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Conserved domains on  [gi|1199425969|ref|WP_087166482|]
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DDE-type integrase/transposase/recombinase [Lachnoclostridium sp. An131]

Protein Classification

transposase( domain architecture ID 11462356)

transposase binds to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rve COG3316
Transposase (or an inactivated derivative), DDE domain [Mobilome: prophages, transposons];
215-472 1.67e-62

Transposase (or an inactivated derivative), DDE domain [Mobilome: prophages, transposons];


:

Pssm-ID: 442545 [Multi-domain]  Cd Length: 235  Bit Score: 203.21  E-value: 1.67e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 215 SSLKFSRHNAHVMGLCLTLHVNLGLSLRKTSQALkDLYNIRISHQQVANYARTAALVIKPFVDNYEYKTGTTFIADETYI 294
Cdd:COG3316     2 VDFKGRRFPPEIILLAVRLYLRYGLSLRDVEEML-AERGVDVSHSTIYRWVQKFAPLIAKRLRRRRPPLSDSWHVDETYI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 295 KVRGIKGYIWFIMDAVSRsILGYQVSDNRGVGPCILAMRMAFRKLKQLPEnfRFIADGYSAYPLAAQQFFHQFGEnfRFD 374
Cdd:COG3316    81 KIKGKWHYLYRAVDAEGR-ILDFLLSPRRDTKAAKRFLRKALKKYGLKPR--VIVTDKLPSYGAALRELKPEGGL--GVE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 375 ITQVIGLTNedevskefrpfkqMIERLNRTFKASYRITCGYDNYEGANYNVALWVAYYNFLRPHQHnhyrvLNKAEHLEN 454
Cdd:COG3316   156 HRQVKGLNN-------------RIERDHRTLKRRERPMRGFKSFRTAQRFLSGFEAYYNFRRPHRS-----LNGATPARV 217

                         250
                  ....*....|....*...
gi 1199425969 455 ADNMPGKWQLLIFLGQQT 472
Cdd:COG3316   218 ARAAASKWGELILLAAAF 235
PRK07219 super family cl35562
DNA topoisomerase I; Validated
 80-176 2.21e-03

DNA topoisomerase I; Validated


The actual alignment was detected with superfamily member PRK07219:

Pssm-ID: 235971 [Multi-domain]  Cd Length: 822  Bit Score: 40.75  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969  80 CPIKRQSECDIPEECSCPRCQApkpYLYKNNGSKGQ-LSC-KVCDAKFSQQDNRFSAIKL---RCPHCGNTLVPKKDRKF 154
Cdd:PRK07219  675 CEAEKEEEDPDEVIGPCPKCGG---ELAIKQLKYGSfLGCtNYPKCKYTLPLPRRGKITVtdeKCPECGLPLLRVKGGFG 751

                          90       100
                  ....*....|....*....|..
gi 1199425969 155 FVLHKCVNPKCPYYLHNLKKVE 176
Cdd:PRK07219  752 DELGCCNNPKCNYTEKQKKEKE 773
 
Name Accession Description Interval E-value
Rve COG3316
Transposase (or an inactivated derivative), DDE domain [Mobilome: prophages, transposons];
215-472 1.67e-62

Transposase (or an inactivated derivative), DDE domain [Mobilome: prophages, transposons];


Pssm-ID: 442545 [Multi-domain]  Cd Length: 235  Bit Score: 203.21  E-value: 1.67e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 215 SSLKFSRHNAHVMGLCLTLHVNLGLSLRKTSQALkDLYNIRISHQQVANYARTAALVIKPFVDNYEYKTGTTFIADETYI 294
Cdd:COG3316     2 VDFKGRRFPPEIILLAVRLYLRYGLSLRDVEEML-AERGVDVSHSTIYRWVQKFAPLIAKRLRRRRPPLSDSWHVDETYI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 295 KVRGIKGYIWFIMDAVSRsILGYQVSDNRGVGPCILAMRMAFRKLKQLPEnfRFIADGYSAYPLAAQQFFHQFGEnfRFD 374
Cdd:COG3316    81 KIKGKWHYLYRAVDAEGR-ILDFLLSPRRDTKAAKRFLRKALKKYGLKPR--VIVTDKLPSYGAALRELKPEGGL--GVE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 375 ITQVIGLTNedevskefrpfkqMIERLNRTFKASYRITCGYDNYEGANYNVALWVAYYNFLRPHQHnhyrvLNKAEHLEN 454
Cdd:COG3316   156 HRQVKGLNN-------------RIERDHRTLKRRERPMRGFKSFRTAQRFLSGFEAYYNFRRPHRS-----LNGATPARV 217

