|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
12-462 |
9.38e-71 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 228.98 E-value: 9.38e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 12 IGIFIFMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLAGi 91
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCA- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 92 nLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWINVP 171
Cdd:cd17321 80 -LAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 172 VGIIAYFLGshalpkekakgsvqevdfigsalmaltivflflginygqiagwsnpfvigaiilavilfvlfirtenrksv 251
Cdd:cd17321 159 IGLVALLLA----------------------------------------------------------------------- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 252 plidlgifksKLFSLSVLTAMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDKELIT 331
Cdd:cd17321 168 ----------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVL 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 332 FIGISGIIIAQLGYLSISGNTPYGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIAFVLGTSLAT 411
Cdd:cd17321 238 VAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLG 317
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 1391035794 412 ISLFFAMSS-LAGRHITTYIASQPKLFLDGMHISLFVSLVLVIITWILSLMR 462
Cdd:cd17321 318 ALLTAGLSAnLGDSGVAALLSAAAAAFAAGFHLAFLVAAALALLAALLALLL 369
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
6-411 |
8.50e-66 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 219.56 E-value: 8.50e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 6 ILALISIGIFIFMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIG 85
Cdd:TIGR00711 1 LLLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 86 SFLAGI--NLGWglpfLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWN 163
Cdd:TIGR00711 81 SLLCGVapNLEL----MIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 164 YIFWINVPVGIIAYFLGSHALPKEKAKGSvQEVDFIGSALMALTIVFLFLGINYGQIAGWSNP-FVIGAIILAVILFVLF 242
Cdd:TIGR00711 157 WIFLINVPIGIIVVVVAFFILPRDKPAAS-ENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSnEILILSITGLVAIIAF 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 243 IRTENRKSVPLIDLGIFKSKLFSLSVLTAMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLS 322
Cdd:TIGR00711 236 VVWELTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 323 DKYDKELITFIGISGIIIAQLGYL-SISGNTPYGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNI 401
Cdd:TIGR00711 316 DKIDPRKLVTIGLILYAVGFYWRAfTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQL 395
|
410
....*....|
gi 1391035794 402 AFVLGTSLAT 411
Cdd:TIGR00711 396 GGSIGTALIT 405
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
12-460 |
4.07e-57 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 193.56 E-value: 4.07e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 12 IGIFIFMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLAGi 91
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCG- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 92 nLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWINVP 171
Cdd:cd17503 80 -LAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 172 VGIIAYFLGshalpkekakgsvqevdfigsalmaltivflflginygqiagwsnpfvigaiilavilfvlfirtenrksv 251
Cdd:cd17503 159 IGILALLLA----------------------------------------------------------------------- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 252 PLIDLGIFKSKLFSLSVLTAMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDKELIT 331
Cdd:cd17503 168 PLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLL 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 332 FIGISGIIIAQLGYLSISGNTPYGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIAFVLGTSLAT 411
Cdd:cd17503 248 LAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLA 327
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 1391035794 412 ISL-FFAMSSLAGRHITTYIASQPKLFLDGMHISLFVSLVLVIITWILSL 460
Cdd:cd17503 328 TLLtNRTQFHHSRLSELLAQQVQKQALIIAFNDAFLVSAILLLVGLLLAL 377
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
3-402 |
1.06e-39 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 146.27 E-value: 1.06e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 3 KNRILALISIGIFIFMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIF 82
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 83 TIGSFLAGinLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSW 162
Cdd:COG2814 86 ALGSLLCA--LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 163 NYIFWINVPVGIIAYFLGSHALPKEKAkgsvqevdfigsalmaltivflflginygqiagwsnpfvigaiilavilfvlf 242
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRLLPESRP----------------------------------------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 243 irtENRKSVPLIDLGIFKSKLFSLSVLTAMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLS 322
Cdd:COG2814 191 ---AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLA 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 323 DKYDKELITFIGISGIIiaqLGYLSISGNTPYGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIA 402
Cdd:COG2814 268 DRFGRRRLLLIGLLLLA---LGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
16-423 |
2.00e-38 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 142.70 E-value: 2.00e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 16 IFMSTLDGSIVNVALPTMSRELQvSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLAGinLGW 95
Cdd:cd17502 5 LFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCG--LAP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 96 GLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWINVPVGII 175
Cdd:cd17502 82 NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 176 AYFlgshalpkekakgsvqevdFIGSALMALTIVFLFLGINYGQIagwsnpfvigaiilavilfvlfirtenrksvplid 255
Cdd:cd17502 162 ALA-------------------LLRTILLSSIFGFLFGGALFGLI----------------------------------- 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 256 lgifksklfslsvltamlnftaamfvnILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLSDK--YDKELITFI 333
Cdd:cd17502 188 ---------------------------YYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKtgRYKPLIVIG 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 334 GISGIIIAQLGYLsISGNTPYGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIAFVLGTSLATIs 413
Cdd:cd17502 241 TILMSVGAGLLTT-LTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAITDV- 318
|
410
....*....|
gi 1391035794 414 lFFAMSSLAG 423
Cdd:cd17502 319 -FLVALALAA 327
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
16-461 |
6.99e-33 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 128.08 E-value: 6.99e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 16 IFMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLAGinLGW 95
Cdd:cd17504 5 ALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAA--FAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 96 GLPFLLFARIVQAVGGSMFmATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWINVPVGII 175
Cdd:cd17504 83 NLPVLIAGRALQGIGGAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 176 AYFLgshalpkekakgsvqevdfigsalmaltivflflginygqiagwsnpfvigaiilavilfvlfirtenrksVPLID 255
Cdd:cd17504 162 LAAL-----------------------------------------------------------------------VPLID 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 256 LGIFKSKLFSLSVLTAMLNFTAAMFVNILMPFFLQD----YHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDKELIT 331
Cdd:cd17504 171 LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVL 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 332 FIGISGIIIAQLGYLSISGNTpyGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIafvlGTSLAT 411
Cdd:cd17504 251 LIGLVISAVGLLLLALLHSSL--WALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTI----GSAIGP 324
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 1391035794 412 ISLFFAMSSLAGRHITTYIASqpklfLDGMHISLFVSLVLVIITWILSLM 461
Cdd:cd17504 325 AIAGAILTTYTVSITSGGVPT-----EGAYVLAFLIGAALALAALLLSLL 369
|
|
| MFS_efflux_LmrB |
NF000060 |
lincomycin efflux MFS transporter Lmr(B); The lin-2 mutant, described in PMID:12499232, alters ... |
9-410 |
2.26e-31 |
|
lincomycin efflux MFS transporter Lmr(B); The lin-2 mutant, described in PMID:12499232, alters Lmr(B) expression in Bacillus subtilis and allows Lmr(B) to confer resistance to lincomycin.
Pssm-ID: 411077 [Multi-domain] Cd Length: 479 Bit Score: 125.91 E-value: 2.26e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 9 LISIGIFIFMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFL 88
Cdd:NF000060 19 MISLLLAGFIGMFSETALNIALTDLMKELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFI 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 89 AGinLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWI 168
Cdd:NF000060 99 AA--LAPSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTFSGLVLEHLNWHWIFWI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 169 NVPVGIIAYFLGSHALPK--EKAKGSVQEVDFIGSALMALTIVFLFLGINYGQiAGWSNPFVIGAIILAVILFVLFIRTE 246
Cdd:NF000060 177 SLPFLVLALVFGIAYMQNvsETTKPKIDVLSIILSTIGFGGIVFGFSNAGEGS-GGWSSPTVIVSLIVGVVGLILFSIRQ 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 247 NRKSVPLIDLGIFKSKLFSLSVLTAMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYD 326
Cdd:NF000060 256 LTMKQPMMNLRAFKYPMFILGVIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKYG 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 327 KELITFIGISGIIIAQLGYLSISGNTPYGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIAFVLG 406
Cdd:NF000060 336 PKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQLPREFYPDGTAIMNTLQQMAGAIG 415
|
....
