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Conserved domains on  [gi|1695137503|ref|WP_140813987|]
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acetylxylan esterase [Streptococcus xiaochunlingii]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AXE1 super family cl38188
Acetyl xylan esterase (AXE1); This family consists of several bacterial acetyl xylan esterase ...
 2-317 1.22e-155

Acetyl xylan esterase (AXE1); This family consists of several bacterial acetyl xylan esterase proteins. Acetyl xylan esterases are enzymes that hydrolyse the ester linkages of the acetyl groups in position 2 and/or 3 of the xylose moieties of natural acetylated xylan from hardwood. These enzymes are one of the accessory enzymes which are part of the xylanolytic system, together with xylanases, beta-xylosidases, alpha-arabinofuranosidases and methylglucuronidases; these are all required for the complete hydrolysis of xylan.


The actual alignment was detected with superfamily member pfam05448:

Pssm-ID: 398876 [Multi-domain]  Cd Length: 316  Bit Score: 438.37  E-value: 1.22e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503   2 KNPAL-LEEMKTYKGRDEVPADFDDFWDKALANIAEL-PEYKLEEQNFSIPNVVCYELTFKGTRNGLVYARVVFPK-TDR 78
Cdd:pfam05448   1 ALFDLpLEELKTYRGRSPEPEDFDEFWDGELAELRKVdPDLELEPVDFHLPTVECYDLTFEGFGGARIYAWYVVPKeSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503  79 KVPVIFHFHGYMGRCWDWTDMLAYTVAGYGVVSMDVRGQSGYSTDGDRSPLGNTVKGQIIRGAVEgPDELFYKDVYLDLY 158
Cdd:pfam05448  81 KHPAVVHFHGYNGRRGDWHDMLHWAAHGYAVFVMDVRGQGGLSEDDPRGPKGNTYKGHITRGLLD-RETYYYRRVFLDAV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503 159 QLIEIVASLPQVDDSKLASYGASQGGALALVAAGLNPRIQRTVAIYPFLSDFRRVLEMGNTsEAYDELFRYFKFhDPFHE 238
Cdd:pfam05448 160 RAVEIVMSFPEVDEERIVVTGGSQGGALALAAAALSPRIKAVVADYPFLSDFRRAWEMDLE-HPYDELNRYFKR-DPHHE 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1695137503 239 TEDQIMETLAYIDVKNFAHRINGQVHMITGLDDNVCYPETQFAIYNRLECPKEHLIMPEYAHEAMNVQVNDRVYNWLCG 317
Cdd:pfam05448 238 REEEAFRTLSYFDIKNLAHRVKGPVLMAIGLIDDVCPPSTVFAAYNHLTTEKEIRVYPYFAHEYLGAFQNDKIYKFLSK 316
 
Name Accession Description Interval E-value
AXE1 pfam05448
Acetyl xylan esterase (AXE1); This family consists of several bacterial acetyl xylan esterase ...
 2-317 1.22e-155

Acetyl xylan esterase (AXE1); This family consists of several bacterial acetyl xylan esterase proteins. Acetyl xylan esterases are enzymes that hydrolyse the ester linkages of the acetyl groups in position 2 and/or 3 of the xylose moieties of natural acetylated xylan from hardwood. These enzymes are one of the accessory enzymes which are part of the xylanolytic system, together with xylanases, beta-xylosidases, alpha-arabinofuranosidases and methylglucuronidases; these are all required for the complete hydrolysis of xylan.


Pssm-ID: 398876 [Multi-domain]  Cd Length: 316  Bit Score: 438.37  E-value: 1.22e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503   2 KNPAL-LEEMKTYKGRDEVPADFDDFWDKALANIAEL-PEYKLEEQNFSIPNVVCYELTFKGTRNGLVYARVVFPK-TDR 78
Cdd:pfam05448   1 ALFDLpLEELKTYRGRSPEPEDFDEFWDGELAELRKVdPDLELEPVDFHLPTVECYDLTFEGFGGARIYAWYVVPKeSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503  79 KVPVIFHFHGYMGRCWDWTDMLAYTVAGYGVVSMDVRGQSGYSTDGDRSPLGNTVKGQIIRGAVEgPDELFYKDVYLDLY 158
Cdd:pfam05448  81 KHPAVVHFHGYNGRRGDWHDMLHWAAHGYAVFVMDVRGQGGLSEDDPRGPKGNTYKGHITRGLLD-RETYYYRRVFLDAV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503 159 QLIEIVASLPQVDDSKLASYGASQGGALALVAAGLNPRIQRTVAIYPFLSDFRRVLEMGNTsEAYDELFRYFKFhDPFHE 238
Cdd:pfam05448 160 RAVEIVMSFPEVDEERIVVTGGSQGGALALAAAALSPRIKAVVADYPFLSDFRRAWEMDLE-HPYDELNRYFKR-DPHHE 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1695137503 239 TEDQIMETLAYIDVKNFAHRINGQVHMITGLDDNVCYPETQFAIYNRLECPKEHLIMPEYAHEAMNVQVNDRVYNWLCG 317
Cdd:pfam05448 238 REEEAFRTLSYFDIKNLAHRVKGPVLMAIGLIDDVCPPSTVFAAYNHLTTEKEIRVYPYFAHEYLGAFQNDKIYKFLSK 316
Axe1 COG3458
Cephalosporin-C deacetylase or related acetyl esterase [Secondary metabolites biosynthesis, ...
 7-317 1.80e-123

Cephalosporin-C deacetylase or related acetyl esterase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442681 [Multi-domain]  Cd Length: 318  Bit Score: 356.81  E-value: 1.80e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503   7 LEEMKTYKGRDEVPADFDDFWDKALANIAELP-EYKLEEQNFSIPNVVCYELTFKGTRNGLVYARVVFPKTDRKVPVIFH 85
Cdd:COG3458     8 LEELRAYRPTLPEPADFDAFWDATLAEARAVPlDPELTPVETGLPGVEVYDVTFTGFGGARIYGWLLRPKGEGPLPAVVE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503  86 FHGYMGRCWDWTDMLAYTVAGYGVVSMDVRGQS---GYSTDGDRSPlGNTVKGQIIRGaVEGPDELFYKDVYLDLYQLIE 162
Cdd:COG3458    88 FHGYGGGRGLPHEDLDWAAAGYAVLVMDTRGQGsswGDTPDPGGYS-GGALPGYMTRG-IDDPDTYYYRRVYLDAVRAVD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503 163 IVASLPQVDDSKLASYGASQGGALALVAAGLNPRIQRTVAIYPFLSDFRRVLEMGnTSEAYDELFRYFKFHdpfHETEDQ 242
Cdd:COG3458   166 ALRSLPEVDGKRIGVTGGSQGGGLALAAAALDPRVKAAAADVPFLCDFRRALELG-RAGPYPEIRRYLRRH---REREPE 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1695137503 243 IMETLAYIDVKNFAHRINGQVHMITGLDDNVCYPETQFAIYNRLECPKEHLIMPEYAHEAMNVQVNDRVYNWLCG 317
Cdd:COG3458   242 VFETLSYFDAVNFARRIKAPVLFSVGLMDPVCPPSTVFAAYNALAGPKEILVYPFNGHEGGGPEQQDRQLAFLRE 316
/NonD TIGR00976
putative hydrolase, CocE/NonD family; This model represents a protein subfamily that includes ...
 62-202 3.14e-07

putative hydrolase, CocE/NonD family; This model represents a protein subfamily that includes the cocaine esterase CocE, several glutaryl-7-ACA acylases, and the putative diester hydrolase NonD of Streptomyces griseus (all hydrolases). This family shows extensive, low-level similarity to a family of xaa-pro dipeptidyl-peptidases, and local similarity by PSI-BLAST to many other hydrolases. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273375 [Multi-domain]  Cd Length: 550  Bit Score: 51.73  E-value: 3.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503  62 TRNGLVYARVVF-PKTDRKVPVIFHFHGY-----MGRCWDWTDMLAYTVAGYGVVSMDVRGqsgystdgdrsplgntvkg 135
Cdd:TIGR00976   3 MRDGTRLAIDVYrPAGGGPVPVILSRTPYgkdagLRWGLDKTEPAWFVAQGYAVVIQDTRG------------------- 63

