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Conserved domains on  [gi|1253028337|ref|WP_096913407|]
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MULTISPECIES: IS3 family transposase [Enterobacterales]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09409 super family cl32366
IS2 transposase TnpB; Reviewed
 109-400 3.51e-178

IS2 transposase TnpB; Reviewed


The actual alignment was detected with superfamily member PRK09409:

Pssm-ID: 181829 [Multi-domain]  Cd Length: 301  Bit Score: 498.09  E-value: 3.51e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 109 VDSARALVAGGWRISLVSRCLRVSRAQLHAMARRSKGWQDRRCKRKPDDTEALARIHTVIDDLPTYGYRRVWALLRRQSE 188
Cdd:PRK09409    1 MDSARALIARGWGVSLVSRCLRVSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 189 TDDMAVINAKRVYRIMRQNALLLERKPAIPPSKRAHRGKVAVGESNQRWCSDGFEFSCDNGEKLRVTFALDCCDREALHW 268
Cdd:PRK09409   81 LDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHW 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 269 AASTGGYDSETVQDVMLGAVERRFGNRLPTSPVEWLTDNGSAYRSHQTRQFARMVGLEPKHTAVRSPESNGMAESFVKTM 348
Cdd:PRK09409  161 AVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1253028337 349 KRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRRRTSNG 400
Cdd:PRK09409  241 KRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNG 292
HTH_CRP super family cl46859
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 1-118 8.04e-64

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


The actual alignment was detected with superfamily member PRK09413:

Pssm-ID: 481199  Cd Length: 121  Bit Score: 200.41  E-value: 8.04e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337   1 MIDVLGPEKRRRRSVQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELASAMKQI 80
Cdd:PRK09413    1 MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQI 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1253028337  81 KELQRLLGKKTMENELLKEAVEYGRPKKVDSARALVAG 118
Cdd:PRK09413   81 KELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPG 118
 
Name Accession Description Interval E-value
PRK09409 PRK09409
IS2 transposase TnpB; Reviewed
 109-400 3.51e-178

IS2 transposase TnpB; Reviewed


Pssm-ID: 181829 [Multi-domain]  Cd Length: 301  Bit Score: 498.09  E-value: 3.51e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 109 VDSARALVAGGWRISLVSRCLRVSRAQLHAMARRSKGWQDRRCKRKPDDTEALARIHTVIDDLPTYGYRRVWALLRRQSE 188
Cdd:PRK09409    1 MDSARALIARGWGVSLVSRCLRVSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 189 TDDMAVINAKRVYRIMRQNALLLERKPAIPPSKRAHRGKVAVGESNQRWCSDGFEFSCDNGEKLRVTFALDCCDREALHW 268
Cdd:PRK09409   81 LDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHW 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 269 AASTGGYDSETVQDVMLGAVERRFGNRLPTSPVEWLTDNGSAYRSHQTRQFARMVGLEPKHTAVRSPESNGMAESFVKTM 348
Cdd:PRK09409  161 AVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1253028337 349 KRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRRRTSNG 400
Cdd:PRK09409  241 KRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNG 292
transpos_IS3 NF033516
IS3 family transposase;
16-392 2.11e-100

