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Conserved domains on  [gi|1151112977|ref|WP_078085269|]
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sensor histidine kinase [Microbulbifer mangrovi]

Protein Classification

sensor histidine kinase( domain architecture ID 11461692)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to an external signal

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0004673|GO:0007165|GO:0000155
PubMed:  10637609|10339418
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
20-362 3.76e-82

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


:

Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 254.02  E-value: 3.76e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977  20 YRALQWSGWAGYTLLTFIGGFFWVESHWLYTGYIAVATASGIAISEGMRRGFQRLWNQQPAQRLLGTLGVIVVGAALWAA 99
Cdd:COG3275    14 LLLLLLLLLSLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 100 IKFGGSLWLYGRESDEHPVVLAVYWFSYSFLIYMTWTALYYGIKYYQASLLQQEKALKAESIAHQSQLKMLRYQLNPHFL 179
Cdd:COG3275    94 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFL 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 180 FNTLNAISTLILEqDGKTANSMVTRLSQFLRHSLDNDPMQKVTLAKEVEALMLYLDIEKVRFADRLQVNVDLDGEAPEAL 259
Cdd:COG3275   174 FNTLNSIYSLIRE-DPEKARELLLKLSDLLRYSLYESDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 260 VPSLLLQPIVENAIKYGISQREWGGQITIKARVFAGELLLEISDNGPGVPEaelARLGSGSGVGIRNTCERLQALYGVEQ 339
Cdd:COG3275   253 IPPLLLQPLVENAIKHGISSKEGGGTISISIEVEGDRLVIEVENNGVGIQP---KKKKKGSGIGLKNVRERLELLYGDKY 329

                         330       340
                  ....*....|....*....|...
gi 1151112977 340 KTRFCNRPEGGLAVHLRIPFERD 362
Cdd:COG3275   330 SLEIESTDGGGTKVTLKIPLKKE 352
 
Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
20-362 3.76e-82

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 254.02  E-value: 3.76e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977  20 YRALQWSGWAGYTLLTFIGGFFWVESHWLYTGYIAVATASGIAISEGMRRGFQRLWNQQPAQRLLGTLGVIVVGAALWAA 99
Cdd:COG3275    14 LLLLLLLLLSLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 100 IKFGGSLWLYGRESDEHPVVLAVYWFSYSFLIYMTWTALYYGIKYYQASLLQQEKALKAESIAHQSQLKMLRYQLNPHFL 179
Cdd:COG3275    94 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFL 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 180 FNTLNAISTLILEqDGKTANSMVTRLSQFLRHSLDNDPMQKVTLAKEVEALMLYLDIEKVRFADRLQVNVDLDGEAPEAL 259
Cdd:COG3275   174 FNTLNSIYSLIRE-DPEKARELLLKLSDLLRYSLYESDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 260 VPSLLLQPIVENAIKYGISQREWGGQITIKARVFAGELLLEISDNGPGVPEaelARLGSGSGVGIRNTCERLQALYGVEQ 339
Cdd:COG3275   253 IPPLLLQPLVENAIKHGISSKEGGGTISISIEVEGDRLVIEVENNGVGIQP---KKKKKGSGIGLKNVRERLELLYGDKY 329

                         330       340
                  ....*....|....*....|...
gi 1151112977 340 KTRFCNRPEGGLAVHLRIPFERD 362
Cdd:COG3275   330 SLEIESTDGGGTKVTLKIPLKKE 352
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 165-245 3.94e-30

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 110.22  E-value: 3.94e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 165 SQLKMLRYQLNPHFLFNTLNAISTLILEQDgKTANSMVTRLSQFLRHSLDNDpMQKVTLAKEVEALMLYLDIEKVRFADR 244
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDP-EEAAEMILKLSDLLRYSLYEG-EELVTLEEELEFLENYLEIQKIRFGDR 78


                  .
gi 1151112977 245 L 245
Cdd:pfam06580  79 L 79
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 260-358 5.30e-20

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 83.64  E-value: 5.30e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 260 VPSLLLQPIVENAIKYGISQREWGGQITIKARVFAGELLLEISDNGPGVPEAELARLGSGS--GVGIRNTCERLQALYGV 337
Cdd:cd16956     1 LPFLTLQPIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMDPDTLARILIRSsnGLGLNLVDKRLRQAFGN 80

                          90       100
                  ....*....|....*....|.
gi 1151112977 338 EQKTRFCNRPEGGLAVHLRIP 358
Cdd:cd16956    81 DYGLDIECAPGEGTRITIRLP 101
PRK10337 PRK10337
sensor protein QseC; Provisional
 212-356 2.01e-12

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 67.75  E-value: 2.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 212 SLDN-DPMQKVTLAKEVEALMlyldIEKVRFADRLQVNVDLDGEAP------EALVPSLLLQPIVENAIKYgiSQRewGG 284
Cdd:PRK10337  301 SLDNlQDVAEIPLEDLLQSAV----MDIYHTAQQAGIDVRLTLNAHpvirtgQPLLLSLLVRNLLDNAIRY--SPQ--GS 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 285 Q--ITIKARVFagelllEISDNGPGVPEAELARLG-----------SGSGVGIrNTCERLQALYGVeqKTRFCNRPEGGL 351
Cdd:PRK10337  373 VvdVTLNARNF------TVRDNGPGVTPEALARIGerfyrppgqeaTGSGLGL-SIVRRIAKLHGM--NVSFGNAPEGGF 443