gi 1391035794 407 TSLA 410
Cdd:NF000060 416 TAVA 419
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
3-289 |
1.31e-29 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 117.22 E-value: 1.31e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 3 KNRILALISIGIFIFMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIF 82
Cdd:COG0477 10 RRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 83 TIGSFLAGINlgWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSW 162
Cdd:COG0477 90 GLASLLCGLA--PSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGW 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 163 NYIFWINVPVGIIAYFLGSHALPKEKAKGSVQEVDFIGSALMALTIVFLFLGINYGQIAGWSNPFVIGAIILAVILFVLF 242
Cdd:COG0477 168 RWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLL 247
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1391035794 243 IRTENRKSVPLIDLGIFKSKLFSLSVLTAMLNFTAAMFVNILMPFFL 289
Cdd:COG0477 248 LALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
17-304 |
1.44e-29 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 120.61 E-value: 1.44e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 17 FMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLAGinLGWG 96
Cdd:PRK10504 20 FMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCA--LSGT 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 97 LPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWINVPVGIIA 176
Cdd:PRK10504 98 LNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIG 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 177 YFLGSHALPKEKAkgSVQEVDFIGSALMALTIVFLFLGINYGQIAGWSNPFVIGAIILAVILFVLFIRTENRKSVPLIDL 256
Cdd:PRK10504 178 AIATLMLMPNYTM--QTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNNRALFSL 255
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1391035794 257 GIFKSKLFSLSVLTAMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMM 304
Cdd:PRK10504 256 KLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMM 303
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
7-420 |
1.43e-28 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 117.91 E-value: 1.43e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 7 LALISIGIFIFMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGS 86
Cdd:PRK14995 6 LTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLAS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 87 FLAGINLGWGLpfLLFARIVQAVGGSMFM-ATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYI 165
Cdd:PRK14995 86 LAAAFSPTASW--LIATRALLAIGAAMIVpATLAGIRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 166 FWINVPVGIIAYFLGSHALPKEKAKGSvQEVDFIGSALMALTIVFLFLGINYGQIAGWSNPFVIGAIILAVILFVLFIRT 245
Cdd:PRK14995 164 FLINVPIVLVVMGLTARYVPRQAGRRD-QPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 246 ENRKSVPLIDLGIFKSKLFSLSVLTAMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKY 325
Cdd:PRK14995 243 QLAASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 326 DKELITFIGISGIIIAQLGYLSISGNTPYGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIAFVL 405
Cdd:PRK14995 323 GLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGL 402
|
410
....*....|....*
gi 1391035794 406 GTSLATISLFFAMSS 420
Cdd:PRK14995 403 GIAIFGLLLSRSYSA 417
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
10-411 |
1.35e-27 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 115.42 E-value: 1.35e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 10 ISIGIFIFMSTLDGSIVNVALPTMSRELQVSlAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLA 89
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPS-SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 90 GI--NLGWglpfLLFARIVQAVGGSMFMAtSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQ--ITSWNYI 165
Cdd:cd06179 80 GTakSVNM----LIGGQALIGIGAGTQGL-GAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEanAAGWRWI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 166 FWINVPVGIIA-------YFLGSHALPKEKAKGS-VQEVDFIGSALMALTIVFLFLGINYG-QIAGWSNPFVIGAIILAV 236
Cdd:cd06179 155 FYINAIFNALAlillfffYHPPPRPQLHGSSTRQkLKRLDWVGLFLLIAGLVLFLLGLSWGgNPYPWSSAHVIAPLVIGG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 237 ILFVLFIRTE--NRKSVPLIDLGIFKSKLFSLSVLTAMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLIS 314
Cdd:cd06179 235 VLLIAFGLYEwkGTKDGLLPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFG 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 315 SPISGVLSDKYDKELITFIGISGIIIAQLGYLSISGNTPYGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSV 394
Cdd:cd06179 315 AILAGLLLTKIKHIKWQLVAGFVLFTAFLALLALITPDNKALAIAFSVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGL 394
|
410
....*....|....*..
gi 1391035794 395 NSLARNIAFVLGTSLAT 411
Cdd:cd06179 395 LGSARALGGAVGTAIFT 411
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
16-412 |
3.62e-25 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 106.51 E-value: 3.62e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 16 IFMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLAGINLGW 95
Cdd:cd17325 5 LFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 96 glPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWINVPVGII 175
Cdd:cd17325 85 --WQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 176 AYFLGSHALPKEKAKGSVQEVDfigsalmaltivflflginygqiagwsnpfvigaiilavilfvlfirtenRKSVPLID 255
Cdd:cd17325 163 ALVLALLLLPEPRPPPNKRAVS--------------------------------------------------AARLRSGL 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 256 LGIFKSKLFSLSVLTAMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDKELITFIgi 335
Cdd:cd17325 193 RLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILI-- 270
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1391035794 336 sGIIIAQLGYLSISGNTPYGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIAFVLGTSLATI 412
Cdd:cd17325 271 -GLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGF 346
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
17-406 |
7.87e-24 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 102.65 E-value: 7.87e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 17 FMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLAGinLGWG 96
Cdd:cd17474 9 LLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCG--LSDS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 97 LPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQItSWNYIFWInvpvgiia 176
Cdd:cd17474 87 FALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFL-------- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 177 yflgshalpkekakgsvqevdfigsalmaltivflflginygqiagwsnpfvIGAIILAVILFVLFIRTENRKSVPLIDL 256
Cdd:cd17474 158 ----------------------------------------------------LAALIPVAFLAILFLLPEPKEKAKSSSA 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 257 GIFKSKLFSLSVLTAMLNFTAAMFVNIL-------MPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISG-VLSDKYDKE 328
Cdd:cd17474 186 TKLRDLKKALRGRGLLTFLVSAFLYFFLyfafltyLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGAR 265
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1391035794 329 LITFIGISGIIIAQLGYLSISGntpYGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIAFVLG 406
Cdd:cd17474 266 RILVIGLLLYALSLLLLGFVPS---LALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG 340
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
12-407 |
8.71e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 102.11 E-value: 8.71e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 12 IGIFIFMSTLDGSIVNVALP-TMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLAG 90
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 91 inLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWINV 170
Cdd:pfam07690 81 --FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 171 PVGIIAyflgshalpkekakgsvqevdfigsalmaltIVFLFLGINYGQIAGwsnpfvigaiilavilfvlFIRTENRKS 250
Cdd:pfam07690 159 ILSLLA-------------------------------AVLLLLPRPPPESKR-------------------PKPAEEARL 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 251 VPLIDLGIFKSKLFSLSVLTAMLNFTAAMFVNILMPFFLQDYhGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDKELI 330
Cdd:pfam07690 189 SLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL-GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRR 267
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1391035794 331 TFIGISGIIIAQLGYLSISGNTPYGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIAFVLGT 407
Cdd:pfam07690 268 LLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
30-410 |
1.68e-22 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 98.78 E-value: 1.68e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 30 LPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLAGinLGWGLPFLLFARIVQAV 109
Cdd:cd17324 22 LPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA--LAPSFALLLLARALAGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 110 GGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWINVPVGIIAYFLGSHALPKEKA 189
Cdd:cd17324 100 AHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 190 KGSVQevdfigsalmaltivflfLGINYGQIAGWSNPfvigaiilavilfvlfirtenrksvplidlgifksKLFSLSVL 269
Cdd:cd17324 180 KKPGS------------------LGLLSSLLLLLRNP-----------------------------------RLRLAYLI 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 270 TAMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTAYpVAMLISSPISGVLSDKYdkeLITFIGISGIIIAQLGYLSIS 349
Cdd:cd17324 207 TFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFG-VAGVVGSPLAGRLADRG---GRRALLIALLLLAAALLLLTL 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1391035794 350 GNTPYGFVIAALALHGLSVGFFQSPNNALVMStVDKKYLGIAGSVNSLARNIAFVLGTSLA 410
Cdd:cd17324 283 LGPSPLLLLVGLVLWGLGFFAAHSALQTRVLR-LAPEARGLASSLYLAAYNLGGALGAALG 342
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-410 |
5.89e-22 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 96.86 E-value: 5.89e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 3 KNRILALISIGIFIFMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIF 82
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 83 TIGSFLAGinLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSW 162
Cdd:COG2271 86 GLATLLFG--FATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 163 NYIFWInvpvgiiayflgshalpkekakgsvqevdfigsalmaltivflflginygqiagwsnpFVIGAIILAVILFVLF 242
Cdd:COG2271 164 RAAFLI----------------------------------------------------------LGLPGLLLALLRFWLL 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 243 IrtenrksvplidlgifksklfslsvLTAMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLS 322
Cdd:COG2271 186 A-------------------------LAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLS 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 323 DKYDKELITFIGISGIIIAqLGYLSISGNTPYGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIA 402
Cdd:COG2271 241 DRLGRRRKLVLAIGLLLAA-LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLG 319
|
....*...
gi 1391035794 403 FVLGTSLA 410
Cdd:COG2271 320 GALGPLLV 327
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
6-410 |
3.98e-21 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 94.56 E-value: 3.98e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 6 ILALISIGIFIFMSTldgSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIG 85
Cdd:cd17320 1 LLLLALLVALGPLAI---DMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 86 SFLAGinLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYI 165
Cdd:cd17320 78 SLLCA--LASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 166 FWINVPVGIIAYFLGSHALPKEKAKGSvqevdfigsalmaltivflflginygqiagwsnpfvigaiilavilfvlfiRT 245
Cdd:cd17320 156 FVFLALLGLLLLLLVLLFLPETLPEEK---------------------------------------------------RK 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 246 ENRKSVPLIDLGIFKSKLFSLSVLTAMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKY 325
Cdd:cd17320 185 PLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRF 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 326 DKELITFIGISGIIIA---QLGYLSISGNTPYGFViAALALHGLSVGfFQSPNNALVMSTVDKKYLGIAGSVNSLARNIA 402
Cdd:cd17320 265 GPRRLLRLGLLLLLAAalvLLLAALLGGLSLWPLV-APLFLIFFGFG-LIFPNATSLALEPFPHVAGTASALLGFLQFLI 342
|
....*...
