AIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 124 MTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFInipLGAVGLALVA---RFIPGDREA 200
Cdd:PRK11043 111 AAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFAT---LFAITLLLILptlRLKPSKKAR 187
|
....
gi 1017221224 201 DPKP 204
Cdd:PRK11043 188 KQSQ 191
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
22-462 |
1.22e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 59.92 E-value: 1.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 22 LIVAIAFFMQLldstiisTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLAC 101
Cdd:cd17489 6 FFFFLSFYLLL-------PVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 102 GLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINIP 181
Cdd:cd17489 79 LLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 182 LGAVGLALVA----RFIPGDREADPKPLDWPGFFLTSaglalllygleriahpedGVLPTALLIVAGIVLGwlavrhlrr 257
Cdd:cd17489 159 LALLALLLVFlvkdPPPVAAEEAEAGTRAFRRLVEKK------------------VLPPALILFLASIAYG--------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 258 aphplldlssfkvltfAISTlaagtifrvainatpfLLPLLFQVgfgLSPVDAGLMILAYFLGNLGMKTVTTPTLRRFGF 337
Cdd:cd17489 212 ----------------AIST----------------FLPLYAAE---RGISNAGLFFTVYAIALLLSRPFSGKLSDRKGP 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 338 RSVMVVNGIIASASIMACGAiSPQTPQALVVALMLiaGLSRSMQFTALNTLAFADIDASQRSSAATLSSMLQQVAMLFGV 417
Cdd:cd17489 257 KTVIIPGLLLLALGLLLLSF-AGSPWMLLLAAVLY--GLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGG 333
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 1017221224 418 AVAAAILNLSQivrdrpaldlvdFRVAFLAIGAIGLVAALRFLVL 462
Cdd:cd17489 334 LLLGLVAELFG------------YRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
49-199 |
1.60e-09 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 59.54 E-value: 1.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 49 FGVSPVAMSIGITVYMLTMAVF-VPLsGWLADRFGARNIFLLAIVLFTLASLACGLSQTLTQFVAARVVQGLGSalMTPV 127
Cdd:cd17472 27 PGATPTLIGLALGIYGLTQAIFqIPF-GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGA--ISSV 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1017221224 128 GRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINIPLGAVGLALVARFIPGDRE 199
Cdd:cd17472 104 VMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPK 175
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
24-190 |
1.80e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 59.14 E-value: 1.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 24 VAIAFFMQLLDS---TIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLA 100
Cdd:cd17365 1 LALCFLIIVLDGfdlAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 101 CGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINI 180
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG 160
|
170
....*....|
gi 1017221224 181 PLGAVGLALV 190
Cdd:cd17365 161 VPPLILLPLL 170
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
24-195 |
3.55e-08 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 55.28 E-value: 3.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 24 VAIAFFMQLLDSTIISTSLPQMGASF---GVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLA 100
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFnklGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 101 CGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLnATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINI 180
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAK-AFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159
|
170
....*....|....*
gi 1017221224 181 PLGAVGLALVARFIP 195
Cdd:cd17330 160 ALALLNLVLVLFFLP 174
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
57-463 |
1.70e-07 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 52.97 E-value: 1.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 57 SIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNa 136
Cdd:cd17317 28 ALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEI- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 137 pksellnatalitwpalfapvVGPVLGGFITTYLSWHWnffiniPLGAVGLALVARFIPgdreadpkplDWpgffltsag 216
Cdd:cd17317 107 ---------------------VGPKYRSFVGILFGLFW------ALGYMLLALLAYLIR----------DW--------- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 217 lalllygleRIAHpedgvLPTALLIVAGIVLGWLAVRHLrraphplldLSSFkVLTFAISTLAAGTIFRVAINATPFLLP 296
Cdd:cd17317 141 ---------RWLQ-----LAISLPGLLFLLLLWWLPRRT---------IIVG-LIWFVTSLVYYGLSLNSSNLGGNLYLN 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 297 LLFqvgfglspvdAGLM-ILAYFLGNLgmktvttpTLRRFGFRSVMVVNGIIASASIMACGAISPQTPqALVVALMLIAG 375
Cdd:cd17317 197 FFL----------SGLVeIPAYFLALL--------LLDRLGRRWTLSGSLLLAGLACLVTALLPDDEN-TLALTLALVGK 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 376 LSRSMQFTALNTLAFADIDASQRSSAATLSSMLQQVAMLfgvaVAAAILNLSQIVRdrpaldlvdfRVAFLAIGAIGLVA 455
Cdd:cd17317 258 FAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAI----LAPFIVLLGKIGP----------LLPLIIFGVLALLG 323
|
....*...
gi 1017221224 456 ALRFLVLP 463
Cdd:cd17317 324 GLLTLLLP 331
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
28-169 |
4.82e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.84 E-value: 4.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 28 FFMQLLDSTIISTSLPQMG----ASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGL 103
Cdd:cd17329 5 LIGSFLNRLGFFMVWPFMAiylhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGF 84
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1017221224 104 SQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTY 169
Cdd:cd17329 85 AHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY 150
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
8-120 |
6.07e-07 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 51.50 E-value: 6.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 8 ATLSETATHARRVALIVAIAFFMQL---LDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGAR 84
Cdd:PRK11551 1 MSTRTSSASSSRLALTIGLCFLVALlegLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRK 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 1017221224 85 NIFLLAIVLFTLASLACGLSQTLTQFVAARVVQGLG 120
Cdd:PRK11551 81 RILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVG 116
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
19-166 |
1.03e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 51.06 E-value: 1.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 19 RVALIVAIAFFMQLLDSTIISTSLPQMGAS-FGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLA 97
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1017221224 98 SLACGLSQ--TLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLN-------ATALITWPALFAPVVGPVLGGFI 166
Cdd:COG2211 308 LLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrreglYFGIFTFAIKLGQALAGALAGLL 385
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
18-191 |
3.03e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 49.08 E-value: 3.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 18 RRVALIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLA 97
Cdd:cd17324 198 PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAAL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 98 SLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLnATALITWPALFAPVVGPVLGGFITTYLSWHWNFF 177
Cdd:cd17324 278 LLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGL-ASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGW 356
|
170
....*....|....
gi 1017221224 178 INIPLGAVGLALVA 191
Cdd:cd17324 357 VGAALLLLALLLAL 370
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
47-190 |
4.20e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 48.81 E-value: 4.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 47 ASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGLSQTLTQFVAAR-VVQGLGSALMT 125
Cdd:cd17355 31 AEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWgLLGGGGAGTLA 110
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1017221224 126 PVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFInipLGAVGLALV 190
Cdd:cd17355 111 AVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLV---LALLALLVL 172
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
18-189 |
4.35e-06 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 48.73 E-value: 4.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 18 RRVALIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVY-MLTMAVFVPLSGWLADRFGARNIFLLAIVLFTL 96
Cdd:cd17330 174 PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVgIAGILAQLLLIPRLAKRLGERKLLRLGLLLAII 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 97 ASLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNF 176
Cdd:cd17330 254 GLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPF 333
|
170
....*....|...
gi 1017221224 177 FINIPLGAVGLAL 189
Cdd:cd17330 334 LLAAGLLLIALFL 346
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
42-195 |
4.99e-06 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 48.55 E-value: 4.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 42 LPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGLSQTLTQFVAARVVQGLGS 121
Cdd:PRK10091 26 LTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSYLMLAIGRLVSGFPH 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1017221224 122 ALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINIPLGAVGLALVARFIP 195
Cdd:PRK10091 106 GAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIAVFNIAVLASIYFWVP 179
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
18-193 |
1.04e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 47.54 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 18 RRVALIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLA 97
Cdd:COG0738 210 PRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVG 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 98 SLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWpALFAPVVGPVLGGFITTYLSWHWNFF 177
Cdd:COG0738 290 LLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIM-GIVGGAIGPPLIGFLADAFGLRAAFL 368
|
170
....*....|....*.
gi 1017221224 178 INIPLGAVGLALVARF 193
Cdd:COG0738 369 VPLVCYLLILLLALAL 384
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
47-457 |
1.17e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 47.60 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 47 ASFGVSPVAMSIGITVYMLT-MAVFVPLsGWLADRFGARNIFLLAIVLFT-LASLACGLSQTLTQFVAARVVQGLGSAlM 124
Cdd:cd17490 24 ESLGASLSMIGIILGAYGISqMLLRIPL-GILSDRIGKRKLFIIIGLLFTvLASLIMILFPSPWGLLIARFLSGIAAA-T 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 125 TPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINIPLGAVGLALVARFIPGDREADPKP 204
Cdd:cd17490 102 WVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 205 LDWPGFFltsaglalllygleriahpedGVLPTALLIVAGIvlgwLAVrhlrraphpLLDLSSFKVlTFAISTLAAGTIF 284
Cdd:cd17490 182 TELKELL---------------------SVLKDKKLLFFSL----LAI---------LQQMITFST-TFGFTPLIAKQLG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 285 rvainATPFLLPLLfqvgfglspvdAGLMILAYFLGNLGmktVTTPTLRRFGFRSVMVVNGIIASAsimACGAIsPQTPQ 364
Cdd:cd17490 227 -----ASSFQLGLL-----------SIIYLLPNALASLL---SGTLFYKKLGERNTIIIGFLLLGA---YCFLI-PFAPN 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 365 -ALVVALMLIAGLSRSMQFTALNTLAFADIDASQRSSAATLSSMLQQVAMLFGVAVAAAILNLSQIVrdrpaldlvdfrV 443
Cdd:cd17490 284 lTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQ------------T 351
|
410
....*....|....
gi 1017221224 444 AFLAIGAIGLVAAL 457
Cdd:cd17490 352 GFFVIGVIALLAAI 365
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
18-194 |
1.86e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 46.83 E-value: 1.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 18 RRVALIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLA-DRFGARNIFLLAIVLFTL 96
Cdd:cd17490 194 KKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFyKKLGERNTIIIGFLLLGA 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 97 ASLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSelLNATALITWPALFAP--VVGPVLGGFITTYLSWHW 174
Cdd:cd17490 274 YCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAE--QRSTAMGFFQAIYALgmFLGPVLVGIISEAFGLQT 351
|
170 180
....*....|....*....|
gi 1017221224 175 NFFINIPLGAVGLALVARFI 194
Cdd:cd17490 352 GFFVIGVIALLAAILSLAYY 371
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
39-194 |
2.15e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 46.60 E-value: 2.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 39 STSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGLSQTLTQFVAARVVQG 118
Cdd:TIGR00881 15 ALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNG 94
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1017221224 119 LGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGF-ITTYLSWHWNFFiniplGAVGLALVARFI 194
Cdd:TIGR00881 95 IFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFI-----VPGIIAIIVSLI 166
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
5-191 |
2.20e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 46.41 E-value: 2.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 5 PEIATLSETATHARRVALIVAIAFFMQLLDSTIIsTSLPQ-MGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGA 83
Cdd:cd17473 184 ASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIP-IQLPFlLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGK 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 84 RNIFLLAIVLFTLASLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLG 163
Cdd:cd17473 263 RRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVL 342
|
170 180
....*....|....*....|....*...
gi 1017221224 164 GFITTYLSWHWNFFINIPLGAVGLALVA 191
Cdd:cd17473 343 GPLVNLTGGLSGAFLILGVLALVLAIVL 370
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
1-122 |
2.50e-05 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 46.61 E-value: 2.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 1 MTAIPEIATLSETATHARRVALIVA-IAFFMQLLDSTIISTSLPQMGASFGVSPVAMSigitvyMLTMAVFVP------L 73
Cdd:PRK03893 1 MSTTTQNIPWYRHLNRAQWKAFSAAwLGYLLDGFDFVLITLVLTEVQGEFGLTTVQAA------SLISAAFISrwfgglL 74
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1017221224 74 SGWLADRFGARNIFLLAIVLFTLASLACGLSQTLTQFVAARVVQGLGSA 122
Cdd:PRK03893 75 LGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMA 123
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
22-196 |
3.10e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 46.01 E-value: 3.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 22 LIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITV----YMLTMAvfvpLSGWLADRFGARNIFLLAIVLFTLA 97
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSffwgYALTQV----LGGYLADRFGGKKVLLLAVALWSLA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 98 SLACGL--SQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWN 175
Cdd:cd17380 78 TLLTPLlaYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSV 157
|
170 180
....*....|....*....|.
gi 1017221224 176 FFINIPLGAVGLALVARFIPG 196
Cdd:cd17380 158 FYFFGLLGLLWALVWLIYLPP 178
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
63-188 |
3.24e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 46.07 E-value: 3.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 63 YMLTMAVfvplSGWLADRFGARNIFLLAI---VLFTLAS-LACGLSQTLtqFVAARVVQGLGSALMTPVGRILVLRNAPK 138
Cdd:cd17318 69 YILTQIP----GGYLAEKYGAKRVLGYSIlitALLTLLTpLAARGGYGA--LIVLRILQGLAQGVTFPAMHALWAKWAPP 142
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1017221224 139 SELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFInipLGAVGLA 188
Cdd:cd17318 143 LERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYI---FGGLGLL 189
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
20-194 |
3.58e-05 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 46.18 E-value: 3.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 20 VALIVAIAFFMQLLDSTIISTSLPQMGASFGVSPV------AMSIGITVYMLTMAVFVP--LSGWLADRFGARNIFLLAI 91
Cdd:TIGR00879 29 LSLIAAIGGLMFGYDTGVIGGALALPAFEFKFTSAnsdsysSSLWGLVVSIFLVGGFIGalFAGWLSDRFGRKKSLLIIA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 92 VLFTLASLACGLSQTLT---QFVAARVVQGLGSALMTPVGRILVLRNAPKSEllnATALITWPALFAPVVGPVLGGFITT 168
Cdd:TIGR00879 109 LLFVIGAILMGLAAFALsveMLIVGRVLLGIGVGIASALVPMYLSEIAPKAL---RGALTSLYQLAITFGILVAYGFGSG 185
|
170 180
....*....|....*....|....*.
gi 1017221224 169 YLSWHWNFFINIPLGAVGLALVARFI 194
Cdd:TIGR00879 186 KVSLNNTLGWRIPLGLQLIPAGLLFL 211
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
38-194 |
3.69e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 45.73 E-value: 3.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 38 ISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGLSQTLTQFVAARVVQ 117
Cdd:cd17312 22 FSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLN 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1017221224 118 GLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINIPLGAVGLALVARFI 194
Cdd:cd17312 102 GLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFL 178
|
|
| PRK06814 |
PRK06814 |
acyl-[ACP]--phospholipid O-acyltransferase; |
56-202 |
4.41e-05 |
|
acyl-[ACP]--phospholipid O-acyltransferase;
Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 46.11 E-value: 4.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 56 MSIGITVYMLTMAVFVPLSGWLADRFG----ARNIFLLAIVLFTLASLACGLSQTLTQFVAArVVQGLGSALMTPVGRIL 131
Cdd:PRK06814 54 VTLAGAVFILPFFIFSALAGQLADKYDkaklAKILKFAEIGIAALAIYGFHLNSVPLLFAAL-FLMGIHSALFGPIKYSI 132
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1017221224 132 VLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINIPLGAVGLaLVARFIPGDREADP 202
Cdd:PRK06814 133 LPDHLNKDELLGANALVEAGTFIAILLGTIIGGLATISGNFVILVALLMGIAVLGW-LASLFIPKTGNAAP 202
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
60-385 |
4.50e-05 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 45.78 E-value: 4.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 60 ITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKS 139
Cdd:TIGR00898 133 QSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKK 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 140 ELLNATALITWPALFAPVVGPVLGGFITtylSWHW-NFFINIPLGAVGLALVarFIPgdreadpkplDWPGFFLTSAGLA 218
Cdd:TIGR00898 213 QRAIVGTLIQVFFSLGLVLLPLVAYFIP---DWRWlQLAVSLPTFLFFLLSW--FVP----------ESPRWLISQGRIE 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 219 LLLYGLERIAHPEDGVLPTALLIVAgivlgwlAVRHLR--RAPHPLLDL---SSFKVLTFAISTLAAGTIFRVainatpF 293
Cdd:TIGR00898 278 EALKILQRIAKINGKKLPAEVLSLS-------LEKDLSssKKQYSFLDLfrtPNLRKTTLCLMMLWFTTAFSY------Y 344
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 294 LLPLLFQVGFGLSPVDAGLMILAYFLGNLgmktVTTPTLRRFGFRSVMVVNGIIASASIMACGAIsPQTPQALVVALMLI 373
Cdd:TIGR00898 345 GLVLDLGNLGGNIYLDLFISGLVELPAKL----ITLLLIDRLGRRYTMAASLLLAGVALLLLLFV-PVDLYFLRTALAVL 419
|
330
....*....|..
gi 1017221224 374 AGLSRSMQFTAL 385
Cdd:TIGR00898 420 GKFGITSAFQMV 431
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
10-124 |
4.82e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 45.60 E-value: 4.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 10 LSETATHARRVALIVAIAFFMQLLDSTIIST-SLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFL 88
Cdd:cd17369 219 LVEVLRRHWRALLLAIGLRLAENVLFYLFTTfALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYL 298
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1017221224 89 LAIVLFTLAS----LACGLSQTLTQFVAARVVQGLGSALM 124
Cdd:cd17369 299 AGALLAALFAfpffWLLDTGSTWLIVLAAVVVLGVLHGMM 338
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
25-120 |
5.06e-05 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 45.34 E-value: 5.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 25 AIAFFMQLLDSTIISTSLPQMGASFGVSP---------VAMSIGitvymlTMAVFVPLSGWLADRFGARNIFLLAIVLFT 95
Cdd:cd17360 3 GIGGFLFGYDTGVISGALLYIKDDLGEVVlstgwqeliVSSTVA------GAAVGAAIGGWLNDRFGRRPCILLADALFT 76
|
90 100
....*....|....*....|....*
gi 1017221224 96 LASLACGLSQTLTQFVAARVVQGLG 120
Cdd:cd17360 77 IGAIVMAAAPNKEVLIVGRVLVGLG 101
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-189 |
5.46e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.50 E-value: 5.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 18 RRVALIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADR-FGARNIFLLAIVLFTL 96
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 97 ASLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALI-TWPALFAPVVGPVLGGFITTYLSWHWN 175
Cdd:cd06174 283 GLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLnTFGFLGGAIGPLLAGFLLAATFGLTGA 362
|
170
....*....|....
gi 1017221224 176 FFINIPLGAVGLAL 189
Cdd:cd06174 363 FLVLAVLLLLAAIL 376
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
73-139 |
5.73e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 45.26 E-value: 5.73e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1017221224 73 LSGWLADRFGARNIFLLAIVLFTLASLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKS 139
Cdd:cd17315 53 FGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAK 119
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
47-190 |
2.03e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 43.69 E-value: 2.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 47 ASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGLSQTLTQFVAARVVQGLGSALMTP 126
Cdd:cd17370 227 QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQES 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1017221224 127 VGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFFINIPLGAVGLALV 190
Cdd:cd17370 307 IERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
20-195 |
2.24e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 43.41 E-value: 2.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 20 VALIVAIAFFMQLLDSTIISTSLPQMGAS--FGVSP---------VAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFL 88
Cdd:pfam00083 1 VALVAALGGFLFGYDTGVIGAFLTLIDFFknFGLSKsvsslaalsVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 89 LAIVLFTLASLACGLS---QTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSellNATALITWPALFapVVGPVLGGF 165
Cdd:pfam00083 81 IANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKK---LRGALGSLYQLA--ITFGILLAY 155
|
170 180 190
....*....|....*....|....*....|....*...
gi 1017221224 166 ITTYLS--------WHWNFFINIPLgAVGLALVARFIP 195
Cdd:pfam00083 156 IFGLGLnktsnsdgWRIPLGLQLVP-ALLLIIGLLFLP 192
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
18-160 |
3.06e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.79 E-value: 3.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 18 RRVALIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLA 97
Cdd:pfam07690 199 RDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA 278
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1017221224 98 SLACGLSQTLTQ---FVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGP 160
Cdd:pfam07690 279 ALGLLLLSLTLSslwLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
23-214 |
3.29e-04 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 43.12 E-value: 3.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 23 IVAIAFFMQlldstIISTSLPQMGASFGVSPvAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACG 102
Cdd:pfam06609 53 VCATYFVLQ-----ASASALPNILQDIGQSE-NQGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGC 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 103 LSQTLTQFVAARVVQGL--GSALMTP--VGRILvlrnAPKSELLnATALITWPALFAPVVGPVLGGFITTYLSWHWNFFI 178
Cdd:pfam06609 127 TANKFNTLLAAMTLLGVaaGPAGASPlfIGELM----SNKTKFL-GLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYI 201
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1017221224 179 NIPLGAVGLALVA--RFIPGDREADPK---------PLDWPGFFLTS 214
Cdd:pfam06609 202 YIIMSAIAVLLIIiwYHPPSFAQLHGKkarkrdelaKLDWIGIFLVI 248
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
42-203 |
3.49e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.93 E-value: 3.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 42 LPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGLSQTLTQFVAARVVQGLGS 121
Cdd:cd17478 19 LPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 122 ALMTPVGRILVLRNAPKSELLNATALITWPAL-FApvVGPVLGGFITTYLSWHWNFFINIPLGAVGLALVARFIPGDREA 200
Cdd:cd17478 99 AAFHPEGARLASQAAGGRRGLAMSIFSVGGNLgFA--LGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPE 176
|
...
gi 1017221224 201 DPK 203
Cdd:cd17478 177 AKK 179
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
49-457 |
4.63e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.58 E-value: 4.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 49 FGVSPVAMSIGITVYMLTMAVFVPLSGWLAD----RFGARNIFLL-AIVLFTLASLACGLSQTLTQ------FVAARVVQ 117
Cdd:COG2211 41 LGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWILiGAIPLALSFVLLFTAPDLSPtgkliyALVTYLLL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 118 GLG-SALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLS------WHWNFFINIPLGAVGLALV 190
Cdd:COG2211 121 GLAyTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaalgYRLTALIFAVLGLLAFLLT 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 191 ARFIPGDREADPKPLDWPGFFLTSAGLalllygleriahpedgvlPTALLIVAGIVLGWLAVrhlrraphplldlssfkv 270
Cdd:COG2211 201 FFGTKERPVPEEEKVSLKESLKALLKN------------------RPFLLLLLAYLLFFLAL------------------ 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 271 ltfaistlaagtifrvaiNATPFLLPLLFQVGFGLSPVDAGLMILAYFLGNLGMKTVTTPTLRRFGFRSVMVVNGIIASA 350
Cdd:COG2211 245 ------------------ALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 351 SIMACGAISPQTPqALVVALMLIAGLSRSMQFTALNTLaFADI--------DASQRSSAATLSSMLQQVAMLFGVAVAAA 422
Cdd:COG2211 307 GLLLLFFLGPGNL-WLLLVLAALAGIGLGAILVLPWAM-LADVvdydewktGRRREGLYFGIFTFAIKLGQALAGALAGL 384
|
410 420 430
....*....|....*....|....*....|....*..
gi 1017221224 423 ILNLSQIV--RDRPALDLVDFRVAFLAIGAIGLVAAL 457
Cdd:COG2211 385 LLALFGYVagAAQSPSALTGIRLLFFLLPAVLLLLAA 421
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
18-191 |
5.63e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.16 E-value: 5.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 18 RRVALIVAIAFFMQLLDSTIIStSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLA 97
Cdd:cd17477 188 RIAPLALLGAFVAGFLEGAFYS-LLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALA 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 98 SLACGL-SQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWnF 176
Cdd:cd17477 267 ALLLPLvPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHG-L 345
|
170
....*....|....*
gi 1017221224 177 FINIPLGAVGLALVA 191
Cdd:cd17477 346 FLFLAAVALLFLLFL 360
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
18-193 |
6.11e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.21 E-value: 6.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 18 RRVALIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAM-SIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTL 96
Cdd:cd17329 199 DRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLlGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAI 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 97 ASLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNF 176
Cdd:cd17329 279 GFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPW 358
|
170
....*....|....*..
gi 1017221224 177 FINIPLGAVGLALVARF 193
Cdd:cd17329 359 LILAALGLIAAALLLGL 375
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
68-178 |
6.60e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 41.87 E-value: 6.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 68 AVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATAL 147
Cdd:cd17391 254 LLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGY 333
|
90 100 110
....*....|....*....|....*....|.
gi 1017221224 148 ITWPALFAPVVGPVLGGFITTYLSWHWNFFI 178
Cdd:cd17391 334 NQSFQYLGNVAGPLLGSAIAAHFGYRAVFVV 364
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
29-169 |
7.83e-04 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 41.44 E-value: 7.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 29 FMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGLSQTLT 108
Cdd:cd17390 6 FLDLFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLA 85
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1017221224 109 QFVAARVVQGLGSALMTpVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTY 169
Cdd:cd17390 86 LLFLSRIPLGIFKHTQS-LCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAET 145
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
22-426 |
1.25e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.00 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 22 LIVAIAFFMqlLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLAC 101
Cdd:cd17477 1 LLLSVALLG--LGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 102 GLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYlswhwnffinip 181
Cdd:cd17477 79 ALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA------------ 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 182 lgavglalvarfipgdreadpkplDWPGFFLTSaglalllygleriahpedgvlptALLIVAGIVLgwLAVRHLRRAPHP 261
Cdd:cd17477 147 ------------------------GALPFLIAA-----------------------VLLLLALVPL--LLTRRAAPEIEE 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 262 LLDLSSFKVLTFAISTLAAGTIFRVAINATPFLLPlLFQVGFGLSPVDAGLMILAYFLGNLGMKTVTTPTLRRFGFRSVM 341
Cdd:cd17477 178 AESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLP-LYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVL 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 342 VVNGIIASASIMAcGAISPQTPQALVVALMLIAGLSRSMQFTALnTLAFADIDASQRSSAATLSSMLQQVAMLFGVAVAA 421
Cdd:cd17477 257 LGCALLGALAALL-LPLVPGLPLALLVLLFLWGGAAGPLYTLAL-ALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAG 334
|
....*
gi 1017221224 422 AILNL 426
Cdd:cd17477 335 ALMDA 339
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
38-202 |
2.39e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 40.25 E-value: 2.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 38 ISTSLPQMGAS-FGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGLSQ-TLTQFVAARV 115
Cdd:COG2223 224 FSSWLPPYLVDqFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFL 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 116 VQGLGSALMTPVGRILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFI-TTYLSWHWNFFINIPLGAVGLALVARFI 194
Cdd:COG2223 304 LLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALlDATGSYTAAFLVFAVLALVALVLTLLLY 383
|
....*...