                         250
                  ....*....|....*...
gi 1199425969 455 ADNMPGKWQLLIFLGQQT 472
Cdd:COG3316   218 ARAAASKWGELILLAAAF 235
transpos_IS6 NF033587
IS6 family transposase;
221-436 6.74e-18

IS6 family transposase;


Pssm-ID: 411209 [Multi-domain]  Cd Length: 203  Bit Score: 81.85  E-value: 6.74e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 221 RHNAHVMGLCLTLHVNLGLSLRKTSQALKDLyNIRISHQQVANYARTAALVIKPFVDNYEYKTGTTFIADETYIKVRGIK 300
Cdd:NF033587    5 RFPPEIILLAVRLYLRGPLSLRDVEEILAER-GVSVSHSTIYRWVHKYAPQLAKRLRRRKPRPPDSWAVDETVIKINGKW 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 301 GYIWFIMDAVSRsILGYQVSDNRGVGPCILAMRMAFRKLKQLPEnfRFIADGYSAYPLAaqqfFHQFGENFRFDITQVIG 380
Cdd:NF033587   84 YYLYRAVDKEGE-TLDFLLSPRRDTDAAKRFLRKLLKKHDGSPR--VILTDKAPSYPAA----LRRLGLEGRLPRRIEHR 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1199425969 381 LTNedevskefrPFKQMIERLNRTFKASYRITCGYDNYEGANYNVALWVAYYNFLR 436
Cdd:NF033587  157 QRK---------YLNNLIEQDHRRTKRFINSMLGFKSFRTARRTLAGFEAMYNLRK 203
DDE_Tnp_IS240 pfam13610
DDE domain; This DDE domain is found in a wide variety of transposases including those found ...
 289-438 1.03e-08

DDE domain; This DDE domain is found in a wide variety of transposases including those found in IS240, IS26, IS6100 and IS26.


Pssm-ID: 433347 [Multi-domain]  Cd Length: 138  Bit Score: 53.91  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 289 ADETYIKVRGIKGYIWFIMDAVSRsILGYQVSDNRGVGPCILAMRMAFRKLKQLPEnfRFIADGYSAYPLAAQQFFHQFG 368
Cdd:pfam13610   5 VDETYVKVKGKWHYVYRAVDKEGN-TLDFYVSKRRDTDAAKAFLRRALKNYKGRPE--EIVTDKAGAYLSAIKELKPSGL 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 369 ENFRFDITQVIGLTNEDEvsKEFRPFKQMIeRLNRTFKasyritcgydNYEGANYNVALWVAYYNFLRPH 438
Cdd:pfam13610  82 LLDDIRHVTVKYLNNRIE--SDHRPLKKRL-RPMRGFK----------SFKSARKTIAGFEVVHNLRKGH 138
PHA02517 PHA02517
putative transposase OrfB; Reviewed
 287-450 6.31e-08

putative transposase OrfB; Reviewed


Pssm-ID: 222853 [Multi-domain]  Cd Length: 277  Bit Score: 54.10  E-value: 6.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 287 FIADETYIKVRGIKGYIWFIMDAVSRSILGYQVSDNRGVGPCILAMRMAFrKLKQLPENFRFIADGYSAYplAAQQFFHQ 366
Cdd:PHA02517  113 WVADFTYVSTWQGWVYVAFIIDVFARRIVGWRVSSSMDTDFVLDALEQAL-WARGRPGGLIHHSDKGSQY--VSLAYTQR 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 367 FGEnfrfditqvigLTNEDEVSKEFRPFKQ-MIERLNRTFKASYRITCGYDNYEGANYNVALWVAYYNFLRPHQHNHYRV 445
Cdd:PHA02517  190 LKE-----------AGIRASTGSRGDSYDNaPAESINGLYKAEVIHRVSWKNREEVELATLEWVAWYNNRRLHERLGYTP 258


