NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1468674266|ref|WP_117548161|]
View 

MULTISPECIES: carbohydrate ABC transporter permease [Longicatena]

Protein Classification

carbohydrate ABC transporter permease( domain architecture ID 10003067)

carbohydrate ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter responsible for the translocation across the membrane of one or more from a variety of carbohydrate substrates including trehalose, lactose, arabinose, and maltodextrin

Gene Ontology:  GO:0042626|GO:0140359|GO:0008643|GO:0055085
PubMed:  25750732|24638992|30626703
TCDB:  3.A.1.1.-

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
4-290 4.48e-64

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 203.44  E-value: 4.48e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266   4 KKAQRTFIFGCLAPAVILAILFIAVPTITVFKESFFDKTDLIHDGAFVALDNFKVLFSDERFIESMQNIILTITLVTLVT 83
Cdd:COG1175    13 RRRRRLAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGPPPEFVGLDNYARLFTDPRFWNALGNTLLFTVVSVPLQ 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  84 LVLAVLFATLLTREeFRGKNFFRVIFYIPNILSIVVIAGIFAAIYQPSNGILNSFLEMIGLSGLtrAWMGDPDIVNYSII 163
Cdd:COG1175    93 LVLGLLLALLLNRK-LRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGLEPI--NWLGDPSLALPAVI 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266 164 VALIWQAIGYYMVMYMASMSSIPENLYEAASLEGAGKIKQFFMITLPLIWNNIRTTLTFFVISTINlSFMFVQINTEGSL 243
Cdd:COG1175   170 IVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQ-VFDLVYVLTGGGP 248

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1468674266 244 G--TEVPLNYMYNKAF-AGNYSYGMAAGVCIFLFSFALSGILNNITKRDV 290
Cdd:COG1175   249 GnsTTTLVLYIYQTAFqQFDFGYASAIAVVLFLIILVLTLLQLRLLRRRE 298
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
4-290 4.48e-64

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 203.44  E-value: 4.48e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266   4 KKAQRTFIFGCLAPAVILAILFIAVPTITVFKESFFDKTDLIHDGAFVALDNFKVLFSDERFIESMQNIILTITLVTLVT 83
Cdd:COG1175    13 RRRRRLAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGPPPEFVGLDNYARLFTDPRFWNALGNTLLFTVVSVPLQ 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  84 LVLAVLFATLLTREeFRGKNFFRVIFYIPNILSIVVIAGIFAAIYQPSNGILNSFLEMIGLSGLtrAWMGDPDIVNYSII 163
Cdd:COG1175    93 LVLGLLLALLLNRK-LRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGLEPI--NWLGDPSLALPAVI 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266 164 VALIWQAIGYYMVMYMASMSSIPENLYEAASLEGAGKIKQFFMITLPLIWNNIRTTLTFFVISTINlSFMFVQINTEGSL 243
Cdd:COG1175   170 IVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQ-VFDLVYVLTGGGP 248

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1468674266 244 G--TEVPLNYMYNKAF-AGNYSYGMAAGVCIFLFSFALSGILNNITKRDV 290
Cdd:COG1175   249 GnsTTTLVLYIYQTAFqQFDFGYASAIAVVLFLIILVLTLLQLRLLRRRE 298
malF PRK10999
maltose ABC transporter permease MalF;
90-283 9.65e-18

maltose ABC transporter permease MalF;


Pssm-ID: 236816 [Multi-domain]  Cd Length: 520  Bit Score: 83.09  E-value: 9.65e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  90 FATLLTREEFRGKNFFRVI----FYIPNILSIVVIAGIFaaiyQPSNGILNSFLEmiGLSGLTRAWMGDPDIVNYSIIVA 165
Cdd:PRK10999  308 LACLVQWEALKGKAVYRVLlilpYAVPSFISILIFKGLF----NQSFGEINMMLS--ALFGIKPAWFSDPTLAKTMILIV 381

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266 166 LIWQAIGYYMVMYMASMSSIPENLYEAASLEGAGKIKQFFMITLPLIwnnIRtTLTFFVIStinlSFMF-------VQIN 238
Cdd:PRK10999  382 NTWLGYPYMMILCMGLLKAIPDDLYEASAMDGAGPFQNFFKITLPLL---IK-PLTPLMIA----SFAFnfnnfvlIQLL 453

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1468674266 239 TEGS---LGTEVP-------LNYMYNKAF--AGNYSYGMAAGVC--IFLFSFALSgILN 283
Cdd:PRK10999  454 TNGGpdmIGTTTPagytdllVSYTYRIAFegGGGQDFGLAAAIAtlIFLLVGALA-ILN 511
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 12-210 4.12e-17

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 81.27  E-value: 4.12e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  12 FGCLAPAVILAILFIAVPTITVFKESFFDKtdlihDGAFVALDNFKVLFSDERFIESMQNIILTITLVTLVTLVLAVLFA 91
Cdd:TIGR03262   4 RLLLAGMILALLLFLLLPLLALLTKSVYDS-----DGDFIGLANFAEYFATPGLLQSLGNSLTVSAIVTAIVVPLAFAFA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  92 TLLTREEFRGKNFFRVIFYIPnILSIVVIAGIfaaiyqpsngilnSFLEMIGLSGLTRAWMGDPDIVNY-SIIVALIWQA 170
Cdd:TIGR03262  79 YALTRSRIPGKGAFRLVALLP-LLAPSLLPAI-------------SLIYLFGNQGLLKGLLGGFSIYGFwGIVIGEVFYT 144

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1468674266 171 IGYYMVMYMASMSSIPENLYEAASLEGAGKIKQFFMITLP 210
Cdd:TIGR03262 145 FPHALMILVTALSLADGRLYEAARAMGASPWRTFFTVTLP 184
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 90-276 3.45e-07

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 49.58  E-value: 3.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  90 FATLLTREEFRGKNFFRVIFYIPNILSIVVIAGIFAAIYqpsngilnsflemiglsGLTRAWMGDPDIVNYSIIVALIWQ 169
Cdd:cd06261    22 LGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLF-----------------GVLLGWGILPGLGLPALILALLLI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266 170 AiGYYMVMYMASMSSIPENLYEAASLEGAGKIKQFFMITLPLIWNNIRTTLTFFVISTINLSFMFVQINTEGSLGTEVPL 249
Cdd:cd06261    85 A-PFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGTGL 163

                         170       180
                  ....*....|....*....|....*..
gi 1468674266 250 NYMYNKAFAGNYSYGMAAGVCIFLFSF 276
Cdd:cd06261   164 LLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 161-288 1.09e-06

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 48.06  E-value: 1.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266 161 SIIVALIWQAIGYYMVMYMASMSSIPENLYEAASLEGAGKIKQFFMITLPLIWNNIRTTLTFFVISTINLSFMFVQINTE 240
Cdd:pfam00528  54 PAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSW 133

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1468674266 241 GSLGTEVPLNYMYnKAFAGNYSYGMAAGVCIFLFSFALSGILNNITKR 288
Cdd:pfam00528 134 PGLGLLLIEAILG-YDYPEIQGPVLAAALILLLLNLLVDILQRLLDPR 180
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
4-290 4.48e-64

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 203.44  E-value: 4.48e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266   4 KKAQRTFIFGCLAPAVILAILFIAVPTITVFKESFFDKTDLIHDGAFVALDNFKVLFSDERFIESMQNIILTITLVTLVT 83
Cdd:COG1175    13 RRRRRLAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGPPPEFVGLDNYARLFTDPRFWNALGNTLLFTVVSVPLQ 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  84 LVLAVLFATLLTREeFRGKNFFRVIFYIPNILSIVVIAGIFAAIYQPSNGILNSFLEMIGLSGLtrAWMGDPDIVNYSII 163
Cdd:COG1175    93 LVLGLLLALLLNRK-LRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGLEPI--NWLGDPSLALPAVI 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266 164 VALIWQAIGYYMVMYMASMSSIPENLYEAASLEGAGKIKQFFMITLPLIWNNIRTTLTFFVISTINlSFMFVQINTEGSL 243
Cdd:COG1175   170 IVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQ-VFDLVYVLTGGGP 248

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1468674266 244 G--TEVPLNYMYNKAF-AGNYSYGMAAGVCIFLFSFALSGILNNITKRDV 290
Cdd:COG1175   249 GnsTTTLVLYIYQTAFqQFDFGYASAIAVVLFLIILVLTLLQLRLLRRRE 298
LplB COG4209
ABC-type polysaccharide transport system, permease component [Carbohydrate transport and ...
 15-288 3.22e-32

ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 443357 [Multi-domain]  Cd Length: 316  Bit Score: 120.97  E-value: 3.22e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  15 LAPAVILAILFIAVP---TITVFKEsfFDKTDLIHDGAFVALDNFKVLFSDERFIESMQNIILTITLVTLVTLVLAVLFA 91
Cdd:COG4209    33 LLPGLIYLLIFSYLPmygIVIAFKD--YNPFKGIFGSPWVGLKNFKFLFSSPDFWRVLRNTLLISLLKLVFGFPLPIILA 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  92 TLLTreEFRGKNFFRV---IFYIPNILSIVVIAGIFAAIYQPSNGILNSFLEMIGLSGLtrAWMGDPDIVNYSIIVALIW 168
Cdd:COG4209   111 LLLN--ELRSKRFKKTvqtISYLPHFLSWVVVAGIVYQFLSPDTGLVNQLLRALGGEPI--NFLTEPKYFRPIYVFSGIW 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266 169 QAIGYYMVMYMASMSSIPENLYEAASLEGAGKIKQFFMITLPLIWNNIRTTLTFFVISTINLSF--MFVQINTEGSLGTE 246
Cdd:COG4209   187 KEAGWGSIIYLAAITGIDPELYEAAAIDGAGRWQQIWHITLPGIRPTIVILLILNIGNILNVGFeqIYLLYNPLNYSTSD 266

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1468674266 247 VPLNYMYNKAFA-GNYSYGMAAGVCIFLFSFALSGILNNITKR 288
Cdd:COG4209   267 VIDTYVYRIGLQnGDYSYATAVGLFKSVVGLILVLIANKIAKK 309
malF PRK10999
maltose ABC transporter permease MalF;
90-283 9.65e-18

maltose ABC transporter permease MalF;


Pssm-ID: 236816 [Multi-domain]  Cd Length: 520  Bit Score: 83.09  E-value: 9.65e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  90 FATLLTREEFRGKNFFRVI----FYIPNILSIVVIAGIFaaiyQPSNGILNSFLEmiGLSGLTRAWMGDPDIVNYSIIVA 165
Cdd:PRK10999  308 LACLVQWEALKGKAVYRVLlilpYAVPSFISILIFKGLF----NQSFGEINMMLS--ALFGIKPAWFSDPTLAKTMILIV 381

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266 166 LIWQAIGYYMVMYMASMSSIPENLYEAASLEGAGKIKQFFMITLPLIwnnIRtTLTFFVIStinlSFMF-------VQIN 238
Cdd:PRK10999  382 NTWLGYPYMMILCMGLLKAIPDDLYEASAMDGAGPFQNFFKITLPLL---IK-PLTPLMIA----SFAFnfnnfvlIQLL 453

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1468674266 239 TEGS---LGTEVP-------LNYMYNKAF--AGNYSYGMAAGVC--IFLFSFALSgILN 283
Cdd:PRK10999  454 TNGGpdmIGTTTPagytdllVSYTYRIAFegGGGQDFGLAAAIAtlIFLLVGALA-ILN 511
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 12-210 4.12e-17

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 81.27  E-value: 4.12e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  12 FGCLAPAVILAILFIAVPTITVFKESFFDKtdlihDGAFVALDNFKVLFSDERFIESMQNIILTITLVTLVTLVLAVLFA 91
Cdd:TIGR03262   4 RLLLAGMILALLLFLLLPLLALLTKSVYDS-----DGDFIGLANFAEYFATPGLLQSLGNSLTVSAIVTAIVVPLAFAFA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  92 TLLTREEFRGKNFFRVIFYIPnILSIVVIAGIfaaiyqpsngilnSFLEMIGLSGLTRAWMGDPDIVNY-SIIVALIWQA 170
Cdd:TIGR03262  79 YALTRSRIPGKGAFRLVALLP-LLAPSLLPAI-------------SLIYLFGNQGLLKGLLGGFSIYGFwGIVIGEVFYT 144

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1468674266 171 IGYYMVMYMASMSSIPENLYEAASLEGAGKIKQFFMITLP 210
Cdd:TIGR03262 145 FPHALMILVTALSLADGRLYEAARAMGASPWRTFFTVTLP 184
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 1-289 1.14e-16

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 78.27  E-value: 1.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266   1 MNKKKAQRTFIFGCLAPAVILAILFIAVPTITVFKESFFDKTDLIHDGAFVALDNFKVLFSDERFIESMQNIILTITLVT 80
Cdd:COG1176     1 MSAALRRRLRPLLLLLPALLWLLLFFVLPLLLLLVYSFTTRDPYGGVVPGFTLENYARLFTDPLYLKVLLRTLWIALLTT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  81 LVTLVLAVLFATLLTREEFRGKNFFRVIFYIPNILSIVVIAGIFAAIYQPsNGILNSFLEMIGLSGLTRAWMGDPdivnY 160
Cdd:COG1176    81 LICLLLGYPIAYFLARAPPRWRNLLLLLVILPFWTSFLVRTYAWIVLLGR-NGLLNSLLLALGLIDEPLRLLYTE----F 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266 161 SIIVALIWQAIGYYMVMYMASMSSIPENLYEAASLEGAGKIKQFFMITLPLIWNNIRTTLTFFVISTINlSFMFVQInte 240
Cdd:COG1176   156 AVVIGLVYVYLPFMVLPLYAALEKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALG-AFVTPAL--- 231

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1468674266 241 gsLGTEVPL---NYMYNKAF-AGNYSYGMAAGVCIFLFSFALSGILNNITKRD 289
Cdd:COG1176   232 --LGGGKVLmigNLIYQQFLsALNWPLAAALAVVLLLIVLLVLLLYLRLLRRR 282
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
50-234 1.85e-15

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 74.86  E-value: 1.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  50 FVALDNFKVLFSDERFIESMQNIILTITLVTLVTLVLAVLFATLLTREeFRGKNFFRVIFYIPNILSIVVIAGIFAAIYQ 129
Cdd:PRK10561   38 FVGLDNFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAALVDYV-VRGSRFYQTLMLLPYAVAPAVAAVLWIFLFN 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266 130 PSNGILNSFLEMIGLSGLTRAWMGDpdiVNYSIIVALIWQAIGYYMVMYMASMSSIPENLYEAASLEGAGKIKQFFMITL 209
Cdd:PRK10561  117 PGRGLITHFLAEFGYDWNHAQNSGQ---AMFLVVFASVWKQISYNFLFFFAALQSIPRSLVEAAAIDGAGPIRRFFKLAL 193

                         170       180
                  ....*....|....*....|....*
gi 1468674266 210 PLIwnnirTTLTFFVIsTINLSFMF 234
Cdd:PRK10561  194 PLI-----APVSFFLL-VVNLVYAF 212
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
1-282 1.95e-13

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 70.19  E-value: 1.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266   1 MNKKKAQRTFIFgcLAPAVILAILFIAVPTITVFKESFFDKtdlihdgafvaLDNFKVLFSDERFIESMQNIILTITLVT 80
Cdd:COG1178     1 MSTRPRRRPRLL--LLLLALLLALLVLLPLLALLLRAFTDG-----------LANFWALLSDPYLWRALGNTLLLALLVT 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  81 LVTLVLAVLFATLLTREEFRGKNFFRVIFYIPNILSIVVIAGIFAAIYQPsNGILNSFLemiglsgltRAWMG--DPDIv 158
Cdd:COG1178    68 LLSLLLGVPLAWLLARTDFPGRRLLRWLLLLPLALPPYVVALAWIALFGP-NGLLNTLL---------RALFGlePPDI- 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266 159 nYSIIVALIWQAIGYYMVMYM---ASMSSIPENLYEAASLEGAGKIKQFFMITLPLIWNNIrttltffvISTINLSFMFv 235
Cdd:COG1178   137 -YGLGGIILVLVLFNYPYVYLllrAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAI--------AAGALLVFLL- 206

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1468674266 236 qinTEGSLGTEVPLNYMYN-------KAFAGNYSYGMAAGVCIFLFSFALSGIL 282
Cdd:COG1178   207 ---CLADFGTPLVLGGGYTtlttaiyQAWLGDFDLGAAAALALVLLLLVLLLLL 257
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 19-288 5.52e-12

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 64.36  E-value: 5.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  19 VILAILFIAVPTITVFKESFFDKTDLIHDGAFVALDNFKVLFSDERFIESMQNIILTITLVTLVTLVLAVLFATLLTREE 98
Cdd:COG1177    13 LALVLLFLYLPILVLVLYSFNDSWFLTFPPEGFTLRWYAELFSDPRLLDALLNSLLIALLSTLLATVLGTPAALALARYR 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  99 FRGKNFFRVIFYIPNILSIVVIagifaaiyqpsnGIlnSFLEMIGLSGLTRAWMGdpdivnysIIVALIWQAIGYYMVMY 178
Cdd:COG1177    93 FRGRRLLLALLLLPLVVPGIVL------------GV--ALLLLFSALGLSGGLWG--------LILAHVVFTLPFVVLVV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266 179 MASMSSIPENLYEAASLEGAGKIKQFFMITLPLIWNNIRTTLTF-FVIS--TINLSFMFVqinteGSLGTEVPLnYMYNK 255
Cdd:COG1177   151 LARLQGFDPSLEEAARDLGASPWQTFRRVTLPLIAPGILAGALLaFTLSfdEFVITLFLA-----GPGVTTLPV-YIYSM 224

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1468674266 256 AFAGNYSYGMAAGVCIFLFSFALSGILNNITKR 288
Cdd:COG1177   225 IRRGISPEINALSTLLILLSLLLLLLAERLRRR 257
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
18-289 5.27e-09

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 56.71  E-value: 5.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  18 AVILAILFIAVPTITVFKESFfdkTDLIHDGafVALDNFKVLFSDERFIESMQNIILTITLVTLVTLVLAVLFATLLTRE 97
Cdd:COG1178   294 CLLLVLLGLLLPLLALLLWSL---TKALDDN--LTLDNYRFVLLDPSLLRALLNSLLLALLAALLAVLLALLLAYLVRRR 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  98 EFRGKNFFRVIFYIPNILSIVVIA-GIFAAIYQPSNGILnsflemiglsgltrawmgdpdivnYSIIVALIWqaigYYMV 176
Cdd:COG1178   369 RGRLARLLDRLAMLPYAVPGIVLGlGLLLLFNRPLPLLL------------------------YGTLAILVL----AYVV 420

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266 177 MYM--------ASMSSIPENLYEAASLEGAGKIKQFFMITLPLIWNNIRTTLTF-FVIS--TINLSFMFVQINTEgSLGT 245
Cdd:COG1178   421 RFLpfalrsleAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLvFVTSmkELSATLLLRPPGFE-TLAV 499

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1468674266 246 evplnYMYNKAFAGNYSYGMAAGVCIFLFSFALSGILNNITKRD 289
Cdd:COG1178   500 -----LIYQLASSGRYGEAAALALLLVLVSLLPVLLLERLLGRR 538
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 91-222 9.79e-08

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 52.06  E-value: 9.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  91 ATLLTREEFRGKNFFRVIFYIPNILSIVViAGI-FAAIYQPsNGILNSFLEMIGLSgltrawmgdpdiVNYS---IIVAL 166
Cdd:COG0555    78 AWVLVRYRFPGKRLVDALVDLPFALPTAV-AGIaLLLLFGP-NGWLGQLLAPLGIK------------VAFTplgIVLAQ 143

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1468674266 167 IWQAIGYYMVMYMASMSSIPENLYEAASLEGAGKIKQFFMITLPLIWNNIRT--TLTF 222
Cdd:COG0555   144 TFVSLPFVVRTVQPVLEELDPELEEAAATLGASRWQTFRRVILPLLLPALLTgfALAF 201
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 90-276 3.45e-07

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 49.58  E-value: 3.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  90 FATLLTREEFRGKNFFRVIFYIPNILSIVVIAGIFAAIYqpsngilnsflemiglsGLTRAWMGDPDIVNYSIIVALIWQ 169
Cdd:cd06261    22 LGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLF-----------------GVLLGWGILPGLGLPALILALLLI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266 170 AiGYYMVMYMASMSSIPENLYEAASLEGAGKIKQFFMITLPLIWNNIRTTLTFFVISTINLSFMFVQINTEGSLGTEVPL 249
Cdd:cd06261    85 A-PFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGTGL 163

                         170       180
                  ....*....|....*....|....*..
gi 1468674266 250 NYMYNKAFAGNYSYGMAAGVCIFLFSF 276
Cdd:cd06261   164 LLIFAILFPGDLGVAAAVALILLLLSL 190
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 18-234 6.21e-07

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 49.71  E-value: 6.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  18 AVILAILFIAVPTITVFKESFFDKTDLIHDGAF-----VALDNFKVLFSDERFIESMQNIILTITLVTLVTLVLAVLFAT 92
Cdd:COG0395    20 LLILLALLFLFPLYWMVVTSFKPPAEIFSGPPSllpseFTLENYRAAFTDGPFGRYLLNSLIVAVVSTVLSLLLSSLAAY 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  93 LLTREEFRGKNFFRVIF----YIPNILSIVVIAGIFAAIyqpsnGILNSFLemiglsgltrawmgdpdivnySIIVALIW 168
Cdd:COG0395   100 ALARFRFRGRKLLFLLIlatlMIPGQVLLIPLYLLFRQL-----GLLNTYW---------------------GLILPYLA 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1468674266 169 QAIGYYMVMYMASMSSIPENLYEAASLEGAGKIKQFFMITLPLIWNNIRTTLTFFVISTINlSFMF 234
Cdd:COG0395   154 FGLPFGIFLLRQFFRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWN-DFLW 218
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 161-288 1.09e-06

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 48.06  E-value: 1.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266 161 SIIVALIWQAIGYYMVMYMASMSSIPENLYEAASLEGAGKIKQFFMITLPLIWNNIRTTLTFFVISTINLSFMFVQINTE 240
Cdd:pfam00528  54 PAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSW 133

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1468674266 241 GSLGTEVPLNYMYnKAFAGNYSYGMAAGVCIFLFSFALSGILNNITKR 288
Cdd:pfam00528 134 PGLGLLLIEAILG-YDYPEIQGPVLAAALILLLLNLLVDILQRLLDPR 180
modB PRK09421
molybdate ABC transporter permease subunit;
90-216 4.41e-06

molybdate ABC transporter permease subunit;


Pssm-ID: 181841  Cd Length: 229  Bit Score: 46.84  E-value: 4.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  90 FATLLTREEFRGKNFFRVIFYIPNILSIVVIaGIFAAIYQPSNGILNSFL-EMIGLSgLTRAWMGdpdIVNYSIIVA--L 166
Cdd:PRK09421   32 VAWLLARCRFPGKSLLDSLLHLPLVLPPVVT-GYLLLISMGRRGFIGQWLyEWFGIS-FAFSWRG---AALAAAVMAfpL 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1468674266 167 IWQAIgyymvmyMASMSSIPENLYEAASLEGAGKIKQFFMITLPLIWNNI 216
Cdd:PRK09421  107 MVRAI-------RLSLEAVDRKLEQAARTLGASPWRVFFTITLPLTLPGI 149
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 20-211 1.68e-04

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 42.45  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  20 ILAILFIAVPTITVFKESFFDKTDLIHDGAF---VALDNFKVLFSDERFIESMQNIILTITLVTLVTLVLAVLFATLLTR 96
Cdd:COG3833    23 IILAIIALFPILWVVSASFNPGGSLYSSSLIpenFTLENYKKLFTETPFLRWFLNSLIVAVVTAIISVFLAALAAYAFSR 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  97 EEFRGKNFFRVIFYI----PNILSIVVIAGIFAAIyqpsnGILNSFLemiglsGLTRAWMGDPDIVNysiivalIWQAIG 172
Cdd:COG3833   103 FRFKGRKAGLLALLLlqmfPAFLALVALYLLLSAL-----GLLNTLL------GLILVYLGGAIPFN-------TWLMKG 164

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1468674266 173 YymvmymasMSSIPENLYEAASLEGAGKIKQFFMITLPL 211
Cdd:COG3833   165 Y--------FDTIPKELDEAAKIDGASHFQIFFRIILPL 195
cysW PRK11602
sulfate/thiosulfate ABC transporter permease CysW;
19-227 7.74e-04

sulfate/thiosulfate ABC transporter permease CysW;


Pssm-ID: 183225  Cd Length: 283  Bit Score: 40.51  E-value: 7.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  19 VILAILFIAVPTITVFKESFfdktdliHDGAFVALDNFkvlfSDERFIESMQNIILTITLVTLVTLVLAVLFATLLTREE 98
Cdd:PRK11602   27 MLVSAFILVVPMIYIFVQAF-------SKGLMPVLQNL----ADPDMLHAIWLTVLIALIAVPVNLVFGILLAWLVTRFN 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468674266  99 FRGKNFFRVIFYIPNILSIVViAGIFAAIYQPSNGILNSFLEMIGLSgLTRAWmgdPDIVNYSIIVALIWqaIGYYMVMY 178
Cdd:PRK11602   96 FPGRQLLLTLLDIPFAVSPVV-AGLVYLLFYGSNGPLGGWLDEHNLQ-LMFSW---PGMVLVTIFVTCPF--VVRELVPV 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1468674266 179 MASMSSIPEnlyEAASLEGAGKIKQFFMITLPliwnNIRTTLTFFVIST 227
Cdd:PRK11602  169 MLSQGSQED---EAAILLGASGWQMFRRVTLP----NIRWALLYGVVLT 210
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH