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Conserved domains on  [gi|1221648894|ref|WP_089777329|]
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MULTISPECIES: type II methionyl aminopeptidase [Haloferax]

Protein Classification

MetAP2 domain-containing protein( domain architecture ID 10099546)

MetAP2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MetAP2 cd01088
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 12-296 1.43e-130

Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


:

Pssm-ID: 238521 [Multi-domain]  Cd Length: 291  Bit Score: 372.35  E-value: 1.43e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  12 EKYREAGEVLRTVLDESAEMVEPGVTHLEVAEHAEARIRELADGCAFPVNISVNEEASHASPGRDDDTVFGE-DMVCLDV 90
Cdd:cd01088     2 EKYREAGEIHRQVRKYAQSLIKPGMTLLEIAEFVENRIRELGAGPAFPVNLSINECAAHYTPNAGDDTVLKEgDVVKLDF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  91 GVHVDGYIADSAVTVDLSGN-DELVESAEEALDAALDMVEAGAHTGKIGAEIEDVIRGYGYTPVLNLSGHGVEQWDAHTD 169
Cdd:cd01088    82 GAHVDGYIADSAFTVDFDPKyDDLLEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIESYGFKPIRNLTGHSIERYRLHAG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894 170 PTIPNRGADRGVELEVGDVVAIEPFATDGTGKVSEGSKNEIYSLVNDRSVRDRMSRKLLDEVREKYKLLPFAARWFEG-- 247
Cdd:cd01088   162 KSIPNVKGGEGTRLEEGDVYAIEPFATTGKGYVHDGPECSIYMLNRDKPLRLPRARKLLDVIYENFGTLPFARRWLDRlg 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1221648894 248 -GRSEMAIRRLEQQGILRGYPVLKEEDGALVGQAEDTIIVTEDGYENLTR 296
Cdd:cd01088   242 eTKLLMALKNLCKAGIVYPYPVLKEISGGYVAQFEHTIIVREDGKEVTTR 291
 
Name Accession Description Interval E-value
MetAP2 cd01088
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 12-296 1.43e-130

Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238521 [Multi-domain]  Cd Length: 291  Bit Score: 372.35  E-value: 1.43e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  12 EKYREAGEVLRTVLDESAEMVEPGVTHLEVAEHAEARIRELADGCAFPVNISVNEEASHASPGRDDDTVFGE-DMVCLDV 90
Cdd:cd01088     2 EKYREAGEIHRQVRKYAQSLIKPGMTLLEIAEFVENRIRELGAGPAFPVNLSINECAAHYTPNAGDDTVLKEgDVVKLDF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  91 GVHVDGYIADSAVTVDLSGN-DELVESAEEALDAALDMVEAGAHTGKIGAEIEDVIRGYGYTPVLNLSGHGVEQWDAHTD 169
Cdd:cd01088    82 GAHVDGYIADSAFTVDFDPKyDDLLEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIESYGFKPIRNLTGHSIERYRLHAG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894 170 PTIPNRGADRGVELEVGDVVAIEPFATDGTGKVSEGSKNEIYSLVNDRSVRDRMSRKLLDEVREKYKLLPFAARWFEG-- 247
Cdd:cd01088   162 KSIPNVKGGEGTRLEEGDVYAIEPFATTGKGYVHDGPECSIYMLNRDKPLRLPRARKLLDVIYENFGTLPFARRWLDRlg 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1221648894 248 -GRSEMAIRRLEQQGILRGYPVLKEEDGALVGQAEDTIIVTEDGYENLTR 296
Cdd:cd01088   242 eTKLLMALKNLCKAGIVYPYPVLKEISGGYVAQFEHTIIVREDGKEVTTR 291
met_pdase_II TIGR00501
methionine aminopeptidase, type II; Methionine aminopeptidase (map) is a cobalt-binding enzyme. ...
 7-296 9.01e-104

methionine aminopeptidase, type II; Methionine aminopeptidase (map) is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. The role of this protein in general is to produce the mature amino end of cytosolic proteins by removing the N-terminal methionine. This model describes type II, among which the eukaryotic members typically have an N-terminal extension not present in archaeal members. It can act cotranslationally. The enzyme from rat has been shown to associate with translation initiation factor 2 (IF-2) and may have a role in translational regulation. [Protein fate, Protein modification and repair]


