|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
11-321 |
1.49e-157 |
|
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 443.20 E-value: 1.49e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 11 IGFGGAPLGNMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYSRDDYVLSTKVGRIMLDEMEDPT 90
Cdd:cd19152 3 LGFGTAPLGNLYEAVSDEEAKATLVAAWDLGIRYFDTAPWYGAGLSEERLGAALRELGREDYVISTKVGRLLVPLQEVEP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 91 KRDFGekdgiFEHGLKNKILNDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSQDFYGDSWLEHFNTARTGAFRALTRLR 170
Cdd:cd19152 83 TFEPG-----FWNPLPFDAVFDYSYDGILRSIEDSLQRLGLSRIDLLSIHDPDEDLAGAESDEHFAQAIKGAFRALEELR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 171 EEGVIKAWGLGVNRVEPCELTlgLDEPKPDAFLLAGRYSLLDHSrALQRLMPEALEHNVDIVVGGPYSSGVLVGGEHF-- 248
Cdd:cd19152 158 EEGVIKAIGLGVNDWEVILRI--LEEADLDWVMLAGRYTLLDHS-AARELLPECEKRGVKVVNAGPFNSGFLAGGDNFdy 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1778084114 249 -EYQKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDLAALATKIPAEFWLEM 321
Cdd:cd19152 235 yEYGPAPPELIARRDRIEALCEQHGVSLAAAALQFALAPPAVASVAPGASSPERVEENVALLATEIPAAFWEEL 308
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
9-321 |
4.59e-107 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 315.03 E-value: 4.59e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGNMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYSRDDYVLSTKVGRIMLDEmed 88
Cdd:cd19161 1 SELGLGTAGLGNLYTAVSNADADATLDAAWDSGIRYFDTAPMYGHGLAEHRLGDFLREKPRDEFVLSTKVGRLLKPA--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 89 ptkRDFGEKDGI-FEHGLKNKILNDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSQDFYGDS-WLEHFNTARTGAFRAL 166
Cdd:cd19161 78 ---REGSVPDPNgFVDPLPFEIVYDYSYDGIMRSFEDSLQRLGLNRIDILYVHDIGVYTHGDRkERHHFAQLMSGGFKAL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 167 TRLREEGVIKAWGLGVNRVEPCELTlgLDEPKPDAFLLAGRYSLLDHSrALQRLMPEALEHNVDIVVGGPYSSGVLV--- 243
Cdd:cd19161 155 EELKKAGVIKAFGLGVNEVQICLEA--LDEADLDCFLLAGRYSLLDQS-AEEEFLPRCEQRGTSLVIGGVFNSGILAtgt 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1778084114 244 -GGEHFEYQKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDLAALATKIPAEFWLEM 321
Cdd:cd19161 232 kSGAKFNYGDAPAEIISRVMEIEKICDAYNVPLAAAALQFPLRHPAVASVLTGARNPAQLRQNVEAFQTDIPEELWQAL 310
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
9-320 |
8.90e-95 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 283.10 E-value: 8.90e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGNMFRAiPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYSRDDYVLSTKVGRImldeMED 88
Cdd:cd19162 1 PRLGLGAASLGNLARA-GEDEAAATLDAAWDAGIRYFDTAPLYGLGLSERRLGAALARHPRAEYVVSTKVGRL----LEP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 89 PTKRDFGEKDGIFehglknkilnDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSqdfygdswlEHFNTARTGAFRALTR 168
Cdd:cd19162 76 GAAGRPAGADRRF----------DFSADGIRRSIEASLERLGLDRLDLVFLHDPD---------RHLLQALTDAFPALEE 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 169 LREEGVIKAWGLGVNRVEpcELTLGLDEPKPDAFLLAGRYSLLDHsRALQRLMPEALEHNVDIVVGGPYSSGVLVGGE-- 246
Cdd:cd19162 137 LRAEGVVGAIGVGVTDWA--ALLRAARRADVDVVMVAGRYTLLDR-RAATELLPLCAAKGVAVVAAGVFNSGILATDDpa 213
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1778084114 247 --HFEYQKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDLAALATKIPAEFWLE 320
Cdd:cd19162 214 gdRYDYRPATPEVLARARRLAAVCRRYGVPLPAAALQFPLRHPAVASVVVGAASPAELRDNLALLRTPIPAEFWAE 289