gi 1391035794 403 FVLGTSLA 410
Cdd:cd17320 343 GALAGALV 350
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
3-414 |
3.70e-19 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 89.17 E-value: 3.70e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 3 KNRILALISIGIFIFMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIF 82
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 83 TIGSFLAGINLGWGLpfLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSW 162
Cdd:COG2223 81 GIGLLLLALAVSYWL--LLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 163 NYIFWInvpvgiiayflgshalpkekakgsvqevdfIGSALMALTIVFLFLGINYGQIAGWSNPFVIGAIilavilfvlf 242
Cdd:COG2223 159 RNAFLI------------------------------LGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQ---------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 243 irtenrksvplidLGIFKSKLFSLSVLTAMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLS 322
Cdd:COG2223 199 -------------LEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLS 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 323 DKYDKELITFIGISGIIIAqLGYLSISGNTPYGFVIAALALhGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIA 402
Cdd:COG2223 266 DRIGGRRVLLIVFALMALG-LLLLALALGSLWLFLVLFLLL-GLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLG 343
|
410
....*....|..
gi 1391035794 403 FVLGTSLATISL 414
Cdd:COG2223 344 GFLGPLLFGALL 355
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
7-398 |
9.95e-18 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 84.55 E-value: 9.95e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 7 LALISIGIFIFMStldGSIVNVALPTMSRELQ-VSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIG 85
Cdd:cd17473 2 ITLLLASTLTVMA---GAAIAPALPAIAQHFVpNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 86 SFLAGinLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQItSWNYI 165
Cdd:cd17473 79 GVAGL--FLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 166 FWInvpvgiiayflgshalpkekakgsvqevdfigsalmaltivflflginygqiagwsnpFVIGAIILAVILFVLFIRT 245
Cdd:cd17473 156 FLV----------------------------------------------------------YLLALPVLILVLLFLPEPA 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 246 ENRKSVPLIDLGIFKSKLFSLSVLTAMLNFTAAMF---VNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLS 322
Cdd:cd17473 178 RKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLfyvIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLK 257
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1391035794 323 DKYDKELITFIgisGIIIAQLGYLSISGNTPYGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLA 398
Cdd:cd17473 258 RRLGKRRLLAI---GFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSA 330
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
10-182 |
1.04e-16 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 81.54 E-value: 1.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 10 ISIGIFIFMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLA 89
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 90 GINLgwGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRAR-AMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWI 168
Cdd:cd17476 81 GFSP--NFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNiVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWF 158
|
170
....*....|....*...
gi 1391035794 169 N----VPVGIIAYFLGSH 182
Cdd:cd17476 159 LailaAIVAVAAIFWTSP 176
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
17-410 |
5.62e-16 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 79.20 E-value: 5.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 17 FMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLAGINLGWG 96
Cdd:cd06173 9 LLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 97 ---LPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWINVpvg 173
Cdd:cd06173 89 slsLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA--- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 174 iiayflgshalpkekakgsvqeVDFIGSALMALTIVFLFLGINYGQIAGWSNPFVIGAIILavilfvlfirtenrksvpl 253
Cdd:cd06173 166 ----------------------LSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYL------------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 254 idlgiFKSKLFSLSVLTAMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDKELITFI 333
Cdd:cd06173 205 -----RRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLI 279
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1391035794 334 GISGIIIAqlgYLSISGNTPYGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIAFVLGTSLA 410
Cdd:cd06173 280 GALLLGLA---LLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLA 353
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
198-414 |
9.10e-16 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 79.18 E-value: 9.10e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 198 FIGSALMALTIVFLFLGINYGQIAGWSNPFVIGAIILAVILFVLFIRTENR-----KSVPLIDL--GIFKSKLFSLSVLT 270
Cdd:COG2211 157 GLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERpvpeeEKVSLKESlkALLKNRPFLLLLLA 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 271 AMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDKELITFIGISGIIIAQLGYLSISG 350
Cdd:COG2211 237 YLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGP 316
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1391035794 351 NTPYGFvIAALALHGLSVGFFQSPNNALVMSTVDKKYL-------GIAGSVNSLARNIAFVLGTSLATISL 414
Cdd:COG2211 317 GNLWLL-LVLAALAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLLL 386
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
12-185 |
1.26e-15 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 78.39 E-value: 1.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 12 IGIFIFMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFlaGI 91
Cdd:cd17323 4 ISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI--GC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 92 NLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWINVP 171
Cdd:cd17323 82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAI 161
|
170
....*....|....
gi 1391035794 172 VGIIAYFLGSHALP 185
Cdd:cd17323 162 ISGFCLILIFLFLP 175
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-414 |
1.53e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 72.07 E-value: 1.53e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 12 IGIFIFMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLAGi 91
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 92 nLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQI--TSWNYIFWIN 169
Cdd:cd06174 80 -FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 170 VPVGIIAYFLGSHALPKEKAKGSVQEVDFIGSALMALTIVflflginygqiagwsnpfvigaiilavilfvlfirtenrk 249
Cdd:cd06174 159 AALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKR---------------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 250 svplidlgIFKSKLFSLSVLTAMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDKEL 329
Cdd:cd06174 199 --------VLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRK 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 330 ITFIGisGIIIAQLGYLSISGNTPYGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIAFVLGTSL 409
Cdd:cd06174 271 PLLLI--GLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLL 348
|
....*
gi 1391035794 410 ATISL 414
Cdd:cd06174 349 AGFLL 353
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
29-322 |
5.50e-13 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 70.11 E-value: 5.50e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 29 ALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFlaGINLGWGLPFLLFARIVQA 108
Cdd:TIGR00710 27 AFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSL--GLALSNNIETLLVLRFVQA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 109 VGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWINVPVGIIAYFLGSHALPKEK 188
Cdd:TIGR00710 105 FGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 189 AKgsvqeVDFIGSALMALTIVFLFLGINYgqiagWSNPFVIGAIilAVILFVLFIRTenrksvPLIDLGIFKSKLFSLSV 268
Cdd:TIGR00710 185 PY-----EARIQISTYFETFLLLLKSKMF-----WGYALIYGAS--FGGFFAFFSGA------PFVYIDIMGVSPSVFGL 246
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1391035794 269 LtAMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLS 322
Cdd:TIGR00710 247 L-FALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGS 299
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
10-410 |
2.36e-12 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 68.00 E-value: 2.36e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 10 ISIGIFIFMSTLdgSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLA 89
Cdd:cd17489 1 ILLANFFFFLSF--YLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 90 GINLGWGLpfLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWIn 169
Cdd:cd17489 79 LLATSVAL--LLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 170 vpvgiiayflgshalpkekakgsvqevdfigSALMALTIVFLFLGINYgqiagwsnpfvigaiilavilfVLFIRTENRK 249
Cdd:cd17489 156 -------------------------------AAVLALLALLLVFLVKD----------------------PPPVAAEEAE 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 250 SVPLIDLGIFKSKLFSLSVLTAMLNFTAAMFVNILMPFFLQdyHGLSAgvAGLMMTAYPVAMLISSPISGVLSDKYDKel 329
Cdd:cd17489 183 AGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAE--RGISN--AGLFFTVYAIALLLSRPFSGKLSDRKGP-- 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 330 iTFIGISGIIIAQLGYLSISGNTPYGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIAFVLGTSL 409
Cdd:cd17489 257 -KTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLL 335
|
.
