|
Name |
Accession |
Description |
Interval |
E-value |
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
10-506 |
0e+00 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 562.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 10 LKGACGRVKLYIILVVIPAIVISFFVYEKEKDTIAAEHKQEasvlLNLHRNKINYLIgETMARMTSLSIAidrpvDIKKM 89
Cdd:COG5808 1 MKGIQKRVGLYIILVIIPTIIISAFFYEDERDKMIEENLQE----LNLYRNKLDYFI-ETLARLDSLATA-----DIKVI 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 90 QSILEKTFDSEPRFSGLYFLNAKgdvtasttelktkvnladrsfFTKAKETKKTVISDSYSSritgqpifTICVPVLDSK 169
Cdd:COG5808 71 KGILDETYDKDPRFSGLYILDES---------------------LMGAKATKKTVISSDITS--------TISAPIMDKE 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 170 rnVTDYLVAAIQIDYLKNLINLLSPDVYIEVVNQDGKMIFASGqasHAEDQKPVSGYLDDISWNMKVYPNPVTIEELTKS 249
Cdd:COG5808 122 --LTNFLLASIRMDYIRALINILDPDKYIEIVDQNGQSVFTSG---HREESKSVSNKLDKVPWEVEVYPNPVTNDELGQA 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 250 LVLPLSCIIVLLNILFILVLYYLLKRQTQLER--SENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQ 327
Cdd:COG5808 197 LAIRKLIILVLISIIFLLLQYNLLKRKTLLERviQEINTQKLELIGTFAASTAHEIRNPLTSIKGFIQLLQEKYPELEDQ 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 328 LYFSIIEQEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQyLTEQPLLVKCTKDHIKQV 407
Cdd:COG5808 277 KYFDIIQEEIQRINQIVSEFLVLGKPTAKKLELDDLNELIEEILSIIDSEANLKNIRVEKQ-SLDEPLHIKCDKDRIKQV 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 408 ILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHI 487
Cdd:COG5808 356 LLNLIKNAIEAMKEGGKLTISIENDDEKAVIEVIDNGEGIPEDIIDEIFEPFVTTKEGGTGLGLSVCKRIVEMHGGEIDI 435
|
490
....*....|....*....
gi 1119636319 488 ESEVRRGTEVTITLPVSAS 506
Cdd:COG5808 436 ESEEGKGTTFTIRLPLKKE 454
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
278-504 |
1.15e-82 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 264.53 E-value: 1.15e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 278 QLERSEneaqKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKyKGEEDQLYFSIIEQEIKRINQIVSEFLVLGKPTAEK 357
Cdd:COG5809 260 LLRKSE----KLSVVGELAAGIAHEIRNPLTSLKGFIQLLKDT-IDEEQKTYLDIMLSELDRIESIISEFLVLAKPQAIK 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 358 WELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTEQPLlVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALD-KKA 436
Cdd:COG5809 335 YEPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIPD-ILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDdDKV 413
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1119636319 437 IIKVVDNGEGISQEMLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVS 504
Cdd:COG5809 414 VISVTDEGCGIPEERLKKLGEPFYTTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIK 481
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
275-506 |
3.51e-76 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 243.60 E-value: 3.51e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 275 RQTQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIEQEIKRINQIVSEFLVLGKPT 354
Cdd:COG3852 118 ERKRLERELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQLLERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPR 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 355 AEKWELNSLQDIIGEIMPIIYSEGNlYNVEVELQYLTEQPlLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISL----- 429
Cdd:COG3852 198 PPEREPVNLHEVLERVLELLRAEAP-KNIRIVRDYDPSLP-EVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTrverq 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 430 -----GALDKKAIIKVVDNGEGISQEMLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVS 504
Cdd:COG3852 276 vtlggLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLE 355
|
..
gi 1119636319 505 AS 506
Cdd:COG3852 356 QA 357
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
273-504 |
1.36e-73 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 241.17 E-value: 1.36e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 273 LKRQTQL-ERSEneaqKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYkgEEDQLYFSIIEQEIKRINQIVSEFLVLG 351
Cdd:COG5805 271 KKEAEELmARSE----KLSIAGQLAAGIAHEIRNPLTSIKGFLQLLQPGI--EDKEEYFDIMLSELDRIESIISEFLALA 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 352 KPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTEQPLlVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGA 431
Cdd:COG5805 345 KPQAVNKEKENINELIQDVVTLLETEAILHNIQIRLELLDEDPF-IYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEE 423
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1119636319 432 LDKKAIIKVVDNGEGISQEMLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVS 504
Cdd:COG5805 424 EDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPLS 496
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
255-503 |
6.10e-71 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 230.06 E-value: 6.10e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 255 SCIIVLLNILFILVLYYLLKRQTQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIE 334
Cdd:COG5807 110 PIYYKDGVILGLITVYRDITKRKEAEDKLLRSEKLSVAGELAAGIAHEIRNPLTSIKGFLQLLQESREDSEREEYFNIII 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 335 QEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTEQPlLVKCTKDHIKQVILNVAKN 414
Cdd:COG5807 190 SEIDRINTIITELLVLSKPKKFNFKKLNLNDVLEDVIALLSTEAILKNISIKYDLADDEP-VINGDKNQLKQVFINLIKN 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 415 GLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRG 494
Cdd:COG5807 269 AIEAMETGGNITIKTYVEGDFVVISVKDEGIGIPEEVLEKIGEPFFTTKEEGTGLGLSICKKIIEEHNGTIEVESKPGKG 348
|
....*....
gi 1119636319 495 TEVTITLPV 503
Cdd:COG5807 349 TTFTIYLPL 357
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
277-506 |
3.94e-69 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 227.15 E-value: 3.94e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 277 TQLERseneAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKG------EEDQLYFSIIEQEIKRINQIVSEFLVL 350
Cdd:COG5000 190 TELLR----AERLAAWGELARRIAHEIKNPLTPIQLSAERLRRKLADkleedrEDLERALDTIIRQVDRLKRIVDEFLDF 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 351 GKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQyLTEQPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLG 430
Cdd:COG5000 266 ARLPEPQLEPVDLNELLREVLALYEPALKEKDIRLELD-LDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTR 344
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1119636319 431 ALDKKAIIKVVDNGEGISQEMLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS 506
Cdd:COG5000 345 REDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEE 420
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
252-504 |
6.59e-64 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 213.19 E-value: 6.59e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 252 LPLSCIIVLLNILFILVLYYLL--KRQTQLERSE-NEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKK-YKGEEDQ 327
Cdd:COG5806 158 LDFILYFIIIQLLAMLIAVYLIenLIENILLRKElQRAEKLEVVSELAASIAHEVRNPLTVVRGFIQLLQEPeLSDEKRK 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 328 LYFSIIEQEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQylTEQPLLVKCTKDHIKQV 407
Cdd:COG5806 238 QYIRIALEELDRAEAIITDYLTFAKPQPEKLEKIDVSEELEHVIDVLSPYANMNNVEIQTE--LEPGLYIEGDRQKLQQC 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 408 ILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHI 487
Cdd:COG5806 316 LINIIKNGIEAMPNGGTLTIDVSIDKNKVIISIKDTGVGMTKEQLERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTIRV 395
|
250
....*....|....*..
gi 1119636319 488 ESEVRRGTEVTITLPVS 504
Cdd:COG5806 396 ESEVGKGTTFTITLPLA 412
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
272-504 |
5.13e-62 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 206.96 E-value: 5.13e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 272 LLKRQTQLERSENE---AQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKY--KGEEDQL--YFSIIEQEIKRINQIV 344
Cdd:COG4191 119 LERAEEELRELQEQlvqSEKLAALGELAAGIAHEINNPLAAILGNAELLRRRLedEPDPEELreALERILEGAERAAEIV 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 345 SEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYlTEQPLLVKCTKDHIKQVILNVAKNGLESMPEG-- 422
Cdd:COG4191 199 RSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKARGIEVELDL-PPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGeg 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 423 GKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFVTSKE--KGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTIT 500
Cdd:COG4191 278 GRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKPvgKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTIT 357
|
....
