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Conserved domains on  [gi|1371757627|ref|WP_106702458|]
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tautomerase family protein [Ottowia oryzae]

Protein Classification

tautomerase family protein( domain architecture ID 10216049)

tautomerase family protein similar to Bacillus subtilis tautomerases YusQ and YolI

CATH:  3.30.429.10
Gene Ontology:  GO:0016853
PubMed:  29184004|12051677|18695941
SCOP:  3001770

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tautomerase_2 pfam14552
Tautomerase enzyme;
38-111 1.68e-21

Tautomerase enzyme;


:

Pssm-ID: 434035  Cd Length: 82  Bit Score: 81.46  E-value: 1.68e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371757627  38 DRQIRYVEHRPEHFSVPAT-----KSENYTYVEIVMFPGRSLAAKRQLYQEIVTRFQA-LGIDPQDVLIVLQEPPLSNWG 111
Cdd:pfam14552   1 DRFQIIHEHDPEDFVYPPTylgieRSDDYVIIQITLFAGRSVEQKKALYRALAERLAAkLGIRPEDVFIVLVENPKENWS 80
4Oxalocrotonate_Tautomerase super family cl00235
4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The ...
 2-53 2.65e-03

4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one dimer and the third from a neighboring monomer. Each monomer is a beta-alpha-beta fold with two small beta strands at the C-terminus that fold back on themselves. A pair of monomers form a dimer with two-fold symmetry, consisting of a 4-stranded beta sheet with two helices on one side and two additional small beta strands at each end. The dimers are assembled around a 3-fold axis of rotation to form a hexamer, with the short beta strands from each dimer contacting the neighboring dimers.


The actual alignment was detected with superfamily member pfam01361:

Pssm-ID: 444774  Cd Length: 60  Bit Score: 34.19  E-value: 2.65e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1371757627   2 PLAKIEVRRSRPPEEVQGLMEAVYQALRTALKVPQDDRQIRYVEHRPEHFSV 53
Cdd:pfam01361   1 PFVNIKLFEGRTDEQKKELIERVTDALVEVLGAPRSAIVVIIEEVPPENWGV 52
 
Name Accession Description Interval E-value
Tautomerase_2 pfam14552
Tautomerase enzyme;
38-111 1.68e-21

Tautomerase enzyme;


Pssm-ID: 434035  Cd Length: 82  Bit Score: 81.46  E-value: 1.68e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371757627  38 DRQIRYVEHRPEHFSVPAT-----KSENYTYVEIVMFPGRSLAAKRQLYQEIVTRFQA-LGIDPQDVLIVLQEPPLSNWG 111
Cdd:pfam14552   1 DRFQIIHEHDPEDFVYPPTylgieRSDDYVIIQITLFAGRSVEQKKALYRALAERLAAkLGIRPEDVFIVLVENPKENWS 80
PptA COG1942
Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites ...
 63-119 2.40e-11

Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441545  Cd Length: 58  Bit Score: 54.77  E-value: 2.40e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1371757627  63 YVEIVMFPGRSLAAKRQLYQEIVTRF-QALGIDPQDVLIVLQEPPLSNWGLqGGQPAS 119
Cdd:COG1942     2 IINIKLFEGRTPEQKRALAKAVTDAVvEVLGKPPESVSVVIEEVPPENWGI-GGKLLS 58
4Oxalocrotonate_Tautomerase cd00491
4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The ...
 63-119 9.82e-05

4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one dimer and the third from a neighboring monomer. Each monomer is a beta-alpha-beta fold with two small beta strands at the C-terminus that fold back on themselves. A pair of monomers form a dimer with two-fold symmetry, consisting of a 4-stranded beta sheet with two helices on one side and two additional small beta strands at each end. The dimers are assembled around a 3-fold axis of rotation to form a hexamer, with the short beta strands from each dimer contacting the neighboring dimers.


Pssm-ID: 238274  Cd Length: 58  Bit Score: 37.75  E-value: 9.82e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1371757627  63 YVEIVMFPGRSLAAKRQLYQEiVTRF--QALGIDPQDVLIVLQEPPLSNWGLqGGQPAS 119
Cdd:cd00491     2 FVQIYILEGRTDEQKRELIER-VTEAvsEILGAPEATIVVIIDEMPKENWGI-GGESAS 58
PRK00745 PRK00745
4-oxalocrotonate tautomerase; Provisional
 64-114 1.02e-04

4-oxalocrotonate tautomerase; Provisional


Pssm-ID: 179107  Cd Length: 62  Bit Score: 37.78  E-value: 1.02e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1371757627  64 VEIVMFPGRSLAAKRQLYQEIvTRF--QALGIDPQDVLIVLQEPPLSNWGLQG 114
Cdd:PRK00745    4 FHIELFEGRTVEQKRKLVEEI-TRVtvETLGCPPESVDIIITDVKRENWATGG 55
Tautomerase pfam01361
Tautomerase enzyme; This family includes the enzyme 4-oxalocrotonate tautomerase that ...
 2-53 2.65e-03

Tautomerase enzyme; This family includes the enzyme 4-oxalocrotonate tautomerase that catalyzes the ketonization of 2-hydroxymuconate to 2-oxo-3-hexenedioate.


