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Conserved domains on  [gi|1055927728|ref|WP_067470815|]
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tautomerase family protein [Dietzia timorensis]

Protein Classification

tautomerase family protein( domain architecture ID 1755)

tautomerase family protein similar to Homo sapiens macrophage migration inhibitory factor and D-dopachrome decarboxylase-like protein

CATH:  3.30.429.10
Gene Ontology:  GO:0006725|GO:0016853
PubMed:  29184004|12051677|18695941
SCOP:  3001770

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
4Oxalocrotonate_Tautomerase super family cl00235
4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The ...
 38-115 7.06e-17

4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one dimer and the third from a neighboring monomer. Each monomer is a beta-alpha-beta fold with two small beta strands at the C-terminus that fold back on themselves. A pair of monomers form a dimer with two-fold symmetry, consisting of a 4-stranded beta sheet with two helices on one side and two additional small beta strands at each end. The dimers are assembled around a 3-fold axis of rotation to form a hexamer, with the short beta strands from each dimer contacting the neighboring dimers.


The actual alignment was detected with superfamily member pfam14552:

Pssm-ID: 444774  Cd Length: 82  Bit Score: 69.90  E-value: 7.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055927728  38 DRHVRLHVNLPHRMATSPT---LEQPDRYTLVTVDCFEGRSVDAKRALYTEIVTRF-EALGIPKDHVTIIVRDLPARNWG 113
Cdd:pfam14552   1 DRFQIIHEHDPEDFVYPPTylgIERSDDYVIIQITLFAGRSVEQKKALYRALAERLaAKLGIRPEDVFIVLVENPKENWS 80


                  ..
gi 1055927728 114 IR 115
Cdd:pfam14552  81 FG 82
 
Name Accession Description Interval E-value
Tautomerase_2 pfam14552
Tautomerase enzyme;
38-115 7.06e-17

Tautomerase enzyme;


Pssm-ID: 434035  Cd Length: 82  Bit Score: 69.90  E-value: 7.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055927728  38 DRHVRLHVNLPHRMATSPT---LEQPDRYTLVTVDCFEGRSVDAKRALYTEIVTRF-EALGIPKDHVTIIVRDLPARNWG 113
Cdd:pfam14552   1 DRFQIIHEHDPEDFVYPPTylgIERSDDYVIIQITLFAGRSVEQKKALYRALAERLaAKLGIRPEDVFIVLVENPKENWS 80


                  ..
gi 1055927728 114 IR 115
Cdd:pfam14552  81 FG 82
PptA COG1942
Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites ...
 65-116 5.03e-12

Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441545  Cd Length: 58  Bit Score: 56.70  E-value: 5.03e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1055927728  65 LVTVDCFEGRSVDAKRALYTEIVTRF-EALGIPKDHVTIIVRDLPARNWGIRG 116
Cdd:COG1942     2 IINIKLFEGRTPEQKRALAKAVTDAVvEVLGKPPESVSVVIEEVPPENWGIGG 54
4Oxalocrotonate_Tautomerase cd00491
4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The ...
 66-121 2.05e-08

4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one dimer and the third from a neighboring monomer. Each monomer is a beta-alpha-beta fold with two small beta strands at the C-terminus that fold back on themselves. A pair of monomers form a dimer with two-fold symmetry, consisting of a 4-stranded beta sheet with two helices on one side and two additional small beta strands at each end. The dimers are assembled around a 3-fold axis of rotation to form a hexamer, with the short beta strands from each dimer contacting the neighboring dimers.


Pssm-ID: 238274  Cd Length: 58  Bit Score: 47.38  E-value: 2.05e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1055927728  66 VTVDCFEGRSVDAKRAL---YTEIVTrfEALGIPKDHVTIIVRDLPARNWGIrGGHAAS 121
Cdd:cd00491     3 VQIYILEGRTDEQKRELierVTEAVS--EILGAPEATIVVIIDEMPKENWGI-GGESAS 58
PRK00745 PRK00745
4-oxalocrotonate tautomerase; Provisional
 68-116 3.98e-07

4-oxalocrotonate tautomerase; Provisional


Pssm-ID: 179107  Cd Length: 62  Bit Score: 44.32  E-value: 3.98e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1055927728  68 VDCFEGRSVDAKRALYTEIvTRF--EALGIPKDHVTIIVRDLPARNWGIRG 116
Cdd:PRK00745    6 IELFEGRTVEQKRKLVEEI-TRVtvETLGCPPESVDIIITDVKRENWATGG 55
 
Name Accession Description Interval E-value
Tautomerase_2 pfam14552
Tautomerase enzyme;
38-115 7.06e-17

Tautomerase enzyme;


Pssm-ID: 434035  Cd Length: 82  Bit Score: 69.90  E-value: 7.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055927728  38 DRHVRLHVNLPHRMATSPT---LEQPDRYTLVTVDCFEGRSVDAKRALYTEIVTRF-EALGIPKDHVTIIVRDLPARNWG 113
Cdd:pfam14552   1 DRFQIIHEHDPEDFVYPPTylgIERSDDYVIIQITLFAGRSVEQKKALYRALAERLaAKLGIRPEDVFIVLVENPKENWS 80


