|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
26-396 |
9.21e-41 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 147.72 E-value: 9.21e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 26 LMPIMFAVFSGTMGIMAFVAIAGPLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSYaa 105
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSY-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 106 lclfidyslsTLLAATLVFIGLALLRGIVGAFYAAVPaTSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLA- 184
Cdd:cd17330 79 ----------VLLGLSRNLWLLFLARFLDGLTGGNVS-VAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSt 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 185 PLSLTIPLYITAILPAIAWLVLWRTLPatapqnirpstplkfsdeRLRRPMAIAFCAAFSVAIAQTTVGFVALDALDLAP 264
Cdd:cd17330 148 PYGYALPFLVAAALALLNLVLVLFFLP------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSP 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 265 NDAarvaGIALTLVGVALVISQSVLRKLQWP---PQRLIRYGSLVAAIGFGSTALAQTSWMIWASFAVAASGMGWIYPSL 341
Cdd:cd17330 210 SQI----GLLLALVGIAGILAQLLLIPRLAKrlgERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPAL 285
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1177840150 342 SALAANSVNPGEQGMAAGTVASVQGAGVISGPLIGTLLYEA-GIGLPYLLVAALLF 396
Cdd:cd17330 286 SALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFlGPGVPFLLAAGLLL 341
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
31-403 |
5.11e-33 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 127.31 E-value: 5.11e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 31 FAVFSGTMGIMAFVAIAGPLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSYAALCLFI 110
Cdd:cd17325 3 LALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 111 DYSLstllaatlvfigLALLRGIVGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAP-LSLT 189
Cdd:cd17325 83 SYWQ------------LLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADaLGYR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 190 IPLYITAILPAIAWLVLWRTLPATAPQNIRPSTPLKFSDERLR-----RPMAIAFCAAFSVAIAQTTVG-FVALDALDLA 263
Cdd:cd17325 151 APFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRlllrdRRLLALFLAIFVLAFAFGALEpFLPLYAAELG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 264 PNDAARVaGIALTLVGVALVISQSVLRKL--QWPPQRLIRYGSLVAAIGFGSTALAQTSWMIWASFAVAASGMGWIYPSL 341
Cdd:cd17325 231 GLSPAQI-GLLFGAQGLASALSQPPAGKLsdRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPAT 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1177840150 342 SALAANSVNPGEQGMAAGTVASVQGAGVISGPLIGTLLYEA-GIGLPYLLVAALLFFGGLYAA 403
Cdd:cd17325 310 LALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAfGFATPFLAAAALLLLAAVLFL 372
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
58-394 |
3.16e-31 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 122.74 E-value: 3.16e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 58 PWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSYaalclfidyslstLLAATLVFIGLALLRGIVGAF 137
Cdd:cd17388 37 ATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDY-------------LLMAFAPTLWWLYLGRIIAGI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 138 YAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAPLSLTIPLYITAILPAIAWLVLWRTLPATAPQN 217
Cdd:cd17388 104 TGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLVAAGLNGLNFLLGLFVLPESLPPE 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 218 IRPSTPLK----FSDERLRRP-------MAIAFCAAFSVAIAQTTVGFVALDALDLAPndaaRVAGIALTLVGVALVISQ 286
Cdd:cd17388 184 RRRAFRWRranpFGSLRWLTGfpgllglLAVFFLIQLIGQVPATTWVLFTEDRFDWSP----TMVGLSLAVFGLLHALFQ 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 287 SVLRKL---QWPPQRLIRYGSLVAAIGFGSTALAQTSWMIWASFAVAASGmGWIYPSLSALAANSVNPGEQGMAAGTVAS 363
Cdd:cd17388 260 AFVTGPiakRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALG-GIAGPALQGLLSRQVPENEQGELQGVLTS 338
|
330 340 350
....*....|....*....|....*....|....*
gi 1177840150 364 VQGAGVISGPLIGTLLYEAGI----GLPYLLVAAL 394
Cdd:cd17388 339 LTSLTSIIGPLLFTGIFAASPatwpGLAWIIGAAL 373
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
20-368 |
7.13e-29 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 115.46 E-value: 7.13e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 20 SPPSLSLMPIMFAVFSGTMGIMAFVAIAGPLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGF 99
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 100 TLSYAALCLFIDYSLstllaatlvfigLALLRGIVGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGF 179
Cdd:COG2814 86 ALGSLLCALAPSLWL------------LLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 180 VGLLAP-LSLTIPLYITAILPAIAWLVLWRTLPATAPQ---NIRPSTPLKFSDERLRRPMAIAFCAAFSVAIAQTTVGFV 255
Cdd:COG2814 154 GGLLADlFGWRWVFLVNAVLALLALLLLLRLLPESRPAaraRLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLY 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 256 ALDALDLAPNdaarVAGIALTLVGVALVISQSVLRKL--QWPPQRLIRYGSLVAAIGFGSTALAQTSWMIWASFAVAASG 333
Cdd:COG2814 234 LQEVLGLSAS----AAGLLLALFGLGGVLGALLAGRLadRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFG 309
|
330 340 350
....*....|....*....|....*....|....*
gi 1177840150 334 MGWIYPSLSALAANSVNPGEQGMAAGTVASVQGAG 368
Cdd:COG2814 310 FGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
29-401 |
7.39e-26 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 107.29 E-value: 7.39e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 29 IMFAVFSGTMGIMAFVAIAGPLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSYAAlcl 108
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLL--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 109 fidYSLSTLLAatlvfiGLALLRGIVGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAP-LS 187
Cdd:cd17489 78 ---YLLATSVA------LLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQhLG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 188 LTIPLYITAILPAIAWLVLW----RTLPATAPQNIRPSTPLKFSDERLRRPMAIAFCAAFSVAIAQTtvgFVALDALDLA 263
Cdd:cd17489 149 FAVLFIVAAVLALLALLLVFlvkdPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAIST---FLPLYAAERG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 264 PNDAarvaGIALTLVGVALVISQSVLRKL--QWPPQRLIRYGSLVAAIGFGSTALAQTSWMIWASFAVAASGMGWIYPSL 341
Cdd:cd17489 226 ISNA----GLFFTVYAIALLLSRPFSGKLsdRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPAL 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1177840150 342 SALAANSVNPGEQGMAAGTVASVQGAGVISGPLIGTLLYEA-GIGLPYLLVAALLFFGGLY 401
Cdd:cd17489 302 QALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELfGYRAMFLLAAVVVLLALVL 362
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
36-400 |
2.88e-20 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 91.52 E-value: 2.88e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 36 GTMGIMAFVAIAgpLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSYAALCLFidysls 115
Cdd:cd17329 14 GFFMVWPFMAIY--LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA------ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 116 tllAATLVFIGLALLRGIVGAFYAAVpatSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAPLSLTIPLYIT 195
Cdd:cd17329 86 ---HSPWLFAIALVLTGFGGGLFEPA---SEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 196 AILPAIAWLVLWRTLPATAP-------QNIRPSTPLKFSDERLRRPMAIAFCAAFSVAIAQTTVGFVALDALdlapNDAA 268
Cdd:cd17329 160 AVLFLLAALVLLFLLPETRPkrraaekTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEIL----GLGE 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 269 RVAGIALTLVGVALVISQSVLRKL--QWPPQRLIRYGSLVAAIGFGSTALAQTSWMIWASFAVAASGMGWIYPSLSALAA 346
Cdd:cd17329 236 SLLGLLLALNALLIVLLQFPVARLveRFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVA 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1177840150 347 NSVNPGEQGMAAGTVASVQGAGVISGPLIGTLLYE-AGIGLPYLLVAALLFFGGL 400
Cdd:cd17329 316 ALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDlLGPGLPWLILAALGLIAAA 370
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
29-400 |
1.69e-19 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 89.15 E-value: 1.69e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 29 IMFAVFSGTMGIMAFVAIAGPLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSyaalcl 108
Cdd:cd17324 4 LALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILG------ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 109 fidyslsTLLAATLV-FIGLALLRGIVGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAP-L 186
Cdd:cd17324 78 -------NLLAALAPsFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQlL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 187 SLTIPLYITAILPAIAWLVLWRTLPATAPQNIRPSTPLK-----FSDERLRRPMAIAFCAAFSVAIAQTTVGFVALDALD 261
Cdd:cd17324 151 GWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSsllllLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 262 LAPNDaarvAGIALTLVGVALVISQSVLRKL--QWPPQRLIRYGSLVAAIGFGSTALAQTSWMIWASFAVAASGMGWIYP 339
Cdd:cd17324 231 FSSSA----IIGLLLLFGVAGVVGSPLAGRLadRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHS 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1177840150 340 SLSALAAnSVNPGEQGMAAGTVASVQGAGVISGPLIGTLLYEAGIGLPYLLVAALLFFGGL 400
Cdd:cd17324 307 ALQTRVL-RLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLAL 366
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
29-400 |
2.48e-18 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 85.70 E-value: 2.48e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 29 IMFAVFSGTMGIMAFVAIAGPLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSyAALCL 108
Cdd:cd17474 4 VFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIG-GLLCG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 109 FIDyslstllaatlVFIGLALLRGIVGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAPLSL 188
Cdd:cd17474 83 LSD-----------SFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 189 TIPLYITAILPAIAWLVLWRTLPATAPQNIRPSTPLKFSDERL--RRPMAIAFCAAFSVAIAQTTVGFVALDALDLAPND 266
Cdd:cd17474 152 RYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKAlrGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGI 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 267 AARVAGIALTLVGVALVISQSVLRKLQ---WPPQRLIRYGSLVAAIGFGSTALAQTSWMIWASFAVAASGMGWIYPSLSA 343
Cdd:cd17474 232 SPIIIGLLFAGWSVLLALGSLFVGRLLkkrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTT 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1177840150 344 LAANSVNPGEQGMAAGTVASVQGAGVISGPLIGTLLYEAGIGLPYLLVAALLFFGGL 400
Cdd:cd17474 312 LVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAA 368
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
32-373 |
7.24e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 84.01 E-value: 7.24e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 32 AVFSGTMGIMAFVAIAGPLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSYAALCLFID 111
Cdd:pfam07690 5 AFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 112 YSLstllaatlvfigLALLRGIVGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAP-LSLTI 190
Cdd:pfam07690 85 LWL------------LLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASlFGWRA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 191 PLYITAILPAIAWLVLWRTLPATAPQNIRPSTPLKFSDERLRR--------PMAIAFCAAFSVAIAQTTVGFVALDALDL 262
Cdd:pfam07690 153 AFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKallrdpvlWLLLALLLFGFAFFGLLTYLPLYQEVLGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 263 APNDAARVAGIALTLVGVALVISQSVLRKLQWPPQRLIRYGS-LVAAIGFGSTALAQTSWMIWASFAVAASGMGWIYPSL 341
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLlILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPAL 312
|
330 340 350
....*....|....*....|....*....|..