                  ....*
gi 1151112977 352 AVHLR 356
Cdd:PRK10337  444 EAKVS 448
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 264-360 1.47e-11

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 60.74  E-value: 1.47e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977  264 LLQPIVENAIKYGISqrewGGQITIKARVFAGELLLEISDNGPGVPEAELARL-------------GSGSGVG---IRNT 327
Cdd:smart00387   9 VLSNLLDNAIKYTPE----GGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIfepffrtdkrsrkIGGTGLGlsiVKKL 84

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1151112977  328 CERLQALYGVEqktrfcNRPEGGLAVHLRIPFE 360
Cdd:smart00387  85 VELHGGEISVE------SEPGGGTTFTITLPLE 111
 
Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
20-362 3.76e-82

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 254.02  E-value: 3.76e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977  20 YRALQWSGWAGYTLLTFIGGFFWVESHWLYTGYIAVATASGIAISEGMRRGFQRLWNQQPAQRLLGTLGVIVVGAALWAA 99
Cdd:COG3275    14 LLLLLLLLLSLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 100 IKFGGSLWLYGRESDEHPVVLAVYWFSYSFLIYMTWTALYYGIKYYQASLLQQEKALKAESIAHQSQLKMLRYQLNPHFL 179
Cdd:COG3275    94 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFL 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 180 FNTLNAISTLILEqDGKTANSMVTRLSQFLRHSLDNDPMQKVTLAKEVEALMLYLDIEKVRFADRLQVNVDLDGEAPEAL 259
Cdd:COG3275   174 FNTLNSIYSLIRE-DPEKARELLLKLSDLLRYSLYESDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 260 VPSLLLQPIVENAIKYGISQREWGGQITIKARVFAGELLLEISDNGPGVPEaelARLGSGSGVGIRNTCERLQALYGVEQ 339
Cdd:COG3275   253 IPPLLLQPLVENAIKHGISSKEGGGTISISIEVEGDRLVIEVENNGVGIQP---KKKKKGSGIGLKNVRERLELLYGDKY 329

                         330       340
                  ....*....|....*....|...
gi 1151112977 340 KTRFCNRPEGGLAVHLRIPFERD 362
Cdd:COG3275   330 SLEIESTDGGGTKVTLKIPLKKE 352
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
129-362 5.84e-72

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 230.67  E-value: 5.84e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 129 FLIYMTWTALYYGIKYYQASLLQQEKALKaesiahQSQLKMLRYQLNPHFLFNTLNAISTLILEQDGKTANSMVTRLSQF 208
Cdd:COG2972   212 GILARSFNEMVERIKELIEEVYELELEKK------EAELKALQAQINPHFLFNTLNSIRWLAELEDPEEAEEMLEALSKL 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 209 LRHSLDNDPmQKVTLAKEVEALMLYLDIEKVRFADRLQVNVDLDGEAPEALVPSLLLQPIVENAIKYGISQREWGGQITI 288
Cdd:COG2972   286 LRYSLSKGD-ELVTLEEELELIKSYLEIQKLRFGDRLEVEIEIDEELLDLLIPKLILQPLVENAIEHGIEPKEGGGTIRI 364

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 289 KARVFAGELLLEISDNGPGVPEAELARL-------GSGSGVGIRNTCERLQALYGVEQKTRFCNRPEGGLAVHLRIPFER 361
Cdd:COG2972   365 SIRKEGDRLVITVEDNGVGMPEEKLEKLleelsskGEGRGIGLRNVRERLKLYYGEEYGLEIESEPGEGTTVTIRIPLEE 444


                  .
gi 1151112977 362 D 362
Cdd:COG2972   445 E 445
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 165-245 3.94e-30

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 110.22  E-value: 3.94e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 165 SQLKMLRYQLNPHFLFNTLNAISTLILEQDgKTANSMVTRLSQFLRHSLDNDpMQKVTLAKEVEALMLYLDIEKVRFADR 244
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDP-EEAAEMILKLSDLLRYSLYEG-EELVTLEEELEFLENYLEIQKIRFGDR 78


                  .
gi 1151112977 245 L 245
Cdd:pfam06580  79 L 79
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 260-358 5.30e-20

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 83.64  E-value: 5.30e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 260 VPSLLLQPIVENAIKYGISQREWGGQITIKARVFAGELLLEISDNGPGVPEAELARLGSGS--GVGIRNTCERLQALYGV 337
Cdd:cd16956     1 LPFLTLQPIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMDPDTLARILIRSsnGLGLNLVDKRLRQAFGN 80

                          90       100
                  ....*....|....*....|.
gi 1151112977 338 EQKTRFCNRPEGGLAVHLRIP 358
Cdd:cd16956    81 DYGLDIECAPGEGTRITIRLP 101
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 260-358 3.82e-19

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 81.72  E-value: 3.82e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 260 VPSLLLQPIVENAIKYGISQREWGGQITIKARVFAGELLLEISDNGPGVPEAELARLGS----GSGVGIRNTCERLQALY 335
Cdd:cd16924     1 IPPFTLQPLVENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGIDPKVLNILGKkpkeGNGIGLYNVHQRLILLF 80