Pssm-ID: 129592  Cd Length: 295  Bit Score: 304.79  E-value: 9.01e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894   7 DDETVEKYREAGEVLRTVLDESAEMVEPGVTHLEVAEHAEARIRELADGCAFPVNISVNEEASHASPGRDDDTVFG-EDM 85
Cdd:TIGR00501   1 DIERAEKWIEAGKIHSKVRREAADRIVPGVKLLEVAEFVENRIRELGAEPAFPCNISINECAAHFTPKAGDKTVFKdGDV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  86 VCLDVGVHVDGYIADSAVTVDLSGN-DELVESAEEALDAALDMVEAGAHTGKIGAEIEDVIRGYGYTPVLNLSGHGVEQW 164
Cdd:TIGR00501  81 VKLDLGAHVDGYIADTAITVDLGDQyDNLVKAAKDALYTAIKEIRAGVRVGEIGKAIQEVIESYGVKPISNLTGHSMAPY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894 165 DAHTDPTIPNRGADRGVELEVGDVVAIEPFATDGTGKVSEGSKNEIYSLVNDRSVRDRMSRKLLDEVREKYKLLPFAARW 244
Cdd:TIGR00501 161 RLHGGKSIPNVKERDTTKLEEGDVVAIEPFATDGVGYVTDGGEVSIYAFLAERPVRLDSARNLLKTIDENYGTLPFARRW 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1221648894 245 FEGGRSE---MAIRRLEQQGILRGYPVLKEEDGALVGQAEDTIIVTEDGYENLTR 296
Cdd:TIGR00501 241 LDKLGDEkylFALNNLIRHGLIYDYPVLNEISGGYVAQWEHTILVEEHGKEVTTK 295
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 6-296 1.72e-47

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 165.27  E-value: 1.72e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894   6 LDDETVEKYREAGEVLRTVLDESAEMVEPGVTHLEVAEHAEARIREL--ADGC----AFPVNISVNEEASHASPGRDDDT 79
Cdd:PTZ00053  153 LSEEQYQDLRRAAEVHRQVRRYAQSVIKPGVKLIDICERIESKSRELieADGLkcgwAFPTGCSLNHCAAHYTPNTGDKT 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  80 VFGEDMVC-LDVGVHVDGYIADSAVTVDLSGN-DELVESAEEALDAALDmvEAG--AHTGKIGAEIEDVIRGY-----GY 150
Cdd:PTZ00053  233 VLTYDDVCkLDFGTHVNGRIIDCAFTVAFNPKyDPLLQATKDATNTGIK--EAGidVRLSDIGAAIQEVIESYeveikGK 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894 151 T----PVLNLSGHGVEQWDAHTDPTIPN-RGADRGVELEvGDVVAIEPFATDGTGKVSEGSKNEIYsLVNDRS----VRD 221
Cdd:PTZ00053  311 TypikSIRNLNGHSIGPYIIHGGKSVPIvKGGENTRMEE-GELFAIETFASTGRGYVNEDLECSHY-MKDPGAefvpLRL 388

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1221648894 222 RMSRKLLDEVREKYKLLPFAARWFEGG---RSEMAIRRLEQQGILRGYPVLKEEDGALVGQAEDTIIVTEDGYENLTR 296
Cdd:PTZ00053  389 PKAKQLLKHINTNFGTLAFCRRWLDRLgqdRHLLALKQLVDAGIVNPYPPLCDVRGSYTSQMEHTILLRPTCKEVLSR 466
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
7-202 1.61e-44

