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Conserved domains on  [gi|1565696187|ref|WP_129045680|]
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helix-turn-helix transcriptional regulator [Companilactobacillus metriopterae]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-92 2.42e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 87.64  E-value: 2.42e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565696187  1 MTIEQKDMKRSEIFKVLSDPNRIRMIRILYSngSEMTCGEVGDKLSISKSTVSYHFKILRSVGLTNTRRESRNKFLSLNL 80
Cdd:COG0640    1 MSETKELEELAELFKALADPTRLRILRLLAE--GELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLAD 78

                         90
                 ....*....|..
gi 1565696187 81 NTFDEYLPGFLD 92
Cdd:COG0640   79 EALAELLEWLLE 90
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-92 2.42e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 87.64  E-value: 2.42e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565696187  1 MTIEQKDMKRSEIFKVLSDPNRIRMIRILYSngSEMTCGEVGDKLSISKSTVSYHFKILRSVGLTNTRRESRNKFLSLNL 80
Cdd:COG0640    1 MSETKELEELAELFKALADPTRLRILRLLAE--GELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLAD 78

                         90
                 ....*....|..
gi 1565696187 81 NTFDEYLPGFLD 92
Cdd:COG0640   79 EALAELLEWLLE 90
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 11-79 2.34e-18

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 72.11  E-value: 2.34e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1565696187 11 SEIFKVLSDPNRIRMIRILYSNgsEMTCGEVGDKLSISKSTVSYHFKILRSVGLTNTRRESRNKFLSLN 79
Cdd:NF033788   2 AELFKALADPTRLRILELLAEG--ELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLA 68
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 13-92 2.48e-17

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 69.36  E-value: 2.48e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565696187 13 IFKVLSDPNRIRMIRILysNGSEMTCGEVGDKLSISKSTVSYHFKILRSVGLTNTRRESRNKFLSLNLNTFDEYLPGFLD 92
Cdd:NF033789   1 TFKALSDPTRREILELL--KEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTTVFEEVLGWLLD 78
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 12-72 5.65e-17

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 67.95  E-value: 5.65e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1565696187 12 EIFKVLSDPNRIRMIRILYSNGsEMTCGEVGDKLSISKSTVSYHFKILRSVGLTNTRRESR 72
Cdd:pfam12840  2 DVAEALADPTRLRILRALVGDE-PLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 14-79 8.01e-15

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 63.09  E-value: 8.01e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1565696187 14 FKVLSDPNRIRMIRILYSNgsEMTCGEVGDKLSISKSTVSYHFKILRSVGLTNTRRESRNKFLSLN 79
Cdd:cd00090    1 LKALSDPTRLRILRLLLEG--PLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLT 64
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
24-91 2.26e-12

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 56.45  E-value: 2.26e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1565696187  24 RMIRILYsnGSEMTCGEVGDKLSISKSTVSYHFKILRSVGLTNTRRESRNKFLSLNLNTFDEYLPGFL 91
Cdd:smart00418  1 KILKLLA--EGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 12-72 2.01e-04

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 37.10  E-value: 2.01e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1565696187  12 EIFKVLSDPNRIRMIRILYSNGsEMTCGEVGDKLSISKSTVSYHFKILRSVGLTNTRRESR 72
Cdd:PRK10141    8 QLFKILSDETRLGIVLLLRESG-ELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGK 67
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-92 2.42e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 87.64  E-value: 2.42e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565696187  1 MTIEQKDMKRSEIFKVLSDPNRIRMIRILYSngSEMTCGEVGDKLSISKSTVSYHFKILRSVGLTNTRRESRNKFLSLNL 80
Cdd:COG0640    1 MSETKELEELAELFKALADPTRLRILRLLAE--GELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLAD 78

                         90
                 ....*....|..
gi 1565696187 81 NTFDEYLPGFLD 92
Cdd:COG0640   79 EALAELLEWLLE 90
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 11-79 2.34e-18

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 72.11  E-value: 2.34e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1565696187 11 SEIFKVLSDPNRIRMIRILYSNgsEMTCGEVGDKLSISKSTVSYHFKILRSVGLTNTRRESRNKFLSLN 79
Cdd:NF033788   2 AELFKALADPTRLRILELLAEG--ELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLA 68
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 13-92 2.48e-17

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 69.36  E-value: 2.48e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565696187 13 IFKVLSDPNRIRMIRILysNGSEMTCGEVGDKLSISKSTVSYHFKILRSVGLTNTRRESRNKFLSLNLNTFDEYLPGFLD 92
Cdd:NF033789   1 TFKALSDPTRREILELL--KEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTTVFEEVLGWLLD 78
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 12-72 5.65e-17