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
9-318 |
6.88e-87 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 262.49 E-value: 6.88e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGNMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSglSEIRMGEALSQYSRDDYVLSTKVGRIMLDEmed 88
Cdd:cd19090 1 SALGLGTAGLGGVFGGVDDDEAVATIRAALDLGINYIDTAPAYGD--SEERLGLALAELPREPLVLSTKVGRLPEDT--- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 89 ptkrdfgekdgifehglknkilNDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSQdfygDSWLEhfNTARTGAFRALTR 168
Cdd:cd19090 76 ----------------------ADYSADRVRRSVEESLERLGRDRIDLLMIHDPER----VPWVD--ILAPGGALEALLE 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 169 LREEGVIKAWGLGVNRVEpcELTLGLDEPKPDAFLLAGRYSLLDHSrALQRLMPEALEHNVDIVVGGPYSSGVLVGGE-- 246
Cdd:cd19090 128 LKEEGLIKHIGLGGGPPD--LLRRAIETGDFDVVLTANRYTLLDQS-AADELLPAAARHGVGVINASPLGMGLLAGRPpe 204
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1778084114 247 --HFEYQKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDLAALATKIPAEFW 318
Cdd:cd19090 205 rvRYTYRWLSPELLDRAKRLYELCDEHGVPLPALALRFLLRDPRISTVLVGASSPEELEQNVAAAEGPLPEELW 278
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
6-318 |
3.21e-75 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 233.92 E-value: 3.21e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 6 LLPSQIGFGGAPLGNMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYSRDDYVLSTKVGRIMLDe 85
Cdd:COG0667 11 LKVSRLGLGTMTFGGPWGGVDEAEAIAILDAALDAGINFFDTADVYGPGRSEELLGEALKGRPRDDVVIATKVGRRMGP- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 86 meDPTKRdfgekdgifehglknkilnDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSQDfygdswlehfnTARTGAFRA 165
Cdd:COG0667 90 --GPNGR-------------------GLSREHIRRAVEASLRRLGTDYIDLYQLHRPDPD-----------TPIEETLGA 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 166 LTRLREEGVIKAWGLGVNRVEPCELTLGLDEPKPDAFLLAGRYSLLDHsRALQRLMPEALEHNVDIVVGGPYSSGVLVG- 244
Cdd:COG0667 138 LDELVREGKIRYIGVSNYSAEQLRRALAIAEGLPPIVAVQNEYSLLDR-SAEEELLPAARELGVGVLAYSPLAGGLLTGk 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 245 -------------GEHFEYQKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDLAALAT 311
Cdd:COG0667 217 yrrgatfpegdraATNFVQGYLTERNLALVDALRAIAAEHGVTPAQLALAWLLAQPGVTSVIPGARSPEQLEENLAAADL 296
|
....*..
gi 1778084114 312 KIPAEFW 318
Cdd:COG0667 297 ELSAEDL 303
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
9-316 |
3.48e-66 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 210.10 E-value: 3.48e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGNMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYSRDDYVLSTKVGRImldemED 88
Cdd:cd19163 14 SKLGFGASPLGGVFGPVDEEEAIRTVHEALDSGINYIDTAPWYGQGRSETVLGKALKGIPRDSYYLATKVGRY-----GL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 89 PTKRDFgekdgifehglknkilnDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSqdfYGDSWLEHFNTartgAFRALTR 168
Cdd:cd19163 89 DPDKMF-----------------DFSAERITKSVEESLKRLGLDYIDIIQVHDIE---FAPSLDQILNE----TLPALQK 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 169 LREEGVIKAWGLGVNRVEPCELTLGLDEPKPDAFLLAGRYSLLDHSraLQRLMPEALEHNVDIVVGGPYSSGVLVGGEHF 248
Cdd:cd19163 145 LKEEGKVRFIGITGYPLDVLKEVLERSPVKIDTVLSYCHYTLNDTS--LLELLPFFKEKGVGVINASPLSMGLLTERGPP 222
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1778084114 249 EYQKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDLAALATKIPAE 316
