|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
1-640 |
0e+00 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 644.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 1 MRLFIAEKPAVANDIVKALGgNFTRHDGWFESDNAIVTNCFGHIIESQPPENYNPEYKAWKVETLPLrlFPV--KYQPVE 78
Cdd:PRK07726 1 MRLFIAEKPSVGRDIADVLK-PHKKGDGYIEGNGYIVTWAIGHLLELAEPEAYDERYKRWRLEDLPI--IPEkwKLVVKK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 79 SAAKQVKTILELIRrgDVTEIVHAGDPDDEGQLLVDEVLEYAGNTKPVKRVLINDNTLPAVKKALANLKDNRDFKGLYLK 158
Cdd:PRK07726 78 KTAKQFNVVKKLLK--QATEIVIATDADREGELIAREILDYCGVRKPIKRLWISSLTDKAIKRAFANLKPGKETIPLYYS 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 159 ALARSVADAVYGFSMTRAYTIPAKARGYQGILSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMTGVFQRGADvLRANWKP 238
Cdd:PRK07726 156 ALARSRADWLVGINMTRAYTLLGRKAGYNGVLSVGRVQTPTLALVVRRDEEIENFVPKPYWEVEAHLTPGER-FTAKWQP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 239 GEFAPLTDRKLLDKAWADGTAASLAGKPATVAAAATDDKKTAAPLPFNLVRLQQYMNKKFKMTAQKTLDITQQLREKYKA 318
Cdd:PRK07726 235 SEPYQDEEGRLLDRPLAEQVVARIQGQPAKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETLDIAQSLYETHKL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 319 ITYNRSDCSYLSDEQFSEAPQVIDALKSVFPQSL----DIDSARKSKAFNSAKVTAHTAIIPTASVPDVNALSTDERNVY 394
Cdd:PRK07726 315 ITYPRTDSRYLPEDMVATLPEVLNAISKVDPYLLlappVLDPSIRSRAWNDKKVTAHHAIIPTEQPPNLSKLSEDERKVY 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 395 QAIAQHYLVQFMPEKAYQEVSVAIQCGDESFCARARKTTDSGFEVFLGaeptdegeSEDNDDSAFELLCKIRTGETLTTK 474
Cdd:PRK07726 395 DLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWKALLG--------KKEEDEEKEQPLPVLAKGDELKVE 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 475 EVVVNEKKTTPPPLFTEASLLAALVRVADFVTDPTIkkllkdkdKDKKDEHGGIGTPATRAAILETLKKRNYITLEKGKL 554
Cdd:PRK07726 467 KGEVKEGQTQPPKRFTEGTLLSAMENIARFVQDKEL--------KKTLKETDGLGTEATRAGIIEKLFKRGYLEKKGKYI 538
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 555 IPTDTGYALIDALPGIAVNPDMTALWSEKQAAIENGDLTVEQFINELYGELTGMISDVDLGEMKIepaapagQFQRLDSP 634
Cdd:PRK07726 539 HATDKGKQLIDALPEELTSPDMTAKWEQALDQISEGQLSYQDFMQPLKQWLKQLVEQAKQSSEKY-------KFDNLTGP 611
|
....*..
gi 1445118078 635 -CPSCGK 640
Cdd:PRK07726 612 kCPDCGK 618
|
|
| topB |
TIGR01056 |
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ... |
1-654 |
4.45e-161 |
|
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273419 [Multi-domain] Cd Length: 660 Bit Score: 480.11 E-value: 4.45e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 1 MRLFIAEKPAVANDIVKALGGNfTRHDGWFESDNA-IVTNCFGHIIESQPPENYNPEYKAWKVETLPLRLFPVKYQPVES 79
Cdd:TIGR01056 1 MTLVLCEKPSQARDLATVLAKK-KKGNGYLEIGVGgFVTWAVGHLVELAEPEEYDEKYKNWRTYDLPLEPEDWQLVVSDK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 80 AAKQVKTILELIRRGDVTEIVHAGDPDDEGQLLVDEVLEYAGNTK--PVKRVLINDNTLPAVKKALANLKDNRDFKGLYL 157
Cdd:TIGR01056 80 TKKQFNVIKRILKENKVDEVVIATDPDREGELIAREILDYLKVTDkvTIKRLWISSLVDSSIRKAFKNLRPKSETEGLYK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 158 KALARSVADAVYGFSMTRAYTIPAKARGYQGILSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMTGVFQRGADVLRANWK 237
Cdd:TIGR01056 160 SGVARARADWLVGINLTRAFTKLGREAGNDGVLSVGRVQTPTLAMVVKRENEIKNFVGKPFYEVSATINKDEQEFTTEWQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 238 PGEFaplTDRKLLDKAWADGTAASLAGKPATVAAAATDDKKTAAPLPFNLVRLQQYMNKKFKMTAQKTLDITQQLREKYK 317
Cdd:TIGR01056 240 PYKD---EEERELHEFLAENVVTDLTQKPALVTDIEKERKKTSAPLFYDLSALQEDANKRFGISAKRTLDIAQKLYETHK 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 318 AITYNRSDCSYLSDEQFSEAPQVIDALKSVFP-----QSLDIDSarKSKAFNSAKVTAHTAIIPTASVPDVNALSTDERN 392
Cdd:TIGR01056 317 LITYPRTDSRYLPEDEKEMLLEVLDALKVITPallpiKKRDELT--NNRLWNDKKIEDHHAIIPTGNDFNLSDLSEEERN 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 393 VYQAIAQHYLVQFMPEKAYQEVSVAIQCGDESFCARARKTTDSGFEVFLGAEPTDEgESEDNDDSAFEllckirTGETLT 472
Cdd:TIGR01056 395 VYKLIAQNYLMQFMPKEEYETTTIEIAIGKLMFEAKGKILQDNGWKALLGKQEEDE-ETEDTTLPAFQ------KGDELD 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 473 TKEVVVNEKKTTPPPLFTEASLLAALVRVADFVTDPTIkkllkdkdKDKKDEHGGIGTPATRAAILETLKKRNYITLEKG 552
Cdd:TIGR01056 468 VETLELLEKQTKPPARYTEGTLLSAMTNPAAFVQDKGL--------KKTLKETKGLGTEATRADIIENLFKRGFIQKKKN 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 553 KLIPTDTGYALIDALPGIAVNPDMTALWSEKQAAIENGDLTVEQFINELYGELTGMISDvdlgemkiEPAAPAGQFQRLD 632
Cdd:TIGR01056 540 KIYITKNGKLLCLLLPELLTKPDLTAQWEQYLNGISAGEKDDDDFINTINEMIKQTINE--------EKKNPETIQKVAK 611
|
650 660
....*....|....*....|..
gi 1445118078 633 SPCPSCGKHIVIRPKGYFCTGC 654
Cdd:TIGR01056 612 EPVSCGGIAKCPAKDNGRLIDC 633
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
1-609 |
8.55e-147 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 439.15 E-value: 8.55e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 1 MRLFIAEKPAVANDIVKALGGNFtrhdgwfesdnaIVTNCFGHIIE-SQPPENYNPEYKawkvetlplrlFPVKYQPVES 79
Cdd:COG0550 1 KKLVIVESPAKAKTIAKYLGKDY------------VVTASVGHLRDlPKPELDVDVEND-----------FEPKYEVIPG 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 80 AAKQVKTILELIRRGDvtEIVHAGDPDDEGQLLVDEVLEYAGNTKPVKRVLINDNTLPAVKKALANLKDnrDFKGLYLKA 159
Cdd:COG0550 58 KKKQVKELKKLAKKAD--EVILATDPDREGEAIAWHLLELLGDKKPVKRVVFNEITKKAIKEAFKNPRD--IDMNLVDAQ 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 160 LARSVADAVYGFSMTRAYTipakaRGYQGILSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMTGVFQRGADVLRANWKPg 239
Cdd:COG0550 134 QARRILDRLVGYNLSPLLW-----KKVKRGLSAGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKTGGGEFTAKLVK- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 240 efapLTDRKLLDKAWADGTAASLAGKPATVAAAATDDKKTAAPLPFNLVRLQQYMNKKFKMTAQKTLDITQQLREKyKAI 319
Cdd:COG0550 208 ----IDGKKILDEEEAEAILAALKGKTFTVTSVEKKPKKRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRLYEV-GLI 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 320 TYNRSDCSYLSDEQFSEAPQVIDALKSvfPQSLdidsARKSKAFNSAK--VTAHTAIIPTASVPDVNALSTDERNVYQAI 397
Cdd:COG0550 283 TYMRTDSVRLSEDAVAAAREYIEALYG--KEYL----PEKPRVYKTSKnaQEAHEAIRPTGVTRTPESLSGDEFKLYDLI 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 398 AQHYLVQFMPEKAYQEVSVAIQCGDESFCARARKTTDSGFevfLGAEPTDEGESEDNDDsafELLCKIRTGETLTTKEVV 477
Cdd:COG0550 357 WKRFLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPGF---LKVYGEGKDDEEEEEE---KRLPPLKEGEKLKLKKIE 430
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 478 VNEKKTTPPPLFTEASLLAALvrvadfvtdptikkllkdkdkdkkdEHGGIGTPATRAAILETLKKRNYITLEKGKLIPT 557
Cdd:COG0550 431 PEQHFTKPPPRYTEASLVKAM-------------------------EELGIGRPSTYASIIETLQDRGYVEREGKRLVPT 485
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*
gi 1445118078 558 DTGYALIDALPGIA---VNPDMTALWSEKQAAIENGDLTVEQFINELYGELTGMI 609
Cdd:COG0550 486 ELGFIVIDLLEEHFpdlVDYEFTAKMEEKLDEIAEGKLDWKDVLEEFYKPFKELV 540
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
152-599 |
1.56e-111 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 343.46 E-value: 1.56e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 152 FKGLYLKALARSVADAVYGFSMTRAYTipaKARGYQGILSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMTGVFQRGADV 231
Cdd:pfam01131 3 DENLVDAQLARRELDWLIGFNLSRLLT---LKLKGNKLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATLKDGGGV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 232 -LRANWKPGEFapltdrklLDKAWADGTAASLAGKPATVAAAATDDKKTAAPLPFNLVRLQQYMNKKFKMTAQKTLDITQ 310
Cdd:pfam01131 80 fANAKWKRGRI--------FDKEEAEAILEKLKKGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 311 QLREKYKAITYNRSDCSYLSDEqfSEAPQVIDALKSVFPQSLD----IDSARKSKA-FNSAKVTAHTAIIPTASVPDVNA 385
Cdd:pfam01131 152 KLYEKHGLITYPRTDSTYLSDD--ATLKAILEYLTKNYGKYLPyaprLLKKTKGKLtVGNAKVTAHEAIRPTGDIPVLPE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 386 LSTDERNVYQAIAQHYLVQFMPEKAYQEVSVAIQCGDESFCARARKTTDSGF-EVFlgaeptdeGESEDNDDsafELLCK 464
Cdd:pfam01131 230 LSDDERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWlKVY--------PYEKKEDE---EELPE 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 465 IRTGETLTTKEVVVNEKKTTPPPLFTEASLLAALvrvadfvtdptikkllkdkdkdkkdEHGGIGTPATRAAILETLKKR 544
Cdd:pfam01131 299 LKEGEELKVTQVEVEEKKTKPPPRYTEASLIKAM-------------------------EKAGIGTPATRATIIETLLER 353
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1445118078 545 NYITLEKGKLIPTDTGYALIDALPGIA--VNPDMTALWSEKQAAIENGDLTVEQFIN 599
Cdd:pfam01131 354 GYVERKKKSLVPTELGKALVEALEKFPdlVDPELTAELEEKLDEIAEGKLDWKDVLA 410
|
|
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
154-609 |
1.64e-87 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 279.87 E-value: 1.64e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 154 GLYLKALARSVADAVYGFSMTRAYTipaKARGYQGILSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMtgvfqrgadvlr 233
Cdd:cd00186 2 NLVNAQLARRILDRLVGFNLSRLLT---KKLRRKGVLSAGRVQSPTLGLIVEREREIKAFVPEDYWEI------------ 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 234 anwkpgefapltdrklldkawADGTAASLAGKPatvaaaatddKKTAAPLPFNLVRLQQYMNKKFKMTAQKTLDITQQLR 313
Cdd:cd00186 67 ---------------------KEAVVVSVEKKE----------KKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLY 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 314 EKyKAITYNRSDCSYLSDEQFSEAPQVIDALKSVFPQSLDIDSARKSKAFNSAKVTAHTAIIPTASVPDVNA---LSTDE 390
Cdd:cd00186 116 EA-GLITYPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLGRRNPKRGKKEQGAHEAIRPTKVAPTPELeanLSEDE 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 391 RNVYQAIAQHYLVQFMPEKAYQEVSVAIQCGDESFCARARKTTDSGF-EVFlgaeptdeGESEDNDDsafELLCKIRTGE 469
Cdd:cd00186 195 FKLYELIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWlEVY--------PEEKDDEE---EEPPPLKEGD 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 470 TLTTKEVVVNEKKTTPPPLFTEASLLAALvrvadfvtdptikkllkdkdkdkkdEHGGIGTPATRAAILETLKKRNYITL 549
Cdd:cd00186 264 ELKLEEVELEEKETQPPPRYTEASLIKLM-------------------------EKRGIGRPSTYASIIETLLDRGYVEK 318
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1445118078 550 EKGKLIPTDTGYALIDALPGIA---VNPDMTALWSEKQAAIENGDLTVEQFINELYGELTGMI 609
Cdd:cd00186 319 EKKKLIPTELGFAVIELLEKHFpelVDPEFTAKLEEKLDEIAEGKKDYQEVLEEFYEEFKKIV 381
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
277-563 |
1.07e-59 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 201.71 E-value: 1.07e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 277 KKTAAPLPFNLVRLQQYMNKKFKMTAQKTLDITQQLREKyKAITYNRSDCSYLSDEQFSEAPQVIDALKSVFPQSL-DID 355
Cdd:smart00437 5 KKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEK-GLITYPRTDSTRLSEEAVLEARNYIQKLYGKEYLDLaVVL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 356 SARKSKAFNSAKVTAHTAIIPTASVP---DVNALSTDERNVYQAIAQHYLVQFMPEKAYQEVSVAIQCGDESFCARARKT 432
Cdd:smart00437 84 LKPRKPRKGKKAQGAHEAIRPTKPIFtpeLEKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKAKGKTL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 433 TDSGF-EVFlgaeptdeGESEDNDDSAFELLCKirtGETLTTKEVVVNEKKTTPPPLFTEASLLAALvrvadfvtdptik 511
Cdd:smart00437 164 LFDGWlKVY--------PEEKKEEEIELPTLKK---GDELKVEEVEVEEKETKPPARYTEASLIKLM------------- 219
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1445118078 512 kllkdkdkdkkdEHGGIGTPATRAAILETLKKRNYITLEKGKLIPTDTGYAL 563
Cdd:smart00437 220 ------------EKRGIGRPSTYASIIETLLDRGYVTKKKKKLIPTELGIAV 259
|
|
| Toprim_Crpt |
pfam13342 |
C-terminal repeat of topoisomerase; |
653-712 |
2.66e-17 |
|
C-terminal repeat of topoisomerase;
Pssm-ID: 463851 [Multi-domain] Cd Length: 60 Bit Score: 76.36 E-value: 2.66e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 653 GCEFKIWSEFSGKKITQAQAEKLVKSGKTDLIKGFKKKSGGTYDTVLVLEDKKTGKLGFP 712
Cdd:pfam13342 1 GCGFSIGKTIAGKKLSEEQVKELLTKGKTGLIKGFKSKKGKKFDAYLVLDDDEKVEFDFE 60
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
1-640 |
0e+00 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 644.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 1 MRLFIAEKPAVANDIVKALGgNFTRHDGWFESDNAIVTNCFGHIIESQPPENYNPEYKAWKVETLPLrlFPV--KYQPVE 78
Cdd:PRK07726 1 MRLFIAEKPSVGRDIADVLK-PHKKGDGYIEGNGYIVTWAIGHLLELAEPEAYDERYKRWRLEDLPI--IPEkwKLVVKK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 79 SAAKQVKTILELIRrgDVTEIVHAGDPDDEGQLLVDEVLEYAGNTKPVKRVLINDNTLPAVKKALANLKDNRDFKGLYLK 158
Cdd:PRK07726 78 KTAKQFNVVKKLLK--QATEIVIATDADREGELIAREILDYCGVRKPIKRLWISSLTDKAIKRAFANLKPGKETIPLYYS 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 159 ALARSVADAVYGFSMTRAYTIPAKARGYQGILSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMTGVFQRGADvLRANWKP 238
Cdd:PRK07726 156 ALARSRADWLVGINMTRAYTLLGRKAGYNGVLSVGRVQTPTLALVVRRDEEIENFVPKPYWEVEAHLTPGER-FTAKWQP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 239 GEFAPLTDRKLLDKAWADGTAASLAGKPATVAAAATDDKKTAAPLPFNLVRLQQYMNKKFKMTAQKTLDITQQLREKYKA 318
Cdd:PRK07726 235 SEPYQDEEGRLLDRPLAEQVVARIQGQPAKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETLDIAQSLYETHKL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 319 ITYNRSDCSYLSDEQFSEAPQVIDALKSVFPQSL----DIDSARKSKAFNSAKVTAHTAIIPTASVPDVNALSTDERNVY 394
Cdd:PRK07726 315 ITYPRTDSRYLPEDMVATLPEVLNAISKVDPYLLlappVLDPSIRSRAWNDKKVTAHHAIIPTEQPPNLSKLSEDERKVY 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 395 QAIAQHYLVQFMPEKAYQEVSVAIQCGDESFCARARKTTDSGFEVFLGaeptdegeSEDNDDSAFELLCKIRTGETLTTK 474
Cdd:PRK07726 395 DLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWKALLG--------KKEEDEEKEQPLPVLAKGDELKVE 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 475 EVVVNEKKTTPPPLFTEASLLAALVRVADFVTDPTIkkllkdkdKDKKDEHGGIGTPATRAAILETLKKRNYITLEKGKL 554
Cdd:PRK07726 467 KGEVKEGQTQPPKRFTEGTLLSAMENIARFVQDKEL--------KKTLKETDGLGTEATRAGIIEKLFKRGYLEKKGKYI 538
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 555 IPTDTGYALIDALPGIAVNPDMTALWSEKQAAIENGDLTVEQFINELYGELTGMISDVDLGEMKIepaapagQFQRLDSP 634
Cdd:PRK07726 539 HATDKGKQLIDALPEELTSPDMTAKWEQALDQISEGQLSYQDFMQPLKQWLKQLVEQAKQSSEKY-------KFDNLTGP 611
|
....*..
gi 1445118078 635 -CPSCGK 640
Cdd:PRK07726 612 kCPDCGK 618
|
|
| topB |
TIGR01056 |
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ... |
1-654 |
4.45e-161 |
|
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273419 [Multi-domain] Cd Length: 660 Bit Score: 480.11 E-value: 4.45e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 1 MRLFIAEKPAVANDIVKALGGNfTRHDGWFESDNA-IVTNCFGHIIESQPPENYNPEYKAWKVETLPLRLFPVKYQPVES 79
Cdd:TIGR01056 1 MTLVLCEKPSQARDLATVLAKK-KKGNGYLEIGVGgFVTWAVGHLVELAEPEEYDEKYKNWRTYDLPLEPEDWQLVVSDK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 80 AAKQVKTILELIRRGDVTEIVHAGDPDDEGQLLVDEVLEYAGNTK--PVKRVLINDNTLPAVKKALANLKDNRDFKGLYL 157
Cdd:TIGR01056 80 TKKQFNVIKRILKENKVDEVVIATDPDREGELIAREILDYLKVTDkvTIKRLWISSLVDSSIRKAFKNLRPKSETEGLYK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 158 KALARSVADAVYGFSMTRAYTIPAKARGYQGILSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMTGVFQRGADVLRANWK 237
Cdd:TIGR01056 160 SGVARARADWLVGINLTRAFTKLGREAGNDGVLSVGRVQTPTLAMVVKRENEIKNFVGKPFYEVSATINKDEQEFTTEWQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 238 PGEFaplTDRKLLDKAWADGTAASLAGKPATVAAAATDDKKTAAPLPFNLVRLQQYMNKKFKMTAQKTLDITQQLREKYK 317
Cdd:TIGR01056 240 PYKD---EEERELHEFLAENVVTDLTQKPALVTDIEKERKKTSAPLFYDLSALQEDANKRFGISAKRTLDIAQKLYETHK 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 318 AITYNRSDCSYLSDEQFSEAPQVIDALKSVFP-----QSLDIDSarKSKAFNSAKVTAHTAIIPTASVPDVNALSTDERN 392
Cdd:TIGR01056 317 LITYPRTDSRYLPEDEKEMLLEVLDALKVITPallpiKKRDELT--NNRLWNDKKIEDHHAIIPTGNDFNLSDLSEEERN 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 393 VYQAIAQHYLVQFMPEKAYQEVSVAIQCGDESFCARARKTTDSGFEVFLGAEPTDEgESEDNDDSAFEllckirTGETLT 472
Cdd:TIGR01056 395 VYKLIAQNYLMQFMPKEEYETTTIEIAIGKLMFEAKGKILQDNGWKALLGKQEEDE-ETEDTTLPAFQ------KGDELD 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 473 TKEVVVNEKKTTPPPLFTEASLLAALVRVADFVTDPTIkkllkdkdKDKKDEHGGIGTPATRAAILETLKKRNYITLEKG 552
Cdd:TIGR01056 468 VETLELLEKQTKPPARYTEGTLLSAMTNPAAFVQDKGL--------KKTLKETKGLGTEATRADIIENLFKRGFIQKKKN 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 553 KLIPTDTGYALIDALPGIAVNPDMTALWSEKQAAIENGDLTVEQFINELYGELTGMISDvdlgemkiEPAAPAGQFQRLD 632
Cdd:TIGR01056 540 KIYITKNGKLLCLLLPELLTKPDLTAQWEQYLNGISAGEKDDDDFINTINEMIKQTINE--------EKKNPETIQKVAK 611
|
650 660
....*....|....*....|..
gi 1445118078 633 SPCPSCGKHIVIRPKGYFCTGC 654
Cdd:TIGR01056 612 EPVSCGGIAKCPAKDNGRLIDC 633
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
1-609 |
8.55e-147 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 439.15 E-value: 8.55e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 1 MRLFIAEKPAVANDIVKALGGNFtrhdgwfesdnaIVTNCFGHIIE-SQPPENYNPEYKawkvetlplrlFPVKYQPVES 79
Cdd:COG0550 1 KKLVIVESPAKAKTIAKYLGKDY------------VVTASVGHLRDlPKPELDVDVEND-----------FEPKYEVIPG 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 80 AAKQVKTILELIRRGDvtEIVHAGDPDDEGQLLVDEVLEYAGNTKPVKRVLINDNTLPAVKKALANLKDnrDFKGLYLKA 159
Cdd:COG0550 58 KKKQVKELKKLAKKAD--EVILATDPDREGEAIAWHLLELLGDKKPVKRVVFNEITKKAIKEAFKNPRD--IDMNLVDAQ 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 160 LARSVADAVYGFSMTRAYTipakaRGYQGILSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMTGVFQRGADVLRANWKPg 239
Cdd:COG0550 134 QARRILDRLVGYNLSPLLW-----KKVKRGLSAGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKTGGGEFTAKLVK- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 240 efapLTDRKLLDKAWADGTAASLAGKPATVAAAATDDKKTAAPLPFNLVRLQQYMNKKFKMTAQKTLDITQQLREKyKAI 319
Cdd:COG0550 208 ----IDGKKILDEEEAEAILAALKGKTFTVTSVEKKPKKRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRLYEV-GLI 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 320 TYNRSDCSYLSDEQFSEAPQVIDALKSvfPQSLdidsARKSKAFNSAK--VTAHTAIIPTASVPDVNALSTDERNVYQAI 397
Cdd:COG0550 283 TYMRTDSVRLSEDAVAAAREYIEALYG--KEYL----PEKPRVYKTSKnaQEAHEAIRPTGVTRTPESLSGDEFKLYDLI 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 398 AQHYLVQFMPEKAYQEVSVAIQCGDESFCARARKTTDSGFevfLGAEPTDEGESEDNDDsafELLCKIRTGETLTTKEVV 477
Cdd:COG0550 357 WKRFLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPGF---LKVYGEGKDDEEEEEE---KRLPPLKEGEKLKLKKIE 430
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 478 VNEKKTTPPPLFTEASLLAALvrvadfvtdptikkllkdkdkdkkdEHGGIGTPATRAAILETLKKRNYITLEKGKLIPT 557
Cdd:COG0550 431 PEQHFTKPPPRYTEASLVKAM-------------------------EELGIGRPSTYASIIETLQDRGYVEREGKRLVPT 485
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*
gi 1445118078 558 DTGYALIDALPGIA---VNPDMTALWSEKQAAIENGDLTVEQFINELYGELTGMI 609
Cdd:COG0550 486 ELGFIVIDLLEEHFpdlVDYEFTAKMEEKLDEIAEGKLDWKDVLEEFYKPFKELV 540
|
|
| PRK08173 |
PRK08173 |
DNA topoisomerase III; Validated |
3-711 |
1.93e-116 |
|
DNA topoisomerase III; Validated
Pssm-ID: 236172 [Multi-domain] Cd Length: 862 Bit Score: 370.54 E-value: 1.93e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 3 LFIAEKPAVANDIVKALGGnFTRHDGWFESDNAIVTNCFGHIIESQPPENYNPEYKAWKVETLPL--RLFPVKyqPVESA 80
Cdd:PRK08173 5 LIIAEKPSVANDIARALGG-FTKHDEYFESDEYVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVipPHFDLN--PIAKT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 81 AKQVKTILELIRRGDVTEIVHAGDPDDEGQLLVDEVLEYAGNTKPVKRVLINDNTLPAVKKALANLKDNRDFKGLYLKAL 160
Cdd:PRK08173 82 ESRLKVLTKLIKRKDVTRLINACDAGREGELIFRLIAQHAKAKKPVKRLWLQSMTPQAIRDGFANLRSDEDMQPLADAAR 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 161 ARSVADAVYGFSMTRAYT-IPAKARGYQgILSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMTGVFQRGADVLRANW--- 236
Cdd:PRK08173 162 CRSEADWLVGINGTRAMTaFNSKGGGFF-LTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFVAAAGFYEGRWfdp 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 237 --KPGEFAP-LTDRKLLDKAWADGTAASLAGKPATVAAAATDDKKtAAPLPFNLVRLQQYMNKKFKMTAQKTLDITQQLR 313
Cdd:PRK08173 241 kfKKDEFDPeKRASRLWSEAAAEAIVAACRGKPGTVTEESKPSTQ-LSPLLFDLTSLQREANGRFGFSAKNTLGLAQALY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 314 EKYKAITYNRSDCSYLSDEQFSEAPQVIDALKSVFP------QSLDIDSARKSK-AFNSAKVTAHTAIIPTASVPdvNAL 386
Cdd:PRK08173 320 EKHKVLTYPRTDSRALPEDYLGTVKQTLEMLKESNNylphakQILDKGWVKPNKrIFDNSKISDHFAIIPTLQAP--KSL 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 387 STDERNVYQAIAQHYLVQFMPEKAYQEVSVAIQCGDESFCARARKTTDSGFEVFLGAEPTDEGESednddsafelLCKIR 466
Cdd:PRK08173 398 SEPEQKLYDLVVKRFLAVFFPAAEFLVTTRITEVAGHHFKTEGKVLVNPGWLAVYGKEAQGADAN----------LVPVQ 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 467 TGETLTTKEVVVNEKKTTPPPLFTEASLLAALVRVADFVTDPTIKKLLKDKdkdkkdehgGIGTPATRAAILETLKKRNY 546
Cdd:PRK08173 468 KGEKVKTDKIEAVALTTKPPARYNEATLLSAMEGAGKLVEDDELREAMAEK---------GLGTPATRAAIIEGLLGEKY 538
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 547 ITLEKGKLIPTDTGYALIDALPGIAVN----PDMTALWSEKQAAIENGDLTVEQFINELyGELTGMIsdVDLGEMKIEPA 622
Cdd:PRK08173 539 LVREGRELIPTAKAFQLMTLLRGLGVEeltsPELTGEWEYKLSQIERGKLSRDAFMQEI-AQMTQQI--VKRAKEYDSDT 615
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 623 APaGQFQRLDSPCPSCGKHIVIRPKGYFCTGCEFKIWSEFSGKKITQAQAEKLVKSGKTDLIKGFKKKSGGTYDTVLVL- 701
Cdd:PRK08173 616 IP-GDYATLQTPCPNCGGVVKENYRRFACTKCDFSISKIPGGRQFEIAEVEELLRKKEIGPLSGFRSKMGRPFSAILKLs 694
|
730
....*....|
gi 1445118078 702 EDKKTGKLGF 711
Cdd:PRK08173 695 DETKNYKLEF 704
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
152-599 |
1.56e-111 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 343.46 E-value: 1.56e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 152 FKGLYLKALARSVADAVYGFSMTRAYTipaKARGYQGILSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMTGVFQRGADV 231
Cdd:pfam01131 3 DENLVDAQLARRELDWLIGFNLSRLLT---LKLKGNKLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATLKDGGGV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 232 -LRANWKPGEFapltdrklLDKAWADGTAASLAGKPATVAAAATDDKKTAAPLPFNLVRLQQYMNKKFKMTAQKTLDITQ 310
Cdd:pfam01131 80 fANAKWKRGRI--------FDKEEAEAILEKLKKGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 311 QLREKYKAITYNRSDCSYLSDEqfSEAPQVIDALKSVFPQSLD----IDSARKSKA-FNSAKVTAHTAIIPTASVPDVNA 385
Cdd:pfam01131 152 KLYEKHGLITYPRTDSTYLSDD--ATLKAILEYLTKNYGKYLPyaprLLKKTKGKLtVGNAKVTAHEAIRPTGDIPVLPE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 386 LSTDERNVYQAIAQHYLVQFMPEKAYQEVSVAIQCGDESFCARARKTTDSGF-EVFlgaeptdeGESEDNDDsafELLCK 464
Cdd:pfam01131 230 LSDDERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWlKVY--------PYEKKEDE---EELPE 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 465 IRTGETLTTKEVVVNEKKTTPPPLFTEASLLAALvrvadfvtdptikkllkdkdkdkkdEHGGIGTPATRAAILETLKKR 544
Cdd:pfam01131 299 LKEGEELKVTQVEVEEKKTKPPPRYTEASLIKAM-------------------------EKAGIGTPATRATIIETLLER 353
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1445118078 545 NYITLEKGKLIPTDTGYALIDALPGIA--VNPDMTALWSEKQAAIENGDLTVEQFIN 599
Cdd:pfam01131 354 GYVERKKKSLVPTELGKALVEALEKFPdlVDPELTAELEEKLDEIAEGKLDWKDVLA 410
|
|
| PRK14724 |
PRK14724 |
DNA topoisomerase III; Provisional |
3-711 |
7.98e-100 |
|
DNA topoisomerase III; Provisional
Pssm-ID: 237803 [Multi-domain] Cd Length: 987 Bit Score: 329.22 E-value: 7.98e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 3 LFIAEKPAVANDIVKAL---GGNFTRHDGWFESDNAIVTNCFGHIIESQPPENYNPEYKAWKVETLPLRLFPVKYQPVES 79
Cdd:PRK14724 4 LVIAEKPSVAQDIVRALtpvAGKFEKHDEHFESDSYVVTSAVGHLVEIQAPEEFDVKRGKWSFANLPVIPPYFDLKPVDK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 80 AAKQVKTILELIRRGDVTEIVHAGDPDDEGQLLVDEVLEYAGNT-----KPVKRVLINDNTLPAVKKALANLKDNRDFKG 154
Cdd:PRK14724 84 TKTRLNAVVKLAKRKDVTELVNACDAGREGELIFRLIEQYAGGAkgglgKPVKRLWLQSMTPQAIRDGFDNLRSDAQMQG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 155 LYLKALARSVADAVYGFSMTRAYTIPAKARGYQGILSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMTGVFQRGADVLRA 234
Cdd:PRK14724 164 LASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEIHAGFHAEAGEYLG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 235 NW------KPGEFAPLTDRKLLDKAWADGTAASLAGKPATVAAAATDDKKtAAPLPFNLVRLQQYMNKKFKMTAQKTLDI 308
Cdd:PRK14724 244 KWfdpqwkKASDDPEARADRVWSEREARAIADAVRGKAATVTEESKPTTQ-ASPLLFDLTSLQREANGKFGFSAKTTLAL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 309 TQQLREKYKAITYNRSDCSYLSDEQFSEAPQVIDAL-----KSVFP---QSLDIDSARKSK-AFNSAKVTAHTAIIPTAS 379
Cdd:PRK14724 323 AQSLYERHKALTYPRTDSRALPEDYLPVAKQTFEMLatsgmRHLAPfaqQALDGNYVRPSKrIFDNSKVSDHFAIIPTTQ 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 380 VPdvNALSTDERNVYQAIAQHYLVQFMPEKAYQEVSVAIQCGDESFCARARKTTDSGFEVFLGAEPTDEGESEDNDDSAf 459
Cdd:PRK14724 403 AP--SGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISQVVGHSFKTEGKVLVKPGWLAIYGKEAANEVEDAKDGDKG- 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 460 ELLCKIRTGETLTTKEVVVNEKKTTPPPLFTEASLLAALVRVADFVTDPTIkkllkdkdkDKKDEHGGIGTPATRAAILE 539
Cdd:PRK14724 480 QPLVPVKPGEMVRTEFAEAKGLKTKPPARYSEATLLGAMESAGKQIDDDEL---------REAMQEKGLGTPATRAAIIE 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 540 TLKKRNYITLEKGKLIPTDTGYALIDALPGIAVN----PDMTALWSEKQAAIENGDLTVEQFINELYGELTGMISDVDLG 615
Cdd:PRK14724 551 GLLTEKYMLREGRELIPTAKAFQLMTLLRGLGVEelsrAELTGEWEYKLAQMEKGQLSREAFMQQIAAMTEKLVKKAKEY 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 616 EMKIEPaapaGQFQRLDSPCPSCGKHIVIRPKGYFCTG-------CEFKIWSEFSGKKITQAQAEKLVKSGKTDLIKGFK 688
Cdd:PRK14724 631 DRDTIP----GDYATLSTPCPNCGGVVKENYRRYACTGangagegCGFSFTKSPAGRTFETAEAEQLLRDRRIGPLEGFR 706
|
730 740
....*....|....*....|....*.
gi 1445118078 689 KKSGGTYDTVLVL---EDKKTGKLGF 711
Cdd:PRK14724 707 SKAGWPFTAEVVIkrdEEAKNYKLEF 732
|
|
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
154-609 |
1.64e-87 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 279.87 E-value: 1.64e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 154 GLYLKALARSVADAVYGFSMTRAYTipaKARGYQGILSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMtgvfqrgadvlr 233
Cdd:cd00186 2 NLVNAQLARRILDRLVGFNLSRLLT---KKLRRKGVLSAGRVQSPTLGLIVEREREIKAFVPEDYWEI------------ 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 234 anwkpgefapltdrklldkawADGTAASLAGKPatvaaaatddKKTAAPLPFNLVRLQQYMNKKFKMTAQKTLDITQQLR 313
Cdd:cd00186 67 ---------------------KEAVVVSVEKKE----------KKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLY 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 314 EKyKAITYNRSDCSYLSDEQFSEAPQVIDALKSVFPQSLDIDSARKSKAFNSAKVTAHTAIIPTASVPDVNA---LSTDE 390
Cdd:cd00186 116 EA-GLITYPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLGRRNPKRGKKEQGAHEAIRPTKVAPTPELeanLSEDE 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 391 RNVYQAIAQHYLVQFMPEKAYQEVSVAIQCGDESFCARARKTTDSGF-EVFlgaeptdeGESEDNDDsafELLCKIRTGE 469
Cdd:cd00186 195 FKLYELIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWlEVY--------PEEKDDEE---EEPPPLKEGD 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 470 TLTTKEVVVNEKKTTPPPLFTEASLLAALvrvadfvtdptikkllkdkdkdkkdEHGGIGTPATRAAILETLKKRNYITL 549
Cdd:cd00186 264 ELKLEEVELEEKETQPPPRYTEASLIKLM-------------------------EKRGIGRPSTYASIIETLLDRGYVEK 318
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1445118078 550 EKGKLIPTDTGYALIDALPGIA---VNPDMTALWSEKQAAIENGDLTVEQFINELYGELTGMI 609
Cdd:cd00186 319 EKKKLIPTELGFAVIELLEKHFpelVDPEFTAKLEEKLDEIAEGKKDYQEVLEEFYEEFKKIV 381
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
1-657 |
3.77e-69 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 242.21 E-value: 3.77e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 1 MRLFIAEKPAVANDIVKAL-GGNFT--RHDGW----FESDNA--IVTNCFGHIIESQPPENYNpEYKAWKVETLPlRLFP 71
Cdd:PRK07219 1 TELIIAEKNNAARRIADILsGGKAKkkRVNGVpyyeFERKGEkwIVIGLSGHIVTVDFPEEYG-DWRDVDPAELI-DADP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 72 VKYQPVESAAKQVKTIlelirRGDVTEIVHAGDPDDEGQLLVDEV---LEYAGNtKPVKRVLINDNTLPAVKKALANLkD 148
Cdd:PRK07219 79 VKKITKQNYINALKKL-----AKDADEIIIATDYDREGELIGKEAyhiLREVCQ-VPVKRARFSSLTKKEIRKAFENP-D 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 149 NRDFkGLYLKALARSVADAVYGFSMTRAYTIPAKARGYQGILSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMTGVFQRG 228
Cdd:PRK07219 152 EIDF-NLADAGEARQIIDLYWGAALTRFLSLSVRQLGRWDFLSVGRVQTPTLAFIVDREREIRAFDPEDYWKIEALLDKE 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 229 ADVLRANWKPGEFApltdRKLLDKAWADGTAASLAG-KPATVAAAATDDKKTAAPLPFNLVRLQQYMNKKFKMTAQKTLD 307
Cdd:PRK07219 231 AQYFYRDLIGGHEA----EKFWDEEEAEEIYEKLKGaKEATVSSVKKRERTISPPAPFNTTEFLREASKIFGISPKRAME 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 308 ITQQLREK-YkaITYNRSDCS-YLSDEQFSEapqVIDAL--KSVF-PQSLDIDSARKSKAFNSAK-VTAHTAIIPTaSVP 381
Cdd:PRK07219 307 IAEKLYTAgY--ISYPRTDNTvYPDDLDPKE---LLKKLskKKEYgPYAESILEQENIKPTEGKKeTTDHPPIHPV-DVP 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 382 DVNALSTDERNVYQAIAQHYLVQFMPEKAYQEVSVAIQCGDESFCARARKTTDSGFEVFLGAEPTDEgesednddsafEL 461
Cdd:PRK07219 381 KREELSDDEWKVYELIVRRFLATLADPAEWEYLKVELDVNGEIFKASGSRLVEEGWHEVYPYEKFDE-----------KE 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 462 LCKIRTGETLTTKEVVVNEKKTTPPPLFTEASLLAALvrvadfvtdptikkllkdkdkdkkdEHGGIGTPATRAAILETL 541
Cdd:PRK07219 450 LPDLEEGEKLKVNKIEIEAKETQPPKRYTQSSLIKEM-------------------------EKRGLGTKATRHDIIEKL 504
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 542 KKRNYITlEKGKLIPTDTGYALIDALPGIA---VNPDMTALWSEKQAAIENGDLTVEQFINELYGELTGMISDVDLG--E 616
Cdd:PRK07219 505 YKRGYVI-EGDPPRPTDLGIAVIEALEKYApeiVSEEMTAQLEADMQAIEDGKKKKEDVTEESREMLKEILSELKEKrkE 583
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|...
