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Conserved domains on  [gi|1593249952|ref|WP_132976018|]
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type IV pilus modification protein PilV [Thiobaca trueperi]

Protein Classification

PilV family protein( domain architecture ID 706969)

PilV family protein, similar to type IV pili (T4P) PilV protein; T4P, found on the surface of many Gram-negative and Gram-positive bacteria, facilitates biological functions important for bacterial pathogenicity, including twitching motility, DNA uptake, and adhesion to host cells

Gene Ontology:  GO:0044096
PubMed:  30988511|23204365

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
type_IV_pilV super family cl46944
type IV pilus modification protein PilV; Pilus systems categorized as type IV pilins differ ...
 15-134 2.97e-18

type IV pilus modification protein PilV; Pilus systems categorized as type IV pilins differ greatly from one another, with some showing greater similarty to type II or type III secretion systems than to each other. Members of this protein family represent the PilV protein of type IV pilus systems as found in Pseudomonas aeruginosa PAO1, Pseudomonas syringae DC3000, Neisseria meningitidis MC58, Xylella fastidiosa 9a5c, etc. [Cell envelope, Surface structures, Protein fate, Protein modification and repair]


The actual alignment was detected with superfamily member TIGR02523:

Pssm-ID: 131575  Cd Length: 139  Bit Score: 76.34  E-value: 2.97e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593249952  15 QRGFTLIEVLIAALVLSVGLLGLAGLQSVSLKLNQGSYLRTQATNLAYEITDAMRANRDKVAAYKGN-----------AE 83
Cdd:TIGR02523   1 QAGFSMIEVLVALLVLAIGVLGMAALQLKAVRYTRSASTRTIASMLAYNLLDRMRANPTALGDGNYNtytgyagtkasAV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1593249952  84 AEECEGDFTRTGSNIAEDDFNEWANRLACLLPEGQGNISASGN-------QITVTICW 134
Cdd:TIGR02523  81 AGDCATSSCTTANAAANADLKRWLSEVKNALPGGRGSICVDSNcdngangEVTVKIAW 138
 
Name Accession Description Interval E-value
type_IV_pilV TIGR02523
type IV pilus modification protein PilV; Pilus systems categorized as type IV pilins differ ...
 15-134 2.97e-18

type IV pilus modification protein PilV; Pilus systems categorized as type IV pilins differ greatly from one another, with some showing greater similarty to type II or type III secretion systems than to each other. Members of this protein family represent the PilV protein of type IV pilus systems as found in Pseudomonas aeruginosa PAO1, Pseudomonas syringae DC3000, Neisseria meningitidis MC58, Xylella fastidiosa 9a5c, etc. [Cell envelope, Surface structures, Protein fate, Protein modification and repair]


Pssm-ID: 131575  Cd Length: 139  Bit Score: 76.34  E-value: 2.97e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593249952  15 QRGFTLIEVLIAALVLSVGLLGLAGLQSVSLKLNQGSYLRTQATNLAYEITDAMRANRDKVAAYKGN-----------AE 83
Cdd:TIGR02523   1 QAGFSMIEVLVALLVLAIGVLGMAALQLKAVRYTRSASTRTIASMLAYNLLDRMRANPTALGDGNYNtytgyagtkasAV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1593249952  84 AEECEGDFTRTGSNIAEDDFNEWANRLACLLPEGQGNISASGN-------QITVTICW 134
Cdd:TIGR02523  81 AGDCATSSCTTANAAANADLKRWLSEVKNALPGGRGSICVDSNcdngangEVTVKIAW 138
PilV COG4967
Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];
14-78 8.73e-17

Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];


Pssm-ID: 443993 [Multi-domain]  Cd Length: 86  Bit Score: 70.78  E-value: 8.73e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1593249952  14 RQRGFTLIEVLIAALVLSVGLLGLAGLQSVSLKLNQGSYLRTQATNLAYEITDAMRANRDKVAAY 78
Cdd:COG4967     9 RQRGFTLIEVLVALVILSIGLLGLAGLQAASLRSSQDARQRTQAALLAQDLLERLRANPAAAGSY 73
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 14-26 2.35e-03

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 33.89  E-value: 2.35e-03
                          10
                  ....*....|...
gi 1593249952  14 RQRGFTLIEVLIA 26
Cdd:pfam07963   3 KQRGFTLIELLVA 15
 
Name Accession Description Interval E-value
type_IV_pilV TIGR02523
type IV pilus modification protein PilV; Pilus systems categorized as type IV pilins differ ...
 15-134 2.97e-18

type IV pilus modification protein PilV; Pilus systems categorized as type IV pilins differ greatly from one another, with some showing greater similarty to type II or type III secretion systems than to each other. Members of this protein family represent the PilV protein of type IV pilus systems as found in Pseudomonas aeruginosa PAO1, Pseudomonas syringae DC3000, Neisseria meningitidis MC58, Xylella fastidiosa 9a5c, etc. [Cell envelope, Surface structures, Protein fate, Protein modification and repair]


Pssm-ID: 131575  Cd Length: 139  Bit Score: 76.34  E-value: 2.97e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593249952  15 QRGFTLIEVLIAALVLSVGLLGLAGLQSVSLKLNQGSYLRTQATNLAYEITDAMRANRDKVAAYKGN-----------AE 83
Cdd:TIGR02523   1 QAGFSMIEVLVALLVLAIGVLGMAALQLKAVRYTRSASTRTIASMLAYNLLDRMRANPTALGDGNYNtytgyagtkasAV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1593249952  84 AEECEGDFTRTGSNIAEDDFNEWANRLACLLPEGQGNISASGN-------QITVTICW 134
Cdd:TIGR02523  81 AGDCATSSCTTANAAANADLKRWLSEVKNALPGGRGSICVDSNcdngangEVTVKIAW 138
PilV COG4967
Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];
14-78 8.73e-17

Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];


Pssm-ID: 443993 [Multi-domain]  Cd Length: 86  Bit Score: 70.78  E-value: 8.73e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1593249952  14 RQRGFTLIEVLIAALVLSVGLLGLAGLQSVSLKLNQGSYLRTQATNLAYEITDAMRANRDKVAAY 78
Cdd:COG4967     9 RQRGFTLIEVLVALVILSIGLLGLAGLQAASLRSSQDARQRTQAALLAQDLLERLRANPAAAGSY 73
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 14-26 2.35e-03

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 33.89  E-value: 2.35e-03
                          10
                  ....*....|...
gi 1593249952  14 RQRGFTLIEVLIA 26
Cdd:pfam07963   3 KQRGFTLIELLVA 15
PulJ COG4795
Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and ...
 14-26 5.02e-03

Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 443823 [Multi-domain]  Cd Length: 118  Bit Score: 34.99  E-value: 5.02e-03
                          10
                  ....*....|...
gi 1593249952  14 RQRGFTLIEVLIA 26
Cdd:COG4795     7 RQRGFTLLELLVA 19
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 14-26 5.09e-03

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 34.89  E-value: 5.09e-03
                          10
                  ....*....|...
gi 1593249952  14 RQRGFTLIEVLIA 26
Cdd:COG2165     9 RQRGFTLIELLVV 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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