                          90       100
                  ....*....|....*....|...
gi 1151112977 336 GVEQKTRFCNRPEGGLAVHLRIP 358
Cdd:cd16924    81 GEDYGIHIASEPDKGTRITFTIP 103
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 260-358 1.10e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 72.07  E-value: 1.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 260 VPSLLLQPIVENAIKYGISQREWGGQITIKARVFAGELLLEISDNGPGVPEAELARLG-------SGSGVGIRNTCERLQ 332
Cdd:cd16957     1 VPPFALQVLVENAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGkttvtseKGTGTALENLNRRLI 80

                          90       100
                  ....*....|....*....|....*.
gi 1151112977 333 ALYGVEQKTRFCNRPEGGLAVHLRIP 358
Cdd:cd16957    81 GLFGSEACLHIESEVHGGTEVWFVIP 106
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
146-358 2.99e-15

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 74.17  E-value: 2.99e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 146 QASLLQQEKALKAE---SIAHQsqlkmLRyqlNPhflfntLNAISTLI--LEQDGKTANSMVTRLSQFLRHSLDNdpMQK 220
Cdd:COG2205     5 ALEELEELERLKSEflaNVSHE-----LR---TP------LTSILGAAelLLDEEDLSPEERRELLEIIRESAER--LLR 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 221 -----VTLAKeVEALMLYLDIEKVRFAD----------------RLQVNVDLDGEAPEALVPSLLLQPIV----ENAIKY 275
Cdd:COG2205    69 liedlLDLSR-LESGKLSLELEPVDLAElleeaveelrplaeekGIRLELDLPPELPLVYADPELLEQVLanllDNAIKY 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 276 GISqrewGGQITIKARVFAGELLLEISDNGPGVPEAELARL------------GSGSGVG---IRNTCERLQALYGVEqk 340
Cdd:COG2205   148 SPP----GGTITISARREGDGVRISVSDNGPGIPEEELERIferfyrgdnsrgEGGTGLGlaiVKRIVEAHGGTIWVE-- 221

                         250
                  ....*....|....*...
gi 1151112977 341 trfcNRPEGGLAVHLRIP 358
Cdd:COG2205   222 ----SEPGGGTTFTVTLP 235
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 260-358 4.47e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 70.18  E-value: 4.47e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 260 VPSLLLQPIVENAIKYGISQREWGGQITIKARVFAG-ELLLEISDNGPGVPEAELARL----GSGSGVGIRNTCERLQAL 334
Cdd:cd16955     1 IPKLMIQPLVENAIVHGIQEKKGKGVVKISVKKQLKnRLHIAVEDNGIGISPKVIERVeqdeMPGNKIGLLNVHQRLKLG 80

                          90       100
                  ....*....|....*....|....
gi 1151112977 335 YGVEQKTRfcNRPEGGLAVHLRIP 358
Cdd:cd16955    81 YGEGLHIR--SRPDPGTLIAFYIP 102
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
53-360 5.63e-15

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 74.94  E-value: 5.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977  53 IAVATASGIAISEGMRRGFQRLWNQQPAQRLLGTLGVIVVGAALWAAIKFGGSLWLYGRESDEHPVVLAVYWFSYSFLIY 132
Cdd:COG0642     6 LLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 133 MTWTALYYGIKYYQASLLQQEKALKAE---SIAHQsqlkmLRyqlNPhflfntLNAISTLI-----------------LE 192
Cdd:COG0642    86 LLLLLLLLLLLLALLLLLEEANEAKSRflaNVSHE-----LR---TP------LTAIRGYLellleeldeeqreyletIL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 193 QDGKTANSMVTRLSQFLR--HSLDNDPMQKVTLAKEVEALMLylDIEKVRFADRLQVNVDLDGEAPEALVPSLLLQPI-- 268
Cdd:COG0642   152 RSADRLLRLINDLLDLSRleAGKLELEPEPVDLAELLEEVVE--LFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVll 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 269 --VENAIKYGISqrewGGQITIKARVFAGELLLEISDNGPGVPEAELARL------------GSGSGVG---IRNTCERL 331
Cdd:COG0642   230 nlLSNAIKYTPE----GGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIfepffrtdpsrrGGGTGLGlaiVKRIVELH 305

                         330       340
                  ....*....|....*....|....*....
gi 1151112977 332 QALYGVEqktrfcNRPEGGLAVHLRIPFE 360
Cdd:COG0642   306 GGTIEVE------SEPGKGTTFTVTLPLA 328
PRK10337 PRK10337
sensor protein QseC; Provisional
 212-356 2.01e-12

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 67.75  E-value: 2.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 212 SLDN-DPMQKVTLAKEVEALMlyldIEKVRFADRLQVNVDLDGEAP------EALVPSLLLQPIVENAIKYgiSQRewGG 284
Cdd:PRK10337  301 SLDNlQDVAEIPLEDLLQSAV----MDIYHTAQQAGIDVRLTLNAHpvirtgQPLLLSLLVRNLLDNAIRY--SPQ--GS 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 285 Q--ITIKARVFagelllEISDNGPGVPEAELARLG-----------SGSGVGIrNTCERLQALYGVeqKTRFCNRPEGGL 351
Cdd:PRK10337  373 VvdVTLNARNF------TVRDNGPGVTPEALARIGerfyrppgqeaTGSGLGL-SIVRRIAKLHGM--NVSFGNAPEGGF 443