gi 1445118078 617 MKIEPA----APAGQFQRLdSPCPSCGKHIVI---RPKGYF--CTG---CEFK 657
Cdd:PRK07219 584 IGDHLAgslkAENRSLKTI-GKCPECGGDLIIirtDKGSRFvgCSGypdCRNT 635
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
277-563 |
1.07e-59 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 201.71 E-value: 1.07e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 277 KKTAAPLPFNLVRLQQYMNKKFKMTAQKTLDITQQLREKyKAITYNRSDCSYLSDEQFSEAPQVIDALKSVFPQSL-DID 355
Cdd:smart00437 5 KKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEK-GLITYPRTDSTRLSEEAVLEARNYIQKLYGKEYLDLaVVL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 356 SARKSKAFNSAKVTAHTAIIPTASVP---DVNALSTDERNVYQAIAQHYLVQFMPEKAYQEVSVAIQCGDESFCARARKT 432
Cdd:smart00437 84 LKPRKPRKGKKAQGAHEAIRPTKPIFtpeLEKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKAKGKTL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 433 TDSGF-EVFlgaeptdeGESEDNDDSAFELLCKirtGETLTTKEVVVNEKKTTPPPLFTEASLLAALvrvadfvtdptik 511
Cdd:smart00437 164 LFDGWlKVY--------PEEKKEEEIELPTLKK---GDELKVEEVEVEEKETKPPARYTEASLIKLM------------- 219
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1445118078 512 kllkdkdkdkkdEHGGIGTPATRAAILETLKKRNYITLEKGKLIPTDTGYAL 563
Cdd:smart00437 220 ------------EKRGIGRPSTYASIIETLLDRGYVTKKKKKLIPTELGIAV 259
|
|
| PRK06599 |
PRK06599 |
DNA topoisomerase I; Validated |
1-645 |
2.36e-54 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235840 [Multi-domain] Cd Length: 675 Bit Score: 198.54 E-value: 2.36e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 1 MRLFIAEKPAVANDIVKALGGNFTrhdgwfesdnaiVTNCFGHIIE------SQPPENYnpeykawkvetlplrlFPVKY 74
Cdd:PRK06599 3 KKLVIVESPAKAKTIKKYLGKDYK------------VLASFGHVRDlpkkkgGVDPDND----------------FAPKY 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 75 QPVESAAKQVKTILELIRRGDvtEIVHAGDPDDEGQLL---VDEVLEYAGNT-KPVKRVLINDNTLPAVKKALANLKD-N 149
Cdd:PRK06599 55 EIIEGKEKVVDALKKAAKKAD--AVYLATDPDREGEAIawhIAEVLKEAKLKdKNVKRVVFNEITKKAVQEAIENPRDiD 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 150 RDfkgLYLKALARSVADAVYGFSMTraytiPAKARGYQGILSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMTGVFQRGA 229
Cdd:PRK06599 133 MD---LVDAQQARRALDYLVGFKLS-----PLLWKKVRRGLSAGRVQSVALRLICEREDEIEAFIPQEYWTIEADLATSN 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 230 D-VLRANW------KPGEFapltdrKLLDKAWADGTAASLAGKPATVAAAATDDKKTAAPLPFNLVRLQQYMNKKFKMTA 302
Cdd:PRK06599 205 GePFTAKLvevngkKLEKF------SITNEEQAKALVKALEGQAYTVDKIEKKERKRNPPPPFITSTLQQEASRKLGFSA 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 303 QKTLDITQQLrekYKA----------ITYNRSDCSYLSDEQFSEAPQVIDAL--KSVFPqsldiDSARKSKafNSAKVT- 369
Cdd:PRK06599 279 KKTMRIAQKL---YEGidlgegtvglITYMRTDSVRLSNEALDEARKYITKKygKEYLP-----AKPRVYK--KKSKNAq 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 370 -AHTAIIPTAS--VPD--VNALSTDERNVYQAIAQHYLVQFMPEKAYQEVSVAIQCGDESFCARArkttdSG----FEVF 440
Cdd:PRK06599 349 eAHEAIRPTSInrTPEslKPYLTPDQFKLYELIWKRTVASQMAPAILDQTSVDIASENGKYVFRA-----TGsvilFPGF 423
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 441 LGAEPTDEGESEDNDDSafeLLCKIRTGETLTTKEVVVNEKKTTPPPLFTEASLLAALvrvadfvtdptikkllkdkdkd 520
Cdd:PRK06599 424 LKVYGESKDDEEEDDEK---LLPPLKEGEKLKLDELLPEQHFTEPPPRYSEASLVKKL---------------------- 478
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 521 kkdEHGGIGTPATRAAILETLKKRNYITLEKGKLIPTDTGYA----LIDALPGIaVNPDMTALWSEKQAAIENGDLTVEQ 596
Cdd:PRK06599 479 ---EEYGIGRPSTYASIISTLQDREYVELEKKRFIPTDLGRIvndfLVEHFPKY-VDYDFTAGLEDELDEIAEGKKDWKP 554
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|
gi 1445118078 597 FINELYGELTGMISDVDlGEMKIEPAAPagqfQRLDSPCPSC-GKHIVIR 645
Cdd:PRK06599 555 VLREFWEPFISNLEKVE-EDVRTEKVTQ----EETDETCPKCgGGPLVLK 599
|
|
| TOPRIM_TopoIA_TopoIII |
cd03362 |
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type ... |
1-146 |
1.80e-48 |
|
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173782 [Multi-domain] Cd Length: 151 Bit Score: 167.41 E-value: 1.80e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 1 MRLFIAEKPAVANDIVKALGGNFTR------HDGWFESDNAIVTNCFGHIIESQPPENYNPEYKAWKVETlPLRLFPVKY 74
Cdd:cd03362 1 MVLIIAEKPSVAKAIAKILGGGSKKkgkgryYEFYGEGGGYVVTWASGHLLELDFPEEYDPWDKVWPLED-PLFPAPFKL 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1445118078 75 QPVESAAKQVKTILELIRRGDvtEIVHAGDPDDEGQLLVDEVLEYAGN--TKPVKRVLINDNTLPAVKKALANL 146
Cdd:cd03362 80 KVDKGKKKQFKVLKKLAKRAD--EIVIATDADREGELIGREILEYAKCvkRKPVKRAWFSSLTPKAIRRAFKNL 151
|
|
| PRK08780 |
PRK08780 |
DNA topoisomerase I; Provisional |
3-563 |
2.46e-44 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 181555 [Multi-domain] Cd Length: 780 Bit Score: 170.71 E-value: 2.46e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 3 LFIAEKPAVANDIVKALGGNFTrhdgwfesdnaiVTNCFGHIIESQPPEN-YNPEYKawkvetlplrlFPVKYQPVESAA 81
Cdd:PRK08780 5 LVIVESPAKAKTINKYLGKDFT------------VLASYGHVRDLVPKEGaVDPENG-----------FAMRYDLIDKNE 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 82 KQVKTILELIRRGDvtEIVHAGDPDDEGQLL---VDEVLEYAG--NTKPVKRVLINDNTLPAVKKALANlkdNRDFKGLY 156
Cdd:PRK08780 62 KHVEAIAKAAKSAD--DLYLATDPDREGEAIswhLAEILKERGllKDKPMQRVVFTEITPRAIKEAMAK---PRDIASDL 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 157 LKAL-ARSVADAVYGFSMTraytiPAKARGYQGILSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMtgvfqrGADVLRAN 235
Cdd:PRK08780 137 VDAQqARRALDYLVGFNLS-----PLLWRKIQRGLSAGRVQSPALRMIVEREEEIEAFIAREYWSI------EADCAHPS 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 236 WK-PGEFAPLTDRKLLDKAWADGTAASLA---------GKPATVAAAATDDKKTAAPlPFNLVRLQQYMNKKFKMTAQKT 305
Cdd:PRK08780 206 QPfNAKLIKLDGQKFEQFTITDGDTAEAArlriqqaaqGTLHVTDVESKERKRNPAP-PFTTSTLQQEASRKLGFTTRRT 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 306 LDITQQLREKYKA--------ITYNRSDCSYLSDEQFSEAPQVI--DALKSVFPqsldiDSAR--KSKAFNSAKvtAHTA 373
Cdd:PRK08780 285 MQVAQKLYEGVDLgdegsvglITYMRTDSVNLSQDALAEIRDVIarDYGTASLP-----DQPNtyKTKSKNAQE--AHEA 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 374 IIPTAS--VPDVNA--LSTDERNVYQAIAQHYLVQFMPEKAYQEVSVAIQCGDE-SFCARARKTTDSGFeVFLGAEPTDE 448
Cdd:PRK08780 358 VRPTSAlrTPAQVArfLSDDQRRLYELIWKRAVACQMIPATLNTVSVDLAAGSEhVFRATGSTVVVPGF-LAVYEEGKDD 436
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 449 GESEDNDDSAFelLCKIRTGETLTTKEVVVNEKKTTPPPLFTEASLLAALvrvadfvtdptikkllkdkdkdkkdEHGGI 528
Cdd:PRK08780 437 KSAEDEDEGRK--LPPMKEGDNVPLERIRAEQHFTEPPPRYTEASLVKAL-------------------------EEYGI 489
|
570 580 590
....*....|....*....|....*....|....*
gi 1445118078 529 GTPATRAAILETLKKRNYITLEKGKLIPTDTGYAL 563
Cdd:PRK08780 490 GRPSTYASIISTLQFRKYVEMEGRRFRPTDVGRAV 524
|
|
| PRK07561 |
PRK07561 |
DNA topoisomerase I subunit omega; Validated |
1-645 |
5.81e-44 |
|
DNA topoisomerase I subunit omega; Validated
Pssm-ID: 236048 [Multi-domain] Cd Length: 859 Bit Score: 169.97 E-value: 5.81e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 1 MRLFIAEKPAVANDIVKALGGNFtrhdgwfesdnaIVTNCFGHIiESQPP--ENYNPEYKAWKVETL---PLRLFPVKYQ 75
Cdd:PRK07561 2 KSLVIVESPAKAKTINKYLGSDY------------VVKASVGHI-RDLPTsaSSVPAKEKGALWARMgvdPDHDFEALYE 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 76 PVESAAKQVKTILELIRrgDVTEIVHAGDPDDEGQ-----LLvdEVLEyaGNTKPVKRVLINDNTLPAVKKALANLKD-N 149
Cdd:PRK07561 69 VLPGKEKVVSELKKAAK--DADELYLATDPDREGEaiawhLL--EVLG--GDDVPVKRVVFNEITKNAIQEAFENPRElD 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 150 RDFKGLYLkalARSVADAVYGfsmtraYTI-P---AK-ARGyqgiLSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMTGV 224
Cdd:PRK07561 143 INLVNAQQ---ARRFLDRLVG------YMVsPllwKKiARG----LSAGRVQSVAVRLIVEREREIEAFVPEEYWDIHAD 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 225 FQ--RG----ADVLRANWKPgeFAPLTdrkLLDKAWADGTAASLAGKPATVAAAATDDKKTAAPLPFNLVRLQQYMNKKF 298
Cdd:PRK07561 210 LTtpRGdafeARLTHLDGKK--FAPVD---LLNEAQAEAAVAALEGARYSVASVEDKPTTRKPSAPFTTSTLQQEASRKL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 299 KMTAQKTLDITQQLrekYKA--ITYNRSDCSYLSDEQFSEAPQVIDAL--KSVFPqsldiDSAR--KSKAFNSAKvtAHT 372
Cdd:PRK07561 285 GFSVKKTMRIAQRL---YEAgyITYMRTDSTNLSQEAINAARGYIGDNygKKYLP-----EKPRqySSKAKNAQE--AHE 354
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 373 AIIPT---ASVPDVNALSTDERNVYQAIAQhylvQF----MPEKAYQEVSVAIQCGDESFCARARKTTdsgFEVFLGAEP 445
Cdd:PRK07561 355 AIRPSdvfRTPDQLKGLEGDAQRLYELIWK----RFvasqMAPARYDSTTVTIAAGDAELRATGRVLR---FDGFLKVYV 427
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 446 TDEGESEDNDDSafeLLCKIRTGETLTTKEVVVNEKKTTPPPLFTEASLLAALvrvadfvtdptikkllkdkdkdkkdEH 525
Cdd:PRK07561 428 EGRDDALDDEDR---RLPALKVGDALTLEKLDPTQHFTKPPARYSEASLVKEL-------------------------EK 479
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 526 GGIGTPATRAAILETLKKRNYITLEKGKLIPTDTGYALIDAL----PGIaVNPDMTALWSEKQAAIENGDLTVEQFINEL 601
Cdd:PRK07561 480 LGIGRPSTYASIISTIQDRGYVRLENRRFYPEKMGRIVTDRLeeffPRL-VDYDFTARMEEELDDIANGEADWKPVLDDF 558
|
650 660 670 680
....*....|....*....|....*....|....*....|....*.