                  ....*
gi 1199425969 446 LNKAE 450
Cdd:PHA02517  259 PAEAE 263
transpos_IS66 NF033517
IS66 family transposase; Members of this protein family are DDE transposases from the IS66 ...
 224-356 2.95e-05

IS66 family transposase; Members of this protein family are DDE transposases from the IS66 family insertion sequences, which typically consist of two accessary genes (TnpA and TnpB) and the third gene encoding the transposase.


Pssm-ID: 468053 [Multi-domain]  Cd Length: 388  Bit Score: 46.04  E-value: 2.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 224 AHVMglclTLHVNLGLSLRKTSQALKDLYNIRISHQQVANYARTAALVIKPFVD-NYEY-KTGTTFIADETYIKV----R 297
Cdd:NF033517   93 AHVA----VLKYADHLPLYRQQQILARLFGIELSRGTLANWVGRAAELLEPLYDaLKEElLAAPVLHADETGVPVlepgR 168

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1199425969 298 GIKGYIWfimdAVSRS--ILGYQVSDNRGvGPCILAMRMAFR-KLkqlpenfrfIADGYSAY 356
Cdd:NF033517  169 GKTGWLW----VYASAppAVLFDYAPSRG-GEVPEALLEGFNgVL---------QSDGYAGY 216
PRK07219 PRK07219
DNA topoisomerase I; Validated
 80-176 2.21e-03

DNA topoisomerase I; Validated


Pssm-ID: 235971 [Multi-domain]  Cd Length: 822  Bit Score: 40.75  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969  80 CPIKRQSECDIPEECSCPRCQApkpYLYKNNGSKGQ-LSC-KVCDAKFSQQDNRFSAIKL---RCPHCGNTLVPKKDRKF 154
Cdd:PRK07219  675 CEAEKEEEDPDEVIGPCPKCGG---ELAIKQLKYGSfLGCtNYPKCKYTLPLPRRGKITVtdeKCPECGLPLLRVKGGFG 751

                          90       100
                  ....*....|....*....|..
gi 1199425969 155 FVLHKCVNPKCPYYLHNLKKVE 176
Cdd:PRK07219  752 DELGCCNNPKCNYTEKQKKEKE 773
YrdD COG0551
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ...
 65-176 3.41e-03

DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];


Pssm-ID: 440317 [Multi-domain]  Cd Length: 695  Bit Score: 39.85  E-value: 3.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969  65 KELIPYFHKRYGKKICPIKRQSECDIPEECSCPRCQapKPYLYKNnGSKGQ-LSCK---VCdaKFSQQDNRFSAIKLRCP 140
Cdd:COG0551   558 EEYPFFKKLLEIAEEEGEEELSEEDEVLGEKCPKCG--KPLVIKK-GRYGKfLGCSnypEC--KYTKPLPKPEVTGVKCP 632

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1199425969 141 HCGNTLVPKKDRKFFVLHKCVN-PKCPYYLhNLKKVE 176
Cdd:COG0551   633 KCGKKLVLRKSKKGKVFYGCSNyPKCKFTE-WDKPVK 668
transpos_IS481 NF033577
IS481 family transposase; null
 397-439 7.21e-03

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 38.34  E-value: 7.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1199425969 397 MIERLNRTFKASYRITCGYDNYEGANYNVALWVAYYNFLRPHQ 439
Cdd:NF033577  230 KVERFHRTLKDEFAYARPYESLAELQAALDEWLHHYNHHRPHS 272
 
Name Accession Description Interval E-value
Rve COG3316
Transposase (or an inactivated derivative), DDE domain [Mobilome: prophages, transposons];
215-472 1.67e-62