gi 1391035794 410 A 410
Cdd:cd17489 336 L 336
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
5-410 |
1.89e-11 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 66.18 E-value: 1.89e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 5 RILALISIGIFIFMSTLDGSIVNV----ALPTMSRELQVSLAQVtwvvtIYLIVISAVILIFGRLGDLLGKANVFRTGAI 80
Cdd:cd17322 1 LIILFFSLFLCGFAIGLDGQIRYSyqayATSSFSKHSLLSTINV-----VNNIVSAVSQPPYAKLSDVFGRLELFLVSLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 81 IFTIGSFLaginlgwglpfLLFARIVQA-VGGSMFMA---TSFGLVAQIFPPET-----RARAMAINSMFVSVGSIAGPA 151
Cdd:cd17322 76 LYVVGTII-----------MAASTNVQTyAAGSVFYNagyTGLNLLLTLILADFsslknRGFASAIPSLPYIITTWIGGN 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 152 I--GGLILQITSWNYIFW-INVP-VGIIAYFLGSHALPKEKAKGS-----------------------VQEVDFIGSALM 204
Cdd:cd17322 145 IaqAALPNSNWRWGYGMWaIILPlSSLPLVLCLLYMQRKARKDGEikelknqeteeqtgglsqnlvklFWKLDIFGVILL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 205 A--LTIVFLFLGINYGQIAGWSNPFVIGAIILAVILFVLFIRTENRKS-VPLIDLGIFKSKLFSLSVLTAMLNFTAAMFV 281
Cdd:cd17322 225 TagLGLILVPLTLAGGAKSKWKNSSIIAMIVLGGVLLVAFLLWEAKFAkYPFLPFRLLKDRTILAACLIDFFYFFSYYIF 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 282 NILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDK-ELITFIGISGIIIAQLG-YLSISGNTPYGFVIA 359
Cdd:cd17322 305 SDYLYTVLQVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKTRRyKVLVIIGVPLYIVGMGLlIRYRGGSGSHGGIIG 384
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 1391035794 360 ALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIAFVLGTSLA 410
Cdd:cd17322 385 ALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAIS 435
|
|
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
25-410 |
2.00e-11 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 65.42 E-value: 2.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 25 IVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVF-RTGAIIFTIGSFLAGINLGWGLPF--LL 101
Cdd:TIGR00900 17 ITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMiGADLIRAVLVAVLPFVALLGGLNIwqVY 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 102 FARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWINVpvgiiayflgs 181
Cdd:TIGR00900 97 VLAGILAIAQAFFTPAYQAMLPDLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWAIWVDA----------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 182 halpkekakgsvqeVDFIGSALMALTivflflgINYGQIAGWSNPFVIGAIILAVILFVLFIRTENRksvplidlgifks 261
Cdd:TIGR00900 166 --------------VGFAISALLIVS-------VRIPELAASEIQALSNAVLRDTREGIKFVLKNPL------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 262 kLFSLSVLTAMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDKELITFIGISGIIIA 341
Cdd:TIGR00900 212 -LRTLLLLALLFNLVFAPAIVALFPYVQSKYLGRGSTHYGWVLAAFGLGALLGALLLGLLGRYFKRMALMTGAIFVIGLA 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1391035794 342 QLGYLSISGNTPyGFVIAALALhGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIAFVLGTSLA 410
Cdd:TIGR00900 291 ILVVGLTPPNFP-LFLVLWFAI-GVGYGPINVPQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLGLILA 357
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
2-363 |
2.15e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 65.26 E-value: 2.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 2 QKNRILALISIGIFIFMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAII 81
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 82 FTIGSFLAGinLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPpETRARAMAINSMFVSVGSIAGPAIGGLilqits 161
Cdd:COG0738 83 MALGLLLFA--LAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGL------ 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 162 wnyifwinvpvgiiayflgshalpkekakgsvqevdfigsalmaltivFLFLGINygqiAGWSNPFVIGAIILAVILFVL 241
Cdd:COG0738 154 ------------------------------------------------LILLGLS----LSWHLPYLILAVLLLLLALLF 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 242 FI--------RTENRKSVPLIDLGIFKSKLFSLSVLTAMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLI 313
Cdd:COG0738 182 LRsklpeieeEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTI 261
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1391035794 314 SSPISGVLSDKYDkeLITFIGISGIIIAQLGYLSISGNTPYGFVIAALAL 363
Cdd:COG0738 262 GRFLGGFLLKRFG--PVRLLRLSALLAAVGLLLALLAPGPWLALIGLALV 309
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
5-179 |
1.30e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 56.42 E-value: 1.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 5 RILALISIGIFIfmSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTI 84
Cdd:cd17319 3 RIIPLLFLAYVI--NYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 85 GSFLAGinLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNY 164
Cdd:cd17319 81 FTALTG--FATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRW 158
|
170
....*....|....*....
gi 1391035794 165 IFWI----NVPVGIIAYFL 179
Cdd:cd17319 159 AFIIegllGLLLAVLWWFY 177
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
6-179 |
3.42e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 55.26 E-value: 3.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 6 ILALISIGIFIFMSTLDGSIVNVALPT-MSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTI 84
Cdd:COG2271 179 LLRFWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 85 GSFLAGINLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNY 164
Cdd:COG2271 259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170
....*....|....*
gi 1391035794 165 IFWINVPVGIIAYFL 179
Cdd:COG2271 339 AFLLLAALALLAALL 353
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
13-181 |
4.36e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 54.90 E-value: 4.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 13 GIFIFMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLAGin 92
Cdd:cd17365 5 FLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTA-- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 93 LGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWIN-VP 171
Cdd:cd17365 83 FAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGgVP 162
|
170
....*....|
gi 1391035794 172 VGIIAYFLGS 181
Cdd:cd17365 163 PLILLPLLRG 172
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
28-179 |
6.80e-08 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 54.64 E-value: 6.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 28 VALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLAGINLGWGLpfLLFARIVQ 107
Cdd:PRK10473 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSL--FLAGRFLQ 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1391035794 108 AVGGSMFMATSFGLVAQIFPPETRARAM-AINSMFVSVGSIAgPAIGGLILQITSWNYIFWINVPVGIIAYFL 179
Cdd:PRK10473 102 GIGAGCCYVVAFAILRDTLDDRRRAKVLsLLNGITCIIPVLA-PVLGHLIMLKFPWQSLFYTMAAMGILVLLL 173
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
9-371 |
7.61e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 54.14 E-value: 7.61e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 9 LISIGIFIFMSTLDGSIVNVALPTMSRE--LQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGS 86
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 87 FLAGinLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGpaigglilqitswnyif 166
Cdd:cd17316 81 LLIG--LLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLA----------------- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 167 winvpvgiiayflgshalpkekakgsvqevdfigsalmalTIVFLFLGINYGQIAGWSNPFVIGAIIlavILFVLFIRte 246
Cdd:cd17316 142 ----------------------------------------ALVASLLIPLLSGDWGWRILFLIGALP---ALLALLLR-- 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 247 nrksvplidlgifksKLFSLSVLTAMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYD 326
Cdd:cd17316 177 ---------------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIG 241
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1391035794 327 KELITFIGISGIIIAQLGYLSISGNTPYGFVIAALALHGLSVGFF 371
Cdd:cd17316 242 RKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVW 286
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
36-176 |
8.59e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 54.09 E-value: 8.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 36 ELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLAGINLGWGLPFLLFarIVQAVGGSMFM 115
Cdd:cd17370 228 ELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGF--ILWGLYMGAQE 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1391035794 116 ATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWINVPVGIIA 176
Cdd:cd17370 306 SIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIA 366
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
29-188 |
1.08e-07 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 53.77 E-value: 1.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 29 ALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSF-LAGINlgwGLPFLLFARIVQ 107
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVaCALAQ---TIDQLIYMRFLH 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 108 AVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWINVPVGIIAYFLGS----HA 183
Cdd:PRK11102 90 GLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFffipET 169
|
....*
gi 1391035794 184 LPKEK 188
Cdd:PRK11102 170 LPKER 174
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
21-182 |
1.13e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 53.85 E-value: 1.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 21 LDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLAGINLGWGLpfL 100
Cdd:cd17371 13 FDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ--L 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 101 LFARIVQAVG-GSMFMATSFgLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQI----TSWNYIFWINVPVGII 175
Cdd:cd17371 91 LILRALAGLGfGGEWAAGAA-LMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLlppeIAWRVLFLLGALPALL 169
|
....*..
gi 1391035794 176 AYFLGSH 182
Cdd:cd17371 170 VLFIRRF 176
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
8-166 |
1.83e-07 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 52.94 E-value: 1.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 8 ALISIGIFIfmSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSF 87
Cdd:cd17380 2 ILLFLATCI--CYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATL 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1391035794 88 LAGINLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIF 166
Cdd:cd17380 80 LTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVF 158
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
39-370 |
3.55e-07 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 52.22 E-value: 3.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 39 VSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGaiIFTIGS------FLAGINLGwgLPFLLFA---RIVQAV 109
Cdd:cd17385 31 VSDTIIGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAG--MFVSGGctilfgFLDRVPDG--TVFIALCflvRIVEAV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 110 GGSMFMATSFGLVAQIFpPETRARAMAINSMFVSVGSIAGPAIGGlilqitswnyifwinvpvgiiayflgshalpkeka 189
Cdd:cd17385 107 GFAAFITASFAIIAKEF-PNNIATVLGTLETFSGLGLMLGPPLGG----------------------------------- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 190 kgsvqevdfigsalmaltivFLFlginygQIAGWSNPF-VIGAIILAVILFVLFI-----RTENRKSVPLIDLGIFKSKL 263
Cdd:cd17385 151 --------------------FLY------QAGGYELPFlVLGCLLLLTVPLNMFIlprydDDPSPKSGSMLKLLKIPSVL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 264 FSLSVLTAMLNFTAamFVNILMPFFLQDYHgLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDKELITFigISGIIIAQL 343
Cdd:cd17385 205 LLCLSIVSGSVSLG--FLDPTLSPHLRQFK-LSPGQVGLMFLILAGSYAISAPLWGWLSDKKKIPKWLM--VIGSIITGV 279
|
330 340 350
....*....|....*....|....*....|...
