|
Name |
Accession |
Description |
Interval |
E-value |
| GT4_CapM-like |
cd03808 |
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ... |
17-377 |
4.75e-31 |
|
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.
Pssm-ID: 340837 [Multi-domain] Cd Length: 358 Bit Score: 121.16 E-value: 4.75e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 17 TFVVTEINALVKTGHKVSVITFENLNNSANLDS-SVKVIIIKKSFGAAAKFAVFKPLAVLKTakialrftsisatsllgy 95
Cdd:cd03808 14 SFRLPLIKALVKKGYEVHVIAPDGDKLSDELKElGVKVIDIPILRRGINPLKDLKALFKLYK------------------ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 96 glniaeIIKQHGISHLHCHFMHAPLaYSIIASKIAGI--SVSSI-GHGHdVYVNDTDLKL------KLSLCDFSVAVC-- 164
Cdd:cd03808 76 ------LLKKEKPDIVHCHTPKPGI-LGRLAARLAGVpkVIYTVhGLGF-VFTEGKLLRLlyllleKLALLFTDKVIFvn 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 165 ---KDMAQKLSNYNVGKVELL-HCGVDLSLFSATPNRLN-ESVKLLFIGRLVEKKGLQFLLPAIKKLSKKYA-ICLDIVG 238
Cdd:cd03808 148 eddRDLAIKKGIIKKKKTVLIpGSGVDLDRFQYSPESLPsEKVVFLFVARLLKDKGIDELIEAAKILKKKGPnVRFLLVG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 239 EGPLMNDLKFLCEELGLDKDIRFLGRRtplwlsKNTSNYSALVAPFCVSSNgdRDTGPVVLKEAMASGIPVLTTKLMGAK 318
Cdd:cd03808 228 DGELENPSEILIEKLGLEGRIEFLGFR------SDVPELLAESDVFVLPSY--REGLPRSLLEAMAAGRPVITTDVPGCR 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 319 EIVNDSV-GFKCEPSSIIGLETILTQFCElNPYERYAKGVNAKRLVANKFNASSQAKKLS 377
Cdd:cd03808 300 ELVIDGVnGFLVPPGDVEALADAIEKLIE-DPELRKEMGEAARKRVEEKFDEEKVVNKLL 358
|
|
| GT4_WlbH-like |
cd03798 |
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ... |
15-376 |
3.05e-30 |
|
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.
Pssm-ID: 340828 [Multi-domain] Cd Length: 376 Bit Score: 119.41 E-value: 3.05e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 15 SETFVVTEINALVKTGHKVSVITFEnlnnsanldssvkviiikkSFGAAAKFAVFKPLAVLKTAKIALRFTSISATSLLG 94
Cdd:cd03798 16 RGIFVRRQVRALSRRGVDVEVLAPA-------------------PWGPAAARLLRKLLGEAVPPRDGRRLLPLKPRLRLL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 95 YGLNIAEIIKQHGISH------LHCHFMHAPLAYSIIASKIAGISVSSIGHGHDVYVNDT------DLKLKLSLCDFSVA 162
Cdd:cd03798 77 APLRAPSLAKLLKRRRrgppdlIHAHFAYPAGFAAALLARLYGVPYVVTEHGSDINVFPPrsllrkLLRWALRRAARVIA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 163 VCKDMAQKLSNYNV--GKVELLHCGVDLSLFSATPNRLN---ESVKLLFIGRLVEKKGLQFLLPAIKKLSKKY-AICLDI 236
Cdd:cd03798 157 VSKALAEELVALGVprDRVDVIPNGVDPARFQPEDRGLGlplDAFVILFVGRLIPRKGIDLLLEAFARLAKARpDVVLLI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 237 VGEGPLMNDLKFLCEELGLDKDIRFLGRRT----PLWLskNTSnySALVAPfcvSSngdRDTGPVVLKEAMASGIPVLTT 312
Cdd:cd03798 237 VGDGPLREALRALAEDLGLGDRVTFTGRLPheqvPAYY--RAC--DVFVLP---SR---HEGFGLVLLEAMACGLPVVAT 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1222444046 313 KLMGAKEIVNDS-VGFKCEPSSIIGLETILTQfcELNPYERYAKGVNAKRLVANKFNASSQAKKL 376
Cdd:cd03798 307 DVGGIPEVVGDPeTGLLVPPGDADALAAALRR--ALAEPYLRELGEAARARVAERFSWVKAADRI 369
|
|
| GT4_AmsK-like |
cd03799 |
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ... |
4-368 |
2.06e-29 |
|
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.
Pssm-ID: 340829 [Multi-domain] Cd Length: 350 Bit Score: 116.40 E-value: 2.06e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 4 IGIVVPSFHIPSETFVVTEINALVKTGHKVSVITFENLNnSANLDSSVKviiikkSFGAAAKFAVFKPLAVLKTAKialr 83
Cdd:cd03799 2 IAFIVDEFPVLSETFILNQITGLIDRGHEVDIYAVNPGD-LVKRHPDVE------KYNVPSLNLLYAIVGLNKKGA---- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 84 ftsisatsllgyglniAEIIkqhgishlHCHFMH----APLAYSIIAskIAGISVSSIgHGHDV--YVNDTDLKLKLSLC 157
Cdd:cd03799 71 ----------------YDII--------HCQFGPlgalGALLRRLKV--LKGKLVTSF-RGYDIsmYVILEGNKVYPQLF 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 158 ---DFSVAVCKDMAQKLSNYNVG--KVELLHCGVDLSLFSATPNRL--NESVKLLFIGRLVEKKGLQFLLPAIKKLSKKY 230
Cdd:cd03799 124 aqgDLFLPNCELFKHRLIALGCDekKIIVHRSGIDCNKFRFKPRYLplDGKIRILTVGRLTEKKGLEYAIEAVAKLAQKY 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 231 A-ICLDIVGEGPLMNDLKFLCEELGLDKDIRFLGRRTPLWLSKNTSNYSALVAPFCVSSNGDRDTGPVVLKEAMASGIPV 309
Cdd:cd03799 204 PnIEYQIIGDGDLKEQLQQLIQELNIGDCVKLLGWKPQEEIIEILDEADIFIAPSVTAADGDQDGPPNTLKEAMAMGLPV 283
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 310 LTTKLMGAKEIVNDSV-GFKCEPSSIIGLETILTQFCElNPYERYAKGVNAKRLVANKFN 368
Cdd:cd03799 284 ISTEHGGIPELVEDGVsGFLVPERDAEAIAEKLTYLIE-HPAIWPEMGKAGRARVEEEYD 342
|
|
| GT4_PimA-like |
cd03801 |
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ... |
3-376 |
9.51e-29 |
|
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.