Cdd:cd19163 223 DWHPASPEIKEACAKAAAYCKSRGVDISKLALQFALSNPDIATTLVGTASPENLRKNLEAAEEPLDAH 290
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
9-308 |
3.78e-55 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 179.98 E-value: 3.78e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGNMFRAIPDD-EALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYsRDDYVLSTKVGrimldeme 87
Cdd:cd19086 4 SEIGFGTWGLGGDWWGDVDDaEAIRALRAALDLGINFFDTADVYGDGHSERLLGKALKGR-RDKVVIATKFG-------- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 88 dptkRDFGEKDGIFEhglknkilnDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSQDFYGDswlehfntarTGAFRALT 167
Cdd:cd19086 75 ----NRFDGGPERPQ---------DFSPEYIREAVEASLKRLGTDYIDLYQLHNPPDEVLDN----------DELFEALE 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 168 RLREEGVIKAWGLGVNRVEpcELTLGLDEPKPDAFLLAgrYSLLDHsRALQRLMPEALEHNVDIVVGGPYSSGVLVGgeh 247
Cdd:cd19086 132 KLKQEGKIRAYGVSVGDPE--EALAALRRGGIDVVQVI--YNLLDQ-RPEEELFPLAEEHGVGVIARVPLASGLLTG--- 203
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1778084114 248 feyqkaspaihqqvakiyQIAQqfnvdvkaAALQFSLANPAVAAVIPGSSRPGRMADDLAA 308
Cdd:cd19086 204 ------------------KLAQ--------AALRFILSHPAVSTVIPGARSPEQVEENAAA 238
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
9-308 |
7.15e-53 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 174.73 E-value: 7.15e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGNMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSglSEIRMGEALSQYSRDDYVLSTKVGrimldemed 88
Cdd:cd19095 1 SVLGLGTSGIGRVWGVPSEAEAARLLNTALDLGINLIDTAPAYGR--SEERLGRALAGLRRDDLFIATKVG--------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 89 ptkrdfgekdgifEHGLKNKILNDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSQDfygdswlehfnTARTGAFRALTR 168
Cdd:cd19095 70 -------------THGEGGRDRKDFSPAAIRASIERSLRRLGTDYIDLLQLHGPSDD-----------ELTGEVLETLED 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 169 LREEGVIKAwgLGVN-RVEPCELTLGLDEpkPDAFLLAgrYSLLDhsRALQRLMPEALEHNVDIVVGGPYSSGVLVGGEh 247
Cdd:cd19095 126 LKAAGKVRY--IGVSgDGEELEAAIASGV--FDVVQLP--YNVLD--REEEELLPLAAEAGLGVIVNRPLANGRLRRRV- 196
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1778084114 248 feyqKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDLAA 308
Cdd:cd19095 197 ----RRRPLYADYARRPEFAAEIGGATWAQAALRFVLSHPGVSSAIVGTTNPEHLEENLAA 253
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
11-318 |
2.56e-47 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 161.33 E-value: 2.56e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 11 IGFGGAPLGNMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQY--SRDDYVLSTKVGrimldeMED 88
Cdd:pfam00248 1 IGLGTWQLGGGWGPISKEEALEALRAALEAGINFIDTAEVYGDGKSEELLGEALKDYpvKRDKVVIATKVP------DGD 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 89 PTKRDFGEKDGIfehglknkilndysedatLRSIEDSLKRLKTDRIDIVWIHDPSqdfygdswlehFNTARTGAFRALTR 168
Cdd:pfam00248 75 GPWPSGGSKENI------------------RKSLEESLKRLGTDYIDLYYLHWPD-----------PDTPIEETWDALEE 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 169 LREEGVIKAWGL---GVNRVEPCELTLGLdepKPDAflLAGRYSLLDHsRALQRLMPEALEHNVDIVVGGPYSSGVLVGG 245
Cdd:pfam00248 126 LKKEGKIRAIGVsnfDAEQIEKALTKGKI---PIVA--VQVEYNLLRR-RQEEELLEYCKKNGIPLIAYSPLGGGLLTGK 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 246 EHFEYQKAS-----------PAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDLAALATKIP 314
Cdd:pfam00248 200 YTRDPDKGPgerrrllkkgtPLNLEALEALEEIAKEHGVSPAQVALRWALSKPGVTIPIPGASNPEQLEDNLGALEFPLS 279
|
....