gi 1391035794 344 GYLSIS------GNTPYGFVIAALALHGLSVGF 370
Cdd:cd17385 280 GFLLLGpapllpIKSELWMVIIGLVLLGLSLGA 312
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
259-412 |
5.15e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.51 E-value: 5.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 259 FKSKLFSLSVLTAMLNFTAAMFVNILMPFFLQDYhGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDKELITFIGISGI 338
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1391035794 339 IIAQLGYLSISGntpYGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIAFVLGTSLATI 412
Cdd:COG2814 86 ALGSLLCALAPS---LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
21-179 |
1.66e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 50.31 E-value: 1.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 21 LDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLAGINLGWGLpfL 100
Cdd:cd17328 13 MDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQ--L 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 101 LFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQIT-SWNYIFWINVPVGIIAYFL 179
Cdd:cd17328 91 LLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAIL 170
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
8-341 |
3.23e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 49.10 E-value: 3.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 8 ALISIGIFIFMSTLDGSIVNVA--LPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIG 85
Cdd:COG2807 17 WLLLLAIVLVALNLRPAITSVGplLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 86 SFLAGinLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFpPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNyi 165
Cdd:COG2807 97 LLLRS--LAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWR-- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 166 fwinvpvgiiayflgshalpkekakgsvqevdfigSALMALTIVflflginygqiagwsnpfVIGAIILAVILFVLFIRT 245
Cdd:COG2807 172 -----------------------------------GALAVWALL------------------ALLALLLWLPLLRRRPAA 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 246 ENRKSVPLIDLGIFKSKLFSLSVLTAMLNFTAAMFVNILMPFFLQDyHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKY 325
Cdd:COG2807 199 AAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRL 277
|
330
....*....|....*.
gi 1391035794 326 DKELITFIGISGIIIA 341
Cdd:COG2807 278 GDRRPLLLLLGLLGLA 293
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
268-410 |
3.27e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 49.15 E-value: 3.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 268 VLTAMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDKELITfigISGIIIAQLGYLS 347
Cdd:cd17329 5 LIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVM---LAGLLLRALGFAL 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1391035794 348 IS-GNTPYGFVIAALALhGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIAFVLGTSLA 410
Cdd:cd17329 82 LGfAHSPWLFAIALVLT-GFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLG 144
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
3-146 |
5.31e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.43 E-value: 5.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 3 KNRILALISIGIFIFMSTLdGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIF 82
Cdd:COG2814 205 RRPRLLLLLLLAFLLGFGF-FALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1391035794 83 TIGsfLAGINLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGS 146
Cdd:COG2814 284 ALG--LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
7-244 |
5.39e-06 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 48.67 E-value: 5.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 7 LALIsigIFIFMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGS 86
Cdd:PRK15403 19 MALI---LYDFAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLAC 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 87 flAGINLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIF 166
Cdd:PRK15403 96 --AATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLF 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 167 WINVPVGIIAYFLGSHALPKEKAKGSV----------------QEVDFIGSALMALTIVFLFL-------------GINY 217
Cdd:PRK15403 174 AIIAVMGLIAFVGLLLAMPETVKRGAVpfsaksvlrdfrnvfrNRLFLTGAATLSLSYIPMMSwvavspvilidagGMTT 253
|
250 260
....*....|....*....|....*..
gi 1391035794 218 GQIAgWSNPFVIGAIILAVILFVLFIR 244
Cdd:PRK15403 254 SQFA-WTQVPVFGAVIVANAIVARFVK 279
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
60-179 |
9.39e-06 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 47.61 E-value: 9.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 60 LIFGRLGDLLGKANVFRTGAIIFTIGSFLAGINLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINS 139
Cdd:cd17318 74 IPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAY 153
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1391035794 140 MFVSVGSIAGPAIGGLILQITSWNYIFWINVPVGIIAYFL 179
Cdd:cd17318 154 SGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLL 193
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
269-412 |
1.11e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.41 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 269 LTAMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDKELITFIGISGIIIAQLGYLSI 348
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1391035794 349 SGNTpygFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIAFVLGTSLATI 412
Cdd:pfam07690 83 SSLW---LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGL 143
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
269-406 |
1.72e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 46.80 E-value: 1.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 269 LTAMLNFTAAMFVNILMPFFLQDYhGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDKELITFIGISGIIIAQLGYLSI 348
Cdd:cd17325 3 LALFLDMLGYGIIIPILPLYAESL-GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1391035794 349 sgnTPYGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIAFVLG 406
Cdd:cd17325 82 ---TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIG 136
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
199-462 |
2.51e-05 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 46.53 E-value: 2.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 199 IGSALMAL--TIVFLFLGINYGQIAGWSNPFVIGAIILAVILFVLFIRTENR------------KSVPLIDL--GIFKSK 262
Cdd:pfam13347 145 GGGLLAAAlaFPLVLILGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERvsmrskedtgqkEAGSLLDMlkEVFRNR 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 263 LFSLSVLTAMLNFTAAMFVNILMPFFLQDYHGlSAGVAGLMMTAYPVAMLISSPISGVLSDKYDKELITFIGISGIIIAQ 342
Cdd:pfam13347 225 AFLILLASFLLAALAMGVLNGLLLYYFRYVLG-NGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGF 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 343 LGYLSISGNtPYGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYL-------GIAGSVNSLARNIAFVLGTSLATISLF 415
Cdd:pfam13347 304 ALALLLGPN-NTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGELrtgkrreGTFFAMWSFISKLATGVGLGVSGLLLS 382
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1391035794 416 FAmsslagrHITTYIASQPKLFLDGMHISLFVSLVLVIITWILSLMR 462
Cdd:pfam13347 383 AF-------GYNAGDSVQSPQAVTAIRLLYAVLPAVLFLVALLLLYF 422
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
9-179 |
2.95e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.06 E-value: 2.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 9 LISIGIFIFMSTLDGSIVNVALPT-MSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSF 87
Cdd:cd17316 179 TLLLILLWFFISFGYYGLTTFLPTyLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILAL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 88 LAGINLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFW 167
Cdd:cd17316 259 PLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPA 338
|
170
....*....|..
gi 1391035794 168 INVPVGIIAYFL 179
Cdd:cd17316 339 LILALLAIVALI 350
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
22-185 |
4.21e-05 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 45.64 E-value: 4.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 22 DGSIVNVALPTMSRELQVSLAQVTWVVTIylIVISAVI--LIFGRLGDLLGKANVFRTGAIIFTIGSFLAGinLGWGLPF 99
Cdd:cd17359 16 DTGVINGALPFLQTDFNLTPFLEGLVVSS--ALLGAAIgaLFAGRLADRFGRRKTLLISAVLFFISALGSA--FSPNFTI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 100 LLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIA--------GPAIGGLILQITSWNYIFWINVp 171
Cdd:cd17359 92 FIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLayivnyliANAGGADWLGAEGWRWMLGLEA- 170
|
170
....*....|....
gi 1391035794 172 VGIIAYFLGSHALP 185
Cdd:cd17359 171 IPAILFLLGMLFIP 184
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
9-406 |
5.14e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 45.34 E-value: 5.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 9 LISIGIFIFMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFL 88
Cdd:cd17355 5 LAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 89 AGInLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWnyifwi 168
Cdd:cd17355 85 LAL-ATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGW------ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 169 nvpvgiiayflgSHAlpkekakgsvqevdFIGSALMALTIVFLFLginygqIAGWSNPFVIGAIILAVILFvlfirtenr 248
Cdd:cd17355 158 ------------RTA--------------LLVLALLALLVLVPVL------LLLRRRPADLALRAYDDASP--------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 249 KSVPLIDLGIFKSKLFSLSVLT-AMLNFTAAMFVNILMPFFLQdyHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDK 327
Cdd:cd17355 197 ASPGSTLKEALRSASFWLLALAfFLCGFAVVGLIVHLVPYLAD--RGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSP 274
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1391035794 328 ELITFIGISGIIIAQLGYLSISgnTPYGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIAFVLG 406
Cdd:cd17355 275 RRLLAASYALRALGLALLLLLP--FPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALG 351
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
62-289 |
5.70e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 45.28 E-value: 5.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 62 FGRLGDLLGKANVFRTGAIIFTIGSFLAGI--NLGWglpfLLFARIVQAVG--GSMFMAtsfgLVAQIFPPETRARAMAI 137
Cdd:cd17472 52 FGLLSDRIGRKPVILFGLLLFIAGSLLAAYatSIYG----LILGRALQGSGaiSSVVMA----LLADLTREENRTKAMAL 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 138 NSMFVSVGSIAGPAIGGLILQITSWNYIFWINVPVGIIAYFLGSHALP--------KEKAKGSVQEV---------DFIG 200
Cdd:cd17472 124 IGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPdppkivqiSEKEKKKLKKLlknkrllrlDFSI 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 201 SALMALTIVFLFLGINYGQIAGWSNPFV----IGAIILAVILFVLFIRTENRK--------------SVPLIDLGIFKSK 262
Cdd:cd17472 204 FILHFVLMAFFYILPLLLTQLGGGKGQLwkvyLPAILIGFILMVPFVIYAEKKgkmkqvfvssilliAVGFLLLLFAATS 283
|
250 260
....*....|....*....|....*..