gi 1119636319 501 LPVS 504
Cdd:COG4191 358 LPLA 361
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
250-504 |
1.60e-55 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 188.58 E-value: 1.60e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 250 LVLPLSCIIVLLNILFILVLYYLLKRQTQLERSEneaqklELIGTLAASTAHEIRNPLTGISGFIQLLQKKyKGEEDQLY 329
Cdd:COG0642 74 LLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEAN------EAKSRFLANVSHELRTPLTAIRGYLELLLEE-LDEEQREY 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 330 FSIIEQEIKRINQIVSEFLVLGKPTAEKWELN----SLQDIIGEIMPIIYSEGNLYNVEVELQyLTEQPLLVKCTKDHIK 405
Cdd:COG0642 147 LETILRSADRLLRLINDLLDLSRLEAGKLELEpepvDLAELLEEVVELFRPLAEEKGIELELD-LPDDLPTVRGDPDRLR 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 406 QVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFVTSKE----KGTGLGLVVCKRIVLMY 481
Cdd:COG0642 226 QVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPsrrgGGTGLGLAIVKRIVELH 305
|
250 260
....*....|....*....|...
gi 1119636319 482 GGSIHIESEVRRGTEVTITLPVS 504
Cdd:COG0642 306 GGTIEVESEPGKGTTFTVTLPLA 328
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
278-506 |
4.67e-55 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 184.73 E-value: 4.67e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 278 QLERSENEAQKLE-LIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQL--YFSIIEQEIKRINQIVSEFLVLGKPT 354
Cdd:COG2205 1 ELEEALEELEELErLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERreLLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 355 AEKWELN----SLQDIIGEIMPIIYSEGNLYNVEVELQyLTEQPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLG 430
Cdd:COG2205 81 SGKLSLElepvDLAELLEEAVEELRPLAEEKGIRLELD-LPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISAR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 431 ALDKKAIIKVVDNGEGISQEMLDHIFLPFV----TSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS 506
Cdd:COG2205 160 REGDGVRISVSDNGPGIPEEELERIFERFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAES 239
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
276-503 |
7.29e-54 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 191.33 E-value: 7.29e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 276 QTQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIEQEIKRINQIVSEFLVLGKPTA 355
Cdd:PRK11360 374 RKRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRE 453
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 356 EKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTEQPlLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGAL-DK 434
Cdd:PRK11360 454 SQWQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELP-PIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYsDG 532
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1119636319 435 KAIIKVVDNGEGISQEMLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPV 503
Cdd:PRK11360 533 QVAVSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPI 601
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
174-506 |
4.07e-51 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 178.98 E-value: 4.07e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 174 DYLVAAIQIDYLKNLINLLSPDVYIEVVNQDGKMIFASGQASHAEDQKPVSGYLDDISWNMKVYPNPVTIEELTKSLVLP 253
Cdd:COG5002 52 LALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 254 LSCIIVLLNILFILVLYYLLKRQ-TQLERSEneAQKLELIGTLAastaHEIRNPLTGISGFIQLLQKKYKGEEDQL--YF 330
Cdd:COG5002 132 GRLSLRLSALLLGLLLLAAVERDiTELERLE--QMRREFVANVS----HELRTPLTSIRGYLELLLDGAADDPEERreYL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 331 SIIEQEIKRINQIVSEFLVLGKPTAEKWELN----SLQDIIGEIMPIIYSEGNLYNVEVELQyLTEQPLLVKCTKDHIKQ 406
Cdd:COG5002 206 EIILEEAERLSRLVNDLLDLSRLESGELKLEkepvDLAELLEEVVEELRPLAEEKGIELELD-LPEDPLLVLGDPDRLEQ 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 407 VILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFV------TSKEKGTGLGLVVCKRIVLM 480
Cdd:COG5002 285 VLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYrvdksrSRETGGTGLGLAIVKHIVEA 364
|
330 340
....*....|....*....|....*.
gi 1119636319 481 YGGSIHIESEVRRGTEVTITLPVSAS 506
Cdd:COG5002 365 HGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
259-505 |
1.01e-46 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 168.81 E-value: 1.01e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 259 VLLNILF--ILVLY----YLLKRQtQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYK-GEEDQLYFS 331
Cdd:PRK10364 199 ALATVLLasLLAFFwyrrYLRSRQ-LLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERAPaGGEAHQLAQ 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 332 IIEQEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTEQPLLvKCTKDHIKQVILNV 411
Cdd:PRK10364 278 VMAKEADRLNRVVSELLELVKPTHLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPEI-QADPDRLTQVLLNL 356
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 412 AKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEV 491
Cdd:PRK10364 357 YLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQE 436
|
250
....*....|....
gi 1119636319 492 RRGTEVTITLPVSA 505
Cdd:PRK10364 437 GKGATFTLWLPVNI 450
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
272-506 |
1.01e-32 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 130.68 E-value: 1.01e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 272 LLKRQTQLERSENEaqkLEligTLAASTAHEIRNPLTGISGFIQLLQKKYKG---EEDQLYFSIIEQEIKRINQIVS--- 345
Cdd:COG4251 268 LEERTAELERSNEE---LE---QFAYVASHDLREPLRKISGFSQLLEEDYGDkldEEGREYLERIRDAAERMQALIDdll 341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 346 EFLVLGKpTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTEqpllVKCTKDHIKQVILNVAKNGLESMPEGGKL 425
Cdd:COG4251 342 AYSRVGR-QELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPT----VRGDPTLLRQVFQNLISNAIKYSRPGEPP 416
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 426 TISLGALDKK--AIIKVVDNGEGISQEMLDHIFLPFVT----SKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTI 499
Cdd:COG4251 417 RIEIGAEREGgeWVFSVRDNGIGIDPEYAEKIFEIFQRlhsrDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYF 496
|
....*..
gi 1119636319 500 TLPVSAS 506
Cdd:COG4251 497 TLPKAPA 503
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
402-504 |
1.77e-31 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 116.98 E-value: 1.77e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 402 DHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFVTSKE-----KGTGLGLVVCKR 476
Cdd:smart00387 4 DRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKrsrkiGGTGLGLSIVKK 83
|
90 100
....*....|....*....|....*...
gi 1119636319 477 IVLMYGGSIHIESEVRRGTEVTITLPVS 504
Cdd:smart00387 84 LVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
279-505 |
7.02e-29 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 120.94 E-value: 7.02e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 279 LERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYK-GEEDQLYFSIIEQEIKRINQIVSEFLVLGKPTAEK 357
Cdd:PRK13837 437 LERRLEHARRLEAVGTLASGIAHNFNNILGAILGYAEMALNKLArHSRAARYIDEIISAGARARLIIDQILAFGRKGERN 516
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 358 WELNSLQDIIGEIMPIIySEGNLYNVEVELQYlTEQPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKA- 436
Cdd:PRK13837 517 TKPFDLSELVTEIAPLL-RVSLPPGVELDFDQ-DQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAKLRAp 594
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 437 --------------IIKVVDNGEGISQEMLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLP 502
Cdd:PRK13837 595 kvlshgvlppgryvLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
|
...
gi 1119636319 503 VSA 505
Cdd:PRK13837 675 PSS 677
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
404-501 |
2.56e-28 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 108.07 E-value: 2.56e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 404 IKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFVTSK----EKGTGLGLVVCKRIVL 479
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDksreGGGTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|..
gi 1119636319 480 MYGGSIHIESEVRRGTEVTITL 501
Cdd:cd00075 81 AHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
402-503 |
3.87e-27 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 105.14 E-value: 3.87e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 402 DHIKQVILNVAKNGLESMPEGGKLTISLGAlDKKAIIKVVDNGEGISQEMLDHIFLPFVT---SKEKGTGLGLVVCKRIV 478
Cdd:pfam02518 4 LRLRQVLSNLLDNALKHAAKAGEITVTLSE-GGELTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLSIVRKLV 82
|
90 100
....*....|....*....|....*
gi 1119636319 479 LMYGGSIHIESEVRRGTEVTITLPV 503
Cdd:pfam02518 83 ELLGGTITVESEPGGGTTVTLTLPL 107
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
404-502 |
8.27e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 98.62 E-value: 8.27e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 404 IKQVILNVAKNGLESM----PEGGKLTISLGALDKKA-IIKVVDNGEGISQEMLDHIFLPFVTSKEKGTGLGLVVCKRIV 478
Cdd:cd16920 1 IQQVLINLVRNGIEAMseggCERRELTIRTSPADDRAvTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSII 80
|
90 100
....*....|....*....|....
gi 1119636319 479 LMYGGSIHIESEVRRGTEVTITLP 502
Cdd:cd16920 81 EAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
281-503 |
1.31e-23 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 102.34 E-value: 1.31e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 281 RSENEA--QKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIEQ---EIKR----INQIVSEFLVLG 351
Cdd:PRK09303 138 RQENETllEQLKFKDRVLAMLAHDLRTPLTAASLALETLELGQIDEDTELKPALIEQlqdQARRqleeIERLITDLLEVG 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 352 KPTAEKWELN-------SL-QDIIGEIMPIIYSEGnlynveveLQYLTEQPL---LVKCTKDHIKQVILNVAKNGLESMP 420
Cdd:PRK09303 218 RTRWEALRFNpqkldlgSLcQEVILELEKRWLAKS--------LEIQTDIPSdlpSVYADQERIRQVLLNLLDNAIKYTP 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 421 EGGklTISLGALDK---KAIIKVVDNGEGISQEMLDHIFLPFV----TSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRR 493
Cdd:PRK09303 290 EGG--TITLSMLHRttqKVQVSICDTGPGIPEEEQERIFEDRVrlprDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQ 367
|
250
....*....|
gi 1119636319 494 GTEVTITLPV 503
Cdd:PRK09303 368 GSCFHFTLPV 377
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
404-503 |
7.11e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 93.26 E-value: 7.11e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 404 IKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFVTSKE--KGTGLGLVVCKRIVLMY 481
Cdd:cd16943 4 LNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPvgEGTGLGLSLSYRIIQKH 83
|
90 100
....*....|....*....|..
gi 1119636319 482 GGSIHIESEVRRGTEVTITLPV 503
Cdd:cd16943 84 GGTIRVASVPGGGTRFTIILPI 105
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
185-503 |
8.10e-23 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 99.38 E-value: 8.10e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 185 LKNLIN---LLSPDVYIEVVNQDGKMIFAsgQASHAEDQKPVSGYLDDISWNMKVYPNP------VTIEELT-----KSL 250
Cdd:PRK11073 13 LNSLINsilLLDDDLAIHYANPAAQQLLA--QSSRKLFGTPLPELLSYFSLNIELMRESlqagqgFTDNEVTlvidgRSH 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 251 VLPLSCIivLLNILFILVLYYLLKRQTQLERSENE-AQKL---ELIGTLAastaHEIRNPLTGISGFIQLLQKKYKGEED 326
Cdd:PRK11073 91 ILSLTAQ--RLPEGMILLEMAPMDNQRRLSQEQLQhAQQVaarDLVRGLA----HEIKNPLGGLRGAAQLLSKALPDPAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 327 QLYFSIIEQEIKRINQIVSEFLVLGKPTAEKWElnSLQDIIGEIMPIIYSEGNlYNVEVELQYLTEQPLLVKcTKDHIKQ 406
Cdd:PRK11073 165 TEYTKVIIEQADRLRNLVDRLLGPQRPGTHVTE--SIHKVAERVVQLVSLELP-DNVRLIRDYDPSLPELAH-DPDQIEQ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 407 VILNVAKNGLESM-PEGGKLTI--------SLGALDKK--AIIKVVDNGEGISQEMLDHIFLPFVTSKEKGTGLGLVVCK 475
Cdd:PRK11073 241 VLLNIVRNALQALgPEGGTITLrtrtafqlTLHGERYRlaARIDIEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIAR 320
|
330 340
....*....|....*....|....*...
gi 1119636319 476 RIVLMYGGSIHIESEVRRgTEVTITLPV 503
Cdd:PRK11073 321 NLIDQHSGKIEFTSWPGH-TEFSVYLPI 347
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
404-503 |
5.13e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 91.02 E-value: 5.13e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 404 IKQVILNVAKNGLESMPEGG-KLTISLGALDKKAI---IKVVDNGEGISQEMLDHIFLPFV------TSKEKGTGLGLVV 473
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEvTLRVSLEEEEEDGVqlrFSVEDTGIGIPEEQQARLFEPFSqadsstTRKYGGTGLGLAI 80
|
90 100 110
....*....|....*....|....*....|
gi 1119636319 474 CKRIVLMYGGSIHIESEVRRGTEVTITLPV 503
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
274-502 |
1.00e-20 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 95.52 E-value: 1.00e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 274 KRQTQLERSENE---AQKLELIGTLAASTAHEIRNPLTGISGFI-----QLLQKKYkgEEDQLYFSIIEQEIKRINQIVS 345
Cdd:COG4192 412 RIEKNLRQTQDEliqAAKMAVVGQTMTSLAHELNQPLNAMSMYLfsakkALEQENY--AQLPTSLDKIEGLIERMDKIIK 489
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 346 EFLVLGKPTAEKWELNSLQDIIGEIMPIiysegnlynveVELQYLTEQ-------PLLVKCTKDHIKQVILNVAKNGLES 418
Cdd:COG4192 490 SLRQFSRKSDTPLQPVDLRQVIEQAWEL-----------VESRAKPQQitlhipdDLMVQGDQVLLEQVLVNLLVNALDA 558
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 419 MPEGGKLTISLGALDKKAIIKVVDNGEGIsqEMLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVT 498
Cdd:COG4192 559 VATQPQISVDLLSNAENLRVAISDNGNGW--PLVDKLFTPFTTTKEVGLGLGLSICRSIMQQFGGDLYLASTLERGAMVI 636
|
....
gi 1119636319 499 ITLP 502
Cdd:COG4192 637 LEFN 640
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
295-505 |
2.52e-20 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 93.44 E-value: 2.52e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 295 LAASTAHEIRNPLTGISgfiqlLQKKYKGEEDQ-LYFSIIEqEIKRINQIVSEFLVLGKPTAE-KWELNSLQDIIGEImp 372
Cdd:PRK09467 232 LMAGVSHDLRTPLTRIR-----LATEMMSEEDGyLAESINK-DIEECNAIIEQFIDYLRTGQEmPMEMADLNALLGEV-- 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 373 iIYSEGNlYNVEVELQyLTEQPLLVKCTKDHIKQVILNVAKNGLESmpEGGKLTISLGALDKKAIIKVVDNGEGISQEML 452
Cdd:PRK09467 304 -IAAESG-YEREIETA-LQPGPIEVPMNPIAIKRALANLVVNAARY--GNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQL 378
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1119636319 453 DHIFLPFVTSKE----KGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSA 505
Cdd:PRK09467 379 KHLFQPFTRGDSargsSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLTT 435
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
406-502 |
6.53e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 85.12 E-value: 6.53e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 406 QVILNVAKNGLESMPEGGKLTIS----LGALDKKA-----------IIKVVDNGEGISQEMLDHIFLPFVTSKE--KGTG 468
Cdd:cd16919 3 LAILNLAVNARDAMPEGGRLTIEtsnqRVDADYALnyrdlipgnyvCLEVSDTGSGMPAEVLRRAFEPFFTTKEvgKGTG 82
|
90 100 110
....*....|....*....|....*....|....
gi 1119636319 469 LGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLP 502
Cdd:cd16919 83 LGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
404-502 |
8.57e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 84.76 E-value: 8.57e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 404 IKQVILNVAKNGLESMPEGG-----------KLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFVTSKEKGTGLGLV 472
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGgeiilrtrtqrQVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGLA 80
|
90 100 110
....*....|....*....|....*....|
gi 1119636319 473 VCKRIVLMYGGSIHIESEVRRgTEVTITLP 502
Cdd:cd16918 81 IAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
300-505 |
1.84e-19 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 91.06 E-value: 1.84e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 300 AHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIEQEIKRINQIVSEFLVL----GKPTAEKWELNSLQDIIGEIMPIIY 375
Cdd:PRK11100 264 THELKSPLAAIRGAAELLQEDPPPEDRARFTGNILTQSARLQQLIDRLLELarleQRQELEVLEPVALAALLEELVEARE 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 376 SEGNLYNVEVELQyltEQPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHI 455
Cdd:PRK11100 344 AQAAAKGITLRLR---PDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRI 420
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1119636319 456 F-----LPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSA 505
Cdd:PRK11100 421 FerfysLPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRHF 475
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
275-504 |
8.69e-19 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 89.34 E-value: 8.69e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 275 RQTQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQ---KKYKGEEDQLYFSI--IEQEIKRINQIVSEFLV 349
Cdd:PRK13557 146 RRRDAEDALRQAQKMEALGQLTGGIAHDFNNLLQVMSGYLDVIQaalSHPDADRGRMARSVenIRAAAERAATLTQQLLA 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 350 LGKptAEKWE-----LNSLQDIIGEImpIIYSEGNLYNVEVELQylteqPLLVKCTKD--HIKQVILNVAKNGLESMPEG 422
Cdd:PRK13557 226 FAR--KQRLEgrvlnLNGLVSGMGEL--AERTLGDAVTIETDLA-----PDLWNCRIDptQAEVALLNVLINARDAMPEG 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 423 GKLTIS-----LGALDKKAI----------IKVVDNGEGISQEMLDHIFLPFVTSKE--KGTGLGLVVCKRIVLMYGGSI 485
Cdd:PRK13557 297 GRVTIRtrnveIEDEDLAMYhglppgryvsIAVTDTGSGMPPEILARVMDPFFTTKEegKGTGLGLSMVYGFAKQSGGAV 376
|
250
....*....|....*....