gi 1778084114 315 AEFW 318
Cdd:pfam00248 280 DEEV 283
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
9-316 |
1.59e-42 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 148.83 E-value: 1.59e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGN-MFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYsRDDYVLSTKVGRImldeme 87
Cdd:cd19084 5 SRIGLGTWAIGGtWWGEVDDQESIEAIKAAIDLGINFFDTAPVYGFGHSEEILGKALKGR-RDDVVIATKCGLR------ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 88 dptkrdfGEKDGIFEHGLknkilndySEDATLRSIEDSLKRLKTDRIDIVWIHDPSQdfygdswlehfNTARTGAFRALT 167
Cdd:cd19084 78 -------WDGGKGVTKDL--------SPESIRKEVEQSLRRLQTDYIDLYQIHWPDP-----------NTPIEETAEALE 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 168 RLREEGVIKAWGL---GVNRVEPCELTLGLDEpkpdaflLAGRYSLLDHSRALQrLMPEALEHNVDIVVGGPYSSGVLVG 244
Cdd:cd19084 132 KLKKEGKIRYIGVsnfSVEQLEEARKYGPIVS-------LQPPYSMLEREIEEE-LLPYCRENGIGVLPYGPLAQGLLTG 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 245 ---------------------GEHFE-YQKAspaihqqVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRM 302
Cdd:cd19084 204 kykkeptfppddrrsrfpffrGENFEkNLEI-------VDKLKEIAEKYGKSLAQLAIAWTLAQPGVTSAIVGAKNPEQL 276
|
330
....*....|....
gi 1778084114 303 ADDLAALATKIPAE 316
Cdd:cd19084 277 EENAGALDWELTEE 290
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
9-307 |
5.75e-41 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 143.01 E-value: 5.75e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGNMfraiPDDEALAVVHEAWNLGIRYFDTAPLYGSglSEIRMGEALSQYsRDDYVLSTKVGrimldemed 88
Cdd:cd19100 12 SRLGFGGGPLGRL----SQEEAAAIIRRALDLGINYFDTAPSYGD--SEEKIGKALKGR-RDKVFLATKTG--------- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 89 ptkrdfgekdgifehglknkilnDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSQDFygdsWLEHFnTARTGAFRALTR 168
Cdd:cd19100 76 -----------------------ARDYEGAKRDLERSLKRLGTDYIDLYQLHAVDTEE----DLDQV-FGPGGALEALLE 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 169 LREEGVIKAWGLGVNRVEPceLTLGLDEPKPDAFLLagRYSLLDHSRALQR--LMPEALEHNVDIVVGGPYSSGVLVGGE 246
Cdd:cd19100 128 AKEEGKIRFIGISGHSPEV--LLRALETGEFDVVLF--PINPAGDHIDSFReeLLPLAREKGVGVIAMKVLAGGRLLSGD 203
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1778084114 247 HFEyqkaspaihqqvakiyqiaqqfnvdvKAAALQFSLANPAVAAVIPGSSRPGRMADDLA 307
Cdd:cd19100 204 PLD--------------------------PEQALRYALSLPPVDVVIVGMDSPEELDENLA 238
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
8-316 |
3.25e-39 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 140.03 E-value: 3.25e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 8 PSQIGFGGAPLG--NMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQySRDDYVLSTKVGrimlde 85
Cdd:cd19085 1 VSRLGLGCWQFGggYWWGDQDDEESIATIHAALDAGINFFDTAEAYGDGHSEEVLGKALKG-RRDDVVIATKVS------ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 86 medptkrdfgekdgifehglknkiLNDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSqdfygdswlEHFNTARTgaFRA 165
Cdd:cd19085 74 ------------------------PDNLTPEDVRKSCERSLKRLGTDYIDLYQIHWPS---------SDVPLEET--MEA 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 166 LTRLREEGVIKAwgLGVNRVEPCELTLGLDEPKPDAFLLAgrYSLLdhSRA-LQRLMPEALEHNVDIVVGGPYSSGVLVG 244
Cdd:cd19085 119 LEKLKEEGKIRA--IGVSNFGPAQLEEALDAGRIDSNQLP--YNLL--WRAiEYEILPFCREHGIGVLAYSPLAQGLLTG 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 245 G-----------------EHFEyQKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDLA 307
Cdd:cd19085 193 KfssaedfppgdartrlfRHFE-PGAEEETFEALEKLKEIADELGVTMAQLALAWVLQQPGVTSVIVGARNPEQLEENAA 271
|
....*....
