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Conserved domains on  [gi|1330528344|ref|WP_102470919|]
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MULTISPECIES: Sec-independent protein translocase protein TatB [unclassified Vibrio]

Protein Classification

Sec-independent protein translocase subunit TatB( domain architecture ID 10019022)

Sec-independent protein translocase subunit TatB, together with TatC, forms the binding site that directly interacts with Tat signal peptides within the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tatB TIGR01410
twin arginine-targeting protein translocase TatB; This model represents the TatB protein of a ...
 2-81 3.33e-34

twin arginine-targeting protein translocase TatB; This model represents the TatB protein of a Sec-independent system for transporting folded proteins, often with a bound redox cofactor, across the bacterial inner membrane. TatC is the multiple membrane spanning component. TatB, like the related TatA/E proteins, appears to span the membrane one time. The tat system recognizes proteins with an elongated signal sequence containing a conserved R-R in a motif approximated by RRxFLK N-terminal to the transmembrane helix. TIGRFAMs model TIGR01409 describes this twin-Arg signal sequence. A similar system, termed Delta-pH-dependent transport, operates on chloroplast-encoded proteins. [Protein fate, Protein and peptide secretion and trafficking]


:

Pssm-ID: 130477 [Multi-domain]  Cd Length: 80  Bit Score: 113.56  E-value: 3.33e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330528344   2 FDIGFWELVLISVVGLVVLGPERLPTAIRSVSRFISSAKSMANNVKDELSHELKVQELQDNLRKAEKMGMEDLSPELKSS 81
Cdd:TIGR01410   1 FDIGFSELLLIAVVALVVLGPERLPVAIRTVGGFVRALRGMASDVKNELDEELKLQELDDQLKKAQQARFLNLTAELKDS 80
 
Name Accession Description Interval E-value
tatB TIGR01410
twin arginine-targeting protein translocase TatB; This model represents the TatB protein of a ...
 2-81 3.33e-34

twin arginine-targeting protein translocase TatB; This model represents the TatB protein of a Sec-independent system for transporting folded proteins, often with a bound redox cofactor, across the bacterial inner membrane. TatC is the multiple membrane spanning component. TatB, like the related TatA/E proteins, appears to span the membrane one time. The tat system recognizes proteins with an elongated signal sequence containing a conserved R-R in a motif approximated by RRxFLK N-terminal to the transmembrane helix. TIGRFAMs model TIGR01409 describes this twin-Arg signal sequence. A similar system, termed Delta-pH-dependent transport, operates on chloroplast-encoded proteins. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 130477 [Multi-domain]  Cd Length: 80  Bit Score: 113.56  E-value: 3.33e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330528344   2 FDIGFWELVLISVVGLVVLGPERLPTAIRSVSRFISSAKSMANNVKDELSHELKVQELQDNLRKAEKMGMEDLSPELKSS 81
Cdd:TIGR01410   1 FDIGFSELLLIAVVALVVLGPERLPVAIRTVGGFVRALRGMASDVKNELDEELKLQELDDQLKKAQQARFLNLTAELKDS 80
TatA COG1826
Twin-arginine protein secretion pathway components TatA and TatB [Intracellular trafficking, ...
 1-68 1.15e-20

Twin-arginine protein secretion pathway components TatA and TatB [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441431 [Multi-domain]  Cd Length: 72  Bit Score: 79.21  E-value: 1.15e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1330528344   1 MFDIGFWELVLISVVGLVVLGPERLPTAIRSVSRFISSAKSMANNVKDELSHELKVQELQDNLRKAEK 68
Cdd:COG1826     1 MFGIGFWELLIILVVALLVFGPKKLPELARSLGKAIREFKKAANEVKEELDEELKEEELRKSEKEAEE 68
PRK04654 PRK04654
sec-independent translocase; Provisional
 1-92 8.19e-18

sec-independent translocase; Provisional


Pssm-ID: 135173 [Multi-domain]  Cd Length: 214  Bit Score: 75.62  E-value: 8.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330528344   1 MFDIGFWELVLISVVGLVVLGPERLPTAIRSVSRFISSAKSMANNVKDELSHELKVQELqdnlrkaeKMGMEDLSPELKS 80
Cdd:PRK04654    1 MFDIGVGELTLIAVVALVVLGPERLPKAARFAGLWVRRARMQWDSVKQELERELEAEEL--------KRSLQDVQASLRE 72

                          90
                  ....*....|..
gi 1330528344  81 SVEELKRAAQDV 92
Cdd:PRK04654   73 AEDQLRNTQQQV 84
TatA_B_E pfam02416
mttA/Hcf106 family; Members of this protein family are involved in a sec independent ...
 4-53 6.21e-05

mttA/Hcf106 family; Members of this protein family are involved in a sec independent translocation mechanism. This pathway has been called the DeltapH pathway in chloroplasts. Members of this family in E.coli are involved in export of redox proteins with a "twin arginine" leader motif.


Pssm-ID: 426762  Cd Length: 53  Bit Score: 38.06  E-value: 6.21e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1330528344   4 IGFWELVLISVVGLVVLGPERLPTAIRSVSRFISSAKSMANNVKDELSHE 53
Cdd:pfam02416   1 LGIPELLIILVVALLLFGPKKLPELGRALGKTLREFKKATKELEEEDEKE 50
 
Name Accession Description Interval E-value
tatB TIGR01410
twin arginine-targeting protein translocase TatB; This model represents the TatB protein of a ...
 2-81 3.33e-34

twin arginine-targeting protein translocase TatB; This model represents the TatB protein of a Sec-independent system for transporting folded proteins, often with a bound redox cofactor, across the bacterial inner membrane. TatC is the multiple membrane spanning component. TatB, like the related TatA/E proteins, appears to span the membrane one time. The tat system recognizes proteins with an elongated signal sequence containing a conserved R-R in a motif approximated by RRxFLK N-terminal to the transmembrane helix. TIGRFAMs model TIGR01409 describes this twin-Arg signal sequence. A similar system, termed Delta-pH-dependent transport, operates on chloroplast-encoded proteins. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 130477 [Multi-domain]  Cd Length: 80  Bit Score: 113.56  E-value: 3.33e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330528344   2 FDIGFWELVLISVVGLVVLGPERLPTAIRSVSRFISSAKSMANNVKDELSHELKVQELQDNLRKAEKMGMEDLSPELKSS 81
Cdd:TIGR01410   1 FDIGFSELLLIAVVALVVLGPERLPVAIRTVGGFVRALRGMASDVKNELDEELKLQELDDQLKKAQQARFLNLTAELKDS 80
TatA COG1826
Twin-arginine protein secretion pathway components TatA and TatB [Intracellular trafficking, ...
 1-68 1.15e-20

Twin-arginine protein secretion pathway components TatA and TatB [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441431 [Multi-domain]  Cd Length: 72  Bit Score: 79.21  E-value: 1.15e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1330528344   1 MFDIGFWELVLISVVGLVVLGPERLPTAIRSVSRFISSAKSMANNVKDELSHELKVQELQDNLRKAEK 68
Cdd:COG1826     1 MFGIGFWELLIILVVALLVFGPKKLPELARSLGKAIREFKKAANEVKEELDEELKEEELRKSEKEAEE 68
PRK04654 PRK04654
sec-independent translocase; Provisional
 1-92 8.19e-18

sec-independent translocase; Provisional


Pssm-ID: 135173 [Multi-domain]  Cd Length: 214  Bit Score: 75.62  E-value: 8.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330528344   1 MFDIGFWELVLISVVGLVVLGPERLPTAIRSVSRFISSAKSMANNVKDELSHELKVQELqdnlrkaeKMGMEDLSPELKS 80
Cdd:PRK04654    1 MFDIGVGELTLIAVVALVVLGPERLPKAARFAGLWVRRARMQWDSVKQELERELEAEEL--------KRSLQDVQASLRE 72

                          90
                  ....*....|..
gi 1330528344  81 SVEELKRAAQDV 92
Cdd:PRK04654   73 AEDQLRNTQQQV 84
PRK01371 PRK01371
Sec-independent protein translocase protein TatB;
1-76 1.61e-13

Sec-independent protein translocase protein TatB;


Pssm-ID: 179287 [Multi-domain]  Cd Length: 137  Bit Score: 62.42  E-value: 1.61e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1330528344   1 MFDIGFWELVLISVVGLVVLGPERLPTAIRSVSRFISSAKSMANNVKDELSHELKvQELQDnlrkaekMGMEDLSP 76
Cdd:PRK01371    1 MFGIGPGELVVLVVLAVLVFGPDKLPKAARDAGRTLRQLREMANNARNDLRSELG-PEFAD-------LDLRDLNP 68
tatA PRK14858
twin arginine translocase protein A; Provisional
 1-109 1.14e-09

twin arginine translocase protein A; Provisional


Pssm-ID: 184860  Cd Length: 108  Bit Score: 51.79  E-value: 1.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330528344   1 MFDIGFWELVLISVVGLVVLGPERLPTAIRSVSRFISSAKSMANNVKDELSHELKVQELQDNLRKAEKMGMEDLSPELKS 80
Cdd:PRK14858    1 MFGIGMPELIVILVIALIVIGPQKLPDLARSLGRGLAEFKKATDDFKQSMQEESRTAEEKEKAEKLAETKKEAEAPEAKA 80

                          90       100
                  ....*....|....*....|....*....
gi 1330528344  81 SvEELKRAAQDVTRPYAKDKVETTEEASS 109
Cdd:PRK14858   81 E-EDQAPKPKGAGEPPATVASKAGDGAKA 108
tatB PRK00182
Sec-independent protein translocase subunit TatB;
1-54 1.23e-08