gi 1119636319 486 HIESEVRRGTEVTITLPVS 504
Cdd:PRK13557 377 RIYSEVGEGTTVRLYFPAS 395
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
273-502 |
5.16e-18 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 85.67 E-value: 5.16e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 273 LKRQTQLERSENEAQKLE-LIGTLAASTaHEIRNPLTGISGFIQLlqKKYkgEEDQLYfsiIEQEIKRINQIVSEFLVLG 351
Cdd:COG3290 170 FRDRTELERLEEELEGVKeLAEALRAQR-HDFRNHLHTISGLLQL--GEY--DEALEY---IDEISEELQELIDSLLSRI 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 352 KPTAekweLNSLqdIIGEimpiiYSEGNLYNVEVELQ---YLTEQPLLVkctkDHIKQVILNVAKNGLESM----PEGGK 424
Cdd:COG3290 242 GNPV----LAAL--LLGK-----AARARERGIDLTIDidsDLPDLPLSD----TDLVTILGNLLDNAIEAVeklpEEERR 306
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1119636319 425 LTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFVTSK-EKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLP 502
Cdd:COG3290 307 VELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKlGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLP 385
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
404-502 |
7.71e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 79.12 E-value: 7.71e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 404 IKQVILNVAKNGLESMpEGGKLTISLGALDKKA------IIKVVDNGEGISQEMLDHIFLPFVTSKEKGTGLGLVVCKRI 477
Cdd:cd16944 5 ISQVLTNILKNAAEAI-EGRPSDVGEVRIRVEAdqdgriVLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIVKKI 83
|
90 100
....*....|....*....|....*
gi 1119636319 478 VLMYGGSIHIESEVRRGTEVTITLP 502
Cdd:cd16944 84 MEEHGGRISLSNREAGGACIRIILP 108
|
|
| dCache_1 |
pfam02743 |
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ... |
41-211 |
2.01e-15 |
|
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 460673 [Multi-domain] Cd Length: 237 Bit Score: 75.84 E-value: 2.01e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 41 DTIAAEHKQEASVLLNLHRNKINYLIG------ETMARMTSLSIAIDRPVDIKKMQsiLEKTFDSEPRFSGLYFLNAKGD 114
Cdd:pfam02743 1 KAIKEQAEEQLLSLAKQLAENIESYLDsleeilELLASNPDLQDLLSAPAEEELAK--LESLLRSNPGISSIYLVDADGR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 115 VTASTTE--LKTKVNLADRSFFTKAKETKK---TVISDSYSSRITGQPIFTICVPVLDSKRNVTDYLVAAIQIDYLKNLI 189
Cdd:pfam02743 79 VLASSDEspSYPGLDVSERPWYKEALKGGGgiiWVFSSPYPSSESGEPVLTIARPIYDDDGEVIGVLVADLDLDTLQELL 158
|
170 180
....*....|....*....|....
gi 1119636319 190 N--LLSPDVYIEVVNQDGKMIFAS 211
Cdd:pfam02743 159 SqiKLGEGGYVFIVDSDGRILAHP 182
|
|
| PDC1_DGC_like |
cd12914 |
first PDC (PhoQ/DcuS/CitA) domain of diguanylate-cyclase and similar domains; Members of this ... |
74-180 |
2.38e-15 |
|
first PDC (PhoQ/DcuS/CitA) domain of diguanylate-cyclase and similar domains; Members of this subfamily display varying domain architectures but all contain double PDC (PhoQ/DcuS/CitA) sensor domains. This model represents the first PDC domain of Diguanylate-cyclases (DGCs), Histidine kinases (HKs), and other similar domains. Many members of this subfamily contain a C-terminal DGC (also called GGDEF) domain. DGCs regulate the turnover of cyclic diguanosine monophosphate. HK receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. In the case of HKs, signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses.
Pssm-ID: 350339 Cd Length: 123 Bit Score: 72.42 E-value: 2.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 74 TSLSIAIDRPVDIKKMQSILEKTFDSEPRFSGLYFLNAKGDVTASTTE-LKTKVNLADRSFFTKAKET-KKTVISDSYSS 151
Cdd:cd12914 13 DDLEARGAASADPAALQALLRRLLARLPEVRSIFVVDADGRVVASSGPgPAPGLDVSDRDYFQAARAGgGGLFISEPVIS 92
|
90 100
....*....|....*....|....*....
gi 1119636319 152 RITGQPIFTICVPVLDSKRNVTDYLVAAI 180
Cdd:cd12914 93 RVTGKPVIPLSRPIRDADGRFAGVVVASI 121
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
297-503 |
4.18e-15 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 78.62 E-value: 4.18e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 297 ASTAHEIRNPLTGISGFIQLLQKKYKGEEDQL-YFSIIEQEIKRINQIVSEFLVLGKPTAEKWELN-SLQDIIGEIMPII 374
Cdd:PRK09959 717 ATMSHEIRTPISSIMGFLELLSGSGLSKEQRVeAISLAYATGQSLLGLIGEILDVDKIESGNYQLQpQWVDIPTLVQNTC 796
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 375 YSEGNLY-NVEVELQYLTEQP--LLVKCTKDHIKQVILNVAKNGLESMPEGG-KLTISLGALDKK-AIIK--VVDNGEGI 447
Cdd:PRK09959 797 HSFGAIAaSKSIALSCSSTFPdhYLVKIDPQAFKQVLSNLLSNALKFTTEGAvKITTSLGHIDDNhAVIKmtIMDSGSGL 876
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 448 SQEMLDHIFLPFVTS----KEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPV 503
Cdd:PRK09959 877 SQEEQQQLFKRYSQTsagrQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPV 936
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
293-356 |
5.41e-15 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 69.55 E-value: 5.41e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1119636319 293 GTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIEQEIKRINQIVSEFLVLGKPTAE 356
Cdd:pfam00512 3 SEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
401-502 |
9.44e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 70.18 E-value: 9.44e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 401 KDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFV---TSKEK---GTGLGLVVC 474
Cdd:cd16946 2 RDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYrveSSRNRasgGSGLGLAIC 81
|
90 100
....*....|....*....|....*...
gi 1119636319 475 KRIVLMYGGSIHIESEVRRGTEVTITLP 502
Cdd:cd16946 82 HNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PDC1_HK_sensor |
cd18773 |
first PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins, diguanylate-cyclase ... |
68-182 |
1.93e-14 |
|
first PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins, diguanylate-cyclase and similar domains; Histidine kinase (HK) receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. HK receptors in this family contain double PDC (PhoQ/DcuS/CitA) sensor domains. Signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses. The HK family includes not just histidine kinase receptors but also sensors for chemotaxis proteins and diguanylate cyclase receptors, implying a combinatorial molecular evolution.
