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Conserved domains on  [gi|1054590835|ref|WP_066359328|]
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TonB-system energizer ExbB [Aliarcobacter cryaerophilus]

Protein Classification

MotA/TolQ/ExbB proton channel family protein( domain architecture ID 669)

MotA/TolQ/ExbB proton channel family protein similar to flagellar motor protein MotA and biopolymer transporter ExbB/TolQ

Gene Ontology:  GO:0016020|GO:0015252
TCDB:  1.A.30

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10414 super family cl00568
biopolymer transporter ExbB;
5-140 4.73e-31

biopolymer transporter ExbB;


The actual alignment was detected with superfamily member TIGR02805:

Pssm-ID: 469824  Cd Length: 138  Bit Score: 108.33  E-value: 4.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1054590835   5 ETLKHLVDYGVIALLVIMSFIAVFFFIERVLFYKKIDVKSYKTKKALDIALTKHLTIIGTIASNSPYIGLLGTVLAIMLT 84
Cdd:TIGR02805   1 DFLKQYSDYFIFGILGLMSIIALAMVIERYLFLRKISVAHYSTIHQLDIDLNRNLTVISIIGSNAPYIGLLGTVIGIMVT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1054590835  85 FMTMGNAGDIDASKIMESLALALKATAAGLVVAIISMVFYNILSRFAEVLESDYEA 140
Cdd:TIGR02805  81 FYQMGHGGGIDPSVIMLGLSLALKATALGLLVAIPSLVFYNALLRKVEVNRLAWKV 136
 
Name Accession Description Interval E-value
exbB2 TIGR02805
tonB-system energizer ExbB, group 2; Members of this protein family appear to be the ExbB ...
 5-140 4.73e-31

tonB-system energizer ExbB, group 2; Members of this protein family appear to be the ExbB protein of an ExbBD proton-transporting membrane complex that, by means of TonB, energizes transport by TonB-dependent receptors. Note that this family represents one of at least two distinct groups TolQ homologs designated ExbB - see also TIGR02797. Each group associates with a distinct group of ExbD proteins, and a single species may have two ExbB/ExbD/TonB systems. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 131852  Cd Length: 138  Bit Score: 108.33  E-value: 4.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1054590835   5 ETLKHLVDYGVIALLVIMSFIAVFFFIERVLFYKKIDVKSYKTKKALDIALTKHLTIIGTIASNSPYIGLLGTVLAIMLT 84
Cdd:TIGR02805   1 DFLKQYSDYFIFGILGLMSIIALAMVIERYLFLRKISVAHYSTIHQLDIDLNRNLTVISIIGSNAPYIGLLGTVIGIMVT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1054590835  85 FMTMGNAGDIDASKIMESLALALKATAAGLVVAIISMVFYNILSRFAEVLESDYEA 140
Cdd:TIGR02805  81 FYQMGHGGGIDPSVIMLGLSLALKATALGLLVAIPSLVFYNALLRKVEVNRLAWKV 136
TolQ COG0811
Biopolymer transport protein ExbB/TolQ [Intracellular trafficking, secretion, and vesicular ...
 14-140 4.62e-15

Biopolymer transport protein ExbB/TolQ [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440573  Cd Length: 199  Bit Score: 68.33  E-value: 4.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1054590835  14 GVIALLVIMSFIAVFFFIERVLFYKKIDVKSYK----------------------------------------------- 46
Cdd:COG0811    11 LVMIPLLLLSVLSWAIIIERLLFLRRARRRARKflraflelwsagdldeaielcearnsplarilaaglrelksgggrea 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1054590835  47 TKKALDIA-------LTKHLTIIGTIASNSPYIGLLGTVLAIMLTFMTMGNAGDIDASKIMESLALALKATAAGLVVAII 119
Cdd:COG0811    91 IERALEEAasrelprLERGLSFLATIGSIAPLLGLLGTVWGMINAFQAIAAAGQADLAVVAGGISEALITTAAGLAVAIP 170

                         170       180
                  ....*....|....*....|.
gi 1054590835 120 SMVFYNILSRFAEVLESDYEA 140
Cdd:COG0811   171 AVIAYNYFSRRIDRLVAELEE 191
MotA_ExbB pfam01618
MotA/TolQ/ExbB proton channel family; This family groups together integral membrane proteins ...
 31-135 6.10e-14

MotA/TolQ/ExbB proton channel family; This family groups together integral membrane proteins that appear to be involved translocation of proteins across a membrane. These proteins are probably proton channels. MotA is an essential component of the flageller motor that uses a proton gradient to generate rotational motion in the flageller. ExbB is part of the TonB-dependent transduction complex. The TonB complex uses the proton gradient across the inner bacterial membrane to transport large molecules across the outer bacterial membrane.