                  ..
gi 1055927728 114 IR 115
Cdd:pfam14552  81 FG 82
PptA COG1942
Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites ...
 65-116 5.03e-12

Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441545  Cd Length: 58  Bit Score: 56.70  E-value: 5.03e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1055927728  65 LVTVDCFEGRSVDAKRALYTEIVTRF-EALGIPKDHVTIIVRDLPARNWGIRG 116
Cdd:COG1942     2 IINIKLFEGRTPEQKRALAKAVTDAVvEVLGKPPESVSVVIEEVPPENWGIGG 54
Tautomerase pfam01361
Tautomerase enzyme; This family includes the enzyme 4-oxalocrotonate tautomerase that ...
 65-116 5.25e-09

Tautomerase enzyme; This family includes the enzyme 4-oxalocrotonate tautomerase that catalyzes the ketonization of 2-hydroxymuconate to 2-oxo-3-hexenedioate.


Pssm-ID: 396090  Cd Length: 60  Bit Score: 48.83  E-value: 5.25e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1055927728  65 LVTVDCFEGRSVDAKRAL---YTEIVTrfEALGIPKDHVTIIVRDLPARNWGIRG 116
Cdd:pfam01361   2 FVNIKLFEGRTDEQKKELierVTDALV--EVLGAPRSAIVVIIEEVPPENWGVGG 54
4Oxalocrotonate_Tautomerase cd00491
4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The ...
 66-121 2.05e-08

4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one dimer and the third from a neighboring monomer. Each monomer is a beta-alpha-beta fold with two small beta strands at the C-terminus that fold back on themselves. A pair of monomers form a dimer with two-fold symmetry, consisting of a 4-stranded beta sheet with two helices on one side and two additional small beta strands at each end. The dimers are assembled around a 3-fold axis of rotation to form a hexamer, with the short beta strands from each dimer contacting the neighboring dimers.


Pssm-ID: 238274  Cd Length: 58  Bit Score: 47.38  E-value: 2.05e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1055927728  66 VTVDCFEGRSVDAKRAL---YTEIVTrfEALGIPKDHVTIIVRDLPARNWGIrGGHAAS 121
Cdd:cd00491     3 VQIYILEGRTDEQKRELierVTEAVS--EILGAPEATIVVIIDEMPKENWGI-GGESAS 58
PRK00745 PRK00745
4-oxalocrotonate tautomerase; Provisional
 68-116 3.98e-07

4-oxalocrotonate tautomerase; Provisional


Pssm-ID: 179107  Cd Length: 62  Bit Score: 44.32  E-value: 3.98e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1055927728  68 VDCFEGRSVDAKRALYTEIvTRF--EALGIPKDHVTIIVRDLPARNWGIRG 116
Cdd:PRK00745    6 IELFEGRTVEQKRKLVEEI-TRVtvETLGCPPESVDIIITDVKRENWATGG 55
PRK02289 PRK02289
4-oxalocrotonate tautomerase; Provisional
 65-108 8.30e-05

4-oxalocrotonate tautomerase; Provisional


Pssm-ID: 179406  Cd Length: 60  Bit Score: 37.99  E-value: 8.30e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1055927728  65 LVTVDCFEGRSVDAKRAL---YTEIVTRFEalGIPKDHVTIIVRDLP 108
Cdd:PRK02289    3 FVRIDLFEGRSQEQKNALareVTEVVSRIA--KAPKEAIHVFINDMP 47
PRK02220 PRK02220
4-oxalocrotonate tautomerase; Provisional
 65-122 3.37e-04

4-oxalocrotonate tautomerase; Provisional


Pssm-ID: 235013  Cd Length: 61  Bit Score: 36.66  E-value: 3.37e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1055927728  65 LVTVDCFEGRSVDAKRAL---YTEIVTrfEALGIPKDHVTIIVRDLPARNWGIrGGHAASD 122
Cdd:PRK02220    3 YVHIKLIEGRTEEQLKALvkdVTAAVS--KNTGAPAEHIHVIINEMSKNHYAV-GGKRLSD 60
PRK01964 PRK01964
4-oxalocrotonate tautomerase; Provisional
 65-124 6.16e-04

4-oxalocrotonate tautomerase; Provisional


Pssm-ID: 179355  Cd Length: 64  Bit Score: 35.93  E-value: 6.16e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1055927728  65 LVTVDCFEGRSVDAKRALYTEIVTRFEA-LGIPKDHVTIIVRDLPARNWGIrGGHAASDID 124
Cdd:PRK01964    3 IVQIQLLEGRPEEKIKNLIREVTEAISAtLDVPKERVRVIVNEVPSSHWGV-AGVPKSELK 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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