gi 1778084114 308 ALATKIPAE 316
Cdd:cd19085 272 AVDLELSPS 280
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
9-307 |
3.47e-39 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 138.42 E-value: 3.47e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGnmfRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQY-SRDDYVLSTKVGRIMLDEME 87
Cdd:cd06660 1 SRLGLGTMTFG---GDGDEEEAFALLDAALEAGGNFFDTADVYGDGRSERLLGRWLKGRgNRDDVVIATKGGHPPGGDPS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 88 DPtkrdfgekdgifehglknkilnDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSqdfygdswlehFNTARTGAFRALT 167
Cdd:cd06660 78 RS----------------------RLSPEHIRRDLEESLRRLGTDYIDLYYLHRDD-----------PSTPVEETLEALN 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 168 RLREEGVIKAWGL---GVNRV-EPCELTLGLDEPKPDAflLAGRYSLLDHSRALQRLMPEALEHNVDIVvggPYSSgvLV 243
Cdd:cd06660 125 ELVREGKIRYIGVsnwSAERLaEALAYAKAHGLPGFAA--VQPQYSLLDRSPMEEELLDWAEENGLPLL---AYSP--LA 197
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1778084114 244 GGehfeyqkaspaihqqvakiyqIAQqfnvdvkaAALQFSLANPAVAAVIPGSSRPGRMADDLA 307
Cdd:cd06660 198 RG---------------------PAQ--------LALAWLLSQPFVTVPIVGARSPEQLEENLA 232
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
9-309 |
1.10e-38 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 139.09 E-value: 1.10e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLG--NMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYSRDDYVLSTKVGrimLDEM 86
Cdd:cd19083 12 NPIGLGTNAVGghNLYPNLDEEEGKDLVREALDNGVNLLDTAFIYGLGRSEELVGEVLKEYNRNEVVIATKGA---HKFG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 87 EDPTKRDfgekdgifehglknkilndySEDATLRS-IEDSLKRLKTDRIDIVWIHDPSQDfygdswlehfnTARTGAFRA 165
Cdd:cd19083 89 GDGSVLN--------------------NSPEFLRSaVEKSLKRLNTDYIDLYYIHFPDGE-----------TPKAEAVGA 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 166 LTRLREEGVIKAWGLGvnrvepcELTL-GLDEPKPDAFL--LAGRYSLLdHSRALQRLMPEALEHNVDIVVGGPYSSGVL 242
Cdd:cd19083 138 LQELKDEGKIRAIGVS-------NFSLeQLKEANKDGYVdvLQGEYNLL-QREAEEDILPYCVENNISFIPYFPLASGLL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 243 VGG----------------EHFEYQKASPAIHqQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDL 306
Cdd:cd19083 210 AGKytkdtkfpdndlrndkPLFKGERFSENLD-KVDKLKSIADEKGVTVAHLALAWYLTRPAIDVVIPGAKRAEQVIDNL 288
|
...
gi 1778084114 307 AAL 309
Cdd:cd19083 289 KAL 291
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
9-308 |
4.55e-37 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 135.29 E-value: 4.55e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGNMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALS--QYSRDDYVLSTKVGRImldem 86
Cdd:PLN02587 12 SSVGFGASPLGSVFGPVSEEDAIASVREAFRLGINFFDTSPYYGGTLSEKVLGKALKalGIPREKYVVSTKCGRY----- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 87 edptkrdfgeKDGIfehglknkilnDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSqdfygdswLEHFNTARTGAFRAL 166
Cdd:PLN02587 87 ----------GEGF-----------DFSAERVTKSVDESLARLQLDYVDILHCHDIE--------FGSLDQIVNETIPAL 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 167 TRLREEGviKAWGLGVNRVEPCELTLGLDEPKP---DAFLLAGRYSLLDHSraLQRLMPEALEHNVDIVVGGPYSSGVLV 243
Cdd:PLN02587 138 QKLKESG--KVRFIGITGLPLAIFTYVLDRVPPgtvDVILSYCHYSLNDSS--LEDLLPYLKSKGVGVISASPLAMGLLT 213
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1778084114 244 GGEHFEYQKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDLAA 308
Cdd:PLN02587 214 ENGPPEWHPAPPELKSACAAAATHCKEKGKNISKLALQYSLSNKDISTTLVGMNSVQQVEENVAA 278