Transposase (or an inactivated derivative), DDE domain [Mobilome: prophages, transposons];


Pssm-ID: 442545 [Multi-domain]  Cd Length: 235  Bit Score: 203.21  E-value: 1.67e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 215 SSLKFSRHNAHVMGLCLTLHVNLGLSLRKTSQALkDLYNIRISHQQVANYARTAALVIKPFVDNYEYKTGTTFIADETYI 294
Cdd:COG3316     2 VDFKGRRFPPEIILLAVRLYLRYGLSLRDVEEML-AERGVDVSHSTIYRWVQKFAPLIAKRLRRRRPPLSDSWHVDETYI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 295 KVRGIKGYIWFIMDAVSRsILGYQVSDNRGVGPCILAMRMAFRKLKQLPEnfRFIADGYSAYPLAAQQFFHQFGEnfRFD 374
Cdd:COG3316    81 KIKGKWHYLYRAVDAEGR-ILDFLLSPRRDTKAAKRFLRKALKKYGLKPR--VIVTDKLPSYGAALRELKPEGGL--GVE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 375 ITQVIGLTNedevskefrpfkqMIERLNRTFKASYRITCGYDNYEGANYNVALWVAYYNFLRPHQHnhyrvLNKAEHLEN 454
Cdd:COG3316   156 HRQVKGLNN-------------RIERDHRTLKRRERPMRGFKSFRTAQRFLSGFEAYYNFRRPHRS-----LNGATPARV 217

                         250
                  ....*....|....*...
gi 1199425969 455 ADNMPGKWQLLIFLGQQT 472
Cdd:COG3316   218 ARAAASKWGELILLAAAF 235
transpos_IS6 NF033587
IS6 family transposase;
221-436 6.74e-18

IS6 family transposase;


Pssm-ID: 411209 [Multi-domain]  Cd Length: 203  Bit Score: 81.85  E-value: 6.74e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 221 RHNAHVMGLCLTLHVNLGLSLRKTSQALKDLyNIRISHQQVANYARTAALVIKPFVDNYEYKTGTTFIADETYIKVRGIK 300
Cdd:NF033587    5 RFPPEIILLAVRLYLRGPLSLRDVEEILAER-GVSVSHSTIYRWVHKYAPQLAKRLRRRKPRPPDSWAVDETVIKINGKW 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 301 GYIWFIMDAVSRsILGYQVSDNRGVGPCILAMRMAFRKLKQLPEnfRFIADGYSAYPLAaqqfFHQFGENFRFDITQVIG 380
Cdd:NF033587   84 YYLYRAVDKEGE-TLDFLLSPRRDTDAAKRFLRKLLKKHDGSPR--VILTDKAPSYPAA----LRRLGLEGRLPRRIEHR 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1199425969 381 LTNedevskefrPFKQMIERLNRTFKASYRITCGYDNYEGANYNVALWVAYYNFLR 436
Cdd:NF033587  157 QRK---------YLNNLIEQDHRRTKRFINSMLGFKSFRTARRTLAGFEAMYNLRK 203
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
289-444 8.86e-10

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 59.78  E-value: 8.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 289 ADETYIKVRGIKGYIWFIMDAVSRSILGYQVSDNRGVGPCILAMRMAFRKLKQ-LPENFR------FIADGYsayplaaQ 361
Cdd:COG2801   154 TDITYIPTAEGWLYLAAVIDLFSREIVGWSVSDSMDAELVVDALEMAIERRGPpKPLILHsdngsqYTSKAY-------Q 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 362 QFFHQFGenfrfdITQVIGltnedevskefRPFK----QMIERLNRTFKASYRITCGYDNYEGANYNVALWVAYYNFLRP 437
Cdd:COG2801   227 ELLKKLG------ITQSMS-----------RPGNpqdnAFIESFFGTLKYELLYRRRFESLEEAREAIEEYIEFYNHERP 289


                  ....*..
gi 1199425969 438 HQHNHYR 444
Cdd:COG2801   290 HSSLGYL 296
DDE_Tnp_IS240 pfam13610
DDE domain; This DDE domain is found in a wide variety of transposases including those found ...
 289-438 1.03e-08

DDE domain; This DDE domain is found in a wide variety of transposases including those found in IS240, IS26, IS6100 and IS26.


Pssm-ID: 433347 [Multi-domain]  Cd Length: 138  Bit Score: 53.91  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 289 ADETYIKVRGIKGYIWFIMDAVSRsILGYQVSDNRGVGPCILAMRMAFRKLKQLPEnfRFIADGYSAYPLAAQQFFHQFG 368
Cdd:pfam13610   5 VDETYVKVKGKWHYVYRAVDKEGN-TLDFYVSKRRDTDAAKAFLRRALKNYKGRPE--EIVTDKAGAYLSAIKELKPSGL 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 369 ENFRFDITQVIGLTNEDEvsKEFRPFKQMIeRLNRTFKasyritcgydNYEGANYNVALWVAYYNFLRPH 438
Cdd:pfam13610  82 LLDDIRHVTVKYLNNRIE--SDHRPLKKRL-RPMRGFK----------SFKSARKTIAGFEVVHNLRKGH 138
PHA02517 PHA02517
putative transposase OrfB; Reviewed
 287-450 6.31e-08

putative transposase OrfB; Reviewed


Pssm-ID: 222853 [Multi-domain]  Cd Length: 277  Bit Score: 54.10  E-value: 6.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 287 FIADETYIKVRGIKGYIWFIMDAVSRSILGYQVSDNRGVGPCILAMRMAFrKLKQLPENFRFIADGYSAYplAAQQFFHQ 366
Cdd:PHA02517  113 WVADFTYVSTWQGWVYVAFIIDVFARRIVGWRVSSSMDTDFVLDALEQAL-WARGRPGGLIHHSDKGSQY--VSLAYTQR 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 367 FGEnfrfditqvigLTNEDEVSKEFRPFKQ-MIERLNRTFKASYRITCGYDNYEGANYNVALWVAYYNFLRPHQHNHYRV 445
Cdd:PHA02517  190 LKE-----------AGIRASTGSRGDSYDNaPAESINGLYKAEVIHRVSWKNREEVELATLEWVAWYNNRRLHERLGYTP 258


                  ....*
gi 1199425969 446 LNKAE 450
Cdd:PHA02517  259 PAEAE 263
DDE_Tnp_IS66 pfam03050
Transposase IS66 family; Transposase proteins are necessary for efficient DNA transposition. ...
 224-367 2.70e-05

Transposase IS66 family; Transposase proteins are necessary for efficient DNA transposition. This family includes IS66 from Agrobacterium tumefaciens.


Pssm-ID: 427113 [Multi-domain]  Cd Length: 281  Bit Score: 45.70  E-value: 2.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 224 AHVMglclTLHVNLGLSLRKTSQALKDLyNIRISHQQVANYARTAALVIKPFVDNYEYKTGTTFI--ADETYIKV----- 296
Cdd:pfam03050  10 ALIL----VLKYADHLPLYRQEDILARL-GVELSRGTLANWVGRAAELLEPLVDALRAALLESPVihADETPLRVlkpgr 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1199425969 297 -RGIKGYIW-FIMDAVSRSILGYQVSDNRGvGPCILAMRMAFRKlkqlpenfRFIADGYSAYP-LAAQQFFHQF 367
Cdd:pfam03050  85 gKGKKGWLWvYVTDDRPPPAVLFHYHPSRG-GEHPQALLGGFRG--------VLQTDGYAGYNkLARGQVTHAG 149
transpos_IS66 NF033517
IS66 family transposase; Members of this protein family are DDE transposases from the IS66 ...
 224-356 2.95e-05

IS66 family transposase; Members of this protein family are DDE transposases from the IS66 family insertion sequences, which typically consist of two accessary genes (TnpA and TnpB) and the third gene encoding the transposase.