gi 1177840150 342 SALAANSVNPGEQGMAAGTVASVQGAGVISGP 373
Cdd:pfam07690 313 NALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
33-400 |
1.55e-15 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 77.61 E-value: 1.55e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 33 VFSGTMGIMAFVAIAGPLAR----TLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSyAALCL 108
Cdd:cd17473 5 LLASTLTVMAGAAIAPALPAiaqhFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIG-GVAGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 109 FIDySLSTLLAAtlvfiglallRGIVGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAPLSL 188
Cdd:cd17473 84 FLD-SLYALLAS----------RALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGW 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 189 TIPLYITAILPAIAWLVlWRTLPATAPQNIRPSTPLKF-SDERLRRPMAIAFCAAFSVAIAQTTVGFVALDALDLAPNDA 267
Cdd:cd17473 153 RAPFLVYLLALPVLILV-LLFLPEPARKSKSAASPGAAtAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGS 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 268 ARVAGIALTLVGVALVISQSVLRKL--QWPPQRLIRYGSLVAAIGFGSTALAQTSWMIWASFAVAASGMGWIYPSLSALA 345
Cdd:cd17473 232 AALIGLALAIASLAGAIGALLFGRLkrRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWA 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1177840150 346 ANSVNPGEQGMAAGTVASVQGAGVISGPLIGTLL--YEAGIGLPYLLVAALLFFGGL 400
Cdd:cd17473 312 MSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLvnLTGGLSGAFLILGVLALVLAI 368
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
29-400 |
4.39e-15 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 76.06 E-value: 4.39e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 29 IMFAVFSGTMGIMAFVAIAGPLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSyaalcl 108
Cdd:COG2271 15 LFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA------ 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 109 fidyslSTLLAATLVFIGLALLRGIVGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAPLSL 188
Cdd:COG2271 89 ------TLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 189 TIPLYITAILPAIAWLVLwrtlpatapqnirpstplkfsdeRLRRPMAIAFCAAFSVAIAQTTVGFVALDALDLAPNDAA 268
Cdd:COG2271 163 WRAAFLILGLPGLLLALL-----------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 269 RVAGIALTLVGVALVISQSVLRKLQWPPQRLIRYGSLVAAIGFGSTALAQTSWMIWASFAVAASGMGWIYPSLSALAANS 348
Cdd:COG2271 220 LLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAEL 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1177840150 349 VNPGEQGMAAGTVASV-QGAGVISGPLIGTLLYEAGIGLPYLLVAALLFFGGL 400
Cdd:COG2271 300 FPKKARGTASGLVNTFgFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAAL 352
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
50-383 |
7.09e-15 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 75.72 E-value: 7.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 50 LARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPvllrgvgGFTLSYAALCLFidyslSTLLAATLVFIGLAL 129
Cdd:cd17331 26 LTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRA-------ALVLSFLSSALS-----YLLLAFASSVPMLFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 130 LRgIVGAFYAAVPAtSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAP-LSLTIPLYITAILPAIAWLVLWR 208
Cdd:cd17331 94 SR-LPSVFMHAMQA-AQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKkFGEQAAALVAAVGSLLSIVLVIL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 209 TLPA------TAPQNIRPSTPLKFSDERLRRP---------MAIAFCAAFSVAIAQTTVGFVALDALDLAPNDaarvAGI 273
Cdd:cd17331 172 LIPSntkskrEKEAKESASPPSVFNLKEILRLlrlpgvaflLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEE----NGY 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 274 ALTLVGVALVISQSVLRKL---QWPPQRLIRYGSLVAAIGFGSTALAQTSWMIWASFAVAASGMGWIYPSLSALAANSVN 350
Cdd:cd17331 248 LMSYAGVLGMVVQGLLVGPltkRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVP 327
|
330 340 350
....*....|....*....|....*....|...
gi 1177840150 351 PGEQGMAAGTVASVQGAGVISGPLIGTLLYEAG 383
Cdd:cd17331 328 PEDTGTALGLSHALFSLVRTVSPTIGGALLQAY 360
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
29-402 |
7.63e-15 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 75.66 E-value: 7.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 29 IMFAVFSGTMGIMAFVAIAGP-LARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSYAalc 107
Cdd:COG0738 12 AIYLLFFLWGFATALWGPLIPaLKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLL--- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 108 lfidyslstLLAATLVFIGLALLRGIVGAFYAAVPATSSALIADHiEPKKRASAMAAIGSASGAGMVIGPGFVGLLA--- 184
Cdd:COG0738 89 ---------LFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAAL-GPETAASRLNLLHAFFSLGALLGPLLGGLLIllg 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 185 -PLSLTIPLYITAILPAIAWLVLWRT-LPATAPQNIRPSTPLKFSDERLRRP-----MAIAFCAAFSVAIAQTTVGFVAL 257
Cdd:COG0738 159 lSLSWHLPYLILAVLLLLLALLFLRSkLPEIEEEEEEAAGSAASLKSLLKNPrlllgGLAIFLYVGAEGAIGDWLPLYLK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 258 DALDLAPNDAARVAGIALTLVGVALVISQSVLRKLqwPPQRLIRYGSLVAAIGFGSTALAQTSWMIWASFAVAASGMGWI 337
Cdd:COG0738 239 DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF--GPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLM 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1177840150 338 YPSLSALAANSVNPGEQGMAAGTVASVQGAGVISGPLIGTLLYEAGIGLPYLLVAALLFFGGLYA 402
Cdd:COG0738 317 FPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLA 381
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
29-380 |
1.23e-14 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 74.90 E-value: 1.23e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 29 IMFAVFSGTMGIMAFVAIAGPLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLsyAALCL 108
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGL--ASLLC 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 109 FIDYSLSTLLAAtlvfiglallRGIVGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAPLSL 188
Cdd:cd17321 79 ALAPSLAFLIAA----------RALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 189 TIPLYITAILPAIAWLVLWRTLPATapqnirpstplkfsderlrrpMAIAFCAAFSVAIAQTTVGFVALDALDLAPNDaa 268
Cdd:cd17321 149 WRWIFLINVPIGLVALLLARTFSGA---------------------VLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQ-- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 269 rvAGIALTLVGVALVISQSVLRKL--QWPPQRLIRYGSLVAAIGFGSTAL---AQTSWMIWASFAVAASGMGWIYPSLSA 343
Cdd:cd17321 206 --AGLALLPLALAMLVAAPLAGRLadRFGPRLVLVAGLLLTAVGLLLLALlgaDSSVWLLLPGLVLLGLGLGLFATPLTN 283
|
330 340 350
....*....|....*....|....*....|....*...
gi 1177840150 344 LAANSVNPGEQGMAAGTVASV-QGAGVISGPLIGTLLY 380
Cdd:cd17321 284 AALSSVPKEKAGAASGILNTArQLGGALGVALLGALLT 321
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
62-402 |
1.53e-14 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 74.61 E-value: 1.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 62 GAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRgvggftlsyAALCLFIDYSLSTLLAATLVFIGLALLRGIVGAFYAAv 141
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLR---------ASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVPN- 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 142 patSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAPL-SLTIPLYITAILPAIAWL-VLWRTLPATAPQNIR 219
Cdd:cd17391 109 ---ATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLfGIRNVFFITGGLLFLAFLlTLFFVKEDFKPVEKK 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 220 PSTPLKFSDERLRRPMAIA--FCAAFSVAIAQTTVG-FVALDALDLAPNDA--ARVAGIALTLVGVALVISQSVLRKL-- 292
Cdd:cd17391 186 KMVSTKEVWNSVPNPSLLIslFVTTFIIQLANQSIEpILTLYIRQLMGDASnlAFISGLVFSATGVSSLLSAPRLGKLgd 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 293 QWPPQRLIRYGSLVAAIGFGSTALAQTSWMIWASFAVAASGMGWIYPSLSALAANSVNPGEQGMAAGTVASVQGAGVISG 372
Cdd:cd17391 266 RIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAG 345
|
330 340 350
....*....|....*....|....*....|.
