type II secretion system (T2SS) F family protein similar to Pseudomonas type IV fimbrial assembly protein PilC and Xanthomonas campestris T2SS F, which is involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
competence type IV pilus assembly protein ComGB; Members of this family occur in Gram-positive ...
11-343
3.83e-115
competence type IV pilus assembly protein ComGB; Members of this family occur in Gram-positive bacteria as part of a type IV pilus system used for DNA binding and uptake when species such as Streptococcus pneumoniae or Bacilus subtilis are in a competent state for natural transformation. Members of this family, typically called ComGB (second protein of the ComG operon), belong more broadly to the family of GspF, part of type 2 secretion systems (T2SS) in Gram-negative bacteria.
The actual alignment was detected with superfamily member NF041012:
Pssm-ID: 468941 [Multi-domain] Cd Length: 333 Bit Score: 336.75 E-value: 3.83e-115
competence type IV pilus assembly protein ComGB; Members of this family occur in Gram-positive ...
11-343
3.83e-115
competence type IV pilus assembly protein ComGB; Members of this family occur in Gram-positive bacteria as part of a type IV pilus system used for DNA binding and uptake when species such as Streptococcus pneumoniae or Bacilus subtilis are in a competent state for natural transformation. Members of this family, typically called ComGB (second protein of the ComG operon), belong more broadly to the family of GspF, part of type 2 secretion systems (T2SS) in Gram-negative bacteria.
Pssm-ID: 468941 [Multi-domain] Cd Length: 333 Bit Score: 336.75 E-value: 3.83e-115
type II secretion system protein F; This membrane protein is a component of the terminal ...
9-345
4.86e-18
type II secretion system protein F; This membrane protein is a component of the terminal branch complex of the general secretion pathway (GSP), also known as the"Type II" secretion pathway. The GSP transports proteins (generally virulence-associated cell wall hydrolases) across the outer membrase of the bacterial cell. Transport across the inner membrane is often, but not exclusively handled by the Sec system. This model was constructed from the broader subfamily model, pfam00482 which includes components of pilin complexes (PilC) as well as other related genes. GspF is nearly always gene clustered with other GSP subunits. Some genes from Xylella and Xanthomonas strains score below the trusted cutoff due to excessive divergence from the family such that a sequence from Deinococcus which does not appear to be GspF scores higher. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 273980 [Multi-domain] Cd Length: 399 Bit Score: 84.30 E-value: 4.86e-18
Type II secretion system (T2SS), protein F; The original family covered both the regions found ...
224-331
1.83e-09
Type II secretion system (T2SS), protein F; The original family covered both the regions found by the current model. The splitting of the family has allowed the related FlaJ_arch (archaeal FlaJ family) to be merged with it. Proteins with this domain in form a platform for the machiney of the Type II secretion system, as well as the Type 4 pili and the archaeal flagella. This domain seems to show some similarity to PF00664 but this may just be due to similarities in the TM helices (personal obs: C Yeats).
Pssm-ID: 425708 [Multi-domain] Cd Length: 119 Bit Score: 55.03 E-value: 1.83e-09
competence type IV pilus assembly protein ComGB; Members of this family occur in Gram-positive ...
11-343
3.83e-115
competence type IV pilus assembly protein ComGB; Members of this family occur in Gram-positive bacteria as part of a type IV pilus system used for DNA binding and uptake when species such as Streptococcus pneumoniae or Bacilus subtilis are in a competent state for natural transformation. Members of this family, typically called ComGB (second protein of the ComG operon), belong more broadly to the family of GspF, part of type 2 secretion systems (T2SS) in Gram-negative bacteria.
Pssm-ID: 468941 [Multi-domain] Cd Length: 333 Bit Score: 336.75 E-value: 3.83e-115
type II secretion system protein F; This membrane protein is a component of the terminal ...
9-345
4.86e-18
type II secretion system protein F; This membrane protein is a component of the terminal branch complex of the general secretion pathway (GSP), also known as the"Type II" secretion pathway. The GSP transports proteins (generally virulence-associated cell wall hydrolases) across the outer membrase of the bacterial cell. Transport across the inner membrane is often, but not exclusively handled by the Sec system. This model was constructed from the broader subfamily model, pfam00482 which includes components of pilin complexes (PilC) as well as other related genes. GspF is nearly always gene clustered with other GSP subunits. Some genes from Xylella and Xanthomonas strains score below the trusted cutoff due to excessive divergence from the family such that a sequence from Deinococcus which does not appear to be GspF scores higher. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 273980 [Multi-domain] Cd Length: 399 Bit Score: 84.30 E-value: 4.86e-18
Type II secretion system (T2SS), protein F; The original family covered both the regions found ...
224-331
1.83e-09
Type II secretion system (T2SS), protein F; The original family covered both the regions found by the current model. The splitting of the family has allowed the related FlaJ_arch (archaeal FlaJ family) to be merged with it. Proteins with this domain in form a platform for the machiney of the Type II secretion system, as well as the Type 4 pili and the archaeal flagella. This domain seems to show some similarity to PF00664 but this may just be due to similarities in the TM helices (personal obs: C Yeats).
Pssm-ID: 425708 [Multi-domain] Cd Length: 119 Bit Score: 55.03 E-value: 1.83e-09
Type II secretion system (T2SS), protein F; The original family covered both the regions found ...
16-130
3.13e-06
Type II secretion system (T2SS), protein F; The original family covered both the regions found by the current model. The splitting of the family has allowed the related FlaJ_arch (archaeal FlaJ family) to be merged with it. Proteins with this domain in form a platform for the machiney of the Type II secretion system, as well as the Type 4 pili and the archaeal flagella. This domain seems to show some similarity to PF00664 but this may just be due to similarities in the TM helices (personal obs: C Yeats).
Pssm-ID: 425708 [Multi-domain] Cd Length: 119 Bit Score: 45.79 E-value: 3.13e-06
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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