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Conserved domains on  [gi|1178526592|ref|WP_083045648|]
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redoxin domain-containing protein [Mycolicibacterium monacense]

Protein Classification

TlpA family protein disulfide reductase( domain architecture ID 10001660)

TlpA family protein disulfide reductase such as Bradyrhizobium japonicum thiol:disulfide interchange protein TlpA, an unusual thioredoxin which has been implicated in the biogenesis of cytochrome aa3 and also characterized as a reductant for the copper metallochaperone ScoI, and similar to ResA and DsbE, which are essential proteins in cytochrome c maturation

CATH:  3.40.30.10
Gene Ontology:  GO:0016491
PubMed:  11531338|15667290

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrxA COG0526
Thiol-disulfide isomerase or thioredoxin [Posttranslational modification, protein turnover, ...
 57-178 1.02e-07

Thiol-disulfide isomerase or thioredoxin [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440292 [Multi-domain]  Cd Length: 139  Bit Score: 48.92  E-value: 1.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178526592  57 VDGKTVELPAAA--PTAILFFSYGCGECVgggKSLAAARAAVEEAGGsAKFLAVDIvpTEKPADVRHFLDQIGGTsLPAV 134
Cdd:COG0526    16 LDGKPLSLADLKgkPVLVNFWATWCPPCR---AEMPVLKELAEEYGG-VVFVGVDV--DENPEAVKAFLKELGLP-YPVL 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1178526592 135 VDTNGALTSRYQVTA-PTTaLVIDPSGQISYR--GhAPSQDQILAAL 178
Cdd:COG0526    89 LDPDGELAKAYGVRGiPTT-VLIDKDGKIVARhvG-PLSPEELEEAL 133
 
Name Accession Description Interval E-value
TrxA COG0526
Thiol-disulfide isomerase or thioredoxin [Posttranslational modification, protein turnover, ...
 57-178 1.02e-07

Thiol-disulfide isomerase or thioredoxin [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440292 [Multi-domain]  Cd Length: 139  Bit Score: 48.92  E-value: 1.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178526592  57 VDGKTVELPAAA--PTAILFFSYGCGECVgggKSLAAARAAVEEAGGsAKFLAVDIvpTEKPADVRHFLDQIGGTsLPAV 134
Cdd:COG0526    16 LDGKPLSLADLKgkPVLVNFWATWCPPCR---AEMPVLKELAEEYGG-VVFVGVDV--DENPEAVKAFLKELGLP-YPVL 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1178526592 135 VDTNGALTSRYQVTA-PTTaLVIDPSGQISYR--GhAPSQDQILAAL 178
Cdd:COG0526    89 LDPDGELAKAYGVRGiPTT-VLIDKDGKIVARhvG-PLSPEELEEAL 133
TlpA_like_family cd02966
TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are ...
 57-165 1.97e-07

TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.


Pssm-ID: 239264 [Multi-domain]  Cd Length: 116  Bit Score: 47.62  E-value: 1.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178526592  57 VDGKTVELPAAAPTAIL--FFSYGCGECVGGGKSLAAARAAVEEAGgsAKFLAVDiVPTEKPADVRHFLDQIGgTSLPAV 134
Cdd:cd02966     7 LDGKPVSLSDLKGKVVLvnFWASWCPPCRAEMPELEALAKEYKDDG--VEVVGVN-VDDDDPAAVKAFLKKYG-ITFPVL 82

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1178526592 135 VDTNGALTSRYQVTA-PTTaLVIDPSGQISYR 165
Cdd:cd02966    83 LDPDGELAKAYGVRGlPTT-FLIDRDGRIRAR 113
 
Name Accession Description Interval E-value
TrxA COG0526
Thiol-disulfide isomerase or thioredoxin [Posttranslational modification, protein turnover, ...
 57-178 1.02e-07

Thiol-disulfide isomerase or thioredoxin [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440292 [Multi-domain]  Cd Length: 139  Bit Score: 48.92  E-value: 1.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178526592  57 VDGKTVELPAAA--PTAILFFSYGCGECVgggKSLAAARAAVEEAGGsAKFLAVDIvpTEKPADVRHFLDQIGGTsLPAV 134
Cdd:COG0526    16 LDGKPLSLADLKgkPVLVNFWATWCPPCR---AEMPVLKELAEEYGG-VVFVGVDV--DENPEAVKAFLKELGLP-YPVL 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1178526592 135 VDTNGALTSRYQVTA-PTTaLVIDPSGQISYR--GhAPSQDQILAAL 178
Cdd:COG0526    89 LDPDGELAKAYGVRGiPTT-VLIDKDGKIVARhvG-PLSPEELEEAL 133
TlpA_like_family cd02966
TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are ...
 57-165 1.97e-07

TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.


Pssm-ID: 239264 [Multi-domain]  Cd Length: 116  Bit Score: 47.62  E-value: 1.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178526592  57 VDGKTVELPAAAPTAIL--FFSYGCGECVGGGKSLAAARAAVEEAGgsAKFLAVDiVPTEKPADVRHFLDQIGgTSLPAV 134
Cdd:cd02966     7 LDGKPVSLSDLKGKVVLvnFWASWCPPCRAEMPELEALAKEYKDDG--VEVVGVN-VDDDDPAAVKAFLKKYG-ITFPVL 82

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1178526592 135 VDTNGALTSRYQVTA-PTTaLVIDPSGQISYR 165
Cdd:cd02966    83 LDPDGELAKAYGVRGlPTT-FLIDRDGRIRAR 113
Bcp COG1225
Peroxiredoxin [Posttranslational modification, protein turnover, chaperones];
57-178 3.47e-05

Peroxiredoxin [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440838 [Multi-domain]  Cd Length: 136  Bit Score: 41.77  E-value: 3.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1178526592  57 VDGKTVELPAAA--PTAILFFSYGCGECVGGGKSLAAARAAVEEAGgsAKFLAVDivpTEKPADVRHFLDQIGGTsLPAV 134
Cdd:COG1225     9 LDGKTVSLSDLRgkPVVLYFYATWCPGCTAELPELRDLYEEFKDKG--VEVLGVS---SDSDEAHKKFAEKYGLP-FPLL 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1178526592 135 VDTNGALTSRYQVTA-PTTaLVIDPSGQISYR-----GHAPSQDQILAAL 178
Cdd:COG1225    83 SDPDGEVAKAYGVRGtPTT-FLIDPDGKIRYVwvgpvDPRPHLEEVLEAL 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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