Pssm-ID: 460268  Cd Length: 120  Bit Score: 63.65  E-value: 6.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1054590835  31 IERVLFYKKID-----VKSYKTKKALDIALT-------KHLTIIGTIASNSPYIGLLGTVLAIMLTFMTMGNAGdIDASK 98
Cdd:pfam01618   5 PEDRFLKKGLQlvvdgTDPEEIRRALEEAIDreeerleRGLSILATIGSLAPLLGLLGTVLGLIHAFQNLGDAG-PGLSA 83

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1054590835  99 IMESLALALKATAAGLVVAIISMVFYNILSRFAEVLE 135
Cdd:pfam01618  84 LAPGIAEALIATAYGLFVAIPALPFYNKLKRRSEREV 120
PRK10801 PRK10801
Tol-Pal system protein TolQ;
54-139 1.33e-06

Tol-Pal system protein TolQ;


Pssm-ID: 182743  Cd Length: 227  Bit Score: 46.01  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1054590835  54 ALTKHLTIIGTIASNSPYIGLLGTVLAIMLTFMTMGNAGDIDASKIMESLALALKATAAGLVVAIISMVFYNILSRFAEV 133
Cdd:PRK10801  119 TLETHIPFLGTVGSISPYIGLFGTVWGIMHAFIALGAVKQATLQMVAPGIAEALIATAIGLFAAIPAVMAYNRLNQRVNK 198


                  ....*.
gi 1054590835 134 LESDYE 139
Cdd:PRK10801  199 LELNYD 204
 
Name Accession Description Interval E-value
exbB2 TIGR02805
tonB-system energizer ExbB, group 2; Members of this protein family appear to be the ExbB ...
 5-140 4.73e-31

tonB-system energizer ExbB, group 2; Members of this protein family appear to be the ExbB protein of an ExbBD proton-transporting membrane complex that, by means of TonB, energizes transport by TonB-dependent receptors. Note that this family represents one of at least two distinct groups TolQ homologs designated ExbB - see also TIGR02797. Each group associates with a distinct group of ExbD proteins, and a single species may have two ExbB/ExbD/TonB systems. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 131852  Cd Length: 138  Bit Score: 108.33  E-value: 4.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1054590835   5 ETLKHLVDYGVIALLVIMSFIAVFFFIERVLFYKKIDVKSYKTKKALDIALTKHLTIIGTIASNSPYIGLLGTVLAIMLT 84
Cdd:TIGR02805   1 DFLKQYSDYFIFGILGLMSIIALAMVIERYLFLRKISVAHYSTIHQLDIDLNRNLTVISIIGSNAPYIGLLGTVIGIMVT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1054590835  85 FMTMGNAGDIDASKIMESLALALKATAAGLVVAIISMVFYNILSRFAEVLESDYEA 140
Cdd:TIGR02805  81 FYQMGHGGGIDPSVIMLGLSLALKATALGLLVAIPSLVFYNALLRKVEVNRLAWKV 136
TolQ COG0811
Biopolymer transport protein ExbB/TolQ [Intracellular trafficking, secretion, and vesicular ...
 14-140 4.62e-15

Biopolymer transport protein ExbB/TolQ [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440573  Cd Length: 199  Bit Score: 68.33  E-value: 4.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1054590835  14 GVIALLVIMSFIAVFFFIERVLFYKKIDVKSYK----------------------------------------------- 46
Cdd:COG0811    11 LVMIPLLLLSVLSWAIIIERLLFLRRARRRARKflraflelwsagdldeaielcearnsplarilaaglrelksgggrea 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1054590835  47 TKKALDIA-------LTKHLTIIGTIASNSPYIGLLGTVLAIMLTFMTMGNAGDIDASKIMESLALALKATAAGLVVAII 119
Cdd:COG0811    91 IERALEEAasrelprLERGLSFLATIGSIAPLLGLLGTVWGMINAFQAIAAAGQADLAVVAGGISEALITTAAGLAVAIP 170