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
9-309 |
8.03e-36 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 130.01 E-value: 8.03e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGnmfraipdDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYSRDDYVLSTKVgrimldemed 88
Cdd:cd19105 14 SRLGFGGGGLP--------RESPELLRRALDLGINYFDTAEGYGNGNSEEIIGEALKGLRRDKVFLATKA---------- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 89 PTKRDFGEKDGIfehglknkilndysedatLRSIEDSLKRLKTDRIDIVWIHDPSqdfYGDSWLEHfntarTGAFRALTR 168
Cdd:cd19105 76 SPRLDKKDKAEL------------------LKSVEESLKRLQTDYIDIYQLHGVD---TPEERLLN-----EELLEALEK 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 169 LREEGVIKAWGLGVNRVEPCELTLGLDEPKPDAFLLAgrYSLLDHSRALQRLMPEALEHNVDIVVGGPYSSGVLVGGEHF 248
Cdd:cd19105 130 LKKEGKVRFIGFSTHDNMAEVLQAAIESGWFDVIMVA--YNFLNQPAELEEALAAAAEKGIGVVAMKTLAGGYLQPALLS 207
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1778084114 249 EYQKASPAIHQqvakiyqiaqqfnvdvkaAALQFSLANPAVAAVIPGSSRPGRMADDLAAL 309
Cdd:cd19105 208 VLKAKGFSLPQ------------------AALKWVLSNPRVDTVVPGMRNFAELEENLAAA 250
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
6-317 |
8.89e-36 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 131.17 E-value: 8.89e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 6 LLPSQIGFGGAPlgNMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYSRDDYVLSTKVGrimlde 85
Cdd:cd19074 2 LKVSELSLGTWL--TFGGQVDDEDAKACVRKAYDLGINFFDTADVYAAGQAEEVLGKALKGWPRESYVISTKVF------ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 86 medptkrdFGEKDGIFEHGLKNK-ILNdysedatlrSIEDSLKRLKTDRIDIVWIH--DPsqdfygdswlehfNTARTGA 162
Cdd:cd19074 74 --------WPTGPGPNDRGLSRKhIFE---------SIHASLKRLQLDYVDIYYCHryDP-------------ETPLEET 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 163 FRALTRLREEGVIKAWglGVNRVEPCELTLGLDepKPDAFLLAG------RYSLLDHSRaLQRLMPEALEHNVDIVVGGP 236
Cdd:cd19074 124 VRAMDDLIRQGKILYW--GTSEWSAEQIAEAHD--LARQFGLIPpvveqpQYNMLWREI-EEEVIPLCEKNGIGLVVWSP 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 237 YSSGVLVGgehfEYQKASP------AIHQQ----------------VAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIP 294
Cdd:cd19074 199 LAQGLLTG----KYRDGIPppsrsrATDEDnrdkkrrlltdenlekVKKLKPIADELGLTLAQLALAWCLRNPAVSSAII 274
|
330 340
....*....|....*....|...
gi 1778084114 295 GSSRPGRMADDLAALATKIPAEF 317
Cdd:cd19074 275 GASRPEQLEENVKASGVKLSPEV 297
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
9-295 |
2.66e-34 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 127.77 E-value: 2.66e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGNMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYSrDDYVLSTKVgRIMLDEMED 88
Cdd:cd19104 13 SELTFGGGGIGGLMGRTTREEQIAAVRRALDLGINFFDTAPSYGDGKSEENLGRALKGLP-AGPYITTKV-RLDPDDLGD 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 89 ptkrdfgekdgifehgLKNKIlndysedatLRSIEDSLKRLKTDRIDIVWIHdpSQDFYGDSWLEHFNTART------GA 162
Cdd:cd19104 91 ----------------IGGQI---------ERSVEKSLKRLKRDSVDLLQLH--NRIGDERDKPVGGTLSTTdvlglgGV 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 163 FRALTRLREEGVIKAWGL-GVNRVEPCELTlgLDEPKPDAFLLAgrYSLLDHSRALQR-----------LMPEALEHNVD 230
Cdd:cd19104 144 ADAFERLRSEGKIRFIGItGLGNPPAIREL--LDSGKFDAVQVY--YNLLNPSAAEARprgwsaqdyggIIDAAAEHGVG 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1778084114 231 IVVGGPYSSGVLVG------GEHFEYQKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPG 295
Cdd:cd19104 220 VMGIRVLAAGALTTsldrgrEAPPTSDSDVAIDFRRAAAFRALAREWGETLAQLAHRFALSNPGVSTVLVG 290
