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Conserved domains on  [gi|1591565719|ref|WP_131810913|]
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sensor histidine kinase KdpD, partial [Mycolicibacterium monacense]

Protein Classification

sensor histidine kinase( domain architecture ID 11454343)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0007165|GO:0004673|GO:0000155
PubMed:  10637609|10339418
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
18-189 3.16e-48

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


:

Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 156.99  E-value: 3.16e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  18 LFEMSKINAGAVQPTFDRVALDEVVDDVLAAHRIAAERAGVQLRAELPDEPVRVLGSDRALVRVLSNLVANAIAHTPEGG 97
Cdd:COG2205    73 LLDLSRLESGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGG 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  98 RVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGSNDRVPRedsslpsGSGLGLAIAAGLVQAHRGTLSAHN-LD 176
Cdd:COG2205   153 TITISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEG-------GTGLGLAIVKRIVEAHGGTIWVESePG 225

                         170
                  ....*....|...
gi 1591565719 177 TGARFEVRLPLAS 189
Cdd:COG2205   226 GGTTFTVTLPLAE 238
 
Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
18-189 3.16e-48

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 156.99  E-value: 3.16e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  18 LFEMSKINAGAVQPTFDRVALDEVVDDVLAAHRIAAERAGVQLRAELPDEPVRVLGSDRALVRVLSNLVANAIAHTPEGG 97
Cdd:COG2205    73 LLDLSRLESGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGG 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  98 RVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGSNDRVPRedsslpsGSGLGLAIAAGLVQAHRGTLSAHN-LD 176
Cdd:COG2205   153 TITISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEG-------GTGLGLAIVKRIVEAHGGTIWVESePG 225

                         170
                  ....*....|...
gi 1591565719 177 TGARFEVRLPLAS 189
Cdd:COG2205   226 GGTTFTVTLPLAE 238
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 73-188 1.13e-29

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 105.42  E-value: 1.13e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719   73 GSDRALVRVLSNLVANAIAHTPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGSNdrvpreDSSLPSGS 152
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK------RSRKIGGT 74

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1591565719  153 GLGLAIAAGLVQAHRGTLSAHN-LDTGARFEVRLPLA 188
Cdd:smart00387  75 GLGLSIVKKLVELHGGEISVESePGGGTTFTITLPLE 111
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 78-185 9.43e-29

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 103.07  E-value: 9.43e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  78 LVRVLSNLVANAIAHTPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGSNDRVpredsslPSGSGLGLA 157
Cdd:cd00075     1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSRE-------GGGTGLGLA 73

                          90       100
                  ....*....|....*....|....*....
gi 1591565719 158 IAAGLVQAHRGTLSAHN-LDTGARFEVRL 185
Cdd:cd00075    74 IVRRIVEAHGGRITVESePGGGTTFTVTL 102
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 34-189 3.17e-25

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 101.07  E-value: 3.17e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  34 DRVALDEVVDDVLAAHRIAAERAGVQLRAELPDepVRVLGsDRALVR-VLSNLVANAIAHTPEGGRVQLALGSDENVAWA 112
Cdd:PRK11100  327 EPVALAALLEELVEAREAQAAAKGITLRLRPDD--ARVLG-DPFLLRqALGNLLDNAIDFSPEGGTITLSAEVDGEQVAL 403

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1591565719 113 RVDDTGVGIDEADLPRVFDVAYrgsndRVPREDSSlPSGSGLGLAIAAGLVQAHRGTLSAHNLD-TGARFEVRLPLAS 189
Cdd:PRK11100  404 SVEDQGPGIPDYALPRIFERFY-----SLPRPANG-RKSTGLGLAFVREVARLHGGEVTLRNRPeGGVLATLTLPRHF 475
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 73-188 3.11e-22

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 86.27  E-value: 3.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  73 GSDRALVRVLSNLVANAIAHTPEGGRVQLALGSDENVAWaRVDDTGVGIDEADLPRVFDVAYRGSNDRVpredsslpSGS 152
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGELTL-TVEDNGIGIPPEDLPRIFEPFSTADKRGG--------GGT 71

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1591565719 153 GLGLAIAAGLVQAHRGTLSAHN-LDTGARFEVRLPLA 188
Cdd:pfam02518  72 GLGLSIVRKLVELLGGTITVESePGGGTTVTLTLPLA 108
 
Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
18-189 3.16e-48

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 156.99  E-value: 3.16e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  18 LFEMSKINAGAVQPTFDRVALDEVVDDVLAAHRIAAERAGVQLRAELPDEPVRVLGSDRALVRVLSNLVANAIAHTPEGG 97
Cdd:COG2205    73 LLDLSRLESGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGG 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  98 RVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGSNDRVPRedsslpsGSGLGLAIAAGLVQAHRGTLSAHN-LD 176
Cdd:COG2205   153 TITISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEG-------GTGLGLAIVKRIVEAHGGTIWVESePG 225

                         170
                  ....*....|...
gi 1591565719 177 TGARFEVRLPLAS 189
Cdd:COG2205   226 GGTTFTVTLPLAE 238
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
18-190 2.52e-47

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 158.95  E-value: 2.52e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  18 LFEMSKINAGAVQPTFDRVALDEVVDDVLAAHRIAAERAGVQLRAELPDEPVRVLGSDRALVRVLSNLVANAIAHTPEGG 97
Cdd:COG5002   222 LLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGG 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  98 RVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGSNDRvpredSSLPSGSGLGLAIAAGLVQAHRGTLSAHN-LD 176
Cdd:COG5002   302 TITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSR-----SRETGGTGLGLAIVKHIVEAHGGRIWVESePG 376

                         170
                  ....*....|....
gi 1591565719 177 TGARFEVRLPLASD 190
Cdd:COG5002   377 KGTTFTITLPLARE 390
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
18-188 1.15e-44

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 150.44  E-value: 1.15e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  18 LFEMSKINAGAVQPTFDRVALDEVVDDVLAAHRIAAERAGVQLRAELPDEPVRVLGSDRALVRVLSNLVANAIAHTPEGG 97
Cdd:COG0642   164 LLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGG 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  98 RVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGSNDRvpredssLPSGSGLGLAIAAGLVQAHRGTLSAHN-LD 176
Cdd:COG0642   244 TVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSR-------RGGGTGLGLAIVKRIVELHGGTIEVESePG 316