gi 1177840150 373 PLIGTLLYEA-GIGLPYLLVAALLFFGGLYA 402
Cdd:cd17391 346 PLLGSAIAAHfGYRAVFVVTALLVLLNAIWS 376
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
29-398 |
6.46e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 72.46 E-value: 6.46e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 29 IMFAVFSGTMGIMAFVAIAGPLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSYAALCL 108
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 109 FIDYSLstllaatlvfigLALLRGIVGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLA---P 185
Cdd:cd06174 81 APSFWL------------LLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAsslG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 186 LSLTIPLYITAILPAIAWLVLWRTLPATAPQNIRPSTPLKFSDERLRRPMAIAFCAAFSVAIAQTTVGFVALDALDLAP- 264
Cdd:cd06174 149 FGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPl 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 265 ------NDAARVAGIALTLVGVALVISQSVLRKL---QWPPQRLIRYGSLVAAIGFGSTALAQTSWMIWASFAVAASGMG 335
Cdd:cd06174 229 flldlgGLSVAVAGLLLSLFGLAGALGSLLLGLLsdrLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLG 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1177840150 336 WIYPSLSALAANSVNPGEQGMAAGTVASVQGAGVISGPLIGTLLYEAGIGLPYLLVAALLFFG 398
Cdd:cd06174 309 GLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLL 371
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
27-403 |
1.41e-13 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 71.86 E-value: 1.41e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 27 MPIMFAVFSGTMGIMAFVAIAGP-----LARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVG-----RRPVLLRGV 96
Cdd:COG2211 9 LKEKLAYGLGDLGLNLAFGLLSAyllyfYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 97 GGFTLSYAALclFIDYSLSTLLAATLVFIGLALLRGIVGAFYAAVPATSSALIADhiePKKRASAMAAIGSASGAGMVIG 176
Cdd:COG2211 89 IPLALSFVLL--FTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPD---YEERTRLSSWRFAFAGLGGLLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 177 PGFVGLL-------APLSLTIPLYITAILPAIAWLVLW-----RTLPATAPQNIRPSTPLKFSDERLRRPMAIAFCAAFS 244
Cdd:COG2211 164 SVLPPPLvaafggdAALGYRLTALIFAVLGLLAFLLTFfgtkeRPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 245 VAIAQTTVGFVALDALDLAPNDAARVAGIALTLVGVALVISQSVLRKlqWPPQRLIRYGSLVAAIGFGSTALAQTS--WM 322
Cdd:COG2211 244 LALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR--FGKKKAFIIGLLLAALGLLLLFFLGPGnlWL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 323 IWASFAVAASGMGWIYPSLSALAANSVNPGEQ---GMAAGTVASVQG---------AGVISGPLIGTLLYEAGIGLPYLL 390
Cdd:COG2211 322 LLVLAALAGIGLGAILVLPWAMLADVVDYDEWktgRRREGLYFGIFTfaiklgqalAGALAGLLLALFGYVAGAAQSPSA 401
|
410
....*....|...
gi 1177840150 391 VAALLFFGGLYAA 403
Cdd:COG2211 402 LTGIRLLFFLLPA 414
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
61-395 |
9.13e-13 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 69.17 E-value: 9.13e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 61 IGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLrgvggftlsyaaLCLFIdYSLSTLLAATLVFI-GLALLRGIVGAfyA 139
Cdd:cd17472 34 IGLALGIYGLTQAIFQIPFGLLSDRIGRKPVIL------------FGLLL-FIAGSLLAAYATSIyGLILGRALQGS--G 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 140 AVPATSSALIADHIEPKKRASAMAAIGSASG----AGMVIGPGFVGLLAPLSLtipLYITAILPAIAWLVLWRTLPATAP 215
Cdd:cd17472 99 AISSVVMALLADLTREENRTKAMALIGASIGiafaISMVLGPLLAAHLGVSGL---FLITAILSLVSLLILLFFVPDPPK 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 216 QNIRPSTPLKFSDERLRRPMAIAFCAAFSVAIAQTTVGFVA----LDALDLAPNDAARVAGIALtLVGVALVISQSVLRK 291
Cdd:cd17472 176 IVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYIlpllLTQLGGGKGQLWKVYLPAI-LIGFILMVPFVIYAE 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 292 LQWPPQRLIRYGSLVAAIGFGSTALAQTS-WMIWASFAVAASGMGWIYPSLSALAANSVNPGEQGMAAGTVASVQGAGVI 370
Cdd:cd17472 255 KKGKMKQVFVSSILLIAVGFLLLLFAATSlWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSF 334
|
330 340
....*....|....*....|....*
gi 1177840150 371 SGPLIGTLLYEAGIGLPYLLVAALL 395
Cdd:cd17472 335 LGGALGGLLWGLLGYSSVFLTILIL 359
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
31-403 |
5.75e-12 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 66.48 E-value: 5.75e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 31 FAVFSGTMGIMAFVAIAGPLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSYAalclfi 110
Cdd:cd17390 3 LVGFLDLFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYV------ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 111 dyslstLLAATLVFIGLALLRGIVGAFYAAVpATSSALIADHIEPKKRASAMAAIGSASGAGMVIGP-----------GF 179
Cdd:cd17390 77 ------LLGFSTSLALLFLSRIPLGIFKHTQ-SLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPvvgghlaetdgGF 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 180 --VGLLAPLSLTIPLYITAILPAIAWLVLwrtlpatapqnirpstplkfsderlrrpmAIAFCAAFSVAIAQTTVGFVAL 257
Cdd:cd17390 150 yyVALLCSAIFILNAGLVWFLLSKLWDLL-----------------------------LVRFLMGFSVLLFRSNFSLYLE 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 258 DALDLAPNDAARVAGIALTLVGVALVISQSVLRKLQWPPQRLIRYGSLVAAIGFGSTALAQTSWMIWASFAVAASGMGWI 337
Cdd:cd17390 201 ERFDLSPKTIGYLISYSGVLGALSGFLVGRILKLYKNNEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVL 280
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1177840150 338 YPSLSALAANSVNPGEQGMAAGTVASVQGAGVISGPLIGTLLYEAGIGLPYLLVAALLFFGGLYAA 403
Cdd:cd17390 281 RTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQEFSVSGPGLLGAVLALAAILLML 346
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
61-402 |
2.57e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 64.56 E-value: 2.57e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 61 IGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSYAALCLFIDYSLSTLLaatlVFIGLALLRGIVGAFYAA 140
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLW----LLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 141 vpaTSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLL-APLSLTIPLYITAILPAIAWLVLWRTLPATAPQNIR 219
Cdd:cd06173 112 ---ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLvALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGE 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 220 PSTPLKFSDE------RLRRPMAIAFCAAFSVAIAQTTVGFVALDALDLAPNDAARVAGIALTLVGVALVISQSVLRKL- 292
Cdd:cd06173 189 SSSLLLRDLReglrylRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLs 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 293 -QWPPQRLIRYGSLVAAIGFGSTALAQTSWMIWASFAVAASGMGWIYPSLSALAANSVNPGEQG-MAAGTVASVQGAGVI 370
Cdd:cd06173 269 kRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGrVFSVYNALNSGAMPL 348
|
330 340 350
....*....|....*....|....*....|..
gi 1177840150 371 SGPLIGTLLYEAGIGLPYLLVAALLFFGGLYA 402
Cdd:cd06173 349 GALLAGLLADALGLSAVFLLAGALLLLAALLL 380
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
74-397 |
3.34e-11 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 64.22 E-value: 3.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 74 ICARWWGGLSDKVGRRPVLLRGVGGFTLSYAalclfidyslstlLAATLVFIGLALLRGIVGAFYAAVPATSSALIADHI 153
Cdd:cd17389 79 LSSPITGAASDVYGRKPVLLLTMIGLAISYA-------------LWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVT 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 154 EPKKRASAMAAIGSASGAGMVIGPGFVGLLAPLSLT-------IPLYITAILPAIAWLVLWRTLPATAPQNirpstplkf 226
Cdd:cd17389 146 SPKKRSKGMALIGVAFSLGFIIGPMIGAYFASFTRSlgevffsMPALFALVLALADLLFIFFFLPETLPSN--------- 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 227 sderLRRPMAIAFCAAFSVAIAQTTVGFVALDALDLAPNDAARVagiaLTLVGVALVISQS--VLRKLQWPPQRLIRYGS 304
Cdd:cd17389 217 ----LRRLGLVYFLYLFLFSGLEFTLTFLTHQRFQYTSMQQGKM----FFFIGIIMALVQGgyVRRIKPGKEKKAVLQGL 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 305 LVAAIGFGSTALAQTSWMIWASFAVAASGMGWIYPSLSALAANSVNPGEQGMAAGTVASVQGAGVISGPLIGTLLY-EAG 383
Cdd:cd17389 289 ILLIPAFLLIGWASSVTVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVYwLAG 368
|
330
....*....|....