Pssm-ID: 340831 [Multi-domain] Cd Length: 366 Bit Score: 114.94 E-value: 9.51e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 3 HIGIVVPSFHIPS---ETFVVTEINALVKTGHKVSVITFENLNNSANldssvKVIIIKKSFGAAAKFAVFKPLAVLKTAK 79
Cdd:cd03801 1 KILLLSPELPPPVggaERHVRELARALAARGHDVTVLTPADPGEPPE-----ELEDGVIVPLLPSLAALLRARRLLRELR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 80 IALRFTSISAtsllgyglniaeiikqhgishLHCHFMHAPLAYSIIASKIAGISVSSIgHGHDVYVNDTDLKLKLSL--- 156
Cdd:cd03801 76 PLLRLRKFDV---------------------VHAHGLLAALLAALLALLLGAPLVVTL-HGAEPGRLLLLLAAERRLlar 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 157 -------CDFSVAVCKDMAQKLSNYNV---GKVELLHCGVDLSLFS----ATPNRLNESVKLLFIGRLVEKKGLQFLLPA 222
Cdd:cd03801 134 aeallrrADAVIAVSEALRDELRALGGippEKIVVIPNGVDLERFSpplrRKLGIPPDRPVLLFVGRLSPRKGVDLLLEA 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 223 IKKLSKKYAIC-LDIVG-EGPLMNDLKFLceELGLDKDIRFLGRRTPLWLSKNTSNYSALVAPfcvssnGDRDTGPVVLK 300
Cdd:cd03801 214 LAKLLRRGPDVrLVIVGgDGPLRAELEEL--ELGLGDRVRFLGFVPDEELPALYAAADVFVLP------SRYEGFGLVVL 285
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1222444046 301 EAMASGIPVLTTKLMGAKEIVNDSV-GFKCEPSSIIGLETILTQFCElNPYERYAKGVNAKRLVANKFNASSQAKKL 376
Cdd:cd03801 286 EAMAAGLPVVATDVGGLPEVVEDGEgGLVVPPDDVEALADALLRLLA-DPELRARLGRAARERVAERFSWERVAERL 361
|
|
| GT4_GT28_WabH-like |
cd03811 |
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ... |
11-356 |
2.41e-28 |
|
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.
Pssm-ID: 340839 [Multi-domain] Cd Length: 351 Bit Score: 113.61 E-value: 2.41e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 11 FHIPS------ETFVVTEINALVKTGHKVSVITFENLNN-SANLDSSVKVIIIKksfgaaakfavfkplavlktakiaLR 83
Cdd:cd03811 4 FVIPSlsgggaERVLLNLANALDKRGYDVTLVLLRDEGDlDKQLNGDVKLIRLL------------------------IR 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 84 FTSISATSLLGYGLNIAEIIKQHGISHLHCHFMHAPlaysIIASKIAGISVSSIGHGHDVYVNDTDLKLKLSL------- 156
Cdd:cd03811 60 VLKLIKLGLLKAILKLKRILKRAKPDVVISFLGFAT----YIVAKLAAARSKVIAWIHSSLSKLYYLKKKLLLklklykk 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 157 CDFSVAVCKDMA---QKLSNYNVGKVELLHCGVDLSLFSATPNRLNESVK-----LLFIGRLVEKKGLQFLLPAIKKLSK 228
Cdd:cd03811 136 ADKIVCVSKGIKedlIRLGPSPPEKIEVIYNPIDIDRIRALAKEPILNEPedgpvILAVGRLDPQKGHDLLIEAFAKLRK 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 229 KYAIC-LDIVGEGPLMNDLKFLCEELGLDKDIRFLGRRTPLWlskntsNYSALVAPFCVSSngDRDTGPVVLKEAMASGI 307
Cdd:cd03811 216 KYPDVkLVILGDGPLREELEKLAKELGLAERVIFLGFQSNPY------PYLKKADLFVLSS--RYEGFPNVLLEAMALGT 287
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1222444046 308 PVLTTKLMGAKEIVNDSV-GFKCEPSSIIGLETILTQFCELNP----YERYAKG 356
Cdd:cd03811 288 PVVSTDCPGPREILDDGEnGLLVPDGDAAALAGILAALLQKKLdaalRERLAKA 341
|
|
| GT4_UGDG-like |
cd03817 |
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ... |
3-334 |
3.98e-26 |
|
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.
Pssm-ID: 340844 [Multi-domain] Cd Length: 372 Bit Score: 107.75 E-value: 3.98e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 3 HIGIVVPSFhIPSETFVVTEINALVKT----GHKVSVITfENLNNSANLDSSVKVIIIKKSFGAAAKFAVFKPLAVLKTA 78
Cdd:cd03817 1 KIAIFTDTY-LPQVNGVATSVRNLARAlekrGHEVYVIT-PSDPGAEDEEEVVRYRSFSIPIRKYHRQHIPFPFKKAVID 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 79 KIA-LRFTSISATSLLGYGLNIAEIIKQHGISHLHC-HFM------HAPLAYSIIASKIAGISVSSIGHGHDVyvndtdl 150
Cdd:cd03817 79 RIKeLGPDIIHTHTPFSLGKLGLRIARKLKIPIVHTyHTMyedylhYIPKGKLLVKAVVRKLVRRFYNHTDAV------- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 151 klklslcdfsVAVCKDMAQKLSNYNV-GKVELLHCGVDLSLFSATPNR--------LNESVKLLFIGRLVEKKGLQFLLP 221
Cdd:cd03817 152 ----------IAPSEKIKDTLREYGVkGPIEVIPNGIDLDKFEKPLNTeerrklglPPDEPILLYVGRLAKEKNIDFLLR 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 222 AIKKLSKKYAICLDIVGEGPLMNDLKFLCEELGLDKDIRFLG----RRTPLWlskntsnYSALVApFCVSSngDRDTGPV 297
Cdd:cd03817 222 AFAELKKEPNIKLVIVGDGPEREELKELARELGLADKVIFTGfvprEELPEY-------YKAADL-FVFAS--TTETQGL 291
|
330 340 350
....*....|....*....|....*....|....*...
gi 1222444046 298 VLKEAMASGIPVLTTKLMGAKEIVNDSV-GFKCEPSSI 334
Cdd:cd03817 292 VYLEAMAAGLPVVAAKDPAASELVEDGEnGFLFEPNDE 329
|
|
| GT4_WavL-like |
cd03819 |
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ... |
16-322 |
1.12e-22 |
|
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.
Pssm-ID: 340846 [Multi-domain] Cd Length: 345 Bit Score: 97.43 E-value: 1.12e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 16 ETFVVTEINALVKTGHKVSVITfenlnnsanldssvkviiikksfgaaakfAVFKPLAVLKTAKIALRFTSISATSLLGY 95
Cdd:cd03819 14 ETYILDLARALAERGHRVLVVT-----------------------------AGGPLLPRLRQIGIGLPGLKVPLLRALLG 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 96 GLNIAEIIKQHGISHLHCHfMHAPLAYSIIASKIAGISVSSIGHGHD-VYVNDTDLKLKLSL-CDFSVAVCKDMAQKL-S 172
Cdd:cd03819 65 NVRLARLIRRERIDLIHAH-SRAPAWLGWLASRLTGVPLVTTVHGSYlATYHPKDFALAVRArGDRVIAVSELVRDHLiE 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 173 NYNV--GKVELLHCGVDLSLFSATPNRL--------NESVKLLFIGRLVEKKGLQFLLPAIKKLSKKYAICLDIVGEGPL 242
Cdd:cd03819 144 ALGVdpERIRVIPNGVDTDRFPPEAEAEeraqlglpEGKPVVGYVGRLSPEKGWLLLVDAAAELKDEPDFRLLVAGDGPE 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 243 MNDLKFLCEELGLDKDIRFLGRRTPLwlskntsnYSALVAPFCVSSNGDRDTGPVVLKEAMASGIPVLTTKLMGAKEIVN 322
Cdd:cd03819 224 RDEIRRLVERLGLRDRVTFTGFREDV--------PAALAASDVVVLPSLHEEFGRVALEAMACGTPVVATDVGGAREIVV 295
|
|
| GT4_AmsD-like |
cd03820 |
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ... |
4-368 |
8.97e-22 |
|
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.