                  ....*
gi 1151112977 352 AVHLR 356
Cdd:PRK10337  444 EAKVS 448
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 264-360 1.47e-11

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 60.74  E-value: 1.47e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977  264 LLQPIVENAIKYGISqrewGGQITIKARVFAGELLLEISDNGPGVPEAELARL-------------GSGSGVG---IRNT 327
Cdd:smart00387   9 VLSNLLDNAIKYTPE----GGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIfepffrtdkrsrkIGGTGLGlsiVKKL 84

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1151112977  328 CERLQALYGVEqktrfcNRPEGGLAVHLRIPFE 360
Cdd:smart00387  85 VELHGGEISVE------SEPGGGTTFTITLPLE 111
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 264-361 1.96e-11

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 60.07  E-value: 1.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 264 LLQPIVENAIKYGISqrewGGQITIKARVfAGELLLEISDNGPGVPEAELARL-----------GSGSGVGIRNtCERLQ 332
Cdd:pfam02518   9 VLSNLLDNALKHAAK----AGEITVTLSE-GGELTLTVEDNGIGIPPEDLPRIfepfstadkrgGGGTGLGLSI-VRKLV 82

                          90       100
                  ....*....|....*....|....*....
gi 1151112977 333 ALYGVEqkTRFCNRPEGGLAVHLRIPFER 361
Cdd:pfam02518  83 ELLGGT--ITVESEPGGGTTVTLTLPLAQ 109
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 149-362 2.31e-11

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 64.60  E-value: 2.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 149 LLQQEK--ALK--AESIAH---------QSQLKMLRYQLNPHFLFN--TLNAISTLILEQdGKTANSMVTRLSQFLR-HS 212
Cdd:COG5000   192 LLRAERlaAWGelARRIAHeiknpltpiQLSAERLRRKLADKLEEDreDLERALDTIIRQ-VDRLKRIVDEFLDFARlPE 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 213 LDNDPMQKVTLAKEVEALMlyldiEKVRFADRLQVNVDLDGEAPEALV-PSLLLQPI---VENAIkYGISQrewGGQITI 288
Cdd:COG5000   271 PQLEPVDLNELLREVLALY-----EPALKEKDIRLELDLDPDLPEVLAdRDQLEQVLinlLKNAI-EAIEE---GGEIEV 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 289 KARVFAGELLLEISDNGPGVPEAELARL--------GSGSGVG---IRNTCERLQALYGVEqktrfcNRPEGGLAVHLRI 357
Cdd:COG5000   342 STRREDGRVRIEVSDNGPGIPEEVLERIfepffttkPKGTGLGlaiVKKIVEEHGGTIELE------SRPGGGTTFTIRL 415


                  ....*
gi 1151112977 358 PFERD 362
Cdd:COG5000   416 PLAEE 420
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 146-358 3.21e-11

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 64.05  E-value: 3.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 146 QASLLQQEK--ALK--AESIAHQ---------SQLKMLRYQLNPHFLFNTLNAISTLILEQdGKTANSMVTRLSQFLRhs 212
Cdd:COG4191   130 QEQLVQSEKlaALGelAAGIAHEinnplaailGNAELLRRRLEDEPDPEELREALERILEG-AERAAEIVRSLRAFSR-- 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 213 LDNDPMQKVTLAKEVEALmlyLDIEKVRF-ADRLQVNVDLDGEAPEALV-PSLLLQ---PIVENAIkYGISQREwGGQIT 287
Cdd:COG4191   207 RDEEEREPVDLNELIDEA---LELLRPRLkARGIEVELDLPPDLPPVLGdPGQLEQvllNLLINAI-DAMEEGE-GGRIT 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 288 IKARVFAGELLLEISDNGPGVPEAELARL----------GSGSGVGirntcerlqaL---YG-VEQ---KTRFCNRPEGG 350
Cdd:COG4191   282 ISTRREGDYVVISVRDNGPGIPPEVLERIfepffttkpvGKGTGLG----------LsisYGiVEKhggRIEVESEPGGG 351


                  ....*...
gi 1151112977 351 LAVHLRIP 358
Cdd:COG4191   352 TTFTITLP 359
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 181-362 8.01e-11

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 62.94  E-value: 8.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 181 NTLNAISTLILEQDGKTANSMVTRLSQfLRHSLDNDPMQKVTLAkEVEALMLYldieKVRFADRLQVNVDLDgeaPEALV 260
Cdd:COG3290   202 NHLHTISGLLQLGEYDEALEYIDEISE-ELQELIDSLLSRIGNP-VLAALLLG----KAARARERGIDLTID---IDSDL 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 261 PSLLLQP---------IVENAIKYGISQREWGGQITIKARVFAGELLLEISDNGPGVPEAELARL---------GSGSGV 322
Cdd:COG3290   273 PDLPLSDtdlvtilgnLLDNAIEAVEKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIfergfstklGEGRGL 352

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1151112977 323 G---IRNTCERlqalYG--VEqktrFCNRPEGGLAVHLRIPFERD 362
Cdd:COG3290   353 GlalVKQIVEK----YGgtIE----VESEEGEGTVFTVRLPKEGE 389
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
218-362 1.93e-10