Pssm-ID: 350341 [Multi-domain] Cd Length: 125 Bit Score: 69.90 E-value: 1.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 68 ETMARMTSLSIAI---DRPVDIKKMQSILEKTFDSEPRFSGLYFLNAKGDVTASTTELKTKVNLADRS---FFTKAKETK 141
Cdd:cd18773 5 DLLLRSLASALEAlaaLGSADREELQALLRRLLERNPEISGIYVVDADGRVVASSDRDPGGGDDDDDRdrfWYQAAKATG 84
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1119636319 142 KTVISDSYSSRITGQPIFTICVPVLDSKRNVTDYLVAAIQI 182
Cdd:cd18773 85 KLVISEPYISRVTGKPVITLSRPIRDADGRFIGVVGADIDL 125
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
275-503 |
5.95e-14 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 74.56 E-value: 5.95e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 275 RQTQLERSENEAQKleliGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSII----EQEIKRINQIV--SEFL 348
Cdd:PRK11466 431 RQARAEAEKASQAK----SAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRAItdsgESLLTILNDILdySAIE 506
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 349 VLGKPTA---EKWELNSLQDIIGEIMpiiysEGNLYNVEVEL--QYLTEQPLLVKCTKDHIKQVILNVAKNGLEsMPEGG 423
Cdd:PRK11466 507 AGGKNVSvsdEPFEPRPLLESTLQLM-----SGRVKGRPIRLatDIADDLPTALMGDPRRIRQVITNLLSNALR-FTDEG 580
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 424 KLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFV--TSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITL 501
Cdd:PRK11466 581 SIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVqvSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRL 660
|
..
gi 1119636319 502 PV 503
Cdd:PRK11466 661 PL 662
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
293-356 |
7.55e-14 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 66.05 E-value: 7.55e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1119636319 293 GTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIEQEIKRINQIVSEFLVLGKPTAE 356
Cdd:smart00388 3 REFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
265-505 |
8.22e-14 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 74.30 E-value: 8.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 265 FILVLYYLLKRQTQLERSEN---EAQKLELIGTLAASTAHEIRNPLTGISGFIQLL-------QKKYKGEEDQlyfsiIE 334
Cdd:PRK10490 634 FTLLIANALERLTLTASEEQarlASEREQLRNALLAALSHDLRTPLTVLFGQAEILtldlaseGSPHARQASE-----IR 708
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 335 QEIKRINQIVSEFLVLGKPTAEKWELN----SLQDIIGEIMPIIysEGNLYNVEVELQyLTEQPLLVKCTKDHIKQVILN 410
Cdd:PRK10490 709 QQVLNTTRLVNNLLDMARIQSGGFNLRkewlTLEEVVGSALQML--EPGLSGHPINLS-LPEPLTLIHVDGPLFERVLIN 785
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 411 VAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFVT-SKEK---GTGLGLVVCKRIVLMYGGSIH 486
Cdd:PRK10490 786 LLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARgNKESaipGVGLGLAICRAIVEVHGGTIW 865
|
250
....*....|....*....
gi 1119636319 487 IESEVRRGTEVTITLPVSA 505
Cdd:PRK10490 866 AENRPEGGACFRVTLPLET 884
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
404-501 |
1.18e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 66.71 E-value: 1.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 404 IKQVILNVAKNGLESMP--EGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFVTSKEKG--TGLGLVVCKRIVL 479
Cdd:cd16976 1 IQQVLMNLLQNALDAMGkvENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGkgTGLGLSISYGIVE 80
|
90 100
....*....|....*....|..
gi 1119636319 480 MYGGSIHIESEVRRGTEVTITL 501
Cdd:cd16976 81 EHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
404-502 |
1.31e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 66.70 E-value: 1.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 404 IKQVILNVAKNGLESmpEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFVTSKE----KGTGLGLVVCKRIVL 479
Cdd:cd16950 1 LKRVLSNLVDNALRY--GGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNargtSGTGLGLAIVQRISD 78
|
90 100
....*....|....*....|...
gi 1119636319 480 MYGGSIHIESEVRRGTEVTITLP 502
Cdd:cd16950 79 AHGGSLTLANRAGGGLCARIELP 101
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
415-503 |
1.46e-13 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 72.74 E-value: 1.46e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 415 GLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFvTSKEKGTGLGLV-VCKRIVLMYGG--SIHIESEV 491
Cdd:COG2972 352 GIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-SSKGEGRGIGLRnVRERLKLYYGEeyGLEIESEP 430
|
90
....*....|..
gi 1119636319 492 RRGTEVTITLPV 503
Cdd:COG2972 431 GEGTTVTIRIPL 442
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
404-502 |
1.74e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 66.58 E-value: 1.74e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 404 IKQVILNVAKNGLESMPEggKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPF------VTSKEKGTGLGLVVCKRI 477
Cdd:cd16949 1 LARALENVLRNALRYSPS--KILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFyrvdsaRDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*
gi 1119636319 478 VLMYGGSIHIESEVRRGTEVTITLP 502
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-501 |
2.21e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 66.77 E-value: 2.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 381 YNVEVELQyltEQPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFV 460
Cdd:cd16947 1 FQVEINIP---DRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLY 77
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1119636319 461 TSKE------KGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITL 501
Cdd:cd16947 78 TLEDsrnsakQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
289-352 |
4.05e-13 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 64.16 E-value: 4.05e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1119636319 289 LELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQL-YFSIIEQEIKRINQIVSEFLVLGK 352
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQReYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
401-501 |
7.48e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 65.12 E-value: 7.48e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 401 KDHIKQVILNVAKNGLESMPEGGKLTISLGALDKkAIIKVVDNGEGISQEMLDHIFLPFVTS---KEKGTGLGLVVCKRI 477
Cdd:cd16940 11 ALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDG-AVIRVEDNGPGIDEEELEALFERFYRSdgqNYGGSGLGLSIVKRI 89
|
90 100
....*....|....*....|....
gi 1119636319 478 VLMYGGSIHIESEVRRGTEVTITL 501
Cdd:cd16940 90 VELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
404-502 |
2.74e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 63.11 E-value: 2.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 404 IKQVILNVAKNGLESMPEGGKLTISLGALD--KKAIIKVVDNGEGISQEMLDHIFLPF----VTSKEKGTGLGLVVCKRI 477
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDvgEEWTFYVRDNGIGIDPEYAEKVFGIFqrlhSREEYEGTGVGLAIVRKI 80
|
90 100
....*....|....*....|....*
gi 1119636319 478 VLMYGGSIHIESEVRRGTEVTITLP 502
Cdd:cd16921 81 IERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
406-502 |
6.75e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 62.06 E-value: 6.75e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 406 QVIL-NVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFVTSkEKGTGLGLV-VCKRIVLMYG- 482
Cdd:cd16957 7 QVLVeNAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTS-EKGTGTALEnLNRRLIGLFGs 85
|
90 100
....*....|....*....|.
gi 1119636319 483 -GSIHIESEVRRGTEVTITLP 502
Cdd:cd16957 86 eACLHIESEVHGGTEVWFVIP 106
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
397-502 |
1.55e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 61.15 E-value: 1.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 397 VKCTKDHIKQVIlnvaKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFVTSK-----EKGTGLGL 471
Cdd:cd16948 3 AKWLSFIIGQIV----SNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGEngrnfQESTGMGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 1119636319 472 VVCKRIVLMYGGSIHIESEVRRGTEVTITLP 502
Cdd:cd16948 79 YLVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
296-502 |
1.58e-11 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 66.33 E-value: 1.58e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 296 AASTAHEIRNPLTGI--SGFIQLLQKKYKGE-EDQLYFSIieQEIKRINQIVSEFLVLGKPTAEKWELNSLQ-DIIGEIM 371
Cdd:PRK09835 266 SADIAHEIRTPITNLitQTEIALSQSRSQKElEDVLYSNL--EELTRMAKMVSDMLFLAQADNNQLIPEKKMlDLADEVG 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 372 PII-YSEGNLYNVEVELQYlTEQPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQE 450
Cdd:PRK09835 344 KVFdFFEAWAEERGVELRF-VGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPE 422
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1119636319 451 MLDHIFLPFV------TSKEKGTGLGLVVCKRIVLMYGGSIHIESEVrRGTEVTITLP 502
Cdd:PRK09835 423 HLPRLFDRFYrvdpsrQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLP 479
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
407-502 |
2.50e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 60.38 E-value: 2.50e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 407 VILNVAKNGLE---SMPEGGK-LTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFVTSKE-KGTGLGLVVCKRIVLMY 481
Cdd:cd16915 4 IVGNLIDNALDalaATGAPNKqVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGqGERGIGLALVRQSVERL 83
|
90 100
....*....|....*....|.