Pssm-ID: 340847 [Multi-domain] Cd Length: 351 Bit Score: 95.00 E-value: 8.97e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 4 IGIVVPSFHIPS--ETFVVTEINALVKTGHKVSVITFENLNNSAN--LDSSVKVIIIKKSFGAAAKFaVFKPLAVLKTAK 79
Cdd:cd03820 2 IAIVIPSISNAGgaERVAINLANHLAKKGYDVTIISLDSAEKPPFyeLDDNIKIKNLGDRKYSHFKL-LLKYFKKVRRLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 80 IALRFTSISAT-SLLGYGLNIAEIIKQHGISHLHCHFmhAPLAYSIIASKIAGIsvssighghdvyvndtdlKLKLSLCD 158
Cdd:cd03820 81 KYLKNNKPDVViSFRTSLLTFLALIGLKSKLIVWEHN--NYEAYNKGLRRLLLR------------------RLLYKRAD 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 159 FSVAVCKDMAQKLSNYNVGKVELLHCGVDLSLFSATPNRlnESVKLLFIGRLVEKKGLQFLLPAIKKLSKKYA-ICLDIV 237
Cdd:cd03820 141 KIVVLTEADKLKKYKQPNSNVVVIPNPLSFPSEEPSTNL--KSKRILAVGRLTYQKGFDLLIEAWALIAKKHPdWKLRIY 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 238 GEGPLMNDLKFLCEELGLDKDIRFLGRrtplwlSKNTSNY---SALvapFCVSSngdRDTG-PVVLKEAMASGIPVLTTK 313
Cdd:cd03820 219 GDGPEREELEKLIDKLGLEDRVKLLGP------TKNIAEEyanSSI---FVLSS---RYEGfPMVLLEAMAYGLPIISFD 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 314 LM-GAKEIVNDSV-GFKCEPSSIIGL-ETIltqfCEL--NPYERYAKGVNAkRLVANKFN 368
Cdd:cd03820 287 CPtGPSEIIEDGEnGLLVPNGDVDALaEAL----LRLmeDEELRKKMGKNA-RKNAERFS 341
|
|
| GT4-like |
cd05844 |
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ... |
177-376 |
1.49e-20 |
|
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
Pssm-ID: 340860 [Multi-domain] Cd Length: 365 Bit Score: 91.75 E-value: 1.49e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 177 GKVELLHCGVDLSLFSATPNRLNESVkLLFIGRLVEKKGLQFLLPAIKKLSKKYA-ICLDIVGEGPLMNDLKFLCEELGl 255
Cdd:cd05844 166 ERIHVHYIGIDPAKFAPRDPAERAPT-ILFVGRLVEKKGCDVLIEAFRRLAARHPtARLVIAGDGPLRPALQALAAALG- 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 256 dkDIRFLGRRTPLWLSKNTSNYSALVAPFCVSSNGDRDTGPVVLKEAMASGIPVLTTKLMGAKEIVNDS-VGFKCEPSSI 334
Cdd:cd05844 244 --RVRFLGALPHAEVQDWMRRAEIFCLPSVTAASGDSEGLGIVLLEAAACGVPVVSSRHGGIPEAILDGeTGFLVPEGDV 321
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1222444046 335 IGL----ETILTqfcelNPYERYAKGVNAKRLVANKFNASSQAKKL 376
Cdd:cd05844 322 DALadalQALLA-----DRALADRMGGAARAFVCEQFDIRVQTAKL 362
|
|
| Glyco_trans_1_4 |
pfam13692 |
Glycosyl transferases group 1; |
203-337 |
2.02e-18 |
|
Glycosyl transferases group 1;
Pssm-ID: 463957 [Multi-domain] Cd Length: 138 Bit Score: 81.02 E-value: 2.02e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 203 KLLFIGRLVEK-KGLQFLLPAIKKLSKK-YAICLDIVGEGPlMNDLKFLCEelGLDKDIRFLGRRTPL--WLSKntsnYS 278
Cdd:pfam13692 3 VILFVGRLHPNvKGVDYLLEAVPLLRKRdNDVRLVIVGDGP-EEELEELAA--GLEDRVIFTGFVEDLaeLLAA----AD 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1222444046 279 ALVAPFcvssngDRDTGPVVLKEAMASGIPVLTTKLMGAKEIVNDSVGFKCEPSSIIGL 337
Cdd:pfam13692 76 VFVLPS------LYEGFGLKLLEAMAAGLPVVATDVGGIPELVDGENGLLVPPGDPEAL 128
|
|
| Glycos_transf_1 |
pfam00534 |
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ... |
203-361 |
3.59e-17 |
|
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.
Pssm-ID: 425737 [Multi-domain] Cd Length: 158 Bit Score: 78.08 E-value: 3.59e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 203 KLLFIGRLVEKKGLQFLLPAIKKLSKKY-AICLDIVGEGPLMNDLKFLCEELGLDKDIRFLGRRTPLWLSKNTSNYSALV 281
Cdd:pfam00534 4 IILFVGRLEPEKGLDLLIKAFALLKEKNpNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVFV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 282 APfcvssnGDRDTGPVVLKEAMASGIPVLTTKLMGAKEIVNDSV-GFKCEPSSIIGLETILTQFCELNP-YERYAKgvNA 359
Cdd:pfam00534 84 LP------SRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGEtGFLVKPNNAEALAEAIDKLLEDEElRERLGE--NA 155
|
..
gi 1222444046 360 KR 361
Cdd:pfam00534 156 RK 157
|
|
| GT4_WbuB-like |
cd03794 |
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ... |
22-376 |
2.11e-16 |
|
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.
Pssm-ID: 340825 [Multi-domain] Cd Length: 391 Bit Score: 80.08 E-value: 2.11e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 22 EINALVKTGHKVSVITFENLNNSANLDSSVK-----VIIIKKSFGAAAKFAVFKPLAvlktakIALRFTSISATSLLGYG 96
Cdd:cd03794 23 LAKELVRRGHEVTVLTPSPNYPLGRIFAGATetkdgIRVIRVKLGPIKKNGLIRRLL------NYLSFALAALLKLLVRE 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 97 LNIAEIIkqhgiSHLHCHFMHAPlaySIIASKIAGISVssIGHGHDVYVND--------TDLKLK---------LSLCDF 159
Cdd:cd03794 97 ERPDVII-----AYSPPITLGLA---ALLLKKLRGAPF--ILDVRDLWPESlialgvlkKGSLLKllkklerklYRLADA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 160 SVAVCKDMAQKLSNYNV--GKVELLHCGVDLSLFSATPNR-------LNESVKLLFIGRLVEKKGLQFLLPAIKKLSKKY 230
Cdd:cd03794 167 IIVLSPGLKEYLLRKGVpkEKIIVIPNWADLEEFKPPPKDelrkklgLDDKFVVVYAGNIGKAQGLETLLEAAERLKRRP 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 231 AICLDIVGEGPLMNDLKFLCEELGLDkDIRFLGR----RTPLWLSK---NTSNYSALVAPFCVSsngdrdtgPVVLKEAM 303
Cdd:cd03794 247 DIRFLFVGDGDEKERLKELAKARGLD-NVTFLGRvpkeEVPELLSAadvGLVPLKDNPANRGSS--------PSKLFEYM 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1222444046 304 ASGIPVLTTKLMGAKEIVNDS-VGFKCEPSSIIGLETILTQFCElNPYERYAKGVNAKRLVANKFNASSQAKKL 376
Cdd:cd03794 318 AAGKPILASDDGGSDLAVEINgCGLVVEPGDPEALADAILELLD-DPELRRAMGENGRELAEEKFSREKLADRL 390
|
|
| GT4_WbnK-like |
cd03807 |
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ... |
16-378 |
5.49e-16 |
|
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.