gi 1391035794 263 LFSLSVLTAMLnFTAAMFVNILMPFFL 289
Cdd:cd17472 284 LWLLIIGLIIF-FIGFNLLEALLPSLV 309
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
25-423 |
6.02e-05 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 45.69 E-value: 6.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 25 IVNVALPTMSRELQVSL-AQVTWVVTIYLIVISAVIlifGRLGDLLGKANVFRTGAIIFTIGSFLAGINLGWGLPFLLFA 103
Cdd:PRK08633 32 IQNTLIKAYDGSEQVILtAIVNALFLLPFLLLSSPA---GFLADKFSKNRVIRIVKLFEVGLTLLIVLAYYLGWFWLAFA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 104 RIV-QAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSwnyifwinvpVGIIAYFLGSH 182
Cdd:PRK08633 109 VTFlLGAQSAIYSPAKYGIIPELVGKENLSRANGLLEAFTIVAILAGTALFSFLFESVN----------GNTPSEILGRI 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 183 AlpkekakgsvqevdFIGSALMALTIVflflginyGQIAGWSNPFVIGAIILAVILFVLFIRTENRKSVPLidlgIFKSK 262
Cdd:PRK08633 179 A--------------PAGLVLLAVAVL--------GLIFAYRLPKVPAAAPEVFDKKKYLFPKLLWRNLKL----LRSDR 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 263 LFSLSVL-TAMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDKELITFIGISGIIIA 341
Cdd:PRK08633 233 VLWLAIIgLSYFWFISQLAQANFPAYAKEVLGLDNTFQVQYLLAASAIGIGIGSLLAGRLSGRHIELGLVPLGALGLALS 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 342 QLgYLSISGNTPygFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLG--IAGsvNSLARNIAFVLGTSLATISLFFAMS 419
Cdd:PRK08633 313 LF-LLPTAPSLA--SVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELGkvLAA--NNFLQNVGMLLFLALTTLFSGLGLS 387
|
....
gi 1391035794 420 SLAG 423
Cdd:PRK08633 388 PAGL 391
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
36-410 |
8.89e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.46 E-value: 8.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 36 ELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFR-TGAIIFTIGSFLAGINLGWGLpfLLFARIVQAVGGSMF 114
Cdd:cd17370 28 VLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLViLGYGLSALAKPLLALAGSWQL--VLLLRILERLGKGIR 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 115 MATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYifwinvpvgiiayflgshalpkekakgsvq 194
Cdd:cd17370 106 TPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNY------------------------------ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 195 evdfigsalmalTIVFLFLGINYgqiagwsnpfvigaiILAVILFVLFIRTENRKSVPLIDLGIFKSKLFSLS---VLTA 271
Cdd:cd17370 156 ------------RTIFLLAAIPA---------------LLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAfwlYLLA 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 272 MLNFTAAMFVNILMPFFLQDyHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDKELITFIGIsgiIIAQLGYLSISGN 351
Cdd:cd17370 209 VALFALGNFSFAFLILRAQE-LGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGY---LSLALAYLGFALG 284
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1391035794 352 TPYGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIAFVLGTSLA 410
Cdd:cd17370 285 SSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIA 343
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
7-164 |
9.47e-05 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 44.97 E-value: 9.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 7 LALISIGIFIFmstldgsIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGS 86
Cdd:TIGR01299 174 LALMADGVEVF-------VVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFA 246
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1391035794 87 FLAGINLGWGlpFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNY 164
Cdd:TIGR01299 247 FFSSFVQGYG--FFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGWSF 322
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
1-176 |
9.60e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.53 E-value: 9.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 1 MQKNRILALISIGIFIFMSTLDGsiVNVALPT-MSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGA 79
Cdd:cd17329 196 VLRDRAFLLFLLASFLISLIYFQ--LESTLPVyVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGI 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 80 IIFTIGsfLAGINLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQI 159
Cdd:cd17329 274 LLFAIG--FAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDL 351
|
170
....*....|....*..
gi 1391035794 160 TSWNYIFWINVPVGIIA 176
Cdd:cd17329 352 LGPGLPWLILAALGLIA 368
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
33-220 |
1.10e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.14 E-value: 1.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 33 MSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGsfLAGINLGWGLPFLLFARIVQAVGGS 112
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALG--FALLGFAHSPWLFAIALVLTGFGGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 113 MFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQItSWNYIFWINVPVGIIAYFLGSHALPKEKAKGS 192
Cdd:cd17329 104 LFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLLAALVLLFLLPETRPKRR 182
|
170 180 190
....*....|....*....|....*....|....*..
gi 1391035794 193 VQEVDFIGS---------ALMALTIVFLFLGINYGQI 220
Cdd:cd17329 183 AAEKTEILRgykivlrdrAFLLFLLASFLISLIYFQL 219
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
199-417 |
1.13e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 44.52 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 199 IGSALMALTIVFLFLGINYGQIA-GWSNPFVIGAIILAVILFVLFIRTENRKSVP---------LIDLG-IFKSKLFSLS 267
Cdd:cd17332 147 IGGLLVTVLPPPLVAYFGGGNASrGYFLTALIIGIIGIILLLICFFGTRERVVPPeeeksklplLKSLKaLLKNRPFLIL 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 268 VLTAMLNFTAAMFVNILMPFFLQdYHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDKELITFIGISGIIIAQLGYLS 347
Cdd:cd17332 227 LLAYLLYFLAFNIVNTVLVYYFK-YVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFF 305
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1391035794 348 ISGNTPYGFVIAAlALHGLSVGFFQSPNNALVMSTVDKKYL-------GIAGSVNSLARNIAFVLGTSLATISLFFA 417
Cdd:cd17332 306 LPPGNLVLILVLA-VLAGIGYGGANLLPWAMLADVIDYGELktgkrreGIFYSVMTFFRKLGLALAGALVGLILSLA 381
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
24-370 |
1.34e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.08 E-value: 1.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 24 SIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGaiIFTIGSFLAGINLGWGLPFLLFA 103
Cdd:cd17478 13 GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLG--PLLTGLGLSLLGFAPNYWLLLLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 104 RIVQAVGGSMFMATSFGLVAQIFPPEtRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWINVPVGIIayflgsha 183
Cdd:cd17478 91 VALAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLA-------- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 184 lpkekakgsvqevdfigSALMALTIVFLFLGINYGQIAGWSNPFVIGAIILAVILFVLFIrtenrksvplidlgIFKSkl 263
Cdd:cd17478 162 -----------------VALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIV--------------FLRS-- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 264 fslSVLTAMLNFtaamfvnilMPFFLQDyHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDKELITFIGISGIIIAQL 343
Cdd:cd17478 209 ---WVLSSLTTF---------LPFYLVQ-RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLL 275
|
330 340
....*....|....*....|....*..
gi 1391035794 344 GYLsisgNTPYGFVIAALALHGLSVGF 370
Cdd:cd17478 276 LFL----LTPGIWSYILLVLAGFLLFA 298
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
39-371 |
1.59e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 43.70 E-value: 1.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 39 VSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLAGINLGwgLPFLLFARIVQAVGGSMFMATS 118
Cdd:cd17477 28 VSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS--PWVWFLLRFVMGIGLAGLFVVS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 119 FGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIgglilqitswnyifwinvpvgiiayflgshalpkekakgsvqevdf 198
Cdd:cd17477 106 ESWLNALATNENRGRVLGLYSTVLGLGFALGPLL---------------------------------------------- 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 199 igsalmaltivflflgINYGQIAGWSNPFVIGAIILAVILFVLFIRTENRKSVPLIDLGIFksKLFSLSVLTAMLNFTAA 278
Cdd:cd17477 140 ----------------LALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEEAESISLR--RLLRIAPLALLGAFVAG 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 279 MFVNI---LMPFFLQDyHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDKeLITFIGISGIIIAQLGYLSISGNTPYG 355
Cdd:cd17477 202 FLEGAfysLLPLYGLR-LGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDR-RRVLLGCALLGALAALLLPLVPGLPLA 279
|
330
....*....|....*.