Pssm-ID: 396090  Cd Length: 60  Bit Score: 34.19  E-value: 2.65e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1371757627   2 PLAKIEVRRSRPPEEVQGLMEAVYQALRTALKVPQDDRQIRYVEHRPEHFSV 53
Cdd:pfam01361   1 PFVNIKLFEGRTDEQKKELIERVTDALVEVLGAPRSAIVVIIEEVPPENWGV 52
 
Name Accession Description Interval E-value
Tautomerase_2 pfam14552
Tautomerase enzyme;
38-111 1.68e-21

Tautomerase enzyme;


Pssm-ID: 434035  Cd Length: 82  Bit Score: 81.46  E-value: 1.68e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371757627  38 DRQIRYVEHRPEHFSVPAT-----KSENYTYVEIVMFPGRSLAAKRQLYQEIVTRFQA-LGIDPQDVLIVLQEPPLSNWG 111
Cdd:pfam14552   1 DRFQIIHEHDPEDFVYPPTylgieRSDDYVIIQITLFAGRSVEQKKALYRALAERLAAkLGIRPEDVFIVLVENPKENWS 80
PptA COG1942
Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites ...
 63-119 2.40e-11

Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441545  Cd Length: 58  Bit Score: 54.77  E-value: 2.40e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1371757627  63 YVEIVMFPGRSLAAKRQLYQEIVTRF-QALGIDPQDVLIVLQEPPLSNWGLqGGQPAS 119
Cdd:COG1942     2 IINIKLFEGRTPEQKRALAKAVTDAVvEVLGKPPESVSVVIEEVPPENWGI-GGKLLS 58
Tautomerase pfam01361
Tautomerase enzyme; This family includes the enzyme 4-oxalocrotonate tautomerase that ...
 63-114 5.71e-05

Tautomerase enzyme; This family includes the enzyme 4-oxalocrotonate tautomerase that catalyzes the ketonization of 2-hydroxymuconate to 2-oxo-3-hexenedioate.


Pssm-ID: 396090  Cd Length: 60  Bit Score: 38.43  E-value: 5.71e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1371757627  63 YVEIVMFPGRSLAAKRQLYQEIVTRF-QALGIDPQDVLIVLQEPPLSNWGLQG 114
Cdd:pfam01361   2 FVNIKLFEGRTDEQKKELIERVTDALvEVLGAPRSAIVVIIEEVPPENWGVGG 54
4Oxalocrotonate_Tautomerase cd00491
4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The ...
 63-119 9.82e-05

4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one dimer and the third from a neighboring monomer. Each monomer is a beta-alpha-beta fold with two small beta strands at the C-terminus that fold back on themselves. A pair of monomers form a dimer with two-fold symmetry, consisting of a 4-stranded beta sheet with two helices on one side and two additional small beta strands at each end. The dimers are assembled around a 3-fold axis of rotation to form a hexamer, with the short beta strands from each dimer contacting the neighboring dimers.


Pssm-ID: 238274  Cd Length: 58  Bit Score: 37.75  E-value: 9.82e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1371757627  63 YVEIVMFPGRSLAAKRQLYQEiVTRF--QALGIDPQDVLIVLQEPPLSNWGLqGGQPAS 119
Cdd:cd00491     2 FVQIYILEGRTDEQKRELIER-VTEAvsEILGAPEATIVVIIDEMPKENWGI-GGESAS 58
PRK00745 PRK00745
4-oxalocrotonate tautomerase; Provisional
 64-114 1.02e-04

4-oxalocrotonate tautomerase; Provisional


Pssm-ID: 179107  Cd Length: 62  Bit Score: 37.78  E-value: 1.02e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1371757627  64 VEIVMFPGRSLAAKRQLYQEIvTRF--QALGIDPQDVLIVLQEPPLSNWGLQG 114
Cdd:PRK00745    4 FHIELFEGRTVEQKRKLVEEI-TRVtvETLGCPPESVDIIITDVKRENWATGG 55
Tautomerase pfam01361
Tautomerase enzyme; This family includes the enzyme 4-oxalocrotonate tautomerase that ...
 2-53 2.65e-03

Tautomerase enzyme; This family includes the enzyme 4-oxalocrotonate tautomerase that catalyzes the ketonization of 2-hydroxymuconate to 2-oxo-3-hexenedioate.


Pssm-ID: 396090  Cd Length: 60  Bit Score: 34.19  E-value: 2.65e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1371757627   2 PLAKIEVRRSRPPEEVQGLMEAVYQALRTALKVPQDDRQIRYVEHRPEHFSV 53
Cdd:pfam01361   1 PFVNIKLFEGRTDEQKKELIERVTDALVEVLGAPRSAIVVIIEEVPPENWGV 52
CHMI cd00580
5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the ...
 17-91 2.98e-03

5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the homoprotocatechuate pathway, one of the microbial meta-fission pathways that degrade aromatic carbon sources to citric acid cycle intermediates. Despite the structural similarity of CHMI with 4-oxalocrotonate tautomerase (4-OT) and macrophage migration inhibitory factor (MIF), there is no significant sequence similarity among these protein families, and therefore, they are not combined in one hierarchy.


Pssm-ID: 238324 [Multi-domain]  Cd Length: 113  Bit Score: 34.85  E-value: 2.98e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1371757627  17 VQGLMEAVYQALRTALKVPQDDrqIRYVEHRPEHFSVpATKSENYTYVEIV--MFPGRSLAAKRQLYQEIVTRFQAL 91
Cdd:cd00580    17 IPELLRALHDALVASGLFPLGG--IKVRAIRADHYRV-GDGDEDDAFIHVTlrILAGRSEEQKQELSEALLAALRAH 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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