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Conserved domains on  [gi|1373511535|ref|WP_107106650|]
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MULTISPECIES: Lrp/AsnC family transcriptional regulator [Rhizobium]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
20-157 2.28e-48

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 153.01  E-value: 2.28e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1373511535  20 DRIDRHILRELSVDARQPNVRLAERVGLSPSACLRRVQELERAGVITGYRASINRARMGAGFLAYVTVGLSDHtkkSQDA 99
Cdd:COG1522     4 DEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPH---RLDE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1373511535 100 FEEAMSQADEVVECHNVTGTIEYLLRIEVADIATYKAFHTGVLGTLPQVTAITSFIVL 157
Cdd:COG1522    81 FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
20-157 2.28e-48

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 153.01  E-value: 2.28e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1373511535  20 DRIDRHILRELSVDARQPNVRLAERVGLSPSACLRRVQELERAGVITGYRASINRARMGAGFLAYVTVGLSDHtkkSQDA 99
Cdd:COG1522     4 DEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPH---RLDE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1373511535 100 FEEAMSQADEVVECHNVTGTIEYLLRIEVADIATYKAFHTGVLGTLPQVTAITSFIVL 157
Cdd:COG1522    81 FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
20-165 6.86e-36

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 122.18  E-value: 6.86e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1373511535  20 DRIDRHILRELSVDARQPNVRLAERVGLSPSACLRRVQELERAGVITGYRASINRARMGAGFLAYVTVGLsdhTKKSQDA 99
Cdd:PRK11169   13 DRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITL---NRGAPDV 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1373511535 100 FEE---AMSQADEVVECHNVTGTIEYLLRIEVADIATYKAFHTGVLGTLPQVTAITSFIVLGSPKDQRR 165
Cdd:PRK11169   90 FEQfnaAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQTNR 158
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 20-126 1.17e-34

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 117.23  E-value: 1.17e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1373511535   20 DRIDRHILRELSVDARQPNVRLAERVGLSPSACLRRVQELERAGVITGYRASINRARMGAGFLAYVTVGLsdHTKKSQDA 99
Cdd:smart00344   2 DEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTL--ENPDKLEE 79

                           90       100
                   ....*....|....*....|....*..
gi 1373511535  100 FEEAMSQADEVVECHNVTGTIEYLLRI 126
Cdd:smart00344  80 FLEKLEKLPEVEEVYLVTGDYDYLLKV 106
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
20-60 6.41e-16

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 67.39  E-value: 6.41e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1373511535  20 DRIDRHILRELSVDARQPNVRLAERVGLSPSACLRRVQELE 60
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 16-70 7.12e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 44.60  E-value: 7.12e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1373511535  16 KPVFDRIDRHILRELSvDARQPNVRLAERVGLSPSACLRRVQELERAGVITGYRA 70
Cdd:cd00090     2 KALSDPTRLRILRLLL-EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRRE 55
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
20-157 2.28e-48

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 153.01  E-value: 2.28e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1373511535  20 DRIDRHILRELSVDARQPNVRLAERVGLSPSACLRRVQELERAGVITGYRASINRARMGAGFLAYVTVGLSDHtkkSQDA 99
Cdd:COG1522     4 DEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPH---RLDE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1373511535 100 FEEAMSQADEVVECHNVTGTIEYLLRIEVADIATYKAFHTGVLGTLPQVTAITSFIVL 157
Cdd:COG1522    81 FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
20-165 6.86e-36

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 122.18  E-value: 6.86e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1373511535  20 DRIDRHILRELSVDARQPNVRLAERVGLSPSACLRRVQELERAGVITGYRASINRARMGAGFLAYVTVGLsdhTKKSQDA 99
Cdd:PRK11169   13 DRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITL---NRGAPDV 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1373511535 100 FEE---AMSQADEVVECHNVTGTIEYLLRIEVADIATYKAFHTGVLGTLPQVTAITSFIVLGSPKDQRR 165
Cdd:PRK11169   90 FEQfnaAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQTNR 158
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 20-126 1.17e-34

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 117.23  E-value: 1.17e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1373511535   20 DRIDRHILRELSVDARQPNVRLAERVGLSPSACLRRVQELERAGVITGYRASINRARMGAGFLAYVTVGLsdHTKKSQDA 99
Cdd:smart00344   2 DEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTL--ENPDKLEE 79

                           90       100
                   ....*....|....*....|....*..
gi 1373511535  100 FEEAMSQADEVVECHNVTGTIEYLLRI 126
Cdd:smart00344  80 FLEKLEKLPEVEEVYLVTGDYDYLLKV 106
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
20-60 6.41e-16

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 67.39  E-value: 6.41e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1373511535  20 DRIDRHILRELSVDARQPNVRLAERVGLSPSACLRRVQELE 60
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 87-157 8.95e-16

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 67.94  E-value: 8.95e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1373511535  87 VGLSDHTKKSQDAFEEAMSQADEVVECHNVTGTIEYLLRIEVADIATYKAFHTGVLGTLPQVTAITSFIVL 157
Cdd:pfam01037   1 VEVKLEPGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVL 71
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
21-65 2.45e-14

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 63.22  E-value: 2.45e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1373511535  21 RIDRHILRELSVDARQPNVRLAERVGLSPSACLRRVQELERAGVI 65
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 20-118 5.24e-13

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 62.80  E-value: 5.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1373511535  20 DRIDRHILRELSVDARQPNVRLAERVGLSPSACLRRVQELERAGVITGYRASINRARMGAGFLAYVTVGLsdhtkKSQDA 99
Cdd:PRK11179    8 DNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIIL-----KSAKD 82

                          90       100
                  ....*....|....*....|..
gi 1373511535 100 FEEAMS---QADEVVECHNVTG 118
Cdd:PRK11179   83 YPSALAkleSLDEVVEAYYTTG 104
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 16-70 7.12e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 44.60  E-value: 7.12e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1373511535  16 KPVFDRIDRHILRELSvDARQPNVRLAERVGLSPSACLRRVQELERAGVITGYRA 70
Cdd:cd00090     2 KALSDPTRLRILRLLL-EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRRE 55
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
24-66 8.29e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 34.17  E-value: 8.29e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1373511535  24 RHILRELSVDARQPNvRLAERVGLSPSACLRRVQELERAGVIT 66
Cdd:COG4189    22 LRILRLLAEEPLNVN-ELAEALGLPKSTVSYHIRKLEEAGLIR 63
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 26-69 8.93e-03

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 33.28  E-value: 8.93e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1373511535  26 ILRELSVDARQPNVRLAERVGLSPSACLRRVQELERAGVITGYR 69
Cdd:pfam12840  15 ILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVR 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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