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 61.49  E-value: 1.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 218 MQKVTLAKEVEALMLYLDIEkvrfADRLQVNVDLDGEAPEALV---PSLLLQPI---VENAIKYGisqrEWGGQITIKAR 291
Cdd:COG5002   237 KEPVDLAELLEEVVEELRPL----AEEKGIELELDLPEDPLLVlgdPDRLEQVLtnlLDNAIKYT----PEGGTITVSLR 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 292 VFAGELLLEISDNGPGVPEAELARL--------------GSGSGVG--I-RNTCERLQALYGVEqktrfcNRPEGGLAVH 354
Cdd:COG5002   309 EEDDQVRISVRDTGIGIPEEDLPRIferfyrvdksrsreTGGTGLGlaIvKHIVEAHGGRIWVE------SEPGKGTTFT 382


                  ....*...
gi 1151112977 355 LRIPFERD 362
Cdd:COG5002   383 ITLPLARE 390
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 264-358 1.01e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 52.47  E-value: 1.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 264 LLQPIVENAIKYgisqREWGGQITIKARVFAGELLLEISDNGPGVPEAELARLGS--------------GSGVGIRNTCE 329
Cdd:cd16946     8 LFVNLLENSLRY----TDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFErfyrvessrnrasgGSGLGLAICHN 83

                          90       100
                  ....*....|....*....|....*....
gi 1151112977 330 RLQALYGveqKTRFCNRPEGGLAVHLRIP 358
Cdd:cd16946    84 IALAHGG---TISAEHSPLGGLRLVLTLP 109
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 218-361 2.87e-08

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 55.30  E-value: 2.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 218 MQKVTLAKEVEALMLYLdiekVRFADRLQVNVDLDGEA----PEALVP-SLLLQPIVENAIKYGISQREwGGQITIKARV 292
Cdd:COG3920   356 WEGVDLRDYLRELLEPL----RDSYGGRGIRIELDGPDvelpADAAVPlGLILNELVTNALKHAFLSGE-GGRIRVSWRR 430

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1151112977 293 FAGELLLEISDNGPGVPEAelARLGSGSGVG---IRNTCERLQAlygveqktRFCNRPEGGLAVHLRIPFER 361
Cdd:COG3920   431 EDGRLRLTVSDNGVGLPED--VDPPARKGLGlrlIRALVRQLGG--------TLELDRPEGTRVRITFPLAE 492
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
73-323 3.74e-08

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 54.47  E-value: 3.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977  73 RLWNQQpAQRLLGTLGVIVVG--------------AALWAAIKFGGSLW-----LYGRESDEHPVVLAVYWFS-----YS 128
Cdd:COG3852    30 TYVNPA-AERLLGLSAEELLGrplaelfpedsplrELLERALAEGQPVTerevtLRRKDGEERPVDVSVSPLRdaegeGG 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 129 FLIYMT-WTALyygiKYYQASLLQQEK--ALK--AESIAHQ-----------SQLkmLRYQLNPhflfNTLNAISTLILE 192
Cdd:COG3852   109 VLLVLRdITER----KRLERELRRAEKlaAVGelAAGLAHEirnpltgirgaAQL--LERELPD----DELREYTQLIIE 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 193 QdGKTANSMVTRLSQFLRHSLDNdpMQKV---TLAKEVEALMlyldieKVRFADRLQVNVDLDGEAPEALV-PSLLLQP- 267
Cdd:COG3852   179 E-ADRLNNLVDRLLSFSRPRPPE--REPVnlhEVLERVLELL------RAEAPKNIRIVRDYDPSLPEVLGdPDQLIQVl 249

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1151112977 268 --IVENAIKYGISqrewGGQITIKARV----------FAGELLLEISDNGPGVPEAELARL--------GSGSGVG 323
Cdd:COG3852   250 lnLVRNAAEAMPE----GGTITIRTRVerqvtlgglrPRLYVRIEVIDNGPGIPEEILDRIfepffttkEKGTGLG 321
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
160-362 5.53e-08

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 53.08  E-value: 5.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 160 SIAHQSQLKMLRYQLNPHFLFNTLNAISTLIleqdgKTANSMVTRLSqflrHSLDNDPMQKVTLAKEVEALmlyldIEKV 239
Cdd:COG4585    71 AIKLQLEAARRLLDADPEAAREELEEIRELA-----REALAELRRLV----RGLRPPALDDLGLAAALEEL-----AERL 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 240 RFADRLQVNVDLDGEA---PEALVPSLL--LQPIVENAIKYgiSQrewGGQITIKARVFAGELLLEISDNGPGVPEAELA 314
Cdd:COG4585   137 LRAAGIRVELDVDGDPdrlPPEVELALYriVQEALTNALKH--AG---ATRVTVTLEVDDGELTLTVRDDGVGFDPEAAP 211

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1151112977 315 rlgsGSGVGIRNTCERLQALYGveqKTRFCNRPEGGLAVHLRIPFERD 362
Cdd:COG4585   212 ----GGGLGLRGMRERAEALGG---TLTIGSAPGGGTRVRATLPLAAA 252
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 262-356 1.08e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 49.71  E-value: 1.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 262 SLLLQPIVENAIKYGISqrewGGQITIKARVFAGELLLeISDNGPGVPEAELARLGS-----------GSGVGIrNTCER 330
Cdd:cd16940    15 FLLLRNLVDNAVRYSPQ----GSRVEIKLSADDGAVIR-VEDNGPGIDEEELEALFErfyrsdgqnygGSGLGL-SIVKR 88

                          90       100
                  ....*....|....*....|....*.
gi 1151112977 331 LQALYGVeqKTRFCNRPEGGLAVHLR 356
Cdd:cd16940    89 IVELHGG--QIFLGNAQGGGLEAWVR 112
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 265-358 1.84e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 48.86  E-value: 1.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 265 LQPIVENAIKYGisqrewGGQITIKARVFAGELLLEISDNGPGVPEAELARL--------------GSGSGVGIRNTCER 330
Cdd:cd16949     5 LENVLRNALRYS------PSKILLDISQDGDQWTITITDDGPGVPEDQLEQIflpfyrvdsardreSGGTGLGLAIAERA 78

                          90       100
                  ....*....|....*....|....*...
gi 1151112977 331 LQALYGveqKTRFCNRPEGGLAVHLRIP 358
Cdd:cd16949    79 IEQHGG---KIKASNRKPGGLRVRIWLP 103
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 203-358 4.37e-07

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 51.38  E-value: 4.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 203 TRLSQflRHSLDndPMQKVTLAKEVEALMLYLDIEkvrfADRLQVNVDLDGEAPEALVPSLLLQP----IVENAIKYGIS 278
Cdd:PRK11100  315 ARLEQ--RQELE--VLEPVALAALLEELVEAREAQ----AAAKGITLRLRPDDARVLGDPFLLRQalgnLLDNAIDFSPE 386

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 279 qrewGGQITIKARVFAGELLLEISDNGPGVPEAELARLG-------------SGSGVGIrNTCERLQALYGVEqkTRFCN 345
Cdd:PRK11100  387 ----GGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFerfyslprpangrKSTGLGL-AFVREVARLHGGE--VTLRN 459

                         170
                  ....*....|...
gi 1151112977 346 RPEGGLAVHLRIP 358
Cdd:PRK11100  460 RPEGGVLATLTLP 472
PRK10490 PRK10490
sensor protein KdpD; Provisional
 246-360 5.15e-07

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 51.58  E-value: 5.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 246 QVNVDLDGEAPEALVPSLLLQPI----VENAIKYGISQrewgGQITIKARVFAGELLLEISDNGPGVPEAELARL----- 316
Cdd:PRK10490  760 PINLSLPEPLTLIHVDGPLFERVlinlLENAVKYAGAQ----AEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIfdkfa 835

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1151112977 317 ---------GSGSGVGIrntCERLQALYGveQKTRFCNRPEGGLAVHLRIPFE 360
Cdd:PRK10490  836 rgnkesaipGVGLGLAI---CRAIVEVHG--GTIWAENRPEGGACFRVTLPLE 883
envZ PRK09467
osmolarity sensor protein; Provisional
 269-361 5.57e-07

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 51.06  E-value: 5.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 269 VENAIKYGisqrewGGQITIKARVFAGELLLEISDNGPGVPEAELARL------------GSGSGVG---IRNTCERLQA 333
Cdd:PRK09467  340 VVNAARYG------NGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLfqpftrgdsargSSGTGLGlaiVKRIVDQHNG 413

                          90       100
                  ....*....|....*....|....*...
gi 1151112977 334 lygveqKTRFCNRPEGGLAVHLRIPFER 361
Cdd:PRK09467  414 ------KVELGNSEEGGLSARAWLPLTT 435
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 199-323 3.91e-06

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 48.63  E-value: 3.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 199 NSMVTRLSQFLRHSLDNDPMQKV---TLAKEVEAlMLYLDIE----KVRFADRLQVNVDldgeaPEALVpsLLLQPIVEN 271
Cdd:COG4251   334 QALIDDLLAYSRVGRQELEFEPVdlnELLEEVLE-DLEPRIEergaEIEVGPLPTVRGD-----PTLLR--QVFQNLISN 405

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1151112977 272 AIKYGISQREwgGQITIKARVFAGELLLEISDNGPGVPEAELARL------------GSGSGVG 323
Cdd:COG4251   406 AIKYSRPGEP--PRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIfeifqrlhsrdeYEGTGIG 467
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
235-324 4.01e-06

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 45.67  E-value: 4.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 235 DIEKVR-FADRLQVNVDLDGEAPEALVpsLLLQPIVENAIKYGiSQREWGGQITIKARVFAGELLLEISDNGPGVPEAEL 313
Cdd:COG2172    10 DLGLARrAVRALLRELGLDEDDADDLV--LAVSEAVTNAVRHA-YGGDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDL 86

                          90
                  ....*....|....
gi 1151112977 314 AR---LGSGSGVGI 324
Cdd:COG2172    87 PDpysTLAEGGRGL 100
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 264-358 5.12e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 44.75  E-value: 5.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 264 LLQPIVENAIKYGisqrewGGQITIKARVFAGELLLEISDNGPGVPEAEL------------ARLGSGSGVGIRnTCERL 331
Cdd:cd16950     4 VLSNLVDNALRYG------GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVdelfqpfyrgdnARGTSGTGLGLA-IVQRI 76

                          90       100
                  ....*....|....*....|....*..
gi 1151112977 332 QALYGveQKTRFCNRPEGGLAVHLRIP 358
Cdd:cd16950    77 SDAHG--GSLTLANRAGGGLCARIELP 101
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 271-358 1.46e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 42.93  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 271 NAIKYgiSQrewGGQITIKARVFAGELLLEISDNGPGvPEAELARLGSGSG-VGIRntcERLQALYGVeqkTRFCNRPEG 349
Cdd:cd16917    11 NALKH--AG---ASRVRVTLSYTADELTLTVVDDGVG-FDGPAPPGGGGFGlLGMR---ERAELLGGT---LTIGSRPGG 78


                  ....*....
gi 1151112977 350 GLAVHLRIP 358
Cdd:cd16917    79 GTRVTARLP 87
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 237-323 1.90e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 43.77  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 237 EKVRFADRLQVNVDLDGEA-----PEALVPslLLQPIVENAIKYGISQrewggqITIKARVFAGELLLEISDNGPGVPEA 311
Cdd:cd16954    11 NKVYQRKGVSISLDISPELrfpgeRNDLME--LLGNLLDNACKWCLEF------VEVTARQTDGGLHLIVDDDGPGVPES 82

                          90       100
                  ....*....|....*....|..
gi 1151112977 312 ELARLG----------SGSGVG 323
Cdd:cd16954    83 QRSKIFqrgqrldeqrPGQGLG 104
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 268-358 3.85e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 42.27  E-value: 3.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 268 IVENAIKYGISQREWGGQITIKARVFAGELLLEISDNGPGVPEAELARL---------GSGSGVG---IRNTCERLQALY 335
Cdd:cd16915     8 LIDNALDALAATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVfergvstkgQGERGIGlalVRQSVERLGGSI 87

                          90       100
                  ....*....|....*....|...
gi 1151112977 336 GVEqktrfcNRPEGGLAVHLRIP 358
Cdd:cd16915    88 TVE------SEPGGGTTFSIRIP 104
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 269-362 4.01e-05

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 45.29  E-value: 4.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 269 VENAIKyGISQREwGGQITIKARVFAGELLLEISDNGPGVPEAELARL--------GSGSGVGIRNTCERLQALYGveqK 340
Cdd:PRK11086  442 IENALE-AVGGEE-GGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIfdkgystkGSNRGVGLYLVKQSVENLGG---S 516

                          90       100
                  ....*....|....*....|..
gi 1151112977 341 TRFCNRPEGGLAVHLRIPFERD 362
Cdd:PRK11086  517 IAVESEPGVGTQFFVQIPWDGE 538
PRK09303 PRK09303
histidine kinase;
150-336 4.24e-05

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 44.94  E-value: 4.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 150 LQQEKALKAESIAHQSQ-LKMLRYQL-NPhfLFNTLNAISTLILEQDGKTANSMVTRLSQFLRH---------------- 211
Cdd:PRK09303  137 LRQENETLLEQLKFKDRvLAMLAHDLrTP--LTAASLALETLELGQIDEDTELKPALIEQLQDQarrqleeierlitdll 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 212 --------SLDNDPmQKVTLAK-EVEALmlyLDIEKVRFADRLQVNVDLDGEAPEALV-PSLLLQPIV---ENAIKYgis 278
Cdd:PRK09303  215 evgrtrweALRFNP-QKLDLGSlCQEVI---LELEKRWLAKSLEIQTDIPSDLPSVYAdQERIRQVLLnllDNAIKY--- 287

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1151112977 279 qREWGGQITI--------KARVfagelllEISDNGPGVPEAELARL------------GSGSGVGIrNTCERL-QALYG 336
Cdd:PRK09303  288 -TPEGGTITLsmlhrttqKVQV-------SICDTGPGIPEEEQERIfedrvrlprdegTEGYGIGL-SVCRRIvRVHYG 357
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 249-312 5.19e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 42.41  E-value: 5.19e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1151112977 249 VDLDGEAPEALvpSLLLQPIVENAIKYGISQREwGGQITIKARVFAGELLLEISDNGPGVPEAE 312
Cdd:cd16951    30 GPVSSEVATAI--GLVVNELLQNALKHAFSDRE-GGTITIRSVVDGDYLRITVIDDGVGLPQDE 90
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
199-358 5.57e-05

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 44.96  E-value: 5.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 199 NSMVTRLSQFLRHSLDNdpMQKVTLAKEV-EALMLYLDIEKvrfADRLQVNVDLDGEAPEALV-PSLL---LQPIVENAI 273
Cdd:PRK11360  439 NKVIDQLLEFSRPRESQ--WQPVSLNALVeEVLQLFQTAGV---QARVDFETELDNELPPIWAdPELLkqvLLNILINAV 513

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 274 KyGISQRewgGQITIKARVFA-GELLLEISDNGPGVPEAELARL--------GSGSGVGIRNTCERLQALYGVEQKTrfc 344
Cdd:PRK11360  514 Q-AISAR---GKIRIRTWQYSdGQVAVSIEDNGCGIDPELLKKIfdpffttkAKGTGLGLALSQRIINAHGGDIEVE--- 586

                         170
                  ....*....|....
gi 1151112977 345 NRPEGGLAVHLRIP 358
Cdd:PRK11360  587 SEPGVGTTFTLYLP 600
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 246-324 7.59e-05