gi 1119636319 482 GGSIHIESEVRRGTEVTITLP 502
Cdd:cd16915 84 GGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
406-502 |
2.58e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 60.66 E-value: 2.58e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 406 QVILNVAKNGLE-SMPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFVTSKEKG------TGLGLVVCKRIV 478
Cdd:cd16953 3 QVLRNLIGNAISfSPPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANeafgqhSGLGLSISRQII 82
|
90 100
....*....|....*....|....*...
gi 1119636319 479 LMYGGSIHIES----EVRRGTEVTITLP 502
Cdd:cd16953 83 EAHGGISVAENhnqpGQVIGARFTVQLP 110
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
297-502 |
2.75e-11 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 65.42 E-value: 2.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 297 ASTAHEIRNPLTGISGFIQLLQKK-YKGEEDQLYFSIIEQEIKRINQIVSEFLVLGK-PTAEKWELNSLQDIigeimPII 374
Cdd:PRK11006 209 ANVSHELRTPLTVLQGYLEMMQDQpLEGALREKALHTMREQTQRMEGLVKQLLTLSKiEAAPTIDLNEKVDV-----PMM 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 375 ysegnLYNVEVELQYLTEQ----------PLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNG 444
Cdd:PRK11006 284 -----LRVLEREAQTLSQGkhtitfevdnSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNG 358
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1119636319 445 EGISQEMLDHIFLPF-----VTSKEK-GTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLP 502
Cdd:PRK11006 359 PGIAPEHIPRLTERFyrvdkARSRQTgGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
410-502 |
3.01e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 60.15 E-value: 3.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 410 NVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGIsqemlDHIFLPFVTSKE-KGTGLGLV-VCKRIVLMYGG--SI 485
Cdd:cd16924 12 NAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGI-----DPKVLNILGKKPkEGNGIGLYnVHQRLILLFGEdyGI 86
|
90
....*....|....*..
gi 1119636319 486 HIESEVRRGTEVTITLP 502
Cdd:cd16924 87 HIASEPDKGTRITFTIP 103
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
402-502 |
2.55e-10 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 57.50 E-value: 2.55e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 402 DHIKQVILNVAKNGLESMPEGGKLTISLGALD-KKAIIKVVDNGEGISQEMLDHIFLPF------VTSKEKGTGLGLVVC 474
Cdd:cd16925 3 EKYERVVLNLLSNAFKFTPDGGRIRCILEKFRlNRFLLTVSDSGPGIPPNLREEIFERFrqgdgsSTRAHGGTGLGLSIV 82
|
90 100
....*....|....*....|....*...
gi 1119636319 475 KRIVLMYGGSIHIESEVRRGTEVTITLP 502
Cdd:cd16925 83 KEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
404-501 |
3.07e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 57.47 E-value: 3.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 404 IKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIF-----LPFVTSKEKGTGLGLVVCKRIV 478
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFerfysLPRPHSGQKSTGLGLAFVQEVA 84
|
90 100
....*....|....*....|...
gi 1119636319 479 LMYGGSIHIESeVRRGTEVTITL 501
Cdd:cd16945 85 QLHGGRITLRN-RPDGVLAFLTL 106
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
402-506 |
1.04e-09 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 60.42 E-value: 1.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 402 DHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFV---TSKEK---GTGLGLVVCK 475
Cdd:PRK10549 351 DRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYrteGSRNRasgGSGLGLAICL 430
|
90 100 110
....*....|....*....|....*....|.
gi 1119636319 476 RIVLMYGGSIHIESEVRRGTEVTITLPVSAS 506
Cdd:PRK10549 431 NIVEAHNGRIIAAHSPFGGVSITVELPLERD 461
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
250-506 |
1.11e-09 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 58.86 E-value: 1.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 250 LVLPLSCIIVLLNILFILVLYYLLKRQTQLERSENEAQKLELIGTLAA-----------STAHEirnpLTGISGFIQLLQ 318
Cdd:COG4585 5 ALLGALALLVGALLGLLLALVLLRARRAERAAELERELAARAEEAREEerrriarelhdGVGQS----LSAIKLQLEAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 319 KKYKGEEDQLyfsiiEQEIKRINQIVSEflvlgkptaekwELNSLQDIIGEIMPIIYSEGNL--------------YNVE 384
Cdd:COG4585 81 RLLDADPEAA-----REELEEIRELARE------------ALAELRRLVRGLRPPALDDLGLaaaleelaerllraAGIR 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 385 VELQYLTEQPLLvkctKDHIKQVIL--------NVAKNGlesmpEGGKLTISLGALDKKAIIKVVDNGEGisqemldhif 456
Cdd:COG4585 144 VELDVDGDPDRL----PPEVELALYrivqealtNALKHA-----GATRVTVTLEVDDGELTLTVRDDGVG---------- 204
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1119636319 457 lpFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS 506
Cdd:COG4585 205 --FDPEAAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
296-502 |
1.82e-09 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 59.21 E-value: 1.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 296 AASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLyfsiieqeIKRINQI---VSEFLVL---------GKPTAEKWelnsL 363
Cdd:PRK10755 141 TADVAHELRTPLAGIRLHLELLEKQHHIDVAPL--------IARLDQMmhtVEQLLQLaragqsfssGHYQTVKL----L 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 364 QDIIgeiMPiiysegnLYNVEVELQYLTEQPLLVKCTKDHIK--------QVIL-NVAKNGLESMPEGGKLTISLGALDK 434
Cdd:PRK10755 209 EDVI---LP-------SQDELSEMLEQRQQTLLLPESAADITvqgdatllRLLLrNLVENAHRYSPEGSTITIKLSQEDG 278
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1119636319 435 KAIIKVVDNGEGISQEMLDHIFLPFV--TSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRR-GTEVTITLP 502
Cdd:PRK10755 279 GAVLAVEDEGPGIDESKCGELSKAFVrmDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQERsGTRAWVWLP 349
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
407-502 |
1.84e-09 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 59.93 E-value: 1.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 407 VILNVAKNGLESMP--EGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGS 484
Cdd:PRK11086 437 ILGNLIENALEAVGgeEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGGS 516
|
90
....*....|....*...
gi 1119636319 485 IHIESEVRRGTEVTITLP 502
Cdd:PRK11086 517 IAVESEPGVGTQFFVQIP 534
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
293-506 |
2.12e-09 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 59.95 E-value: 2.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 293 GTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIEQEIKRINQIVSEFLVLGKPTAEKWEL-NSLQDIIGEIM 371
Cdd:PRK11091 284 TTFISTISHELRTPLNGIVGLSRILLDTELTAEQRKYLKTIHVSAITLGNIFNDIIDMDKMERRKLQLdNQPIDFTDFLA 363
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 372 PIIysegNLYNVEVE---LQYLTE--QPLLVKCTKD--HIKQVILNVAKNGLESMPEGGkLTISLGALDKKAI-IKVVDN 443
Cdd:PRK11091 364 DLE----NLSGLQAEqkgLRFDLEplLPLPHKVITDgtRLRQILWNLISNAVKFTQQGG-VTVRVRYEEGDMLtFEVEDS 438
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 444 GEGISQEMLDHIFLPFVTSKEK-------GTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS 506
Cdd:PRK11091 439 GIGIPEDELDKIFAMYYQVKDShggkpatGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHAPAV 508
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
297-502 |
2.65e-09 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 59.99 E-value: 2.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 297 ASTAHEIRNPLTGISGFIQLLQKKYKGEE--------------------DQLYFSIIEQEIKRINqiVSEFlvlgkptae 356
Cdd:PRK10841 452 ATVSHELRTPLYGIIGNLDLLQTKELPKGvdrlvtamnnssslllkiisDILDFSKIESEQLKIE--PREF--------- 520
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 357 kwelnSLQDIIGEIMpiiyseGNlynvevelqYLteqPLLVK------CTKDH------------IKQVILNVAKNGLEs 418
Cdd:PRK10841 521 -----SPREVINHIT------AN---------YL---PLVVKkrlglyCFIEPdvpvalngdpmrLQQVISNLLSNAIK- 576
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 419 MPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPF------VTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVR 492
Cdd:PRK10841 577 FTDTGCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFfqvgtgVQRNFQGTGLGLAICEKLINMMDGDISVDSEPG 656
|
250
....*....|
gi 1119636319 493 RGTEVTITLP 502
Cdd:PRK10841 657 MGSQFTIRIP 666
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
274-505 |
3.42e-09 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 59.66 E-value: 3.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 274 KRQTQLERSENEAQ-----KLELIGTLAastaHEIRNPLTGISGFIQLLQKkykGEEDQLYFSIIEQEIKRINQ---IVS 345
Cdd:PRK15347 379 ERTQALAEAKQRAEqankrKSEHLTTIS----HEIRTPLNGVLGALELLQN---TPLTAEQMDLADTARQCTLSllaIIN 451
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 346 EFLVLGKPTAEKWELN----SLQDIIGEIMPIIYSEG-----NLY---NVEVELQYLTEqPLLVKctkdhikQVILNVAK 413
Cdd:PRK15347 452 NLLDFSRIESGQMTLSleetALLPLLDQAMLTIQGPAqskslTLRtfvGAHVPLYLHLD-SLRLR-------QILVNLLG 523
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 414 NGLESMPEGGkltISL--GALDKKAIIKVVDNGEGISQEMLDHIFLPFVTSK--EKGTGLGLVVCKRIVLMYGGSIHIES 489
Cdd:PRK15347 524 NAVKFTETGG---IRLrvKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADthSQGTGLGLTIASSLAKMMGGELTLFS 600
|
250
....*....|....*.