Pssm-ID: 340836 [Multi-domain] Cd Length: 362 Bit Score: 78.51 E-value: 5.49e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 16 ETFVVTEINALVKTGHKVSVITFENLNNSAN--LDSSVKVIIIKKSFGaaakfavFKPLAVLKTAKIalrftsisatsll 93
Cdd:cd03807 15 ETMLLRLLEHMDKSRFEHVVISLTGDGVLGEelLAAGVPVVCLGLSSG-------KDPGVLLRLAKL------------- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 94 gyglniaeiIKQHGISHLHCHFMHAPLaYSIIASKIAGIS--VSSIGHGHDvYVNDTD--LKLKLSLCDFSVAVC----- 164
Cdd:cd03807 75 ---------IRKRNPDVVHTWMYHADL-IGGLAAKLAGGVkvIWSVRSSNI-PQRLTRlvRKLCLLLSKFSPATVanssa 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 165 -KDMAQKLsNYNVGKVELLHCGVDLSLFSATPNR---------LNESVKLLFI-GRLVEKKGLQFLLPAIKKLSKKY-AI 232
Cdd:cd03807 144 vAEFHQEQ-GYAKNKIVVIYNGIDLFKLSPDDASrararrrlgLAEDRRVIGIvGRLHPVKDHSDLLRAAALLVETHpDL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 233 CLDIVGEGPLMNDLKFLCEELGLDKDIRFLGRRtplwlskntSNYSALVAP---FCVSSngdRDTG-PVVLKEAMASGIP 308
Cdd:cd03807 223 RLLLVGRGPERPNLERLLLELGLEDRVHLLGER---------SDVPALLPAmdiFVLSS---RTEGfPNALLEAMACGLP 290
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 309 VLTTKLMGAKEIVNDSVGFKCEPSSIIGLETILTQFCELnPYERYAKGVNAKRLVANKFNASSQAKKLSS 378
Cdd:cd03807 291 VVATDVGGAAELVDDGTGFLVPAGDPQALADAIRALLED-PEKRARLGRAARERIANEFSIDAMVRRYET 359
|
|
| GT4_CapH-like |
cd03812 |
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ... |
91-377 |
8.84e-16 |
|
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).
Pssm-ID: 340840 [Multi-domain] Cd Length: 357 Bit Score: 77.71 E-value: 8.84e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 91 SLLGYGLNIAEIIKQHGISHLHCHFMHAPLAYSIIAsKIAGISVSsIGHGHDVYVNDTDLKLKLS---------LCDFSV 161
Cdd:cd03812 64 NIIKYFIKLLKLIKKEKYDIVHVHGSSSNGIILLLA-AKAGVPVR-IAHSHNTKDSSIKLRKIRKnvlkklierLSTKYL 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 162 AVCKDMAQKLSNYNV-GKVELLHCGVDLSLFSATPNRLNESVKLLF---------IGRLVEKKGLQFLLPAIKKLSKKYA 231
Cdd:cd03812 142 ACSEDAGEWLFGEVEnGKFKVIPNGIDIEKYKFNKEKRRKRRKLLIledklvlghVGRFNEQKNHSFLIDIFEELKKKNP 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 232 -ICLDIVGEGPLMNDLKFLCEELGLDKDIRFLGRRTPL--WLSKNT-----SNYSALvapfcvssngdrdtgPVVLKEAM 303
Cdd:cd03812 222 nVKLVLVGEGELKEKIKEKVKELGLEDKVIFLGFRNDVseILSAMDvflfpSLYEGL---------------PLVAVEAQ 286
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1222444046 304 ASGIPVLTTKLMGAKEIVNDSV-GFKCEPSSIIGLETILtqfcELNPYERYAKGVNAKRLVANKFNASSQAKKLS 377
Cdd:cd03812 287 ASGLPCLLSDTITKECDITNNVeFLPLNETPSTWAEKIL----KLIKRKRRINKEINKEKKELGYDDESLELTLL 357
|
|
| GT4-like |
cd03814 |
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ... |
157-332 |
3.07e-15 |
|
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.
Pssm-ID: 340842 [Multi-domain] Cd Length: 365 Bit Score: 76.18 E-value: 3.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 157 CDFSVAVCKDMAQKLSNYNVGKVELLHCGVDLSLF-----SATPNRL---NESVKLLFIGRLVEKKGLQFLLPAIKKLSK 228
Cdd:cd03814 146 FDTTLVPSPSIARELEGHGFERVRLWPRGVDTELFhpsrrDAALRRRlgpPGRPLLLYVGRLAPEKNLEALLDADLPLAA 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 229 KYAICLDIVGEGPLMNDLkflcEELGLdkDIRFLGRRTPLWLSKNTSNYSALVAPfcvssnGDRDT-GPVVLkEAMASGI 307
Cdd:cd03814 226 SPPVRLVVVGDGPARAEL----EARGP--DVIFTGFLTGEELARAYASADVFVFP------SRTETfGLVVL-EAMASGL 292
|
170 180
....*....|....*....|....*.
gi 1222444046 308 PVLTTKLMGAKEIVNDS-VGFKCEPS 332
Cdd:cd03814 293 PVVAADAGGPRDIVRPGgTGALVEPG 318
|
|
| Glycosyltransferase_GTB-type |
cd01635 |
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ... |
99-326 |
2.82e-14 |
|
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
Pssm-ID: 340816 [Multi-domain] Cd Length: 235 Bit Score: 71.67 E-value: 2.82e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 99 IAEIIKQHGISHLHCHFMHAPLAYSIIASKIAGISVSSIGHGHDVYVNdtdlklklslcdfsvavckdMAQKLSNYNVGK 178
Cdd:cd01635 46 ILKKLLELKPDVVHAHSPHAAALAALLAARLLGIPIVVTVHGPDSLES--------------------TRSELLALARLL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 179 VELLHCGVdlslfsatpnrlnesvklLFIGRLVEKKGLQFLLPAIKKLSKKYA-ICLDIVGEGPLMNDLKFLCEELGLDK 257
Cdd:cd01635 106 VSLPLADK------------------VSVGRLVPEKGIDLLLEALALLKARLPdLVLVLVGGGGEREEEEALAAALGLLE 167
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1222444046 258 DIRFLGrrtPLWLSKNTSNYSALVAPFCVSSngDRDTGPVVLKEAMASGIPVLTTKLMGAKEIVNDSVG 326
Cdd:cd01635 168 RVVIIG---GLVDDEVLELLLAAADVFVLPS--RSEGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGEN 231
|
|
| GT4_WfcD-like |
cd03795 |
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ... |
205-369 |
3.06e-14 |
|
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.