gi 1177840150 384 IGLPYLLVAALLFF 397
Cdd:cd17389 369 SEACYTIGALLFLL 382
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
78-400 |
4.19e-11 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 64.13 E-value: 4.19e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 78 WWGGLSDKVGRRPVLLRGVGGFTLSyAALCLFIDySLSTLLAAtlvfiglallRGIVGAFYAAVPATSSALIADHIEPKK 157
Cdd:cd17320 53 LYGPLSDRFGRRPVLLAGLLLFILA-SLLCALAS-SIEQLLIA----------RFLQGLGAAAGSVVARAIVRDLYSGAE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 158 RASAMAAIGSASGAGMVIGPGFVGLLAP-LSLTIPLYITAILPAIAWLVLWRTLPATAP-QNIRPSTPLKFSDERL---- 231
Cdd:cd17320 121 LAKIFSLLMMILAIAPALAPLLGGLLLLfFGWRAIFVFLALLGLLLLLLVLLFLPETLPeEKRKPLLSSLLRAYKRvlkn 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 232 RRPMAIAFCAAFSVAIAQTTVG---FVALDALDLAPNDAARVAGIALTLVGVALVISQSVLRKlqWPPQRLIRYGSLVAA 308
Cdd:cd17320 201 RRFLGYALALGLSFAGLFAYLAaapFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRR--FGPRRLLRLGLLLLL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 309 IGFGSTALAQ-----TSWMIWASFAVAASGMGWIYPSLSALAAnSVNPGEQGMAAGTVASVQGAGVISGPLIGTLLYEAG 383
Cdd:cd17320 279 AAALVLLLAAllgglSLWPLVAPLFLIFFGFGLIFPNATSLAL-EPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGT 357
|
330
....*....|....*..
gi 1177840150 384 IGLPYLLVAALLFFGGL 400
Cdd:cd17320 358 ALPMGLLILVLGLLALL 374
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
20-394 |
1.42e-10 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 62.39 E-value: 1.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 20 SPPSLSLMPIMFAVFSGTMGI-MAFVAIAGPLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGG 98
Cdd:PRK12382 11 SSANFSLFRIAFAVFLTYMTVgLPLPVIPLFVHHDLGFGNTMVGIAVGIQFLATVLTRGYAGRLADQYGAKRSALQGMLA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 99 FTLSYAALCLFIDYSLSTLLAATLVFIGlallRGIVGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGpG 178
Cdd:PRK12382 91 CGLAGLAYLLAAILPVSAPFKFALLVVG----RLILGFGESQLLTGALTWGLGLVGPKHSGKVMSWNGMAMYGALAAG-A 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 179 FVGLL--APLSLTIPLYITAILPAIAWLVLwRTLPATAPQnirpstplkfSDERLRRPMAIAFCAAFSVAIAQTTVGFVA 256
Cdd:PRK12382 166 PLGLLlhSHFGFAALALTTMVLPLLAWAFN-GTVRKVPAH----------AGERPSLWSVVGLIWKPGLGLALQGVGFAV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 257 LDA---LDLAPNDAArVAGIALTLVGVALVISQSVLrklQWPPQRL-----IRYGSLVAAIGFGSTALAQTSWMIWASFA 328
Cdd:PRK12382 235 IGTfvsLYFASKGWA-MAGFTLTAFGGAFVLMRVLF---GWMPDRFggvkvAIVSLLVETVGLLLLWLAPTAWVALAGAA 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1177840150 329 VAASGMGWIYPSLSALAANSVNPGEQGMAAGTVASVQG-AGVISGPLIGTLLYEAGIGLPYLLVAAL 394
Cdd:PRK12382 311 LTGAGCSLIFPALGVEVVKRVPSQVRGTALGGYAAFQDiAYGVSGPLAGMLATSFGYPSVFLAGAIS 377
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
31-404 |
1.51e-10 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 62.21 E-value: 1.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 31 FAVFSGTMGIMAFVAIAGPLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSYAALCLFI 110
Cdd:COG2223 12 LAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 111 DYSLstllaatlvfigLALLRGIVGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLL-APLSLT 189
Cdd:COG2223 92 SYWL------------LLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLiAAFGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 190 IPLYITAILPAIAWLVLWRTLPATAPQNIRPS-TPLKFSDERLRRPMAIAFCAAFSVaiaqTTVGFVAL---------DA 259
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFLRDPPAGAAAAAkASLRDQLEALRDPRFWLLSLLYFG----TFGSFIGFsswlppylvDQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 260 LDLAPNDAARVAGIALTLVGVALVISQSVLRKLqWPPQRLIRYGSLVAAIGFGSTALAQTSWMIWASFAVAASGMGWIYP 339
Cdd:COG2223 236 FGLSAATAGLLAALFALLGALGRPLGGWLSDRI-GGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNG 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1177840150 340 SLSALAANSVNPGEQGMAAGTVASVQGAGVISGPLIGTLLYEAGIGlpylLVAALLFFGGLYAAG 404
Cdd:COG2223 315 AVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGS----YTAAFLVFAVLALVA 375
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
58-400 |
4.14e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 61.04 E-value: 4.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 58 PWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSYAALCLFIDYSLstllaatlvfigLALLRGIVGAF 137
Cdd:cd17477 30 TALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWV------------WFLLRFVMGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 138 YAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAPLSLTiPLYITAILPAIAWLVLWRTLPATAPQN 217
Cdd:cd17477 98 LAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGAL-PFLIAAVLLLLALVPLLLTRRAAPEIE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 218 IRPSTPLKfsdeRLRRPMAIAFCAAFSVAIAQTT-VGFVALDALDLAPNDAArvAGIALTLVGVALVISQSVLRKL--QW 294
Cdd:cd17477 177 EAESISLR----RLLRIAPLALLGAFVAGFLEGAfYSLLPLYGLRLGLSVAQ--AALLLAAFVLGGLLLQWPLGWLadRF 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 295 PPQRLIRYGSLVAAIGF-GSTALAQTSWMIWASFAVAASGMGWIYPSLSALAANSVNPGEQGMAAGTVASVQGAGVISGP 373
Cdd:cd17477 251 DRRRVLLGCALLGALAAlLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGP 330
|
330 340
....*....|....*....|....*....
gi 1177840150 374 LIGTLLYEA--GIGLPYLLVAALLFFGGL 400
Cdd:cd17477 331 LLAGALMDAfgPHGLFLFLAAVALLFLLF 359
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
80-213 |
2.00e-08 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 52.65 E-value: 2.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 80 GGLSDKVGRRPVLLRGVGGFTLSYAalclfidyslstLLAATLVFIGLALLRGIVGAFYAAVPATSSALIADHIEPKKRA 159
Cdd:TIGR00880 19 GLLTDRFGRKPVLLVGLFIFVLSTA------------MFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERG 86
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1177840150 160 SAMAAIGSASGAGMVIGPGFVGLLAP-LSLTIPLYITAILPAIAWLVLWRTLPAT 213
Cdd:TIGR00880 87 VALGLMSAGIALGPLLGPPLGGVLAQfLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
50-323 |
3.86e-08 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 54.86 E-value: 3.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 50 LARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDK-VGRRPVLLRGVGGFTLSYAALCLFIDYSLstLLAATLVFIGLa 128
Cdd:cd17471 23 LTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFAFLRNYWV--LLLVGVVLLSL- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 129 llrgivGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAP-LSLTIPLYITAILPAIAWLVLW 207
Cdd:cd17471 100 ------GAAAFPQLFALAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDvLGFTGLFLLAALLYLVVALLVL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 208 RTLPATAPQNIRPSTPLKFSDERLRRPMaIAFCAAFSVAIAQTTVGFVAL-----DALDLAPNDAARVAGI-ALTLVGVA 281
Cdd:cd17471 174 FLLPSVKPPAQKATPASSLVKAPVNRRL-LLLFAAFTLLFAANSMYIIAMplyvtNELGGSESWVGLLFGLaAALEIPIM 252
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1177840150 282 LVisqSVLRKLQWPPQRLIRYGSLVAAIGFGSTALAQTSWMI 323
Cdd:cd17471 253 LL---AGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQL 291
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
14-317 |
1.17e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 52.89 E-value: 1.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 14 SDDKQESPPSLSLMPIMFAVFSGTMGIMAFVAIAGPLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLL 93
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 94 RGVGGFTLSyaalclfidyslSTLLAATLVFIGLALLRGIVGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGM 173
Cdd:COG0477 84 IGLLLFGLA------------SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 174 VIGPGFVGLLAPLSLTIPLYITAILPAIAWLVLWRTLPATAPQNIRPSTPLKFSDERLRRPMAIAFCAAFSVAIAQTTVG 253
Cdd:COG0477 152 ALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLA 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1177840150 254 FVALDALDLAPNDAARVAGIALTLVGVALVISQSVLRKLQWPPQRLIRYGSLVAAIGFGSTALA 317
Cdd:COG0477 232 LLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
38-400 |
3.29e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 51.84 E-value: 3.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 38 MGIMAFVAIAGPLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLrGVGGFTLSYAALCLFIDYSLSTL 117
Cdd:cd17490 10 FSQYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFI-IIGLLFTVLASLIMILFPSPWGL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 118 LAATLvfiglalLRGIVGAFYaaVPATSsaLIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAP-LSLTIPLYITA 196
Cdd:cd17490 89 LIARF-------LSGIAAATW--VSFTV--LYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEhFGMRAPFLLAA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 197 ILPAIAWLVLWRTLPATAPQNIRPSTPLK-FSDERLRRPMAIAFCAAFSVAIA-QTTVGFVALDALDLAPNDAA-RVAGI 273
Cdd:cd17490 158 LAGVLGFILSLFIKEERREKKPVLTELKElLSVLKDKKLLFFSLLAILQQMITfSTTFGFTPLIAKQLGASSFQlGLLSI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 274 ALTLVGVALVISQSVLRKLQWPPQRLIRYGSLVAAIGFGSTALAQTSWMIWASFAVAASGMGWIYPSLSALAANSVNPGE 353
Cdd:cd17490 238 IYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQ 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1177840150 354 QGMAAGTVASVQGAGVISGPLI-GTLLYEAGIGLPYLLVAALLFFGGL 400
Cdd:cd17490 318 RSTAMGFFQAIYALGMFLGPVLvGIISEAFGLQTGFFVIGVIALLAAI 365
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
38-400 |
4.23e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 51.45 E-value: 4.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 38 MGIMAFVAIAGPLART--LALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSyaalclfidyslS 115
Cdd:cd17316 13 YDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLA------------T 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 116 TLLAATLVFIGLALLRGIVGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAPLSLT-----I 190
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGdwgwrI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 191 PLYITAILPAIAWLVLWRTLpatapqnirpstplkfsderlrRPMAIAFCAAFSVAIAQTTVGFVALDALDLAPNDAARV 270
Cdd:cd17316 161 LFLIGALPALLALLLRRRTL----------------------LLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLY 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 271 AGIALTLVGVALVISQSVLRKLQWPPQRLIRYGSLVAAIGFGSTALAQTSWMIWASFAVAASGMGWIYPSLSALAANSVN 350
Cdd:cd17316 219 LLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFP 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1177840150 351 PGEQGMAAGTVASVQGAG-VISGPLIGTLLYEAGIGLPYLLVAALLFFGGL 400
Cdd:cd17316 299 TEVRATGVGLSYNLGRLGgGGAPPLIALLLASTGGTGVPALILALLAIVAL 349
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
26-177 |
3.06e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.95 E-value: 3.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 26 LMPIMFAVFSGTMGIMAFVAIAGPLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSYAA 105
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALG 281
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1177840150 106 LCLFIDYSLSTLLAATLVFIGLAllrgivgafYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGP 177
Cdd:pfam07690 282 LLLLSLTLSSLWLLLALLLLGFG---------FGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
17-207 |
8.01e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 47.54 E-value: 8.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 17 KQESPPSLSLMPIMFAVFSGTMGIMAFVAIAGPL----ARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVL 92
Cdd:cd17370 188 KKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFlilrAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLL 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 93 LRGVGGFTLSYAALCLFIDyslstllaATLVFIGLALLrgivGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAG 172
Cdd:cd17370 268 ILGYLSLALAYLGFALGSS--------LWLLLLGFILW----GLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIG 335
|
170 180 190
....*....|....*....|....*....|....*.