gi 1445118078 602 YGELTGMISDV-DLGEMK-IEPaapaGQFQRLDSPCPSCGKHIVIR 645
Cdd:PRK07561 559 YKDFSQQLEKAeELREEGgMRP----NQMVITDRDCPTCGRGMGIR 600
|
|
| PRK07220 |
PRK07220 |
DNA topoisomerase I; Validated |
1-655 |
4.61e-43 |
|
DNA topoisomerase I; Validated
Pssm-ID: 180892 [Multi-domain] Cd Length: 740 Bit Score: 166.47 E-value: 4.61e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 1 MRLFIAEKPAVANDIVKALGG---NFTRHDG------WFESDNAIVTNCFGHIIESQPPENYNpeykAW-KVETLPLRLF 70
Cdd:PRK07220 1 MHLIITEKNIAARRIAQILAPkkpKKTRVSGvdvyryEDNGDDTVVVGLSGHIVNIDFPKEYN----NWqKVDARDLIDA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 71 PVKYQPVEsaAKQVKTILELIRRGDVTEIvhAGDPDDEGQLLVDEVLEYAGNTKP---VKRVLINDNTLPAVKKALANLK 147
Cdd:PRK07220 77 EIITTPTQ--KKIVTALKKLGKEADRVTI--ATDYDREGELIGVEALNIIKKVNPdikFDRVRYSAITKKEIERAFSNPV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 148 dNRDFKgLYLKALARSVADAVYGFSMTRAYTIPAKARGYQgILSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMTGVFQR 227
Cdd:PRK07220 153 -EVDFN-LADAGHSRQVIDLVWGAALTRYISLAAGRLGKM-FLSVGRVQSPTLALIVDREKEREAFVPTPYWEIYATLEN 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 228 GADVLRANWKPGEFapltdrklLDKAWADGTAASLaGKPATVAAAATDDKKTAAPLPFNLVRLQQYMNkKFKMTAQKTLD 307
Cdd:PRK07220 230 NGETFVAQHSTRRF--------WEKEEADRVFEKL-GKTAEVTEVEKGTKTDKPPTPFNTTEFISAAN-SIGFSAANAMR 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 308 ITQQL-REKYkaITYNRSDCSYLSD--------EQFSEAPQVIDALKSVFPQSLDIDSARKSkafnsakVTAHTAIIPTa 378
Cdd:PRK07220 300 IAESLyTNGY--ISYPRTDNTVYPEsldlreqiEIFAEGPFGEYAQKLLEKGELVPTRGKKE-------TTDHPPIYPA- 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 379 SVPDVNALSTDERNVYQAIAQHYLVQFMPEKAYQEVSVAIQCGDESFCARARKTTDSGFEVFLgaeptDEGESEDnddsa 458
Cdd:PRK07220 370 SLAKKSELKEDEWKVYELVVRRFFATFAGPAEWETMKLRFDIGGEEFRANGSRLTEPGWRWYY-----PYNAPED----- 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 459 fELLCKIRTGETLTTKEVVVNEKKTTPPPLFTEASLLAALvrvadfvtdptikkllkdkdkdkkdEHGGIGTPATRAAIL 538
Cdd:PRK07220 440 -RLLPELSEGEELKVKKKEMLDKETQPPGRYGQGRLIKLM-------------------------EDLGLGTKATRHEII 493
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 539 ETLKKRNYItlEKGKLIPTDTGYALIDAL----PGIAvNPDMTALWSEKQAAIENGDLTVEQFINELYGELTGMISDVDL 614
Cdd:PRK07220 494 SKLYSRAYI--HGNPIQPTNTAFAVVDALekyaPTIT-KPDMTSRLEEDMDKIAEGKIKEDAVLEESREMLEQVFDELDK 570
|
650 660 670 680
....*....|....*....|....*....|....*....|....
gi 1445118078 615 GEMKIEPAAPAG-QFQRLDSPCPSCGKHIVIR--PKGYFCTGCE 655
Cdd:PRK07220 571 NREKIRESLREGlREDKIIGKCPLCGSDLMVRrsKRGSRFIGCE 614
|
|
| TOPRIM_TopoIA |
cd01028 |
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
1-146 |
5.19e-43 |
|
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli topisomerases I and III, eukaryotic topoisomerase III and, ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA. These enzymes cleave one strand of the DNA duplex, covalently link to the 5' phosphoryl end of the DNA break and allow the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173778 [Multi-domain] Cd Length: 142 Bit Score: 151.99 E-value: 5.19e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 1 MRLFIAEKPAVANDIVKALGGNFTRHDGWFESDNAIVTNCFGHIIESQPPENYNPEYKAWKVEtlpLRLFPVKYQPVESA 80
Cdd:cd01028 1 KVLIIAEKPSKAKTIAKILGKGSKKKGFYGEGGGYVVTASVGHLLELPFPEEYVDWDKDWPLE---LFPFEPKYVVIPDK 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1445118078 81 AKQVKTILELIRRGDvtEIVHAGDPDDEGQLLVDEVLEYAGN-TKPVKRVLINDNTLPAVKKALANL 146
Cdd:cd01028 78 KKQLKALKKLAKKAD--EIVLATDPDREGELIAWEILEVLKCdNKPVKRAWFSEITPKAIREAFKNL 142
|
|
| PRK05776 |
PRK05776 |
DNA topoisomerase I; Provisional |
3-619 |
2.91e-41 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 235602 [Multi-domain] Cd Length: 670 Bit Score: 160.54 E-value: 2.91e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 3 LFIAEKPAVANDIVKALGGNFTR------------HDGwfesDNAIVTNCFGHIIESQPPENYNPEYKA-WKvetlPLrl 69
Cdd:PRK05776 4 LVIAEKPKAARKIAEALSEKPIRcriygvpywivkRDG----KKIVVAPAAGHLFGLHTKSKGFPVFDYeWK----PL-- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 70 fpvkYQpVESAAKQVKTILELIRR--GDVTEIVHAGDPDDEGQLLVDEVLEYAGNTKPVKRVLINDNTLPAVKKALANLK 147
Cdd:PRK05776 74 ----YE-IDKGSKYTKKYYELLSSlsKYADEFINACDYDIEGSVIGYLIIKYLGDPKKAKRMKFSALTKSDIRRAFRNLE 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 148 dNRDFkGLYLKALARSVADAVYGFSMTRAYTIPAK-ARGYQGILSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMTGVFQ 226
Cdd:PRK05776 149 -TLDY-EMINAGIARHELDWLWGINVSRALMSSVRdASGKRVILSAGRVQSPTLKYVVEREIERNLFVPLPYFSVSIIIE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 227 RGADVLRANWKPGEFAPLTD-RKLLDKAWADGTAAslagkpatVAAAATDDKKTAAPLPFNLVRLQQYMNKKFKMTAQKT 305
Cdd:PRK05776 227 KNGYEFTLKYENKKFETKEEaKEILEEIKKTGYLK--------VTKVEVKIEILEPPPPFNLGDLQVEAARIYGFSPYKT 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 306 LDITQQLREKyKAITYNRSDCSYLsdeqfseaPQVIDaLKSVFpQSLDIDSARKSKAFNSAKVT--------------AH 371
Cdd:PRK05776 299 QSIAEDLYLD-GLISYPRTNSQKL--------PPTLN-IRNIL-KGLSRSPQYRPLVNLLLKETkgvlkpvqgpkddpAH 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 372 TAIIPTASVPdvNALSTDERNVYQAIAQHYLVQFMPEKAYQEVSVAIQCGDE--SFCARARKTTDSGFEVFLGAEPTDEG 449
Cdd:PRK05776 368 PAIYPTGEPP--KNLSKDEFKLYDLIVRRFLASFAAPAVLSNTIVTLRVPGFplVFSASGQRIEERGWLKYYPFHKFDEE 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 450 EsednddsafelLCKIRTGETLTTKEVVVNEKKTTPPPLFTEASLLAALvrvadfvtdptikkllkdkdkdkkdEHGGIG 529
Cdd:PRK05776 446 E-----------LPLLKKGERVKIVDVKVRKSYTKPPSRYSKASLLKWM-------------------------ESVGIG 489
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 530 TPATRAAILETLKKRNYITLEKGKLIPTDTGYALIDAL----PGIaVNPDMTALWSEKQAAIENGDLTVEQFINELYGEL 605
Cdd:PRK05776 490 TEATRARIIETLFKRGYLTSNGKYIEVTPLGFGVAEVLekyfPDI-VSVELTRDFEEKLEMIRTGKATREEVIEEAKETL 568
|
650
....*....|....