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1695137503 136 qiiRGAVEGPDELFYKDVYLDLYQLIEIVASLPQVdDSKLASYGASQGGALALVAAGLNPRIQRTVA 202
Cdd:TIGR00976  64 ---RGASEGEFDLLGSDEAADGYDLVDWIAKQPWC-DGNVGMLGVSYLAVTQLLAAVLQPPALRAIA 126
 
Name Accession Description Interval E-value
AXE1 pfam05448
Acetyl xylan esterase (AXE1); This family consists of several bacterial acetyl xylan esterase ...
 2-317 1.22e-155

Acetyl xylan esterase (AXE1); This family consists of several bacterial acetyl xylan esterase proteins. Acetyl xylan esterases are enzymes that hydrolyse the ester linkages of the acetyl groups in position 2 and/or 3 of the xylose moieties of natural acetylated xylan from hardwood. These enzymes are one of the accessory enzymes which are part of the xylanolytic system, together with xylanases, beta-xylosidases, alpha-arabinofuranosidases and methylglucuronidases; these are all required for the complete hydrolysis of xylan.


Pssm-ID: 398876 [Multi-domain]  Cd Length: 316  Bit Score: 438.37  E-value: 1.22e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503   2 KNPAL-LEEMKTYKGRDEVPADFDDFWDKALANIAEL-PEYKLEEQNFSIPNVVCYELTFKGTRNGLVYARVVFPK-TDR 78
Cdd:pfam05448   1 ALFDLpLEELKTYRGRSPEPEDFDEFWDGELAELRKVdPDLELEPVDFHLPTVECYDLTFEGFGGARIYAWYVVPKeSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503  79 KVPVIFHFHGYMGRCWDWTDMLAYTVAGYGVVSMDVRGQSGYSTDGDRSPLGNTVKGQIIRGAVEgPDELFYKDVYLDLY 158
Cdd:pfam05448  81 KHPAVVHFHGYNGRRGDWHDMLHWAAHGYAVFVMDVRGQGGLSEDDPRGPKGNTYKGHITRGLLD-RETYYYRRVFLDAV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503 159 QLIEIVASLPQVDDSKLASYGASQGGALALVAAGLNPRIQRTVAIYPFLSDFRRVLEMGNTsEAYDELFRYFKFhDPFHE 238
Cdd:pfam05448 160 RAVEIVMSFPEVDEERIVVTGGSQGGALALAAAALSPRIKAVVADYPFLSDFRRAWEMDLE-HPYDELNRYFKR-DPHHE 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1695137503 239 TEDQIMETLAYIDVKNFAHRINGQVHMITGLDDNVCYPETQFAIYNRLECPKEHLIMPEYAHEAMNVQVNDRVYNWLCG 317
Cdd:pfam05448 238 REEEAFRTLSYFDIKNLAHRVKGPVLMAIGLIDDVCPPSTVFAAYNHLTTEKEIRVYPYFAHEYLGAFQNDKIYKFLSK 316
Axe1 COG3458
Cephalosporin-C deacetylase or related acetyl esterase [Secondary metabolites biosynthesis, ...
 7-317 1.80e-123

Cephalosporin-C deacetylase or related acetyl esterase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442681 [Multi-domain]  Cd Length: 318  Bit Score: 356.81  E-value: 1.80e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503   7 LEEMKTYKGRDEVPADFDDFWDKALANIAELP-EYKLEEQNFSIPNVVCYELTFKGTRNGLVYARVVFPKTDRKVPVIFH 85
Cdd:COG3458     8 LEELRAYRPTLPEPADFDAFWDATLAEARAVPlDPELTPVETGLPGVEVYDVTFTGFGGARIYGWLLRPKGEGPLPAVVE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503  86 FHGYMGRCWDWTDMLAYTVAGYGVVSMDVRGQS---GYSTDGDRSPlGNTVKGQIIRGaVEGPDELFYKDVYLDLYQLIE 162
Cdd:COG3458    88 FHGYGGGRGLPHEDLDWAAAGYAVLVMDTRGQGsswGDTPDPGGYS-GGALPGYMTRG-IDDPDTYYYRRVYLDAVRAVD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503 163 IVASLPQVDDSKLASYGASQGGALALVAAGLNPRIQRTVAIYPFLSDFRRVLEMGnTSEAYDELFRYFKFHdpfHETEDQ 242
Cdd:COG3458   166 ALRSLPEVDGKRIGVTGGSQGGGLALAAAALDPRVKAAAADVPFLCDFRRALELG-RAGPYPEIRRYLRRH---REREPE 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1695137503 243 IMETLAYIDVKNFAHRINGQVHMITGLDDNVCYPETQFAIYNRLECPKEHLIMPEYAHEAMNVQVNDRVYNWLCG 317
Cdd:COG3458   242 VFETLSYFDAVNFARRIKAPVLFSVGLMDPVCPPSTVFAAYNALAGPKEILVYPFNGHEGGGPEQQDRQLAFLRE 316
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
58-315 4.78e-22

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 92.77  E-value: 4.78e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503  58 TFKGTRNGLVYARVVFPKTDRKVPVIFHFHGYMGRCWDWTDMLAYTVA--GYGVVSMDVRGqsgystdgdrsplgntvkg 135
Cdd:COG1506     1 TFKSADGTTLPGWLYLPADGKKYPVVVYVHGGPGSRDDSFLPLAQALAsrGYAVLAPDYRG------------------- 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503 136 qiiRGAVEGPdelFYKDVYLDLYQLIEIVASLPQVDDSKLASYGASQGGALALVAAGLNP-RIQRTVAIYPFlSDFRRVL 214
Cdd:COG1506    62 ---YGESAGD---WGGDEVDDVLAAIDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPdRFKAAVALAGV-SDLRSYY 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503 215 EmgnTSEAYDELFRyfkfhdpfhETEDQIMETLAYIDVKNFAHRINGQVHMITGLDDNVCYPETQFAIYNRLEC---PKE 291
Cdd:COG1506   135 G---TTREYTERLM---------GGPWEDPEAYAARSPLAYADKLKTPLLLIHGEADDRVPPEQAERLYEALKKagkPVE 202

                         250       260
                  ....*....|....*....|....*..
gi 1695137503 292 HLIMPEYAHE---AMNVQVNDRVYNWL 315
Cdd:COG1506   203 LLVYPGEGHGfsgAGAPDYLERILDFL 229
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
56-207 4.65e-14

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 70.38  E-value: 4.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503  56 ELTFKGTRNGLVYARVVFPKTDRKVPVIFHFHGYMG---RCWDWTDMLAytVAGYGVVSMDVRGQSGYSTDGDRsplGNT 132
Cdd:COG0412     5 TVTIPTPDGVTLPGYLARPAGGGPRPGVVVLHEIFGlnpHIRDVARRLA--AAGYVVLAPDLYGRGGPGDDPDE---ARA 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1695137503 133 VKGQIIRGAVEGpdelfykdvylDLYQLIEIVASLPQVDDSKLASYGASQGGALALVAAGLNPRIQRTVAIYPFL 207
Cdd:COG0412    80 LMGALDPELLAA-----------DLRAALDWLKAQPEVDAGRVGVVGFCFGGGLALLAAARGPDLAAAVSFYGGL 143
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
56-315 8.48e-13

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 66.56  E-value: 8.48e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503  56 ELTFKGTRNGLVYARVVFPKTDRKVPVIFhFHGYMGRCWDWTDMLAY-TVAGYGVVSMDVRGQsGYSTDGdrsplgntvk 134
Cdd:COG2267     5 LVTLPTRDGLRLRGRRWRPAGSPRGTVVL-VHGLGEHSGRYAELAEAlAAAGYAVLAFDLRGH-GRSDGP---------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503 135 gqiiRGAVEGpdelfYKDVYLDLYQLIEIVASLPqvdDSKLASYGASQGGALALVAAGLNP-RIQRTVAIYPFLsdfrrv 213
Cdd:COG2267    73 ----RGHVDS-----FDDYVDDLRAALDALRARP---GLPVVLLGHSMGGLIALLYAARYPdRVAGLVLLAPAY------ 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503 214 lemgntseaydelfryfkFHDPFHETEDQIMETLAyidVKNFAHRINGQVHMITGLDDNVCYPETQFAIYNRLECPKEHL 293
Cdd:COG2267   135 ------------------RADPLLGPSARWLRALR---LAEALARIDVPVLVLHGGADRVVPPEAARRLAARLSPDVELV 193

                         250       260
                  ....*....|....*....|....*.
gi 1695137503 294 IMPEYAHEAMN----VQVNDRVYNWL 315
Cdd:COG2267   194 LLPGARHELLNeparEEVLAAILAWL 219
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 56-300 8.55e-12

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 64.17  E-value: 8.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503  56 ELTFKgTRNGL-VYARVVFPKT-DRKVPVIFHFHGYMGrCWDWTDMLAYTVA--GYGVVSMDVRGQsgystdgdrsplgn 131
Cdd:COG1073    12 DVTFK-SRDGIkLAGDLYLPAGaSKKYPAVVVAHGNGG-VKEQRALYAQRLAelGFNVLAFDYRGY-------------- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503 132 tvkgqiirGAVEG-PDELFYKDVYlDLYQLIEIVASLPQVDDSKLASYGASQGGALALVAAGLNPRIQRTVAIYPFlSDF 210
Cdd:COG1073    76 --------GESEGePREEGSPERR-DARAAVDYLRTLPGVDPERIGLLGISLGGGYALNAAATDPRVKAVILDSPF-TSL 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503 211 RRVLEMGnTSEAYDELFRYFKFHDPFheTEDQIMETLAyiDVKNFAHRINGQVHMITGLDDNVCYPETQFAIYNRLECPK 290
Cdd:COG1073   146 EDLAAQR-AKEARGAYLPGVPYLPNV--RLASLLNDEF--DPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEPK 220

                         250
                  ....*....|
gi 1695137503 291 EHLIMPEYAH 300
Cdd:COG1073   221 ELLIVPGAGH 230
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 81-315 1.62e-09

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 56.93  E-value: 1.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503  81 PVIFhFHGYMGRCWDWTDMLAYTVAGYGVVSMDVRGQsGYStdgDRSPLGNTVKGQIirgavegpdelfykdvyLDLYQL 160
Cdd:COG0596    25 PVVL-LHGLPGSSYEWRPLIPALAAGYRVIAPDLRGH-GRS---DKPAGGYTLDDLA-----------------DDLAAL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503 161 IEivaslpQVDDSKLASYGASQGGALALVAAGLNP-RIQRTVAIypflsdfrrvlemgntSEAYDELFRYFKFHDPFHET 239
Cdd:COG0596    83 LD------ALGLERVVLVGHSMGGMVALELAARHPeRVAGLVLV----------------DEVLAALAEPLRRPGLAPEA 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503 240 EDQIMETLAYIDVKNFAHRINGQVHMITGLDDNVCYPETQFAIYNRLecPK-EHLIMPE---YAHEAMNVQVNDRVYNWL 315
Cdd:COG0596   141 LAALLRALARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELL--PNaELVVLPGaghFPPLEQPEAFAAALRDFL 218
/NonD TIGR00976
putative hydrolase, CocE/NonD family; This model represents a protein subfamily that includes ...
 62-202 3.14e-07

putative hydrolase, CocE/NonD family; This model represents a protein subfamily that includes the cocaine esterase CocE, several glutaryl-7-ACA acylases, and the putative diester hydrolase NonD of Streptomyces griseus (all hydrolases). This family shows extensive, low-level similarity to a family of xaa-pro dipeptidyl-peptidases, and local similarity by PSI-BLAST to many other hydrolases. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273375 [Multi-domain]  Cd Length: 550  Bit Score: 51.73  E-value: 3.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503  62 TRNGLVYARVVF-PKTDRKVPVIFHFHGY-----MGRCWDWTDMLAYTVAGYGVVSMDVRGqsgystdgdrsplgntvkg 135
Cdd:TIGR00976   3 MRDGTRLAIDVYrPAGGGPVPVILSRTPYgkdagLRWGLDKTEPAWFVAQGYAVVIQDTRG------------------- 63

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1695137503 136 qiiRGAVEGPDELFYKDVYLDLYQLIEIVASLPQVdDSKLASYGASQGGALALVAAGLNPRIQRTVA 202
Cdd:TIGR00976  64 ---RGASEGEFDLLGSDEAADGYDLVDWIAKQPWC-DGNVGMLGVSYLAVTQLLAAVLQPPALRAIA 126
Peptidase_S15 pfam02129
X-Pro dipeptidyl-peptidase (S15 family);
60-203 9.76e-07

X-Pro dipeptidyl-peptidase (S15 family);


Pssm-ID: 396621 [Multi-domain]  Cd Length: 264  Bit Score: 49.26  E-value: 9.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503  60 KGTRnglVYARVVFP-KTDRKVPVIFH---FHGYMGRCWDWTDMLAYTV---AGYGVVSMDVRGQsgYSTDGDRSPlgnt 132
Cdd:pfam02129   1 DGVR---LAADIYRPtKTGGPVPALLTrspYGARRDGASDLALAHPEWEfaaRGYAVVYQDVRGT--GGSEGVFTV---- 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1695137503 133 vkgqiirgavEGPDELfykdvyLDLYQLIEIVASLPQvDDSKLASYGASQGGALALVAAGLNPRIQRTVAI 203
Cdd:pfam02129  72 ----------GGPQEA------ADGKDVIDWLAGQPW-CNGKVGMTGISYLGTTQLAAAATGPPGLKAIAP 125
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
105-278 7.86e-06

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 46.07  E-value: 7.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503 105 AGYGVVSMDVRGQSGYSTDgdrspLGNTVKGQiirgavegpdelfYKDVylDLYQLIEIV---ASLPQVDDSKLASYGAS 181
Cdd:pfam00326  13 RGYVVAIANGRGSGGYGEA-----FHDAGKGD-------------LGQN--EFDDFIAAAeylIEQGYTDPDRLAIWGGS 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503 182 QGGALALVAAGLNPRIQRT-VAIYPFlSDFRRVleMGNTSEAYDElfRYFKFHDPFHETEDQiMETLAYIDVKNFahRIN 260
Cdd:pfam00326  73 YGGYLTGAALNQRPDLFKAaVAHVPV-VDWLAY--MSDTSLPFTE--RYMEWGNPWDNEEGY-DYLSPYSPADNV--KVY 144

                         170
                  ....*....|....*....
gi 1695137503 261 GQVHMITGL-DDNVCYPET 278
Cdd:pfam00326 145 PPLLLIHGLlDDRVPPWQS 163
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
179-315 4.10e-05

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 44.16  E-value: 4.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503 179 GASQGGALALVAAGLNPRIQRTV----AIY---------PFLSDFRRVLEMGNTSEAYDELFRYFKFHDPFHETEdQIME 245
Cdd:COG1647    90 GLSMGGLLALLLAARYPDVAGLVllspALKiddpsapllPLLKYLARSLRGIGSDIEDPEVAEYAYDRTPLRALA-ELQR 168

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1695137503 246 TLAYidVKNFAHRINGQVHMITGLDDNVCYPETQFAIYNRLECPK---------EHLIMPEYAHEamnvQVNDRVYNWL 315
Cdd:COG1647   169 LIRE--VRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDkelvwledsGHVITLDKDRE----EVAEEILDFL 241
COG2936 COG2936
Predicted acyl esterase [General function prediction only];
61-195 5.44e-05

Predicted acyl esterase [General function prediction only];


Pssm-ID: 442179 [Multi-domain]  Cd Length: 555  Bit Score: 44.53  E-value: 5.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503  61 GTRnglVYARVVFPK-TDRKVPVIFHFHGYmgRCWDWTDMLAYTVA------GYGVVSMDVRGqSGYStDGDRSPLgntv 133
Cdd:COG2936    22 GVR---LAADIYRPKdAEGPVPVILERTPY--GKRDGTAGRDLGPHpyfaerGYAVVVQDVRG-TGGS-EGEFDPY---- 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1695137503 134 kgqiirgaveGPDELfykdvyLDLYQLIEIVASLPQVDDsKLASYGASQGGALALVAAGLNP 195
Cdd:COG2936    91 ----------RVDEQ------TDGYDTIDWLAKQPWSNG-KVGMIGISYGGFTQLAAAADRP 135
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 78-196 2.91e-04

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 41.43  E-value: 2.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503  78 RKVPVIFH-FHGYMGR----CWDWTDmlaytvAGYGVVSMDVRGQsGYStDGdrsplgntvkgqiIRGAVEGPDelfykD 152
Cdd:pfam12146   4 RAVVVLVHgLGEHSGRyahlADALAA------QGFAVYAYDHRGH-GRS-DG-------------KRGHVPSFD-----D 57

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1695137503 153 VYLDLYQLIEIVASlpQVDDSKLASYGASQGGALALVAAGLNPR 196
Cdd:pfam12146  58 YVDDLDTFVDKIRE--EHPGLPLFLLGHSMGGLIAALYALRYPD 99
DLH pfam01738
Dienelactone hydrolase family;
156-205 3.73e-04

Dienelactone hydrolase family;


Pssm-ID: 396343 [Multi-domain]  Cd Length: 213  Bit Score: 41.18  E-value: 3.73e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1695137503 156 DLYQLIEIVASLPQVDDSKLASYGASQGGALALVAAGLNPRIQRTVAIYP 205
Cdd:pfam01738  79 DLEAAVNYLKSQPEVSPKKVGVVGYCMGGALAVLLAAKGPLVDAAVGFYG 128
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
52-199 8.66e-03

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 37.39  E-value: 8.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503  52 VVCYELTFK-GTRNGLVYARVVFPKT-------DRKVPVIFHFHGYMGrcwDWTDM--LAYTVAGYG--VVSMDVRGqsg 119
Cdd:COG4188    26 VGVQTLTLRdPSRDRPLPVDVWYPATapadapaGGPFPLVVLSHGLGG---SREGYayLAEHLASHGyvVAAPDHPG--- 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695137503 120 ySTDGDRSPLGNtvkgqiirGAVEGPDELFYKDVYLD----LYQLIEIVASLP----QVDDSKLASYGASQGGALALVAA 191
Cdd:COG4188   100 -SNAADLSAALD--------GLADALDPEELWERPLDlsfvLDQLLALNKSDPplagRLDLDRIGVIGHSLGGYTALALA 170


                  ....*...
gi 1695137503 192 GLNPRIQR 199
Cdd:COG4188   171 GARLDFAA 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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