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Conserved domains on  [gi|1561178664|ref|WP_128477363|]
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DNA-directed RNA polymerase subunit B [Halorussus pelagicus]

Protein Classification

DNA-directed RNA polymerase subunit B'( domain architecture ID 11482643)

DNA-directed RNA polymerase subunit B' is part of the DNA-dependent RNA polymerase, which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. In Archaea, the B subunit corresponding to the eukaryotic Rpb1 is split in two, subunits B'' and B' respectively.

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK07225 PRK07225
DNA-directed RNA polymerase subunit B'; Validated
3-608 0e+00

DNA-directed RNA polymerase subunit B'; Validated


:

Pssm-ID: 235972 [Multi-domain]  Cd Length: 605  Bit Score: 1274.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664   3 QGREAKVYVNGSLVGTHPDPEQLAEQVRHARRRGDVSEMVNVSVKERTREVIINADAGRARRPLLVVEDGKPLATEEEVE 82
Cdd:PRK07225    1 MMRKAKVYVNGKLIGTHDDPEELVEEIREARRSGEISEEVNVSYKEETNEVIINTDAGRARRPLIVVENGEPLLTEEHIE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  83 ALKNGDLDFDDLVERGKVEFIDAEEEEDIYVAVDEDDLSEDHTHLEVDPQLIFGIGAGMVPYPEHNASPRITMGSGMIKQ 162
Cdd:PRK07225   81 KLKNGELTFDDLVKQGVIEYLDAEEEENAYIAVYEEDLTEEHTHLEIDPSLILGIGAGMIPYPEHNASPRITMGAGMIKQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 163 SLGLPAANYRIRPDTRQHLLHYPQLSMVKTQTTEQIGYDDRPAAQNFTVAVMSYEGFNIEDALVLNAGSVDRALARSHFF 242
Cdd:PRK07225  161 SLGLPAANYKLRPDTRGHLLHYPQVPLVKTQTQEIIGFDERPAGQNFVVAVMSYEGYNIEDALIMNKASIERGLGRSHFF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 243 RTYEGEERRYPGGQEDRFEIPSDDVRGARGEDAYTHLDDDGLVNPETRVDESSVLLGKTSPPRFLEEPDDMGgLSPQKRR 322
Cdd:PRK07225  241 RTYEGEERRYPGGQEDRFEIPDKDVRGYRGEEAYRHLDEDGLVNPETEVKEGDVLIGKTSPPRFLEEPDDFG-ISPEKRR 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 323 ETSVTMRSGESGIVDTVTLMEGEDGSKLSKVSVRDERIPELGDKFASRHGQKGVVGHIAPQEDMPFTEQGVVPDLIINPH 402
Cdd:PRK07225  320 ETSVTMRSGEEGIVDTVILTETEEGSRLVKVRVRDLRIPELGDKFASRHGQKGVIGLIVPQEDMPFTESGVVPDLIINPH 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 403 ALPSRMTVGHVLEMIGGKVGALEGRRVDGTPFTGEDEDELRGGLEEQGFKSSGKEIMYSGVTGEKIEAEIFIGTIFYQKL 482
Cdd:PRK07225  400 AIPSRMTVGHVLEMIGGKVGSLEGRRVDGTAFSGEDEEDLREALEKLGFEHTGKEVMYDGITGEKIEAEIFVGVIYYQKL 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 483 YHMVSNKLHARSRGPVQVLTRQPTEGRAREGGLRVGEMERDVLIGHGAALTLKERLLDESDREWIYVCANCGMSAVENVE 562
Cdd:PRK07225  480 HHMVANKLHARSRGPVQVLTRQPTEGRAREGGLRFGEMERDVLIGHGAAMLLKERLLDESDKVEIYVCAKCGMIAIYDKK 559
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*.
gi 1561178664 563 QNRVYCPNCDEETDIHEIEMSYAFKLLLDEMKALGIAPRLELEDAV 608
Cdd:PRK07225  560 RNRKYCPICGEETDIYPVEMSYAFKLLLDELKSLGIAPRLELEDKV 605
 
Name Accession Description Interval E-value
PRK07225 PRK07225
DNA-directed RNA polymerase subunit B'; Validated
3-608 0e+00

DNA-directed RNA polymerase subunit B'; Validated


Pssm-ID: 235972 [Multi-domain]  Cd Length: 605  Bit Score: 1274.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664   3 QGREAKVYVNGSLVGTHPDPEQLAEQVRHARRRGDVSEMVNVSVKERTREVIINADAGRARRPLLVVEDGKPLATEEEVE 82
Cdd:PRK07225    1 MMRKAKVYVNGKLIGTHDDPEELVEEIREARRSGEISEEVNVSYKEETNEVIINTDAGRARRPLIVVENGEPLLTEEHIE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  83 ALKNGDLDFDDLVERGKVEFIDAEEEEDIYVAVDEDDLSEDHTHLEVDPQLIFGIGAGMVPYPEHNASPRITMGSGMIKQ 162
Cdd:PRK07225   81 KLKNGELTFDDLVKQGVIEYLDAEEEENAYIAVYEEDLTEEHTHLEIDPSLILGIGAGMIPYPEHNASPRITMGAGMIKQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 163 SLGLPAANYRIRPDTRQHLLHYPQLSMVKTQTTEQIGYDDRPAAQNFTVAVMSYEGFNIEDALVLNAGSVDRALARSHFF 242
Cdd:PRK07225  161 SLGLPAANYKLRPDTRGHLLHYPQVPLVKTQTQEIIGFDERPAGQNFVVAVMSYEGYNIEDALIMNKASIERGLGRSHFF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 243 RTYEGEERRYPGGQEDRFEIPSDDVRGARGEDAYTHLDDDGLVNPETRVDESSVLLGKTSPPRFLEEPDDMGgLSPQKRR 322
Cdd:PRK07225  241 RTYEGEERRYPGGQEDRFEIPDKDVRGYRGEEAYRHLDEDGLVNPETEVKEGDVLIGKTSPPRFLEEPDDFG-ISPEKRR 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 323 ETSVTMRSGESGIVDTVTLMEGEDGSKLSKVSVRDERIPELGDKFASRHGQKGVVGHIAPQEDMPFTEQGVVPDLIINPH 402
Cdd:PRK07225  320 ETSVTMRSGEEGIVDTVILTETEEGSRLVKVRVRDLRIPELGDKFASRHGQKGVIGLIVPQEDMPFTESGVVPDLIINPH 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 403 ALPSRMTVGHVLEMIGGKVGALEGRRVDGTPFTGEDEDELRGGLEEQGFKSSGKEIMYSGVTGEKIEAEIFIGTIFYQKL 482
Cdd:PRK07225  400 AIPSRMTVGHVLEMIGGKVGSLEGRRVDGTAFSGEDEEDLREALEKLGFEHTGKEVMYDGITGEKIEAEIFVGVIYYQKL 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 483 YHMVSNKLHARSRGPVQVLTRQPTEGRAREGGLRVGEMERDVLIGHGAALTLKERLLDESDREWIYVCANCGMSAVENVE 562
Cdd:PRK07225  480 HHMVANKLHARSRGPVQVLTRQPTEGRAREGGLRFGEMERDVLIGHGAAMLLKERLLDESDKVEIYVCAKCGMIAIYDKK 559
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*.
gi 1561178664 563 QNRVYCPNCDEETDIHEIEMSYAFKLLLDEMKALGIAPRLELEDAV 608
Cdd:PRK07225  560 RNRKYCPICGEETDIYPVEMSYAFKLLLDELKSLGIAPRLELEDKV 605
rpoB_arch TIGR03670
DNA-directed RNA polymerase subunit B; This model represents the archaeal version of ...
9-608 0e+00

DNA-directed RNA polymerase subunit B; This model represents the archaeal version of DNA-directed RNA polymerase subunit B (rpoB) and is observed in all archaeal genomes.