                         170       180
                  ....*....|....*....|.
gi 1054590835 120 SMVFYNILSRFAEVLESDYEA 140
Cdd:COG0811   171 AVIAYNYFSRRIDRLVAELEE 191
MotA_ExbB pfam01618
MotA/TolQ/ExbB proton channel family; This family groups together integral membrane proteins ...
 31-135 6.10e-14

MotA/TolQ/ExbB proton channel family; This family groups together integral membrane proteins that appear to be involved translocation of proteins across a membrane. These proteins are probably proton channels. MotA is an essential component of the flageller motor that uses a proton gradient to generate rotational motion in the flageller. ExbB is part of the TonB-dependent transduction complex. The TonB complex uses the proton gradient across the inner bacterial membrane to transport large molecules across the outer bacterial membrane.


Pssm-ID: 460268  Cd Length: 120  Bit Score: 63.65  E-value: 6.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1054590835  31 IERVLFYKKID-----VKSYKTKKALDIALT-------KHLTIIGTIASNSPYIGLLGTVLAIMLTFMTMGNAGdIDASK 98
Cdd:pfam01618   5 PEDRFLKKGLQlvvdgTDPEEIRRALEEAIDreeerleRGLSILATIGSLAPLLGLLGTVLGLIHAFQNLGDAG-PGLSA 83

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1054590835  99 IMESLALALKATAAGLVVAIISMVFYNILSRFAEVLE 135
Cdd:pfam01618  84 LAPGIAEALIATAYGLFVAIPALPFYNKLKRRSEREV 120
tolQ TIGR02796
TolQ protein; TolQ is one of the essential components of the Tol-Pal system. Together with ...
 47-140 3.37e-09

TolQ protein; TolQ is one of the essential components of the Tol-Pal system. Together with TolR, it harnesses protonmotive force to energize TolA, which spans the periplasm to reach the complex of TolB and Pal at the outer member. The tol-pal system proves to be important for maintaining outer membrane integrity. Gene pairs similar to the TolQ and TolR gene pair often number several per genome, but this model describes specificially TolQ per se, as found in tol-pal operons. A close homolog, excluded from this model, is ExbB of the ExbB/ExbD/TonB protein complex, which powers transport of siderophores and vitamin B12 across the bacterial outer membrane. The Tol-Pal system is exploited by colicin and filamentous phage DNA to enter the cell. It is also implicated in pathogenesis in several bacterial species [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 131843  Cd Length: 215  Bit Score: 53.02  E-value: 3.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1054590835  47 TKKALDIA-------LTKHLTIIGTIASNSPYIGLLGTVLAIMLTFMTMGNAGD-----IDASKIMESlalaLKATAAGL 114
Cdd:TIGR02796 103 IDRAMRVAlnresekLESGLPFLATIGSTSPFIGLFGTVWGIMHSFQAIGGSKNqatlaVVAPGIAEA----LIATAIGL 178

                          90       100
                  ....*....|....*....|....*.
gi 1054590835 115 VVAIISMVFYNILSRFAEVLESDYEA 140
Cdd:TIGR02796 179 FAAIPAVIAYNKLSTQVNKIEQRYEN 204
PRK10801 PRK10801
Tol-Pal system protein TolQ;
54-139 1.33e-06

Tol-Pal system protein TolQ;


Pssm-ID: 182743  Cd Length: 227  Bit Score: 46.01  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1054590835  54 ALTKHLTIIGTIASNSPYIGLLGTVLAIMLTFMTMGNAGDIDASKIMESLALALKATAAGLVVAIISMVFYNILSRFAEV 133
Cdd:PRK10801  119 TLETHIPFLGTVGSISPYIGLFGTVWGIMHAFIALGAVKQATLQMVAPGIAEALIATAIGLFAAIPAVMAYNRLNQRVNK 198


                  ....*.
gi 1054590835 134 LESDYE 139
Cdd:PRK10801  199 LELNYD 204
PRK10414 PRK10414
biopolymer transporter ExbB;
62-129 3.63e-04

biopolymer transporter ExbB;


Pssm-ID: 236685  Cd Length: 244  Bit Score: 39.09  E-value: 3.63e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1054590835  62 IGTIASNSPYIGLLGTVLAIMLTFMTMGNAGDIDASKIMESLALALKATAAGLVVAIISMVFYNILSR 129
Cdd:PRK10414  133 LATIGAISPFVGLFGTVWGIMNSFIGIAQTQTTNLAVVAPGIAEALLATAIGLVAAIPAVVIYNVFAR 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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