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 151.70  E-value: 1.61e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894   7 DDETVEKYREAGEVLRTVLDESAEMVEPGVTHLEVAEHAEARIRELadGC--------AFP--VNISVNEEASHASPGrd 76
Cdd:COG0024     5 TPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDH--GAipaflgyyGFPksICTSVNEVVVHGIPS-- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  77 dDTVFGE-DMVCLDVGVHVDGYIADSAVTV---DLSGNDE-LVESAEEALDAALDMVEAGAHTGKIGAEIEDVIRGYGYT 151
Cdd:COG0024    81 -DRVLKDgDIVNIDVGAILDGYHGDSARTFvvgEVSPEARrLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGYS 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1221648894 152 PVLNLSGHGVEQwDAHTDPTIPNRG-ADRGVELEVGDVVAIEPFATDGTGKV 202
Cdd:COG0024   160 VVREFVGHGIGR-EMHEEPQVPNYGrPGRGPRLKPGMVLAIEPMINAGTPEV 210
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 12-193 1.24e-32

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 119.27  E-value: 1.24e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  12 EKYREAGEVLRTVLDESAEMVEPGVTHLEVAE--HAEARIRELADGCAFP--VNISVNEEASHASPgrDDDTVFGEDMVC 87
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAelEAARLRRGGARGPAFPpiVASGPNAAIPHYIP--NDRVLKPGDLVL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  88 LDVGVHVD-GYIADSAVTVDLSGND----ELVESAEEALDAALDMVEAGAHTGKIGAEIEDVIRGYGY-TPVLNLSGHGV 161
Cdd:pfam00557  79 IDVGAEYDgGYCSDITRTFVVGKPSpeqrELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLgEYFPHGLGHGI 158

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1221648894 162 EQwDAHTDPTIPNRGADRgvELEVGDVVAIEP 193
Cdd:pfam00557 159 GL-EVHEGPYISRGGDDR--VLEPGMVFTIEP 187
 
Name Accession Description Interval E-value
MetAP2 cd01088
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 12-296 1.43e-130

Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238521 [Multi-domain]  Cd Length: 291  Bit Score: 372.35  E-value: 1.43e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  12 EKYREAGEVLRTVLDESAEMVEPGVTHLEVAEHAEARIRELADGCAFPVNISVNEEASHASPGRDDDTVFGE-DMVCLDV 90
Cdd:cd01088     2 EKYREAGEIHRQVRKYAQSLIKPGMTLLEIAEFVENRIRELGAGPAFPVNLSINECAAHYTPNAGDDTVLKEgDVVKLDF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  91 GVHVDGYIADSAVTVDLSGN-DELVESAEEALDAALDMVEAGAHTGKIGAEIEDVIRGYGYTPVLNLSGHGVEQWDAHTD 169
Cdd:cd01088    82 GAHVDGYIADSAFTVDFDPKyDDLLEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIESYGFKPIRNLTGHSIERYRLHAG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894 170 PTIPNRGADRGVELEVGDVVAIEPFATDGTGKVSEGSKNEIYSLVNDRSVRDRMSRKLLDEVREKYKLLPFAARWFEG-- 247
Cdd:cd01088   162 KSIPNVKGGEGTRLEEGDVYAIEPFATTGKGYVHDGPECSIYMLNRDKPLRLPRARKLLDVIYENFGTLPFARRWLDRlg 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1221648894 248 -GRSEMAIRRLEQQGILRGYPVLKEEDGALVGQAEDTIIVTEDGYENLTR 296
Cdd:cd01088   242 eTKLLMALKNLCKAGIVYPYPVLKEISGGYVAQFEHTIIVREDGKEVTTR 291
met_pdase_II TIGR00501
methionine aminopeptidase, type II; Methionine aminopeptidase (map) is a cobalt-binding enzyme. ...
 7-296 9.01e-104

methionine aminopeptidase, type II; Methionine aminopeptidase (map) is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. The role of this protein in general is to produce the mature amino end of cytosolic proteins by removing the N-terminal methionine. This model describes type II, among which the eukaryotic members typically have an N-terminal extension not present in archaeal members. It can act cotranslationally. The enzyme from rat has been shown to associate with translation initiation factor 2 (IF-2) and may have a role in translational regulation. [Protein fate, Protein modification and repair]