Pssm-ID: 274713 [Multi-domain]  Cd Length: 599  Bit Score: 1114.33  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664   9 VYVNGSLVGTHPDPEQLAEQVRHARRRGDVSEMVNVSVKERTREVIINADAGRARRPLLVVEDGKPLATEEEVEALKNGD 88
Cdd:TIGR03670   1 VYLNGRLIGYHDDPEELVEEVRKLRRSGKLSQEVNVAYYEETNEVYINCDAGRIRRPLIVVENGKPKLTREHVEKLKEGE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  89 LDFDDLVERGKVEFIDAEEEEDIYVAVDEDDLSEDHTHLEVDPQLIFGIGAGMVPYPEHNASPRITMGSGMIKQSLGLPA 168
Cdd:TIGR03670  81 LTWDDLVKQGVIEYLDAEEEENAYIALDPEELTPEHTHLEIDPSAILGIIASTIPYPEHNQSPRNTMGAAMAKQSLGLYA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 169 ANYRIRPDTRQHLLHYPQLSMVKTQTTEQIGYDDRPAAQNFTVAVMSYEGFNIEDALVLNAGSVDRALARSHFFRTYEGE 248
Cdd:TIGR03670 161 ANYRIRLDTRGHLLHYPQKPLVKTRVLELIGYDDRPAGQNFVVAVMSYEGYNIEDALIMNKASIERGLARSTFFRTYEAE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 249 ERRYPGGQEDRFEIPSDDVRGARGEDAYTHLDDDGLVNPETRVDESSVLLGKTSPPRFLEEPDDMGgLSPQKRRETSVTM 328
Cdd:TIGR03670 241 ERRYPGGQEDRFEIPEPDVRGYRGEEAYKHLDEDGIVYPEVEVKGGDVLIGKTSPPRFLEELREFG-LVTERRRDTSVTV 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 329 RSGESGIVDTVTLMEGEDGSKLSKVSVRDERIPELGDKFASRHGQKGVVGHIAPQEDMPFTEQGVVPDLIINPHALPSRM 408
Cdd:TIGR03670 320 RHGEKGIVDKVIITETEEGNKLVKVRVRDLRIPELGDKFASRHGQKGVIGMIVPQEDMPFTEDGIVPDLIINPHAIPSRM 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 409 TVGHVLEMIGGKVGALEGRRVDGTPFTGEDEDELRGGLEEQGFKSSGKEIMYSGVTGEKIEAEIFIGTIFYQKLYHMVSN 488
Cdd:TIGR03670 400 TVGQLLEMIAGKVAALEGRRVDGTPFEGEPEEELRKELLKLGFKPDGKEVMYDGITGEKLEAEIFIGVIYYQKLHHMVAD 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 489 KLHARSRGPVQVLTRQPTEGRAREGGLRVGEMERDVLIGHGAALTLKERLLDESDREWIYVCANCGMSAVENVEQNRVYC 568
Cdd:TIGR03670 480 KIHARSRGPVQVLTRQPTEGRAREGGLRFGEMERDVLIGHGAAMLLKERLLDESDKYVVYVCENCGHIAWEDKRKGTAYC 559
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|
gi 1561178664 569 PNCDEETDIHEIEMSYAFKLLLDEMKALGIAPRLELEDAV 608
Cdd:TIGR03670 560 PVCGETGDISPVEMSYAFKLLLDELKSLGISPRLELGDKV 599
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
120-603 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 672.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 120 LSEDHTHLEVDPQLIFGIGAGMVPYPEHNASPRITMGSGMIKQSLGLPAANYRIRPDTRQHLLHYPQLSMVKTQTTEQIG 199
Cdd:cd00653   391 VEKEVTHIEISPSQILSVAASLIPFPEHNQSPRNLYQSNMQKQAVGTPALNQQYRMDTKLYLLLYPQKPLVGTGIEEYIA 470
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 200 YDDRPAAQNFTVAVMSYEGFNIEDALVLNAGSVDRALARSHFFRTYEGEERRYPGGQEDRFEIPSDDVRgargEDAYTHL 279
Cdd:cd00653   471 FGELPLGQNAIVAVMSYSGYNFEDAIIINKSSVDRGFFRSIHYKKYEIELRKTKNGPEEITRGDIPNVS----EEKLKNL 546
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 280 DDDGLVNPETRVDESSVLLGKTSPPRFlEEPDDMGGLSPQKRRETSVTMRSGESGIVDTVTLMEGE---DGSKLSKVSVR 356
Cdd:cd00653   547 DEDGIIRPGARVEPGDILVGKITPKGE-TESTPIFGEKARDVRDTSLKYPGGEKGIVDDVKIFSRElndGGNKLVKVYIR 625
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 357 DERIPELGDKFASRHGQKGVVGHIAPQEDMPFTEQGVVPDLIINPHALPSRMTVGHVLEMIGGKVGALEGRRVDGTPFTG 436
Cdd:cd00653   626 QKRKPQIGDKFASRHGQKGVISKILPQEDMPFTEDGIPPDIILNPHGFPSRMTIGQLLESLLGKAGALLGKFGDATPFDG 705
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 437 EDEDELRGGLEEQGFKSSGKEIMYSGVTGEKIEAEIFIGTIFYQKLYHMVSNKLHARSRGPVQVLTRQPTEGRAREGGLR 516
Cdd:cd00653   706 AEEEDISELLGEAGLNYYGKEVLYDGRTGEPLEAPIFVGPVYYQRLKHMVDDKIHARSTGPYSLLTRQPLKGRSRGGGQR 785
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 517 VGEMERDVLIGHGAALTLKERLLDESDREWIYVCANCGMSAVENveqnrvYCPNCDEETDIHEIEMSYAFKLLLDEMKAL 596
Cdd:cd00653   786 FGEMERDALIAHGAAYLLQERLTIKSDDVVARVCVKCGIILSAN------LCRLCKKGTNISKVGIPYAFKLLFQELQSM 859

                  ....*..
gi 1561178664 597 GIAPRLE 603
Cdd:cd00653   860 NIDPRLK 866
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
60-606 0e+00