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 67.95  E-value: 5.65e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1565696187 12 EIFKVLSDPNRIRMIRILYSNGsEMTCGEVGDKLSISKSTVSYHFKILRSVGLTNTRRESR 72
Cdd:pfam12840  2 DVAEALADPTRLRILRALVGDE-PLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 14-79 8.01e-15

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 63.09  E-value: 8.01e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1565696187 14 FKVLSDPNRIRMIRILYSNgsEMTCGEVGDKLSISKSTVSYHFKILRSVGLTNTRRESRNKFLSLN 79
Cdd:cd00090    1 LKALSDPTRLRILRLLLEG--PLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLT 64
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
12-74 1.09e-13

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 60.74  E-value: 1.09e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1565696187 12 EIFKVLSDPNRIRMIRILYSNgsEMTCGEVGDKLSISKSTVSYHFKILRSVGLTNTRRESRNK 74
Cdd:COG4189   11 EVLKALASETRLRILRLLAEE--PLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYKPGKR 71
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
24-91 2.26e-12

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 56.45  E-value: 2.26e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1565696187  24 RMIRILYsnGSEMTCGEVGDKLSISKSTVSYHFKILRSVGLTNTRRESRNKFLSLNLNTFDEYLPGFL 91
Cdd:smart00418  1 KILKLLA--EGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 19-64 7.14e-08

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 44.36  E-value: 7.14e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 1565696187 19 DPNRIRMIRILysNGSEMTCGEVGDKLSISKSTVSYHFKILRSVGL 64
Cdd:pfam01022  1 DPTRLKILKLL--AEGELCVCELAEELGLSQSTVSHHLKKLREAGL 44
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
13-79 1.63e-07

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 46.02  E-value: 1.63e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1565696187  13 IFKVLSDPNRIRMIRILYSNGSeMTCGEVGDKLSISKSTVSYHFKILRSVGLTNTRRESRNKFLSLN 79
Cdd:COG3398    90 ILAYLRRETPRRILLYLLENPG-ATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLN 155
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 12-72 2.01e-04

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 37.10  E-value: 2.01e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1565696187  12 EIFKVLSDPNRIRMIRILYSNGsEMTCGEVGDKLSISKSTVSYHFKILRSVGLTNTRRESR 72
Cdd:PRK10141    8 QLFKILSDETRLGIVLLLRESG-ELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGK 67
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 19-78 1.39e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 34.50  E-value: 1.39e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565696187 19 DPNRIRMIRILYSNGSEMTCGEVGDKLSISKSTVSYHFKILRSVGLTNTRRESRNKFLSL 78
Cdd:COG2512   14 LEDERRVLELLRENGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKERVGRENVVEL 73
GbsR COG1510
DNA-binding transcriptional regulator GbsR, MarR family [Transcription];
21-64 2.25e-03

DNA-binding transcriptional regulator GbsR, MarR family [Transcription];


Pssm-ID: 441119  Cd Length: 164  Bit Score: 34.91  E-value: 2.25e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1565696187  21 NRI--RMIRILYSNGSEMTCGEVGDKLSISKSTVSYHFKILRSVGL 64
Cdd:COG1510    26 PRSagRIYALLYLSDEPLTADELAEELGVSKSSVSTALRELEDWGL 71
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
15-85 3.91e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 34.08  E-value: 3.91e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1565696187  15 KVLSDPNRIRMIRILYSN-GSEMTcgEVGDKLSISKSTVSYHFKILRSVGLTNTRRESRNKFLSLNLNTFDE 85
Cdd:COG3398    16 NVLDNDTRRRIYEYIRENpGIHFR--EIVRDLGLNRGTLRYHLRRLEREGKITSEKDGGRTRYFPNSGTYSE 85
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 24-64 4.80e-03

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 32.40  E-value: 4.80e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 1565696187 24 RMIRILYSNGSEMTCGEVGDKLSISKSTVSYHFKILRSVGL 64
Cdd:pfam08279  2 QILQLLLEARGPISGQELAEKLGVSRRTIRRDIKILEELGV 42
DmsR COG3413
Predicted transcriptional regulator, contains HTH domain [General function prediction only];
35-60 9.11e-03

Predicted transcriptional regulator, contains HTH domain [General function prediction only];


Pssm-ID: 442639 [Multi-domain]  Cd Length: 143  Bit Score: 32.99  E-value: 9.11e-03
                          10        20
                  ....*....|....*....|....*.
gi 1565696187  35 EMTCGEVGDKLSISKSTVSYHfkiLR 60
Cdd:COG3413   108 EATLEELAEELGISKSTLSEH---LR 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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