gi 1119636319 490 EVRRGTEVTITLPVSA 505
Cdd:PRK15347 601 TPGVGSCFSLVLPLNE 616
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
297-502 |
4.40e-09 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 59.09 E-value: 4.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 297 ASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIEQEIKRINQIVSEFLVLGKPTAEKWELN----SLQDIIGEIMP 372
Cdd:PRK11107 298 ANMSHELRTPLNGVIGFTRQTLKTPLTPTQRDYLQTIERSANNLLAIINDILDFSKLEAGKLVLEnipfSLRETLDEVVT 377
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 373 IIYSEGNLYNVEVELQ-------YLTEQPLlvkctkdHIKQVILNVAKNGLESMPEGG-KLTISLGALDKKAI---IKVV 441
Cdd:PRK11107 378 LLAHSAHEKGLELTLNidpdvpdNVIGDPL-------RLQQIITNLVGNAIKFTESGNiDILVELRALSNTKVqleVQIR 450
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1119636319 442 DNGEGISQEMLDHIFLPF------VTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLP 502
Cdd:PRK11107 451 DTGIGISERQQSQLFQAFrqadasISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLP 517
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
402-499 |
9.10e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 53.23 E-value: 9.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 402 DHIKQVILNVAKNGLESMPEGGklTISLGALDKKAIIK--VVDNGEGISQEMLDHIFLPFVTSKEKGT-----GLGLVVC 474
Cdd:cd16975 3 LLLSRALINIISNACQYAPEGG--TVSISIYDEEEYLYfeIWDNGHGFSEQDLKKALELFYRDDTSRRsgghyGMGLYIA 80
|
90 100
....*....|....*....|....*
gi 1119636319 475 KRIVLMYGGSIHIESEVRRGTEVTI 499
Cdd:cd16975 81 KNLVEKHGGSLIIENSQKGGAEVTV 105
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
295-502 |
1.25e-08 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 57.25 E-value: 1.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 295 LAASTAHEIRNPLTGISGFIQLLQKKyKGEEDQLyfSIIEQEIKRINQIVSEFLVLGKpTAEKWELNSlqdiigEIMPI- 373
Cdd:PRK09470 246 LLSDISHELRTPLTRLQLATALLRRR-QGESKEL--ERIETEAQRLDSMINDLLVLSR-NQQKNHLER------ETFKAn 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 374 -IYSEgNLYNVEVELqyltEQPLLVKCTKDHIKQVILNVAKNGLESMPEG--------GKLTISLG-ALDKKAI-IKVVD 442
Cdd:PRK09470 316 sLWSE-VLEDAKFEA----EQMGKSLTVSAPPGPWPINGNPNALASALENivrnalrySHTKIEVAfSVDKDGLtITVDD 390
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1119636319 443 NGEGISQEMLDHIFLPFVTSKEK------GTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLP 502
Cdd:PRK09470 391 DGPGVPEEEREQIFRPFYRVDEArdresgGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLP 456
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
292-503 |
2.04e-08 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 56.54 E-value: 2.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 292 IGTLAAS-------TAHEIRNPLTGISGFIQLLQKKYKGEEDQLyfsiiEQEIKRINQIVSEFLVLGK------------ 352
Cdd:PRK10604 205 INALIASkkqlidgIAHELRTPLVRLRYRLEMSDNLSAAESQAL-----NRDIGQLEALIEELLTYARldrpqnelhlse 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 353 PTAEKWelnsLQDIIGEIMPIiysegnlyNVEVEL--------QYLTEQPLLvkctkdhIKQVILNVAKNGLESmpEGGK 424
Cdd:PRK10604 280 PDLPAW----LSTHLADIQAV--------TPEKTVrldtphqgDYGALDMRL-------MERVLDNLLNNALRY--AHSR 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 425 LTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFV---TSKEKGT---GLGLVVCKRIVLMYGGSIHIESEVRRGTEVT 498
Cdd:PRK10604 339 VRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVrldPSRDRATggcGLGLAIVHSIALAMGGSVNCDESELGGARFS 418
|
....*
gi 1119636319 499 ITLPV 503
Cdd:PRK10604 419 FSWPV 423
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
404-502 |
7.69e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 50.66 E-value: 7.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 404 IKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFV------TSKEKGTGLGLVVCKRI 477
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYrvdierCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*
gi 1119636319 478 VLMYGGSIHIESEVRRGTEVTITLP 502
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFP 105
|
|
| HATPase_YehU-like |
cd16956 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
404-502 |
8.28e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.
Pssm-ID: 340432 [Multi-domain] Cd Length: 101 Bit Score: 50.13 E-value: 8.28e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 404 IKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPfvtsKEKGTGLGLVVcKRIVLMYGG 483
Cdd:cd16956 6 LQPIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMDPDTLARILIR----SSNGLGLNLVD-KRLRQAFGN 80
|
90 100
....*....|....*....|.
gi 1119636319 484 S--IHIESEVRRGTEVTITLP 502
Cdd:cd16956 81 DygLDIECAPGEGTRITIRLP 101
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
407-503 |
1.11e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 50.12 E-value: 1.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 407 VILNVAKNGLESMPEggKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFV------TSKEKGTGLGLVVCKRIVLM 480
Cdd:cd16939 4 ALDNLLRNALRYAHR--TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVrldpsrDRATGGFGLGLAIVHRVALW 81
|
90 100
....*....|....*....|...
gi 1119636319 481 YGGSIHIESEVRRGTEVTITLPV 503
Cdd:cd16939 82 HGGHVECDDSELGGACFRLTWPR 104
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
410-502 |
2.64e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 48.32 E-value: 2.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 410 NVAKNGlesmpEGGKLTISLGALDKKAIIKVVDNGEGISQEmldhiflpfvtSKEKGTGLGLVVCKRIVLMYGGSIHIES 489
Cdd:cd16917 11 NALKHA-----GASRVRVTLSYTADELTLTVVDDGVGFDGP-----------APPGGGGFGLLGMRERAELLGGTLTIGS 74
|
90
....*....|...
gi 1119636319 490 EVRRGTEVTITLP 502
Cdd:cd16917 75 RPGGGTRVTARLP 87
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
300-500 |
4.13e-07 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 52.34 E-value: 4.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 300 AHEIRNPLTGI---SGFIQLLQKKYKGEEDQLyfSIIEQEIKRINQIVSEFLVLGKptaekweLNSLqDIIGEIMPI--- 373
Cdd:PRK10337 245 AHELRSPLAALkvqTEVAQLSDDDPQARKKAL--LQLHAGIDRATRLVDQLLTLSR-------LDSL-DNLQDVAEIple 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 374 ---------IYSEGNLYNVEVELQY------LTEQPLLVKCtkdhikqVILNVAKNGLESMPEGGKLTISLGAldkkAII 438
Cdd:PRK10337 315 dllqsavmdIYHTAQQAGIDVRLTLnahpviRTGQPLLLSL-------LVRNLLDNAIRYSPQGSVVDVTLNA----RNF 383
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1119636319 439 KVVDNGEGISQEMLDHI----FLPfvTSKEK-GTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTIT 500
Cdd:PRK10337 384 TVRDNGPGVTPEALARIgerfYRP--PGQEAtGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKVS 448
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
420-502 |
4.71e-07 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 49.89 E-value: 4.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 420 PEGGKLTISLGALDKKAIIKVVDNGEGI------------------------SQEMLDHIFLP-FVTSKE----KGTGLG 470
Cdd:cd16916 67 PPEGTITLRAEHQGNQVVIEVSDDGRGIdrekirekaierglitadeaatlsDDEVLNLIFAPgFSTAEQvtdvSGRGVG 146
|
90 100 110
....*....|....*....|....*....|..