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 645.63  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664   60 GRARRPLLVVEDGKplATEEevealkngdldfddlvergkVEFIDAEEEEDIYVAVDEDDLSED---------------- 123
Cdd:COG0085    445 GFIETPYRKVENGK--VTDE--------------------IEYLTADEEENYYIAQANAPLDEDgnfleervlvryrgee 502
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  124 -------HTHLEVDPQLIFGIGAGMVPYPEHNASPRITMGSGMIKQSLGLPAANYRirpdtrqhLLHYPQLSMVKT-QTT 195
Cdd:COG0085    503 vlvppeeVDYMDVSPKQIVSVATSLIPFLEHDDANRALMGANMQRQAVPLLRPEAP--------LLHYPLQKFQRSnQGT 574
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  196 -----------EQIG------------YDDRPAAQNFTVAVMSYEGFNIEDALVLNAGSVDRALARSHFFRTYEGEERRY 252
Cdd:COG0085    575 cinqrpivrvgDRVEkgdvladgpatdNGELALGQNLLVAFMPWEGYNYEDAIIISERLVKDDVLTSIHIEEYEIEARDT 654
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  253 PGGQEDR-FEIPSDdvrgarGEDAYTHLDDDGLVNPETRVDESSVLLGKTSPPRFLEEPDDMG------GLSPQKRRETS 325
Cdd:COG0085    655 KLGPEEItRDIPNV------SEEALRNLDEDGIIRIGAEVKGGDILVGKVTPKGETELTPEERllraifGEKAREVRDTS 728
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  326 VTMRSGESGIVDTVTLMEGEDGSKLS-------KVSVRDERIPELGDKFASRHGQKGVVGHIAPQEDMPFTEQGVVPDLI 398
Cdd:COG0085    729 LRVPHGEKGKVIDVKVFSREEGDELPpgvnklvRVYVAQKRKIEVGDKLAGRHGNKGVISRILPQEDMPFLEDGTPVDIV 808
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  399 INPHALPSRMTVGHVLEMIGGKVGALEGRRVDGTPFTGEDEDELRGGLEEQGFKSSGKEIMYSGVTGEKIEAEIFIGTIF 478
Cdd:COG0085    809 LNPLGVPSRMNVGQVLETHLGWAAALLGRRVATPVFDGAPEEEIRELLEKAGLPPDGKEVLYDGRTGEPFDNPVTVGYMY 888
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  479 YQKLYHMVSNKLHARSRGPVQVLTRQPTEGRAREGGLRVGEMERDVLIGHGAALTLKERLLDESDRewiyvcaNCGMSAV 558
Cdd:COG0085    889 YLKLHHMVDDKIHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQERLTIKSDD-------VCGRVKV 961
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*...
gi 1561178664  559 ENveqNRVycpncdEETDIHEIEMSYAFKLLLDEMKALGIAPRLELED 606
Cdd:COG0085    962 YE---AIV------KGENIPEPGIPESFKVLLKELQSLGLDVEVLSED 1000
RNA_pol_Rpb2_6 pfam00562
RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of ...
139-511 1.18e-178

RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion. This domain is also involved in binding to Rpb1 and Rpb3. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).


Pssm-ID: 459854 [Multi-domain]  Cd Length: 371  Bit Score: 510.15  E-value: 1.18e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 139 AGMVPYPEHNASPRITMGSGMIKQSLGLPAANYRIRPDTRQHLLHYPQLSMVKTQTTEQIGYDDRPAAQNFTVAVMSYEG 218
Cdd:pfam00562   2 ASLIPFVDHNQSPRNTYQCAMGKQAMGIYTLNKFYRSDQNTYVLCYPQKPLVKTGAVEAGGFGELPLGQNAIVAVMSYTG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 219 FNIEDALVLNAGSVDRALARSHFFRTYEgeERRYPGGQ-EDRFEIPSDDvrgarGEDAYTHLDDDGLVNPETRVDESSVL 297
Cdd:pfam00562  82 YNQEDAIIINKSSVDRGFFTSIHIKEIE--ARKTKLGPiEEITRDIPNV-----SEEALKKLDEDGIVRVGAEVKPGDIL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 298 LGKTSPPRFLEEPDDMGGLSPQKRRETSVTMRSGESGIVDTVTLME-GEDGSKLSKVSVRDERIPELGDKFASRHGQKGV 376
Cdd:pfam00562 155 VGKVGPTELTKLLRAIFGEKARDVKDTSLKVPPGEEGVVDDVIVFElPPGGIKMVKVYIRQKRKPEVGDKFASRHGQKGV 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 377 VGHIAPQEDMPFTEQGVVPDLIINPHALPSRMTVGHVLEMIGGKVGALEGRRVDGTPFTGEDE--DELRGGLEEQGFKSS 454
Cdd:pfam00562 235 VSRILPQEDMPFTEDGIPPDIILNPHGVPSRMTIGQLLETHLGKAAALLGVFVDATPFDGASTevEDIGELLEKAGYNYY 314
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1561178664 455 GKEIMYSGVTGEKIEAEIFIGTIFYQKLYHMVSNKLHARSRGPVQVLTRQPTEGRAR 511
Cdd:pfam00562 315 GKEVLYDGRTGEPFEAPIFVGPIYYQKLKHMVDDKIHARSTGPYSLLTRQPLGGRAR 371
 
Name Accession Description Interval E-value
PRK07225 PRK07225
DNA-directed RNA polymerase subunit B'; Validated
3-608 0e+00

DNA-directed RNA polymerase subunit B'; Validated


Pssm-ID: 235972 [Multi-domain]  Cd Length: 605  Bit Score: 1274.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664   3 QGREAKVYVNGSLVGTHPDPEQLAEQVRHARRRGDVSEMVNVSVKERTREVIINADAGRARRPLLVVEDGKPLATEEEVE 82
Cdd:PRK07225    1 MMRKAKVYVNGKLIGTHDDPEELVEEIREARRSGEISEEVNVSYKEETNEVIINTDAGRARRPLIVVENGEPLLTEEHIE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  83 ALKNGDLDFDDLVERGKVEFIDAEEEEDIYVAVDEDDLSEDHTHLEVDPQLIFGIGAGMVPYPEHNASPRITMGSGMIKQ 162
Cdd:PRK07225   81 KLKNGELTFDDLVKQGVIEYLDAEEEENAYIAVYEEDLTEEHTHLEIDPSLILGIGAGMIPYPEHNASPRITMGAGMIKQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 163 SLGLPAANYRIRPDTRQHLLHYPQLSMVKTQTTEQIGYDDRPAAQNFTVAVMSYEGFNIEDALVLNAGSVDRALARSHFF 242
Cdd:PRK07225  161 SLGLPAANYKLRPDTRGHLLHYPQVPLVKTQTQEIIGFDERPAGQNFVVAVMSYEGYNIEDALIMNKASIERGLGRSHFF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 243 RTYEGEERRYPGGQEDRFEIPSDDVRGARGEDAYTHLDDDGLVNPETRVDESSVLLGKTSPPRFLEEPDDMGgLSPQKRR 322
Cdd:PRK07225  241 RTYEGEERRYPGGQEDRFEIPDKDVRGYRGEEAYRHLDEDGLVNPETEVKEGDVLIGKTSPPRFLEEPDDFG-ISPEKRR 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 323 ETSVTMRSGESGIVDTVTLMEGEDGSKLSKVSVRDERIPELGDKFASRHGQKGVVGHIAPQEDMPFTEQGVVPDLIINPH 402
Cdd:PRK07225  320 ETSVTMRSGEEGIVDTVILTETEEGSRLVKVRVRDLRIPELGDKFASRHGQKGVIGLIVPQEDMPFTESGVVPDLIINPH 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 403 ALPSRMTVGHVLEMIGGKVGALEGRRVDGTPFTGEDEDELRGGLEEQGFKSSGKEIMYSGVTGEKIEAEIFIGTIFYQKL 482
Cdd:PRK07225  400 AIPSRMTVGHVLEMIGGKVGSLEGRRVDGTAFSGEDEEDLREALEKLGFEHTGKEVMYDGITGEKIEAEIFVGVIYYQKL 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 483 YHMVSNKLHARSRGPVQVLTRQPTEGRAREGGLRVGEMERDVLIGHGAALTLKERLLDESDREWIYVCANCGMSAVENVE 562
Cdd:PRK07225  480 HHMVANKLHARSRGPVQVLTRQPTEGRAREGGLRFGEMERDVLIGHGAAMLLKERLLDESDKVEIYVCAKCGMIAIYDKK 559
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*.
gi 1561178664 563 QNRVYCPNCDEETDIHEIEMSYAFKLLLDEMKALGIAPRLELEDAV 608
Cdd:PRK07225  560 RNRKYCPICGEETDIYPVEMSYAFKLLLDELKSLGIAPRLELEDKV 605
rpoB_arch TIGR03670
DNA-directed RNA polymerase subunit B; This model represents the archaeal version of ...
9-608 0e+00