Pssm-ID: 129592  Cd Length: 295  Bit Score: 304.79  E-value: 9.01e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894   7 DDETVEKYREAGEVLRTVLDESAEMVEPGVTHLEVAEHAEARIRELADGCAFPVNISVNEEASHASPGRDDDTVFG-EDM 85
Cdd:TIGR00501   1 DIERAEKWIEAGKIHSKVRREAADRIVPGVKLLEVAEFVENRIRELGAEPAFPCNISINECAAHFTPKAGDKTVFKdGDV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  86 VCLDVGVHVDGYIADSAVTVDLSGN-DELVESAEEALDAALDMVEAGAHTGKIGAEIEDVIRGYGYTPVLNLSGHGVEQW 164
Cdd:TIGR00501  81 VKLDLGAHVDGYIADTAITVDLGDQyDNLVKAAKDALYTAIKEIRAGVRVGEIGKAIQEVIESYGVKPISNLTGHSMAPY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894 165 DAHTDPTIPNRGADRGVELEVGDVVAIEPFATDGTGKVSEGSKNEIYSLVNDRSVRDRMSRKLLDEVREKYKLLPFAARW 244
Cdd:TIGR00501 161 RLHGGKSIPNVKERDTTKLEEGDVVAIEPFATDGVGYVTDGGEVSIYAFLAERPVRLDSARNLLKTIDENYGTLPFARRW 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1221648894 245 FEGGRSE---MAIRRLEQQGILRGYPVLKEEDGALVGQAEDTIIVTEDGYENLTR 296
Cdd:TIGR00501 241 LDKLGDEkylFALNNLIRHGLIYDYPVLNEISGGYVAQWEHTILVEEHGKEVTTK 295
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 6-296 1.72e-47

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 165.27  E-value: 1.72e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894   6 LDDETVEKYREAGEVLRTVLDESAEMVEPGVTHLEVAEHAEARIREL--ADGC----AFPVNISVNEEASHASPGRDDDT 79
Cdd:PTZ00053  153 LSEEQYQDLRRAAEVHRQVRRYAQSVIKPGVKLIDICERIESKSRELieADGLkcgwAFPTGCSLNHCAAHYTPNTGDKT 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  80 VFGEDMVC-LDVGVHVDGYIADSAVTVDLSGN-DELVESAEEALDAALDmvEAG--AHTGKIGAEIEDVIRGY-----GY 150
Cdd:PTZ00053  233 VLTYDDVCkLDFGTHVNGRIIDCAFTVAFNPKyDPLLQATKDATNTGIK--EAGidVRLSDIGAAIQEVIESYeveikGK 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894 151 T----PVLNLSGHGVEQWDAHTDPTIPN-RGADRGVELEvGDVVAIEPFATDGTGKVSEGSKNEIYsLVNDRS----VRD 221
Cdd:PTZ00053  311 TypikSIRNLNGHSIGPYIIHGGKSVPIvKGGENTRMEE-GELFAIETFASTGRGYVNEDLECSHY-MKDPGAefvpLRL 388

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1221648894 222 RMSRKLLDEVREKYKLLPFAARWFEGG---RSEMAIRRLEQQGILRGYPVLKEEDGALVGQAEDTIIVTEDGYENLTR 296
Cdd:PTZ00053  389 PKAKQLLKHINTNFGTLAFCRRWLDRLgqdRHLLALKQLVDAGIVNPYPPLCDVRGSYTSQMEHTILLRPTCKEVLSR 466
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
7-202 1.61e-44

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 151.70  E-value: 1.61e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894   7 DDETVEKYREAGEVLRTVLDESAEMVEPGVTHLEVAEHAEARIRELadGC--------AFP--VNISVNEEASHASPGrd 76
Cdd:COG0024     5 TPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDH--GAipaflgyyGFPksICTSVNEVVVHGIPS-- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  77 dDTVFGE-DMVCLDVGVHVDGYIADSAVTV---DLSGNDE-LVESAEEALDAALDMVEAGAHTGKIGAEIEDVIRGYGYT 151
Cdd:COG0024    81 -DRVLKDgDIVNIDVGAILDGYHGDSARTFvvgEVSPEARrLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGYS 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1221648894 152 PVLNLSGHGVEQwDAHTDPTIPNRG-ADRGVELEVGDVVAIEPFATDGTGKV 202
Cdd:COG0024   160 VVREFVGHGIGR-EMHEEPQVPNYGrPGRGPRLKPGMVLAIEPMINAGTPEV 210
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 11-202 1.32e-43

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 148.80  E-value: 1.32e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  11 VEKYREAGEVLRTVLDESAEMVEPGVTHLEVAEHAEARIRELADGCA------FP--VNISVNEEASHASPgrdDDTVFG 82
Cdd:cd01086     1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGAYPAplgyygFPksICTSVNEVVCHGIP---DDRVLK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  83 E-DMVCLDVGVHVDGYIADSAVTVDLSGNDE----LVESAEEALDAALDMVEAGAHTGKIGAEIEDVIRGYGYTPVLNLS 157
Cdd:cd01086    78 DgDIVNIDVGVELDGYHGDSARTFIVGEVSEeakkLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFG 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1221648894 158 GHGVEQwDAHTDPTIPNRG-ADRGVELEVGDVVAIEPFATDGTGKV 202
Cdd:cd01086   158 GHGIGR-KFHEEPQIPNYGrPGTGPKLKPGMVFTIEPMINLGTYEV 202
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 7-295 1.05e-39

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 142.72  E-value: 1.05e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894   7 DDETVEKYREAGEVLRTVLDESAEMVEPGVTHLEVAEHAEARIRE-----------LADGCAFPVNISVNEEASHASPGR 75
Cdd:TIGR00495  16 NPEVVTKYKMAGEIANNVLKSVVEACSPGAKVVDICEKGDAFIMEetakifkkekeMEKGIAFPTCISVNNCVGHFSPLK 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  76 -DDDTVFGE-DMVCLDVGVHVDGYIADSAVTVDLSGNDE---------LVESAEEALDAALDMVEAGAHTGKIGAEIEDV 144
Cdd:TIGR00495  96 sDQDYILKEgDVVKIDLGCHIDGFIALVAHTFVVGVAQEepvtgrkadVIAAAHLAAEAALRLVKPGNTNTQVTEAINKV 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894 145 IRGYGYTPVLNLSGHGVEQWDAHTDPTIPNRGADRG------VELEVGDVVAIEPFATDGTGKVSE-GSKNEIYSLVNDR 217
Cdd:TIGR00495 176 AHSYGCTPVEGMLSHQLKQHVIDGEKVIISNPSDSQkkdhdtAEFEENEVYAVDILVSTGEGKAKDaDQRTTIYKRDPSK 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894 218 SVRDRM--SRKLLDEVREKYKLLPFAARWFEG-GRSEMAIRRLEQQGILRGYPVLKEEDGALVGQAEDTIIVTEDGYENL 294
Cdd:TIGR00495 256 TYGLKMkaSRAFFSEIERRFDAMPFTLRNFEDeKRARMGLVECVKHELLQPYPVLYEKEGEFVAQFKFTVLLMPNGPMRI 335


                  .
gi 1221648894 295 T 295
Cdd:TIGR00495 336 T 336
PRK05716 PRK05716
methionine aminopeptidase; Validated
 1-295 2.59e-38

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 135.65  E-value: 2.59e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894   1 MSIGPLDDETVEKYREAGEVLRTVLDESAEMVEPGVTHLEVAEHAEARIRELADGCA------FP--VNISVNEEASHAS 72
Cdd:PRK05716    1 MAITIKTPEEIEKMRVAGRLAAEVLDEIEPHVKPGVTTKELDRIAEEYIRDQGAIPAplgyhgFPksICTSVNEVVCHGI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  73 PgrdDDTVFGE-DMVCLDVGVHVDGYIADSAVTV---DLSGNDE-LVESAEEALDAALDMVEAGAHTGKIGAEIEDVIRG 147
Cdd:PRK05716   81 P---SDKVLKEgDIVNIDVTVIKDGYHGDTSRTFgvgEISPEDKrLCEVTKEALYLGIAAVKPGARLGDIGHAIQKYAEA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894 148 YGYTPVLNLSGHGVEQwDAHTDPTIPNRG-ADRGVELEVGDVVAIEPFATDGTGKVSEGSKNeiyslvndrsvrdrmsrk 226
Cdd:PRK05716  158 EGFSVVREYCGHGIGR-KFHEEPQIPHYGaPGDGPVLKEGMVFTIEPMINAGKREVKTLKDG------------------ 218

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1221648894 227 lldevrekykllpfaarWfeggrsemairrleqqgilrgypVLKEEDGALVGQAEDTIIVTEDGYENLT 295
Cdd:PRK05716  219 -----------------W-----------------------TVVTKDGSLSAQYEHTVAVTEDGPEILT 247
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 8-295 8.18e-36

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 129.19  E-value: 8.18e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894   8 DETVEKYREAGEVLRTVLDESAEMVEPGVTHLEVAEHAEARIRELA-----DGC-AFP--VNISVNEEASHASPgrdDDT 79
Cdd:PRK12896   13 PRELEKMRKIGRIVATALKEMGKAVEPGMTTKELDRIAEKRLEEHGaipspEGYyGFPgsTCISVNEEVAHGIP---GPR 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  80 VFGE-DMVCLDVGVHVDGYIADSAVTVdLSGN-----DELVESAEEALDAALDMVEAGAHTGKIGAEIEDVIRGYGYTPV 153
Cdd:PRK12896   90 VIKDgDLVNIDVSAYLDGYHGDTGITF-AVGPvseeaEKLCRVAEEALWAGIKQVKAGRPLNDIGRAIEDFAKKNGYSVV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894 154 LNLSGHGVEQwDAHTDPTIPNRGADR--GVELEVGDVVAIEPFatdgtgkVSEGSKNEiyslvndRSVRDrmsrklldev 231
Cdd:PRK12896  169 RDLTGHGVGR-SLHEEPSVILTYTDPlpNRLLRPGMTLAVEPF-------LNLGAKDA-------ETLDD---------- 223

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1221648894 232 rekykllpfaaRWfeggrsemairrleqqgilrgypVLKEEDGALVGQAEDTIIVTEDGYENLT 295
Cdd:PRK12896  224 -----------GW-----------------------TVVTPDKSLSAQFEHTVVVTRDGPEILT 253
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 12-193 1.24e-32

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 119.27  E-value: 1.24e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  12 EKYREAGEVLRTVLDESAEMVEPGVTHLEVAE--HAEARIRELADGCAFP--VNISVNEEASHASPgrDDDTVFGEDMVC 87
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAelEAARLRRGGARGPAFPpiVASGPNAAIPHYIP--NDRVLKPGDLVL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  88 LDVGVHVD-GYIADSAVTVDLSGND----ELVESAEEALDAALDMVEAGAHTGKIGAEIEDVIRGYGY-TPVLNLSGHGV 161
Cdd:pfam00557  79 IDVGAEYDgGYCSDITRTFVVGKPSpeqrELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLgEYFPHGLGHGI 158

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1221648894 162 EQwDAHTDPTIPNRGADRgvELEVGDVVAIEP 193
Cdd:pfam00557 159 GL-EVHEGPYISRGGDDR--VLEPGMVFTIEP 187
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 11-194 2.89e-24

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 97.14  E-value: 2.89e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  11 VEKYREAGEVLRTVLDESAEMVEPGVTHLEVAEHAEARIRELADGCAFPVNISVNEEAShASPGRDDDTVFGE-DMVCLD 89
Cdd:cd01066     1 IARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGGYPAGPTIVGSGARTA-LPHYRPDDRRLQEgDLVLVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  90 VGVHVDGYIADSAVTVDLSGND----ELVESAEEALDAALDMVEAGAHTGKIGAEIEDVIRGYGYTP-VLNLSGHGVEQW 164
Cdd:cd01066    80 LGGVYDGYHADLTRTFVIGEPSdeqrELYEAVREAQEAALAALRPGVTAEEVDAAAREVLEEHGLGPnFGHRTGHGIGLE 159

                         170       180       190
                  ....*....|....*....|....*....|
gi 1221648894 165 DaHTDPTIPnrgADRGVELEVGDVVAIEPF 194
Cdd:cd01066   160 I-HEPPVLK---AGDDTVLEPGMVFAVEPG 185
PA2G4-like cd01089
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family ...
 11-163 1.01e-21

Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.