gi 1445118078 606 TGMISDVDLGEMKI 619
Cdd:PRK05776 569 NKLLEEFKKNKDEI 582
|
|
| PRK14973 |
PRK14973 |
DNA topoisomerase I; Provisional |
1-658 |
1.08e-38 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 184936 [Multi-domain] Cd Length: 936 Bit Score: 154.23 E-value: 1.08e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 1 MRLFIAEKPAVANDIVKALGGN---FTRHDG---WFESDNAIVTNCFGHIIESqppeNYNPEYKAWKVETLPLR-LFPVK 73
Cdd:PRK14973 1 MHLIIAEKNIAANRIAQILAGKtkvQVKKDGgvsTYSFDDTVVVGLRGHVVEV----DFEPGYTNWRSEEHTPRsLIDAD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 74 YQPVESAAKQVKTILELIRRGDVTEIvhAGDPDDEGQLLVDEVLEY--AGNTK-PVKRVLINDNTLPAVKKALANLKDnR 150
Cdd:PRK14973 77 TIKKPTEKKIVGLIQKLAKKADRVTI--ATDFDTEGELIGKEAYELvrAVNPKvPIDRARFSAITKEEIVTAFAEPTD-L 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 151 DFkGLYLKALARSVADAVYGFSMTRAYTIPAKaRGYQGILSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMTGVFQRGAD 230
Cdd:PRK14973 154 DF-ALAAAGEARQIIDLIWGASLTRFISLAAH-RGGDNILSVGRVQSPTLAMIVDREKEIEAFVPEKYWMLSLATEKDGE 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 231 VLRANWKPGEFaplTDRKLLDKAWaDGTAAslagkPATVAAAATDDKKTAAPLPFNLVrlqQYM--NKKFKMTAQKTLDI 308
Cdd:PRK14973 232 GIEARHTHGRF---TDSAAAEAAY-DATKE-----PLVVTEVKEGHKVDRAPTPFDTT---TFIvaASRLGFSAANAMRI 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 309 TQQLREKyKAITYNRSDcsylsdeqfseapqvidalKSVFPQSLDID-------------------SARKSKAFNSAK-V 368
Cdd:PRK14973 300 AEDLYMN-GYISYPRTD-------------------NTIYPKSLDLNgvlatlakgafskdvawvkDNRRPVPTRGKKsS 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 369 TAHTAIIPTaSVPDVNALSTDERNVYQAIAQHYLVQFMPEKAYQEVSVAIQCGDESFCARARKTTDSGFEvflGAEPTDe 448
Cdd:PRK14973 360 TDHPPIHPT-GVATREELGDDRWKLYELVVRRFLATLSPDAEWATMKVNFDAGGEPYTATGGRLLEAGWR---TVYPYS- 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 449 gESEDNddsafeLLCKIRTGETLTTKEVVVNEKKTTPPPLFTEASLLAALvrvadfvtdptikkllkdkdkdkkdEHGGI 528
Cdd:PRK14973 435 -EAKEN------ILPAFALGEKLPILAVNLEEKETQPPARYSQSRLIQRM-------------------------EELGL 482
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 529 GTPATRAAILETLKKRNYItlEKGKLIPTDTGYALIDALPGIA---VNPDMTALWSEKQAAIENGDLTVEQFINELYGEL 605
Cdd:PRK14973 483 GTKSTRHEVIGKLVSRKYI--EGNPLRPTLVGRAVTESLEEHAgtiTEPDMTQTLEEHMQQIKERKRTRDDVVTESRKML 560
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1445118078 606 TGMISDVDLGEMKIepaapaGQ--FQRLDS-----PCPSCGKHIVIRPKG--YF--CTG---CEFKI 658
Cdd:PRK14973 561 HRAFDELEANEAVI------GRdiMERTAEeltigPCPVCGKDLRIKHIGssQFigCSGypdCTFNI 621
|
|
| PRK06319 |
PRK06319 |
DNA topoisomerase I/SWI domain fusion protein; Validated |
3-560 |
8.92e-30 |
|
DNA topoisomerase I/SWI domain fusion protein; Validated
Pssm-ID: 235778 [Multi-domain] Cd Length: 860 Bit Score: 126.09 E-value: 8.92e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 3 LFIAEKPAVANDIVKALGGNFTrhdgwFESDnaivtncFGHIIEsqppenynpeykawkvetLPLRLFPV--------KY 74
Cdd:PRK06319 5 LIIVESPAKIKTLQKLLGEGFI-----FASS-------LGHIVD------------------LPAKEFGIdiendfepDY 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 75 QPVESAAKQVKTILELIRRGDVTEIvhAGDPDDEGQLLVDEVLEYAGNTKPVKRVLINDNTLPAVKKALanlKDNRDFKG 154
Cdd:PRK06319 55 QILPDKEEVINKICKLAKKCDVVYL--SPDPDREGEAIAWHIANQLPKNTKIQRISFNAITKGAVTEAL---KHPREIDM 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 155 LYLKAL-ARSVADAVYGFSMTraytiPAKARGYQ--GILSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMtGVFQRGADV 231
Cdd:PRK06319 130 ALVNAQqARRLLDRIVGYKIS-----PILSRKLQrrSGVSAGRVQSVALKLVVDREKAIEAFVPVEYWNI-RVHLKDPKT 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 232 LRANW-------------KPGEFAPLTDRKLLD-KAWADGTAASLAGKPATVAAAATDDKKTAAPLPFNLVRLQQYMNKK 297
Cdd:PRK06319 204 QKTFWahlysvdgkkwekEIPEGKTEDEVLLINsKEKADHIVELLESATYTVTRVESKEKRRNAYPPFITSTLQQEASRH 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 298 FKMTAQKTLDITQQLREKYKA--------ITYNRSDCSYLSDEQFSEapqVIDALKSVFPQSLDIDSArksKAFNSAKVT 369
Cdd:PRK06319 284 FRFSSSRTMNIAQTLYEGVDLdsegatglITYMRTDSVRTDPEALKQ---VRKYIEGTFGKEFLPSSP---NVYTTKKMA 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 370 --AHTAIIPT--ASVPDV--NALSTDERNVYQAIAQHYLVQFMPEKAYQEVSVAIQCGDEsFCARArkttdSG----FEV 439
Cdd:PRK06319 358 qdAHEAIRPTdiTLTPEKlrSKLTEDQYKLYSLIWKRFVASQMIPAIYDTLAIRITTNKG-IDLRA-----TGsllkFKG 431
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 440 FLGAepTDEGESEDNDDSAFELLCKIRTGETLTTKEVVVNEKKTTPPPLFTEASLLAALvrvadfvtdptikkllkdkdk 519
Cdd:PRK06319 432 FLAV--YEEKRDDEGDEEENIHLPKLHEQDVLTKEELSAEQAFTKPLPRFTEASLVKEL--------------------- 488
|
570 580 590 600
....*....|....*....|....*....|....*....|.
gi 1445118078 520 dkkdEHGGIGTPATRAAILETLKKRNYITLEKGKLIPTDTG 560
Cdd:PRK06319 489 ----EKSGIGRPSTYATIMNKIQSREYTLKENQRLRPTELG 525
|
|
| TOP1Bc |
smart00436 |
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA ... |
126-220 |
4.50e-20 |
|
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA topoisomeraes I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase beta subunit
Pssm-ID: 214662 [Multi-domain] Cd Length: 89 Bit Score: 85.33 E-value: 4.50e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 126 VKRVLINDNTLPAVKKALANLKDNrdFKGLYLKALARSVADAVYGFSMTRAYTIpakaRGYQGILSVGRVQTPVLGLIVN 205
Cdd:smart00436 1 IKRIEFSEITKKAIREALKNPREI--DENLVNAQLARRILDRLIGFNLSRLLTK----KLRNGVLSAGRVQTPTLGLIVE 74
|
90
....*....|....*
gi 1445118078 206 RTRANQNHKSSFYYT 220
Cdd:smart00436 75 REREIKNFVPKPYWE 89
|
|
| TopG2 |
COG1110 |
Reverse gyrase [Replication, recombination and repair]; |
86-609 |
8.63e-19 |
|
Reverse gyrase [Replication, recombination and repair];
Pssm-ID: 440727 [Multi-domain] Cd Length: 1219 Bit Score: 91.57 E-value: 8.63e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 86 TILELIRR--GDVTEIVHAGDPDDEGQLLV-DEVLEYAGNTKPVKRVLINDNTLPAVKKALANLkdnRDFKGLYLKA-LA 161
Cdd:COG1110 739 EIVEALRElaTEVDEVLIGTDPDTEGEKIGwDVYNLLRPYAKNIKRIEFHEVTRKAILEALKNP---REIDENLVEAqIV 815
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 162 RSVADAVYGFSMTRAYTIPAKARGyqgiLSVGRVQTPVLGLIVNRTRANQNHKSSFYytmtgvfqrgadVLRANWKPGEF 241
Cdd:COG1110 816 RRIEDRWIGFTLSQKLWKVFGNRN----LSAGRVQTPVLGWIIERYEESRKSKKYLI------------ILTLENGRLEL 879
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 242 aPLTDRKLLDKAwadGTAASLAGKPATVAAAATDDKKTAAPlPFNLVRLQQYMNKKFKMTAQKTLDITQQLREKyKAITY 321
Cdd:COG1110 880 -SIEDLKEAEEV---RKALEKEVKVKVKKVEEEEEELNPLP-PYTTDTLLRDASRRLGLSAEETMRLAQDLFES-GLITY 953
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 322 NRSDCSYLSDEQFSEAPQVIdalksvfpqsldidsarkSKAFNSAKVT--------AHTAIIPTasvpdvNALSTDErnV 393
Cdd:COG1110 954 HRTDSTRVSDAGIAVAKEYI------------------SERFGEEYFKprrwgeggAHEAIRPT------RPLDAED--L 1007
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 394 YQAIAQ------------HYLV------QFMP--------EKAYQEVSVAIQcGDESFCARARKTTDSGFEVFLgaePTd 447
Cdd:COG1110 1008 RRLIEEgvielpipltrrHLRLydlifrRFMAsqmrpakvEKVKLRVSLELP-GGEIEEERIVEIIEDGFLLIY---PP- 1082
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 448 egesednddsaFELLCKIRTGEtLTTKEVVVneKKTTPPPLFTEASLLAALVRVadfvtdptikkllkdkdkdkkdehgG 527
Cdd:COG1110 1083 -----------IKVEPELKEGE-YKVTEVKI--RKVPKVPLYTQGDLVREMKER-------------------------G 1123
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 528 IGTPATRAAILETLKKRNYITLEK--GKLIPTDTGYA----LIDALPGIaVNPDMTALWSEKQAAIENGDLTVEQFINEL 601
Cdd:COG1110 1124 IGRPSTYAKIVETLLRRGYVVESKkgKKLVPTKLGIEvynyLSENFPDL-VSEERTRELEEKMDEIEEGEADYQDVLEEL 1202
|
....*...
gi 1445118078 602 YGELTGMI 609
Cdd:COG1110 1203 YNELRELV 1210
|
|
| Toprim_Crpt |
pfam13342 |
C-terminal repeat of topoisomerase; |
653-712 |
2.66e-17 |
|
C-terminal repeat of topoisomerase;
Pssm-ID: 463851 [Multi-domain] Cd Length: 60 Bit Score: 76.36 E-value: 2.66e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 653 GCEFKIWSEFSGKKITQAQAEKLVKSGKTDLIKGFKKKSGGTYDTVLVLEDKKTGKLGFP 712
Cdd:pfam13342 1 GCGFSIGKTIAGKKLSEEQVKELLTKGKTGLIKGFKSKKGKKFDAYLVLDDDEKVEFDFE 60
|
|
| PTZ00407 |
PTZ00407 |
DNA topoisomerase IA; Provisional |
95-565 |
1.04e-15 |
|
DNA topoisomerase IA; Provisional
Pssm-ID: 173597 [Multi-domain] Cd Length: 805 Bit Score: 81.14 E-value: 1.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 95 DVTEIVHAGDPDDEGQLLVDEVLE-----YAGNTKPVKRVLINDNTLPAVKKALANLKDNRDFKGLYLKALARSVADAVY 169
Cdd:PTZ00407 124 NVTEIILATDPDREGELIAVHALQtikrlYPKLKVPFSRAYMHSITEDGIRKAMRERHVEACDYDLANAAETRHAMDRIF 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 170 GF---SMTRAYTIPAKargyqgilSVGRVQTPVLGLIVNRTRAN----QNHKSSFYYTMTGVF-----QRGADVLRANwk 237
Cdd:PTZ00407 204 GFlgsSVVRAANSQMR--------SIGRVQTPALILINEREDKIkaflESNKSTFEVQAMCQFpsphgTTFSQVVTIT-- 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 238 pgefaplTDRKLLDKAWAD---------GTAASLAGKPATVAAAATDDKKTAAPLPFNLVRLQQYMNKKFKMTAQKTLDI 308
Cdd:PTZ00407 274 -------PDRKGGASHWATeaearrcleQWKLNNCTGFSVPLEPKPQPSVVPPPQPFTMATAIAKANRQLKYSSEMVSGC 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 309 TQQLREkYKAITYNRSDCSYLsDEqfSEAPQVIDALKSVFPQSL------------DIDSARKSKAFNSAKVT------- 369
Cdd:PTZ00407 347 LQDLFQ-LGHITYPRTDSTRI-DE--SALPDIYAAVKKEFGKEFlyrledrtvsaqEGKGSKKTGKKRSTKQKkgadtpv 422
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 370 -----AHTAIIPTASVPDVN--ALSTDERNVYQAIAQHYLVQFMPEKAYQEVSVAIQC----GD------------ESFC 426
Cdd:PTZ00407 423 gnvedAHEAIRPTNIDTTGEslSLSPPTRAVYDLVRRNTLAVFMIPMKTEKIVATVKFtsgsGEklefelqgkrvvEPGW 502
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 427 ARARKTTDSG-----FEVFLGAEPTDEGE------SEDNDDSAFELLCKIRTGE---TLTTKEVVVNEKKTTPPPLFTEA 492
Cdd:PTZ00407 503 TRAFHKGDKGttgpaEETDEDITAVEEGApvvpslSQEEFKAIMNLRSQLGSGVqkgFFELRSPQVRENRPVPPLPHSEG 582
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1445118078 493 SLLAALVRvadfvtdptikkllkdkdkdkkdehGGIGTPATRAAILETLKKRNYITL-EKGKLIPTDTGYALID 565
Cdd:PTZ00407 583 TLIEELKN-------------------------NGVGRPSTYPMIVKTLLARGYIAVnPKGRCETTPVGRMLVE 631
|
|
| YrdD |
COG0551 |
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ... |
58-656 |
4.59e-14 |
|
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];
Pssm-ID: 440317 [Multi-domain] Cd Length: 695 Bit Score: 75.67 E-value: 4.59e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 58 KAWKVETLPLRLFPVKYQPVESAAKQVKTILELIRRGDVTEIVHAGDPDDEGQLLVDEVLEYAGNTKPVKRVLINDNTLP 137
Cdd:COG0551 44 LVDLLLKEKLKKLVENEKLIAELDIKDLKKLKKDKKKKAKALAAALAAADDDAIEAAAAADEEEALKAAEALEAIRKAVV 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 138 AVKKALANLKDNRDFKGLYLKALARSVADAVYgfsmtRAYTIPAKARGYQGILSVGRVQTPVLGLIVNRTRANQNHKSSF 217
Cdd:COG0551 124 EEVKSRARKRAARAPADVAAAAAAAALARLLL-----LAAASRALRLLLLLAAGRLRLLSAVAAGLLELEELLKEFEEEE 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 218 YYTMTGVFQRGADVLRANWKPGEFAPLTDRKLLDKAWADGTAASLAGKPATVAAAATDDKKTAAPLPFNLVRLQQYMNKK 297
Cdd:COG0551 199 EEEAAEEEEEEEEAKKKKEEDKKKKKKKKKKDKEEETKAIKKKKKAAEAVLAAKKAAKEAKAKKELPTTTTDALPEALAT 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 298 FKMTAQKTLDITQQLR-----EKYKAITYNRSDCSYLSDEQFSEAPQVIDALKSVFPQSLDIDSARKSKAFNSAKVTAHT 372
Cdd:COG0551 279 TSLTAAAAASALAAALleeegELLYTGGYIRYTRTPKSSEADALAALEALKKIAEEPPDERAKKKKKKAKKKKASEAKET 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 373 AIIPTASVPDVNALSTDERnVYQAIAQHYLVQFMPEKAYQEVSVAIQCGDESFCARARKTTDSGFEVFLGAEPTDEGESE 452
Cdd:COG0551 359 TDHPPIPPTTAAALLELLE-DRKLLLELLVRRRFAAAADLAKVEELTKVEEADEEELVEAEGGLLEVLGEEEEDDEDEEE 437
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 453 DnddsafELLCKIRTGETLTTKEVVVNEKKTTPPPLFTEASLLAALvrvadfvtdptikkllkdkdkdkkdEHGGIGTPA 532
Cdd:COG0551 438 E------LLLPPLEEGEPLLLEELLLEKQTTTPPPRYTTELLLKKL-------------------------EEEGGGGRG 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 533 TRAAILETLKKRNYITLEKGKLIPTDTGYALIDALPGIAVNPDM---TALWSEKQAAIENGDLTVEQFINELYGELTGMI 609
Cdd:COG0551 487 TTATIIILILKRRYVVLEEKKTTPTELLVEVVLLLLLPFPKLEDtteTAEEEEALLDKEEGKEDKVVEIREEEYPFFKKL 566
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....
gi 1445118078 610 SDVDLGEMKIEPAAPAgqfQRLDSPCPSCGKHIVIR--PKGYF--CTG---CEF 656
Cdd:COG0551 567 LEIAEEEGEEELSEED---EVLGEKCPKCGKPLVIKkgRYGKFlgCSNypeCKY 617
|
|
| COG1754 |
COG1754 |
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown]; |
49-560 |
3.95e-11 |
|
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];
Pssm-ID: 441360 [Multi-domain] Cd Length: 892 Bit Score: 66.38 E-value: 3.95e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 49 PPENYNPEYKAWKVETLPLRLFPVKYQPVESAAKQVKTILELIRRGDVTEIVHagDPDDEGQLLVDEVLEyagnTKPVKR 128
Cdd:COG1754 44 KADDKVVDDDDKKDDVDDDKKKKKKLLKAAAKKKKALALALAADDEDEELLAA--DDELEEEKVIKLLLL----ELAVER 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 129 VLINDNTlpAVKKALANLKDNRDFKGLYLKALARSVADAVYGFSMTRAYTIPAKARGYQGILSVGRVQTPVLGLIVNRTR 208
Cdd:COG1754 118 VARAAAV--RAAAAEAARLAALLRRRLVLRRLVRRLLVRLLLLRLVLLLLRLLVARRAARRRRRRRRRRARRRELERRRE 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 209 ANQNHKSSFYYTMTGVFQRGADVLRAnwkpGEFAPLTDRKLLDKAWADGTAASLAGKPATVAAAATDDKKTAAPLPFNLV 288
Cdd:COG1754 196 RARAAEAEEAAAAAAAAADAGRAAAA----RDGKGGGKLAAGGAAAAAAAAAAAAAAAAALAEAAAAAAVREPPTPTTTT 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 289 RLQQYMNKKFKMTAQKTLDITQQLREK-------YKAITYNRSDCSYLSDEQFSEAPQVIDALKSVFPQSLDIDSARKSK 361
Cdd:COG1754 272 TAQAATTTTTRAAAARTTRSAQQAARRtrlggegTYTTTTTTTTTTSAAAAAAAAAAAALAAAAAAAYAPPPPYYYKKKA 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 362 AFNSAKVTAHTAIIPTASVPDVNALSTDERNVYQ-----AIAQHYLVQFMPEKAYQEVSVAIQCGDESFCARARKTTDSG 436
Cdd:COG1754 352 AAAAAAAAAAAAAAARRPPAARAALLSDDRLLLEllllrRTAAAAAAAAAATATTTAAAAAAGAGAVGTAAAGAVFFFGG 431
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 437 FEVFLGAEPTDEGESEDNDDSAfellckIRTGETLTTKEVVVNEKKTTPPPLFTEASLLAALVRVadfvtdptikkllkd 516
Cdd:COG1754 432 FLLFAEEEDDDEEDDDDDDLPA------LEEGLPLLKEGVLADQHFTQPPPRYTEAPLVKRMEEL--------------- 490
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 1445118078 517 kdkdkkdehgGIGTPATRAAILETLKKRNYITLEKGKLIPTDTG 560
Cdd:COG1754 491 ----------GIGRPSTYASILSTLADRIYVRLDKRRLIPEDKG 524
|
|
| TOPRIM_TopoIA_TopoI |
cd03363 |
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA ... |
1-145 |
5.38e-07 |
|
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173783 [Multi-domain] Cd Length: 123 Bit Score: 49.10 E-value: 5.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 1 MRLFIAEKPAVANDIVKALGGNFtrhdgwfesdnaIVTNCFGHIIESQPPENYNP-EYKAWKvetlplrlfPvKYQPVES 79
Cdd:cd03363 1 KKLVIVESPAKAKTIKKYLGKEY------------EVLASVGHIRDLPKKGLGVDgEDDGFE---------P-KYVVIPG 58
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1445118078 80 AAKQVKTILELIRRGDvtEIVHAGDPDDEGQLLVDEVLEYAGNTKPVKRVLINDNTLPAVKKALAN 145
Cdd:cd03363 59 KKKVVKELKKLAKKAD--EIYLATDPDREGEAIAWHLAEVLKLKKNVKRVVFNEITKEAIKEALKN 122
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
2-132 |
2.87e-05 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 43.11 E-value: 2.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 2 RLFIAEKPAVANDIVKALGGNFTRhdgwfesdnaiVTNCFGHIIEsqppenynpeykawkvetlplrlfpvkyQPVESAA 81
Cdd:pfam01751 1 ELIIVEGPSDAIALEKALGGGFQA-----------VVAVLGHLLS----------------------------LEKGPKK 41
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1445118078 82 KQVKTILELIRRGDvtEIVHAGDPDDEGQLLVDEVLEYAG-NTKPVKRVLIN 132
Cdd:pfam01751 42 KALKALKELALKAK--EVILATDPDREGEAIALKLLELKElLENAGGRVEFS 91
|
|
| TOPRIM |
smart00493 |
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins; |
1-122 |
1.76e-03 |
|
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins;
Pssm-ID: 214695 [Multi-domain] Cd Length: 75 Bit Score: 37.63 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1445118078 1 MRLFIAEKPAVANDIVKALGGNFtrhdgwfesdnaIVTNCFGHIiesqppenynpeykawkvetlplrlfpvkyqpveSA 80
Cdd:smart00493 1 KVLIIVEGPADAIALEKAGGKRG------------NVVALGGHL----------------------------------LS 34
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1445118078 81 AKQVKTILELIRRgdvTEIVHAGDPDDEGQLLVDEVLEYAGN 122
Cdd:smart00493 35 KEQIKLLKKLAKK---AEVILATDPDREGEAIAWELAELLKP 73
|
|
| |