gi 1177840150 173 MVIGPGFVGLLAPL-SLTIPLYITAILPAIAWLVLW 207
Cdd:cd17370 336 WLLASLIAGYLWDLiSPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
5-139 |
1.24e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 47.14 E-value: 1.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 5 ADQPAQTPLSDDKQESPPSLSLMPIMFAVFSGTMGIMAFVAIAGpLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSD 84
Cdd:cd17369 211 AGQVVRAPLVEVLRRHWRALLLAIGLRLAENVLFYLFTTFALSY-ATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSD 289
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1177840150 85 KVGRRPVLLRGVGGFTLSYAALCLFIDYS---LSTLLAATLVFIGLALLRGIVGAFYA 139
Cdd:cd17369 290 RVGRRPVYLAGALLAALFAFPFFWLLDTGstwLIVLAAVVVLGVLHGMMYGPQAAFLA 347
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
24-214 |
1.31e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.79 E-value: 1.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 24 LSLMPIMFAVFSGTMGIMAFVAIAGP-LARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLrgVGGFTLS 102
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLV--LAIGLLL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 103 YAALCLFIDYSLSTLLAATLVFIGLALLRGIVGAFYAavpatssaLIADHIEPKKRASAMAAIGSASGAGMVIGPGFVG- 181
Cdd:COG2271 258 AALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWA--------LAAELFPKKARGTASGLVNTFGFLGGALGPLLVGy 329
|
170 180 190
....*....|....*....|....*....|...
gi 1177840150 182 LLAPLSLTIPLYITAILPAIAWLVLWRTLPATA 214
Cdd:COG2271 330 LLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
74-402 |
1.44e-05 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 46.84 E-value: 1.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 74 ICARWWGGLSDKVGRRPVLLRgvggftlsyAALCLFIDYSLSTLLAATLVFIGLALLRGIVGAFyaaVPaTSSALIADHI 153
Cdd:PRK09874 69 IASPFWGGLADRKGRKIMLLR---------SALGMGIVMVLMGLAQNIWQFLILRALLGLLGGF---VP-NANALIATQV 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 154 EPKKRASAMAAIGSASGAGMVIGPGFVGLLAP-LSLTIPLYITAILPAIAWLVLWRTLpataPQNIRPSTPLKFSDER-- 230
Cdd:PRK09874 136 PRNKSGWALGTLSTGGVSGALLGPLAGGLLADsYGLRPVFFITASVLFLCFLVTLFCI----RENFQPVSKKEMLHMRev 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 231 ---LRRPMAI--AFCAAFSVAIAQTTVG-FVALDALDLAPN--DAARVAGIALTLVGVALVISQSVLRKL--QWPPQRLI 300
Cdd:PRK09874 212 vtsLKNPKLVlsLFVTTLIIQVATGSIApILTLYVRELAGNvsNIAFISGMIASVPGVAALLSAPRLGKLgdRIGPEKIL 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 301 RYGSLVAAIGFGSTALAQTSWMIWASFAVAASGMGWIYPSLSALAANSVNPGEQGMAAGTVASVQGAGVISGPLIGTLLY 380
Cdd:PRK09874 292 ITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAIS 371
|
330 340
....*....|....*....|...
gi 1177840150 381 EA-GIGLPYLLVAALLFFGGLYA 402
Cdd:PRK09874 372 ANyGFRAVFLVTAGVVLFNAVYS 394
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
44-400 |
1.66e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 46.41 E-value: 1.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 44 VAIAGP-LARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLsyaalclfidysLSTLLAATL 122
Cdd:cd17319 22 ISVAAPtIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL------------FTALTGFAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 123 VFIGLALLRGIVGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAPLSLTIPLYITAILPAIA 202
Cdd:cd17319 90 SLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 203 WLVLWrtlpatapqnirpstplkfsdeRLRRPMAIAFCAAFSvAIAQTTVGFVA------LDALDLAPNDAARVAGIALT 276
Cdd:cd17319 170 LAVLW----------------------WFYLRQVWGLALGYF-GINYALYGLLTwlptylKQARGFSLKQVGLLAAIPFL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 277 LVGVALVISQSVLRKLQWPPQRL-IRYGSLVAAIGFGSTALAQTSWMIWASFAVAASGMGWIYPSLSALAANSVNPGEQG 355
Cdd:cd17319 227 AGAIGMILGGRLSDRLLRGARRLvIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAA 306
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1177840150 356 MAAGTVASVQGAGVISGPLIGTLLYEAGIG--LPYLLVAALLFFGGL 400
Cdd:cd17319 307 TAGGLINSGGNLGGFVAPLLIGYLVDATGSytAAFLFLAAVALLAAL 353
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
29-209 |
1.74e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 46.41 E-value: 1.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 29 IMFAVFSGTMGIMAFVAIAGPLARTLA-LEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSYAALC 107
Cdd:COG2223 210 LSLLYFGTFGSFIGFSSWLPPYLVDQFgLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLA 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 108 LFidysLSTLLAATLVFIglallrgIVGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAPL- 186
Cdd:COG2223 290 LA----LGSLWLFLVLFL-------LLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAt 358
|
170 180
....*....|....*....|....
gi 1177840150 187 -SLTIPLYITAILPAIAWLVLWRT 209
Cdd:COG2223 359 gSYTAAFLVFAVLALVALVLTLLL 382
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
40-214 |
2.02e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 46.58 E-value: 2.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 40 IMAFVAIAgpLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLsyaalclfidysLSTLLA 119
Cdd:TIGR00895 35 AMGFAAPA--ISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSV------------FTLLCA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 120 ATLVFIGLALLRGIVGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAP-LSLTIPLYITAIL 198
Cdd:TIGR00895 101 LATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPvFGWRSLFYVGGIA 180
|
170
....*....|....*.
gi 1177840150 199 PAIAWLVLWRTLPATA 214
Cdd:TIGR00895 181 PLLLLLLLMRFLPESI 196
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
31-400 |
2.42e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.00 E-value: 2.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 31 FAVFSGTMGIMAFVAIAGPLARTLALEPWHIGAAMTVGGFTWVIcARWWGG-LSDKVGRRPVLLrgVGGFTLSYAALCLf 109
Cdd:cd17370 6 LVSLFADISYEMARSILPLFLVVLGASAAAVGLIEGLAEALGSL-LRLFSGyLSDRTGKRKPLV--ILGYGLSALAKPL- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 110 idyslstlLAATLVFIGLALLRgIVGAFYAAVPATS-SALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAPL-- 186
Cdd:cd17370 82 --------LALAGSWQLVLLLR-ILERLGKGIRTPPrDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLlg 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 187 -SLTIPLYITAILPAIAWLVLWRTLPATAPQNIRPSTPLKFSDERLRRPMAIAFCAAFSVAIAQTTVGFVALDALDLAPN 265
Cdd:cd17370 153 gNYRTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLILRAQELGLS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 266 DAarVAGIALTLVGVALVISQSVLRKL--QWPPQRLIRYGSLVAAIGFGSTALAQTSWMIWASFAVAASGMGWIYPSLSA 343
Cdd:cd17370 233 AA--LIPLLYALFNLVYALAAYPAGRLsdRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERA 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1177840150 344 LAANSVNPGEQGMAAGTVASVQGAGVISGPLIGTLLYEA-GIGLPYLLVAALLFFGGL 400
Cdd:cd17370 311 AVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLiSPSAAFLFSAVLALIALL 368
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
239-402 |
9.26e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 44.33 E-value: 9.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 239 FCAAFSVAIAQTTVGFVALDALDLAPNDAARVAGIALTLVGVALVISQSVLRKLQ--WPPQRLIRYGSLVAAIGFGSTAL 316
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSdrFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 317 AQTSWMIWASFAVAASGMGWIYPSLSALAANSVNPGEQGMAAGTVASVQGAGVISGPLIGTLLYEA-GIGLPYLLVAALL 395
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLfGWRAAFLILAILS 161
|
....*..
