NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1590405811|ref|WP_131691612|]
View 

efflux RND transporter permease subunit [Pseudoalteromonas sp. DL-6]

Protein Classification

efflux RND transporter permease subunit( domain architecture ID 11467043)

efflux RND transporter permease subunit is an efflux membrane protein similar to Cupriavidus metallidurans ZneA, a proton driven, heavy metal efflux pump specific for Zn(II)

Gene Ontology:  GO:0016020|GO:0055085|GO:0022857
PubMed:  29577985
TCDB:  2.A.6

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
CusA COG3696
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
1-1021 0e+00

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];


:

Pssm-ID: 442911 [Multi-domain]  Cd Length: 1031  Bit Score: 1482.20  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811    1 MINWIVSFAVKRRMMVLALTFLFAGFGVYNIQNLAVDAVPDITNVQVQINSKAPGFTPLEVEQRITYLVETAMAGIPKLD 80
Cdd:COG3696      1 MLNRIIRFSLRNRLLVLLLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   81 YTRSLSRYGLSQVTIIFDEGTDIYWARQQIGERIQSIRADLPNNVEPNLGPIASGLGEIFTYsvhakpdALKSDGMPYSA 160
Cdd:COG3696     81 EVRSISRFGLSVVTVIFEDGTDIYWARQLVLERLQQVREQLPAGVTPELGPISTGLGEIYQY-------TLESDPGKYSL 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  161 EDLRTLQDWVIRPQLLKVKGVTEINSQGGFERQYQVAPIPEKLIAYKLTIKDVITALELNNSNRGAGYIERFDGQYLVRS 240
Cdd:COG3696    154 MELRTLQDWVIRPQLRSVPGVAEVNSFGGFVKQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERGGQEYLVRG 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  241 PGQLKTLADIANTVIAKRDDAPVRIKDVANVYLGKELRTGAATYNGE-ETVLGTAMMLIGENSRVVAKAMADKLIQVQKS 319
Cdd:COG3696    234 IGLIRSLEDIENIVVKTRNGTPVLLRDVAEVRIGPAPRRGAATLNGEgEVVGGIVLMLKGENALEVIEAVKAKLAELKPS 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  320 LPAGVIVEPVYDRTNLVDKTIATVQKNLFEGAVLVIVILLLLLGNITGALITAMVIPLSMLFAITGMVGNRVSGNLMSLG 399
Cdd:COG3696    314 LPEGVKIVPFYDRSDLIDRAIHTVTKNLLEGALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLG 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  400 --AIDFGLIVDGAVIVVENCLRQLGMAQHKHGRLltlsERLEVVTSATKEVFSPAVFGILIIMLVYLPLFALSGVEGKMF 477
Cdd:COG3696    394 glAIDFGIIVDGAVVMVENILRRLEENRAAGTPR----ERLEVVLEAAREVRRPIFFATLIIILVFLPIFTLEGVEGKLF 469
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  478 QPMAFTVVAALIGALIFAVTFVPAAIAVFVRGKVDESENAVMRGVKKIYKPLLNLSLKLPWLMISIATVLVLVLGFKVKN 557
Cdd:COG3696    470 RPMALTVIFALLGALLLSLTLVPVLASLLLRGKVPEKENPLVRWLKRLYRPLLRWALRHPKLVLAVALVLLVLALALFPR 549
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  558 MGAEFLPQLDEGDIAMHALRITGTGIEQSVQMQKQLEQALLAQPEIANVFSKIGTADVASDPMPPNVADTFLMLKPRAQW 637
Cdd:COG3696    550 LGSEFLPELDEGDLLVMATLPPGISLEESVELGQQVERILKSFPEVESVVSRTGRAEDATDPMGVNMSETFVILKPRSEW 629
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  638 PDPsLSKDALVQRIRHRVNEVPGNNYEFTQPIEMRFNELIAGVRADVALRIYGDDLAILKQFGEKATSLMRNITGATDVR 717
Cdd:COG3696    630 RSG-RTKEELIAEMREALEQIPGVNFNFSQPIQMRVDELLSGVRADVAVKIFGDDLDVLRRLAEQIEAVLKTVPGAADVQ 708
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  718 LEQMEGLPTLSVTPMRDHMALLGLTVNDIQQTLAAAVGGVQTGLIYEGDKRFSLLVRLDKRWSEDVSALARLPIALPQSs 797
Cdd:COG3696    709 VERVTGLPQLDIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQVYEGERRFDIVVRLPEELRDDPEAIRNLPIPTPSG- 787
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  798 npelAFVPLGEVATISIEKGPNQINRESGKRNVVVTANVAGRDLASFVRDAQATMNAQLNLPSGYWLEYGGTFEQLQSAS 877
Cdd:COG3696    788 ----AQVPLSQVADIEVVEGPNQISRENGRRRIVVQANVRGRDLGSFVAEAQAKVAEQVKLPPGYYIEWGGQFENLQRAT 863
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  878 KRLSLVVPVTLLLIFGLLYSAFGSLRDSLIIFSGVPLALTGGVLALLLRDMPLSISAGVGFIALSGVAVLNGVVMLSFIK 957
Cdd:COG3696    864 ARLAIVVPLALLLIFLLLYLAFGSVRDALLILLNVPFALIGGVLALWLRGMPLSVSAGVGFIALFGVAVLNGVVLVSYIN 943
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1590405811  958 QLRNEGLSLYYAIHSGALQRLRPVLMTALVASLGFIPMALNTGTGAEIQRPLATVVVGGIMSST 1021
Cdd:COG3696    944 QLRAEGLDLREAIIEGALERLRPVLMTALVAALGLLPMALSTGPGSEVQRPLATVVIGGLITST 1007
 
Name Accession Description Interval E-value
CusA COG3696
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
1-1021 0e+00

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];


Pssm-ID: 442911 [Multi-domain]  Cd Length: 1031  Bit Score: 1482.20  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811    1 MINWIVSFAVKRRMMVLALTFLFAGFGVYNIQNLAVDAVPDITNVQVQINSKAPGFTPLEVEQRITYLVETAMAGIPKLD 80
Cdd:COG3696      1 MLNRIIRFSLRNRLLVLLLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   81 YTRSLSRYGLSQVTIIFDEGTDIYWARQQIGERIQSIRADLPNNVEPNLGPIASGLGEIFTYsvhakpdALKSDGMPYSA 160
Cdd:COG3696     81 EVRSISRFGLSVVTVIFEDGTDIYWARQLVLERLQQVREQLPAGVTPELGPISTGLGEIYQY-------TLESDPGKYSL 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  161 EDLRTLQDWVIRPQLLKVKGVTEINSQGGFERQYQVAPIPEKLIAYKLTIKDVITALELNNSNRGAGYIERFDGQYLVRS 240
Cdd:COG3696    154 MELRTLQDWVIRPQLRSVPGVAEVNSFGGFVKQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERGGQEYLVRG 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  241 PGQLKTLADIANTVIAKRDDAPVRIKDVANVYLGKELRTGAATYNGE-ETVLGTAMMLIGENSRVVAKAMADKLIQVQKS 319
Cdd:COG3696    234 IGLIRSLEDIENIVVKTRNGTPVLLRDVAEVRIGPAPRRGAATLNGEgEVVGGIVLMLKGENALEVIEAVKAKLAELKPS 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  320 LPAGVIVEPVYDRTNLVDKTIATVQKNLFEGAVLVIVILLLLLGNITGALITAMVIPLSMLFAITGMVGNRVSGNLMSLG 399
Cdd:COG3696    314 LPEGVKIVPFYDRSDLIDRAIHTVTKNLLEGALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLG 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  400 --AIDFGLIVDGAVIVVENCLRQLGMAQHKHGRLltlsERLEVVTSATKEVFSPAVFGILIIMLVYLPLFALSGVEGKMF 477
Cdd:COG3696    394 glAIDFGIIVDGAVVMVENILRRLEENRAAGTPR----ERLEVVLEAAREVRRPIFFATLIIILVFLPIFTLEGVEGKLF 469
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  478 QPMAFTVVAALIGALIFAVTFVPAAIAVFVRGKVDESENAVMRGVKKIYKPLLNLSLKLPWLMISIATVLVLVLGFKVKN 557
Cdd:COG3696    470 RPMALTVIFALLGALLLSLTLVPVLASLLLRGKVPEKENPLVRWLKRLYRPLLRWALRHPKLVLAVALVLLVLALALFPR 549
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  558 MGAEFLPQLDEGDIAMHALRITGTGIEQSVQMQKQLEQALLAQPEIANVFSKIGTADVASDPMPPNVADTFLMLKPRAQW 637
Cdd:COG3696    550 LGSEFLPELDEGDLLVMATLPPGISLEESVELGQQVERILKSFPEVESVVSRTGRAEDATDPMGVNMSETFVILKPRSEW 629
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  638 PDPsLSKDALVQRIRHRVNEVPGNNYEFTQPIEMRFNELIAGVRADVALRIYGDDLAILKQFGEKATSLMRNITGATDVR 717
Cdd:COG3696    630 RSG-RTKEELIAEMREALEQIPGVNFNFSQPIQMRVDELLSGVRADVAVKIFGDDLDVLRRLAEQIEAVLKTVPGAADVQ 708
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  718 LEQMEGLPTLSVTPMRDHMALLGLTVNDIQQTLAAAVGGVQTGLIYEGDKRFSLLVRLDKRWSEDVSALARLPIALPQSs 797
Cdd:COG3696    709 VERVTGLPQLDIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQVYEGERRFDIVVRLPEELRDDPEAIRNLPIPTPSG- 787
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  798 npelAFVPLGEVATISIEKGPNQINRESGKRNVVVTANVAGRDLASFVRDAQATMNAQLNLPSGYWLEYGGTFEQLQSAS 877
Cdd:COG3696    788 ----AQVPLSQVADIEVVEGPNQISRENGRRRIVVQANVRGRDLGSFVAEAQAKVAEQVKLPPGYYIEWGGQFENLQRAT 863
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  878 KRLSLVVPVTLLLIFGLLYSAFGSLRDSLIIFSGVPLALTGGVLALLLRDMPLSISAGVGFIALSGVAVLNGVVMLSFIK 957
Cdd:COG3696    864 ARLAIVVPLALLLIFLLLYLAFGSVRDALLILLNVPFALIGGVLALWLRGMPLSVSAGVGFIALFGVAVLNGVVLVSYIN 943
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1590405811  958 QLRNEGLSLYYAIHSGALQRLRPVLMTALVASLGFIPMALNTGTGAEIQRPLATVVVGGIMSST 1021
Cdd:COG3696    944 QLRAEGLDLREAIIEGALERLRPVLMTALVAALGLLPMALSTGPGSEVQRPLATVVIGGLITST 1007
2A0601 TIGR00914
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ...
1-1043 0e+00

heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129992 [Multi-domain]  Cd Length: 1051  Bit Score: 1335.94  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811    1 MINWIVSFAVKRRMMVLALTFLFAGFGVYNIQNLAVDAVPDITNVQVQINSKAPGFTPLEVEQRITYLVETAMAGIPKLD 80
Cdd:TIGR00914    1 MIERIISFSVAQRWLVLLATLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   81 YTRSLSRYGLSQVTIIFDEGTDIYWARQQIGERIQSIRADLPNNVEPNLGPIASGLGEIFTYSVHAKPDALKSDGMPYSA 160
Cdd:TIGR00914   81 TTRSLSRYGLSQVTVIFKDGTDLYFARQLVNERLQQARDNLPEGVSPEMGPISTGLGEIFLYTVEAEEGARKKDGGAYTL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  161 EDLRTLQDWVIRPQLLKVKGVTEINSQGGFERQYQVAPIPEKLIAYKLTIKDVITALELNNSNRGAGYIERFDGQYLVRS 240
Cdd:TIGR00914  161 TDLRTIQDWIIRPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRA 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  241 PGQLKTLADIANTVIAKRDDAPVRIKDVANVYLGKELRTGAATYNGEETVLGTAMMLIGENSRVVAKAMADKLIQVQKSL 320
Cdd:TIGR00914  241 PGQVQSMDDIRNIVIATGEGVPIRIRDVARVQIGKELRTGAATENGKEVVLGTVFMLIGENSRTVAQAVGDKLETINKTL 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  321 PAGVIVEPVYDRTNLVDKTIATVQKNLFEGAVLVIVILLLLLGNITGALITAMVIPLSMLFAITGMVGNRVSGNLMSLGA 400
Cdd:TIGR00914  321 PEGVEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSLGA 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  401 IDFGLIVDGAVIVVENCLRQLGMAQHKHGRLLTLSERLEVVTSATKEVFSPAVFGILIIMLVYLPLFALSGVEGKMFQPM 480
Cdd:TIGR00914  401 LDFGLIVDGAVVIVENAHRRLAEAQHHHGRQLTLKERLHEVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGKMFHPM 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  481 AFTVVAALIGALIFAVTFVPAAIAVFVRGKVDESENAVMRGVKKIYKPLLNLSLKLPWLMISIATVLVLVLGFKVKNMGA 560
Cdd:TIGR00914  481 AFTVVLALAGAMILSLTFVPAAVALFIRGKVAEKENRLMRVLKRRYEPLLERVLAWPAVVLGAAAVSIVLVVWIASRVGG 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  561 EFLPQLDEGDIAMHALRITGTGIEQSVQMQKQLEQALLAQPEIANVFSKIGTADVASDPMPPNVADTFLMLKPRAQWPDP 640
Cdd:TIGR00914  561 EFIPSLNEGDLAYQALRIPGTSLAQSVAMQQTLEKLIKSFPEVARVFAKTGTAEIATDPMPPNASDTYIILKPESQWPEG 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  641 SLSKDALVQRIRHRVNEVPGNNYEFTQPIEMRFNELIAGVRADVALRIYGDDLAILKQFGEKATSLMRNITGATDVRLEQ 720
Cdd:TIGR00914  641 KKTKEDLIEEIQEATVRIPGNNYEFTQPIQMRFNELISGVRSDVAVKVFGDDLDDLDATAEKISAVLKGVPGAADVKVEQ 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  721 MEGLPTLSVTPMRDHMALLGLTVNDIQQTLAAAVGGVQTGLIYEGDKRFSLLVRLDKRWSEDVSALARLPIALPQSSNPE 800
Cdd:TIGR00914  721 TTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRFDIVIRLPESLRESPQALRQLPIPLPLSEDAR 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  801 LAFVPLGEVATISIEKGPNQINRESGKRNVVVTANVAGRDLASFVRDAQATMNAQLNLPSGYWLEYGGTFEQLQSASKRL 880
Cdd:TIGR00914  801 KQFIPLSDVADLRVSPGPNQISRENGKRRVVVSANVRGRDLGSFVDDAKKAIAEQVKLPPGYWITWGGQFEQLQSATKRL 880
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  881 SLVVPVTLLLIFGLLYSAFGSLRDSLIIFSGVPLALTGGVLALLLRDMPLSISAGVGFIALSGVAVLNGVVMLSFIKQLR 960
Cdd:TIGR00914  881 QIVVPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMISFIRKLL 960
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  961 NEGLSLYYAIHSGALQRLRPVLMTALVASLGFIPMALNTGTGAEIQRPLATVVVGGIMSSTLLTLLILPALYKLVHGKFK 1040
Cdd:TIGR00914  961 EEGPSLDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQRPLATVVIGGIITATLLTLFVLPALYRLVHRRRH 1040

                   ...
gi 1590405811 1041 KQQ 1043
Cdd:TIGR00914 1041 KGR 1043
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
5-1036 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 950.58  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811    5 IVSFAVKRRMMVLALTFLFAGFGVYNIQNLAVDAVPDITNVQVQINSKAPGFTPLEVEQRITYLVETAMAGIPKLDYTRS 84
Cdd:pfam00873    1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   85 LSRYGLSQVTIIFDEGTDIYWARQQIGERIQSIRADLPNNV-EPNLGPIASGLGEIFTYsvhakpdALKSDGMPYSAEDL 163
Cdd:pfam00873   81 QSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGVqRPGISVIKTSLGPIMVL-------AVTSPDGSYTQTDL 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  164 RTLQDWVIRPQLLKVKGVTEINSQGGFERQYQVAPIPEKLIAYKLTIKDVITALELNNSNRGAGYIERFDGQYLVRSPGQ 243
Cdd:pfam00873  154 RDYADTNIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQ 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  244 LKTLADIANTVIAKRDDAPVRIKDVANVYLGKELRTGAATYNGEETVLGTAMMLIGENSRVVAKAMADKLIQVQKSLPAG 323
Cdd:pfam00873  234 LQSAEDFEKIIVKNQDGSPVRLRDVATVELGSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQG 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  324 VIVEPVYDRTNLVDKTIATVQKNLFEGAVLVIVILLLLLGNITGALITAMVIPLSMLFAITGMVGNRVSGNLMSLGAIDF 403
Cdd:pfam00873  314 VEIVVVYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVL 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  404 --GLIVDGAVIVVENCLRQLGMAQHKHgrlltlserLEVVTSATKEVFSPAVFGILIIMLVYLPLFALSGVEGKMFQPMA 481
Cdd:pfam00873  394 aiGLVVDDAIVVVENIERVLEENGLKP---------LEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFA 464
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  482 FTVVAALIGALIFAVTFVPAAIAVFVRGKVDESE-------NAVMRGVKKIYKPLLNLSLKLPWLMISIATVLVLVLGFK 554
Cdd:pfam00873  465 ITIVLAILLSVLVALTLTPALCATLLKPRREPKHggffrwfNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWL 544
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  555 VKNMGAEFLPQLDEGDIAMHALRITGTGIEQSVQMQKQLEQALLAQPEIANVFSKIGTADvASDPMPPNVADTFLMLKPR 634
Cdd:pfam00873  545 FVRIPTEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFAF-SGDNNGPNSGDAFISLKPW 623
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  635 AQWPDPSLSKDALVQRIRHRVNEVPGNNYEFTQPIEMRFNELIAGVRADVALRIYGDDLAILKQFGEKATSLMRNITGAT 714
Cdd:pfam00873  624 KERPGPEKSVQALIERLRKALKQIPGANVFLFQPIQLRGLGTISGFRSDLQVKIFGDDLDALDEARNQILAALAQLPGLS 703
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  715 DVRLEQMEGLPTLSVTPMRDHMALLGLTVNDIQQTLAAAVGGVQTGLIYEGDKRFSLLVRLDKRWSEDVSALARLPIalp 794
Cdd:pfam00873  704 DVRSDGQEDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYV--- 780
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  795 qsSNPELAFVPLGEVATISIEKGPNQINRESGKRNVVVTANVAGRDLASFVRDAQATMNAQLNLPSGYWLEYGGTFEQLQ 874
Cdd:pfam00873  781 --RNPYGKMIPLSAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVKLPPGYGYTWTGQFEQEQ 858
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  875 SASKRLSLVVPVTLLLIFGLLYSAFGSLRDSLIIFSGVPLALTGGVLALLLRDMPLSISAGVGFIALSGVAVLNGVVMLS 954
Cdd:pfam00873  859 LAGNSLPILIALALLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVE 938
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  955 FIKQLR-NEGLSLYYAIHSGALQRLRPVLMTALVASLGFIPMALNTGTGAEIQRPLATVVVGGIMSSTLLTLLILPALYK 1033
Cdd:pfam00873  939 FANELReQEGKSLEEAILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPVFYV 1018

                   ...
gi 1590405811 1034 LVH 1036
Cdd:pfam00873 1019 LFH 1021
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
10-1021 1.85e-123

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 402.09  E-value: 1.85e-123
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   10 VKRRMMVLALTFLFAGFGVYNIQNLAVDAVPDITNVQVQINSKAPGFTPLEVEQRITYLVETAMAGIPKLDYTRSLSRYG 89
Cdd:NF033617     5 IKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQSSLG 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   90 LSQVTIIFDEGTDIYWARQQIGERIQSIRADLPNN-----VEPNLGPIASGLGEIftysvhakpdALKSDGMPYSAedLR 164
Cdd:NF033617    85 YSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEapdppVYRKANSADTPIMYI----------GLTSEEMPRGQ--LT 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  165 TLQDWVIRPQLLKVKGVTEINSQGGFERQYQVAPIPEKLIAYKLTIKDVITALELNNSNRGAGYIERFDGQYLVRSPGQL 244
Cdd:NF033617   153 DYAERVLAPKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQL 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  245 KTLADIANTVIAKRDD-APVRIKDVANVYLGKELRTGAATYNGEETVLGTAMMLIGENSRVVAKAMADKLIQVQKSLPAG 323
Cdd:NF033617   233 KTAEDYEDLVIKYADNgAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLPKN 312
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  324 VIVEPVYDRTNLVDKTIATVQKNLFEGAVLVIVILLLLLGNITGALITAMVIPLSMLFAITGMVGNRVSGNLMSLGA--I 401
Cdd:NF033617   313 IKVNVLYDRTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMAlvL 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  402 DFGLIVDGAVIVVENCLRQL--GMAQhkhgrlltlserLEVVTSATKEVFSPAVFGILIIMLVYLPLFALSGVEGKMFQP 479
Cdd:NF033617   393 AIGLVVDDAIVVVENIHRHIeeGESP------------LEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFRE 460
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  480 MAFTVVAALIGALIFAVTFVPAAIAVFVRGKVDESENA-----VMRGVKKIYKPLLNLSLKLPWLMISIA--TVLVLVLG 552
Cdd:NF033617   461 FAVTLAGAVIISGIVALTLTPMMCSRLLKANEKPGRFAravdrFFDGLTARYGRGLKWVLKHRPLTLVVAlaTLALLPLL 540
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  553 FKVknMGAEFLPQLDEGDIAMHALRITGTGIEQSVQMQKQLEQALLAQPEIANVFSKIGTADVASDpmppNVADTFLMLK 632
Cdd:NF033617   541 YVF--IPKELAPSEDRGVIFGMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTSFNGVGGNPGD----NTGFGIINLK 614
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  633 PraqWPDPSLSKDALVQRIRHRVNEVPGnnyefTQPIEMRFNELIAGVRADVALRIY---GDDLAILKQFGEKATSLMRN 709
Cdd:NF033617   615 P---WDERDVSAQEIIDRLRPKLAKVPG-----MDLFLFPLQDLPGGAGSSLPQYQVtltPSDYDSLFTWAEKLKEKLRK 686
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  710 ITGATDVRLEQMEGLPTLSVTPMRDHMALLGLTVNDIQQTLAAAVGGVQTGLIYEGDKRFSLLVRLDKRWSEDVSALARL 789
Cdd:NF033617   687 SPQFADVDSDLQDKGPELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQI 766
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  790 PIalpQSSNPELafVPLGEVATISIEKGPNQINRESGKRNVVVTANVA-GRDLASFVrdaQATMN-AQLNLPSGYWLEYG 867
Cdd:NF033617   767 YV---RSNDGKL--VPLSTLAKIEERAAPLSLNHFNQFNSATLSFNLApGVSLGEAI---EALDQaAKELLPSGISGSFQ 838
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  868 GTFEQLQSASKRLSLVVPVTLLLIFGLLYSAFGSLRDSLIIFSGVPLALTGGVLALLLRDMPLSISAGVGFIALSGVAVL 947
Cdd:NF033617   839 GAARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKK 918
                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1590405811  948 NGVVMLSFIKQL-RNEGLSLYYAIHSGALQRLRPVLMTALVASLGFIPMALNTGTGAEIQRPLATVVVGGIMSST 1021
Cdd:NF033617   919 NGILMVEFANELqRHQGLSRREAIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGT 993
PRK09577 PRK09577
multidrug efflux RND transporter permease subunit;
16-1021 2.20e-64

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169981 [Multi-domain]  Cd Length: 1032  Bit Score: 236.67  E-value: 2.20e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   16 VLALTFLFAGfgVYNIQNLAVDAVPDITNVQVQINSKAPGFTPLEVEQRITYLVETAMAGIPKLDYTRSLSRYGLSQVTI 95
Cdd:PRK09577    14 VISLFIMLGG--IFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSATSSAGQASLSL 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   96 IFDEGTDIYWARQQIGERIQSIRADLPNNVEPNlGPIASGLGEIFTYSVhakpdALKSDGMPYSAEDLRTLQDWVIRPQL 175
Cdd:PRK09577    92 TFKQGVNADLAAVEVQNRLKTVEARLPEPVRRD-GIQVEKAADNIQLIV-----SLTSDDGRLTGVELGEYASANVLQAL 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  176 LKVKGVTEINSQGGfERQYQVAPIPEKLIAYKLTIKDVITALELNNSNRGAGYIERF---DGQYL---VRSPGQLKTLAD 249
Cdd:PRK09577   166 RRVEGVGKVQFWGA-EYAMRIWPDPVKLAALGLTASDIASAVRAHNARVTIGDIGRSavpDSAPIaatVFADAPLKTPED 244
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  250 IANTVI-AKRDDAPVRIKDVANVYLGKELRTGAATYNGEETVLGTAMMLIGENSRVVAKAMADKLIQVQKSLPAGVIVEP 328
Cdd:PRK09577   245 FGAIALrARADGSALYLRDVARIEFGGNDYNYPSYVNGKTATGMGIKLAPGSNAVATEKRVRATMDELSRYFPPGVKYQI 324
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  329 VYDRTNLVDKTIATVQKNLFEGAVLVIVILLLLLGNITGALITAMVIPLSMLFAITGMVGNRVSGNLMSL--GAIDFGLI 406
Cdd:PRK09577   325 PYETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGFSINVLTMfgMVLAIGIL 404
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  407 VDGAVIVVENCLRqlgmaqhkhgrlLTLSERL---EVVTSATKEVfSPAVFGILIIML-VYLPLFALSGVEGKMFQPMAF 482
Cdd:PRK09577   405 VDDAIVVVENVER------------LMVEEGLspyDATVKAMKQI-SGAIVGITVVLTsVFVPMAFFGGAVGNIYRQFAL 471
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  483 TVVAALIGALIFAVTFVPAAIAVFVRGKVDESEN----------AVMRGVKKiYKPLLNLSLKLP--WLMISIATVLVLV 550
Cdd:PRK09577   472 SLAVSIGFSAFLALSLTPALCATLLKPVDGDHHEkrgffgwfnrFVARSTQR-YATRVGAILKRPlrWLVVYGALTAAAA 550
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  551 LGFkvKNMGAEFLPQLDEGDIAMHALRITGTGIEQSVQMQKQLEQALLAQPEIANVFSkIGTADVASDpmPPNVADTFLM 630
Cdd:PRK09577   551 LLF--TRLPTAFLPDEDQGNFMVMVIRPQGTPLAETMQSVREVESYLRRHEPVAYTFA-LGGFNLYGE--GPNGGMIFVT 625
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  631 LKPRAQWPDPSLSKDALVQRIRHRVNEVPGNN-YEFTQPiemRFNELIAGVRADVALRIYGD-DLAILKQFGEKATSLMR 708
Cdd:PRK09577   626 LKDWKERKAARDHVQAIVARINERFAGTPNTTvFAMNSP---ALPDLGSTSGFDFRLQDRGGlGYAAFVAAREQLLAEGA 702
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  709 NITGATDVRLEQMEGLPTLSVTPMRDHMALLGLTVNDIQQTLAAAVGGVQTGLIYEGDKRFSLLVRLDKRWSEDVSALAR 788
Cdd:PRK09577   703 KDPALTDLMFAGTQDAPQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGDFMHGSQVRRVIVQADGRHRLDPDDVKK 782
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  789 LPIalpQSSNPELafVPLGEVATISIEKGPNQINRESGKRNVVVTANVA-----GRDLASFVRDAQatmnaqlNLPSGYW 863
Cdd:PRK09577   783 LRV---RNAQGEM--VPLAAFATLHWTLGPPQLTRYNGYPSFTINGSAApghssGEAMAAIERIAA-------TLPAGIG 850
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  864 LEYGGtfeqlQSASKRLS-----LVVPVTLLLIFGLLYSAFGSLRDSLIIFSGVPLALTGGVLALLLRDMPLSISAGVGF 938
Cdd:PRK09577   851 YAWSG-----QSFEERLSgaqapMLFALSVLVVFLALAALYESWSIPFAVMLVVPLGVIGAVLGVTLRGMPNDIYFKVGL 925
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  939 IALSGVAVLNGVVMLSFIKQLRNEGLSLYYAIHSGALQRLRPVLMTALVASLGFIPMALNTGTGAEIQRPLATVVVGGIM 1018
Cdd:PRK09577   926 IATIGLSAKNAILIVEVAKDLVAQRMSLADAALEAARLRLRPIVMTSLAFGVGVLPLAFASGAASGAQIAIGTGVLGGVI 1005

                   ...
gi 1590405811 1019 SST 1021
Cdd:PRK09577  1006 TAT 1008
 
Name Accession Description Interval E-value
CusA COG3696
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
1-1021 0e+00

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];


Pssm-ID: 442911 [Multi-domain]  Cd Length: 1031  Bit Score: 1482.20  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811    1 MINWIVSFAVKRRMMVLALTFLFAGFGVYNIQNLAVDAVPDITNVQVQINSKAPGFTPLEVEQRITYLVETAMAGIPKLD 80
Cdd:COG3696      1 MLNRIIRFSLRNRLLVLLLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   81 YTRSLSRYGLSQVTIIFDEGTDIYWARQQIGERIQSIRADLPNNVEPNLGPIASGLGEIFTYsvhakpdALKSDGMPYSA 160
Cdd:COG3696     81 EVRSISRFGLSVVTVIFEDGTDIYWARQLVLERLQQVREQLPAGVTPELGPISTGLGEIYQY-------TLESDPGKYSL 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  161 EDLRTLQDWVIRPQLLKVKGVTEINSQGGFERQYQVAPIPEKLIAYKLTIKDVITALELNNSNRGAGYIERFDGQYLVRS 240
Cdd:COG3696    154 MELRTLQDWVIRPQLRSVPGVAEVNSFGGFVKQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERGGQEYLVRG 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  241 PGQLKTLADIANTVIAKRDDAPVRIKDVANVYLGKELRTGAATYNGE-ETVLGTAMMLIGENSRVVAKAMADKLIQVQKS 319
Cdd:COG3696    234 IGLIRSLEDIENIVVKTRNGTPVLLRDVAEVRIGPAPRRGAATLNGEgEVVGGIVLMLKGENALEVIEAVKAKLAELKPS 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  320 LPAGVIVEPVYDRTNLVDKTIATVQKNLFEGAVLVIVILLLLLGNITGALITAMVIPLSMLFAITGMVGNRVSGNLMSLG 399
Cdd:COG3696    314 LPEGVKIVPFYDRSDLIDRAIHTVTKNLLEGALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLG 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  400 --AIDFGLIVDGAVIVVENCLRQLGMAQHKHGRLltlsERLEVVTSATKEVFSPAVFGILIIMLVYLPLFALSGVEGKMF 477
Cdd:COG3696    394 glAIDFGIIVDGAVVMVENILRRLEENRAAGTPR----ERLEVVLEAAREVRRPIFFATLIIILVFLPIFTLEGVEGKLF 469
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  478 QPMAFTVVAALIGALIFAVTFVPAAIAVFVRGKVDESENAVMRGVKKIYKPLLNLSLKLPWLMISIATVLVLVLGFKVKN 557
Cdd:COG3696    470 RPMALTVIFALLGALLLSLTLVPVLASLLLRGKVPEKENPLVRWLKRLYRPLLRWALRHPKLVLAVALVLLVLALALFPR 549
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  558 MGAEFLPQLDEGDIAMHALRITGTGIEQSVQMQKQLEQALLAQPEIANVFSKIGTADVASDPMPPNVADTFLMLKPRAQW 637
Cdd:COG3696    550 LGSEFLPELDEGDLLVMATLPPGISLEESVELGQQVERILKSFPEVESVVSRTGRAEDATDPMGVNMSETFVILKPRSEW 629
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  638 PDPsLSKDALVQRIRHRVNEVPGNNYEFTQPIEMRFNELIAGVRADVALRIYGDDLAILKQFGEKATSLMRNITGATDVR 717
Cdd:COG3696    630 RSG-RTKEELIAEMREALEQIPGVNFNFSQPIQMRVDELLSGVRADVAVKIFGDDLDVLRRLAEQIEAVLKTVPGAADVQ 708
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  718 LEQMEGLPTLSVTPMRDHMALLGLTVNDIQQTLAAAVGGVQTGLIYEGDKRFSLLVRLDKRWSEDVSALARLPIALPQSs 797
Cdd:COG3696    709 VERVTGLPQLDIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQVYEGERRFDIVVRLPEELRDDPEAIRNLPIPTPSG- 787
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  798 npelAFVPLGEVATISIEKGPNQINRESGKRNVVVTANVAGRDLASFVRDAQATMNAQLNLPSGYWLEYGGTFEQLQSAS 877
Cdd:COG3696    788 ----AQVPLSQVADIEVVEGPNQISRENGRRRIVVQANVRGRDLGSFVAEAQAKVAEQVKLPPGYYIEWGGQFENLQRAT 863
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  878 KRLSLVVPVTLLLIFGLLYSAFGSLRDSLIIFSGVPLALTGGVLALLLRDMPLSISAGVGFIALSGVAVLNGVVMLSFIK 957
Cdd:COG3696    864 ARLAIVVPLALLLIFLLLYLAFGSVRDALLILLNVPFALIGGVLALWLRGMPLSVSAGVGFIALFGVAVLNGVVLVSYIN 943
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1590405811  958 QLRNEGLSLYYAIHSGALQRLRPVLMTALVASLGFIPMALNTGTGAEIQRPLATVVVGGIMSST 1021
Cdd:COG3696    944 QLRAEGLDLREAIIEGALERLRPVLMTALVAALGLLPMALSTGPGSEVQRPLATVVIGGLITST 1007
2A0601 TIGR00914
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ...
1-1043 0e+00

heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129992 [Multi-domain]  Cd Length: 1051  Bit Score: 1335.94  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811    1 MINWIVSFAVKRRMMVLALTFLFAGFGVYNIQNLAVDAVPDITNVQVQINSKAPGFTPLEVEQRITYLVETAMAGIPKLD 80
Cdd:TIGR00914    1 MIERIISFSVAQRWLVLLATLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   81 YTRSLSRYGLSQVTIIFDEGTDIYWARQQIGERIQSIRADLPNNVEPNLGPIASGLGEIFTYSVHAKPDALKSDGMPYSA 160
Cdd:TIGR00914   81 TTRSLSRYGLSQVTVIFKDGTDLYFARQLVNERLQQARDNLPEGVSPEMGPISTGLGEIFLYTVEAEEGARKKDGGAYTL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  161 EDLRTLQDWVIRPQLLKVKGVTEINSQGGFERQYQVAPIPEKLIAYKLTIKDVITALELNNSNRGAGYIERFDGQYLVRS 240
Cdd:TIGR00914  161 TDLRTIQDWIIRPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRA 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  241 PGQLKTLADIANTVIAKRDDAPVRIKDVANVYLGKELRTGAATYNGEETVLGTAMMLIGENSRVVAKAMADKLIQVQKSL 320
Cdd:TIGR00914  241 PGQVQSMDDIRNIVIATGEGVPIRIRDVARVQIGKELRTGAATENGKEVVLGTVFMLIGENSRTVAQAVGDKLETINKTL 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  321 PAGVIVEPVYDRTNLVDKTIATVQKNLFEGAVLVIVILLLLLGNITGALITAMVIPLSMLFAITGMVGNRVSGNLMSLGA 400
Cdd:TIGR00914  321 PEGVEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSLGA 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  401 IDFGLIVDGAVIVVENCLRQLGMAQHKHGRLLTLSERLEVVTSATKEVFSPAVFGILIIMLVYLPLFALSGVEGKMFQPM 480
Cdd:TIGR00914  401 LDFGLIVDGAVVIVENAHRRLAEAQHHHGRQLTLKERLHEVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGKMFHPM 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  481 AFTVVAALIGALIFAVTFVPAAIAVFVRGKVDESENAVMRGVKKIYKPLLNLSLKLPWLMISIATVLVLVLGFKVKNMGA 560
Cdd:TIGR00914  481 AFTVVLALAGAMILSLTFVPAAVALFIRGKVAEKENRLMRVLKRRYEPLLERVLAWPAVVLGAAAVSIVLVVWIASRVGG 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  561 EFLPQLDEGDIAMHALRITGTGIEQSVQMQKQLEQALLAQPEIANVFSKIGTADVASDPMPPNVADTFLMLKPRAQWPDP 640
Cdd:TIGR00914  561 EFIPSLNEGDLAYQALRIPGTSLAQSVAMQQTLEKLIKSFPEVARVFAKTGTAEIATDPMPPNASDTYIILKPESQWPEG 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  641 SLSKDALVQRIRHRVNEVPGNNYEFTQPIEMRFNELIAGVRADVALRIYGDDLAILKQFGEKATSLMRNITGATDVRLEQ 720
Cdd:TIGR00914  641 KKTKEDLIEEIQEATVRIPGNNYEFTQPIQMRFNELISGVRSDVAVKVFGDDLDDLDATAEKISAVLKGVPGAADVKVEQ 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  721 MEGLPTLSVTPMRDHMALLGLTVNDIQQTLAAAVGGVQTGLIYEGDKRFSLLVRLDKRWSEDVSALARLPIALPQSSNPE 800
Cdd:TIGR00914  721 TTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRFDIVIRLPESLRESPQALRQLPIPLPLSEDAR 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  801 LAFVPLGEVATISIEKGPNQINRESGKRNVVVTANVAGRDLASFVRDAQATMNAQLNLPSGYWLEYGGTFEQLQSASKRL 880
Cdd:TIGR00914  801 KQFIPLSDVADLRVSPGPNQISRENGKRRVVVSANVRGRDLGSFVDDAKKAIAEQVKLPPGYWITWGGQFEQLQSATKRL 880
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  881 SLVVPVTLLLIFGLLYSAFGSLRDSLIIFSGVPLALTGGVLALLLRDMPLSISAGVGFIALSGVAVLNGVVMLSFIKQLR 960
Cdd:TIGR00914  881 QIVVPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMISFIRKLL 960
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  961 NEGLSLYYAIHSGALQRLRPVLMTALVASLGFIPMALNTGTGAEIQRPLATVVVGGIMSSTLLTLLILPALYKLVHGKFK 1040
Cdd:TIGR00914  961 EEGPSLDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQRPLATVVIGGIITATLLTLFVLPALYRLVHRRRH 1040

                   ...
gi 1590405811 1041 KQQ 1043
Cdd:TIGR00914 1041 KGR 1043
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
5-1036 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 950.58  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811    5 IVSFAVKRRMMVLALTFLFAGFGVYNIQNLAVDAVPDITNVQVQINSKAPGFTPLEVEQRITYLVETAMAGIPKLDYTRS 84
Cdd:pfam00873    1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   85 LSRYGLSQVTIIFDEGTDIYWARQQIGERIQSIRADLPNNV-EPNLGPIASGLGEIFTYsvhakpdALKSDGMPYSAEDL 163
Cdd:pfam00873   81 QSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGVqRPGISVIKTSLGPIMVL-------AVTSPDGSYTQTDL 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  164 RTLQDWVIRPQLLKVKGVTEINSQGGFERQYQVAPIPEKLIAYKLTIKDVITALELNNSNRGAGYIERFDGQYLVRSPGQ 243
Cdd:pfam00873  154 RDYADTNIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQ 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  244 LKTLADIANTVIAKRDDAPVRIKDVANVYLGKELRTGAATYNGEETVLGTAMMLIGENSRVVAKAMADKLIQVQKSLPAG 323
Cdd:pfam00873  234 LQSAEDFEKIIVKNQDGSPVRLRDVATVELGSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQG 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  324 VIVEPVYDRTNLVDKTIATVQKNLFEGAVLVIVILLLLLGNITGALITAMVIPLSMLFAITGMVGNRVSGNLMSLGAIDF 403
Cdd:pfam00873  314 VEIVVVYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVL 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  404 --GLIVDGAVIVVENCLRQLGMAQHKHgrlltlserLEVVTSATKEVFSPAVFGILIIMLVYLPLFALSGVEGKMFQPMA 481
Cdd:pfam00873  394 aiGLVVDDAIVVVENIERVLEENGLKP---------LEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFA 464
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  482 FTVVAALIGALIFAVTFVPAAIAVFVRGKVDESE-------NAVMRGVKKIYKPLLNLSLKLPWLMISIATVLVLVLGFK 554
Cdd:pfam00873  465 ITIVLAILLSVLVALTLTPALCATLLKPRREPKHggffrwfNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWL 544
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  555 VKNMGAEFLPQLDEGDIAMHALRITGTGIEQSVQMQKQLEQALLAQPEIANVFSKIGTADvASDPMPPNVADTFLMLKPR 634
Cdd:pfam00873  545 FVRIPTEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFAF-SGDNNGPNSGDAFISLKPW 623
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  635 AQWPDPSLSKDALVQRIRHRVNEVPGNNYEFTQPIEMRFNELIAGVRADVALRIYGDDLAILKQFGEKATSLMRNITGAT 714
Cdd:pfam00873  624 KERPGPEKSVQALIERLRKALKQIPGANVFLFQPIQLRGLGTISGFRSDLQVKIFGDDLDALDEARNQILAALAQLPGLS 703
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  715 DVRLEQMEGLPTLSVTPMRDHMALLGLTVNDIQQTLAAAVGGVQTGLIYEGDKRFSLLVRLDKRWSEDVSALARLPIalp 794
Cdd:pfam00873  704 DVRSDGQEDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYV--- 780
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  795 qsSNPELAFVPLGEVATISIEKGPNQINRESGKRNVVVTANVAGRDLASFVRDAQATMNAQLNLPSGYWLEYGGTFEQLQ 874
Cdd:pfam00873  781 --RNPYGKMIPLSAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVKLPPGYGYTWTGQFEQEQ 858
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  875 SASKRLSLVVPVTLLLIFGLLYSAFGSLRDSLIIFSGVPLALTGGVLALLLRDMPLSISAGVGFIALSGVAVLNGVVMLS 954
Cdd:pfam00873  859 LAGNSLPILIALALLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVE 938
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  955 FIKQLR-NEGLSLYYAIHSGALQRLRPVLMTALVASLGFIPMALNTGTGAEIQRPLATVVVGGIMSSTLLTLLILPALYK 1033
Cdd:pfam00873  939 FANELReQEGKSLEEAILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPVFYV 1018

                   ...
gi 1590405811 1034 LVH 1036
Cdd:pfam00873 1019 LFH 1021
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
4-1021 0e+00

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 685.68  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811    4 WIVSFAVKRRMMVLALTFLFAGFGVYNIQNLAVDAVPDITNVQVQINSKAPGFTPLEVEQRITYLVETAMAGIPKLDYTR 83
Cdd:COG0841      2 NLSRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYIT 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   84 SLSRYGLSQVTIIFDEGTDIYWARQQIGERIQSIRADLPNNVEPnlgPIasglgeIFTYSVHAKPD---ALKSDGMpySA 160
Cdd:COG0841     82 STSSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDLPEDVEP---PG------VTKVNPSDFPVmvlALSSDDL--DE 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  161 EDLRTLQDWVIRPQLLKVKGVTEINSQGGFERQYQVAPIPEKLIAYKLTIKDVITALELNNSNRGAGYIERFDGQYLVRS 240
Cdd:COG0841    151 LELSDYAERNIKDRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRT 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  241 PGQLKTLADIANTVIAKRDDAPVRIKDVANVYLGKELRTGAATYNGEETVLGTAMMLIGENSRVVAKAMADKLIQVQKSL 320
Cdd:COG0841    231 NGRLKTPEEFENIVIRTNDGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASL 310
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  321 PAGVIVEPVYDRTNLVDKTIATVQKNLFEGAVLVIVILLLLLGNITGALITAMVIPLSML--FAITGMVGnrVSGNLMSL 398
Cdd:COG0841    311 PEGVELTIVYDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIgtFAVMYLLG--FSLNILTL 388
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  399 GAIDF--GLIVDGAVIVVENCLRQlgMAQHKhgrlltlsERLEVVTSATKEVFSPAVFGILIIMLVYLPLFALSGVEGKM 476
Cdd:COG0841    389 FALVLaiGIVVDDAIVVVENIERH--MEEGL--------SPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQL 458
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  477 FQPMAFTVVAALIGALIFAVTFVPAAIAVFVRGKVDESE-------NAVMRGVKKIYKPLLNLSLKLPWLMISIATVLVL 549
Cdd:COG0841    459 FRQFALTVAIALLISLFVALTLTPALCARLLKPHPKGKKgrffrafNRGFDRLTRGYGRLLRWALRHRKLTLLVALALLA 538
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  550 VLGFKVKNMGAEFLPQLDEGDIAMHALRITGTGIEQSVQMQKQLEQALLAQPEIANVFSKIGTADVASDPmppNVADTFL 629
Cdd:COG0841    539 LSVLLFGRLPTEFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGGGSGS---NSGTIFV 615
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  630 MLKPraqWPDPSLSKDALVQRIRHRVNEVPGNNYEFTQPIEMRFneliaGVRADVALRIYGDDLAILKQFGEKATSLMRN 709
Cdd:COG0841    616 TLKP---WDERDRSADEIIARLREKLAKIPGARVFVFQPPAGGL-----GSGAPIEVQLQGDDLEELAAAAEKLLAALRQ 687
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  710 ITGATDVRLEQMEGLPTLSVTPMRDHMALLGLTVNDIQQTLAAAVGGVQTGLIYEGDKRFSLLVRLDKRWSEDVSALARL 789
Cdd:COG0841    688 IPGLVDVRSDLQLGKPELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENL 767
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  790 PIALPQSsnpelAFVPLGEVATISIEKGPNQINRESGKRNVVVTANVA-GRDLASFVRDAQATMnAQLNLPSGYWLEYGG 868
Cdd:COG0841    768 YVRTPDG-----EMVPLSSVATIEEGTGPSSINRYNGQRSVTVSANLApGVSLGEALAAIEELA-AELKLPPGVSIEFTG 841
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  869 TFEQLQSASKRLSLVVPVTLLLIFGLLYSAFGSLRDSLIIFSGVPLALTGGVLALLLRDMPLSISAGVGFIALSGVAVLN 948
Cdd:COG0841    842 QAEEEQESFSSLGLAFLLALLLVYLVLAAQFESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKN 921
                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1590405811  949 GVVMLSFIKQLRNEGLSLYYAIHSGALQRLRPVLMTALVASLGFIPMALNTGTGAEIQRPLATVVVGGIMSST 1021
Cdd:COG0841    922 AILLVDFANQLREEGMSLREAILEAARLRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFST 994
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
10-1021 1.85e-123