Pssm-ID: 340826 [Multi-domain] Cd Length: 355 Bit Score: 73.08 E-value: 3.06e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 205 LFIGRLVEKKGLQFLLPAIKKLskKYAICldIVGEGPLMNDLKFLCEELGLDKdIRFLGRRTplwlSKNTSNYSALVAPF 284
Cdd:cd03795 195 LFIGRLVYYKGLDYLIEAAQYL--NYPIV--IGGEGPLKPDLEAQIELNLLDN-VKFLGRVD----DEEKVIYLHLCDVF 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 285 CVSSNGDRDTGPVVLKEAMASGIPVLTTKL-MGAKEIVNDSV-GFKCEPSSIIGL-ETILTQFCELNPYERYAKgvNAKR 361
Cdd:cd03795 266 VFPSVLRSEAFGIVLLEAMMCGKPVISTNIgTGVPYVNNNGEtGLVVPPKDPDALaEAIDKLLSDEELRESYGE--NAKK 343
|
....*...
gi 1222444046 362 LVANKFNA 369
Cdd:cd03795 344 RFEELFTA 351
|
|
| GT4_BshA-like |
cd04962 |
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ... |
99-369 |
2.23e-13 |
|
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.
Pssm-ID: 340859 [Multi-domain] Cd Length: 370 Bit Score: 70.84 E-value: 2.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 99 IAEIIKQHGISHLHCHFM--HAPLAYsiIASKIAG--ISVSSIGHGHDVYVNDTDLKLKlSLCDFSV-------AVCKDM 167
Cdd:cd04962 76 IVEVAKEHKLDVLHAHYAipHASCAY--LAREILGekIPIVTTLHGTDITLVGYDPSLQ-PAVRFSInksdrvtAVSSSL 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 168 AQKL-SNYNVGK-VELLHCGVDLSLFSATPNR--------LNESVKLLFIGRLVEKKGLQFLLPAIKKLSKKYAICLDIV 237
Cdd:cd04962 153 RQETyELFDVDKdIEVIHNFIDEDVFKRKPAGalkrrllaPPDEKVVIHVSNFRPVKRIDDVVRVFARVRRKIPAKLLLV 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 238 GEGPLMNDLKFLCEELGLDKDIRFLGRRTPlwLSKNTSNYSALVAPFCVSSNGdrdtgpVVLKEAMASGIPVLTTKLMGA 317
Cdd:cd04962 233 GDGPERVPAEELARELGVEDRVLFLGKQDD--VEELLSIADLFLLPSEKESFG------LAALEAMACGVPVVSSNAGGI 304
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1222444046 318 KEIVNDSV-GFKCEPSSIIGLETILTQFceLNPYERYAK-GVNAKRLVANKFNA 369
Cdd:cd04962 305 PEVVKHGEtGFLSDVGDVDAMAKSALSI--LEDDELYNRmGRAARKRAAERFDP 356
|
|
| GT4_WbdM_like |
cd04951 |
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ... |
178-324 |
3.40e-13 |
|
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.
Pssm-ID: 340857 [Multi-domain] Cd Length: 360 Bit Score: 70.17 E-value: 3.40e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 178 KVELLHCGVDLSLFSATPNR---------LNESVKLLF-IGRLVEKKGLQFLLPAIKKLSKKYAIC-LDIVGEGPLMNDL 246
Cdd:cd04951 155 KSVPVYNGIDLNKFKKDINVrlkirnklnLKNDEFVILnVGRLTEAKDYPNLLLAISELILSKNDFkLLIAGDGPLRNEL 234
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1222444046 247 KFLCEELGLDKDIRFLGRRTplwlskNTSNYSALVAPFCVSSngdRDTG-PVVLKEAMASGIPVLTTKLMGAKEIVNDS 324
Cdd:cd04951 235 ERLICNLNLVDRVILLGQIS------NISEYYNAADLFVLSS---EWEGfGLVVAEAMACERPVVATDAGGVAEVVGDH 304
|
|
| GT4_WcaC-like |
cd03825 |
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ... |
161-382 |
5.31e-12 |
|
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.
Pssm-ID: 340851 [Multi-domain] Cd Length: 364 Bit Score: 66.59 E-value: 5.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 161 VAVCK---DMAQKLSNYNVGKVELLHCGVDLSLFSATPNRLN--------ESVKLLFIGRLVEK--KGLQFLLPAIKKLS 227
Cdd:cd03825 142 VAPSRwlaDMVRRSPLLKGLPVVVIPNGIDTEIFAPVDKAKArkrlgipqDKKVILFGAESVTKprKGFDELIEALKLLA 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 228 KKYAICLDIVGEGPLMNdlkflceeLGLDKDIRFLGrrtplWLSKNTS---NYSAlVAPFCVSSNgdRDTGPVVLKEAMA 304
Cdd:cd03825 222 TKDDLLLVVFGKNDPQI--------VILPFDIISLG-----YIDDDEQlvdIYSA-ADLFVHPSL--ADNLPNTLLEAMA 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 305 SGIPVLTTKLMGAKEIVNDSV-GFKCEPSSIIGL-ETILTqfCELNPYERYAKGVNAKRLVANKFNASSQAKKLSSWVQN 382
Cdd:cd03825 286 CGTPVVAFDTGGSPEIVQHGVtGYLVPPGDVQALaEAIEW--LLANPKERESLGERARALAENHFDQRVQAQRYLELYKD 363
|
|
| GT4_sucrose_synthase |
cd03800 |
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ... |
157-323 |
2.07e-11 |
|
sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.
Pssm-ID: 340830 [Multi-domain] Cd Length: 398 Bit Score: 64.95 E-value: 2.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 157 CDFSVAVCKDMAQKL-SNYNV--GKVELLHCGVDLSLFSATPNRLNESVKL---------LFIGRLVEKKGLQFLLPAIK 224
Cdd:cd03800 164 ADRVIASTPQEADELiSLYGAdpSRINVVPPGVDLERFFPVDRAEARRARLllppdkpvvLALGRLDPRKGIDTLVRAFA 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 225 KLSKKYAIC-LDIVGEGPLMND------LKFLCEELGLDKDIRFLGRRTP-----LWLSKNTSNYSALVAPFcvssngdr 292
Cdd:cd03800 244 QLPELRELAnLVLVGGPSDDPLsmdreeLAELAEELGLIDRVRFPGRVSRddlpeLYRAADVFVVPSLYEPF-------- 315
|
170 180 190
....*....|....*....|....*....|.
gi 1222444046 293 dtGPVVLkEAMASGIPVLTTKLMGAKEIVND 323
Cdd:cd03800 316 --GLTAI-EAMACGTPVVATAVGGLQDIVRD 343
|
|
| GT4_Bme6-like |
cd03821 |
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ... |
204-379 |
4.66e-11 |
|
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.
Pssm-ID: 340848 [Multi-domain] Cd Length: 377 Bit Score: 63.54 E-value: 4.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 204 LLFIGRLVEKKGLQFLLPAIKKLSKKYA-ICLDIVGEGPLMNDLKF-LCEELGLDKDIRFLGRRTPLWLSkntsnySALV 281
Cdd:cd03821 207 ILFLGRIHPKKGLDLLIRAARKLAEQGRdWHLVIAGPDDGAYPAFLqLQSSLGLGDRVTFTGPLYGEAKW------ALYA 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 282 AP--FCVSSNgdRDTGPVVLKEAMASGIPVLTTKLMGAKEIVNDSVGFKCEPsSIIGLETILTQFCElNPYERYAKGVNA 359
Cdd:cd03821 281 SAdlFVLPSY--SENFGNVVAEALACGLPVVITDKCGLSELVEAGCGVVVDP-NVSSLAEALAEALR-DPADRKRLGEMA 356
|
170 180
....*....|....*....|
gi 1222444046 360 KRLVankfnassQAKKLSSW 379
Cdd:cd03821 357 RRAR--------QVEENFSW 368
|
|
| RfaB |
COG0438 |
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ... |
284-376 |
9.31e-11 |
|
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440207 [Multi-domain] Cd Length: 123 Bit Score: 58.85 E-value: 9.31e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 284 FCVSSngDRDTGPVVLKEAMASGIPVLTTKLMGAKEIVNDSV-GFKCEPSSIIGLETILTQFCElNPYERYAKGVNAKRL 362
Cdd:COG0438 24 FVLPS--RSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGEtGLLVPPGDPEALAEAILRLLE-DPELRRRLGEAARER 100
|
90
....*....|....
gi 1222444046 363 VANKFNASSQAKKL 376
Cdd:COG0438 101 AEERFSWEAIAERL 114
|
|
| GT4_ExpE7-like |
cd03823 |
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ... |
6-361 |
4.67e-10 |
|
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).
Pssm-ID: 340850 [Multi-domain] Cd Length: 357 Bit Score: 60.42 E-value: 4.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 6 IVVPSFHIPS-----ETFVVTEINALVKTGHKVSVITFENLNNSanldsSVKVIIIKKSFGAAAKFAVFKPL-------- 72
Cdd:cd03823 3 LLVNSLYPPQrvggaEISVHDLAEALVAEGHEVAVLTAGVGPPG-----QATVARSVVRYRRAPDETLPLALkrrgyelf 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 73 --------AVLKTAKIALRFTSISATSLLGYGLNIAEIIKQHGIshlhchfmhaPLAYSIiaskiagisvssighgHDVY 144
Cdd:cd03823 78 etynpglrRLLARLLEDFRPDVVHTHNLSGLGASLLDAARDLGI----------PVVHTL----------------HDYW 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 145 vndtdlklklSLCDFS----------VAVCKDMAQKLSN--YNVGKVELLHCGVDLSLFSA-TPNRLNESVKLLFIGRLV 211
Cdd:cd03823 132 ----------LLCPRQflfkkggdavLAPSRFTANLHEAngLFSARISVIPNAVEPDLAPPpRRRPGTERLRFGYIGRLT 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 212 EKKGLQFLLPAIKKLsKKYAICLDIVGEGPLmNDlkflCEELGLDKDIRFLGR---RTPLWLskntsnYSA---LVAPfc 285
Cdd:cd03823 202 EEKGIDLLVEAFKRL-PREDIELVIAGHGPL-SD----ERQIEGGRRIAFLGRvptDDIKDF------YEKidvLVVP-- 267
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1222444046 286 vssNGDRDTGPVVLKEAMASGIPVLTTKLMGAKEIVNDSV-GFKCEPSSIIGLETILTQFCEL-NPYERYAKGVNAKR 361
Cdd:cd03823 268 ---SIWPEPFGLVVREAIAAGLPVIASDLGGIAELIQPGVnGLLFAPGDAEDLAAAMRRLLTDpALLERLRAGAEPPR 342
|
|
| GT4_MtfB-like |
cd03809 |
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ... |
170-376 |
1.26e-08 |
|
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.
Pssm-ID: 340838 [Multi-domain] Cd Length: 362 Bit Score: 56.22 E-value: 1.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 170 KLSNYNVGKVELLHCGVDLSLFSATPNRLNESVK------LLFIGRLVEKKGLQFLLPAIKKLSKKYAIC-LDIVGEGPL 242
Cdd:cd03809 155 KFYGVPPEKIVVIPLGVDPSFFPPESAAVLIAKYllpepyFLYVGTLEPRKNHERLLKAFALLKKQGGDLkLVIVGGKGW 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 243 MN-DLKFLCEELGLDKDIRFLGRrtplwLSKNT-----SNYSALVAP-----FCVssngdrdtgPVVlkEAMASGIPVLT 311
Cdd:cd03809 235 EDeELLDLVKKLGLGGRVRFLGY-----VSDEDlpalyRGARAFVFPslyegFGL---------PVL--EAMACGTPVIA 298
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1222444046 312 TKLMGAKEIVNDSvGFKCEPSSIIGLETILTQFCElNPYERYAKGVNAKRLvANKFNASSQAKKL 376
Cdd:cd03809 299 SNISVLPEVAGDA-ALYFDPLDPESIADAILRLLE-DPSLREELIRKGLER-AKKFSWEKTAEKT 360
|
|
| GT4_AviGT4-like |
cd03802 |
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ... |
4-331 |
3.74e-08 |
|
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.
Pssm-ID: 340832 [Multi-domain] Cd Length: 333 Bit Score: 54.60 E-value: 3.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 4 IGIVVPSFH-IPS------ETFVVTEINALVKTGHKVSVITFENLNNSANLDSSVKVIIIKKSFGAAAKfaVFKPLAVLK 76
Cdd:cd03802 2 IAQVSPPRGpVPPgkyggtELVVSALTEGLVRRGHEVTLFAPGDSHTSAPLVAVIPRALRLDPIPQESK--LAELLEALE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 77 TAKIAlrftsisatsllgyglNIAEIIkqhgisHLHCHFMHAPLAYSIIASkiagiSVSSIgHGHdvyvNDTDLKLKLSL 156
Cdd:cd03802 80 VQLRA----------------SDFDVI------HNHSYDWLPPFAPLIGTP-----FVTTL-HGP----SIPPSLAIYAA 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 157 CDFSVAVCKDMAQKLSNYNVGKVELLHCGVDLSLFsaTPNRLNESVkLLFIGRLVEKKGLQfllPAIKkLSKKYAICLDI 236
Cdd:cd03802 128 EPPVNYVSISDAQRAATPPIDYLTVVHNGLDPADY--RFQPDPEDY-LAFLGRIAPEKGLE---DAIR-VARRAGLPLKI 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 237 VGEGPLMNDLKFLCEELgLDKDIRFLGRRTPLWLSKNTSNYSALVAPfcvsSNGDRDTGPVVLkEAMASGIPVLTTKLMG 316
Cdd:cd03802 201 AGKVRDEDYFYYLQEPL-PGPRIEFIGEVGHDEKQELLGGARALLFP----INWDEPFGLVMI-EAMACGTPVIAYRRGG 274
|
330
....*....|....*.
gi 1222444046 317 AKEIVND-SVGFKCEP 331
Cdd:cd03802 275 LPEVIQHgETGFLVDS 290
|
|
| GT4_AmsK-like |
cd04946 |
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ... |
13-370 |
4.37e-08 |
|
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.