gi 1177840150 396 FFGGLYA 402
Cdd:pfam07690 162 LLAAVLL 168
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
29-211 |
9.92e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 44.10 E-value: 9.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 29 IMFAVFSGTMGImafvAIAGPLARTLAlEPWHIGAAM---TVGGFTWVICAR--WWGGLSDKVGRRPVLLrgvggftlsy 103
Cdd:cd17323 4 ISFLTFVVTFGS----SIYSPALPQIA-EDFHVSEEVanlGVSLFVLGFGLGplIWAPLSELYGRRPVYL---------- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 104 AALCLFIDYSLSTLLAATLVfiGLALLRGIVGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLL 183
Cdd:cd17323 69 VSLFIFVIFQIGCALAPNIA--MLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFI 146
|
170 180
....*....|....*....|....*....
gi 1177840150 184 A-PLSLTIPLYITAILPAIAWLVLWRTLP 211
Cdd:cd17323 147 TqSLGWRWIFWFLAIISGFCLILIFLFLP 175
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
227-406 |
1.64e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.42 E-value: 1.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 227 SDERLRRPMAIAFCAAFSVAIAQTTVGFVALDALDLAPNDAARVAGIALTLVGVALVISQSVLRKL--QWPPQRLIRYGS 304
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLadRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 305 LVAAIGFGSTALAQTSWMIWASFAVAASGMGWIYPSLSALAANSVNPGEQGMAAGTVASVQGAGVISGPLIGTLLYEA-G 383
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLfG 162
|
170 180
....*....|....*....|...
gi 1177840150 384 IGLPYLLVAALLFFGGLYAAGHV 406
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLL 185
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
79-361 |
1.95e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 43.32 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 79 WGGLSDKVGRRPVLLRGVGGFTLSyAALCLFIDySLSTLLAAtlvfiglallRGIVGAFYAAVPATSSALIADHIEPKKR 158
Cdd:cd17502 50 YGKLSDLFGRKWVLLIAIVIFELG-SLLCGLAP-NMTMLIVG----------RAIQGIGGGGLMSLAFIIIADLVPPRER 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 159 ASAMAAIGSASGAGMVIGPGFVGLLAP---------LSLTIPLYITAILPAIAWLVLwrtlpatapqnirpstplkfsde 229
Cdd:cd17502 118 GKYQGYIGAVFGIASVAGPLIGGAFTDhlswrwcfyINLPIGGLALALLRTILLSSI----------------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 230 rlrrpMAIAFCAAFSVAI------AQTTVGFVALDAldlapndAARVAGIALTLVGVALVISQSVLRKLQWPPqrLIRYG 303
Cdd:cd17502 175 -----FGFLFGGALFGLIyylplyFQLVLGDSATKS-------GVRLLPLIIGLVIGSIISGALISKTGRYKP--LIVIG 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1177840150 304 SLVAAIGFG---STALAQTSWMIWASFAVAASGMGWIYPSLSALAANSVNPGEQGMAAGTV 361
Cdd:cd17502 241 TILMSVGAGlltTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATN 301
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
21-173 |
2.22e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.04 E-value: 2.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 21 PPSLSLMPIMFAVFSGTMGIMAFVAIAgpLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFT 100
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLY--LQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLA 284
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1177840150 101 LSYAalclfidyslstLLAATLVFIGLALLRGIVGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGM 173
Cdd:COG2814 285 LGLL------------LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
80-400 |
2.76e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.93 E-value: 2.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 80 GGLSDKVGRRPVLLRGVGGFTLSYAALCLFIDYslsTLLAATLVFIGLAllrgiVGAFYAAvpatsSALIADHIEPKKRA 159
Cdd:cd17478 52 GYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNY---WLLLLLVALAGIG-----SAAFHPE-----GARLASQAAGGRRG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 160 SAMAAIGSASGAGMVIGPGFVGLLAPLSLTIPLYITAILPAIAWLVLWRTLPATAPQNIRPSTPLKFSDERLR---RPMA 236
Cdd:cd17478 119 LAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKgvwRALL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 237 IAFCAAFSVAIAQTTVGfVALDALDLAPNDAARVAGIALTLVGVALVISQSVLRKL--QWPPQRLIRYGSLVAAIGFGST 314
Cdd:cd17478 199 LLLIIVFLRSWVLSSLT-TFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLsdRFGRRRVIIASLLLAAPFLLLF 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 315 ALAQTSWMIWASFAVAASGMGwiYPSLSALAANSVNPGEQGMAAG-TVASVQGAGVISGPLIGTLLYEAGIGLPYLLVAA 393
Cdd:cd17478 278 LLTPGIWSYILLVLAGFLLFA--SFPVTVVLAQELLPGNVGLASGlMMGLSFGLGGIGAPVLGALADAFGLESVLLILAL 355
|
....*..
gi 1177840150 394 LLFFGGL 400
Cdd:cd17478 356 LPLLGAL 362
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
28-207 |
2.98e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.55 E-value: 2.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 28 PIMFAVFSGTMGIMAFVAIAGPLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLrgvgGFTLSYAALC 107
Cdd:cd17477 192 LALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLL----GCALLGALAA 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 108 LFIDYSLSTLLAAtlvFIGLALLRGIVGAFYAavpaTSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAPLS 187
Cdd:cd17477 268 LLLPLVPGLPLAL---LVLLFLWGGAAGPLYT----LALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAF 340
|
170 180
....*....|....*....|
gi 1177840150 188 LTIPLYITAILPAIAWLVLW 207
Cdd:cd17477 341 GPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
30-401 |
3.03e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 42.61 E-value: 3.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 30 MFAVFSGTMGI-------MAFVAiagPLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSD----KVGRR-PVLLRGVG 97
Cdd:cd17313 1 LFLLGFGFFGIefgwaleNSYVP---PILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDrcnsRIGRRrPFILVGAP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 98 GFTLS------YAALCLFIDYSLSTLLAATLVfIGLALLRgivgAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGA 171
Cdd:cd17313 78 LAALGlilipnAADIGLALGDGPRTWALVLFV-LGIVLLD----FAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 172 GMVIG---------PGFVGLLAPLSLTIPLYITAILPAIAWLVLWRTLP----ATAPQNIRPSTPLKFSDERLRRPMAIA 238
Cdd:cd17313 153 GGVLGyllgailwdHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKepplSPEAGEHSENPSLGEVLKSLLKLLKIM 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 239 FCAAFSVAIAQ--TTVGFVALDALD----------------LAPNDAARVAGIALTLVGVALVISQSVLRKL--QWPPQR 298
Cdd:cd17313 233 PRSLLRLLLVIffWWIAFFPFELFFtdymgeevyhgtsaasSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLgkKIGRKK 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 299 LIRYGSLVAAIGFGSTALAQTSWMIWASFAVAasGMGWI------YPSLSALAANSVnpGEQGMAAGTVAS-VQGAGVIS 371
Cdd:cd17313 313 VYLIGLVLFAVGMALMALVHNVTVALVLFALG--GIGWAtininpYPLVSDYHSESG--RGQGTDTGLLNLaISLAQILV 388
|
410 420 430
....*....|....*....|....*....|...
gi 1177840150 372 GPLIGTLLY--EAGIGLPYLLVAALL-FFGGLY 401
Cdd:cd17313 389 SLLAGPIIDvkGYGTVFPVAAVASFLsLVGALF 421
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
80-394 |
3.09e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 42.69 E-value: 3.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 80 GGLSDKVGRRPVLlrgVGGFTLSYAALCLFIDYSLSTLLAATLVFIGLALlrgivgafyAAVPATSSALIADHIePKKRA 159
Cdd:cd17333 52 GFLMKRLGRRRTL---ILGLLLISLALALIFATPSIYLFVVLMFLAGLGA---------GILDTGANTFVGALF-EESSA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 160 SAMAAIGSASGAGMVIGPGFVGLLAPLSLT------IPLYITAILPAIAWLVLWRTLPATAPQNIRPSTPLKFSDERLRR 233
Cdd:cd17333 119 TRLNVLHGFFGLGALIGPLIATSLLTSELSwswaylIIGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRN 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 234 PMAIAFC-AAFSVAIAQTTVGFVALDALDLAPNDAARVAGIALTLVGVALVISqsvlRKLQWPPQRLIRYGSLVAAIGFG 312
Cdd:cd17333 199 PSIILGAlALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIG----RLLGGPISRRIKPHTLLVLSGSG 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 313 STALAQTSWM----IWASFAVAASG--MGWIYPSLSALAAnSVNPGEQGMAAGTVASVQG-AGVISGPLIGTLLYEAGIG 385
Cdd:cd17333 275 ALLGLLILLLaptlVVGLVATALLGlfMAALFPTILSLGI-SNLPYAKGKGTSVLLAAGSiGGAIIPFIMGFIAEAVGIQ 353
|
....*....
gi 1177840150 386 LPYLLVAAL 394
Cdd:cd17333 354 TAMLLITIL 362
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
29-404 |
3.38e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 42.55 E-value: 3.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 29 IMFAVFSGTMGIMAFVAIAGPLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSYAalcl 108
Cdd:COG2807 23 IVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLL---- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 109 fidyslstLLAATLVFIGLALLRGIVGAFYAAVPATSSALIADHIePKKRASAMAAIGSASGAGMVIGPGFVGLLAP-LS 187
Cdd:COG2807 99 --------LRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAaLG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 188 LTIPLYITAILPAIA---WLVLWRTLPATAPQNIRPSTPLKFSdeRLRRPMAIAFCAAFSVAIAQTTVGFVA--LDALDL 262
Cdd:COG2807 170 WRGALAVWALLALLAlllWLPLLRRRPAAAAAAPAAASLRSLW--RSPLAWLLTLFFGLQSLLYYAVVAWLPpiLRDAGL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 263 APNDAARVAGIaLTLVGVALVISQSVLRKLQWPPQRLIRYGSLVAAIGFGSTALAQTSWMIWASFAVAASGMGWIYPSLS 342
Cdd:COG2807 248 SAATAGLLLSL-FQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALT 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1177840150 343 ALAANSVNPGEQGMAAGTVASVQGAGVISGPLIGTLLYEA--GIGLPYLLVAALLFFGGLYAAG 404
Cdd:COG2807 327 LIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDAtgSWTAALLLLAALAVLMLVAGLL 390
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
60-243 |
3.99e-04 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 42.23 E-value: 3.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 60 HIGAAMTV---GG--FTWVIcarwwGGLSDKVGRRPVLLRGVggftlsyaalCLFIDYSLSTLLAATL-VFIGLALLRGI 133
Cdd:PRK15402 49 WVPTSMTAylaGGmfLQWLL-----GPLSDRIGRRPVMLAGV----------AFFILTCLAILLAQSIeQFTLLRFLQGI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 134 VGAFYAAVpatSSALIADHIEPKKRASAMAAIGSASgagmVIGPgfvgLLAPLSLTIPLYIT---------AILPAIAWL 204
Cdd:PRK15402 114 GLCFIGAV---GYAAIQESFEEADAIKITALMANVA----LLAP----LLGPLVGAALIHVLpwrgmfvlfAALAALSFF 182
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1177840150 205 VLWRTLPATAPQnIRPSTPLK--FSDERL----RRPMAIAFCAAF 243
Cdd:PRK15402 183 GLWRAMPETAGR-VGEKLSLKelGRDYKLvlknRRFVAGALALGL 226
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
147-382 |
5.11e-04 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 41.81 E-value: 5.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 147 ALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAPLSL--------------TIPLYITAILPAIAWLVLWrtlpa 212
Cdd:cd17326 117 AYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYpgyvigiklrfnmyTAPAWLMAILGIINIILIL----- 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 213 tapqnirpstpLKFSDERLrrpMAIAFCAAFSVAIAQTTVGFVALDALDLAPNDAARVAGIALTLVGV---ALVISQSVL 289
Cdd:cd17326 192 -----------FFFKEVVC---IFLFFVVLFIFANLETIGTPLTMDMYGWTREEAVLYNGIILAVSGVlsvLVFLLFKFL 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 290 RKLQWPPQRLIRYGSLVAAIGFGSTalaqtswMIWASFAVAASGMGwiYP----SLSALAANSVNPGEQGMAAGTVASVQ 365
Cdd:cd17326 258 SLGLIDERKILLGGLILFFLGFVVT-------LPWGITGVILFGLG--YPignvMLYTLYSKILGPKPQGTMQGVLTASG 328
|
250
....*....|....*..
gi 1177840150 366 GAGVISGPLIGTLLYEA 382
Cdd:cd17326 329 SLARTLGPIFVTAIYTH 345
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
26-205 |
8.39e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.43 E-value: 8.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 26 LMPIMFAVFSGTMGIMAFVAIAGPLAR-TLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSYA 104
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYYFKyVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 105 ALCLFIDYSLSTLLAATLVFiglallrgivGAFYAAVPATSSALIADHIEP-------KKRASAMAAIGSASGAGMVIGP 177
Cdd:COG2211 310 LLFFLGPGNLWLLLVLAALA----------GIGLGAILVLPWAMLADVVDYdewktgrRREGLYFGIFTFAIKLGQALAG 379
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1177840150 178 GFVGLL------------APLSLTIPLYITAILPAIAWLV 205
Cdd:COG2211 380 ALAGLLlalfgyvagaaqSPSALTGIRLLFFLLPAVLLLL 419
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
26-208 |
8.59e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.06 E-value: 8.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 26 LMPIMFAVFSGTMGIMAFVAIAGPLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSYAa 105
Cdd:cd06173 211 RLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALL- 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 106 lclfidyslstLLAATLVFIGLALLRGIVGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAP 185
Cdd:cd06173 290 -----------VLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLAD 358
|
170 180
....*....|....*....|....
gi 1177840150 186 -LSLTIPLYITAILPAIAWLVLWR 208
Cdd:cd06173 359 aLGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
61-400 |
9.25e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.10 E-value: 9.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 61 IGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLrgVGGFTLSYAALCLFIDYSLSTLLAATLVFIGLALlrgivGAFYAA 140
Cdd:cd17355 40 ISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVML--LGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGA-----GTLAAV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 141 VPATSSALIADhiepKKRASAMAAIGSASGAGMVIG-PGFVGLLAPLSLTIPLYITAILPA---IAWLVLWRTLPATAPQ 216
Cdd:cd17355 113 AFATVAAWWFE----RRRGLALGILTAGGGLGSLVFlPLGAALIEAFGWRTALLVLALLALlvlVPVLLLLRRRPADLAL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 217 NIRPSTPLKFSDERLRRPM----------AIAFCAAFSVAIAQTTVGFVALDALdlapndAARVAGIALTLVGVALVISQ 286
Cdd:cd17355 189 RAYDDASPASPGSTLKEALrsasfwllalAFFLCGFAVVGLIVHLVPYLADRGI------SPAAAAVALALIGLFNIVGR 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 287 SVLRKLQ--WPPQRLIRYGSLVAAIGFGSTALAQTSWMIWASFAVA-ASGMGWIYPSLSALAANSVNPGEQGMAAGTVAS 363
Cdd:cd17355 263 LLSGWLGdrYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALfGLGWGATVPLTAALAARYFGARSYGTLFGLVFA 342
|
330 340 350
....*....|....*....|....*....|....*....
gi 1177840150 364 VQGAGVISGPLIGTLLYEA--GIGLPYLLVAALLFFGGL 400
Cdd:cd17355 343 PHQLGSALGPWLGGLLYDRtgSYTAAWALAVALGLIAAL 381
|
|
| PRK11646 |
PRK11646 |
multidrug efflux MFS transporter MdtH; |
272-403 |
9.48e-04 |
|
multidrug efflux MFS transporter MdtH;
Pssm-ID: 183255 Cd Length: 400 Bit Score: 41.20 E-value: 9.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 272 GIALTLVGVALVISQSVLRKL---------QWPPQRLIRYGSLVAAIGFGSTALAQTSWMIWASFAVAASGMGWIYPSLS 342
Cdd:PRK11646 42 GWAAVMVGIALGLRQFIQQGLgifggaiadRFGAKPMIVTGMLMRAAGFATMAIAHEPWLLWLSCILSGLGGTLFDPPRT 121
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1177840150 343 ALAANSVNPGEQGMAAGTVASVQGAGVISGPLIGTLLYEAGIGLPYLLVAALLFFGGLYAA 403
Cdd:PRK11646 122 ALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATGAVLFVLAAAFNA 182
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
23-202 |
1.14e-03 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 40.72 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 23 SLSLMPIMFAVFsgtmgiMAFVaIAGPLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLS 102
Cdd:cd17386 1 MLNVEPIVFLYM------FASV-LSGPVTQNFVYAANFYLYMNLMGSIPPLFSSLFLGSWSDRYGRKPPLLMSLVGLLLS 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 103 YAALCLFidySLSTLLAATLVFIGLALLRGIVGAFyAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVG- 181
Cdd:cd17386 74 SLILVLI---VYFTTVPSVWWFYLSAIPLALFGGF-TAFLSASFAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGh 149
|
170 180
....*....|....*....|.
gi 1177840150 182 LLAPLSLTIPLYITAILPAIA 202
Cdd:cd17386 150 LFKALGYAWSFSISAALLLIA 170
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
79-378 |
1.22e-03 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 40.83 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 79 WGGLSDKVGRRPVLLrgVGGFTLSYAALCLFIDYSLSTLLAATlvfiglallrgIVGAFYAAVPATSSALIADHIEPKKR 158
Cdd:TIGR00710 60 WGPLSDRYGRRPVLL--LGLFIFALSSLGLALSNNIETLLVLR-----------FVQAFGASAGSVISQALVRDIYPGEE 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 159 AS-AMAAIGSASGAGMVIGPGFVGLLAP-LSLTIPLYITAILPAIAWLVLWRTLPATAPQNIRPSTPLKFSD----ERLR 232
Cdd:TIGR00710 127 LSrIYSILMPVLALAPAVAPLLGGYILVwLSWHAIFAFLSLAGILLSALIFFILPETLPYEARIQISTYFETflllLKSK 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 233 RPMAIAFCAAFSVAIA---QTTVGFVALDALDLAPNdaarVAGIALTLVGVALVISQSVLRKL--QWPPQRLIRYGSLVA 307
Cdd:TIGR00710 207 MFWGYALIYGASFGGFfafFSGAPFVYIDIMGVSPS----VFGLLFALNIIAMIFGGFLNGRFikKWGAKSLLRMGLILF 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 308 AIGFGSTALA-----QTSWMIWASFAVAASGMGWIYPSLSALAANsvnpgEQGMAAGTVASVQGA-----GVISGPLIGT 377
Cdd:TIGR00710 283 AVSAVLLEITailglGSWAMIIGPMMFVGIGNSMISSIAMAYALE-----DFPHVAGTASALFGTlrlvlGAIVGYLVSL 357
|
.
gi 1177840150 378 L 378
Cdd:TIGR00710 358 I 358
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
80-223 |
2.18e-03 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 40.19 E-value: 2.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 80 GGLSDKVGRRPVLLRGVGGFTLSYAALcLFIDySLSTLLAATLVfiglallRGIVGAFYAAVPATSsalIADHIEPKKRA 159
Cdd:PRK15403 72 GPLSDRIGRRPVLITGALIFTLACAAT-LFTT-SMTQFLIARFI-------QGTSICFIATVGYVT---VQEAFGQTKGI 139
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1177840150 160 SAMAAIGSASGAGMVIGP-GFVGLLAPLSLTIPLYITAILPAIAWLVLWRTLPATAPQNIRPSTP 223
Cdd:PRK15403 140 KLMAIITSIVLVAPIIGPlSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKRGAVPFSA 204
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
24-379 |
2.34e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.87 E-value: 2.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 24 LSLMPIMFAvFSGTMGIMAFVAIAGPLARTLALEPWHIGAAMTVGGFTWVICARwwggLSDKVGRRPVLLrgvggftlsy 103
Cdd:cd17504 1 LALAALAVM-LVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGR----LGDLYGRKKVLL---------- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 104 aaLCLFIdYSLSTLLAATLV-FIGLALLRGIVGAFYAAVPaTSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGL 182
Cdd:cd17504 66 --IVLAI-YTAGSLLAAFAPnLPVLIAGRALQGIGGAVFP-LAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGW 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 183 LAPLSLTIPLYITAILPAIAWLVLwrtlpatapqnirpsTPLKFSDERLRRPMAIAFCAAF--SVAIAQTTVGFVAL--D 258
Cdd:cd17504 142 IVQHLGWRWIFWTAAPVAVLLAAL---------------VPLIDLRLLRRRNVLLANITALlaGFGMFMVFQLLPQLlqL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 259 ALDLAPNDAARVAGIALTLVGVALVISQSVLRKL--QWPPQRLIRYGSLVAAIGFGSTAL-AQTSWMIWASFAVAASGMG 335
Cdd:cd17504 207 PTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLiaRVGPRRVLLIGLVISAVGLLLLALlHSSLWALVVALLLIGIGLG 286
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1177840150 336 WIYPSLSALAANSVNPGEQGMAAGTVASVQGAGVISGPLIGTLL 379
Cdd:cd17504 287 LAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
80-163 |
2.89e-03 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 39.65 E-value: 2.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 80 GGLSDKVGRRPVLLRGVGGFTLsyAALCLFIDYSLSTLLAatlVFIGLALLRGIVGAFYAAVPATSSALIADHIepkkRA 159
Cdd:cd17366 250 GRLSDRVGRKPVYAAGLAGLLV--LAVPAFLLMNSGSIAA---IFIGLLVLGLLLSCYTATMASTLPALFPTHV----RY 320
|
....
gi 1177840150 160 SAMA 163
Cdd:cd17366 321 SALA 324
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
41-239 |
4.53e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 38.82 E-value: 4.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 41 MAFVAIAGPLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSyaalclfidyslSTLLAA 120
Cdd:cd17371 16 LLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVF------------TLLCGF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 121 TLVFIGLALLRGIVGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAPLSLTI----PLYITA 196
Cdd:cd17371 84 AQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEiawrVLFLLG 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1177840150 197 ILPAIAWLVLWRTLP----ATAPQNIRPSTPLKFS-----DERLRRPMAIAF 239
Cdd:cd17371 164 ALPALLVLFIRRFVKeppqWQAARAARRHFADRPSlrelfSPPLLRTTLLAS 215
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
79-207 |
4.78e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 38.75 E-value: 4.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 79 WGGLSDKVGRRPVLLrgvggftlsyaALCLFIDYSLSTLLAATLVFIGLALLRGIVGAFYAAVPATSSALIADHIEPKKR 158
Cdd:cd17353 269 WGWLSDKIGRKNTLS-----------IAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNA 337
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1177840150 159 ASAMAAIGSASGAGMVIGPG-FVGLLAPLSLTIPLYITAILPAIAWLVLW 207
Cdd:cd17353 338 GTNYGLLYTAKGVGGLIGPIiAAYVLYTGGYNAAFIIAAALSLVALALAL 387
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
32-375 |
4.92e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 38.76 E-value: 4.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 32 AVFSGTMGIMAFVAIA--GPLART-LALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGFTLSYAALCL 108
Cdd:cd17475 1 ATLAQAAASLVAQGIPalAPFLQEdLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 109 FIDYslstllaaTLVFIGLALlrgiVGAFYAAVPATSSALIADHIEPKKRASAM------AAIGSASGAgmVIGPGFVGL 182
Cdd:cd17475 81 VGSY--------PVLLVLLFL----VGAGYGSVQPGGGRAIMRWFPPRERGLAMgirqtgVPLGGALAA--ALLPPLALH 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 183 LAPLSLTIPLYITAILPAIAWLVLWRTLPATAPQNIRPSTPLKFSDERLR-RPMAIAFCAAFSVAIAQTTVGFVALDALD 261
Cdd:cd17475 147 YGWRAAFVVAGLVSILAAVLFWLFYREPPAASAATESASTLLRSLKEVLRnRDVWLIAIAGALLVAPQFALLTFLLLFLH 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 262 lapndaaRVAGIALTLVGVALVISQ---SVLRKL-------QWPPQRLIRYG--SLVAAIGFGSTALAQTSWMIWASFAV 329
Cdd:cd17475 227 -------DHLGLSVVAAGALLAVAQlggALGRIGlgrvsdrVFGGRRRPVLVitAAIAAAALLVLSLLSPGTPLWLLVLL 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1177840150 330 AA----SGMGWIYPSLsALAANSVNPGEQGMAAGTVASVQGAGVISGPLI 375
Cdd:cd17475 300 LIllglFAIGWNGLYL-TLVAESAGPEQAGTALGLANTINFIGIAIGPPL 348
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
31-208 |
6.15e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 38.60 E-value: 6.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 31 FAVFS-GTMGIMAFVAIAGplARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGVGGftlsYAALCLF 109
Cdd:COG2270 247 YFFYRdGVQTVIAFAGIYA--AGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVI----WIVVCLA 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 110 IdYSLSTllaaTLVFIGLALLrgiVGAFYAAVPATSSALIADHIEPKKRASAMAAIGSASGAGMVIGPGFVGLLAPLSLT 189
Cdd:COG2270 321 A-YFLTT----ALAFWILGLL---IGLVMGGIQALSRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGS 392
|
170 180
....*....|....*....|.
gi 1177840150 190 IPLYITAILP--AIAWLVLWR 208
Cdd:COG2270 393 QRLGILSLIVffVIGLVLLLR 413
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
79-211 |
8.34e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 37.99 E-value: 8.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 79 WGGLSDKVGRRPVLLRGVGGFTLSyAALCLFIDYslstllaatlvFIGLALLRGIVGAFYAAVPATSSALIADHIEPKKR 158
Cdd:cd17328 54 FGYLGDRYNRKWILAVGILIWSAA-TLLSSFAPN-----------FWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKR 121
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1177840150 159 ASAMA----AIGSASGAGMVIGpGFVGLLApLSLTIPLYITAILPAIAWLVLWRTLP 211
Cdd:cd17328 122 TRALGvfyfAIPLGSGLGYVVG-GLVAQAT-GGWRWAFRVTGVLGVLLAILLLLFVR 176
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
235-402 |
9.44e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 37.93 E-value: 9.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 235 MAIAFCAAFSVAIAQTTVGFVAL---DALDLAPNDAARVAGIALTLVGVALVISQSVLRKlqWPPQRLIRYGSLVAAIGF 311
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPplqADLGLSAAQLGLLASAFFLGYALGQIPAGLLADR--FGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 312 GSTALAQTSWMIWASFAVAASGMGWIYPSLSALAANSVNPGEQGMAAGTVASVQGAGVISGPLIGTLLYEA-GIGLPYLL 390
Cdd:COG2271 90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAfGWRAAFLI 169
|
170
....*....|..
gi 1177840150 391 VAALLFFGGLYA 402
Cdd:COG2271 170 LGLPGLLLALLR 181
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
17-123 |
9.95e-03 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 37.96 E-value: 9.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177840150 17 KQESPPSLSLMPIMFAVfsGTMGIMAFVAIAGPLARTLALEPWHIGAAMTVGGFTWVICARWWGGLSDKVGRRPVLLRGV 96
Cdd:PRK11652 3 RQRNVNLLFMLVLLVAV--GQMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGM 80
|
90 100
....*....|....*....|....*..
gi 1177840150 97 GGFTLsyAALCLFIDYSLSTLLAATLV 123
Cdd:PRK11652 81 SIFIL--GTLVALFAHSLTVLIAASAI 105
|
|
| |