Sec-independent protein translocase subunit TatB;


Pssm-ID: 234681  Cd Length: 160  Bit Score: 50.21  E-value: 1.23e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1330528344   1 MF-DIGFWELVLISVVGLVVLGPERLPTAIRSVSRFISSAKSMANNVKDELSHEL 54
Cdd:PRK00182    1 MFsSVGWGEILLLLIVGLIVIGPERLPRLIEDVRAALLAARTAINNAKQQLDGDF 55
tatA PRK14861
twin arginine translocase protein A; Provisional
 1-58 4.85e-06

twin arginine translocase protein A; Provisional


Pssm-ID: 237837  Cd Length: 61  Bit Score: 41.11  E-value: 4.85e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1330528344   1 MFDIGFWELVLISVVGLVVLGPERLPTAIRSVSRFISSAKSMANNVKDELSHELKVQE 58
Cdd:PRK14861    2 FSNIGFPGLILILVVALIIFGPKKLPELGKALGKTLREFKKATKELTDDDFQEKKKKE 59
TatA_B_E pfam02416
mttA/Hcf106 family; Members of this protein family are involved in a sec independent ...
 4-53 6.21e-05

mttA/Hcf106 family; Members of this protein family are involved in a sec independent translocation mechanism. This pathway has been called the DeltapH pathway in chloroplasts. Members of this family in E.coli are involved in export of redox proteins with a "twin arginine" leader motif.


Pssm-ID: 426762  Cd Length: 53  Bit Score: 38.06  E-value: 6.21e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1330528344   4 IGFWELVLISVVGLVVLGPERLPTAIRSVSRFISSAKSMANNVKDELSHE 53
Cdd:pfam02416   1 LGIPELLIILVVALLLFGPKKLPELGRALGKTLREFKKATKELEEEDEKE 50
tatA PRK00575
Sec-independent protein translocase subunit TatA;
1-49 6.98e-05

Sec-independent protein translocase subunit TatA;


Pssm-ID: 234797 [Multi-domain]  Cd Length: 92  Bit Score: 38.95  E-value: 6.98e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1330528344   1 MFDIGFWELVLISVVGLVVLGPERLPTAIRSVSR----FISSAKSMANNVKDE 49
Cdd:PRK00575    1 MGSLSPWHWAILAVVVILLFGAKKLPDAARSLGKslriFKSEVKEMQSDNKAE 53
tatAE TIGR01411
twin arginine-targeting protein translocase, TatA/E family; This model distinguishes TatA/E ...
 4-49 7.25e-05

twin arginine-targeting protein translocase, TatA/E family; This model distinguishes TatA/E from the related TatB, but does not distinguish TatA from TatE. The Tat (twin-arginine translocation) system is a Sec-independent exporter for folded proteins, often with a redox cofactor already bound, across the bacterial inner membrane. Functionally equivalent systems are found in the chloroplast and some in archaeal species. The signal peptide recognized by the Tat system is modeled by TIGR01409. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273605 [Multi-domain]  Cd Length: 47  Bit Score: 37.97  E-value: 7.25e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1330528344   4 IGFWELVLISVVGLVVLGPERLPTAIRSVSRFISSAKSMANNVKDE 49
Cdd:TIGR01411   2 LSPPEWLIILVVILLLFGAKKLPELGRDLGKAIKEFKKALKEEEDE 47
tatA PRK14857
TatA/E family twin arginine-targeting protein translocase;
2-84 3.70e-04

TatA/E family twin arginine-targeting protein translocase;


Pssm-ID: 184859  Cd Length: 90  Bit Score: 37.01  E-value: 3.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1330528344   2 FDIGFWELVLISVVGLVVLGPERLPTAIRSVSRFISSAKSMANNVKDELSHELKVQELQDNLRKA-EKMGMEDLSPELKS 80
Cdd:PRK14857    4 FGIGLPEMAVILVIALLVFGPKKLPEIGRSLGKTLKGFQEASKEFENEIKREMAEPEQEVKAPAElESNQTNEANQEQVD 83


                  ....
gi 1330528344  81 SVEE 84
Cdd:PRK14857   84 AENS 87
tatA PRK00191
twin arginine translocase protein A; Provisional
 3-45 1.28e-03

twin arginine translocase protein A; Provisional


Pssm-ID: 234683 [Multi-domain]  Cd Length: 84  Bit Score: 35.32  E-value: 1.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1330528344   3 DIGFWELVLISVVGLVVLGPERLPTAIRSVSR----FISSAKSMANN 45
Cdd:PRK00191    2 SLGPWEIGIIVLLIIVLFGAKKLPDAARSIGRsmriFKSEVKEMSKD 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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