DNA-directed RNA polymerase subunit B; This model represents the archaeal version of DNA-directed RNA polymerase subunit B (rpoB) and is observed in all archaeal genomes.


Pssm-ID: 274713 [Multi-domain]  Cd Length: 599  Bit Score: 1114.33  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664   9 VYVNGSLVGTHPDPEQLAEQVRHARRRGDVSEMVNVSVKERTREVIINADAGRARRPLLVVEDGKPLATEEEVEALKNGD 88
Cdd:TIGR03670   1 VYLNGRLIGYHDDPEELVEEVRKLRRSGKLSQEVNVAYYEETNEVYINCDAGRIRRPLIVVENGKPKLTREHVEKLKEGE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  89 LDFDDLVERGKVEFIDAEEEEDIYVAVDEDDLSEDHTHLEVDPQLIFGIGAGMVPYPEHNASPRITMGSGMIKQSLGLPA 168
Cdd:TIGR03670  81 LTWDDLVKQGVIEYLDAEEEENAYIALDPEELTPEHTHLEIDPSAILGIIASTIPYPEHNQSPRNTMGAAMAKQSLGLYA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 169 ANYRIRPDTRQHLLHYPQLSMVKTQTTEQIGYDDRPAAQNFTVAVMSYEGFNIEDALVLNAGSVDRALARSHFFRTYEGE 248
Cdd:TIGR03670 161 ANYRIRLDTRGHLLHYPQKPLVKTRVLELIGYDDRPAGQNFVVAVMSYEGYNIEDALIMNKASIERGLARSTFFRTYEAE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 249 ERRYPGGQEDRFEIPSDDVRGARGEDAYTHLDDDGLVNPETRVDESSVLLGKTSPPRFLEEPDDMGgLSPQKRRETSVTM 328
Cdd:TIGR03670 241 ERRYPGGQEDRFEIPEPDVRGYRGEEAYKHLDEDGIVYPEVEVKGGDVLIGKTSPPRFLEELREFG-LVTERRRDTSVTV 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 329 RSGESGIVDTVTLMEGEDGSKLSKVSVRDERIPELGDKFASRHGQKGVVGHIAPQEDMPFTEQGVVPDLIINPHALPSRM 408
Cdd:TIGR03670 320 RHGEKGIVDKVIITETEEGNKLVKVRVRDLRIPELGDKFASRHGQKGVIGMIVPQEDMPFTEDGIVPDLIINPHAIPSRM 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 409 TVGHVLEMIGGKVGALEGRRVDGTPFTGEDEDELRGGLEEQGFKSSGKEIMYSGVTGEKIEAEIFIGTIFYQKLYHMVSN 488
Cdd:TIGR03670 400 TVGQLLEMIAGKVAALEGRRVDGTPFEGEPEEELRKELLKLGFKPDGKEVMYDGITGEKLEAEIFIGVIYYQKLHHMVAD 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 489 KLHARSRGPVQVLTRQPTEGRAREGGLRVGEMERDVLIGHGAALTLKERLLDESDREWIYVCANCGMSAVENVEQNRVYC 568
Cdd:TIGR03670 480 KIHARSRGPVQVLTRQPTEGRAREGGLRFGEMERDVLIGHGAAMLLKERLLDESDKYVVYVCENCGHIAWEDKRKGTAYC 559
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|
gi 1561178664 569 PNCDEETDIHEIEMSYAFKLLLDEMKALGIAPRLELEDAV 608
Cdd:TIGR03670 560 PVCGETGDISPVEMSYAFKLLLDELKSLGISPRLELGDKV 599
PRK08565 PRK08565
DNA-directed RNA polymerase subunit B; Provisional
7-608 0e+00

DNA-directed RNA polymerase subunit B; Provisional


Pssm-ID: 236291 [Multi-domain]  Cd Length: 1103  Bit Score: 1037.61  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664    7 AKVYVNGSLVGTHPDPEQLAEQVRHARRRGDVSEMVNVSV--KERTREVIINADAGRARRPLLVVEDGKPLATEEEVEAL 84
Cdd:PRK08565   501 SRVYLNGRLIGYHPDGEELAEKIRELRRSGKISDEVNVAYieTGEINEVYVNCDSGRVRRPLIVVENGKPKLTREHVEKL 580
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664   85 KNGDLDFDDLVERGKVEFIDAEEEEDIYVAVDEDDLSEDHTHLEVDPQLIFGIGAGMVPYPEHNASPRITMGSGMIKQSL 164
Cdd:PRK08565   581 KKGELTFDDLVKMGVIEYLDAEEEENAYVALDPEDLTPEHTHLEIWPPAILGITASIIPYPEHNQSPRNTYQAAMAKQSL 660
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  165 GLPAANYRIRPDTRQHLLHYPQLSMVKTQTTEQIGYDDRPAAQNFTVAVMSYEGFNIEDALVLNAGSVDRALARSHFFRT 244
Cdd:PRK08565   661 GLYAANFRIRTDTRGHLLHYPQRPLVQTRALEIIGYNDRPAGQNAVVAVLSYTGYNIEDAIIMNKASIERGLARSTFFRT 740
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  245 YEGEERRYPGGQEDRFEIPSDDVRGARGEDAYTHLDDDGLVNPETRVDESSVLLGKTSPPRFLEEPDDMGGLsPQKRRET 324
Cdd:PRK08565   741 YETEERKYPGGQEDKIEIPEPNVRGYRGEEYYRKLDEDGIVSPEVEVKGGDVLIGKTSPPRFLEELEELSLG-LQERRDT 819
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  325 SVTMRSGESGIVDTVTLMEGEDGSKLSKVSVRDERIPELGDKFASRHGQKGVVGHIAPQEDMPFTEQGVVPDLIINPHAL 404
Cdd:PRK08565   820 SVTVRHGEKGIVDTVLITESPEGNKLVKVRVRDLRIPELGDKFASRHGQKGVIGMLVPQEDMPFTEDGIVPDLIINPHAI 899
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  405 PSRMTVGHVLEMIGGKVGALEGRRVDGTPFTGEDEDELRGGLEEQGFKSSGKEIMYSGVTGEKIEAEIFIGTIFYQKLYH 484
Cdd:PRK08565   900 PSRMTVGQLLESIAGKVAALEGRFVDATPFYGEPEEELRKELLKLGYKPDGTEVMYDGRTGEKIKAPIFIGVVYYQKLHH 979
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  485 MVSNKLHARSRGPVQVLTRQPTEGRAREGGLRVGEMERDVLIGHGAALTLKERLLDESDREWIYVCANCGMSAVENVEQN 564
Cdd:PRK08565   980 MVADKIHARARGPVQILTRQPTEGRAREGGLRFGEMERDCLIGHGAAMLLKERLLDSSDKTTIYVCELCGHIAWYDRRKN 1059
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....
gi 1561178664  565 RVYCPNCDEETDIHEIEMSYAFKLLLDEMKALGIAPRLELEDAV 608
Cdd:PRK08565  1060 KYVCPIHGDKGNISPVEVSYAFKLLLQELMSMGISPRLKLGDKV 1103
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
120-603 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 672.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 120 LSEDHTHLEVDPQLIFGIGAGMVPYPEHNASPRITMGSGMIKQSLGLPAANYRIRPDTRQHLLHYPQLSMVKTQTTEQIG 199
Cdd:cd00653   391 VEKEVTHIEISPSQILSVAASLIPFPEHNQSPRNLYQSNMQKQAVGTPALNQQYRMDTKLYLLLYPQKPLVGTGIEEYIA 470
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 200 YDDRPAAQNFTVAVMSYEGFNIEDALVLNAGSVDRALARSHFFRTYEGEERRYPGGQEDRFEIPSDDVRgargEDAYTHL 279
Cdd:cd00653   471 FGELPLGQNAIVAVMSYSGYNFEDAIIINKSSVDRGFFRSIHYKKYEIELRKTKNGPEEITRGDIPNVS----EEKLKNL 546
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 280 DDDGLVNPETRVDESSVLLGKTSPPRFlEEPDDMGGLSPQKRRETSVTMRSGESGIVDTVTLMEGE---DGSKLSKVSVR 356
Cdd:cd00653   547 DEDGIIRPGARVEPGDILVGKITPKGE-TESTPIFGEKARDVRDTSLKYPGGEKGIVDDVKIFSRElndGGNKLVKVYIR 625
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 357 DERIPELGDKFASRHGQKGVVGHIAPQEDMPFTEQGVVPDLIINPHALPSRMTVGHVLEMIGGKVGALEGRRVDGTPFTG 436
Cdd:cd00653   626 QKRKPQIGDKFASRHGQKGVISKILPQEDMPFTEDGIPPDIILNPHGFPSRMTIGQLLESLLGKAGALLGKFGDATPFDG 705
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 437 EDEDELRGGLEEQGFKSSGKEIMYSGVTGEKIEAEIFIGTIFYQKLYHMVSNKLHARSRGPVQVLTRQPTEGRAREGGLR 516
Cdd:cd00653   706 AEEEDISELLGEAGLNYYGKEVLYDGRTGEPLEAPIFVGPVYYQRLKHMVDDKIHARSTGPYSLLTRQPLKGRSRGGGQR 785
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 517 VGEMERDVLIGHGAALTLKERLLDESDREWIYVCANCGMSAVENveqnrvYCPNCDEETDIHEIEMSYAFKLLLDEMKAL 596
Cdd:cd00653   786 FGEMERDALIAHGAAYLLQERLTIKSDDVVARVCVKCGIILSAN------LCRLCKKGTNISKVGIPYAFKLLFQELQSM 859

                  ....*..
gi 1561178664 597 GIAPRLE 603
Cdd:cd00653   860 NIDPRLK 866
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
60-606 0e+00

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 645.63  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664   60 GRARRPLLVVEDGKplATEEevealkngdldfddlvergkVEFIDAEEEEDIYVAVDEDDLSED---------------- 123
Cdd:COG0085    445 GFIETPYRKVENGK--VTDE--------------------IEYLTADEEENYYIAQANAPLDEDgnfleervlvryrgee 502
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  124 -------HTHLEVDPQLIFGIGAGMVPYPEHNASPRITMGSGMIKQSLGLPAANYRirpdtrqhLLHYPQLSMVKT-QTT 195
Cdd:COG0085    503 vlvppeeVDYMDVSPKQIVSVATSLIPFLEHDDANRALMGANMQRQAVPLLRPEAP--------LLHYPLQKFQRSnQGT 574
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  196 -----------EQIG------------YDDRPAAQNFTVAVMSYEGFNIEDALVLNAGSVDRALARSHFFRTYEGEERRY 252
Cdd:COG0085    575 cinqrpivrvgDRVEkgdvladgpatdNGELALGQNLLVAFMPWEGYNYEDAIIISERLVKDDVLTSIHIEEYEIEARDT 654
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  253 PGGQEDR-FEIPSDdvrgarGEDAYTHLDDDGLVNPETRVDESSVLLGKTSPPRFLEEPDDMG------GLSPQKRRETS 325
Cdd:COG0085    655 KLGPEEItRDIPNV------SEEALRNLDEDGIIRIGAEVKGGDILVGKVTPKGETELTPEERllraifGEKAREVRDTS 728
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  326 VTMRSGESGIVDTVTLMEGEDGSKLS-------KVSVRDERIPELGDKFASRHGQKGVVGHIAPQEDMPFTEQGVVPDLI 398
Cdd:COG0085    729 LRVPHGEKGKVIDVKVFSREEGDELPpgvnklvRVYVAQKRKIEVGDKLAGRHGNKGVISRILPQEDMPFLEDGTPVDIV 808
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  399 INPHALPSRMTVGHVLEMIGGKVGALEGRRVDGTPFTGEDEDELRGGLEEQGFKSSGKEIMYSGVTGEKIEAEIFIGTIF 478
Cdd:COG0085    809 LNPLGVPSRMNVGQVLETHLGWAAALLGRRVATPVFDGAPEEEIRELLEKAGLPPDGKEVLYDGRTGEPFDNPVTVGYMY 888
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  479 YQKLYHMVSNKLHARSRGPVQVLTRQPTEGRAREGGLRVGEMERDVLIGHGAALTLKERLLDESDRewiyvcaNCGMSAV 558
Cdd:COG0085    889 YLKLHHMVDDKIHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQERLTIKSDD-------VCGRVKV 961
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*...
gi 1561178664  559 ENveqNRVycpncdEETDIHEIEMSYAFKLLLDEMKALGIAPRLELED 606
Cdd:COG0085    962 YE---AIV------KGENIPEPGIPESFKVLLKELQSLGLDVEVLSED 1000
RNA_pol_Rpb2_6 pfam00562
RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of ...
139-511 1.18e-178

RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion. This domain is also involved in binding to Rpb1 and Rpb3. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).