Pssm-ID: 238522  Cd Length: 228  Bit Score: 90.85  E-value: 1.01e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  11 VEKYREAGEVLRTVLDESAEMVEPGVTHLEVAEHAEARIRE-----------LADGCAFPVNISVNEEASHASPGRDDDT 79
Cdd:cd01089     1 VTKYKTAGQIANKVLKQVISLCVPGAKVVDLCEKGDKLILEelgkvykkekkLEKGIAFPTCISVNNCVCHFSPLKSDAT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  80 VFGE--DMVCLDVGVHVDGYIADSAVTV---------DLSGNDELVESAEEALDAALDMVEAGAHTGKIGAEIEDVIRGY 148
Cdd:cd01089    81 YTLKdgDVVKIDLGCHIDGYIAVVAHTIvvgaeaetpVTGKKADVIAAAHYALEAALRLLRPGNQNSDITEAIQKVIVDY 160

                         170
                  ....*....|....*
gi 1221648894 149 GYTPVLNLSGHGVEQ 163
Cdd:cd01089   161 GCTPVEGVLSHQLKR 175
PRK12897 PRK12897
type I methionyl aminopeptidase;
11-198 9.34e-19

type I methionyl aminopeptidase;


Pssm-ID: 171806  Cd Length: 248  Bit Score: 83.54  E-value: 9.34e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  11 VEKYREAGEVLRTVLDESAEMVEPGVTHLEVAEHAEARIRELA--------DGCAFPVNISVNEEASHASPGrddDTVFG 82
Cdd:PRK12897   10 IDLMHESGKLLASCHREIAKIMKPGITTKEINTFVEAYLEKHGatseqkgyNGYPYAICASVNDEMCHAFPA---DVPLT 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  83 E-DMVCLDVGVHVDGYIADSAVTV---DLSGNDE-LVESAEEALDAALDMVEAGAHTGKIGAEIEDVIRGYGYTPVLNLS 157
Cdd:PRK12897   87 EgDIVTIDMVVNLNGGLSDSAWTYrvgKVSDEAEkLLLVAENALYKGIDQAVIGNRVGDIGYAIESYVANEGFSVARDFT 166

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1221648894 158 GHGVEQwDAHTDPTIPNRGAD-RGVELEVGDVVAIEPFATDG 198
Cdd:PRK12897  167 GHGIGK-EIHEEPAIFHFGKQgQGPELQEGMVITIEPIVNVG 207
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
7-193 1.40e-18

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 83.72  E-value: 1.40e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894   7 DDETVEKYREAGEVLRTVLDESAEMVEPGVTHLEVAEHAEARIREL-ADGCAFPVNISVNEEASHASPGRDDDTVFGEDM 85
Cdd:COG0006    75 SPEEIELMRKAARIADAAHEAALAALRPGVTEREVAAELEAAMRRRgAEGPSFDTIVASGENAAIPHYTPTDRPLKPGDL 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  86 VCLDVGVHVDGYIADSAVTVDLSGND----ELVESAEEALDAALDMVEAGAHTGKIGAEIEDVIRGYGYTPVLNLS-GHG 160
Cdd:COG0006   155 VLIDAGAEYDGYTSDITRTVAVGEPSdeqrEIYEAVLEAQEAAIAALKPGVTGGEVDAAARDVLAEAGYGEYFPHGtGHG 234

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1221648894 161 V--EQWDAhtdptiPNRGADRGVELEVGDVVAIEP 193
Cdd:COG0006   235 VglDVHEG------PQISPGNDRPLEPGMVFTIEP 263
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 11-193 9.58e-17

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 76.78  E-value: 9.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  11 VEKYREAGEVLRTVLDESAEMVEPGVTHLEVAEHAEARIREL-ADGCAFPVNISVNEEAS--HASPGrddDTVFGE-DMV 86
Cdd:cd01092     1 IELLRKAARIADKAFEELLEFIKPGMTEREVAAELEYFMRKLgAEGPSFDTIVASGPNSAlpHGVPS---DRKIEEgDLV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  87 CLDVGVHVDGYIADSAVTVDL-SGNDELVESAE---EALDAALDMVEAGAHTGKIGAEIEDVIRGYGYTPVLNLS-GHGV 161
Cdd:cd01092    78 LIDFGAIYDGYCSDITRTVAVgEPSDELKEIYEivlEAQQAAIKAVKPGVTAKEVDKAARDVIEEAGYGEYFIHRtGHGV 157

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1221648894 162 eQWDAHTDPTIPNRGADrgvELEVGDVVAIEP 193
Cdd:cd01092   158 -GLEVHEAPYISPGSDD---VLEEGMVFTIEP 185
PLN03158 PLN03158
methionine aminopeptidase; Provisional
 9-296 1.69e-13

methionine aminopeptidase; Provisional


Pssm-ID: 215607 [Multi-domain]  Cd Length: 396  Bit Score: 70.25  E-value: 1.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894   9 ETVEKYREAGEVLRTVLDESAEMVEPGVTHLEVAE--HaEARIRelADGCAFPVN---------ISVNEEASHASPgrDD 77
Cdd:PLN03158  141 EQIQRMRETCRIAREVLDAAARAIKPGVTTDEIDRvvH-EATIA--AGGYPSPLNyhffpksccTSVNEVICHGIP--DA 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  78 DTVFGEDMVCLDVGVHVDGYIADSAVTVDLSGNDE----LVESAEEALDAALDMVEAGAHTGKIGAEIEDVIRGYGYTPV 153
Cdd:PLN03158  216 RKLEDGDIVNVDVTVYYKGCHGDLNETFFVGNVDEasrqLVKCTYECLEKAIAIVKPGVRYREVGEVINRHATMSGLSVV 295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894 154 LNLSGHGVEQWdAHTDPTIPNRGADRGVE-LEVGDVVAIEPfatdgtgkvsegskneiysLVNDRSVRDRMsrklldevr 232
Cdd:PLN03158  296 KSYCGHGIGEL-FHCAPNIPHYARNKAVGvMKAGQVFTIEP-------------------MINAGVWRDRM--------- 346

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1221648894 233 ekykllpfaarWFEGGRSEMAirrleqqgilrgypvlkeeDGALVGQAEDTIIVTEDGYENLTR 296
Cdd:PLN03158  347 -----------WPDGWTAVTA-------------------DGKRSAQFEHTLLVTETGVEVLTA 380
PRK07281 PRK07281
methionyl aminopeptidase;
11-199 3.32e-09

methionyl aminopeptidase;


Pssm-ID: 180918  Cd Length: 286  Bit Score: 56.78  E-value: 3.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  11 VEKYREAGEVLRTVLDESAEMVEPGVTHLEVAEHAEARIREladGCAFPVNISV---------------NEEASHASPGR 75
Cdd:PRK07281   10 IEAMDRAGDFLASIHIGLRDLIKPGVDMWEVEEYVRRRCKE---ENVLPLQIGVdgammdypyatccglNDEVAHAFPRH 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1221648894  76 ---------DDDTVFGE--DMVCLDVGV-----------HVDGY---IADS----AVTVDLSGNDELVESAEEALDAALD 126
Cdd:PRK07281   87 yilkegdllKVDMVLSEplDKSIVDVSKlnfdnveqmkkYTESYrggLADScwayAVGTPSDEVKNLMDVTKEAMYRGIE 166

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1221648894 127 MVEAGAHTGKIGAEIEDVIRGYGYTPVLNLSGHGVEQwDAHTDPTIPNRG-ADRGVELEVGDVVAIEPFATDGT 199
Cdd:PRK07281  167 QAVVGNRIGDIGAAIQEYAESRGYGVVRDLVGHGVGP-TMHEEPMVPNYGtAGRGLRLREGMVLTIEPMINTGT 239
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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