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 402.09  E-value: 1.85e-123
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   10 VKRRMMVLALTFLFAGFGVYNIQNLAVDAVPDITNVQVQINSKAPGFTPLEVEQRITYLVETAMAGIPKLDYTRSLSRYG 89
Cdd:NF033617     5 IKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQSSLG 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   90 LSQVTIIFDEGTDIYWARQQIGERIQSIRADLPNN-----VEPNLGPIASGLGEIftysvhakpdALKSDGMPYSAedLR 164
Cdd:NF033617    85 YSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEapdppVYRKANSADTPIMYI----------GLTSEEMPRGQ--LT 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  165 TLQDWVIRPQLLKVKGVTEINSQGGFERQYQVAPIPEKLIAYKLTIKDVITALELNNSNRGAGYIERFDGQYLVRSPGQL 244
Cdd:NF033617   153 DYAERVLAPKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQL 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  245 KTLADIANTVIAKRDD-APVRIKDVANVYLGKELRTGAATYNGEETVLGTAMMLIGENSRVVAKAMADKLIQVQKSLPAG 323
Cdd:NF033617   233 KTAEDYEDLVIKYADNgAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLPKN 312
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  324 VIVEPVYDRTNLVDKTIATVQKNLFEGAVLVIVILLLLLGNITGALITAMVIPLSMLFAITGMVGNRVSGNLMSLGA--I 401
Cdd:NF033617   313 IKVNVLYDRTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMAlvL 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  402 DFGLIVDGAVIVVENCLRQL--GMAQhkhgrlltlserLEVVTSATKEVFSPAVFGILIIMLVYLPLFALSGVEGKMFQP 479
Cdd:NF033617   393 AIGLVVDDAIVVVENIHRHIeeGESP------------LEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFRE 460
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  480 MAFTVVAALIGALIFAVTFVPAAIAVFVRGKVDESENA-----VMRGVKKIYKPLLNLSLKLPWLMISIA--TVLVLVLG 552
Cdd:NF033617   461 FAVTLAGAVIISGIVALTLTPMMCSRLLKANEKPGRFAravdrFFDGLTARYGRGLKWVLKHRPLTLVVAlaTLALLPLL 540
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  553 FKVknMGAEFLPQLDEGDIAMHALRITGTGIEQSVQMQKQLEQALLAQPEIANVFSKIGTADVASDpmppNVADTFLMLK 632
Cdd:NF033617   541 YVF--IPKELAPSEDRGVIFGMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTSFNGVGGNPGD----NTGFGIINLK 614
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  633 PraqWPDPSLSKDALVQRIRHRVNEVPGnnyefTQPIEMRFNELIAGVRADVALRIY---GDDLAILKQFGEKATSLMRN 709
Cdd:NF033617   615 P---WDERDVSAQEIIDRLRPKLAKVPG-----MDLFLFPLQDLPGGAGSSLPQYQVtltPSDYDSLFTWAEKLKEKLRK 686
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  710 ITGATDVRLEQMEGLPTLSVTPMRDHMALLGLTVNDIQQTLAAAVGGVQTGLIYEGDKRFSLLVRLDKRWSEDVSALARL 789
Cdd:NF033617   687 SPQFADVDSDLQDKGPELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQI 766
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  790 PIalpQSSNPELafVPLGEVATISIEKGPNQINRESGKRNVVVTANVA-GRDLASFVrdaQATMN-AQLNLPSGYWLEYG 867
Cdd:NF033617   767 YV---RSNDGKL--VPLSTLAKIEERAAPLSLNHFNQFNSATLSFNLApGVSLGEAI---EALDQaAKELLPSGISGSFQ 838
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  868 GTFEQLQSASKRLSLVVPVTLLLIFGLLYSAFGSLRDSLIIFSGVPLALTGGVLALLLRDMPLSISAGVGFIALSGVAVL 947
Cdd:NF033617   839 GAARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKK 918
                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1590405811  948 NGVVMLSFIKQL-RNEGLSLYYAIHSGALQRLRPVLMTALVASLGFIPMALNTGTGAEIQRPLATVVVGGIMSST 1021
Cdd:NF033617   919 NGILMVEFANELqRHQGLSRREAIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGT 993
2A0602 TIGR00915
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ...
16-1044 1.01e-81

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]


Pssm-ID: 273335 [Multi-domain]  Cd Length: 1044  Bit Score: 287.78  E-value: 1.01e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   16 VLALTFLFAGfgVYNIQNLAVDAVPDITNVQVQINSKAPGFTPLEVEQRITYLVETAMAGIPKLDYTRSLSRY-GLSQVT 94
Cdd:TIGR00915   14 VIAIIIMLAG--TLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSSSSDSdGSMTIT 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   95 IIFDEGTDIYWARQQIGERIQSIRADLPNNVEpNLGPIASGLGEIFTYSVhakpdALKSDGMPYSAEDLRTLQDWVIRPQ 174
Cdd:TIGR00915   92 LTFEQGTDPDIAQVQVQNKLQLATPLLPQEVQ-RQGVRVEKASSNFLMVI-----GLVSDDGSMTKEDLSDYAASNMVDP 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  175 LLKVKGVTEINSQGGfERQYQVAPIPEKLIAYKLTIKDVITALELNNSNRGAGYI---ERFDGQYL---VRSPGQLKTLA 248
Cdd:TIGR00915  166 LSRLEGVGDVQLFGS-QYAMRIWLDPAKLNSYQLTPADVISAISAQNAQISAGQLgglPAVPGQQLnatIIAQTRLQTPE 244
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  249 DIANTVI-AKRDDAPVRIKDVANVYLGKELRTGAATYNGEETVlGTAMML-IGENSRVVAKAMADKLIQVQKSLPAGVIV 326
Cdd:TIGR00915  245 QFENILLkVNTDGSQVRLKDVARVELGGENYSISARFNGKPAS-GLAIKLaTGANALDTAKAVKAELAVLEPFFPQGMKY 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  327 EPVYDRTNLVDKTIATVQKNLFEGAVLVIVILLLLLGNITGALITAMVIPLSML--FAITGMVGNRVSGNLMSLGAIDFG 404
Cdd:TIGR00915  324 VYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLgtFAVLAAFGFSINTLTMFAMVLAIG 403
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  405 LIVDGAVIVVENCLRqlgmaqhkhgrllTLSERLEVVTSATKEVF---SPAVFGI-LIIMLVYLPLFALSGVEGKMFQPM 480
Cdd:TIGR00915  404 LLVDDAIVVVENVER-------------VMAEEGLPPKEATRKSMgqiQGALVGIaMVLSAVFVPMAFFGGSTGAIYRQF 470
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  481 AFTVVAALIGALIFAVTFVPAAIAVFVRG-------------------KVDESENAVMRGVKKIykpllnLSLKLPWLMI 541
Cdd:TIGR00915  471 SITIVSAMALSVLVALILTPALCATMLKPiekgehhekkggffgwfnrMFDSSTHGYENGVGKI------LRRRGRYLLV 544
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  542 SIatVLVLVLGFKVKNMGAEFLPQLDEGDIAMHALRITGTGIEQSVQMQKQLEQALLAQP--EIANVFSKIGTADVASDp 619
Cdd:TIGR00915  545 YV--LLVGGMVFLFVRLPTSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLLAKEkaNVESVFTVNGFSFAGRG- 621
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  620 mpPNVADTFLMLKPRAQWPDPSLSKDALVQRIRHRVNEVP-GNNYEFTQPiemRFNELIAGVRADVALRIY-GDDLAILK 697
Cdd:TIGR00915  622 --QNMGMAFIRLKDWEERTGKENSVFAIAGRATGHFMQIKdAMVIAFVPP---AILELGNATGFDFFLQDRaGLGHEALL 696
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  698 QFGEKATSLMRNITGATDVRLEQMEGLPTLSVTPMRDHMALLGLTVNDIQQTLAAAVGGVQTG-LIYEGD-KRFSLLVRL 775
Cdd:TIGR00915  697 QARNQLLGLAAQNPALTRVRPNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNdFIDRGRvKRVYVQAEE 776
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  776 DKRWSEDVSALARLPIALPQssnpelaFVPLGEVATISIEKGPNQINRESGKRNVVVTANVAGRDLASFVRDAQATMNAQ 855
Cdd:TIGR00915  777 DARMSPEDINKWYVRNASGE-------MVPFSAFATVRWEYGSPQLERYNGLPSMEILGSAAPGVSTGQAMAAMEAIAQK 849
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  856 lnLPSGYWLEYGG-TFEQLQSASKRLSLVVpVTLLLIFGLLYSAFGSLRDSLIIFSGVPLALTGGVLALLLRDMPLSISA 934
Cdd:TIGR00915  850 --LPPGFGFSWTGmSYEERLSGSQAPALYA-LSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRGLSNDVYF 926
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  935 GVGFIALSGVAVLNGVVMLSFIKQLRNEGLSLYYAIHSGALQRLRPVLMTALVASLGFIPMALNTGTGAEIQRPLATVVV 1014
Cdd:TIGR00915  927 QVGLLTTIGLSAKNAILIVEFAKELMAQGKSIVEAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGSQHAIGTGVF 1006
                         1050      1060      1070
                   ....*....|....*....|....*....|
gi 1590405811 1015 GGIMSSTLLTLLILPALYKLVHGKFKKQQT 1044
Cdd:TIGR00915 1007 GGMVTATVLAIFFVPLFYVVVRRLFKRKAH 1036
PRK09577 PRK09577
multidrug efflux RND transporter permease subunit;
16-1021 2.20e-64

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169981 [Multi-domain]  Cd Length: 1032  Bit Score: 236.67  E-value: 2.20e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   16 VLALTFLFAGfgVYNIQNLAVDAVPDITNVQVQINSKAPGFTPLEVEQRITYLVETAMAGIPKLDYTRSLSRYGLSQVTI 95
Cdd:PRK09577    14 VISLFIMLGG--IFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSATSSAGQASLSL 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   96 IFDEGTDIYWARQQIGERIQSIRADLPNNVEPNlGPIASGLGEIFTYSVhakpdALKSDGMPYSAEDLRTLQDWVIRPQL 175
Cdd:PRK09577    92 TFKQGVNADLAAVEVQNRLKTVEARLPEPVRRD-GIQVEKAADNIQLIV-----SLTSDDGRLTGVELGEYASANVLQAL 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  176 LKVKGVTEINSQGGfERQYQVAPIPEKLIAYKLTIKDVITALELNNSNRGAGYIERF---DGQYL---VRSPGQLKTLAD 249
Cdd:PRK09577   166 RRVEGVGKVQFWGA-EYAMRIWPDPVKLAALGLTASDIASAVRAHNARVTIGDIGRSavpDSAPIaatVFADAPLKTPED 244
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  250 IANTVI-AKRDDAPVRIKDVANVYLGKELRTGAATYNGEETVLGTAMMLIGENSRVVAKAMADKLIQVQKSLPAGVIVEP 328
Cdd:PRK09577   245 FGAIALrARADGSALYLRDVARIEFGGNDYNYPSYVNGKTATGMGIKLAPGSNAVATEKRVRATMDELSRYFPPGVKYQI 324
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  329 VYDRTNLVDKTIATVQKNLFEGAVLVIVILLLLLGNITGALITAMVIPLSMLFAITGMVGNRVSGNLMSL--GAIDFGLI 406
Cdd:PRK09577   325 PYETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGFSINVLTMfgMVLAIGIL 404
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  407 VDGAVIVVENCLRqlgmaqhkhgrlLTLSERL---EVVTSATKEVfSPAVFGILIIML-VYLPLFALSGVEGKMFQPMAF 482
Cdd:PRK09577   405 VDDAIVVVENVER------------LMVEEGLspyDATVKAMKQI-SGAIVGITVVLTsVFVPMAFFGGAVGNIYRQFAL 471
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  483 TVVAALIGALIFAVTFVPAAIAVFVRGKVDESEN----------AVMRGVKKiYKPLLNLSLKLP--WLMISIATVLVLV 550
Cdd:PRK09577   472 SLAVSIGFSAFLALSLTPALCATLLKPVDGDHHEkrgffgwfnrFVARSTQR-YATRVGAILKRPlrWLVVYGALTAAAA 550
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  551 LGFkvKNMGAEFLPQLDEGDIAMHALRITGTGIEQSVQMQKQLEQALLAQPEIANVFSkIGTADVASDpmPPNVADTFLM 630
Cdd:PRK09577   551 LLF--TRLPTAFLPDEDQGNFMVMVIRPQGTPLAETMQSVREVESYLRRHEPVAYTFA-LGGFNLYGE--GPNGGMIFVT 625
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  631 LKPRAQWPDPSLSKDALVQRIRHRVNEVPGNN-YEFTQPiemRFNELIAGVRADVALRIYGD-DLAILKQFGEKATSLMR 708
Cdd:PRK09577   626 LKDWKERKAARDHVQAIVARINERFAGTPNTTvFAMNSP---ALPDLGSTSGFDFRLQDRGGlGYAAFVAAREQLLAEGA 702
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  709 NITGATDVRLEQMEGLPTLSVTPMRDHMALLGLTVNDIQQTLAAAVGGVQTGLIYEGDKRFSLLVRLDKRWSEDVSALAR 788
Cdd:PRK09577   703 KDPALTDLMFAGTQDAPQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGDFMHGSQVRRVIVQADGRHRLDPDDVKK 782
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  789 LPIalpQSSNPELafVPLGEVATISIEKGPNQINRESGKRNVVVTANVA-----GRDLASFVRDAQatmnaqlNLPSGYW 863
Cdd:PRK09577   783 LRV---RNAQGEM--VPLAAFATLHWTLGPPQLTRYNGYPSFTINGSAApghssGEAMAAIERIAA-------TLPAGIG 850
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  864 LEYGGtfeqlQSASKRLS-----LVVPVTLLLIFGLLYSAFGSLRDSLIIFSGVPLALTGGVLALLLRDMPLSISAGVGF 938
Cdd:PRK09577   851 YAWSG-----QSFEERLSgaqapMLFALSVLVVFLALAALYESWSIPFAVMLVVPLGVIGAVLGVTLRGMPNDIYFKVGL 925
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  939 IALSGVAVLNGVVMLSFIKQLRNEGLSLYYAIHSGALQRLRPVLMTALVASLGFIPMALNTGTGAEIQRPLATVVVGGIM 1018
Cdd:PRK09577   926 IATIGLSAKNAILIVEVAKDLVAQRMSLADAALEAARLRLRPIVMTSLAFGVGVLPLAFASGAASGAQIAIGTGVLGGVI 1005

                   ...
gi 1590405811 1019 SST 1021
Cdd:PRK09577  1006 TAT 1008
PRK10555 PRK10555
multidrug efflux RND transporter permease AcrD;
7-1039 2.39e-63

multidrug efflux RND transporter permease AcrD;


Pssm-ID: 182544 [Multi-domain]  Cd Length: 1037  Bit Score: 233.57  E-value: 2.39e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811    7 SFAVKRRMMVLALTFLFAGFGVYNIQNLAVDAVPDITNVQVQINSKAPGFTPLEVEQRITYLVETAMAGIPKLDYTRSLS 86
Cdd:PRK10555     3 NFFIDRPIFAWVLAILLCLTGTLAIFSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQS 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   87 RY-GLSQVTIIFDEGTDIYWARQQIGERIQSIRADLPNNVEpNLGPIASGLGE--IFTYSVhakpdaLKSDGmpysAEDL 163
Cdd:PRK10555    83 SGtGQASVTLSFKAGTDPDEAVQQVQNQLQSAMRKLPQAVQ-NQGVTVRKTGDtnILTIAF------VSTDG----SMDK 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  164 RTLQDWV---IRPQLLKVKGVTEINSQGGferQY--QVAPIPEKLIAYKLTIKDVITALELNNSNRGAGYI--------- 229
Cdd:PRK10555   152 QDIADYVasnIQDPLSRVNGVGDIDAYGS---QYsmRIWLDPAKLNSFQMTTKDVTDAIESQNAQIAVGQLggtpsvdkq 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  230 ---ERFDGQYLVRSPGQLKTLadianTVIAKRDDAPVRIKDVANVYLGKELRTGAATYNGEETVLGTAMMLIGENSRVVA 306
Cdd:PRK10555   229 alnATINAQSLLQTPEQFRDI-----TLRVNQDGSEVTLGDVATVELGAEKYDYLSRFNGKPASGLGVKLASGANEMATA 303
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  307 KAMADKLIQVQKSLPAGVIVEPVYDRTNLVDKTIATVQKNLFEGAVLVIVILLLLLGNITGALITAMVIPLSML--FAIT 384
Cdd:PRK10555   304 KLVLNRLDELAQYFPHGLEYKVAYETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMgtFSVL 383
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  385 GMVGNRVSGNLMSLGAIDFGLIVDGAVIVVENCLRQlgMAQHKhgrlltLSERlevvtSATKEVFSP---AVFGI-LIIM 460
Cdd:PRK10555   384 YAFGYSINTLTMFAMVLAIGLLVDDAIVVVENVERI--MSEEG------LTPR-----EATRKSMGQiqgALVGIaMVLS 450
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  461 LVYLPLFALSGVEGKMFQPMAFTVVAALIGALIFAVTFVPAAIAVFVR--------GK----------VDESENAVMRGV 522
Cdd:PRK10555   451 AVFVPMAFFGGTTGAIYRQFSITIVSAMVLSVLVAMILTPALCATLLKplkkgehhGQkgffgwfnrmFNRNAERYEKGV 530
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  523 KKIykpllnLSLKLPWLMISIATVLVLVLGFkvKNMGAEFLPQLDEGDIAMHALRITGTGIEQSVQMQKQLEQALLAQPE 602
Cdd:PRK10555   531 AKI------LHRSLRWILIYVLLLGGMVFLF--LRLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEKVEKYYFTHEK 602
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  603 --IANVFSKIGTADVASDpmpPNVADTFLMLKPRAQWPDPSLSKDALVQRIR---HRVNEVP------------GNNYEF 665
Cdd:PRK10555   603 dnVMSVFATVGSGPGGNG---QNVARMFIRLKDWDERDSKTGTSFAIIERATkafNKIKEARviassppaisglGSSAGF 679
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  666 TQPIEMRFNeliAGVRADVALRiygddlAILKQFGEKATSLMRnitgatdVRLEQMEGLPTLSVTPMRDHMALLGLTVND 745
Cdd:PRK10555   680 DMELQDHAG---AGHDALMAAR------NQLLALAAKNPELTR-------VRHNGLDDSPQLQIDIDQRKAQALGVSIDD 743
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  746 IQQTLAAAVGGVqtgliYEGDkrFSLLVRLDKRWSEDVSALARLP--IALPQSSNPELAFVPLGEVATISIEKGPNQINR 823
Cdd:PRK10555   744 INDTLQTAWGSS-----YVND--FMDRGRVKKVYVQAAAPYRMLPddINLWYVRNKDGGMVPFSAFATSRWETGSPRLER 816
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  824 ESGKRNVVVTANVAGRDLASFVRDAQATMNAQlnLPSGYWLEYGGTFEQLQSASKRLSLVVPVTLLLIFGLLYSAFGSLR 903
Cdd:PRK10555   817 YNGYSAVEIVGEAAPGVSTGTAMDIMESLVKQ--LPNGFGLEWTAMSYQERLSGAQAPALYAISLLVVFLCLAALYESWS 894
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  904 DSLIIFSGVPLALTGGVLALLLRDMPLSISAGVGFIALSGVAVLNGVVMLSFIKQLRNEGLSLYYAIHSGALQRLRPVLM 983
Cdd:PRK10555   895 VPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANEMNQKGHDLFEATLHASRQRLRPILM 974
                         1050      1060      1070      1080      1090
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1590405811  984 TALVASLGFIPMALNTGTGAEIQRPLATVVVGGIMSSTLLTLLILPALYKLVHGKF 1039
Cdd:PRK10555   975 TSLAFIFGVLPMATSTGAGSGSQHAVGTGVMGGMISATILAIFFVPLFFVLVRRRF 1030
PRK10614 PRK10614
multidrug efflux system subunit MdtC; Provisional
27-1020 3.97e-58

multidrug efflux system subunit MdtC; Provisional


Pssm-ID: 182589 [Multi-domain]  Cd Length: 1025  Bit Score: 217.67  E-value: 3.97e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   27 GVYNIQNLAVDAVPDITNVQVQINSKAPGFTPLEVEQRITYLVETAMAGIPKLDYTRSLSRYGLSQVTIIFDEGTDIYWA 106
Cdd:PRK10614    25 GILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSSSLGSTRIILQFDFDRDINGA 104
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  107 RQQIGERIQSIRADLPNN---------VEPNLGPIAsglgeIFTysvhakpdaLKSDgmPYSAEDLRTLQDWVIRPQLLK 177
Cdd:PRK10614   105 ARDVQAAINAAQSLLPSGmpsrptyrkANPSDAPIM-----ILT---------LTSD--TYSQGQLYDFASTQLAQTISQ 168
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  178 VKGVTEINSQGGFERQYQVAPIPEKLIAYKLTIKDVITALELNNSNRGAGYIERFDGQYLVRSPGQLKTLADIANTVIAK 257
Cdd:PRK10614   169 IDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRQAISNANVRRPQGAVEDGTHRWQIQTNDELKTAAEYQPLIIHY 248
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  258 RDDAPVRIKDVANVYLGKELRTGAATYNGEETVLGTAMMLIGENSRVVAKAMADKLIQVQKSLPAGVIVEPVYDRTNLVD 337
Cdd:PRK10614   249 NNGAAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDRIRAKLPELRETIPAAIDLQIAQDRSPTIR 328
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  338 KTIATVQKNLFEGAVLVIVILLLLLGNITGALITAMVIPLSMLFAITGMVGNRVSGNLMSLGA--IDFGLIVDGAVIVVE 415
Cdd:PRK10614   329 ASLEEVEQTLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMAltIATGFVVDDAIVVLE 408
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  416 NCLRQL--GMaqhkhgrlltlsERLEVVTSATKEVFSPAVFGILIIMLVYLPLFALSGVEGKMFQPMAFTVVAALIGALI 493
Cdd:PRK10614   409 NISRHLeaGM------------KPLQAALQGVREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLFREFAVTLSVAIGISLL 476
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  494 FAVTFVPAAIAVFVRGKVDESE----------NAVMRGVKKIYKPLLNLSlklPWLMISIATVLVLVLGFKVkNMGAEFL 563
Cdd:PRK10614   477 VSLTLTPMMCAWLLKSSKPREQkrlrgfgrmlVALQQGYGRSLKWVLNHT---RWVGVVLLGTIALNVWLYI-SIPKTFF 552
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  564 PQLDEGdiamhalRITGtGI--EQSVQMQ------KQLEQALLAQPEIANVFSKIGTADVASDPMppnvadtFLMLKPRA 635
Cdd:PRK10614   553 PEQDTG-------RLMG-FIqaDQSISFQamrgklQDFMKIIRDDPAVDNVTGFTGGSRVNSGMM-------FITLKPLS 617
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  636 QWPDpslSKDALVQRIRHRVNEVPGNNYeFTQPIEmrfnELIAGVRADVALRIY---GDDLAILKQFGEKATSLMRNITG 712
Cdd:PRK10614   618 ERSE---TAQQVIDRLRVKLAKEPGANL-FLMAVQ----DIRVGGRQSNASYQYtllSDDLAALREWEPKIRKALAALPE 689
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  713 ATDVRLEQMEGLPTLSVTPMRDHMALLGLTVNDIQQTLAAAVGGVQTGLIYEGDKRFSLLVRLDKRWSEDVSALARLPIA 792
Cdd:PRK10614   690 LADVNSDQQDKGAEMALTYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPLNQYKVVMEVDPRYTQDISALEKMFVI 769
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  793 lpqssNPELAFVPLGEVATISIEKGPNQINRESGKRNVVVTANVA-GRDLASFVRDAQATMnAQLNLPSGYWLEYGGT-- 869
Cdd:PRK10614   770 -----NNEGKAIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLPtGKSLSDASAAIERAM-TQLGVPSTVRGSFAGTaq 843
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  870 -FEQLQSASKRLSLVVPVTLLLIFGLLYSafgSLRDSLIIFSGVPLALTGGVLALLLRDMPLSISAGVGFIALSGVAVLN 948
Cdd:PRK10614   844 vFQETMNSQLILILAAIATVYIVLGILYE---SYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKN 920
                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1590405811  949 GVVMLSF-IKQLRNEGLSLYYAIHSGALQRLRPVLMTALVASLGFIPMALNTGTGAEIQRPLATVVVGGIMSS 1020
Cdd:PRK10614   921 AIMMVDFaLEAQRNGNLTAQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGAELRQPLGITIVGGLVMS 993
PRK09579 PRK09579
multidrug efflux RND transporter permease subunit;
15-1045 7.63e-56

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169983 [Multi-domain]  Cd Length: 1017  Bit Score: 210.85  E-value: 7.63e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   15 MVLALTFLFAGFGVYNiqNLAVDAVPDITNVQVQINSKAPGFTPLEVEQRITYLVETAMAGIPKLDYTRSLSRYGLSQVT 94
Cdd:PRK09579    15 SVVSLLIVLLGFQAWS--KLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYMTSVSRQNFSIIS 92
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   95 IIFDEGTDIYWARQQIGERIQSIRADLPNNVE-PNLGPIASglgeiftysvhakpDALKSDGMPYSAEDLRTLQ--DW-- 169
Cdd:PRK09579    93 IYARIGADSDRLFTELLAKANEVKNQLPQDAEdPVLSKEAA--------------DASALMYISFYSEEMSNPQitDYls 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  170 -VIRPQLLKVKGVTEINSQGGFERQYQVAPIPEKLIAYKLTIKDVITALELNNSNRGAGYIErfdGQYLVRS---PGQLK 245
Cdd:PRK09579   159 rVIQPKLATLPGMAEAEILGNQVFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEVK---GEYVVTSinaSTELK 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  246 TLADIANTVIAKRDDAPVRIKDVANVYLGKELRTGAATYNGEETVLGTAMMLIGENSRVVAKAMADKLIQVQKSLPAGVI 325
Cdd:PRK09579   236 SAEAFAAIPVKTSGDSRVLLGDVARVEMGAENYDSISSFDGIPSVYIGIKATPSANPLDVIKEVRAIMPELESQLPPNLK 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  326 VEPVYDRTNLVDKTIATVQKNLFEGAVLVIVILLLLLGNITGALITAMVIPLSMLFAITGMVGNRVSGNLMSLGA--IDF 403
Cdd:PRK09579   316 VSIAYDATLFIQASIDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLLAmvLAI 395
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  404 GLIVDGAVIVVENCLRQLgmaqhKHGRlltlsERLEVVTSATKEVFSPAVFGILIIMLVYLPLFALSGVEGKMFQPMAFT 483
Cdd:PRK09579   396 GLVVDDAIVVVENIHRHI-----EEGK-----SPFDAALEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALFKEFALT 465
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  484 VVAALIGALIFAVTFVPAAIAVFVRGKVDESENA-----VMRGVKKIYKPLLNLSLKLPWLMISIATVLVLVLGFKVKNM 558
Cdd:PRK09579   466 LAGAVIISGIVALTLSPMMCALLLRHEENPSGLAhrldrLFERLKQRYQRALHGTLNTRPVVLVFAVIVLALIPVLLKFT 545
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  559 GAEFLPQLDEGDIAMHALRITGTGIEQSVQMQKQLEQALLAQPEIANVFSKIGTADVASDpmppnvADTFLmLKPraqWP 638
Cdd:PRK09579   546 QSELAPEEDQGIIFMMSSSPQPANLDYLNAYTDEFTPIFKSFPEYYSSFQINGFNGVQSG------IGGFL-LKP---WN 615
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  639 DPSLSKDALVQRIRHRVNEVPG-NNYEFTQPIEMRFNEliaGVRADVALRIYGDDLAILkQFGEKATSLMRNITGATDVR 717
Cdd:PRK09579   616 ERERTQMELLPLVQAKLEEIPGlQIFGFNLPSLPGTGE---GLPFQFVINTANDYESLL-QVAQRVKQRAQESGKFAFLD 691
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  718 LEQMEGLPTLSVTPMRDHMALLGLTVNDIQQTLAAAVGgvqtgliyEGD-KRFSLLVRLDKRWSEDVSALARLPIALPQ- 795
Cdd:PRK09579   692 IDLAFDKPEVVVDIDRAKAAQMGVSMQDLGGTLATLLG--------EGEiNRFTIDGRSYKVIAQVERPYRDNPGWLNNy 763
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  796 -SSNPELAFVPLGEVATISIEKGPNQINrESGKRNVVVTANVAGRDLASFVRDAQATmnAQLNLPSGYWLEYGGTFEQLQ 874
Cdd:PRK09579   764 yVKNEQGQLLPLSTLITLSDRARPRQLN-QFQQLNSAIISGFPIVSMGEAIETVQQI--AREEAPEGFAFDYAGASRQYV 840
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  875 SASKRLSLVVPVTLLLIFGLLYSAFGSLRDSLIIFSGVPLALTGGVLALLLRDMPLSISAGVGFIALSGVAVLNGVVMLS 954
Cdd:PRK09579   841 QEGSALWVTFGLALAIIFLVLAAQFESFRDPLVILVTVPLSICGALIPLFLGVSSMNIYTQVGLVTLIGLISKHGILIVE 920
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  955 FIKQLRNE-GLSLYYAIHSGALQRLRPVLMTALVASLGFIPMALNTGTGAEIQRPLATVVVGGIMSSTLLTLLILPALYK 1033
Cdd:PRK09579   921 FANQLRHEqGLSRREAIEEAAAIRLRPVLMTTAAMVFGMVPLILATGAGAVSRFDIGLVIATGMSIGTLFTLFVLPCIYT 1000
                         1050
                   ....*....|..
gi 1590405811 1034 LVHGKFKKQQTA 1045
Cdd:PRK09579  1001 LLAKPDAAPGVA 1012
PRK10503 PRK10503
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
16-1020 4.14e-51

MdtB/MuxB family multidrug efflux RND transporter permease subunit;