Pssm-ID: 459854 [Multi-domain]  Cd Length: 371  Bit Score: 510.15  E-value: 1.18e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 139 AGMVPYPEHNASPRITMGSGMIKQSLGLPAANYRIRPDTRQHLLHYPQLSMVKTQTTEQIGYDDRPAAQNFTVAVMSYEG 218
Cdd:pfam00562   2 ASLIPFVDHNQSPRNTYQCAMGKQAMGIYTLNKFYRSDQNTYVLCYPQKPLVKTGAVEAGGFGELPLGQNAIVAVMSYTG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 219 FNIEDALVLNAGSVDRALARSHFFRTYEgeERRYPGGQ-EDRFEIPSDDvrgarGEDAYTHLDDDGLVNPETRVDESSVL 297
Cdd:pfam00562  82 YNQEDAIIINKSSVDRGFFTSIHIKEIE--ARKTKLGPiEEITRDIPNV-----SEEALKKLDEDGIVRVGAEVKPGDIL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 298 LGKTSPPRFLEEPDDMGGLSPQKRRETSVTMRSGESGIVDTVTLME-GEDGSKLSKVSVRDERIPELGDKFASRHGQKGV 376
Cdd:pfam00562 155 VGKVGPTELTKLLRAIFGEKARDVKDTSLKVPPGEEGVVDDVIVFElPPGGIKMVKVYIRQKRKPEVGDKFASRHGQKGV 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 377 VGHIAPQEDMPFTEQGVVPDLIINPHALPSRMTVGHVLEMIGGKVGALEGRRVDGTPFTGEDE--DELRGGLEEQGFKSS 454
Cdd:pfam00562 235 VSRILPQEDMPFTEDGIPPDIILNPHGVPSRMTIGQLLETHLGKAAALLGVFVDATPFDGASTevEDIGELLEKAGYNYY 314
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1561178664 455 GKEIMYSGVTGEKIEAEIFIGTIFYQKLYHMVSNKLHARSRGPVQVLTRQPTEGRAR 511
Cdd:pfam00562 315 GKEVLYDGRTGEPFEAPIFVGPIYYQKLKHMVDDKIHARSTGPYSLLTRQPLGGRAR 371
rpoB TIGR02013
DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit ...
85-598 1.31e-70

DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit of Bacterial RNA polymerase. The core enzyme consists of two alpha chains, one beta chain, and one beta' subunit. [Transcription, DNA-dependent RNA polymerase]


Pssm-ID: 273928 [Multi-domain]  Cd Length: 1065  Bit Score: 246.88  E-value: 1.31e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664   85 KNGDLDFDDlvergKVEFIDAEEEEDIYVA-----VDEDD-LSEDH-----------------THLEVDPQLIFGIGAGM 141
Cdd:TIGR02013  471 KDGKVVVTD-----EIDYLTADEEDNYVIAqanapLDENGrFVEDLvvaryrgeitlvspdqvDYMDVSPKQVVSVAASL 545
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  142 VPYPEHNASPRITMGSGMIKQSLGL-----------------------------------PAANYRIRPDTRQHLLHYPQ 186
Cdd:TIGR02013  546 IPFLEHDDANRALMGSNMQRQAVPLlrseaplvgtgmeakvardsgavivakrggvveyvDAKRIVIRYDEDEEEPDGGI 625
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  187 L--SMVKTQTTEQ-IGYDDRPA--------------------------AQNFTVAVMSYEGFNIEDALVLNAGSVDRALA 237
Cdd:TIGR02013  626 DiyRLLKYQRSNQdTCINQRPIvsvgdrveagdvladgpstdlgelalGRNVLVAFMPWNGYNYEDAILISERLVKDDVF 705
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  238 RSHFFRTYEGEERRYPGGQEdrfEIPSD--DVrgarGEDAYTHLDDDGLVNPETRVDESSVLLGKTSPPRFLEepddmgg 315
Cdd:TIGR02013  706 TSIHIEEYEVEARDTKLGPE---EITRDipNV----SEEALRNLDENGIVRIGAEVKAGDILVGKVTPKGETE------- 771
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  316 LSPQKR-------------RETSVTMRSGESGIVDTVTLMEGEDG-------SKLSKVSVRDERIPELGDKFASRHGQKG 375
Cdd:TIGR02013  772 LTPEEKllraifgekardvRDTSLRVPPGVEGTVIDVKVFSREQGdelppgvNKLVKVYIAQKRKIQVGDKMAGRHGNKG 851
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  376 VVGHIAPQEDMPFTEQGVVPDLIINPHALPSRMTVGHVLEMIGGKVGALEGRRVD--GTP-FTGEDEDELRGGLEEQGFK 452
Cdd:TIGR02013  852 VVSKILPIEDMPFLEDGTPVDIVLNPLGVPSRMNIGQILETHLGWAGKRLGRKGVpiATPvFDGASEEEIKEYLEKAGLP 931
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  453 SSGKEIMYSGVTGEKIEAEIFIGTIFYQKLYHMVSNKLHARSRGPVQVLTRQPTEGRAREGGLRVGEMERDVLIGHGAAL 532
Cdd:TIGR02013  932 RDGKVRLYDGRTGEQFDRPVTVGYMYMLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAY 1011
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  533 TLKERLLDESD----REWIYVCANCGmsavENVeqnrvycpncdEETDIHEiemsyAFKLLLDEMKALGI 598
Cdd:TIGR02013 1012 TLQEMLTVKSDdvvgRTKAYEAIVKG----ENV-----------PEPGIPE-----SFNVLIKELQSLGL 1061
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
207-607 2.63e-58

DNA-directed RNA polymerase subunit beta; Reviewed


Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 211.50  E-value: 2.63e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  207 QNFTVAVMSYEGFNIEDALVLNagsvDRaLARSHFFRT-----YEGEERRYPGGQEdrfEIPSD--DVrgarGEDAYTHL 279
Cdd:PRK00405   717 QNVLVAFMPWNGYNFEDAILIS----ER-LVKEDVFTSihieeYEIEARDTKLGPE---EITRDipNV----SEEALRNL 784
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  280 DDDGLVNPETRVDESSVLLGKTSPPRflEEPddmggLSPQKR-------------RETSVTMRSGESGIV-DTVTLMEGE 345
Cdd:PRK00405   785 DESGIVRIGAEVKPGDILVGKVTPKG--ETE-----LTPEEKllraifgekardvKDTSLRVPHGEEGTViDVKVFTRIE 857
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  346 DGS-------KLSKVSVRDERIPELGDKFASRHGQKGVVGHIAPQEDMPFTEQGVVPDLIINPHALPSRMTVGHVLEMIG 418
Cdd:PRK00405   858 QGDelppgvnKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSRILPVEDMPYLEDGTPVDIVLNPLGVPSRMNIGQILETHL 937
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  419 GKVGALEGRRVdGTP-FTGEDEDELRGGLEEQGFKSSGKEIMYSGVTGEKIEAEIFIGTIFYQKLYHMVSNKLHARSRGP 497
Cdd:PRK00405   938 GWAAKGLGIKF-ATPvFDGAKEEEIKELLEEAGLPEDGKTTLYDGRTGEPFDRPVTVGYMYMLKLHHLVDDKIHARSTGP 1016
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  498 VQVLTRQPTEGRAREGGLRVGEMERDVLIGHGAALTLKERLLDESDrewiyvcancgmsaveNVE-QNRVYcpncdeE-- 574
Cdd:PRK00405  1017 YSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSD----------------DVVgRTKVY------Eai 1074
                          410       420       430
                   ....*....|....*....|....*....|....*.
gi 1561178664  575 ---TDIHEIEMSYAFKLLLDEMKALGIAprLELEDA 607
Cdd:PRK00405  1075 vkgENIPEPGIPESFNVLVKELQSLGLD--VELLDE 1108
rpoB CHL00207
RNA polymerase beta subunit; Provisional
207-598 1.39e-53

RNA polymerase beta subunit; Provisional


Pssm-ID: 214397 [Multi-domain]  Cd Length: 1077  Bit Score: 197.62  E-value: 1.39e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  207 QNFTVAVMSYEGFNIEDALVLNAGSVDRALARSHFFRTYEGEERRYPGGQED-RFEIPSddvrgaRGEDAYTHLDDDGLV 285
Cdd:CHL00207   648 QNVLVAYMPWEGYNFEDAILINKRLVYEDLFTSIHIEKYEIELRQTKLGSEEiTRNIPN------VSEYSLKNLDENGII 721
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  286 NPETRVDESSVLLGKTSPPRFLEEPDD------MGGLSPQKRRETSVTMRSGESG-IVDTVTLMEgEDGSKLS------- 351
Cdd:CHL00207   722 SIGSKVLAGDILVGKITPKGESDQLPEgkllraIFGEKAKDVKDTSLRMPNGGYGrVIKVEIFSR-SKGDELKfgyylki 800
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  352 KVSVRDERIPELGDKFASRHGQKGVVGHIAPQEDMPFTEQGVVPDLIINPHALPSRMTVGHVLEMIGGKVGALEGRRVDG 431
Cdd:CHL00207   801 RVFIAQIRKIQVGDKLAGRHGNKGIISRILPRQDMPYLPDGTPPDIILNPLGVPSRMNVGQLFECLLGLAGDNLNKRFKI 880
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  432 TPFTGEDEDE---------LRGGLEEQGFK------SSGKEIMYSGVTGEKIEAEIFIGTIFYQKLYHMVSNKLHARSRG 496
Cdd:CHL00207   881 LPFDEMYGSEysrilinnkLNQASIKNNEYwlfnsyHPGKMVLRDGRTGYKFKNPVTVGIAYMLKLIHLVDDKIHARTTG 960
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  497 PVQVLTRQPTEGRAREGGLRVGEMERDVLIGHGAALTLKERLLDESDrewIYVCANCGMSAVENVEQnrvycpncdeetd 576
Cdd:CHL00207   961 PYSLVTQQPLGGKAQHGGQRFGEMEVWALEAFGAAYTLKELLTIKSD---DMQGRNETLNAIVKGQP------------- 1024
                          410       420
                   ....*....|....*....|..
gi 1561178664  577 IHEIEMSYAFKLLLDEMKALGI 598
Cdd:CHL00207  1025 IPKPGTPESFKVLMRELQSLGL 1046
rpoB CHL00001
RNA polymerase beta subunit
207-543 8.58e-48

RNA polymerase beta subunit


Pssm-ID: 214330 [Multi-domain]  Cd Length: 1070  Bit Score: 180.48  E-value: 8.58e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  207 QNFTVAVMSYEGFNIEDALVLNAGSVDRALARSHFFRTYEGEERRYPGGQEdRF--EIPSDDVRGARgedaytHLDDDGL 284
Cdd:CHL00001   653 KNVLVAYMPWEGYNFEDAVLISERLVYEDIYTSFHIRKYEIQTHVTSQGPE-RItkEIPHLEAHLLR------NLDKNGI 725
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  285 VNPETRVDESSVLLGKTSP---PRFLEEPDD-----MGGLSPQKRRETSVTMRSGESGIVDTVTLMEGEDGSKLSKVSVR 356
Cdd:CHL00001   726 VMLGSWVETGDILVGKLTPqeaEESSYAPEGrllraIFGIQVSTSKETCLKLPIGGRGRVIDVRWIQKKGGSSYNPETIH 805
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  357 ----DERIPELGDKFASRHGQKGVVGHIAPQEDMPFTEQGVVPDLIINPHALPSRMTVGHVLEMIGGKVGALEGRRVDGT 432
Cdd:CHL00001   806 vyilQKREIQVGDKVAGRHGNKGIISKILPRQDMPYLQDGTPVDMVLNPLGVPSRMNVGQIFECLLGLAGDLLNRHYRIA 885
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  433 PFTGEDEDEL-RGGLEEQGFKSS--------------GKEIMYSGVTGEKIEAEIFIGTIFYQKLYHMVSNKLHARSRGP 497
Cdd:CHL00001   886 PFDERYEQEAsRKLVFSELYEASkqtanpwvfepeypGKSRLFDGRTGDPFEQPVTIGKAYILKLIHQVDDKIHARSSGP 965
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1561178664  498 VQVLTRQPTEGRAREGGLRVGEMERDVLIGHGAALTLKERLLDESD 543
Cdd:CHL00001   966 YALVTQQPLRGRSKQGGQRVGEMEVWALEGFGVAYILQEMLTYKSD 1011
RNA_pol_Rpb2_7 pfam04560
RNA polymerase Rpb2, domain 7; RNA polymerases catalyze the DNA dependent polymerization of ...
513-605 3.57e-38

RNA polymerase Rpb2, domain 7; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain comprised of the structural domains anchor and clamp. The clamp region (C-terminal) contains a zinc-binding motif. The clamp region is named due to its interaction with the clamp domain found in Rpb1. The domain also contains a region termed "switch 4". The switches within the polymerase are thought to signal different stages of transcription.


Pssm-ID: 461355 [Multi-domain]  Cd Length: 87  Bit Score: 135.79  E-value: 3.57e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664 513 GGLRVGEMERDVLIGHGAALTLKERLLDESDREWIYVCANCGMSAVENveqnrvYCPNCDEETDIHEIEMSYAFKLLLDE 592
Cdd:pfam04560   1 GGLRFGEMERWALIAYGAAHTLQERLTIKSDAYEVDVCGRCGLYAAYN------KCPICKGETDISPGYIPESFKLLFQE 74
                          90
                  ....*....|...
gi 1561178664 593 MKALGIAPRLELE 605
Cdd:pfam04560  75 LQSLGIDPRLLLE 87
PRK09603 PRK09603
DNA-directed RNA polymerase subunit beta/beta';
95-543 2.33e-34

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 181983 [Multi-domain]  Cd Length: 2890  Bit Score: 140.06  E-value: 2.33e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664   95 VERGKVE----FIDAEEEEDIYVA-----VDEDD----------------LSEDH--THLEVDPQLIFGIGAGMVPYPEH 147
Cdd:PRK09603   608 VVDGKVVgetiYLTAIQEDSHIIApastpIDEEGnilgdlietrvegeivLNEKSkvTLMDLSSSMLVGVAASLIPFLEH 687
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  148 NASPRITMGSGMIKQSLGL-----------------------------------PAANYRI--RPDTRQHLLHYP----- 185
Cdd:PRK09603   688 DDANRALMGTNMQRQAVPLlrsdapivgtgiekiiardswgaikanragvvekiDSKNIYIlgEGKEEAYIDAYSlqknl 767
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  186 ---------QLSMVKTQTTEQIG--YDDRPA--------AQNFTVAVMSYEGFNIEDALVLNAGSV-DRALARSHFFRTy 245
Cdd:PRK09603   768 rtnqntsfnQVPIVKVGDKVEAGqiIADGPSmdrgelalGKNVRVAFMPWNGYNFEDAIVVSERITkDDIFTSTHIYEK- 846
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  246 EGEERRYPGGQEdrfEIPSD--DVRgargEDAYTHLDDDGLVNPETRVDESSVLLGKTSP-------------------- 303
Cdd:PRK09603   847 EVDARELKHGVE---EFTADipDVK----EEALAHLDESGIVKVGTYVSAGMILVGKTSPkgeikstpeerllraifgdk 919
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  304 ------------PRF-----------------------------------------------------------LEEPDD 312
Cdd:PRK09603   920 aghvvnkslycpPSLegtvidvkvftkkgyekdarvlsayeeekakldmehfdrltmlnreellrvssllsqaiLEEPFS 999
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  313 MGGLSPQK-----RRETSVTMRSGESGIV------------------------------DTVTLMEGED-----GSKLSK 352
Cdd:PRK09603  1000 HNGKDYKEgdqipKEEIASINRFTLASLVkkyskevqnhyeitknnfleqkkvlgeeheEKLSILEKDDilpngVIKKVK 1079
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  353 VSVRDERIPELGDKFASRHGQKGVVGHIAPQEDMPFTEQGVVPDLIINPHALPSRMTVGHVLEMIGGKVGALEGRRV--- 429
Cdd:PRK09603  1080 LYIATKRKLKVGDKMAGRHGNKGIVSNIVPVADMPYTADGEPVDIVLNPLGVPSRMNIGQILEMHLGLVGKEFGKQIasm 1159
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  430 ---DGTPFTGE--------------------------DEDELRG-----------------GLEEQGF---------KSS 454
Cdd:PRK09603  1160 ledKTKDFAKElrakmleianainekdpltihalencSDEELLEyakdwskgvkmaipvfeGISQEKFyklfelakiAMD 1239
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  455 GKEIMYSGVTGEKIEAEIFIGTIFYQKLYHMVSNKLHARSRGPVQVLTRQPTEGRAREGGLRVGEMERDVLIGHGAALTL 534
Cdd:PRK09603  1240 GKMDLYDGRTGEKMRERVNVGYMYMIKLHHLVDEKVHARSTGPYSLVTHQPVGGKALFGGQRFGEMEVWALEAYGAAHTL 1319

                   ....*....
gi 1561178664  535 KERLLDESD 543
Cdd:PRK09603  1320 KEMLTIKSD 1328
PRK14844 PRK14844
DNA-directed RNA polymerase subunit beta/beta';
112-543 1.65e-27

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 173305 [Multi-domain]  Cd Length: 2836  Bit Score: 118.96  E-value: 1.65e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  112 YVAVDEDDLSedhtHLEVDPQLIFGIGAGMVPYPEHNASPRITMGSGMIKQSLGL--PAAN------------------- 170
Cdd:PRK14844   663 FVMVSSDQVS----YIDVSPKQVISVAASLIPFLENDDANRALMGSNMQRQAVPLlkPTAPlvatgmesfvasgsgavvl 738
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  171 --------------------------------YRIRPDTRQH---LLHYPQLSMVKTQTTEQIGYDDRPA--------AQ 207
Cdd:PRK14844   739 akrdgivdssdsnsivirafdkervnyldvdiYHLRKFQRSNhntCINQKPLVCVGDYVKEGDVIADGPAinsgelalGQ 818
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  208 NFTVAVMSYEGFNIEDALVLNAGSVDRALARSHFFRTYEGEERRYPGGQEDrfeiPSDDVRGARGEDAYtHLDDDGLVNP 287
Cdd:PRK14844   819 NLLVAFMSWQGYNFEDSIIISSEVVKKDLFTSIHIEEFECVVHDTPLGSEK----ITRAIPGVNEENLY-HLDDSGIVKI 893
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  288 ETRVDESSVLLGKTSPPRFLEEPDDMGGL------------------SP------------------------------- 318
Cdd:PRK14844   894 GTRVGPGYILVGKVTPKPSLSLPPETKLLmtifgeksfdcadsslytSPdvegtvidvqvftrrgveenerallikqkei 973
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  319 -------------------------------QKRRETSVTMRSGESGI----------VDTVT----------------- 340
Cdd:PRK14844   974 ndfekerdyiinvtseyfydelkkllinsgsQDREKFDSIEREQWWGIglknqsiseqVKSLKkdfdekvshaiaqfkrk 1053
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  341 ---LMEGED---GSKLS-KVSVRDERIPELGDKFASRHGQKGVVGHIAPQEDMPFTEQGVVPDLIINPHALPSRMTVGHV 413
Cdd:PRK14844  1054 vekLHEGYDlpqGVSMSvKVFIAVKHSLQPGDKMAGRHGNKGVISRVVPVEDMPYLEDGTPVDIILNPLGVPSRMNVGQI 1133
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  414 LEM--------IGGKVGA-------------------------------LEGRRVD------------GTPFTGEDEDEL 442
Cdd:PRK14844  1134 LEThvgwackkLGEKVGNildeinkiksafckgirslnddnftkfaaayLDNKKIEnidddeitasvlNTPNKNALNDEL 1213
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  443 -----------------------------------------------------RGGL-------------------EEQG 450
Cdd:PRK14844  1214 nelvenylnscksaysnlrnflievyscgsnvsicnnirdisdnnliefarklRDGIpvaapvfegpkdeqiaklfELAG 1293
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1561178664  451 FKSSGKEIMYSGVTGEKIEAEIFIGTIFYQKLYHMVSNKLHARSRGPVQVLTRQPTEGRAREGGLRVGEMERDVLIGHGA 530
Cdd:PRK14844  1294 LDNSGQAVLYDGCSGEKFDRKVTVGYMYMLKLHHLVDGKIHARSVGPYSLVTQQPLGGKSHFGGQRFGEMECWALQAYGA 1373
                          730
                   ....*....|...
gi 1561178664  531 ALTLKERLLDESD 543
Cdd:PRK14844  1374 AYTLQEMLTVKSD 1386
RNA_pol_Rpb2_4 pfam04566
RNA polymerase Rpb2, domain 4; RNA polymerases catalyze the DNA dependent polymerization of ...
9-70 3.50e-26

RNA polymerase Rpb2, domain 4; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 4, is also known as the external 2 domain.


Pssm-ID: 428012 [Multi-domain]  Cd Length: 62  Bit Score: 101.29  E-value: 3.50e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1561178664   9 VYVNGSLVGTHPDPEQLAEQVRHARRRGDVSEMVNVSVKERTREVIINADAGRARRPLLVVE 70
Cdd:pfam04566   1 VFLNGNLIGVHRDPEELVETLRKLRRSGKISEEVSIVRDIREKEVRINTDGGRVCRPLIIVE 62
RNA_pol_Rpb2_5 pfam04567
RNA polymerase Rpb2, domain 5; RNA polymerases catalyze the DNA dependent polymerization of ...
91-131 1.31e-10

RNA polymerase Rpb2, domain 5; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 5, is also known as the external 2 domain.


Pssm-ID: 428013 [Multi-domain]  Cd Length: 53  Bit Score: 56.78  E-value: 1.31e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1561178664  91 FDDLVERGKVEFIDAEEEEDIYVAVDEDDLSED------------HTHLEVDP 131
Cdd:pfam04567   1 WSDLLREGVIEYLDAEEEETSMIAMTPEDLEESsreeregpyahtYTHCEIHP 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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