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Conserved domains on  [gi|1593294886|ref|WP_133018433|]
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lipopolysaccharide assembly protein LapB [Streptococcus sp. KCJ4932]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11459274)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 55-141 3.98e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.33  E-value: 3.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593294886  55 RKRVDYYEELHEKGEISEKDYYFSKVNLGMLYKQNGLYQRALEQFEAVYELDSSDLFAcRHEIMALYILTSQYDKALVFF 134
Cdd:COG2956    55 RGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEA-LRLLAEIYEQEGDWEKAIEVL 133


                  ....*..
gi 1593294886 135 KKQSDIG 141
Cdd:COG2956   134 ERLLKLG 140
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 55-141 3.98e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.33  E-value: 3.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593294886  55 RKRVDYYEELHEKGEISEKDYYFSKVNLGMLYKQNGLYQRALEQFEAVYELDSSDLFAcRHEIMALYILTSQYDKALVFF 134
Cdd:COG2956    55 RGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEA-LRLLAEIYEQEGDWEKAIEVL 133


                  ....*..
gi 1593294886 135 KKQSDIG 141
Cdd:COG2956   134 ERLLKLG 140
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 55-141 3.98e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.33  E-value: 3.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593294886  55 RKRVDYYEELHEKGEISEKDYYFSKVNLGMLYKQNGLYQRALEQFEAVYELDSSDLFAcRHEIMALYILTSQYDKALVFF 134
Cdd:COG2956    55 RGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEA-LRLLAEIYEQEGDWEKAIEVL 133


                  ....*..
gi 1593294886 135 KKQSDIG 141
Cdd:COG2956   134 ERLLKLG 140
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 80-173 3.64e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.17  E-value: 3.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593294886  80 VNLGMLYKQNGLYQRALEQFEAVYELDSSDLFAcRHEIMALYILTSQYDKALVFFKKQSDIGHDILLEIPLL-VGAILDG 158
Cdd:COG2956   182 LLLAELYLEQGDYEEAIAALERALEQDPDYLPA-LPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALAdLLERKEG 260

                          90
                  ....*....|....*
gi 1593294886 159 HDEMAHYLIEVLNAD 173
Cdd:COG2956   261 LEAALALLERQLRRH 275
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
62-173 6.11e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 37.29  E-value: 6.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593294886  62 EELHEKGEISEKDYYFSKVNLGMLYKQNGLYQRALEQFEAVYELDSSDLFACRHEIMALYILtSQYDKALVFFKKQSDIG 141
Cdd:COG0457    96 LEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL-GRYEEALELLEKLEAAA 174

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1593294886 142 HDILLEIPLLVGAILDGHDEMAHYLIEVLNAD 173
Cdd:COG0457   175 LAALLAAALGEAALALAAAEVLLALLLALEQA 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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