Pssm-ID: 182501 [Multi-domain]  Cd Length: 1040  Bit Score: 196.10  E-value: 4.14e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   16 VLALTFLFAGFGVYNIqnLAVDAVPDITNVQVQINSKAPGFTPLEVEQRITYLVETAMAGIPKLDYTRSLSRYGLSQVTI 95
Cdd:PRK10503    25 LLMVAILLAGIIGYRA--LPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITL 102
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   96 IFDEGTDIYWARQQIGERIQSIRADLPNNVePNLgPIASGLGE----IFTYSVhakpdalKSDGMPysaedLRTLQDWV- 170
Cdd:PRK10503   103 QFQLTLPLDVAEQEVQAAINAATNLLPSDL-PNP-PVYSKVNPadppIMTLAV-------TSTAMP-----MTQVEDMVe 168
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  171 --IRPQLLKVKGVTEINSQGGFERQYQVAPIPEKLIAYKLTIKDVITALELNNSNRGAGYIERFDGQYLVRSPGQLKTLA 248
Cdd:PRK10503   169 trVAQKISQVSGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPTRAVTLSANDQMQSAE 248
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  249 DIANTVIAKRDDAPVRIKDVANVYLGKELRTGAATYNGEETVLGTAMMLIGENSRVVAKAMADKLIQVQKSLPAGVIVEP 328
Cdd:PRK10503   249 EYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIATADSIRQMLPQLTESLPKSVKVTV 328
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  329 VYDRTNLVDKTIATVQKNLFEGAVLVIVILLLLLGNITGALITAMVIPLSML--FAITGMVGNRVSG-NLMSLgAIDFGL 405
Cdd:PRK10503   329 LSDRTTNIRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIgtFAVMVFLDFSINNlTLMAL-TIATGF 407
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  406 IVDGAVIVVENCLRQLgmaqhkhgrlltlsERLEV-VTSATKevfSPAVFGILIIML------VYLPLFALSGVEGKMFQ 478
Cdd:PRK10503   408 VVDDAIVVIENISRYI--------------EKGEKpLAAALK---GAGEIGFTIISLtfsliaVLIPLLFMGDIVGRLFR 470
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  479 PMAFTV-VAALIGALIfAVTFVPAAIAVFVRGKVDESENAVMRGVKK-------IYKPLLNLSLKLPWLMISIA--TVLV 548
Cdd:PRK10503   471 EFAVTLaVAILISAVV-SLTLTPMMCARMLSQESLRKQNRFSRASERmfdrviaAYGRGLAKVLNHPWLTLSVAlsTLLL 549
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  549 LVLGFKVKNMGaeFLPQLDEGDIAMHALRITGTGIEQSVQMQKQLEQALLAQPEIANVFSKIGTadvasDPMPP--NVAD 626
Cdd:PRK10503   550 TVLLWIFIPKG--FFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGV-----DGTNPslNSAR 622
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  627 TFLMLKPRAQWPDpslSKDALVQRIRHRVNEVPGNNYeFTQPIE-MRFNELIAgvRADVALRIYGDDLAILKQFGEKATS 705
Cdd:PRK10503   623 LQINLKPLDERDD---RVQKVIARLQTAVAKVPGVDL-YLQPTQdLTIDTQVS--RTQYQFTLQATSLDALSTWVPKLME 696
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  706 LMRNITGATDVRLEQMEGLPTLSVTPMRDHMALLGLTVNDIQQTLAAAVGGVQTGLIYEGDKRFSLLVRLDKRWSEDVSA 785
Cdd:PRK10503   697 KLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAA 776
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  786 LARlpIALPQSSNpelAFVPLGEVATISIEKGPNQINRESGKRNVVVTANVAgrDLASFVRDAQATMNAQ--LNLPSGYW 863
Cdd:PRK10503   777 LDT--IRLTSSDG---GVVPLSSIATIEQRFGPLSINHLDQFPSTTISFNVP--DGYSLGDAVQAIMDTEktLNLPADIT 849
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  864 LEYGGTFEQLQSA-SKRLSLVVP--VTLLLIFGLLYSAFgslRDSLIIFSGVPLALTGGVLALLLRDMPLSISAGVGFIA 940
Cdd:PRK10503   850 TQFQGSTLAFQSAlGSTVWLIVAavVAMYIVLGVLYESF---IHPITILSTLPTAGVGALLALMIAGSELDVIAIIGIIL 926
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  941 LSGVAVLNGVVMLSF-IKQLRNEGLSLYYAIHSGALQRLRPVLMTALVASLGFIPMALNTGTGAEIQRPLATVVVGGIMS 1019
Cdd:PRK10503   927 LIGIVKKNAIMMIDFaLAAEREQGMSPRDAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGICMVGGLIV 1006

                   .
gi 1590405811 1020 S 1020
Cdd:PRK10503  1007 S 1007
PRK15127 PRK15127
multidrug efflux RND transporter permease subunit AcrB;
16-1042 3.59e-50

multidrug efflux RND transporter permease subunit AcrB;


Pssm-ID: 185081 [Multi-domain]  Cd Length: 1049  Bit Score: 193.20  E-value: 3.59e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   16 VLALTFLFAGfgVYNIQNLAVDAVPDITNVQVQINSKAPGFTPLEVEQRITYLVETAMAGIPKLDYTRSLS-RYGLSQVT 94
Cdd:PRK15127    14 VIAIIIMLAG--GLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSdSTGTVQIT 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811   95 IIFDEGTDIYWARQQIGERIQSIRADLPNNVEpnlgpiASGLGEIFTYSVHAKPDALKSDGMPYSAEDLRTLQDWVIRPQ 174
Cdd:PRK15127    92 LTFESGTDADIAQVQVQNKLQLAMPLLPQEVQ------QQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDP 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  175 LLKVKGVTEINSqggFERQY--QVAPIPEKLIAYKLTIKDVITALELNNSNRGAGyieRFDGQYLVrsPGQLKTLADIAN 252
Cdd:PRK15127   166 ISRTSGVGDVQL---FGSQYamRIWMNPNELNKFQLTPVDVINAIKAQNAQVAAG---QLGGTPPV--KGQQLNASIIAQ 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  253 TVIA------------KRDDAPVRIKDVANVYLGKELRTGAATYNGEETVLGTAMMLIGENSRVVAKAMADKLIQVQKSL 320
Cdd:PRK15127   238 TRLTsteefgkillkvNQDGSRVRLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFF 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  321 PAGVIVEPVYDRTNLVDKTIATVQKNLFEGAVLVIVILLLLLGNITGALITAMVIPLSML--FAITGMVGNRVSGNLMSL 398
Cdd:PRK15127   318 PSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLgtFAVLAAFGFSINTLTMFG 397
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  399 GAIDFGLIVDGAVIVVENCLRQlgMAQHKhgrlLTLSErlevVTSATKEVFSPAVFGI-LIIMLVYLPLFALSGVEGKMF 477
Cdd:PRK15127   398 MVLAIGLLVDDAIVVVENVERV--MAEEG----LPPKE----ATRKSMGQIQGALVGIaMVLSAVFVPMAFFGGSTGAIY 467
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  478 QPMAFTVVAALIGALIFAVTFVPAAIAVFVRGKVDESENAVMRGVKKIYKPLLNLS-----------LKLPWLMISIATV 546
Cdd:PRK15127   468 RQFSITIVSAMALSVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSthhytdsvgniLRSTGRYLVLYLI 547
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  547 LVLVLGFKVKNMGAEFLPQLDEGDIAMHALRITGTGIEQSVQMQKQLEQALLAQpEIANVFSKIGTADVASDPMPPNVAD 626
Cdd:PRK15127   548 IVVGMAYLFVRLPSSFLPDEDQGVFLTMVQLPAGATQERTQKVLNEVTDYYLTK-EKNNVESVFAVNGFGFAGRGQNTGI 626
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  627 TFLMLKPRAQWPDPSLSKDALVQRIRHRVNEVpgnnyefTQPIEMRFNeLIAGVRADVALriyGDDLAILKQFG---EKA 703
Cdd:PRK15127   627 AFVSLKDWADRPGEENKVEAITMRATRAFSQI-------KDAMVFAFN-LPAIVELGTAT---GFDFELIDQAGlghEKL 695
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  704 TSLMRNITGA--------TDVRLEQMEGLPTLSVTPMRDHMALLGLTVNDIQQTLAAAVGGVqtgliYEGDkrFSLLVRL 775
Cdd:PRK15127   696 TQARNQLLGEaakhpdmlVGVRPNGLEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGS-----YVND--FIDRGRV 768
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  776 DKRWSEDVSALARLPIALP----QSSNPELafVPLGEVATISIEKGPNQINRESGKRNVVVTANVA-GRDLAsfvrDAQA 850
Cdd:PRK15127   769 KKVYVMSEAKYRMLPDDIGdwyvRAADGQM--VPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAApGKSTG----EAME 842
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  851 TMNaQL--NLPSGYWLEYGGTFEQLQSASKRLSLVVPVTLLLIFGLLYSAFGSLRDSLIIFSGVPLALTGGVLALLLRDM 928
Cdd:PRK15127   843 LME-ELasKLPTGVGYDWTGMSYQERLSGNQAPALYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGL 921
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  929 PLSISAGVGFIALSGVAVLNGVVMLSFIKQLRN-EGLSLYYAIHSGALQRLRPVLMTALVASLGFIPMALNTGTGAEIQR 1007
Cdd:PRK15127   922 TNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDkEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQN 1001
                         1050      1060      1070
                   ....*....|....*....|....*....|....*
gi 1590405811 1008 PLATVVVGGIMSSTLLTLLILPALYKLVHGKFKKQ 1042
Cdd:PRK15127  1002 AVGTGVMGGMVTATVLAIFFVPVFFVVVRRRFSRK 1036
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
871-997 6.47e-08

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 56.79  E-value: 6.47e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  871 EQLQSASKRLSLVVPVTLLLIFGLLYSAFGSLRDSLIIF--SGVPLALTGGVLALLlrDMPLSISAGVGFIALSGVAVLN 948
Cdd:COG1033    211 DIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLlvVLLAVIWTLGLMGLL--GIPLSPLTILVPPLLLAIGIDY 288
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1590405811  949 GVVMLSFIKQLRNEGLSLYYAIHSGALQRLRPVLMTALVASLGFIPMAL 997
Cdd:COG1033    289 GIHLLNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLF 337
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
364-608 2.07e-05

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 48.70  E-value: 2.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  364 NITGALITAMVIPLSML--FAITGMVGNRVSGNLMSLGAIDFGLIVDGAVIVVeNCLRQLgMAQHKHgrlltlseRLEVV 441
Cdd:COG1033    241 SLRGVLLPLLVVLLAVIwtLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLL-NRYREE-RRKGLD--------KREAL 310
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  442 TSATKEVFSPAVFGILIIMLVYLplfALSGVEGKMFQPMAFTVVAALIGALIFAVTFVPAAIAVFVRGKVDESENAVMRG 521
Cdd:COG1033    311 REALRKLGPPVLLTSLTTAIGFL---SLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPKPKTRRLKKPPE 387
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  522 VKKIYKPLLNLSLKLPWLMISIATVLVLVLGFKVKNMG-----AEFLPQLDEGDIAMHAL--RITGT------------- 581
Cdd:COG1033    388 LGRLLAKLARFVLRRPKVILVVALVLAVVSLYGISRLKveydfEDYLPEDSPIRQDLDFIeeNFGGSdplevvvdtgepd 467
                          250       260
                   ....*....|....*....|....*....
gi 1590405811  582 GIEQSVQMQK--QLEQALLAQPEIANVFS 608
Cdd:COG1033    468 GLKDPEVLKEidRLQDYLESLPEVGKVLS 496
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
770-1026 5.66e-04

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 44.08  E-value: 5.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  770 SLLVRLDKRWSEDVSALARLPialpqsSNPELAFVPLGEVATISIEKGPNQINREsgKRNVVVTANVA---GRDLASFVR 846
Cdd:COG1033    499 DLVKELNQALNEGDPKYYALP------ESRELLAQLLLLLSSPPGDDLSRFVDED--YSAARVTVRLKdldSEEIKALVE 570
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  847 DAQATMNAQLNlPSGYWLEYGGTF----EQLQSASKRLSLVVPVTLLLIFGLLYSAFGSLRDSLI--IFSGVPLALTGGV 920
Cdd:COG1033    571 EVRAFLAENFP-PDGVEVTLTGSAvlfaAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLIslIPNLLPILLTFGL 649
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1590405811  921 LALLlrDMPLSIS-AGVGFIALsGVAVLNGVVMLSFIKQLRNEGLSLYYAIHSGALQRLRPVLMTALVASLGFIPMALnt 999
Cdd:COG1033    650 MGLL--GIPLNIAtAVVASIAL-GIGVDYTIHFLSRYREERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLF-- 724
                          250       260
                   ....*....|....*....|....*..
gi 1590405811 1000 gTGAEIQRPLATVVVGGIMSSTLLTLL 1026
Cdd:COG1033    725 -SSFPPLADFGLLLALGLLVALLAALL 750
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH