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Conserved domains on  [gi|1388888345|ref|WP_108925089|]
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homoserine kinase [Actinobacillus porcitonsillarum]

Protein Classification

homoserine kinase( domain architecture ID 11479451)

homoserine kinase catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate

EC:  2.7.1.39
Gene Ontology:  GO:0016310|GO:0009088|GO:0004413|GO:0005737|GO:0005524

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK01212 PRK01212
homoserine kinase; Provisional
 1-314 5.73e-158

homoserine kinase; Provisional


:

Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 443.05  E-value: 5.73e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345   1 MTLRIYAPASSANLSVGFDSLGTAISPIDGSLLGDVVQIEDcdqPFELESVGYFVRKLPKEPQKNIVYQAYVLFSERLkl 80
Cdd:PRK01212    2 MMVKVRVPATSANLGPGFDSLGLALSLYDEVLVGDVVSVEA---EFSIEVIGEGADKLPLDPEKNLVYQAALKFLEKL-- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345  81 rgGVVKNLRLTLEKNMPIGSGLGSSACSIVAALVALNKFHDEPFSKMELLEMMGELEGrisgsiHYDNVAPCYLGGLQLM 160
Cdd:PRK01212   77 --GKPPGLRIELEKNIPLGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLATEGEG------HPDNVAPALLGGLVLA 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345 161 TQSLGNICQPIPFFDEWYWVLAYPGIEVSTAEARAILPKSYTRQDMIAQARYLGSFIHACHTRQDVLAAIMMKDLIAEPY 240
Cdd:PRK01212  149 LEENGVISVKIPVFDDLKWVVAIPNIELSTAEARAVLPKQYSLKDAVFNSSRAALLVAALYTGDYELAGRAMKDVLHEPY 228

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1388888345 241 RESLLPNFAEVRQGCKDLGALAVGISGSGPTMFAIAPDlEHAQKLVAYLEKDYLQNNEGFIHICKVDNQGAREL 314
Cdd:PRK01212  229 RAKLIPGFAEVRQAALEAGALGAGISGAGPTVFALCDK-EDAEKVADALQKAFLQGIEGFVHVLRLDTAGARVL 301
 
Name Accession Description Interval E-value
PRK01212 PRK01212
homoserine kinase; Provisional
 1-314 5.73e-158

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 443.05  E-value: 5.73e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345   1 MTLRIYAPASSANLSVGFDSLGTAISPIDGSLLGDVVQIEDcdqPFELESVGYFVRKLPKEPQKNIVYQAYVLFSERLkl 80
Cdd:PRK01212    2 MMVKVRVPATSANLGPGFDSLGLALSLYDEVLVGDVVSVEA---EFSIEVIGEGADKLPLDPEKNLVYQAALKFLEKL-- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345  81 rgGVVKNLRLTLEKNMPIGSGLGSSACSIVAALVALNKFHDEPFSKMELLEMMGELEGrisgsiHYDNVAPCYLGGLQLM 160
Cdd:PRK01212   77 --GKPPGLRIELEKNIPLGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLATEGEG------HPDNVAPALLGGLVLA 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345 161 TQSLGNICQPIPFFDEWYWVLAYPGIEVSTAEARAILPKSYTRQDMIAQARYLGSFIHACHTRQDVLAAIMMKDLIAEPY 240
Cdd:PRK01212  149 LEENGVISVKIPVFDDLKWVVAIPNIELSTAEARAVLPKQYSLKDAVFNSSRAALLVAALYTGDYELAGRAMKDVLHEPY 228

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1388888345 241 RESLLPNFAEVRQGCKDLGALAVGISGSGPTMFAIAPDlEHAQKLVAYLEKDYLQNNEGFIHICKVDNQGAREL 314
Cdd:PRK01212  229 RAKLIPGFAEVRQAALEAGALGAGISGAGPTVFALCDK-EDAEKVADALQKAFLQGIEGFVHVLRLDTAGARVL 301
thrB TIGR00191
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ...
 3-314 8.15e-149

homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 129295 [Multi-domain]  Cd Length: 302  Bit Score: 419.88  E-value: 8.15e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345   3 LRIYAPASSANLSVGFDSLGTAISPIDGSLLGDVVQIEDCDQpfELESVGYFVRKLPKEPQKNIVYQAYVLFSERLKLRG 82
Cdd:TIGR00191   1 FRVKVPASSANLGPGFDVLGAALSLYLGLTVTDVVAQESDDT--EIEAEGEGVEKIPTEPTDNLIYQVAKRFLDQLGIRM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345  83 GVVKnlrLTLEKNMPIGSGLGSSACSIVAALVALNKFHDEPFSKMELLEMMGELEGrisgsiHYDNVAPCYLGGLQLMTQ 162
Cdd:TIGR00191  79 PPVK---VTLEKNIPLGRGLGSSAAAIVAALAAANELCGLPLSKERLLDYASELEG------HPDNVAPALLGGFQLAFV 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345 163 SLG-NICQPIPFFDEWYWVLAYPGIEVSTAEARAILPKSYTRQDMIAQARYLGSFIHACHTRQDVLAAIMMKDLIAEPYR 241
Cdd:TIGR00191 150 EDDkLEVLKIPIFSKLDWVLAIPNIEVSTAEARAVLPKAYPRQDLVFNLSHLAGLVHAIYQKKPDLGAIMMKDRIHQPYR 229

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1388888345 242 ESLLPNFAEVRQGCKDLGALAVGISGSGPTMFAIAPDLEHAQKLVAYLEKDYLQNNEGFIHICKVDNQGAREL 314
Cdd:TIGR00191 230 ESLIPNLFKIKQAALEKGAYGITISGSGPTILAMADEEFAEQKEQDLLEVLHKQGIEGTVHVLDFDNDGARVE 302
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 1-315 1.79e-131

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 375.98  E-value: 1.79e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345   1 MTLRIYAPASSANLSVGFDSLGTAISpidgslLGDVVQIEDCDQP-FELESVGYFVRKLPKEPqKNIVYQAYVLFSERLk 79
Cdd:COG0083     1 KSVKVRVPATSANLGPGFDSLGLALS------LYDEVEVERSDEPgLEIEIEGEGADELPTDE-DNLVYQAALALLEKL- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345  80 lrGGVVKNLRLTLEKNMPIGSGLGSSACSIVAALVALNKFHDEPFSKMELLEMMGELEGrisgsiHYDNVAPCYLGGLQL 159
Cdd:COG0083    73 --GKEPPGLRIEIEKGIPLGRGLGSSAAAIVAGLVAANALLGLPLSKEELLELATEGEG------HPDNVAPALLGGLVL 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345 160 MTQSLGNI-CQPIPFFDEWYWVLAYPGIEVSTAEARAILPKSYTRQDMIAQARYLGSFIHACHTRQDVLAAIMMKDLIAE 238
Cdd:COG0083   145 SRSDGEPVrVVRLPVPPDLKAVVVIPDFELSTKEARAVLPKQVPLKDAVFNSSRAALLVAALATGDYELLGRAMEDRLHE 224

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1388888345 239 PYRESLLPNFAEVRQGCKDLGALAVGISGSGPTMFAIAPDlEHAQKLVAYLEKDYLQNNEGF-IHICKVDNQGARELK 315
Cdd:COG0083   225 PYRAKLIPGFDEVKEAALEAGALGAGISGAGPTVLALADD-EEAEAVAEAMKAAFAEAGIDArVYVLKIDNEGARVLE 301
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 89-156 7.18e-13

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 62.57  E-value: 7.18e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1388888345  89 RLTLEKNMPIGSGLGSSACSIVAALVALNKFHDepfskMELLEMMGELEGRIS-GSIHYDNVAPCYLGG 156
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFG-----LPLAKLALEAEELAGgGRGGGMDVAASLYGG 64
 
Name Accession Description Interval E-value
PRK01212 PRK01212
homoserine kinase; Provisional
 1-314 5.73e-158

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 443.05  E-value: 5.73e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345   1 MTLRIYAPASSANLSVGFDSLGTAISPIDGSLLGDVVQIEDcdqPFELESVGYFVRKLPKEPQKNIVYQAYVLFSERLkl 80
Cdd:PRK01212    2 MMVKVRVPATSANLGPGFDSLGLALSLYDEVLVGDVVSVEA---EFSIEVIGEGADKLPLDPEKNLVYQAALKFLEKL-- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345  81 rgGVVKNLRLTLEKNMPIGSGLGSSACSIVAALVALNKFHDEPFSKMELLEMMGELEGrisgsiHYDNVAPCYLGGLQLM 160
Cdd:PRK01212   77 --GKPPGLRIELEKNIPLGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLATEGEG------HPDNVAPALLGGLVLA 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345 161 TQSLGNICQPIPFFDEWYWVLAYPGIEVSTAEARAILPKSYTRQDMIAQARYLGSFIHACHTRQDVLAAIMMKDLIAEPY 240
Cdd:PRK01212  149 LEENGVISVKIPVFDDLKWVVAIPNIELSTAEARAVLPKQYSLKDAVFNSSRAALLVAALYTGDYELAGRAMKDVLHEPY 228

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1388888345 241 RESLLPNFAEVRQGCKDLGALAVGISGSGPTMFAIAPDlEHAQKLVAYLEKDYLQNNEGFIHICKVDNQGAREL 314
Cdd:PRK01212  229 RAKLIPGFAEVRQAALEAGALGAGISGAGPTVFALCDK-EDAEKVADALQKAFLQGIEGFVHVLRLDTAGARVL 301
thrB TIGR00191
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ...
 3-314 8.15e-149

homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 129295 [Multi-domain]  Cd Length: 302  Bit Score: 419.88  E-value: 8.15e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345   3 LRIYAPASSANLSVGFDSLGTAISPIDGSLLGDVVQIEDCDQpfELESVGYFVRKLPKEPQKNIVYQAYVLFSERLKLRG 82
Cdd:TIGR00191   1 FRVKVPASSANLGPGFDVLGAALSLYLGLTVTDVVAQESDDT--EIEAEGEGVEKIPTEPTDNLIYQVAKRFLDQLGIRM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345  83 GVVKnlrLTLEKNMPIGSGLGSSACSIVAALVALNKFHDEPFSKMELLEMMGELEGrisgsiHYDNVAPCYLGGLQLMTQ 162
Cdd:TIGR00191  79 PPVK---VTLEKNIPLGRGLGSSAAAIVAALAAANELCGLPLSKERLLDYASELEG------HPDNVAPALLGGFQLAFV 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345 163 SLG-NICQPIPFFDEWYWVLAYPGIEVSTAEARAILPKSYTRQDMIAQARYLGSFIHACHTRQDVLAAIMMKDLIAEPYR 241
Cdd:TIGR00191 150 EDDkLEVLKIPIFSKLDWVLAIPNIEVSTAEARAVLPKAYPRQDLVFNLSHLAGLVHAIYQKKPDLGAIMMKDRIHQPYR 229

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1388888345 242 ESLLPNFAEVRQGCKDLGALAVGISGSGPTMFAIAPDLEHAQKLVAYLEKDYLQNNEGFIHICKVDNQGAREL 314
Cdd:TIGR00191 230 ESLIPNLFKIKQAALEKGAYGITISGSGPTILAMADEEFAEQKEQDLLEVLHKQGIEGTVHVLDFDNDGARVE 302
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 1-315 1.79e-131

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 375.98  E-value: 1.79e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345   1 MTLRIYAPASSANLSVGFDSLGTAISpidgslLGDVVQIEDCDQP-FELESVGYFVRKLPKEPqKNIVYQAYVLFSERLk 79
Cdd:COG0083     1 KSVKVRVPATSANLGPGFDSLGLALS------LYDEVEVERSDEPgLEIEIEGEGADELPTDE-DNLVYQAALALLEKL- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345  80 lrGGVVKNLRLTLEKNMPIGSGLGSSACSIVAALVALNKFHDEPFSKMELLEMMGELEGrisgsiHYDNVAPCYLGGLQL 159
Cdd:COG0083    73 --GKEPPGLRIEIEKGIPLGRGLGSSAAAIVAGLVAANALLGLPLSKEELLELATEGEG------HPDNVAPALLGGLVL 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345 160 MTQSLGNI-CQPIPFFDEWYWVLAYPGIEVSTAEARAILPKSYTRQDMIAQARYLGSFIHACHTRQDVLAAIMMKDLIAE 238
Cdd:COG0083   145 SRSDGEPVrVVRLPVPPDLKAVVVIPDFELSTKEARAVLPKQVPLKDAVFNSSRAALLVAALATGDYELLGRAMEDRLHE 224

