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ISC system 2Fe-2S type ferredoxin [Aeromonas salmonicida]

Protein Classification

ISC system 2Fe-2S type ferredoxin( domain architecture ID 10797691)

ISC system 2Fe-2S type ferredoxin is an iron-sulfur protein that transfers electrons in a wide variety of metabolic reactions, and is associated with and essential to the ISC system

CATH:  3.10.20.30
Gene Ontology:  GO:0016226|GO:0051536|GO:0046872|GO:0009055
SCOP:  3000113

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
fdx_isc TIGR02007
ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins ...
 2-110 1.89e-60

ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins associated with and essential to the ISC system of 2Fe-2S cluster assembly. This family is closely related to (but excludes) eukaryotic (mitochondrial) adrenodoxins, which are ferredoxins involved in electron transfer to P450 cytochromes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


:

Pssm-ID: 131062 [Multi-domain]  Cd Length: 110  Bit Score: 180.37  E-value: 1.89e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028228754   2 PKLIILPHPELCPDGAALEGKSGESILDVALRNGIEIEHACEKSCACTTCHCVVREGFDSLEPSDELEDDMLDKAWGLEP 81
Cdd:TIGR02007   1 PKIVFLPHEDLCPEGAVVEAKPGETILDVALDNGIEIEHACEKSCACTTCHCIVREGFDSLEEASEQEEDMLDKAWGLEP 80

                          90       100
                  ....*....|....*....|....*....
gi 1028228754  82 ESRLSCQARLADEDLVVELPKYTINLASE 110
Cdd:TIGR02007  81 DSRLSCQAVVADEDLVVEIPKYTINHARE 109
 
Name Accession Description Interval E-value
fdx_isc TIGR02007
ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins ...
 2-110 1.89e-60

ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins associated with and essential to the ISC system of 2Fe-2S cluster assembly. This family is closely related to (but excludes) eukaryotic (mitochondrial) adrenodoxins, which are ferredoxins involved in electron transfer to P450 cytochromes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 131062 [Multi-domain]  Cd Length: 110  Bit Score: 180.37  E-value: 1.89e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028228754   2 PKLIILPHPELCPDGAALEGKSGESILDVALRNGIEIEHACEKSCACTTCHCVVREGFDSLEPSDELEDDMLDKAWGLEP 81
Cdd:TIGR02007   1 PKIVFLPHEDLCPEGAVVEAKPGETILDVALDNGIEIEHACEKSCACTTCHCIVREGFDSLEEASEQEEDMLDKAWGLEP 80

                          90       100
                  ....*....|....*....|....*....
gi 1028228754  82 ESRLSCQARLADEDLVVELPKYTINLASE 110
Cdd:TIGR02007  81 DSRLSCQAVVADEDLVVEIPKYTINHARE 109
PLN02593 PLN02593
adrenodoxin-like ferredoxin protein
 14-112 3.41e-24

adrenodoxin-like ferredoxin protein


Pssm-ID: 178203 [Multi-domain]  Cd Length: 117  Bit Score: 89.01  E-value: 3.41e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028228754  14 PDGA--ALEGKSGESILDVALRNGIEIEHACEKSCACTTCHCVV--REGFDSLEPSDELEDDMLDKAWGLEPESRLSCQ- 88
Cdd:PLN02593    8 KDGEerTVKAPVGMSLLEAAHENDIELEGACEGSLACSTCHVIVmdEKVYNKLPEPTDEENDMLDLAFGLTETSRLGCQv 87

                          90       100
                  ....*....|....*....|....*
gi 1028228754  89 -ARLADEDLVVELPKYTINLASERH 112
Cdd:PLN02593   88 iAKPELDGMRLALPAATRNFAVDGH 112
Fdx COG0633
Ferredoxin [Energy production and conversion];
1-101 1.75e-23

Ferredoxin [Energy production and conversion];


Pssm-ID: 440398 [Multi-domain]  Cd Length: 87  Bit Score: 86.06  E-value: 1.75e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028228754   1 MPKLIILPHpelcpdGAALEGKSGESILDVALRNGIEIEHACEkSCACTTCHCVVREGFdslepSDELEDDMLDkAWGLE 80
Cdd:COG0633     1 MPKVTFIPE------GHTVEVPAGESLLEAALRAGIDLPYSCR-SGACGTCHVRVLEGE-----VDHREEDALS-DEERA 67

                          90       100
                  ....*....|....*....|.
gi 1028228754  81 PESRLSCQARLADeDLVVELP 101
Cdd:COG0633    68 AGSRLACQARPTS-DLVVELP 87
fer2 cd00207
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in ...
 14-99 9.95e-15

2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.


Pssm-ID: 238126 [Multi-domain]  Cd Length: 84  Bit Score: 63.57  E-value: 9.95e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028228754  14 PDGAALEGKSGESILDVALRNGIEIEHACEKScACTTCHCVVREGfdslepSDELEDDMLDKAWGLEPESRLSCQARLAD 93
Cdd:cd00207     7 GSGVEVEVPEGETLLDAAREAGIDIPYSCRAG-ACGTCKVEVVEG------EVDQSDPSLLDEEEAEGGYVLACQTRVTD 79


                  ....*.
gi 1028228754  94 eDLVVE 99
Cdd:cd00207    80 -GLVIE 84
Fer2 pfam00111
2Fe-2S iron-sulfur cluster binding domain;
11-91 2.47e-09

2Fe-2S iron-sulfur cluster binding domain;


Pssm-ID: 395061 [Multi-domain]  Cd Length: 77  Bit Score: 49.83  E-value: 2.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028228754  11 ELCPDGAALEGKSGES-ILDVALRNGIEIEHACEKSCaCTTCHCVVREGFDSLEPSdELEDDMLDKAWGLepesrLSCQA 89
Cdd:pfam00111   2 TINGKGVTIEVPDGETtLLDAAEEAGIDIPYSCRGGG-CGTCAVKVLEGEDQSDQS-FLEDDELAAGYVV-----LACQT 74


                  ..
gi 1028228754  90 RL 91
Cdd:pfam00111  75 YP 76
 
Name Accession Description Interval E-value
fdx_isc TIGR02007
ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins ...
 2-110 1.89e-60

ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins associated with and essential to the ISC system of 2Fe-2S cluster assembly. This family is closely related to (but excludes) eukaryotic (mitochondrial) adrenodoxins, which are ferredoxins involved in electron transfer to P450 cytochromes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 131062 [Multi-domain]  Cd Length: 110  Bit Score: 180.37  E-value: 1.89e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028228754   2 PKLIILPHPELCPDGAALEGKSGESILDVALRNGIEIEHACEKSCACTTCHCVVREGFDSLEPSDELEDDMLDKAWGLEP 81
Cdd:TIGR02007   1 PKIVFLPHEDLCPEGAVVEAKPGETILDVALDNGIEIEHACEKSCACTTCHCIVREGFDSLEEASEQEEDMLDKAWGLEP 80

                          90       100
                  ....*....|....*....|....*....
gi 1028228754  82 ESRLSCQARLADEDLVVELPKYTINLASE 110
Cdd:TIGR02007  81 DSRLSCQAVVADEDLVVEIPKYTINHARE 109
PLN02593 PLN02593
adrenodoxin-like ferredoxin protein
 14-112 3.41e-24

adrenodoxin-like ferredoxin protein


Pssm-ID: 178203 [Multi-domain]  Cd Length: 117  Bit Score: 89.01  E-value: 3.41e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028228754  14 PDGA--ALEGKSGESILDVALRNGIEIEHACEKSCACTTCHCVV--REGFDSLEPSDELEDDMLDKAWGLEPESRLSCQ- 88
Cdd:PLN02593    8 KDGEerTVKAPVGMSLLEAAHENDIELEGACEGSLACSTCHVIVmdEKVYNKLPEPTDEENDMLDLAFGLTETSRLGCQv 87

                          90       100
                  ....*....|....*....|....*
gi 1028228754  89 -ARLADEDLVVELPKYTINLASERH 112
Cdd:PLN02593   88 iAKPELDGMRLALPAATRNFAVDGH 112
Fdx COG0633
Ferredoxin [Energy production and conversion];
1-101 1.75e-23

Ferredoxin [Energy production and conversion];


Pssm-ID: 440398 [Multi-domain]  Cd Length: 87  Bit Score: 86.06  E-value: 1.75e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028228754   1 MPKLIILPHpelcpdGAALEGKSGESILDVALRNGIEIEHACEkSCACTTCHCVVREGFdslepSDELEDDMLDkAWGLE 80
Cdd:COG0633     1 MPKVTFIPE------GHTVEVPAGESLLEAALRAGIDLPYSCR-SGACGTCHVRVLEGE-----VDHREEDALS-DEERA 67

                          90       100
                  ....*....|....*....|.
gi 1028228754  81 PESRLSCQARLADeDLVVELP 101
Cdd:COG0633    68 AGSRLACQARPTS-DLVVELP 87
fer2 cd00207
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in ...
 14-99 9.95e-15

2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.


Pssm-ID: 238126 [Multi-domain]  Cd Length: 84  Bit Score: 63.57  E-value: 9.95e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028228754  14 PDGAALEGKSGESILDVALRNGIEIEHACEKScACTTCHCVVREGfdslepSDELEDDMLDKAWGLEPESRLSCQARLAD 93
Cdd:cd00207     7 GSGVEVEVPEGETLLDAAREAGIDIPYSCRAG-ACGTCKVEVVEG------EVDQSDPSLLDEEEAEGGYVLACQTRVTD 79


                  ....*.
gi 1028228754  94 eDLVVE 99
Cdd:cd00207    80 -GLVIE 84
NqrF COG2871
Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and ...
 14-101 2.66e-14

Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF is part of the Pathway/BioSystem: Na+-translocating NADH dehydrogenase


Pssm-ID: 442118 [Multi-domain]  Cd Length: 396  Bit Score: 67.19  E-value: 2.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028228754  14 PDGAALEGKSGESILDVALRNGIEIEHACEKSCACTTCHCVVREGFDSLEPSDE--LEDDMLDKAWglepesRLSCQARL 91
Cdd:COG2871    41 GDGKEIEVEEGQTLLDALLRQGIFLPSACGGGGTCGQCKVKVLEGGGDILPTETfhLSDRERKEGY------RLACQVKV 114

                          90
                  ....*....|
gi 1028228754  92 aDEDLVVELP 101
Cdd:COG2871   115 -KSDMEIEVP 123
PTZ00490 PTZ00490
Ferredoxin superfamily; Provisional
 26-107 1.39e-10

Ferredoxin superfamily; Provisional


Pssm-ID: 185668  Cd Length: 143  Bit Score: 54.49  E-value: 1.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028228754  26 SILDVAlrnGIEIEHACEKSCACTTCHCVVREG-FDSLEPSDELEDDMLDKAWGLEPESRLSCQARLADE--DLVVELPK 102
Cdd:PTZ00490   61 ALRDVA---KLDVEGTCNGCMQCATCHVYLSAAsFKKLGGPSEEEEDVLAKALDVKETSRLACQVDLTPEmdGLEVELPS 137


                  ....*
gi 1028228754 103 YTINL 107
Cdd:PTZ00490  138 YVTNR 142
COG3894 COG3894
Uncharacterized 2Fe-2S and 4Fe-4S clusters-containing protein, contains DUF4445 domain ...
 14-101 2.09e-10

Uncharacterized 2Fe-2S and 4Fe-4S clusters-containing protein, contains DUF4445 domain [Function unknown];


Pssm-ID: 443101 [Multi-domain]  Cd Length: 621  Bit Score: 55.97  E-value: 2.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028228754  14 PDGAALEGKSGESILDVALRNGIEIEHACEKSCACTTCHCVVREGfdSLEPSDELEDDMLDKAwGLEPESRLSCQARLAd 93
Cdd:COG3894    10 PSGKRVEVEAGTTLLDAAREAGVDIDAPCGGRGTCGKCKVKVEEG--EFSPVTEEERRLLSPE-ELAEGYRLACQARVL- 85


                  ....*...
gi 1028228754  94 EDLVVELP 101
Cdd:COG3894    86 GDLVVEVP 93
Fer2 pfam00111
2Fe-2S iron-sulfur cluster binding domain;
11-91 2.47e-09

2Fe-2S iron-sulfur cluster binding domain;


Pssm-ID: 395061 [Multi-domain]  Cd Length: 77  Bit Score: 49.83  E-value: 2.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028228754  11 ELCPDGAALEGKSGES-ILDVALRNGIEIEHACEKSCaCTTCHCVVREGFDSLEPSdELEDDMLDKAWGLepesrLSCQA 89
Cdd:pfam00111   2 TINGKGVTIEVPDGETtLLDAAEEAGIDIPYSCRGGG-CGTCAVKVLEGEDQSDQS-FLEDDELAAGYVV-----LACQT 74


                  ..
gi 1028228754  90 RL 91
Cdd:pfam00111  75 YP 76
PRK07609 PRK07609
CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated
 14-104 7.46e-09

CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated


Pssm-ID: 181058 [Multi-domain]  Cd Length: 339  Bit Score: 51.41  E-value: 7.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028228754  14 PDGAALEGKSGESILDVALRNGIEIEHACeKSCACTTCHCVVREGfdslepsDELEDDMLDKAWGLEPESR---LSCQAR 90
Cdd:PRK07609    9 PSGRQFTAEPDETILDAALRQGIHLPYGC-KNGACGSCKGRLLEG-------EVEQGPHQASALSGEERAAgeaLTCCAK 80

                          90
                  ....*....|....
gi 1028228754  91 lADEDLVVELPKYT 104
Cdd:PRK07609   81 -PLSDLVLEAREVP 93
PRK05713 PRK05713
iron-sulfur-binding ferredoxin reductase;
10-100 2.15e-04

iron-sulfur-binding ferredoxin reductase;


Pssm-ID: 235575 [Multi-domain]  Cd Length: 312  Bit Score: 38.94  E-value: 2.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028228754  10 PELCPDGAALEGKSGESILDVALRNGIEIEHACEK-SCACTTCHCVVREGFDSLepSDELEDDMLDKAWglepesRLSCQ 88
Cdd:PRK05713    2 PELRVGERRWSVPAGSNLLDALNAAGVAVPYSCRAgSCHACLVRCLQGEPEDAL--PEALAAEKREQGW------RLACQ 73

                          90
                  ....*....|..
gi 1028228754  89 ARLaDEDLVVEL 100
Cdd:PRK05713   74 CRV-VGDLRVEV 84
PRK08493 PRK08493
NADH-quinone oxidoreductase subunit G;
15-53 6.26e-04

NADH-quinone oxidoreductase subunit G;


Pssm-ID: 236277 [Multi-domain]  Cd Length: 819  Bit Score: 37.76  E-value: 6.26e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1028228754  15 DGAALEGKSGESILDVALRNGIEIEHACEKSCACTTCHC 53
Cdd:PRK08493    7 NGKECEAQEGEYILNVARRNGIFIPAICYLSGCSPTLAC 45
antC PRK11872
anthranilate 1,2-dioxygenase electron transfer component AntC;
22-91 2.03e-03

anthranilate 1,2-dioxygenase electron transfer component AntC;


Pssm-ID: 183350 [Multi-domain]  Cd Length: 340  Bit Score: 35.87  E-value: 2.03e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1028228754  22 KSGESILDVALRNGIEIEHACEKScACTTCHCVVREGFDSLEPSDEledDMLDKAwGLEPESRLSCQARL 91
Cdd:PRK11872   20 GKDELLLDAALRNGINLPLDCREG-VCGTCQGRCESGIYSQDYVDE---DALSER-DLAQRKMLACQTRV 84
PTZ00038 PTZ00038
ferredoxin; Provisional
 14-79 2.48e-03

ferredoxin; Provisional


Pssm-ID: 240237 [Multi-domain]  Cd Length: 191  Bit Score: 35.58  E-value: 2.48e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1028228754  14 PDG-AALEGKSGESILDVALRNGIEIEHACeKSCACTTCHCVVREGfdSLEPSDE--LEDDMLDKAWGL 79
Cdd:PTZ00038  103 PDGeKVIECDEDEYILDAAERQGVELPYSC-RGGSCSTCAAKLLEG--EVDNEDQsyLDDEQLKKGYCL 168
petF CHL00134
ferredoxin; Validated
 27-79 5.72e-03

ferredoxin; Validated


Pssm-ID: 177056 [Multi-domain]  Cd Length: 99  Bit Score: 33.54  E-value: 5.72e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1028228754  27 ILDVALRNGIEIEHACeKSCACTTCHCVVREGfdSLEPSDE--LEDDMLDKAWGL 79
Cdd:CHL00134   27 ILDAAEEQGIDLPYSC-RAGACSTCAGKVTEG--TVDQSDQsfLDDDQLEAGFVL 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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