Pssm-ID: 340854 [Multi-domain] Cd Length: 401 Bit Score: 54.39 E-value: 4.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 13 IPSETFVVTEINALVKTGHKVsVITFENLNNSANLDSSVKVII---------IKKSFGAAAKF-AVFKPLAVLKTAKIA- 81
Cdd:cd04946 12 IKGETFIEEEIRYLSKSFLKI-YILPLHVKKVRRCVPSNNIEIsnslkitsfLKKIFRALSLFsLVFYKEIWIKDKPRSg 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 82 ---LRFTSISATSLLG---YGLNIAEIIKQHGISHLHCHFMHAPLAYSIIASKIAGISVSSIGHGHDVYVNDTDLK---L 152
Cdd:cd04946 91 sflLLYYFLIASFLSKhrvLALLQFVSIFGQGTVVYSYWLNHTALGLGLLKDEYYRDVVISRAHRYDLYEDQYGSYylpL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 153 KLSLCDFSVAVC------KDMAQK-LSNYNvGKVELLHCGVDLSLFSATPnRLNESVKLLFIGRLVEKKGLQFLLPAIKK 225
Cdd:cd04946 171 REYLVSYLDAVFliskegKDYLQKcYPAYK-EKIFVSRLGVSDKEQYSKV-KKEGDLRLVSCSSIVPVKRIDLIIETLNS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 226 LS-KKYAICLDI--VGEGPLMNDLKFLCEELGLDKDIRFLGRRTplwlSKNTSNYSaLVAPFCVSSNGDRDTG-PVVLKE 301
Cdd:cd04946 249 LCvAHPSICISWthIGGGPLKERLEKLAENKLENVKVNFTGEVS----NKEVKQLY-KENDVDVFVNVSESEGiPVSIME 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1222444046 302 AMASGIPVLTTKLMGAKEIVNDSVGF-----KCEPSSIIglETILTQFCELNPYERYAKgvNAKRLVANKFNAS 370
Cdd:cd04946 324 AISFGIPVIATNVGGTREIVENETNGllldkDPTPNEIV--SSIMKFYLDGGDYKTMKI--SARECWEERFNAE 393
|
|
| PRK09922 |
PRK09922 |
lipopolysaccharide 1,6-galactosyltransferase; |
152-346 |
8.36e-08 |
|
lipopolysaccharide 1,6-galactosyltransferase;
Pssm-ID: 182148 [Multi-domain] Cd Length: 359 Bit Score: 53.56 E-value: 8.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 152 LKLSLCDFSVAVCKDMAQKLSNYNVG--KVELLHCGVDLSLFSATPNRLNESVKLLFIGRLVEK--KGLQFLLPAIKKLS 227
Cdd:PRK09922 129 KKITCADYHLAISSGIKEQMMARGISaqRISVIYNPVEIKTIIIPPPERDKPAVFLYVGRLKFEgqKNVKELFDGLSQTT 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 228 KKYAicLDIVGEGPLMNDLKFLCEELGLDKDIRFLGRRTPLW--LSKNTSNYSALVapfcVSSNGDrdtG-PVVLKEAMA 304
Cdd:PRK09922 209 GEWQ--LHIIGDGSDFEKCKAYSRELGIEQRIIWHGWQSQPWevVQQKIKNVSALL----LTSKFE---GfPMTLLEAMS 279
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1222444046 305 SGIPVLTTKLM-GAKEIVNDSV-GFKCEPSSIIGLETILTQFCE 346
Cdd:PRK09922 280 YGIPCISSDCMsGPRDIIKPGLnGELYTPGNIDEFVGKLNKVIS 323
|
|
| GT4-like |
cd03813 |
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ... |
178-371 |
1.17e-07 |
|
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.
Pssm-ID: 340841 [Multi-domain] Cd Length: 474 Bit Score: 53.49 E-value: 1.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 178 KVELLHCGVDLSLFSATPNRLNESVKLL--FIGRLVEKKGLQFLLPAIKKLSKKYAIC-LDIVG---EGPL-MNDLKFLC 250
Cdd:cd03813 268 KTRVIPNGIDIQRFAPAREERPEKEPPVvgLVGRVVPIKDVKTFIRAFKLVRRAMPDAeGWLIGpedEDPEyAQECKRLV 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 251 EELGLDKDIRFLGRRtplwlskNTSNY---SALVAPFCVSsngdrDTGPVVLKEAMASGIPVLTTKLMGAKEIVND---- 323
Cdd:cd03813 348 ASLGLENKVKFLGFQ-------NIKEYypkLGLLVLTSIS-----EGQPLVILEAMASGVPVVATDVGSCRELIYGadda 415
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1222444046 324 --SVGFKCEPSSIIGLETILTQFCElNPYERYAKGVNAKRLVANKFNASS 371
Cdd:cd03813 416 lgQAGLVVPPADPEALAEALIKLLR-DPELRQAFGEAGRKRVEKYYTLEG 464
|
|
| GT4_GtfA-like |
cd04949 |
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ... |
185-311 |
1.85e-07 |
|
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.
Pssm-ID: 340855 [Multi-domain] Cd Length: 328 Bit Score: 52.30 E-value: 1.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 185 GVDLSLFSATPNRLNESVKLLFIGRLVEKKGLQFLLPAIKKLSKK-YAICLDIVGEGPLMNDLKFLCEELGLDKDIRFLG 263
Cdd:cd04949 144 GYVDQLDTAESNHERKSNKIITISRLAPEKQLDHLIEAVAKAVKKvPEITLDIYGYGEEREKLKKLIEELHLEDNVFLKG 223
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1222444046 264 RRTPL-------WLSKNTSNYsalvapfcvssngdrDTGPVVLKEAMASGIPVLT 311
Cdd:cd04949 224 YHSNLdqeyqdaYLSLLTSQM---------------EGFGLTLMEAIGHGLPVVS 263
|
|
| GT4_WbaZ-like |
cd03804 |
mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 ... |
158-323 |
4.00e-07 |
|
mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbaZ in Salmonella enterica has been shown to possess mannosyltransferase activity.
Pssm-ID: 340833 [Multi-domain] Cd Length: 356 Bit Score: 51.52 E-value: 4.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 158 DFSVAVCKDMAQKLSNYNVGKVELLHCGVDLSLFSATPNRLNESVKLlfiGRLVEKKGLQFLLPAIKKLSKKyaicLDIV 237
Cdd:cd03804 159 DLFIANSQFVARRIKKFYGRESTVIYPPVDTDAFAPAADKEDYYLTA---SRLVPYKRIDLAVEAFNELPKR----LVVI 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 238 GEGPLMNDLKFLceelgLDKDIRFLGRRTPLWLSKNTSNYSALVAPfcvssnGDRDTGPVVLkEAMASGIPVLTTKLMGA 317
Cdd:cd03804 232 GDGPDLDRLRAM-----ASPNVEFLGYQPDEVLKELLSKARAFVFA------AEEDFGIVPV-EAQACGTPVIAFGKGGA 299
|
....*.