Pssm-ID: 468053 [Multi-domain]  Cd Length: 388  Bit Score: 46.04  E-value: 2.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 224 AHVMglclTLHVNLGLSLRKTSQALKDLYNIRISHQQVANYARTAALVIKPFVD-NYEY-KTGTTFIADETYIKV----R 297
Cdd:NF033517   93 AHVA----VLKYADHLPLYRQQQILARLFGIELSRGTLANWVGRAAELLEPLYDaLKEElLAAPVLHADETGVPVlepgR 168

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1199425969 298 GIKGYIWfimdAVSRS--ILGYQVSDNRGvGPCILAMRMAFR-KLkqlpenfrfIADGYSAY 356
Cdd:NF033517  169 GKTGWLW----VYASAppAVLFDYAPSRG-GEVPEALLEGFNgVL---------QSDGYAGY 216
rve_3 pfam13683
Integrase core domain;
398-439 1.33e-04

Integrase core domain;


Pssm-ID: 433402 [Multi-domain]  Cd Length: 67  Bit Score: 39.89  E-value: 1.33e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1199425969 398 IERLNRTFKASYRITCGYDNYEGANYNVALWVAYYNFLRPHQ 439
Cdd:pfam13683  19 VESFNGTLRDECLNEHLFSSLAEARALLAAWREDYNTERPHS 60
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
 289-368 1.27e-03

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 38.06  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969 289 ADETYIKVRGIKGYIW--FIMDAVSRSILGYQVSDNRGVGPCILAMRMAFRKLKQLPEnfRFIADGYSAYPLAA-QQFFH 365
Cdd:pfam00665   7 GDFTYIRIPGGGGKLYllVIVDDFSREILAWALSSEMDAELVLDALERAIAFRGGVPL--IIHSDNGSEYTSKAfREFLK 84


                  ...
gi 1199425969 366 QFG 368
Cdd:pfam00665  85 DLG 87
PRK07219 PRK07219
DNA topoisomerase I; Validated
 80-176 2.21e-03

DNA topoisomerase I; Validated


Pssm-ID: 235971 [Multi-domain]  Cd Length: 822  Bit Score: 40.75  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969  80 CPIKRQSECDIPEECSCPRCQApkpYLYKNNGSKGQ-LSC-KVCDAKFSQQDNRFSAIKL---RCPHCGNTLVPKKDRKF 154
Cdd:PRK07219  675 CEAEKEEEDPDEVIGPCPKCGG---ELAIKQLKYGSfLGCtNYPKCKYTLPLPRRGKITVtdeKCPECGLPLLRVKGGFG 751

                          90       100
                  ....*....|....*....|..
gi 1199425969 155 FVLHKCVNPKCPYYLHNLKKVE 176
Cdd:PRK07219  752 DELGCCNNPKCNYTEKQKKEKE 773
YrdD COG0551
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ...
 65-176 3.41e-03

DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];


Pssm-ID: 440317 [Multi-domain]  Cd Length: 695  Bit Score: 39.85  E-value: 3.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199425969  65 KELIPYFHKRYGKKICPIKRQSECDIPEECSCPRCQapKPYLYKNnGSKGQ-LSCK---VCdaKFSQQDNRFSAIKLRCP 140
Cdd:COG0551   558 EEYPFFKKLLEIAEEEGEEELSEEDEVLGEKCPKCG--KPLVIKK-GRYGKfLGCSnypEC--KYTKPLPKPEVTGVKCP 632

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1199425969 141 HCGNTLVPKKDRKFFVLHKCVN-PKCPYYLhNLKKVE 176
Cdd:COG0551   633 KCGKKLVLRKSKKGKVFYGCSNyPKCKFTE-WDKPVK 668
transpos_IS481 NF033577
IS481 family transposase; null
 397-439 7.21e-03

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 38.34  E-value: 7.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1199425969 397 MIERLNRTFKASYRITCGYDNYEGANYNVALWVAYYNFLRPHQ 439
Cdd:NF033577  230 KVERFHRTLKDEFAYARPYESLAELQAALDEWLHHYNHHRPHS 272
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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