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Conserved domains on  [gi|1296614729|ref|WP_100778038|]
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MULTISPECIES: FliM/FliN family flagellar motor switch protein [Lelliottia]

Protein Classification

flagellar motor switch protein FliM( domain architecture ID 1005727)

flagellar motor switch protein FliM is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring) located at the base of the basal body

CATH:  3.40.1550.10
Gene Ontology:  GO:0003774|GO:0006935|GO:0071973
PubMed:  19081534

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FliM super family cl34368
Flagellar motor switch protein FliM [Cell motility];
191-269 2.82e-06

Flagellar motor switch protein FliM [Cell motility];


The actual alignment was detected with superfamily member COG1868:

Pssm-ID: 441473 [Multi-domain]  Cd Length: 326  Bit Score: 47.85  E-value: 2.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296614729 191 MLMNLRDPLTDSHAGPKPTPDRSQIERLFYSL---PLKLSGKVASLNLTVAQLAKIKPGDIIP--MSINDPVPVYIGKEQ 265
Cdd:COG1868   221 TLEPIRDKLSSRFQSDRKERDERWRERLREELeeaEVELSAELGETEITLRELLNLKVGDVIPldKKVDDPLTVYVGGVP 300


                  ....
gi 1296614729 266 IFDA 269
Cdd:COG1868   301 KFEG 304
 
Name Accession Description Interval E-value
FliM COG1868
Flagellar motor switch protein FliM [Cell motility];
191-269 2.82e-06

Flagellar motor switch protein FliM [Cell motility];


Pssm-ID: 441473 [Multi-domain]  Cd Length: 326  Bit Score: 47.85  E-value: 2.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296614729 191 MLMNLRDPLTDSHAGPKPTPDRSQIERLFYSL---PLKLSGKVASLNLTVAQLAKIKPGDIIP--MSINDPVPVYIGKEQ 265
Cdd:COG1868   221 TLEPIRDKLSSRFQSDRKERDERWRERLREELeeaEVELSAELGETEITLRELLNLKVGDVIPldKKVDDPLTVYVGGVP 300


                  ....
gi 1296614729 266 IFDA 269
Cdd:COG1868   301 KFEG 304
FliMN_C pfam01052
Type III flagellar switch regulator (C-ring) FliN C-term; This family includes the C-terminal ...
 224-267 2.26e-05

Type III flagellar switch regulator (C-ring) FliN C-term; This family includes the C-terminal region of flagellar motor switch proteins FliN and FliM. It is associated with family FliM, pfam02154 and family FliN_N pfam16973.


Pssm-ID: 460043 [Multi-domain]  Cd Length: 66  Bit Score: 41.56  E-value: 2.26e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1296614729 224 LKLSGKVASLNLTVAQLAKIKPGDIIP--MSINDPVPVYIGKEQIF 267
Cdd:pfam01052   1 VELSAELGRTTLTLRELLNLKVGDVIPldKPADEPVDVLVNGKPKF 46
fliM PRK06666
flagellar motor switch protein FliM; Validated
 223-269 2.60e-03

flagellar motor switch protein FliM; Validated


Pssm-ID: 235849 [Multi-domain]  Cd Length: 337  Bit Score: 38.67  E-value: 2.60e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1296614729 223 PLKLSGKVASLNLTVAQLAKIKPGDIIP--MSINDPVPVYIGKEQIFDA 269
Cdd:PRK06666  259 EVELVAELGEIKLTLSEILNLKVGDVIPleKPADDPLIVYVDGKPKFLC 307
SpaO_YscQ TIGR02551
type III secretion system apparatus protein YscQ/HrcQ; Genes in this family are found in type ...
 222-261 9.27e-03

type III secretion system apparatus protein YscQ/HrcQ; Genes in this family are found in type III secretion operons. The gene (YscQ) in Yersinia is essential for YOPs secretion, while SpaO in Shigella is involved in the Surface Presentation of Antigens apparatus found on the virulence plasmid, and HrcQ is involved in the Harpin secretory system in organisms like Pseudomonas syringae. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 274196 [Multi-domain]  Cd Length: 298  Bit Score: 37.00  E-value: 9.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1296614729 222 LPLKLSGKVASLNLTVAQLAKIKPGDIIPMSINDPVPVYI 261
Cdd:TIGR02551 233 LPVTLEFELGRLTLTLAELAALQPGSVLELNVPVDGPVRL 272
 
Name Accession Description Interval E-value
FliM COG1868
Flagellar motor switch protein FliM [Cell motility];
191-269 2.82e-06

Flagellar motor switch protein FliM [Cell motility];


Pssm-ID: 441473 [Multi-domain]  Cd Length: 326  Bit Score: 47.85  E-value: 2.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1296614729 191 MLMNLRDPLTDSHAGPKPTPDRSQIERLFYSL---PLKLSGKVASLNLTVAQLAKIKPGDIIP--MSINDPVPVYIGKEQ 265
Cdd:COG1868   221 TLEPIRDKLSSRFQSDRKERDERWRERLREELeeaEVELSAELGETEITLRELLNLKVGDVIPldKKVDDPLTVYVGGVP 300


                  ....
gi 1296614729 266 IFDA 269
Cdd:COG1868   301 KFEG 304
FliMN_C pfam01052
Type III flagellar switch regulator (C-ring) FliN C-term; This family includes the C-terminal ...
 224-267 2.26e-05

Type III flagellar switch regulator (C-ring) FliN C-term; This family includes the C-terminal region of flagellar motor switch proteins FliN and FliM. It is associated with family FliM, pfam02154 and family FliN_N pfam16973.


Pssm-ID: 460043 [Multi-domain]  Cd Length: 66  Bit Score: 41.56  E-value: 2.26e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1296614729 224 LKLSGKVASLNLTVAQLAKIKPGDIIP--MSINDPVPVYIGKEQIF 267
Cdd:pfam01052   1 VELSAELGRTTLTLRELLNLKVGDVIPldKPADEPVDVLVNGKPKF 46
FliN COG1886
Flagellar motor switch/type III secretory pathway protein FliN [Cell motility, Intracellular ...
 201-262 5.02e-05

Flagellar motor switch/type III secretory pathway protein FliN [Cell motility, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441490 [Multi-domain]  Cd Length: 172  Bit Score: 43.07  E-value: 5.02e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1296614729 201 DSHAGPKPTPDRSQIERLFYSLPLKLSGKVASLNLTVAQLAKIKPGDIIPM--SINDPVPVYIG 262
Cdd:COG1886    84 EPLEDAPEAEEEPENLDLLLDVPVEVTVELGRTRLTLRELLKLGPGSVIELdrLAGEPVDILVN 147
fliM PRK06666
flagellar motor switch protein FliM; Validated
 223-269 2.60e-03

flagellar motor switch protein FliM; Validated


Pssm-ID: 235849 [Multi-domain]  Cd Length: 337  Bit Score: 38.67  E-value: 2.60e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1296614729 223 PLKLSGKVASLNLTVAQLAKIKPGDIIP--MSINDPVPVYIGKEQIFDA 269
Cdd:PRK06666  259 EVELVAELGEIKLTLSEILNLKVGDVIPleKPADDPLIVYVDGKPKFLC 307
SpaO_YscQ TIGR02551
type III secretion system apparatus protein YscQ/HrcQ; Genes in this family are found in type ...
 222-261 9.27e-03

type III secretion system apparatus protein YscQ/HrcQ; Genes in this family are found in type III secretion operons. The gene (YscQ) in Yersinia is essential for YOPs secretion, while SpaO in Shigella is involved in the Surface Presentation of Antigens apparatus found on the virulence plasmid, and HrcQ is involved in the Harpin secretory system in organisms like Pseudomonas syringae. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 274196 [Multi-domain]  Cd Length: 298  Bit Score: 37.00  E-value: 9.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1296614729 222 LPLKLSGKVASLNLTVAQLAKIKPGDIIPMSINDPVPVYI 261
Cdd:TIGR02551 233 LPVTLEFELGRLTLTLAELAALQPGSVLELNVPVDGPVRL 272
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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