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 44.34  E-value: 7.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 246 QVNVDLDGEAPEALV-PSLLLQPIVeNAIKYGISQREWGGQITIKARVFAGELLLEISDNGPGVPEAELARLG------- 317
Cdd:COG5805   377 QIRLELLDEDPFIYCdENQIKQVFI-NLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGepffttk 455


                  ....*...
gi 1151112977 318 -SGSGVGI 324
Cdd:COG5805   456 eKGTGLGL 463
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
240-362 1.84e-04

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 43.08  E-value: 1.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 240 RFADR-LQVNVDLDGEAPEALVPSLLLQ---PIVENAIKYGISqrewGGQITIKARVFAGELLLEISDNGPGVPEAELAR 315
Cdd:PRK10549  328 RFASRgLTLQLSLPDSATVFGDPDRLMQlfnNLLENSLRYTDS----GGSLHISAEQRDKTLRLTFADSAPGVSDEQLQK 403

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1151112977 316 L----------------GSGSGVGIrntCERLQALYGveQKTRFCNRPEGGLAVHLRIPFERD 362
Cdd:PRK10549  404 LferfyrtegsrnrasgGSGLGLAI---CLNIVEAHN--GRIIAAHSPFGGVSITVELPLERD 461
PRK11644 PRK11644
signal transduction histidine-protein kinase/phosphatase UhpB;
205-336 2.23e-04

signal transduction histidine-protein kinase/phosphatase UhpB;


Pssm-ID: 236945 [Multi-domain]  Cd Length: 495  Bit Score: 43.04  E-value: 2.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 205 LSQFLRHSLDNdpmqkVTLAKEVEALMLYLDIEKVRFADRLQVNVDlDGEAPEALVPSL--LLQPIVENAIKYGISQrew 282
Cdd:PRK11644  359 LGRLRPRQLDD-----LTLEQAIRSLMREMELEDRGIVSHLDWRID-ESALSETQRVTLfrVCQEGLNNIVKHADAS--- 429

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1151112977 283 ggQITIKARVFAGELLLEISDNGPGVPEAELARlgsgsGVGIRNTCERLQALYG 336
Cdd:PRK11644  430 --AVTLQGWQQDERLMLVIEDDGSGLPPGSGQQ-----GFGLRGMRERVTALGG 476
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 262-315 2.46e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 39.96  E-value: 2.46e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1151112977 262 SLLLQPIVENAIKYGisqrEWGGQITIKARVFAGELLLEISDNGPGVPEAELAR 315
Cdd:cd16948     7 SFIIGQIVSNALKYS----KQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPR 56
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 284-324 3.11e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 39.75  E-value: 3.11e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1151112977 284 GQITIKARVFAGELLLEISDNGPGVPEAELARL----------GSGSGVGI 324
Cdd:cd16976    22 PRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVfdpffttkpvGKGTGLGL 72
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
246-358 1.01e-03

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 40.72  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 246 QVNVDLDGEAPEALVP------SLLLQPIVENAIKYGISqrewGGQITIKARVFAGELLLEISDNGPGVPEAELARL--- 316
Cdd:PRK10755  227 QQTLLLPESAADITVQgdatllRLLLRNLVENAHRYSPE----GSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELska 302

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1151112977 317 -------GSGSGVGIrNTCERLQALYGveQKTRFCNRPE-GGLAVHLRIP 358
Cdd:PRK10755  303 fvrmdsrYGGIGLGL-SIVSRITQLHH--GQFFLQNRQErSGTRAWVWLP 349
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
261-313 1.13e-03

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 40.69  E-value: 1.13e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1151112977 261 PSLL---LQPIVENAIKYGISQrewggqITIKARVFAGELLLEISDNGPGVPEAEL 313
Cdd:PRK09470  351 PNALasaLENIVRNALRYSHTK------IEVAFSVDKDGLTITVDDDGPGVPEEER 400
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 261-352 1.62e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 37.83  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 261 PSLLLQPI---VENAIKYGISqrewGGQITIKARVFAGELLLEISDNGPGVPEAELARL----------GSG---SGVGI 324
Cdd:cd16945     2 PFLLRQAInnlLDNAIDFSPE----GGLIALQLEADTEGIELLVFDEGSGIPDYALNRVferfyslprpHSGqksTGLGL 77

                          90       100
                  ....*....|....*....|....*...
gi 1151112977 325 rNTCERLQALYGVEQKTRfcNRPEGGLA 352
Cdd:cd16945    78 -AFVQEVAQLHGGRITLR--NRPDGVLA 102
PRK10935 PRK10935
nitrate/nitrite two-component system sensor histidine kinase NarQ;
264-358 3.90e-03

nitrate/nitrite two-component system sensor histidine kinase NarQ;


Pssm-ID: 236800 [Multi-domain]  Cd Length: 565  Bit Score: 39.07  E-value: 3.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112977 264 LLQPIVE---NAIKYgiSQrewGGQITIKARVFA-GELLLEISDNGPGVPEAElARLGSgSGVGIRNtcERLQALYGveq 339
Cdd:PRK10935  472 LLQIIREatlNAIKH--AN---ASEIAVSCVTNPdGEHTVSIRDDGIGIGELK-EPEGH-YGLNIMQ--ERAERLGG--- 539

                          90
                  ....*....|....*....
gi 1151112977 340 KTRFCNRPEGGLAVHLRIP 358
Cdd:PRK10935  540 TLTISQPPGGGTTVSLTFP 558
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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