gi 1119636319 471 LVVCKRIVLMYGGSIHIESEVRRGTEVTITLP 502
Cdd:cd16916 147 MDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
421-505 |
1.66e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 50.67 E-value: 1.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 421 EGGKLTISLGALDKKAIIKVVDNGEGisqemldhifLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEvrRGTEVTIT 500
Cdd:COG3920 420 EGGRIRVSWRREDGRLRLTVSDNGVG----------LPEDVDPPARKGLGLRLIRALVRQLGGTLELDRP--EGTRVRIT 487
|
....*
gi 1119636319 501 LPVSA 505
Cdd:COG3920 488 FPLAE 492
|
|
| HATPase_YpdA-like |
cd16955 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
404-502 |
2.12e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340431 [Multi-domain] Cd Length: 102 Bit Score: 46.30 E-value: 2.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 404 IKQVILNVAKNGLESMPEGGKLTISLGA-LDKKAIIKVVDNGEGISQEMLDHIFlpfvTSKEKGTGLGLV-VCKRIVLMY 481
Cdd:cd16955 6 IQPLVENAIVHGIQEKKGKGVVKISVKKqLKNRLHIAVEDNGIGISPKVIERVE----QDEMPGNKIGLLnVHQRLKLGY 81
|
90 100
....*....|....*....|.
gi 1119636319 482 GGSIHIESEVRRGTEVTITLP 502
Cdd:cd16955 82 GEGLHIRSRPDPGTLIAFYIP 102
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
421-504 |
8.03e-06 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 48.25 E-value: 8.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 421 EGGKLTISL---GA-LDKKAII-KVVDNG-------EGIS-QEMLDHIFLPFVTSKEK-----GTGLGL-VVCKRIVLMy 481
Cdd:COG0643 318 EGGRVVIEVsddGRgLDLEKIRaKAIEKGlitaeeaAALSdEELLELIFAPGFSTAEEvtdlsGRGVGMdVVKTNIEAL- 396
|
90 100
....*....|....*....|...
gi 1119636319 482 GGSIHIESEVRRGTEVTITLPVS 504
Cdd:COG0643 397 GGTIEIESEPGKGTTFTLRLPLT 419
|
|
| PDC1_MCP_like |
cd12913 |
first PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins and similar domains; ... |
63-167 |
2.23e-05 |
|
first PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins and similar domains; Members of this subfamily display varying domain architectures but all contain double PDC (PhoQ/DcuS/CitA) sensor domains. This model represents the first PDC domain of Methyl-accepting chemotaxis proteins (MCPs), Histidine kinases (HKs), and other similar domains. Many members contain both HAMP (HK, Adenylyl cyclase, MCP, and Phosphatase) and MCP domains, which are signalling domains that interact with protein partners to relay a signal. MCPs are part of a transmembrane protein complex that controls bacterial chemotaxis. HK receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. In the case of HKs, signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses.
Pssm-ID: 350338 Cd Length: 139 Bit Score: 44.44 E-value: 2.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 63 NYLIGETMARMTSLSIAIDRPvDIKKMQSILEKTFDSEPRFSGLYFLNAKG----------------DVTASTTELKTKV 126
Cdd:cd12913 5 AESIAEQLASTLESLVSSGSL-DRELLENLLKQVLESNPDILGVYVAFEPNafsdetgrfapywyrdDGGIIDLDEPPDY 83
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1119636319 127 NLADRSFFTKAKETKKTVISDSYSSRI-TGQPIFTICVPVLD 167
Cdd:cd12913 84 DYRTRDWYKLAKETGKPVWTEPYIDEVgTGVLMITISVPIYD 125
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
425-501 |
7.96e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 42.62 E-value: 7.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 425 LTISLGALDKKAIIKVVDNGEGISQEMLDHIFlpfvtskEKGT---------GLGLVVCKRIVLMYGGSIHIESEVRRGT 495
Cdd:cd16954 57 VEVTARQTDGGLHLIVDDDGPGVPESQRSKIF-------QRGQrldeqrpgqGLGLAIAKEIVEQYGGELSLSDSPLGGA 129
|
....*.
gi 1119636319 496 EVTITL 501
Cdd:cd16954 130 RFEVVF 135
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
301-505 |
9.47e-05 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 45.31 E-value: 9.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 301 HEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIEQEIKRINQIVSEFLVLGKPTAEKWELNS--------LQDIIGEIMP 372
Cdd:PRK10618 459 DELKQPLQSLAQLAAQLRQTSDEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQDWKPEQelfslqdlIDEVLPEVLP 538
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 373 IIYSEG----NLYNVEVELQYLTEQPLLVKctkdhIKQVILNVAKngleSMPEGGKLTISLgALDKKA----IIKVVDNG 444
Cdd:PRK10618 539 AIKRKGlqllIHNHLKAEQLRIGDRDALRK-----ILLLLLNYAI----TTTAYGKITLEV-DQDESSpdrlTIRILDTG 608
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1119636319 445 EGISQEMLDHIFLPFVTSKE-----KGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSA 505
Cdd:PRK10618 609 AGVSIKELDNLHFPFLNQTQgdrygKASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLKMLA 674
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
407-502 |
2.58e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 40.45 E-value: 2.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 407 VILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFV----TSKEKGTGLGLVVCKRIVLMYG 482
Cdd:cd16923 4 VFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYrgdnSRNTEGAGLGLSIAKAIIELHG 83
|
90 100
....*....|....*....|
gi 1119636319 483 GSIHIESEvRRGTEVTITLP 502
Cdd:cd16923 84 GSASAEYD-DNHDLFKVRLP 102
|
|
| PRK10547 |
PRK10547 |
chemotaxis protein CheA; Provisional |
382-504 |
2.28e-03 |
|
chemotaxis protein CheA; Provisional
Pssm-ID: 236712 [Multi-domain] Cd Length: 670 Bit Score: 40.48 E-value: 2.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 382 NVEVELQYL---TE----------QPL--LVKCTKDHikqvilnvaknGLES--------MPEGGKLTISLGALDKKAII 438
Cdd:PRK10547 364 GKQVELTLVgssTEldkslieriiDPLthLVRNSLDH-----------GIELpekrlaagKNSVGNLILSAEHQGGNICI 432
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 439 KVVDNGEG----------------ISQEMLDH-----IFLPFVTSKEK-----GTGLGLVVCKRIVLMYGGSIHIESEVR 492
Cdd:PRK10547 433 EVTDDGAGlnrerilakaasqglaVSENMSDEevgmlIFAPGFSTAEQvtdvsGRGVGMDVVKRNIQEMGGHVEIQSKQG 512
|
170
....*....|..
gi 1119636319 493 RGTEVTITLPVS 504
Cdd:PRK10547 513 KGTTIRILLPLT 524
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
407-502 |
5.07e-03 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 39.43 E-value: 5.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119636319 407 VILNVAKNGLES---MPEGGK-LTISLGALDKKAIIKVVDNGEGISQEMLDHIFLPFVTSK--EKGT-GLGLVVCKRIVL 479
Cdd:PRK15053 436 IVGNLLDNAFEAslrSDEGNKiVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGVSTRadEPGEhGIGLYLIASYVT 515
|
90 100
....*....|....*....|...
gi 1119636319 480 MYGGSIHIESEVRRGTEVTITLP 502
Cdd:PRK15053 516 RCGGVITLEDNDPCGTLFSIFIP 538
|
|
| HATPase_MutL-MLH-PMS-like |
cd16926 |
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ... |
438-463 |
9.12e-03 |
|
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.
Pssm-ID: 340403 [Multi-domain] Cd Length: 188 Bit Score: 37.42 E-value: 9.12e-03
10 20
....*....|....*....|....*.
gi 1119636319 438 IKVVDNGEGISQEMLDHIFLPFVTSK 463
Cdd:cd16926 45 IRVTDNGSGISREDLELAFERHATSK 70
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