gi 1222444046 318 KEIVND 323
Cdd:cd03804 300 LETVRP 305
|
|
| Glyco_transf_4 |
pfam13439 |
Glycosyltransferase Family 4; |
16-189 |
8.15e-07 |
|
Glycosyltransferase Family 4;
Pssm-ID: 463877 [Multi-domain] Cd Length: 169 Bit Score: 48.68 E-value: 8.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 16 ETFVVTEINALVKTGHKVSVITFENLNNSANLDSSVKVIiikksfgaaakfaVFKPLAVLKTAKIALRFTsisatsllgy 95
Cdd:pfam13439 4 ERYVLELARALARRGHEVTVVTPGGPGPLAEEVVRVVRV-------------PRVPLPLPPRLLRSLAFL---------- 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 96 gLNIAEIIKQHGISHLHCHFMHAPLAYSIIASKIAGI-SVSSIgHGHDVYVNDTDLKLK-------------LSLCDFSV 161
Cdd:pfam13439 61 -RRLRRLLRRERPDVVHAHSPFPLGLAALAARLRLGIpLVVTY-HGLFPDYKRLGARLSplrrllrrlerrlLRRADRVI 138
|
170 180 190
....*....|....*....|....*....|.
gi 1222444046 162 AVCKDMAQKL-SNYNV--GKVELLHCGVDLS 189
Cdd:pfam13439 139 AVSEAVADELrRLYGVppEKIRVIPNGVDLE 169
|
|
| PRK15179 |
PRK15179 |
Vi polysaccharide biosynthesis protein TviE; Provisional |
236-325 |
4.62e-06 |
|
Vi polysaccharide biosynthesis protein TviE; Provisional
Pssm-ID: 185101 [Multi-domain] Cd Length: 694 Bit Score: 48.49 E-value: 4.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 236 IVGEGPLMNDLKFLCEELGLDKDIRFLG--RRTPLWLSKntSNYSALVAPFcvssngdrDTGPVVLKEAMASGIPVLTTK 313
Cdd:PRK15179 553 MVGGGPLLESVREFAQRLGMGERILFTGlsRRVGYWLTQ--FNAFLLLSRF--------EGLPNVLIEAQFSGVPVVTTL 622
|
90
....*....|..
gi 1222444046 314 LMGAKEIVNDSV 325
Cdd:PRK15179 623 AGGAGEAVQEGV 634
|
|
| GT4_PIG-A-like |
cd03796 |
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This ... |
186-333 |
6.81e-06 |
|
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder.
Pssm-ID: 340827 [Multi-domain] Cd Length: 398 Bit Score: 47.62 E-value: 6.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 186 VDLSLFSATPN-RLNESVKLLFIGRLVEKKGLQFLLPAIKKLSKKYA-ICLDIVGEGPLMNDLKFLCEELGLDKDIRFLG 263
Cdd:cd03796 177 VDSSDFTPDPSkPDPNKITIVVISRLVYRKGIDLLVGIIPRICKKHPnVRFIIGGDGPKRIELEEMREKYQLQDRVELLG 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 264 -----------RRTPLWLskNTSnysaLVAPFCVSsngdrdtgpvvLKEAMASGIPVLTTKLMGAKEIVNDSVGFKCEPS 332
Cdd:cd03796 257 avpheevrdvlVQGHIFL--NTS----LTEAFCIA-----------IVEAASCGLLVVSTRVGGIPEVLPPDMILLAEPD 319
|
.
gi 1222444046 333 S 333
Cdd:cd03796 320 P 320
|
|
| PLN02871 |
PLN02871 |
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase |
204-360 |
2.15e-04 |
|
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
Pssm-ID: 215469 [Multi-domain] Cd Length: 465 Bit Score: 43.16 E-value: 2.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 204 LLFIGRLVEKKGLQFLLPAIKKLSkkyAICLDIVGEGPLMNDLkflcEELGLDKDIRFLGRRTPLWLSKNTSNYSALVAP 283
Cdd:PLN02871 266 IVYVGRLGAEKNLDFLKRVMERLP---GARLAFVGDGPYREEL----EKMFAGTPTVFTGMLQGDELSQAYASGDVFVMP 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 284 fcvssnGDRDT-GPVVLkEAMASGIPVLTTKLMGAKEIVNDS----VGFKCEPSSIIGLETILTQFCElNPYERYAKGVN 358
Cdd:PLN02871 339 ------SESETlGFVVL-EAMASGVPVVAARAGGIPDIIPPDqegkTGFLYTPGDVDDCVEKLETLLA-DPELRERMGAA 410
|
..
gi 1222444046 359 AK 360
Cdd:PLN02871 411 AR 412
|
|
| GT4_ALG2-like |
cd03805 |
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ... |
136-367 |
3.52e-04 |
|
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.
Pssm-ID: 340834 [Multi-domain] Cd Length: 392 Bit Score: 42.19 E-value: 3.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 136 SIGHGHDVYVNDtdlklklslcDFSVAVCKDMAQKLSNYnvgKVELLHCGVDLSLFSATPNRLNESVKLLF--------I 207
Cdd:cd03805 151 TTGMADQIVVNS----------NFTAGVFKKTFPSLAKN---PPEVLYPCVDTDSFDSTSEDPDPGDLIAKsnkkfflsI 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 208 GRLVEKKGLQFLLPAIKKLSKKYA----ICLDIVG---EGPLMN-----DLKFLCEEL-GLDKDIRFLgrRTP-----LW 269
Cdd:cd03805 218 NRFERKKNIALAIEAFAKLKQKLPefenVRLVIAGgydPRVAENveyleELQRLAEELlNVEDQVLFL--RSIsdsqkEQ 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 270 LSKNTSnySALVAP----FcvssngdrdtGPVVLkEAMASGIPVLTTKLMGAKE-IVNDSVGFKCEPSSIIGLETILTQF 344
Cdd:cd03805 296 LLSSAL--ALLYTPsnehF----------GIVPL-EAMYAGKPVIACNSGGPLEtVVEGVTGFLCEPTPEAFAEAMLKLA 362
|
250 260
....*....|....*....|...
gi 1222444046 345 CELNPYERYakGVNAKRLVANKF 367
Cdd:cd03805 363 NDPDLADRM--GAAGRKRVKEKF 383
|
|
| GT4_mannosyltransferase-like |
cd03822 |
mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most ... |
141-354 |
1.66e-03 |
|
mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides.
Pssm-ID: 340849 [Multi-domain] Cd Length: 370 Bit Score: 40.06 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 141 HDVYVNDTDLKLKLSLCDFSVavcKDMAQKLSNYNVGKVELLHCGVDL----SLFSATPNRLNESVK-LLFIGRLVEKKG 215
Cdd:cd03822 125 LKVLFRIATLSERVVVMAPIS---RFLLVRIKLIPAVNIEVIPHGVPEvpqdPTTALKRLLLPEGKKvILTFGFIGPGKG 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222444046 216 LQFLLPAIKKLSKKYA-ICLDIVGE-------GPLMNDLKFLCEELGLDKDIRFLGRrtplWLSKNT-----SNYSALVA 282
Cdd:cd03822 202 LEILLEALPELKAEFPdVRLVIAGElhpslarYEGERYRKAAIEELGLQDHVDFHNN----FLPEEEvpryiSAADVVVL 277
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1222444046 283 PF---CVSSNGdrdtgpvVLKEAMASGIPVLTTKLMGAKEIVNDSVGFKCEPSSIIGLETILTQFCElNPYERYA 354
Cdd:cd03822 278 PYlntEQSSSG-------TLSYAIACGKPVISTPLRHAEELLADGRGVLVPFDDPSAIAEAILRLLE-DDERRQA 344
|
|
| |