gi 1017221224 195 PGDREADP 202
Cdd:COG2223 384 RRPRRAAA 391
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
24-193 |
2.80e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 40.00 E-value: 2.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 24 VAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLACGL 103
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 104 SQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSEllnATALITWPALF--APVVGPVLGG-FITTYLSWHWNFFIni 180
Cdd:cd17333 81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESS---ATRLNVLHGFFglGALIGPLIATsLLTSELSWSWAYLI-- 155
|
170
....*....|...
gi 1017221224 181 pLGAVGLALVARF 193
Cdd:cd17333 156 -IGLIYLLLAILI 167
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
18-194 |
3.11e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 39.93 E-value: 3.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 18 RRVALIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLA 97
Cdd:cd17393 199 RLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALG 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 98 SLACGLSQTLTQFVAARVVQGLGSALMTPVGrILVLRNAPKSELLNATALITWPALFAPVVGPVLGGFITTYLSWHWNFF 177
Cdd:cd17393 279 LLLALLAPSVWVALAGFALMGLGLSVVVPLA-FSAAGALPGLAAGIAVARVATLGYLGFLVGPPLIGFLADATGLRTAFL 357
|
170
....*....|....*..
gi 1017221224 178 InIPLGAVGLALVARFI 194
Cdd:cd17393 358 V-VALLALLVALLARAV 373
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
19-197 |
3.18e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 39.92 E-value: 3.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 19 RVALIVAIAFFMQLLDSTIISTSLPQ-MGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLA 97
Cdd:cd17327 5 FILPLLCILYFLQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 98 SLACGLSQTLTQFVAARVVQGLGSALMTPVGRILVLRNAPKSELlnaTALITWPALFAPvVGPVLGGFITTYL------- 170
Cdd:cd17327 85 TLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQ---AKRIAFFYAAAG-LGSIFGGLLAYGVfkilgvg 160
|
170 180 190
....*....|....*....|....*....|
gi 1017221224 171 ---SWHWNFFINIPLGAVGLALVARFIPGD 197
Cdd:cd17327 161 glaGWRWLFIIEGLITIIIGLVIFFWLPDN 190
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
278-483 |
4.20e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.19 E-value: 4.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 278 LAAGTIFRVAINATPFLLPLLFQvGFGLSPVDAGLMILAYFLGNLGMKTVTTPTLRRFGFRSVMVVNGIIASASIMACGA 357
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 358 IspqTPQALVVALMLIAGLSRSMQFTALNTLAFADIDASQRSSAATLSSMLQQVAMLFGVAVAAAIlnlsqivrdrpaLD 437
Cdd:COG2814 95 A---PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL------------AD 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1017221224 438 LVDFRVAFLAIGAIGLVAALRFLVLPPGAGAEVSGHSPGNSDRFFR 483
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLR 205
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
23-126 |
5.54e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.07 E-value: 5.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 23 IVAIAFFMQLLDSTIISTS----LPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLAS 98
Cdd:cd17352 3 VVVFASFLVNFFTDGILNSfgvlFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGL 82
|
90 100
....*....|....*....|....*....
gi 1017221224 99 LACGLSQTLTQF-VAARVVQGLGSALMTP 126
Cdd:cd17352 83 LLSSFATSLWQLyLTYGVLGGLGLGLIYS 111
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
22-124 |
8.22e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 38.39 E-value: 8.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017221224 22 LIVAIAFFMQLLDSTIISTSLPQMGASFGVSPVAMSIGITVYMLTMAVFVPLSGWLADRFGARNIFLLAIVLFTLASLAC 101
Cdd:cd17393 2 LAVAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLL 81
|
90 100
....*....|....*....|...
gi 1017221224 102 GLSQTLTQFVAARVVQGLGSALM 124
Cdd:cd17393 82 GLAPSVPALALALFLFGAANGAL 104
|
|
| |