                         170
                  ....*....|..
gi 1591565719 177 TGARFEVRLPLA 188
Cdd:COG0642   317 KGTTFTVTLPLA 328
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 30-190 3.23e-32

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 119.68  E-value: 3.23e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  30 QPTFDRVALDEVVDDVLAAHRIAAERAGVQLRAELPDEPVRVLGSDRALVRVLSNLVANAIAHTPEGGRVQLALGSDENV 109
Cdd:COG5000   270 EPQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGR 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719 110 AWARVDDTGVGIDEADLPRVFDVAYrgsndrvpredSSLPSGSGLGLAIAAGLVQAHRGTLSAHN-LDTGARFEVRLPLA 188
Cdd:COG5000   350 VRIEVSDNGPGIPEEVLERIFEPFF-----------TTKPKGTGLGLAIVKKIVEEHGGTIELESrPGGGTTFTIRLPLA 418


                  ..
gi 1591565719 189 SD 190
Cdd:COG5000   419 EE 420
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 73-188 1.13e-29

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 105.42  E-value: 1.13e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719   73 GSDRALVRVLSNLVANAIAHTPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGSNdrvpreDSSLPSGS 152
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK------RSRKIGGT 74

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1591565719  153 GLGLAIAAGLVQAHRGTLSAHN-LDTGARFEVRLPLA 188
Cdd:smart00387  75 GLGLSIVKKLVELHGGEISVESePGGGTTFTITLPLE 111
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 78-185 9.43e-29

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 103.07  E-value: 9.43e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  78 LVRVLSNLVANAIAHTPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGSNDRVpredsslPSGSGLGLA 157
Cdd:cd00075     1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSRE-------GGGTGLGLA 73

                          90       100
                  ....*....|....*....|....*....
gi 1591565719 158 IAAGLVQAHRGTLSAHN-LDTGARFEVRL 185
Cdd:cd00075    74 IVRRIVEAHGGRITVESePGGGTTFTVTL 102
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 30-188 4.19e-27

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 105.27  E-value: 4.19e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  30 QPTFDRVALDEVVDDVLAAHRIAAERAGVQLRAELPDEPVRVLGSDRALVRVLSNLVANAI--AHTPEGGRVQLALGSDE 107
Cdd:COG4191   209 EEEREPVDLNELIDEALELLRPRLKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIdaMEEGEGGRITISTRREG 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719 108 NVAWARVDDTGVGIDEADLPRVFDvayrgsndrvpredsslP--------SGSGLGLAIAAGLVQAHRGTLSAHN-LDTG 178
Cdd:COG4191   289 DYVVISVRDNGPGIPPEVLERIFE-----------------PffttkpvgKGTGLGLSISYGIVEKHGGRIEVESePGGG 351

                         170
                  ....*....|
gi 1591565719 179 ARFEVRLPLA 188
Cdd:COG4191   352 TTFTITLPLA 361
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 34-189 3.17e-25

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 101.07  E-value: 3.17e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  34 DRVALDEVVDDVLAAHRIAAERAGVQLRAELPDepVRVLGsDRALVR-VLSNLVANAIAHTPEGGRVQLALGSDENVAWA 112
Cdd:PRK11100  327 EPVALAALLEELVEAREAQAAAKGITLRLRPDD--ARVLG-DPFLLRqALGNLLDNAIDFSPEGGTITLSAEVDGEQVAL 403

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1591565719 113 RVDDTGVGIDEADLPRVFDVAYrgsndRVPREDSSlPSGSGLGLAIAAGLVQAHRGTLSAHNLD-TGARFEVRLPLAS 189
Cdd:PRK11100  404 SVEDQGPGIPDYALPRIFERFY-----SLPRPANG-RKSTGLGLAFVREVARLHGGEVTLRNRPeGGVLATLTLPRHF 475
envZ PRK09467
osmolarity sensor protein; Provisional
 30-188 2.76e-22

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 92.67  E-value: 2.76e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  30 QPTFDRVALDEVVDDVlaahrIAAERA-GVQLRAELPDEPVRVLGSDRALVRVLSNLVANAIAHTpeGGRVQLALGSDEN 108
Cdd:PRK09467  288 EMPMEMADLNALLGEV-----IAAESGyEREIETALQPGPIEVPMNPIAIKRALANLVVNAARYG--NGWIKVSSGTEGK 360

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719 109 VAWARVDDTGVGIDEADLPRVF------DVAyRGSndrvpredsslpSGSGLGLAIAAGLVQAHRGTLSAHN-LDTGARF 181
Cdd:PRK09467  361 RAWFQVEDDGPGIPPEQLKHLFqpftrgDSA-RGS------------SGTGLGLAIVKRIVDQHNGKVELGNsEEGGLSA 427


                  ....*..
gi 1591565719 182 EVRLPLA 188
Cdd:PRK09467  428 RAWLPLT 434
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 73-188 3.11e-22

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 86.27  E-value: 3.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  73 GSDRALVRVLSNLVANAIAHTPEGGRVQLALGSDENVAWaRVDDTGVGIDEADLPRVFDVAYRGSNDRVpredsslpSGS 152
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGELTL-TVEDNGIGIPPEDLPRIFEPFSTADKRGG--------GGT 71

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1591565719 153 GLGLAIAAGLVQAHRGTLSAHN-LDTGARFEVRLPLA 188
Cdd:pfam02518  72 GLGLSIVRKLVELLGGTITVESePGGGTTVTLTLPLA 108
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 81-187 1.69e-21

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 84.47  E-value: 1.69e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  81 VLSNLVANAIAHTPEGG---RVQLaLGSDENVAWAR--VDDTGVGIDEADLPRVFDVAYRGsndrvpreDSSL---PSGS 152
Cdd:cd16922     4 ILLNLLGNAIKFTEEGEvtlRVSL-EEEEEDGVQLRfsVEDTGIGIPEEQQARLFEPFSQA--------DSSTtrkYGGT 74

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1591565719 153 GLGLAIAAGLVQAHRGTLSAH-NLDTGARFEVRLPL 187
Cdd:cd16922    75 GLGLAISKKLVELMGGDISVEsEPGQGSTFTFTLPL 110
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
30-190 7.35e-21

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 87.98  E-value: 7.35e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  30 QPTFDRVALDEVVDDVLAahRIAAE-RAGVQLRAELPDEPVRVLGSDRALVRVLSNLVANAIAHTPEGGRVQLALGSDEN 108
Cdd:COG3852   198 PPEREPVNLHEVLERVLE--LLRAEaPKNIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQ 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719 109 VA--------WARVD--DTGVGIDEADLPRVFD--VayrgsndrvpredSSLPSGSGLGLAIAAGLVQAHRGTLSAHN-L 175
Cdd:COG3852   276 VTlgglrprlYVRIEviDNGPGIPEEILDRIFEpfF-------------TTKEKGTGLGLAIVQKIVEQHGGTIEVESeP 342

                         170
                  ....*....|....*
gi 1591565719 176 DTGARFEVRLPLASD 190
Cdd:COG3852   343 GKGTTFRIYLPLEQA 357
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 15-189 7.78e-21

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 89.07  E-value: 7.78e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  15 DGLLfEMSKInaGAVQPTFDRVALDEVVDDVLAAHRIAAERAGVQLR-AELPdepvRVLGSDRALVRVLSNLVANAIAHT 93
Cdd:COG4251   338 DDLL-AYSRV--GRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEvGPLP----TVRGDPTLLRQVFQNLISNAIKYS 410

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  94 PEGGRVQLALGSDENVAWAR--VDDTGVGIDEADLPRVFDVAYRGSNDRVPredsslpSGSGLGLAIAAGLVQAHRGTLS 171
Cdd:COG4251   411 RPGEPPRIEIGAEREGGEWVfsVRDNGIGIDPEYAEKIFEIFQRLHSRDEY-------EGTGIGLAIVKKIVERHGGRIW 483

                         170
                  ....*....|....*....
gi 1591565719 172 AH-NLDTGARFEVRLPLAS 189
Cdd:COG4251   484 VEsEPGEGATFYFTLPKAP 502
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 78-186 2.65e-19

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 78.58  E-value: 2.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  78 LVRVLSNLVANAIAHTPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGSNDRvpreDSslpSGSGLGLA 157
Cdd:cd16923     1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSR----NT---EGAGLGLS 73

                          90       100
                  ....*....|....*....|....*....
gi 1591565719 158 IAAGLVQAHRGTLSAHNLDTGARFEVRLP 186
Cdd:cd16923    74 IAKAIIELHGGSASAEYDDNHDLFKVRLP 102
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
11-186 4.19e-19

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 83.91  E-value: 4.19e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  11 LREADGL---LFEMSKINAGavqPTFDrvaLDEVVD-----DVLA--AHRIAAERAGVQLRAelpDEPVRVLGSDRALVR 80
Cdd:PRK11006  250 TQRMEGLvkqLLTLSKIEAA---PTID---LNEKVDvpmmlRVLEreAQTLSQGKHTITFEV---DNSLKVFGNEDQLRS 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  81 VLSNLVANAIAHTPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYrgsndRVPREDSSLPSGSGLGLAIAA 160
Cdd:PRK11006  321 AISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFY-----RVDKARSRQTGGSGLGLAIVK 395

                         170       180
                  ....*....|....*....|....*..
gi 1591565719 161 GLVQAHRGTLSAHN-LDTGARFEVRLP 186
Cdd:PRK11006  396 HALSHHDSRLEIESeVGKGTRFSFVLP 422
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
30-189 8.59e-18

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 80.40  E-value: 8.59e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  30 QPTFDRVALDEVVDDVLAAHRIAAERAGVQLRAELpDEPVRVLGSDRALV-RVLSNLVANAIAHTPEGGRVQLALG--SD 106
Cdd:PRK11360  453 ESQWQPVSLNALVEEVLQLFQTAGVQARVDFETEL-DNELPPIWADPELLkQVLLNILINAVQAISARGKIRIRTWqySD 531

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719 107 ENVAWArVDDTGVGIDEADLPRVFDVAYrgsndrvpredSSLPSGSGLGLAIAAGLVQAHRGTLSAHN-LDTGARFEVRL 185
Cdd:PRK11360  532 GQVAVS-IEDNGCGIDPELLKKIFDPFF-----------TTKAKGTGLGLALSQRIINAHGGDIEVESePGVGTTFTLYL 599


                  ....
gi 1591565719 186 PLAS 189
Cdd:PRK11360  600 PINP 603
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
34-186 2.96e-17

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 78.66  E-value: 2.96e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  34 DRVALD--EVVDDVLAAHRIAAERAGVQLRAElpDEPVRVLGSDRALVRVLSNLVANAIAHTPEGGRVQLALGSDENVAW 111
Cdd:PRK09835  332 EKKMLDlaDEVGKVFDFFEAWAEERGVELRFV--GDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQ 409

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1591565719 112 ARVDDTGVGIDEADLPRVFDVAYRGSNDRVPREDsslpsGSGLGLAIAAGLVQAHRGTLSAHNLDTGARFEVRLP 186
Cdd:PRK09835  410 LVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGE-----GSGIGLAIVKSIVVAHKGTVAVTSDARGTRFVISLP 479
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 78-187 3.71e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 73.23  E-value: 3.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  78 LVRVLSNLVANAIAHTPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYrgsndrvprEDSSLPSGSGLGLA 157
Cdd:cd16943     4 LNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF---------TTKPVGEGTGLGLS 74

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1591565719 158 IAAGLVQAHRGTLS-AHNLDTGARFEVRLPL 187
Cdd:cd16943    75 LSYRIIQKHGGTIRvASVPGGGTRFTIILPI 105
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 59-171 5.20e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 73.32  E-value: 5.20e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  59 QLRAELPDEPVRVLGSDRALVRVLSNLVANAIAHTPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGSN 138
Cdd:cd16947     2 QVEINIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLED 81

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1591565719 139 DRvpredSSLPSGSGLGLAIAAGLVQAHRGTLS 171
Cdd:cd16947    82 SR-----NSAKQGNGLGLTITKRLAESMGGSIY 109
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 78-187 6.66e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 72.36  E-value: 6.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  78 LVRVLSNLVANAIAHTPEggRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGSNDRvpredSSLPSGSGLGLA 157
Cdd:cd16949     1 LARALENVLRNALRYSPS--KILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSAR-----DRESGGTGLGLA 73

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1591565719 158 IAAGLVQAHRGTLSAHNLDT-GARFEVRLPL 187
Cdd:cd16949    74 IAERAIEQHGGKIKASNRKPgGLRVRIWLPA 104
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 45-190 2.93e-16

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 75.66  E-value: 2.93e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  45 VLAAHRIAAERaGVQLRAE----LPDEPVrvlgSDRALVRVLSNLVANAI----AHTPEGGRVQLALGSDENVAWARVDD 116
Cdd:COG3290   250 LLGKAARARER-GIDLTIDidsdLPDLPL----SDTDLVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDELVIEVED 324

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1591565719 117 TGVGIDEADLPRVFDvayrgsndrvpREDSS-LPSGSGLGLAIAAGLVQAHRGTLSAHNLD-TGARFEVRLPLASD 190
Cdd:COG3290   325 SGPGIPEELLEKIFE-----------RGFSTkLGEGRGLGLALVKQIVEKYGGTIEVESEEgEGTVFTVRLPKEGE 389
PRK10490 PRK10490
sensor protein KdpD; Provisional
 3-187 3.58e-16

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 75.84  E-value: 3.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719   3 IRDRVVDHLREADGLLfEMSKINAGAVQPTFDRVALDEVVDDVLaaHRIAAERAGVQLRAELPDEPVRVLGSDRALVRVL 82
Cdd:PRK10490  707 IRQQVLNTTRLVNNLL-DMARIQSGGFNLRKEWLTLEEVVGSAL--QMLEPGLSGHPINLSLPEPLTLIHVDGPLFERVL 783

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  83 SNLVANAIAHTpeGGRVQLALGSDENVAWARVD--DTGVGIDEADLPRVFDVAYRGsndrvpREDSSLPsGSGLGLAIAA 160
Cdd:PRK10490  784 INLLENAVKYA--GAQAEIGIDAHVEGERLQLDvwDNGPGIPPGQEQLIFDKFARG------NKESAIP-GVGLGLAICR 854

                         170       180
                  ....*....|....*....|....*...
gi 1591565719 161 GLVQAHRGTLSAHNLDT-GARFEVRLPL 187
Cdd:PRK10490  855 AIVEVHGGTIWAENRPEgGACFRVTLPL 882
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
21-192 5.95e-16

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 75.05  E-value: 5.95e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  21 MSKINAGAVQPTF-DRVALDEVVddvLAAHRIAAERAGVQLRAELPDEpVRVLGSDRALVRVLSNLVANAIAHTPEGGRV 99
Cdd:PRK10549  299 LSDEGALAYRKTPvDLVPLLEVA---GGAFRERFASRGLTLQLSLPDS-ATVFGDPDRLMQLFNNLLENSLRYTDSGGSL 374

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719 100 QLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYR--GSNDRVPredsslpSGSGLGLAIAAGLVQAHRGTLSA-HNLD 176
Cdd:PRK10549  375 HISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRteGSRNRAS-------GGSGLGLAICLNIVEAHNGRIIAaHSPF 447

                         170
                  ....*....|....*.
gi 1591565719 177 TGARFEVRLPLASDVS 192
Cdd:PRK10549  448 GGVSITVELPLERDLQ 463
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 76-186 6.14e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 70.18  E-value: 6.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  76 RALVRVLSNLVANAIAHTPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGSNDRvpredSSLPSGSGLG 155
Cdd:cd16946     3 DRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSR-----NRASGGSGLG 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1591565719 156 LAIAAGLVQAHRGTLSA-HNLDTGARFEVRLP 186
Cdd:cd16946    78 LAICHNIALAHGGTISAeHSPLGGLRLVLTLP 109
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 80-186 7.38e-16

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 69.83  E-value: 7.38e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  80 RVLSNLVANAIAHTPEGGRVQLALG-SDENVAWARVDDTGVGIDEADLPRVFDVAYRGSNDRvpredSSLPSGSGLGLAI 158
Cdd:cd16925     7 RVVLNLLSNAFKFTPDGGRIRCILEkFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSS-----TRAHGGTGLGLSI 81

                          90       100
                  ....*....|....*....|....*....
gi 1591565719 159 AAGLVQAHRGTLSAHNLDT-GARFEVRLP 186
Cdd:cd16925    82 VKEFVELHGGTVTVSDAPGgGALFQVELP 110
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 67-185 1.32e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 69.36  E-value: 1.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  67 EPVRVLGSDRALVRVLSNLVANAIAHTPEGGRVQLALgSDENVAWARVDDTGVGIDEADLPRVFdvayrgsnDRVPREDS 146
Cdd:cd16940     3 ADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKL-SADDGAVIRVEDNGPGIDEEELEALF--------ERFYRSDG 73

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1591565719 147 SLPSGSGLGLAIAAGLVQAHRGTLSAHNLDTGaRFEVRL 185
Cdd:cd16940    74 QNYGGSGLGLSIVKRIVELHGGQIFLGNAQGG-GLEAWV 111
PRK10604 PRK10604
sensor protein RstB; Provisional
 49-193 1.49e-15

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 73.87  E-value: 1.49e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  49 HRIAAERAGVQLRAELPDEPVRVLGSDRALVRVLSNLVANAIAHTpeGGRVQLALGSDENVAWARVDDTGVGIDEADLPR 128
Cdd:PRK10604  291 ADIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIVEDDGPGIPPEERER 368

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1591565719 129 VFD--VAYRGSNDRVpredsslPSGSGLGLAIAAGLVQAHRGTLSahnLDT----GARFEVRLPLASDVSD 193
Cdd:PRK10604  369 VFEpfVRLDPSRDRA-------TGGCGLGLAIVHSIALAMGGSVN---CDEselgGARFSFSWPVWHNLPQ 429
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 82-186 1.60e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 69.15  E-value: 1.60e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  82 LSNLVANAIAHTPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYrgsndRVPREDSSLPSGSGLGLAIAAG 161
Cdd:cd16952     5 FSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFY-----RVDIERCRNTGGTGLGLAIVKH 79

                          90       100
                  ....*....|....*....|....*.
gi 1591565719 162 LVQAHRGTLS-AHNLDTGARFEVRLP 186
Cdd:cd16952    80 VMSRHDARLLiASELGKGSRFTCLFP 105
PRK10337 PRK10337
sensor protein QseC; Provisional
 6-185 2.23e-15

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 73.14  E-value: 2.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719   6 RVVDHLreadgllFEMSKINAGAVQPTFDRVALDEVVDDVLAAHRIAAERAGVQLRAELPDEPVRVLGSDRALVRVLSNL 85
Cdd:PRK10337  288 RLVDQL-------LTLSRLDSLDNLQDVAEIPLEDLLQSAVMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNL 360

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  86 VANAIAHTPEGGRVQLALGSDEnvawARVDDTGVGIDEADLPRVFDVAYRGsndrvPREDSslpSGSGLGLAIAAGLVQA 165
Cdd:PRK10337  361 LDNAIRYSPQGSVVDVTLNARN----FTVRDNGPGVTPEALARIGERFYRP-----PGQEA---TGSGLGLSIVRRIAKL 428

                         170       180
                  ....*....|....*....|
gi 1591565719 166 HRGTLSAHNLDTGArFEVRL 185
Cdd:PRK10337  429 HGMNVSFGNAPEGG-FEAKV 447
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
38-187 2.00e-14

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 70.35  E-value: 2.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  38 LDEVVDDVLAAHRIAAERAGVQLRAELPDEPVRVLGSDRALVRVLSNLVANAIAHTPEggRVQLALGSDENVAWARVDDT 117
Cdd:PRK09470  314 ANSLWSEVLEDAKFEAEQMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSHT--KIEVAFSVDKDGLTITVDDD 391

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1591565719 118 GVGIDEADLPRVFDVAYRGSNDRvPREDSslpsGSGLGLAIAAGLVQAHRGTLSAHNLDTGA-RFEVRLPL 187
Cdd:PRK09470  392 GPGVPEEEREQIFRPFYRVDEAR-DRESG----GTGLGLAIVENAIQQHRGWVKAEDSPLGGlRLTIWLPL 457
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 78-159 2.82e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 65.77  E-value: 2.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  78 LVRVLSNLVANAIAHTPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGSNDRVPREdsslpsGSGLGLA 157
Cdd:cd16948     6 LSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQE------STGMGLY 79


                  ..
gi 1591565719 158 IA 159
Cdd:cd16948    80 LV 81
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 58-187 2.98e-14

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 70.32  E-value: 2.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  58 VQLRAELPDE-PVRVLGSDRALVRVLSNLVANAIAHTpEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRG 136
Cdd:PRK11466  541 IRLATDIADDlPTALMGDPRRIRQVITNLLSNALRFT-DEGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQV 619

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1591565719 137 SNDRvpredsslpSGSGLGLAIAAGLVQAHRGTLSAHN-LDTGARFEVRLPL 187
Cdd:PRK11466  620 SGKR---------GGTGLGLTISSRLAQAMGGELSATStPEVGSCFCLRLPL 662
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 78-186 6.45e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 64.90  E-value: 6.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  78 LVRVLSNLVANAIAHTP-EGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYrgsNDRVPREdsSLPSGSGLGL 156
Cdd:cd16953     1 LGQVLRNLIGNAISFSPpDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY---TERPANE--AFGQHSGLGL 75

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1591565719 157 AIAAGLVQAHRGTLSAHNLD-----TGARFEVRLP 186
Cdd:cd16953    76 SISRQIIEAHGGISVAENHNqpgqvIGARFTVQLP 110
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 20-187 8.82e-14

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 68.60  E-value: 8.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  20 EMSKIN---------AGAVQPTFDRVALDEVVDDVLAAHRIAAERAGVQLRAELPDEPVRVLGSDRALVRVLSNLVANAI 90
Cdd:COG5805   329 ELDRIEsiiseflalAKPQAVNKEKENINELIQDVVTLLETEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAI 408

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  91 AHTPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYrgsndrvpredSSLPSGSGLGLAIAAGLVQAHRGTL 170
Cdd:COG5805   409 EAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFF-----------TTKEKGTGLGLMVSYKIIENHNGTI 477

                         170
                  ....*....|....*...
gi 1591565719 171 S-AHNLDTGARFEVRLPL 187
Cdd:COG5805   478 DiDSKVGKGTTFTITLPL 495
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
35-192 1.00e-13

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 68.55  E-value: 1.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  35 RVALDEVVDDVLAAHRIAAERaGVQLRAELPDEPVRVLGSDRALVRVLSNLVANAIAHTPEGGRVQLALGSDENVAWA-- 112
Cdd:PRK13837  519 PFDLSELVTEIAPLLRVSLPP-GVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAKLRAPKvl 597

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719 113 -------------RVDDTGVGIDEADLPRVFDVAYrgsndrvpredSSLPSGSGLGLAIAAGLVQAHRGTLS-AHNLDTG 178
Cdd:PRK13837  598 shgvlppgryvllRVSDTGAGIDEAVLPHIFEPFF-----------TTRAGGTGLGLATVHGIVSAHAGYIDvQSTVGRG 666

                         170
                  ....*....|....
gi 1591565719 179 ARFEVRLPLASDVS 192
Cdd:PRK13837  667 TRFDVYLPPSSKVP 680
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 77-178 1.28e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 64.02  E-value: 1.28e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  77 ALVRVLSNLVANAIAHTPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGsndrvpreDSSLPSGS--GL 154
Cdd:cd16975     4 LLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRD--------DTSRRSGGhyGM 75

                          90       100
                  ....*....|....*....|....
gi 1591565719 155 GLAIAAGLVQAHRGTLSAHNLDTG 178
Cdd:cd16975    76 GLYIAKNLVEKHGGSLIIENSQKG 99
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 78-178 1.35e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 63.62  E-value: 1.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  78 LVRVLSNLVANAIAHTpeGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGSNDRVpredsslPSGSGLGLA 157
Cdd:cd16950     1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG-------TSGTGLGLA 71

                          90       100
                  ....*....|....*....|.
gi 1591565719 158 IAAGLVQAHRGTLSAHNLDTG 178
Cdd:cd16950    72 IVQRISDAHGGSLTLANRAGG 92
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
65-187 1.47e-13

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 68.08  E-value: 1.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  65 PDEPVRVLGSDRALVRVLSNLVANAIAHTPEGGRVqLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYR-GSNdrVPR 143
Cdd:PRK10841  550 PDVPVALNGDPMRLQQVISNLLSNAIKFTDTGCIV-LHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQvGTG--VQR 626

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1591565719 144 EdsslPSGSGLGLAIAAGLVQAHRGTLSAHN-LDTGARFEVRLPL 187
Cdd:PRK10841  627 N----FQGTGLGLAICEKLINMMDGDISVDSePGMGSQFTIRIPL 667
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 78-179 2.79e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 62.86  E-value: 2.79e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  78 LVRVLSNLVANAIAHTPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYrgsndRVPREDSSLPSgSGLGLA 157
Cdd:cd16945     5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFY-----SLPRPHSGQKS-TGLGLA 78

                          90       100
                  ....*....|....*....|..
gi 1591565719 158 IAAGLVQAHRGTLSAHNLDTGA 179
Cdd:cd16945    79 FVQEVAQLHGGRITLRNRPDGV 100
PRK15347 PRK15347
two component system sensor kinase;
18-187 7.71e-13

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 66.20  E-value: 7.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  18 LFEMSKINAGAVQPTFDRVALDEVVDDVLAAHRIAAERAGVQLRAELPDEPVRVLGSDRALVR-VLSNLVANAIAHTPEG 96
Cdd:PRK15347  453 LLDFSRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHVPLYLHLDSLRLRqILVNLLGNAVKFTETG 532

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  97 GrVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGSNDRvpredsslpSGSGLGLAIAAGLVQAHRGTLSAHN-L 175
Cdd:PRK15347  533 G-IRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHS---------QGTGLGLTIASSLAKMMGGELTLFStP 602

                         170
                  ....*....|..
gi 1591565719 176 DTGARFEVRLPL 187
Cdd:PRK15347  603 GVGSCFSLVLPL 614
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 21-190 8.12e-13

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 65.77  E-value: 8.12e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  21 MSKINAGAVQPtfdrVALDEVVDDVLAAHRIAAERAGVQLRAELPDEPVRVLGSDRALVRVLSNLVANAIAHTPEGGRVQ 100
Cdd:COG5809   327 LAKPQAIKYEP----KDLNTLIEEVIPLLQPQALLKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNIT 402

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719 101 LALGS-DENVAWARVDDTGVGIDEADLPRVFDVAYrgsndrvpredSSLPSGSGLGLAIAAGLVQAHRGTLSAHN-LDTG 178
Cdd:COG5809   403 IETKAeDDDKVVISVTDEGCGIPEERLKKLGEPFY-----------TTKEKGTGLGLMVSYKIIEEHGGKITVESeVGKG 471

                         170
                  ....*....|..
gi 1591565719 179 ARFEVRLPLASD 190
Cdd:COG5809   472 TTFSITLPIKLS 483
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
12-188 2.05e-12

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 64.81  E-value: 2.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  12 READGL------LFEMSKINAGAVQPtfdrVALDEVVDDVLAAHRIAAERAGVQLRAELPDE-PVRVLGSDRaLVRVLSN 84
Cdd:PRK10364  281 KEADRLnrvvseLLELVKPTHLALQA----VDLNDLINHSLQLVSQDANSREIQLRFTANDTlPEIQADPDR-LTQVLLN 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  85 LVANAIAHTPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGSNDrvpredsslpsGSGLGLAIAAGLVQ 164
Cdd:PRK10364  356 LYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAE-----------GTGLGLAVVHNIVE 424

                         170       180
                  ....*....|....*....|....*
gi 1591565719 165 AHRGTLSAHNLD-TGARFEVRLPLA 188
Cdd:PRK10364  425 QHGGTIQVASQEgKGATFTLWLPVN 449
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
42-193 2.22e-12

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 64.22  E-value: 2.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  42 VDDVLAAHR-----IAAERaGVQLRAELPDEPVRVLGsDRALVRV-LSNLVANAIAHTPEGGRVQLALGSDENVAWARVD 115
Cdd:PRK10755  208 LEDVILPSQdelseMLEQR-QQTLLLPESAADITVQG-DATLLRLlLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVE 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719 116 DTGVGIDEA---DLPRVFDvayrgsndrvpREDSSLpSGSGLGLAIAAGLVQAHRG--TLSAHNLDTGARFEVRLPLASD 190
Cdd:PRK10755  286 DEGPGIDESkcgELSKAFV-----------RMDSRY-GGIGLGLSIVSRITQLHHGqfFLQNRQERSGTRAWVWLPKAQN 353


                  ...
gi 1591565719 191 VSD 193
Cdd:PRK10755  354 VAN 356
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 55-185 6.03e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 57.64  E-value: 6.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  55 RAGVQLRAELPDEpVRVLGSDRALVRVLSNLVANAIAHTPEggRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDvay 134
Cdd:cd16954    16 RKGVSISLDISPE-LRFPGERNDLMELLGNLLDNACKWCLE--FVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQ--- 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1591565719 135 RGSndrvpREDSSLPsGSGLGLAIAAGLVQAHRGTLSA-HNLDTGARFEVRL 185
Cdd:cd16954    90 RGQ-----RLDEQRP-GQGLGLAIAKEIVEQYGGELSLsDSPLGGARFEVVF 135
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 81-186 7.73e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 56.64  E-value: 7.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  81 VLSNLVANAIAHTPEGG--RVQLALG---SDENVAWARVDDTGVGIDEADLPRVFDVAYrgsndrvpredSSLPSGSGLG 155
Cdd:cd16920     4 VLINLVRNGIEAMSEGGceRRELTIRtspADDRAVTISVKDTGPGIAEEVAGQLFDPFY-----------TTKSEGLGMG 72

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1591565719 156 LAIAAGLVQAHRGTLSA-HNLDTGARFEVRLP 186
Cdd:cd16920    73 LSICRSIIEAHGGRLSVeSPAGGGATFQFTLP 104
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 22-187 9.18e-11

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 59.86  E-value: 9.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  22 SKINAGAVQ----PtFD-RVALDEVVddVLAAHriAAERAGVQL----RAELPDEpvrVLGSDRALVRVLSNLVANAIAH 92
Cdd:PRK11107  352 SKLEAGKLVleniP-FSlRETLDEVV--TLLAH--SAHEKGLELtlniDPDVPDN---VIGDPLRLQQIITNLVGNAIKF 423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  93 TPEGG---RVQLALGSDENVAW-ARVDDTGVGIDEADLPRVFDvAYRgsndrvpREDSSLP---SGSGLGLAIAAGLVQA 165
Cdd:PRK11107  424 TESGNidiLVELRALSNTKVQLeVQIRDTGIGISERQQSQLFQ-AFR-------QADASISrrhGGTGLGLVITQKLVNE 495

                         170       180
                  ....*....|....*....|...
gi 1591565719 166 HRGTLSAHN-LDTGARFEVRLPL 187
Cdd:PRK11107  496 MGGDISFHSqPNRGSTFWFHLPL 518
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 78-186 3.87e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 54.64  E-value: 3.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  78 LVRVLSNLVANAIAHTPEGGRVQLALGSDENV-AWA-RVDDTGVGIDEADLPRVFDVAYRGSndrvPREDSSlpsGSGLG 155
Cdd:cd16921     1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVGeEWTfYVRDNGIGIDPEYAEKVFGIFQRLH----SREEYE---GTGVG 73

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1591565719 156 LAIAAGLVQAHRGTLSAHN-LDTGARFEVRLP 186
Cdd:cd16921    74 LAIVRKIIERHGGRIWLESePGEGTTFYFTLP 105
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 20-187 5.03e-10

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 58.03  E-value: 5.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  20 EMSKINAGAVQPTFDRVALDEVVDDVLAAHRIAAERAGVQLRAE-LPDEPVRVLGSDRALVRVLSNLVANAIAHTPEGGr 98
Cdd:PRK11091  340 DMDKMERRKLQLDNQPIDFTDFLADLENLSGLQAEQKGLRFDLEpLLPLPHKVITDGTRLRQILWNLISNAVKFTQQGG- 418

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  99 VQLALGSDEN-VAWARVDDTGVGIDEADLPRVFDVAYrgsndRVPREDSSLPS-GSGLGLAIAAGLVQAHRGTLSAHN-L 175
Cdd:PRK11091  419 VTVRVRYEEGdMLTFEVEDSGIGIPEDELDKIFAMYY-----QVKDSHGGKPAtGTGIGLAVSKRLAQAMGGDITVTSeE 493

                         170
                  ....*....|..
gi 1591565719 176 DTGARFEVRLPL 187
Cdd:PRK11091  494 GKGSCFTLTIHA 505
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 78-185 1.49e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 53.23  E-value: 1.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  78 LVRVLSNLVANAI--AHTPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYrgSNDRVPRedsslpsGSGLG 155
Cdd:cd16976     1 IQQVLMNLLQNALdaMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF--TTKPVGK-------GTGLG 71

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1591565719 156 LAIAAGLVQAHRGTLSAHNLDT-GARFEVRL 185
Cdd:cd16976    72 LSISYGIVEEHGGRLSVANEEGaGARFTFDL 102
PRK09303 PRK09303
histidine kinase;
75-168 6.17e-09

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 54.57  E-value: 6.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  75 DRALVR-VLSNLVANAIAHTPEGGRVQLAlGSDENVAWARVD--DTGVGIDEADLPRVFDVAYrgsndRVPREDSSlpSG 151
Cdd:PRK09303  269 DQERIRqVLLNLLDNAIKYTPEGGTITLS-MLHRTTQKVQVSicDTGPGIPEEEQERIFEDRV-----RLPRDEGT--EG 340

                          90
                  ....*....|....*..
gi 1591565719 152 SGLGLAIAAGLVQAHRG 168
Cdd:PRK09303  341 YGIGLSVCRRIVRVHYG 357
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 78-187 6.46e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 48.58  E-value: 6.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  78 LVRVLSNLVANAIAHTPEggRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGSNDRvpreDSSLPsGSGLGLA 157
Cdd:cd16939     1 MARALDNLLRNALRYAHR--TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSR----DRATG-GFGLGLA 73

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1591565719 158 IAAGLVQAHRGTLSAHNLDT-GARFEVRLPL 187
Cdd:cd16939    74 IVHRVALWHGGHVECDDSELgGACFRLTWPR 104
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 78-186 1.12e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 48.05  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  78 LVRVLSNLVANAI----AHTPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYrgsndrvpreDSSLPSGSG 153
Cdd:cd16915     1 LITIVGNLIDNALdalaATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGV----------STKGQGERG 70

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1591565719 154 LGLAIAAGLVQAHRGTLSAHNLDT-GARFEVRLP 186
Cdd:cd16915    71 IGLALVRQSVERLGGSITVESEPGgGTTFSIRIP 104
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 33-192 4.67e-07

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 49.13  E-value: 4.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  33 FDRVALDEVVDDVLAAHRIAAERAGVQLRAELPDepvRVLGSDRA--LVRVLSNLVANAI---AHTPEGGRVQLALGSDE 107
Cdd:COG3920   356 WEGVDLRDYLRELLEPLRDSYGGRGIRIELDGPD---VELPADAAvpLGLILNELVTNALkhaFLSGEGGRIRVSWRRED 432

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719 108 NVAWARVDDTGVGIDEadlprvfdvayrgsndrvpreDSSLPSGSGLGLAIAAGLVQAHRGTLSAHNlDTGARFEVRLPL 187
Cdd:COG3920   433 GRLRLTVSDNGVGLPE---------------------DVDPPARKGLGLRLIRALVRQLGGTLELDR-PEGTRVRITFPL 490


                  ....*
gi 1591565719 188 ASDVS 192
Cdd:COG3920   491 AELAA 495
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 78-186 3.60e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 43.93  E-value: 3.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  78 LVRVLSNLVANAI-AHTPEGGRV--------QLALGSDENVAWARVD--DTGVGIDEADLPRVFDVAYRGsndrvpREDs 146
Cdd:cd16918     1 LIQVFLNLVRNAAqALAGSGGEIilrtrtqrQVTLGHPRHRLALRVSviDNGPGIPPDLQDTIFYPMVSG------REN- 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1591565719 147 slpsGSGLGLAIAAGLVQAHRGTLSAHNLDTGARFEVRLP 186
Cdd:cd16918    74 ----GTGLGLAIAQNIVSQHGGVIECDSQPGHTVFSVSLP 109
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 78-186 1.28e-05

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 44.90  E-value: 1.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  78 LVRVLSNLVANAI--AHTPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYrgsndrvpredSSLPSGSGLG 155
Cdd:PRK11086  434 LITILGNLIENALeaVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY-----------STKGSNRGVG 502

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1591565719 156 LAIAAGLVQAHRGTLSAHNL-DTGARFEVRLP 186
Cdd:PRK11086  503 LYLVKQSVENLGGSIAVESEpGVGTQFFVQIP 534
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
16-187 1.96e-05

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 44.34  E-value: 1.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719   16 GLLFEMSKINAGAVQPTFDRVALDEVVDDVLAAH-RIAAERA-GVQLRAELPDEPVrVLGSDRALVRVLSNLVANAIAHT 93
Cdd:PRK09959   766 GEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFgAIAASKSiALSCSSTFPDHYL-VKIDPQAFKQVLSNLLSNALKFT 844

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719   94 PEGG-RVQLALGS-DENVAWARVD--DTGVGIDEADLPRVFDvayRGSNDRVPREDsslpSGSGLGLAIAAGLVQAHRGT 169
Cdd:PRK09959   845 TEGAvKITTSLGHiDDNHAVIKMTimDSGSGLSQEEQQQLFK---RYSQTSAGRQQ----TGSGLGLMICKELIKNMQGD 917

                          170
                   ....*....|....*....
gi 1591565719  170 LSAHNL-DTGARFEVRLPL 187
Cdd:PRK09959   918 LSLESHpGIGTTFTITIPV 936
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
80-187 1.23e-04

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 41.93  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  80 RVLSNLVANAIAH----TPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDvayrgsndrvprEDSSLPSGSGLG 155
Cdd:COG2972   339 LILQPLVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLE------------ELSSKGEGRGIG 406

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1591565719 156 LAIAAGLVQAHRG---TLS-AHNLDTGARFEVRLPL 187
Cdd:COG2972   407 LRNVRERLKLYYGeeyGLEiESEPGEGTTVTIRIPL 442
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
54-183 2.54e-04

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 40.77  E-value: 2.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  54 ERAGVQLRAELPDEpVRVLGSDRALVRVLSNLVANAIAHTPEggRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDva 133
Cdd:PRK10815  356 QRKGVNITLDISPE-ITFVGEKNDFMEVMGNVLDNACKYCLE--FVEISARQTDEHLHIVVEDDGPGIPESKRELIFD-- 430

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1591565719 134 yRGSndrvpREDSsLPSGSGLGLAIAAGLVQAHRGTLSAHN-LDTGARFEV 183
Cdd:PRK10815  431 -RGQ-----RADT-LRPGQGLGLSVAREITEQYEGKISAGDsPLGGARMEV 474
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
52-190 9.30e-04

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 38.83  E-value: 9.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  52 AAERAGVQLRAELPDEPVRVLGS-DRALVRVLSNLVANAIAHTPeGGRVQLALGSDENVAWARVDDTGVGIDEADLPrvf 130
Cdd:COG4585   136 LLRAAGIRVELDVDGDPDRLPPEvELALYRIVQEALTNALKHAG-ATRVTVTLEVDDGELTLTVRDDGVGFDPEAAP--- 211

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1591565719 131 dvayrgsndrvpredsslpsGSGLGLAIAAGLVQAHRGTLSAH-NLDTGARFEVRLPLASD 190
Cdd:COG4585   212 --------------------GGGLGLRGMRERAEALGGTLTIGsAPGGGTRVRATLPLAAA 252
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 81-186 1.67e-03

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 36.59  E-value: 1.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  81 VLSNLVANAIAHTPEGGRVQLALGS---DENVAWA------------RVDDTGVGIDEADLPRVFDVAYrgsndrvprED 145
Cdd:cd16919     4 AILNLAVNARDAMPEGGRLTIETSNqrvDADYALNyrdlipgnyvclEVSDTGSGMPAEVLRRAFEPFF---------TT 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1591565719 146 SSLPSGSGLGLAIAAGLVQAHRGTLSAHN-LDTGARFEVRLP 186
Cdd:cd16919    75 KEVGKGTGLGLSMVYGFVKQSGGHLRIYSePGVGTTVRIYLP 116
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
46-163 2.41e-03

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 36.43  E-value: 2.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591565719  46 LAAHRIAAERAGVQLRAELPDEPVRVLGSDRALVrVLSNLVANAIAHT---PEGGRVQLALGSDENVAWARVDDTGVGID 122
Cdd:COG2172     4 LPADLEDLGLARRAVRALLRELGLDEDDADDLVL-AVSEAVTNAVRHAyggDPDGPVEVELELDPDGLEIEVRDEGPGFD 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1591565719 123 EADLPrvfdvayrgsndrvprEDSSLPSGSGLGLAIAAGLV 163
Cdd:COG2172    83 PEDLP----------------DPYSTLAEGGRGLFLIRRLM 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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