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1388888345 239 PYRESLLPNFAEVRQGCKDLGALAVGISGSGPTMFAIAPDlEHAQKLVAYLEKDYLQNNEGF-IHICKVDNQGARELK 315
Cdd:COG0083   225 PYRAKLIPGFDEVKEAALEAGALGAGISGAGPTVLALADD-EEAEAVAEAMKAAFAEAGIDArVYVLKIDNEGARVLE 301
PLN02451 PLN02451
homoserine kinase
 6-312 7.77e-43

homoserine kinase


Pssm-ID: 215248  Cd Length: 370  Bit Score: 151.10  E-value: 7.77e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345   6 YAPASSANLSVGFDSLGTAIspiDGslLGDVVQIE-DCDQP---FELESVGYFVRKLPKEPQKNIvyqAYVLFSERLKLR 81
Cdd:PLN02451   57 FAPATVANLGPGFDFLGCAV---DG--LGDFVTARvDPGVRpgeVSISEITGDTGRLSKDPLRNC---AGIAAIATMKLL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345  82 GGVVKNLRLTLEKNMPIGSGLGSSACSIVAALVALNKFHDEPFSKMELLEMMGELEGRISGsIHYDNVAPCYLGGLQLMT 161
Cdd:PLN02451  129 GIRSVGLSLSLHKGLPLGSGLGSSAASAAAAAVAVNELFGSPLGKDDLVLAGLESEAKVSG-YHADNIAPALMGGFVLIR 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345 162 --QSLGNICQPIPFFDEWYWVLAYPGIEVSTAEARAILPKSYTRQDMIAQARYLGSFIHAChTRQDV--LAAIMMKDLIA 237
Cdd:PLN02451  208 syEPLHLIPLRFPSAKDLFFVLVSPDFEAPTKKMRAALPKEIPMKHHVWNCSQAAALVAAI-LQGDAvlLGEALSSDKIV 286

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345 238 EPYRESLLPNFAEVRQGCKDLGALAVGISGSGPTMFAIAPDLEH----AQKLV-AYLEKDYLQNNEgfiHICKVDNQGAR 312
Cdd:PLN02451  287 EPTRAPLIPGMEAVKKAALEAGAYGCTISGAGPTAVAVIDDEEKgeevGERMVeAFRKAGNLKATA---SVKKLDRVGAR 363
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 27-293 5.98e-38

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 136.02  E-value: 5.98e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345  27 PIDgslLGDVVQIEDCDQP-FELESVGYFVrklpKEPQKNIVYQAYVLFSERLKLRGGVvknlRLTLEKNMPIGSGL--G 103
Cdd:COG1947    33 FID---LGDTLTIEPADDGsISLTGPGAGV----PTDEDNLVYRAARLLQEATGIPPGV----DIHLEKRIPVGAGLggG 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345 104 SS--AcsivAALVALNKFHDEPFSKMELLEMMGELegrisGSihyDnVAPCYLGGLQLMTqSLGNICQPIPFFDEWYWVL 181
Cdd:COG1947   102 SSdaA----ATLRALNRLWGLGLSREELAELAAKL-----GA---D-VPFFLYGGTALAE-GRGEKLTPLPPLPELWLVL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345 182 AYPGIEVSTAEA-RAILPKSYTrqdmiaQARYLGSFIHACHTRQDVLAAIMMKDLiaEPYRESLLPNFAEVRQGCKDLGA 260
Cdd:COG1947   168 VKPGVGVSTAEVyRALDLTRDT------PPPDIDALLAALAAGDAALAALLRNDL--EPVAFKLYPEIAEVLEALLEAGA 239

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1388888345 261 LAVGISGSGPTMFAIAPDLEHAQKLVAYLEKDY 293
Cdd:COG1947   240 LAARMSGSGSTVFGLFEDEEAAEAAAAALPARG 272
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 1-287 2.74e-16

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 77.55  E-value: 2.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345   1 MTLRIYAPASsANLSV--------GFDSLGTAISPIDgslLGDVVQIE--DCDQPFELESVgyfvRKLPKEpqKNIVYQA 70
Cdd:TIGR00154   1 MRHVFPAPAK-INLFLyilgkrpdGYHELQMLMQFID---LGDKIIISvrSDDDIRLLKGD----FDVPLE--ENLAYRA 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345  71 YVLFSERLKLRGGVVKNLRLTLEKNMPIGSGLGSSACSIVAALVALNKFHDEPFSKMELLEMMGELegrisGSihydNVA 150
Cdd:TIGR00154  71 AQLLKNFANSKIKSLDGVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATL-----GA----DVP 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345 151 PCYLGGLQLMTqSLGNICQPIPFFDEWYWVLAYPGIEVSTAEA-RA-----ILPKSYTRQDMIAQARYLGSFihACHTRQ 224
Cdd:TIGR00154 142 FFVSGGTAFAT-GRGEIITPFEDPPEKWVVIAKPHVSVSTPVVyQAyklprNTPKRAKEWLKKISLECLQLL--DSNGLN 218

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1388888345 225 DVLAAIMmkdliaepyreSLLPNFAEVRQGCKDLGALAVGISGSGPTMFAIAPDLEHAQKLVA 287
Cdd:TIGR00154 219 DLEKVAL-----------KRHTEVAQALNWLLEYGLAPERMSGSGPCVFALFDMESEAEQVLE 270
bRFAP COG1907
Beta-ribofuranosylaminobenzene 5'-phosphate synthase (methanopterin biosynthesis) [Coenzyme ...
 74-312 1.87e-15

Beta-ribofuranosylaminobenzene 5'-phosphate synthase (methanopterin biosynthesis) [Coenzyme transport and metabolism];


Pssm-ID: 441511  Cd Length: 316  Bit Score: 75.63  E-value: 1.87e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345  74 FSERLKLRGGVvknlRLTLEKNMPIGSGLGSSACSIVAALVALNKFHDEPFSKMELLEMMGEleGRISGsIhydNVAPCY 153
Cdd:COG1907    66 LLEALGVPGGV----RITVEEAIPRHVGLGSGTQLALAVAAALARLYGLPLSVRELARLLGR--GGRSG-I---GVAAFE 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345 154 LGGLQLMTQSLGNICQP-----IPFFDEWYWVLAYP--GIEVSTAEARAILpKSYTRQDmIAQARYLgsfihaCH--TRQ 224
Cdd:COG1907   136 RGGFIVDGGHPTERTVPpliarHDFPEDWRFLLVIPdaGRGLHGEEEVDAF-RRLPPLP-PEDADEL------CRlvLMQ 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345 225 dVLAAIMMKDL------IAEpYRESLLPNFAEVRQGC-------------KDLGALAVGISGSGPTMFAIAPDLEHAQKL 285
Cdd:COG1907   208 -LLPALAEGDLeafgeaINE-IQRLGGDYFAPAQGGVyrspaveevlellREAGAEGVGQSSWGPTVYGITDSEEEAEAI 285

                         250       260
                  ....*....|....*....|....*..
gi 1388888345 286 VAYLEKDYLQNNEGFIHICKVDNQGAR 312
Cdd:COG1907   286 AAALRALLDRGVGGEVIVTRARNRGAE 312
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 17-289 1.82e-14

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 72.62  E-value: 1.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345  17 GFDSLGT---AISpidgslLGDVVQIEDCDQPfELESVGYFVRKLPKEPqKNIVYQAYVLFSERLKLRGGVvknlRLTLE 93
Cdd:PRK03188   22 GYHELATvfqAVS------LYDEVTVTAADVL-SVEVSGEGADQVPTDE-SNLAWRAAELLAEHVGRAPDV----HLHID 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345  94 KNMPIGSGL-GSSAcSIVAALVALNKFHDEPFSKMELLEMMGELegrisGSihydNVAPCYLGGLQLMTqSLGNICQPIP 172
Cdd:PRK03188   90 KGIPVAGGMaGGSA-DAAAALVACDALWGLGLSRDELLELAAEL-----GS----DVPFALLGGTALGT-GRGEQLAPVL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345 173 FFDEWYWVLAYPGIEVSTaearailPKSYTRQDMIAQARYLGS------FIHACHTRQ-DVLAAIMMKDLiaEPYRESLL 245
Cdd:PRK03188  159 ARGTFHWVLAFADGGLST-------PAVFRELDRLREAGDPPRlgepdpLLAALRAGDpAQLAPLLGNDL--QAAALSLR 229

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1388888345 246 PNFAEVRQGCKDLGALAVGISGSGPTMFAIAPDLEHAQKLVAYL 289
Cdd:PRK03188  230 PSLRRTLRAGEEAGALAGIVSGSGPTCAFLCADADSAVDVAAAL 273
PRK14611 PRK14611
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
52-275 4.00e-14

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 184767 [Multi-domain]  Cd Length: 275  Bit Score: 71.32  E-value: 4.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345  52 GYFVRKLPKEPQ----KNIVYQAYVLFSERLklrgGVVKNLRLTLEKNMPIGSGLGSSACSIVAALVALNKFHDEPFSKM 127
Cdd:PRK14611   45 HHTLEVKTSSPQikeeENIVYKALRLFERYT----GIDINYSIFIEKNIPVGAGLGGGSSNAAVVLKYLNELLGNPLSEE 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345 128 ELLEmmgelegrISGSIHYDnvAPCYLGGLQLMTQSLGNICQPIPFFDEWYWVLAYPGIEVSTAEA-RAILPKSYTRQ-- 204
Cdd:PRK14611  121 ELFE--------LASSISAD--APFFLKGGFALGRGIGDKLEFLEKPISREITLVYPNIKSSTGRVySKVTKQILTNKed 190

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1388888345 205 -DMIAQARYLGSFIHACHTRQDVLAAIMMKdliaepyresLLPNFAEVRQGCKDLGALAVgISGSGPTMFAI 275
Cdd:PRK14611  191 lNIIISLLREGEEKKIEEVIENTLGEIALE----------LYPEIKEVYRFLEYLGYKPF-VSGSGSSVYVF 251
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 37-193 1.45e-13

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 69.49  E-value: 1.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345  37 VQIEDCDQ-PFELESVGY---FVRKLPKEPQKNIVYQAYVLFSERLKLRggvVKNLRLTLEKNMPIGSGLGSSACSIVAA 112
Cdd:COG1577    30 VTVEPSDDdKLRIESPDLggtLDLDPLADAALRYIKAAIEAALEYLGLP---LKGFDIEIDSEIPRKRGLGSSAAVAVAV 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345 113 LVALNKFHDEPFSKMELLE--MMGELE--GRISGsihYDNVApCYLGGLQLMTQslGNICQPIPFFDEWYWVLAYPGIEV 188
Cdd:COG1577   107 IRALAAFYGVELSKEELFKlaLEAEKIvhGNPSG---LDTAA-STYGGPIYYQR--GDRAEPLELPKNLPLVVGDTGVPA 180


                  ....*
gi 1388888345 189 STAEA 193
Cdd:COG1577   181 STKEL 185
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 89-156 7.18e-13

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 62.57  E-value: 7.18e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1388888345  89 RLTLEKNMPIGSGLGSSACSIVAALVALNKFHDepfskMELLEMMGELEGRIS-GSIHYDNVAPCYLGG 156
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFG-----LPLAKLALEAEELAGgGRGGGMDVAASLYGG 64
PRK14608 PRK14608
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 34-292 1.13e-10

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 237765 [Multi-domain]  Cd Length: 290  Bit Score: 61.02  E-value: 1.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345  34 GDVVQIEDCDQPfELESVGYFVRKLPKEPQkNIVYQAYVLFSERLklrGGVVKNLRLTLEKNMPIGSGLGSSACSIVAAL 113
Cdd:PRK14608   42 GDRLTLEPAEAL-SLTVSGPFAAGLGDGDD-NLVLRAARALRARV---GPGLPPGAFHLEKNLPVAAGIGGGSADAAAAL 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345 114 VALNKFHDEPFSKMELLEMMGELegrisGSihydNVAPCyLGGLQLMTQSLGNICQPIPFFDEWYWVLAYPGIEVSTAEA 193
Cdd:PRK14608  117 RLLARLWGLALDDERLAALALSL-----GA----DVPVC-LDSRPLIMRGIGEELTPLPGLPSLPAVLVNPGVPVATPDV 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345 194 -RAilpksYTRQDmiAQARYLGSfiHACHTRQDVLAAI--MMKDLiaEPYRESLLPNFAEVRQGCKDL-GALAVGISGSG 269
Cdd:PRK14608  187 fRA-----LGLRD--GPPLPGAP--DPLASADALLAALaaTRNDL--EPPALALAPVIGEVLAALRAQpGALLARMSGSG 255

                         250       260
                  ....*....|....*....|...
gi 1388888345 270 PTMFAIAPDLEHAQKLVAYLEKD 292
Cdd:PRK14608  256 ATCFALFADEAAAEAAAAAIAAA 278
PTZ00299 PTZ00299
homoserine kinase; Provisional
 8-277 2.39e-10

homoserine kinase; Provisional


Pssm-ID: 140320  Cd Length: 336  Bit Score: 60.67  E-value: 2.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345   8 PASSANLSVGFDSLGTAISpidgslLGDVVQIEDCDQpFELESVGYFVRKLPKEPQKNIVYQAYVLFSERLKLRggvVKN 87
Cdd:PTZ00299   13 PATTANIGPAYDTLGMALS------IFMELTVEHADA-FSMTVEGEGSEHISTDEDNMVVQACRLAFEEYAHKS---MPP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345  88 LRLTLEKNMPIGSGLGSSACSIVAALVA---LNKFHDEPFSKMELLEMMGELEGrisgsiHYDNVAPCYLGGLQLMTQSL 164
Cdd:PTZ00299   83 LKFIMHSNIPYGCGCGSSSAAAVAGFVAgmkLCGLTMETENEEALLQAIAKFEG------HPDNAAPAIYGGIQLVYKKD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345 165 GNICQ----PIPFFDEWYWVLAYPGIEVSTAEARAILPKSYTRQDMIAQARYLGSFIHACHTrQDVLAAIMMKDLIAEPY 240
Cdd:PTZ00299  157 NGRFLtyrvPTPPNLSVVLFVPHNKMKANTHVTRNLIPTSVSLEDAVFNISRTSILVLALST-GDLRMLKSCSDKLHEQQ 235

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1388888345 241 R-ESLLPNFAEVRQGCKDLGALAVGISGSGPTMFAIAP 277
Cdd:PTZ00299  236 RsDALFPHFRPCVKAAREAGAHYAFLSGAGPSVCALVG 273
PduX COG4542
PduX protein involved in propanediol utilization and related proteins [Secondary metabolites ...
 86-312 1.90e-09

PduX protein involved in propanediol utilization and related proteins [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443608 [Multi-domain]  Cd Length: 286  Bit Score: 57.56  E-value: 1.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345  86 KNLRLTLEKNMPIGSGLGSSACSIVAALVALNKFHDEPFSKMELLEMMGELEGriSGSIHYDnvapcylgGLQLMTQSLG 165
Cdd:COG4542    69 LGGRIELRSDIPVGKGMASSTADIAATARAVARALGKELSPEELARLAVAIEP--TDSTMFP--------GLVLFDHREG 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345 166 NICQPIPFFDEWYWVLAYPGIEVSTAEARAILPKSYTRQD--MIAQARYLgsFIHAChTRQDV--LAAIMMKDLIAEpyr 241
Cdd:COG4542   139 RVLEPLGPLPPLDILGLDSGGTVDTLAFNRRDLAELNRAEepEIERALAL--LREAL-RTGDLalLGEAATLSARAN--- 212

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1388888345 242 ESLL--PNFAEVRQGCKDLGALAVGISGSGpTMFAI--APDLEHAQKLVAYLEKDYLQNNEGFIHICKVDNQGAR 312
Cdd:COG4542   213 QRILpkPELEELLALAEELGALGVNVAHSG-TVLGLlfDPGDHDVEKLAEALRRRLLRLGYPRIGLVRIINGGIR 286
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 23-193 9.35e-08

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 52.29  E-value: 9.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345  23 TAI-SPIDgsLLGDVVQIEDCDQPFELESVGY-FVRKLPKEPQKNI-VYQAYVLFSERLKLrggvvKNLRLTLEKNMPIG 99
Cdd:TIGR00549  18 PAIaAPIP--LRTTVTVIESSDGSFIESDLGRgSLDDAPDELDGLKyVLAEFLSRFSELNP-----PPLEITIESEIPPG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345 100 SGLGSSACSIVAALVALNKFHDEPFSKMELLEMMGELE----GRISGsihYDNvAPCYLGGLQLMTQSLGNICQPIPFFD 175
Cdd:TIGR00549  91 RGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEkiahGKPSG---IDT-ATSTSGGPVYFEKGEGEFTKLISLDG 166

                         170
                  ....*....|....*...
gi 1388888345 176 ewYWVLAYPGIEVSTAEA 193
Cdd:TIGR00549 167 --YFVIADTGVSGSTKEA 182
PRK03926 PRK03926
mevalonate kinase; Provisional
 37-203 2.25e-06

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 48.51  E-value: 2.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345  37 VQIEDCDQPFELESVgyfvrkLPKEPQKN-IVYQAYVLFSERLKLRGgvvknLRLTLEKNMPIGSGLGSSACSIVAALVA 115
Cdd:PRK03926   35 VRAEFNDDSIYIESD------YGKTGEKHpYVSAAIEKMREEADKDG-----VTVSITSQIPVGSGLGSSAAVTVATIGA 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345 116 LNKFHDEPFSKMELLEMMGELEGRISGSIHYDNVAPCYLGGLQL--MTQSLGNICQPIpffdewywVLAYPGIEVSTAEA 193
Cdd:PRK03926  104 LNRLLGLGLSLEEIAKLGHKVELLVQGAASPTDTYVSTMGGFVTipDRKKLPFPECGI--------VVGYTGSSGSTKEL 175

                         170
                  ....*....|
gi 1388888345 194 RAILPKSYTR 203
Cdd:PRK03926  176 VANVRKLKEE 185
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 227-293 4.46e-06

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 44.00  E-value: 4.46e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1388888345 227 LAAIMMKDLIAEPYRESLLPNFAEVRQGCKDLGaLAVGISGS--GPTMFAIAPDLEHAQKLVAYLEKDY 293
Cdd:pfam08544  16 LLTESAESLEPLLVVGILPPELDELLEALLELG-LGAKLSGSggGPTVFALFKDEDDAEEVARALREAG 83
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
78-129 4.18e-05

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 44.76  E-value: 4.18e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1388888345  78 LKLRGGVVKNLRLTLEKNMPIGSGLGSSACSIVAALVALNKFHDEPFSKMEL 129
Cdd:COG0153    99 LQERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVEL 150
PRK04181 PRK04181
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 31-132 5.75e-05

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235243  Cd Length: 257  Bit Score: 43.80  E-value: 5.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345  31 SLLGDVVQIEDCDQPFELESvgyfvrKLPKEPQKNIVYQAYVL-----FSERLKlrgGVVKNLRLTLEKNMPIGSGLGSS 105
Cdd:PRK04181   34 DLFDEIEFVPKSAESFELIG------NFDCPLEENIIYKAYQElknkgFSNELI---EFFKKKAIEVEKNIPTGAGLGGG 104

                          90       100
                  ....*....|....*....|....*..
gi 1388888345 106 ACSIVAALVALNKFHDEPFSKMELLEM 132
Cdd:PRK04181  105 SSDAATFLLMLNEILNLKLSLEELAEI 131
PRK03817 PRK03817
galactokinase; Provisional
 78-137 9.74e-05

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 43.45  E-value: 9.74e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388888345  78 LKLRGGVVKNLRLTLEKNMPIGSGLGSSACSIVAALVALNKFHDEPFSKMELLEMMGELE 137
Cdd:PRK03817   77 LEKRGYEVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAE 136
COG2605 COG2605
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ...
 83-137 5.34e-04

Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];


Pssm-ID: 442017 [Multi-domain]  Cd Length: 328  Bit Score: 41.32  E-value: 5.34e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1388888345  83 GVVKNLRLTLEKNMPIGSGLGSSACSIVAALVALNKFHDEPFSKMELLEMMGELE 137
Cdd:COG2605    82 GIGDGLEITTDSDAPAGSGLGSSSALTVALLNALHALLGLPLSPYDLARLAYEIE 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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