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 302.56  E-value: 2.11e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337  16 QEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAaGEQVVPaseLASAMKQIKELQRLLGKKTMENE 95
Cdd:NF033516    1 EFKLEAVREVLEGGKSVAEVARELGISPSTLYRWRKKYRGGGEAADA-GRLKEL---LTPEEEENRRLKRELAELRLENE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337  96 LLKEAVEYGRP-KKVDSARALvAGGWRISLVSRCLRVSRAQLHAMARRskgwqdRRCKRKPDDTEALARIHTVIDDLP-T 173
Cdd:NF033516   77 ILKKARKLLRPaVKYALIDAL-RGEYSVRRACRVLGVSRSTYYYWRKR------PPSRRAPDDAELRARIREIFEESRgR 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 174 YGYRRVWALLRRQSEtddmaVINAKRVYRIMRQNALLLERKPAIPP--SKRAHRGKVA---------VGESNQRWCSDGF 242
Cdd:NF033516  150 YGYRRITALLRREGI-----RVNHKRVYRLMRELGLLARRRRKRRPytTDSGHVHPVApnllnrqftATRPNQVWVTDIT 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 243 EFSCDNGeKLRVTFALDCCDREALHWAASTGgYDSETVQDVMLGAVERRfgnRLPtSPVEWLTDNGSAYRSHQTRQFARM 322
Cdd:NF033516  225 YIRTAEG-WLYLAVVLDLFSREIVGWSVSTS-MSAELVLDALEMAIEWR---GKP-EGLILHSDNGSQYTSKAYREWLKE 298

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 323 VGLEPKHTAVRSPESNGMAESFVKTMKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREY 392
Cdd:NF033516  299 HGITQSMSRPGNCWDNAVAESFFGTLKRECLYRRRFRTLEEARQAIEEYIEFYNHERPHSSLGYLTPAEF 368
PRK09413 PRK09413
IS2 repressor TnpA; Reviewed
 1-118 8.04e-64

IS2 repressor TnpA; Reviewed


Pssm-ID: 181833  Cd Length: 121  Bit Score: 200.41  E-value: 8.04e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337   1 MIDVLGPEKRRRRSVQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELASAMKQI 80
Cdd:PRK09413    1 MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQI 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1253028337  81 KELQRLLGKKTMENELLKEAVEYGRPKKVDSARALVAG 118
Cdd:PRK09413   81 KELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPG 118
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
82-399 1.85e-57

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 190.36  E-value: 1.85e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337  82 ELQRLLGKKTMENELLKEAVEYGRPKKVDSARALVAGGWRISLVSRCLRVSRAQLHAMARRSKGWqdrrckRKPDDTEAL 161
Cdd:COG2801     1 ELAEEEELRKEEELLRRLLLLLRLLLLRRRVLRRVSRRRRRLLRLLRRRRARSRRRRRLRRPRSY------RADEDAELL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 162 ARIHTVIDDLPTYGYRRVWALLRRQSETddmavINAKRVYRIMRQNALLLE-RKPAIPPSKRAHRGKVA------VGESN 234
Cdd:COG2801    75 ERIKEIFAESPRYGYRRITAELRREGIA-----VNRKRVRRLMRELGLQARrRRKKKYTTYSGHGGPIApnllftATAPN 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 235 QRWCSDGFEFSCDNGeKLRVTFALDCCDREALHWAASTGGyDSETVQDVMLGAVERRFgnrlPTSPVEWLTDNGSAYRSH 314
Cdd:COG2801   150 QVWVTDITYIPTAEG-WLYLAAVIDLFSREIVGWSVSDSM-DAELVVDALEMAIERRG----PPKPLILHSDNGSQYTSK 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 315 QTRQFARMVGLEPKHTAVRSPESNGMAESFVKTMKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLR 394
Cdd:COG2801   224 AYQELLKKLGITQSMSRPGNPQDNAFIESFFGTLKYELLYRRRFESLEEAREAIEEYIEFYNHERPHSSLGYLTPAEYEK 303


                  ....*
gi 1253028337 395 RRTSN 399
Cdd:COG2801   304 QLAAA 308
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
7-103 1.28e-20

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 85.75  E-value: 1.28e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337   7 PEKRRRRSVQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASElasamkQIKELQRL 86
Cdd:COG2963     2 SKKRRRYSPEFKAEAVRLVLEGGASVAEVARELGISPSTLYRWVRQYREGGLGGFPGDGRTTPEQA------EIRRLRKE 75

                          90
                  ....*....|....*..
gi 1253028337  87 LGKKTMENELLKEAVEY 103
Cdd:COG2963    76 LRRLEMENDILKKAAAL 92
transpos_IS481 NF033577
IS481 family transposase; null
 112-393 2.13e-20

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 90.34  E-value: 2.13e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 112 ARALVAGGWRISLVSRCLRVSRAQLHAMARRSK-----GWQDR--RCKRKPD--DTEALARIHTVIDDLpTYGYRRVWAL 182
Cdd:NF033577    6 VRLVLEDGWSVREAARRFGISRKTVYKWLKRYRaggeeGLIDRsrRPHRSPRrtSPETEARILALRREL-RLGPRRIAYE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 183 LRRQSETddmavINAKRVYRIMRQNAL--LLERKPAIPPSKRAHRGKvavgeSNQRWCSDGFEFS--CDNGeKLRVTFAL 258
Cdd:NF033577   85 LERQGPG-----VSRSTVHRILRRHGLsrLRALDRKTGKVKRYERAH-----PGELWHIDIKKLGriPDVG-RLYLHTAI 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 259 DCCDREALHWAastggYDSETVQDVMlGAVERRFgNRLPTSPVEWLTDNGSAYRSHQT--RQFARMVGLEPKHTAVRSPE 336
Cdd:NF033577  154 DDHSRFAYAEL-----YPDETAETAA-DFLRRAF-AEHGIPIRRVLTDNGSEFRSRAHgfELALAELGIEHRRTRPYHPQ 226

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1253028337 337 SNGMAESFVKTMKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYL 393
Cdd:NF033577  227 TNGKVERFHRTLKDEFAYARPYESLAELQAALDEWLHHYNHHRPHSALGGKTPAERF 283
rve_3 pfam13683
Integrase core domain;
324-389 1.61e-19

Integrase core domain;


Pssm-ID: 433402 [Multi-domain]  Cd Length: 67  Bit Score: 81.88  E-value: 1.61e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1253028337 324 GLEPKHTAVRSPESNGMAESFVKTMKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSP 389
Cdd:pfam13683   2 GIEISYIAPGKPMQNGLVESFNGTLRDECLNEHLFSSLAEARALLAAWREDYNTERPHSSLGYRTP 67
HTH_Tnp_1 pfam01527
Transposase; Transposase proteins are necessary for efficient DNA transposition. This family ...
 8-87 5.56e-14

Transposase; Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.


Pssm-ID: 426308 [Multi-domain]  Cd Length: 75  Bit Score: 66.61  E-value: 5.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337   8 EKRRRRSVQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAageqvvpASELASAMKQIKELQRLL 87
Cdd:pfam01527   2 KKRRRFSEEFKLRAVKEVLEPGRTVKEVARRHGVSPNTLYQWRRQYEGGMGASPA-------RPRLTALEEENRRLKREL 74
 
Name Accession Description Interval E-value
PRK09409 PRK09409
IS2 transposase TnpB; Reviewed
 109-400 3.51e-178

IS2 transposase TnpB; Reviewed


Pssm-ID: 181829 [Multi-domain]  Cd Length: 301  Bit Score: 498.09  E-value: 3.51e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 109 VDSARALVAGGWRISLVSRCLRVSRAQLHAMARRSKGWQDRRCKRKPDDTEALARIHTVIDDLPTYGYRRVWALLRRQSE 188
Cdd:PRK09409    1 MDSARALIARGWGVSLVSRCLRVSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 189 TDDMAVINAKRVYRIMRQNALLLERKPAIPPSKRAHRGKVAVGESNQRWCSDGFEFSCDNGEKLRVTFALDCCDREALHW 268
Cdd:PRK09409   81 LDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHW 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 269 AASTGGYDSETVQDVMLGAVERRFGNRLPTSPVEWLTDNGSAYRSHQTRQFARMVGLEPKHTAVRSPESNGMAESFVKTM 348
Cdd:PRK09409  161 AVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1253028337 349 KRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRRRTSNG 400
Cdd:PRK09409  241 KRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNG 292
PRK14702 PRK14702
insertion element IS2 transposase InsD; Provisional
 148-400 2.73e-157

insertion element IS2 transposase InsD; Provisional


Pssm-ID: 237792 [Multi-domain]  Cd Length: 262  Bit Score: 443.40  E-value: 2.73e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 148 DRRCKRKPDDTEALARIHTVIDDLPTYGYRRVWALLRRQSETDDMAVINAKRVYRIMRQNALLLERKPAIPPSKRAHRGK 227
Cdd:PRK14702    1 DGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRLMRQNALLLERKPAVPPSKRAHTGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 228 VAVGESNQRWCSDGFEFSCDNGEKLRVTFALDCCDREALHWAASTGGYDSETVQDVMLGAVERRFGNRLPTSPVEWLTDN 307
Cdd:PRK14702   81 VAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 308 GSAYRSHQTRQFARMVGLEPKHTAVRSPESNGMAESFVKTMKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYR 387
Cdd:PRK14702  161 GSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYR 240

                         250
                  ....*....|...
gi 1253028337 388 SPREYLRRRTSNG 400
Cdd:PRK14702  241 SPREYLRQRACNG 253
transpos_IS3 NF033516
IS3 family transposase;
16-392 2.11e-100

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 302.56  E-value: 2.11e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337  16 QEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAaGEQVVPaseLASAMKQIKELQRLLGKKTMENE 95
Cdd:NF033516    1 EFKLEAVREVLEGGKSVAEVARELGISPSTLYRWRKKYRGGGEAADA-GRLKEL---LTPEEEENRRLKRELAELRLENE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337  96 LLKEAVEYGRP-KKVDSARALvAGGWRISLVSRCLRVSRAQLHAMARRskgwqdRRCKRKPDDTEALARIHTVIDDLP-T 173
Cdd:NF033516   77 ILKKARKLLRPaVKYALIDAL-RGEYSVRRACRVLGVSRSTYYYWRKR------PPSRRAPDDAELRARIREIFEESRgR 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 174 YGYRRVWALLRRQSEtddmaVINAKRVYRIMRQNALLLERKPAIPP--SKRAHRGKVA---------VGESNQRWCSDGF 242
Cdd:NF033516  150 YGYRRITALLRREGI-----RVNHKRVYRLMRELGLLARRRRKRRPytTDSGHVHPVApnllnrqftATRPNQVWVTDIT 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 243 EFSCDNGeKLRVTFALDCCDREALHWAASTGgYDSETVQDVMLGAVERRfgnRLPtSPVEWLTDNGSAYRSHQTRQFARM 322
Cdd:NF033516  225 YIRTAEG-WLYLAVVLDLFSREIVGWSVSTS-MSAELVLDALEMAIEWR---GKP-EGLILHSDNGSQYTSKAYREWLKE 298

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 323 VGLEPKHTAVRSPESNGMAESFVKTMKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREY 392
Cdd:NF033516  299 HGITQSMSRPGNCWDNAVAESFFGTLKRECLYRRRFRTLEEARQAIEEYIEFYNHERPHSSLGYLTPAEF 368
PRK09413 PRK09413
IS2 repressor TnpA; Reviewed
 1-118 8.04e-64

IS2 repressor TnpA; Reviewed


Pssm-ID: 181833  Cd Length: 121  Bit Score: 200.41  E-value: 8.04e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337   1 MIDVLGPEKRRRRSVQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELASAMKQI 80
Cdd:PRK09413    1 MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQI 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1253028337  81 KELQRLLGKKTMENELLKEAVEYGRPKKVDSARALVAG 118
Cdd:PRK09413   81 KELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPG 118
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
82-399 1.85e-57