gi 1391035794 356 FVIAALALHGLSVGFF 371
Cdd:cd17477 280 LLVLLFLWGGAAGPLY 295
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
27-327 |
1.97e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 43.42 E-value: 1.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 27 NVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIftigSFLAGINLGWG--LPFLLFAR 104
Cdd:cd17312 23 SVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLL----SALANIFMGFStsLWFFAVLW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 105 IVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFwinvpvgiiayflgshal 184
Cdd:cd17312 99 GLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF------------------ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 185 pkekakgsvqevdFIGSALMALTIVFLFLGINYgqiagwSNPFVIgaIILAVILFVLFIRTEnrksvplidlgifksklf 264
Cdd:cd17312 161 -------------LVPGIVGLVVAIILFFFLRD------SPPYVW--VLSLAYAFVYIVRYA------------------ 201
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1391035794 265 slsvltamlnftaamfVNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDK 327
Cdd:cd17312 202 ----------------CLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFG 248
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
49-179 |
4.25e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.58 E-value: 4.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 49 TIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGsfLAGINLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPP 128
Cdd:cd17489 234 TVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALG--LLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPP 311
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1391035794 129 ETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWINVPVGIIAYFL 179
Cdd:cd17489 312 HRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
222-431 |
4.45e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 42.51 E-value: 4.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 222 GWSNPFVIGAIILAVIL-----------FVLFIRTENRKSVPLIDLGIFKSKLFSLSVLTAMLNFTAAMFVNILMPFFLQ 290
Cdd:cd17369 177 GWRIPFLLSAVLVAVGLyirlrleetpvFRRAKEAGQVVRAPLVEVLRRHWRALLLAIGLRLAENVLFYLFTTFALSYAT 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 291 DYHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYD-KELITFIGISGIIIAQLGYLSISGNTPYGFVIAALALHGLSVG 369
Cdd:cd17369 257 QTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGrRPVYLAGALLAALFAFPFFWLLDTGSTWLIVLAAVVVLGVLHG 336
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1391035794 370 FFQSPNNALV--MSTVDKKYLGIagsvnSLARNIAFVLGTSLAtisLFFAMSSLAGRHITTYIA 431
Cdd:cd17369 337 MMYGPQAAFLaeLFPTRVRYTGA-----SLGYQLGAILGGGFA---PLIATALVAATGSWWPVA 392
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
29-185 |
5.25e-04 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 42.20 E-value: 5.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 29 ALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLAgiNLGWGLPFLLFARIVQA 108
Cdd:PRK11652 30 AIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVA--LFAHSLTVLIAASAIQG 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1391035794 109 VGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWINVPVGIIAYFLGSHALP 185
Cdd:PRK11652 108 LGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMP 184
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
16-185 |
5.25e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.18 E-value: 5.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 16 IFMSTLDGSIVNVALPTMSRE---LQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLAGin 92
Cdd:cd17330 5 VFLDALGFGIVFPVLPFYVREfnkLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLG-- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 93 LGWGLPFLLFARIVQAVGGSMFmATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWINVPV 172
Cdd:cd17330 83 LSRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAAL 161
|
170
....*....|...
gi 1391035794 173 GIIAYFLGSHALP 185
Cdd:cd17330 162 ALLNLVLVLFFLP 174
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
9-137 |
6.66e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 41.74 E-value: 6.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 9 LISIGIFIFMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFL 88
Cdd:cd17369 231 LLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFP 310
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1391035794 89 A--GINLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAI 137
Cdd:cd17369 311 FfwLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASL 361
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
3-175 |
6.85e-04 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 41.82 E-value: 6.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 3 KNRILALISIGIFIFMSTLdgSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIF 82
Cdd:cd17472 192 KNKRLLRLDFSIFILHFVL--MAFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVSSILL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 83 TIGSFLAGINLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSW 162
Cdd:cd17472 270 IAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGY 349
|
170
....*....|...
gi 1391035794 163 NYIFWINVPVGII 175
Cdd:cd17472 350 SSVFLTILILALL 362
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
12-179 |
6.96e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.79 E-value: 6.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 12 IGIFIFMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIY-LIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLAG 90
Cdd:cd17330 180 LLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVgIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLP 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 91 InlGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWINV 170
Cdd:cd17330 260 F--ASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAA 337
|
....*....
gi 1391035794 171 PVGIIAYFL 179
Cdd:cd17330 338 GLLLIALFL 346
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
191-379 |
7.64e-04 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 41.90 E-value: 7.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 191 GSVQEVDFIGSALMALTIVFL---FLGINYGQIAGWSNPFVIGAiILAVilFVLFIR--------TENRKSVPLIDLGIF 259
Cdd:cd17367 139 SSFQYVTLIGGQLLALGVLLVlqhTLGEDQMAAWGWRIPFLLGG-VLAV--VVLWLRrgleetesFEAIAESNEASAGTL 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 260 KSKLFSLSVLTAMLNFTAAMFV-----NILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYD-KELITFI 333
Cdd:cd17367 216 RELRRHPRELLLVVGLTAGGTLafytwTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGrRPLLLFF 295
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1391035794 334 GISGiIIAQLGYLSISGNTPYGFVIAALALHGLSVGFFQSPNNALV 379
Cdd:cd17367 296 GIGG-TLATVPLLSALDHTDSPYTAFALVLVGLVFLSGYTSINAVV 340
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
3-179 |
8.97e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 41.64 E-value: 8.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 3 KNRILALISIGIFIFMSTLdGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGD-LLGKANVFRTGAII 81
Cdd:cd06174 201 KNPGLWLLLLAIFLVNLAY-YSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 82 FTIGSFLAGINLGWGLPFLLFarIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQIT- 160
Cdd:cd06174 280 MALGLALLLLAPSLLLLLLLL--LLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATf 357
|
170
....*....|....*....
gi 1391035794 161 SWNYIFWINVPVGIIAYFL 179
Cdd:cd06174 358 GLTGAFLVLAVLLLLAAIL 376
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
192-324 |
9.13e-04 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 41.72 E-value: 9.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 192 SVQEVDFIGSALMALTIVFLF---LGINYGQIAGWSNPFVIGAIILAVILFVL--FIRTENRKSVPLIDLGIFKSKLFSL 266
Cdd:PRK10406 163 SFQYVTLIGGQLLALLVVVVLqqtLEDAELREWGWRIPFALGAVLAVVALWLRrqLDETSQQETRALKEAGSLKGLWRNR 242
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1391035794 267 SVLTAMLNFTAAMFVNIL-----MPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLSDK 324
Cdd:PRK10406 243 RAFIMVLGFTAAGSLCFYtfttyMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDK 305
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
262-411 |
1.09e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 41.01 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 262 KLFSLSVLTAMLNFTAAMFVNILMPFFLQDYhGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDKELITFIGIsgiIIA 341
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADL-GLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL---LLW 85
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 342 QLGYLSISGNTPYGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIAFVLGTSLAT 411
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLG 155
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
17-158 |
1.11e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 41.03 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 17 FMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDllgKANVFRTGAIIFTIGS-FLAGINLGW 95
Cdd:cd17365 181 FMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLAD---RFGPKRVLALFFALGAvSLALLGVSP 257
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1391035794 96 GLPFLLFARIVQA-VGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQ 158
Cdd:cd17365 258 ASLVLLYVLVFLAgACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLA 321
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
43-168 |
1.45e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 40.64 E-value: 1.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 43 QVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLAGINLGWglPFLLFARIVQAVGGSMFMATSFGLV 122
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSY--ELFLVLRFLVGVTSAGIFTVGFVLG 103
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1391035794 123 AQIFPPETRARAMAINSMFVSVGSIagpAIGGLILQITSWNYIFWI 168
Cdd:cd17317 104 MEIVGPKYRSFVGILFGLFWALGYM---LLALLAYLIRDWRWLQLA 146
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
222-325 |
1.49e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 40.82 E-value: 1.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 222 GWSNPFVIGAIILAVILFVLFIRTEN-----RKSVPLIDLGIFKSK----LFSLSVLTAMLNFTAAMFVNILMPFFLQDY 292
Cdd:cd17368 173 GWRIPFFIGLLIIPLGLWLRRSLEETeafleRKARPTRRELFALLAnnrrIILLGMLLVAGSTVTFYFTTVYTPTYAKTV 252
|
90 100 110
....*....|....*....|....*....|...
gi 1391035794 293 HGLSAGVAGLMMTAYPVAMLISSPISGVLSDKY 325
Cdd:cd17368 253 LGLSARDSFLVTLLAGVANFIWAPLGGALSDRI 285
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
29-432 |
1.64e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 40.81 E-value: 1.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 29 ALPTMSRELQVSLAQvTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLAGINLGWGLpfLLFARIVQA 108
Cdd:pfam06609 66 ALPNILQDIGQSENQ-GLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNT--LLAAMTLLG 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 109 VGGSMFMATSFgLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWINVPVGIIA-------YFLGS 181
Cdd:pfam06609 143 VAAGPAGASPL-FIGELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIAvlliiiwYHPPS 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 182 HAL---PKEKAKGSVQEVDFIGSALMALTIVFLFLGINYGQIAG--WSNPFVIGAIILAVILFVLFIRTE--NRKSVPLI 254
Cdd:pfam06609 222 FAQlhgKKARKRDELAKLDWIGIFLVIAGTSLFLLGVSWGGKPNnpWNSAKIIGLISSGAGSLVIFALYEvfGKPEQPII 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 255 DLGIFKSKLFSLSVLTaMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDKELITFIG 334
Cdd:pfam06609 302 PPALFKDTRGFVCILI-ISSIMGAMHLCLTIIYPQQVINIFGSSLKNWEETAWMSATASFGTGAGVMILGNLFHLIRHIR 380
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 335 ISGII-----IAQLGYLSISGNTPYGFVIAALALHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNIAFVLGTSl 409
Cdd:pfam06609 381 WQILVgalwlTAFLGAMSSINRDNKNAAIALSFFSGFVVAWAQDITMLLVQFITTDEDLGVAFAVVAAARPFAGSIFTA- 459
|
410 420
....*....|....*....|...
gi 1391035794 410 ATISLFfamSSLAGRHITTYIAS 432
Cdd:pfam06609 460 AFISLY---SNQYPKEIASHLSS 479
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
280-412 |
1.93e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 40.23 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 280 FVNILMPFFLQDYhGLSAGVAGLMMTAYPVAMLISSPISGVLSDKYDKELITFIgisGIIIAQLGYLSISGNTPYGFVIA 359
Cdd:cd17478 14 FLPALLPLLIAKL-GLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPL---GPLLTGLGLSLLGFAPNYWLLLL 89
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1391035794 360 ALALHGLSVGFFQsPNNALVMSTVDKKYLGIAGSVNSLARNIAFVLGTSLATI 412
Cdd:cd17478 90 LVALAGIGSAAFH-PEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAA 141
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
12-185 |
2.08e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 40.33 E-value: 2.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 12 IGIFIFMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLAG- 90
Cdd:pfam00083 16 TGVIGAFLTLIDFFKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGa 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 91 INLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGpAIGGLILQITS----WNYIF 166
Cdd:pfam00083 96 AKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLA-YIFGLGLNKTSnsdgWRIPL 174
|
170
....*....|....*....
gi 1391035794 167 WINVPVGIIaYFLGSHALP 185
Cdd:pfam00083 175 GLQLVPALL-LIIGLLFLP 192
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
3-164 |
2.19e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 40.25 E-value: 2.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 3 KNRILALISIGIFIFMSTLDGSivNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIF-GRLGDLLGKANVFRTGAII 81
Cdd:cd17503 176 KDRNFTLGLLLSFLLGLGLFGA--MFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLvGRLLDKFGPRLLLLAGLLL 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 82 FTIGSFL-AGINLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQIT 160
Cdd:cd17503 254 LALGTLLlAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNR 333
|
....
gi 1391035794 161 SWNY 164
Cdd:cd17503 334 TQFH 337
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
34-168 |
3.50e-03 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 39.87 E-value: 3.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 34 SRELQVSLAQVTWVVTiyLIVISAVI--LIFGRLGDLLGKANVFRTGAIIFTIGSFLagINLGWGLPFLLFARIVQAVGG 111
Cdd:cd17358 33 SLSLPLTVAQFSWFGS--LLTLGALIgaLLSGKLADRIGRKRTLLISAIPCILGWLL--IAFAKDVWMLYLGRFLAGFGG 108
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1391035794 112 SMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLIlqitSWNYIFWI 168
Cdd:cd17358 109 GAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFL----PWRTLALI 161
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
35-196 |
3.74e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.51 E-value: 3.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 35 RELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTI-GSFLAGInlgWGLPFLLF-ARIVQAVGGS 112
Cdd:cd17490 24 ESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTVlASLIMIL---FPSPWGLLiARFLSGIAAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 113 MFMATSFgLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWINVPVGIIA----YFLGSHALPKEK 188
Cdd:cd17490 101 TWVSFTV-LYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGfilsLFIKEERREKKP 179
|
....*...
gi 1391035794 189 AKGSVQEV 196
Cdd:cd17490 180 VLTELKEL 187
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
60-184 |
3.88e-03 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 39.69 E-value: 3.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 60 LIFGRLGDLLGKANVFRTGAIIFTIGSFLAGINLG------WGLPFLLFARIVQ--AVGGSMFMATSFglVAQIFPPETR 131
Cdd:PRK10642 75 LFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSyatigiWAPILLLLCKMAQgfSVGGEYTGASIF--VAEYSPDRKR 152
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1391035794 132 aramAINSMFVSVGSIAGPAIG-GLILQITS-----------WNYIFWINVPVGIIAYFLgSHAL 184
Cdd:PRK10642 153 ----GFMGSWLDFGSIAGFVLGaGVVVLISTivgeanfldwgWRIPFFIALPLGIIGLYL-RHAL 212
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
3-179 |
3.91e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.51 E-value: 3.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 3 KNRILALISI----GIFIFMSTLDGSIVNVAlptmsRELQVSLAQVTWVVTIYLIVISAVILIFGRL-GDLLGKANVFRT 77
Cdd:cd17490 192 KDKKLLFFSLlailQQMITFSTTFGFTPLIA-----KQLGASSFQLGLLSIIYLLPNALASLLSGTLfYKKLGERNTIII 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 78 GAIIFTIGSFLagINLGWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLIL 157
Cdd:cd17490 267 GFLLLGAYCFL--IPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIIS 344
|
170 180
....*....|....*....|..
gi 1391035794 158 QITSWNYIFWINVPVGIIAYFL 179
Cdd:cd17490 345 EAFGLQTGFFVIGVIALLAAIL 366
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
286-416 |
4.46e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 39.28 E-value: 4.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 286 PFFLQDYHGLSAGVAGLMMTAYPVAMLISSPISGVLSDKY---DKELITFIGISGIIIAQLGYLSISGNTPYgFVIAALA 362
Cdd:TIGR00881 240 PLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfngRRGPLAVFFMALIIVSLLVYWLNPAANPL-MDLICLF 318
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1391035794 363 LHGLSVGFFQSPNNALVMSTVDKKYLGIAGSVNSLARNI-AFVLGTSLATISLFF 416
Cdd:TIGR00881 319 ALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLgGILAGLPLGYLADGF 373
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
9-341 |
5.08e-03 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 39.14 E-value: 5.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 9 LISIGIFIFMSTLDGSIVNVALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFL 88
Cdd:cd17336 5 VVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGLGCFL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 89 aginlgWGLP-FLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFvsvgSIAGPAIGGLILQITSWNYIFW 167
Cdd:cd17336 85 ------LALPhFLFVGQFLLGIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAM----RVLGPALGFLLGSFLLRIYVDF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 168 INVPVGIiayflgshalpkekakgSVQEVDFIGsalmALTIVFLFLGInygqiagwsnpfvigAIILAVILFVLFirten 247
Cdd:cd17336 155 SRVPLGI-----------------TPDDPRWIG----AWWLGFLILGI---------------LLLIVSIPLFFF----- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 248 rksvplidlgifkSKLFSLSVLTAMLNFTAAMFVNILMPFFLQDYHGLSAGVAGLMMTA-YPVAMLISSPISGVLSDKYD 326
Cdd:cd17336 194 -------------PPIFILLLLAIVFESFAISGFSTFLPKYLETQFRLSASLASLLTGLiLVPGAALGILLGGLIIKKFK 260
|
330
....*....|....*...
gi 1391035794 327 ---KELITFIGISGIIIA 341
Cdd:cd17336 261 ltaRGLAKFVLILSLLSV 278
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
5-192 |
5.50e-03 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 39.10 E-value: 5.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 5 RILALiSIGIFIFMSTldgSIVNVA-LPTMSRELQVSLAQVTWVVTIYLIVISAVILIFgrlgdLLGKANVFRTGAIIFT 83
Cdd:PRK03545 10 RVVTL-ALAAFIFNTT---EFVPVGlLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPL-----MLLTSNVERRKLLIGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 84 IGSFLAGINL---GWGLPFLLFARIVQAVGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQIT 160
Cdd:PRK03545 81 FVLFIASHVLsalAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYL 160
|
170 180 190
....*....|....*....|....*....|..
gi 1391035794 161 SWNYIFWINVPVGIIAYFLGSHALPKEKAKGS 192
Cdd:PRK03545 161 GWRTTFLAIGGGALITLLLLIKLLPLLPSEHS 192
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
29-178 |
7.98e-03 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 38.38 E-value: 7.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 29 ALPTMSRELQVSLAQVTWVVTIYLIVISAVILIFGRLGDLLGKANVFRTGAIIFTIGSFLagINLGWGLPFLLFARIVQA 108
Cdd:PRK15402 35 GMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLA--ILLAQSIEQFTLLRFLQG 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391035794 109 VGGSMFMATSFGLVAQIFPPETRARAMAINSMFVSVGSIAGPAIGGLILQITSWNYIFWINVPVGIIAYF 178
Cdd:PRK15402 113 IGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFF 182
|
|
| |