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 190.36  E-value: 1.85e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337  82 ELQRLLGKKTMENELLKEAVEYGRPKKVDSARALVAGGWRISLVSRCLRVSRAQLHAMARRSKGWqdrrckRKPDDTEAL 161
Cdd:COG2801     1 ELAEEEELRKEEELLRRLLLLLRLLLLRRRVLRRVSRRRRRLLRLLRRRRARSRRRRRLRRPRSY------RADEDAELL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 162 ARIHTVIDDLPTYGYRRVWALLRRQSETddmavINAKRVYRIMRQNALLLE-RKPAIPPSKRAHRGKVA------VGESN 234
Cdd:COG2801    75 ERIKEIFAESPRYGYRRITAELRREGIA-----VNRKRVRRLMRELGLQARrRRKKKYTTYSGHGGPIApnllftATAPN 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 235 QRWCSDGFEFSCDNGeKLRVTFALDCCDREALHWAASTGGyDSETVQDVMLGAVERRFgnrlPTSPVEWLTDNGSAYRSH 314
Cdd:COG2801   150 QVWVTDITYIPTAEG-WLYLAAVIDLFSREIVGWSVSDSM-DAELVVDALEMAIERRG----PPKPLILHSDNGSQYTSK 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 315 QTRQFARMVGLEPKHTAVRSPESNGMAESFVKTMKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLR 394
Cdd:COG2801   224 AYQELLKKLGITQSMSRPGNPQDNAFIESFFGTLKYELLYRRRFESLEEAREAIEEYIEFYNHERPHSSLGYLTPAEYEK 303


                  ....*
gi 1253028337 395 RRTSN 399
Cdd:COG2801   304 QLAAA 308
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
7-103 1.28e-20

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 85.75  E-value: 1.28e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337   7 PEKRRRRSVQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASElasamkQIKELQRL 86
Cdd:COG2963     2 SKKRRRYSPEFKAEAVRLVLEGGASVAEVARELGISPSTLYRWVRQYREGGLGGFPGDGRTTPEQA------EIRRLRKE 75

                          90
                  ....*....|....*..
gi 1253028337  87 LGKKTMENELLKEAVEY 103
Cdd:COG2963    76 LRRLEMENDILKKAAAL 92
transpos_IS481 NF033577
IS481 family transposase; null
 112-393 2.13e-20

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 90.34  E-value: 2.13e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 112 ARALVAGGWRISLVSRCLRVSRAQLHAMARRSK-----GWQDR--RCKRKPD--DTEALARIHTVIDDLpTYGYRRVWAL 182
Cdd:NF033577    6 VRLVLEDGWSVREAARRFGISRKTVYKWLKRYRaggeeGLIDRsrRPHRSPRrtSPETEARILALRREL-RLGPRRIAYE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 183 LRRQSETddmavINAKRVYRIMRQNAL--LLERKPAIPPSKRAHRGKvavgeSNQRWCSDGFEFS--CDNGeKLRVTFAL 258
Cdd:NF033577   85 LERQGPG-----VSRSTVHRILRRHGLsrLRALDRKTGKVKRYERAH-----PGELWHIDIKKLGriPDVG-RLYLHTAI 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 259 DCCDREALHWAastggYDSETVQDVMlGAVERRFgNRLPTSPVEWLTDNGSAYRSHQT--RQFARMVGLEPKHTAVRSPE 336
Cdd:NF033577  154 DDHSRFAYAEL-----YPDETAETAA-DFLRRAF-AEHGIPIRRVLTDNGSEFRSRAHgfELALAELGIEHRRTRPYHPQ 226

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1253028337 337 SNGMAESFVKTMKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYL 393
Cdd:NF033577  227 TNGKVERFHRTLKDEFAYARPYESLAELQAALDEWLHHYNHHRPHSALGGKTPAERF 283
rve_3 pfam13683
Integrase core domain;
324-389 1.61e-19

Integrase core domain;


Pssm-ID: 433402 [Multi-domain]  Cd Length: 67  Bit Score: 81.88  E-value: 1.61e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1253028337 324 GLEPKHTAVRSPESNGMAESFVKTMKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSP 389
Cdd:pfam13683   2 GIEISYIAPGKPMQNGLVESFNGTLRDECLNEHLFSSLAEARALLAAWREDYNTERPHSSLGYRTP 67
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
 233-335 2.25e-19

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 2.25e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 233 SNQRWCSDGFEFSCDNGE-KLRVTFALDCCDREALHWAASTGGyDSETVQDVMLGAVERRFGnrlptSPVEWLTDNGSAY 311
Cdd:pfam00665   1 PNQLWQGDFTYIRIPGGGgKLYLLVIVDDFSREILAWALSSEM-DAELVLDALERAIAFRGG-----VPLIIHSDNGSEY 74

                          90       100
                  ....*....|....*....|....
gi 1253028337 312 RSHQTRQFARMVGLEPKHTAVRSP 335
Cdd:pfam00665  75 TSKAFREFLKDLGIKPSFSRPGNP 98
PHA02517 PHA02517
putative transposase OrfB; Reviewed
 129-391 4.48e-14

putative transposase OrfB; Reviewed


Pssm-ID: 222853 [Multi-domain]  Cd Length: 277  Bit Score: 71.82  E-value: 4.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 129 LRVSRAQLHAMARRsKGWQDRRCKRKPDDTEALARIHTVIDD-LPTYGYRRVWALLRRQSETddmavINAKRVYRIMRQN 207
Cdd:PHA02517    1 LGIAPSTYYRCQQQ-RHHPDKRRARAQHDDWLKSEILRVYDEnHQVYGVRKVWRQLNREGIR-----VARCTVGRLMKEL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 208 ALlleRKPAIPPSKRAHRGKVAVG------------ESNQRWCSDGFEFSCDNGEkLRVTFALDCCDREALHWAAStggy 275
Cdd:PHA02517   75 GL---AGVLRGKKVRTTISRKAVAapdrvnrqfvatRPNQLWVADFTYVSTWQGW-VYVAFIIDVFARRIVGWRVS---- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337 276 dSETVQDVMLGAVERRFGNRLPTSPVEWLTDNGSAYRSHQTRQFARMVGLEPKHTAVRSPESNGMAESFVKTMKRDYISI 355
Cdd:PHA02517  147 -SSMDTDFVLDALEQALWARGRPGGLIHHSDKGSQYVSLAYTQRLKEAGIRASTGSRGDSYDNAPAESINGLYKAEVIHR 225

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1253028337 356 MPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPRE 391
Cdd:PHA02517  226 VSWKNREEVELATLEWVAWYNNRRLHERLGYTPPAE 261
HTH_Tnp_1 pfam01527
Transposase; Transposase proteins are necessary for efficient DNA transposition. This family ...
 8-87 5.56e-14

Transposase; Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.


Pssm-ID: 426308 [Multi-domain]  Cd Length: 75  Bit Score: 66.61  E-value: 5.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1253028337   8 EKRRRRSVQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAageqvvpASELASAMKQIKELQRLL 87
Cdd:pfam01527   2 KKRRRFSEEFKLRAVKEVLEPGRTVKEVARRHGVSPNTLYQWRRQYEGGMGASPA-------RPRLTALEEENRRLKREL 74
HTH_21 pfam13276
HTH-like domain; This domain contains a predicted helix-turn-helix suggesting a DNA-binding ...
 155-210 4.33e-08

HTH-like domain; This domain contains a predicted helix-turn-helix suggesting a DNA-binding function.


Pssm-ID: 463824 [Multi-domain]  Cd Length: 60  Bit Score: 49.49  E-value: 4.33e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1253028337 155 PDDTEALARIHTVIDD-LPTYGYRRVWALLRRQSEtddmAVINAKRVYRIMRQNALL 210
Cdd:pfam13276   1 ELEDELLEAIREIFEEsRGTYGYRRITAELRREGG----IRVNRKRVARLMRELGLR 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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