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
9-308 |
1.59e-30 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 117.25 E-value: 1.59e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGNMFRAIPD-DEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALS--QYSRDDYVLSTKVGRImlde 85
Cdd:cd19153 13 SPVGLGTAALGGVYGDGLEqDEAVAIVAEAFAAGINHFDTSPYYGAESSEAVLGKALAalQVPRSSYTVATKVGRY---- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 86 medptkrdfgeKDGIFehglknkilnDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSqdfYGDswlehFNTARTGAFRA 165
Cdd:cd19153 89 -----------RDSEF----------DYSAERVRASVATSLERLHTTYLDVVYLHDIE---FVD-----YDTLVDEALPA 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 166 LTRLREEGVIKAWGLG----------VNRVEPceltlgldePKPDAFLLAGRYSLLDHsrALQRLMPEALEHNVDIVV-G 234
Cdd:cd19153 140 LRTLKDEGVIKRIGIAgypldtltraTRRCSP---------GSLDAVLSYCHLTLQDA--RLESDAPGLVRGAGPHVInA 208
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1778084114 235 GPYSSGVLVGGEHFEYQKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPA-VAAVIPGSSRPGRMADDLAA 308
Cdd:cd19153 209 SPLSMGLLTSQGPPPWHPASGELRHYAAAADAVCASVEASLPDLALQYSLAAHAgVGTVLLGPSSLAQLRSMLAA 283
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
9-314 |
4.73e-28 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 109.92 E-value: 4.73e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLG------NMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSglSEIRMGEALSQYsrDDYVLSTKVGrim 82
Cdd:cd19097 1 SKLALGTAQFGldygiaNKSGKPSEKEAKKILEYALKAGINTLDTAPAYGD--SEKVLGKFLKRL--DKFKIITKLP--- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 83 ldemedptkrdfgekdgifehglKNKILNDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSQ-DFYGDSWLEhfntartg 161
Cdd:cd19097 74 -----------------------PLKEDKKEDEAAIEASVEASLKRLKVDSLDGLLLHNPDDlLKHGGKLVE-------- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 162 afrALTRLREEGVIKAWGLGVNRVEpcELTLGLDEPKPDAFLLAgrYSLLDHsRALQR-LMPEALEHNVDIVVGGPYSSG 240
Cdd:cd19097 123 ---ALLELKKEGLIRKIGVSVYSPE--ELEKALESFKIDIIQLP--FNILDQ-RFLKSgLLAKLKKKGIEIHARSVFLQG 194
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1778084114 241 VLVgGEHFEYQKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDLAALATKIP 314
Cdd:cd19097 195 LLL-MEPDKLPAKFAPAKPLLKKLHELAKKLGLSPLELALGFVLSLPEIDKIVVGVDSLEQLKEIIAAFKKPPL 267
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
9-299 |
9.77e-28 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 110.10 E-value: 9.77e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGNMFRAipDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQY------SRDDYVLSTKVGRIM 82
Cdd:cd19099 4 SSLGLGTYRGDSDDET--DEEYREALKAALDSGINVIDTAINYRGGRSERLIGKALRELiekggiKRDEVVIVTKAGYIP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 83 LDEMEDPTKRDFGEKDGIfehglknKILNDYSEDATLR----------SIEDSLKRLKTDRIDIVWIHDPSQDFYGDSwL 152
Cdd:cd19099 82 GDGDEPLRPLKYLEEKLG-------RGLIDVADSAGLRhcispayledQIERSLKRLGLDTIDLYLLHNPEEQLLELG-E 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 153 EHFNTARTGAFRALTRLREEGVIKAWGLGVN---RVEPCELTLGLDEPKPDAFLLAGRYslLDHSRALQ----RLMPEAL 225
Cdd:cd19099 154 EEFYDRLEEAFEALEEAVAEGKIRYYGISTWdgfRAPPALPGHLSLEKLVAAAEEVGGD--NHHFKVIQlplnLLEPEAL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 226 ------------------EHNVDIVVGGPYSSGVLVGGehfeyqkaspaihqqVAKIYQIAQQFNVDVKAAALQFSLANP 287
Cdd:cd19099 232 tekntvkgealslleaakELGLGVIASRPLNQGQLLGE---------------LRLADLLALPGGATLAQRALQFARSTP 296
|
330
....*....|..
gi 1778084114 288 AVAAVIPGSSRP 299
Cdd:cd19099 297 GVDSALVGMRRP 308
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
9-316 |
1.11e-27 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 109.68 E-value: 1.11e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGNMFRAIP-----DDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYSRDDYVlSTKVGRIML 83
Cdd:cd19102 2 TTIGLGTWAIGGGGWGGGwgpqdDRDSIAAIRAALDLGINWIDTAAVYGLGHSEEVVGRALKGLRDRPIV-ATKCGLLWD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 84 DEmedptkrdfgekdgifehglkNKILNDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSqdfyGDSWLEHfntartgAF 163
Cdd:cd19102 81 EE---------------------GRIRRSLKPASIRAECEASLRRLGVDVIDLYQIHWPD----PDEPIEE-------AW 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 164 RALTRLREEGVIKAWGLG---VNRVEPCELTLGLDEPKPdafllagRYSLLDHSrALQRLMPEALEHNVDIVVGGPYSSG 240
Cdd:cd19102 129 GALAELKEEGKVRAIGVSnfsVDQMKRCQAIHPIASLQP-------PYSLLRRG-IEAEILPFCAEHGIGVIVYSPMQSG 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 241 VLVGGEHFEYQKASPA-----------------IHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMA 303
Cdd:cd19102 201 LLTGKMTPERVASLPAddwrrrspffqepnlarNLALVDALRPIAERHGRTVAQLAIAWVLRRPEVTSAIVGARRPDQID 280
|
330
....*....|...
gi 1778084114 304 DDLAALATKIPAE 316
Cdd:cd19102 281 ETVGAADLRLTPE 293
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
9-316 |
1.26e-27 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 109.67 E-value: 1.26e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGN--MFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYsRDDYVLSTKVGrIMLDem 86
Cdd:cd19149 12 SVIGLGTWAIGGgpWWGGSDDNESIRTIHAALDLGINLIDTAPAYGFGHSEEIVGKAIKGR-RDKVVLATKCG-LRWD-- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 87 edptkrdfgEKDGIFEHGLKNKILNDYSEDATLR-SIEDSLKRLKTDRIDIVWIHDPSQDF-YGDSWlehfntartgafR 164
Cdd:cd19149 88 ---------REGGSFFFVRDGVTVYKNLSPESIReEVEQSLKRLGTDYIDLYQTHWQDVETpIEETM------------E 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 165 ALTRLREEGVIKAwgLGVNRVEPCELtlgldepkpDAFLLAG-------RYSLLDhsRAL-QRLMPEALEHNVDIVVGGP 236
Cdd:cd19149 147 ALEELKRQGKIRA--IGASNVSVEQI---------KEYVKAGqldiiqeKYSMLD--RGIeKELLPYCKKNNIAFQAYSP 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 237 YSSGVLVG----GEHFEYQKA-------SPAIHQQVA----KIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGR 301
Cdd:cd19149 214 LEQGLLTGkitpDREFDAGDArsgipwfSPENREKVLalleKWKPLCEKYGCTLAQLVIAWTLAQPGITSALCGARKPEQ 293
|
330
....*....|....*
gi 1778084114 302 MADDLAALATKIPAE 316
Cdd:cd19149 294 AEENAKAGDIRLSAE 308
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
9-316 |
1.37e-26 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 107.98 E-value: 1.37e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGaplgnM-FRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSglSEIRMGEALSQYsRDDYVLSTKVgrimldeme 87
Cdd:COG1453 14 SVLGFGG-----MrLPRKDEEEAEALIRRAIDNGINYIDTARGYGD--SEEFLGKALKGP-RDKVILATKL--------- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 88 DPTKRDFgekdgifehglknkilndysEDAtLRSIEDSLKRLKTDRIDIVWIHdpsqdfyGDSWLEHFNTA--RTGAFRA 165
Cdd:COG1453 77 PPWVRDP--------------------EDM-RKDLEESLKRLQTDYIDLYLIH-------GLNTEEDLEKVlkPGGALEA 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 166 LTRLREEGVIKAwgLGV---NRVEPCELTlgLDEPKPDAFLLagRYSLLD-HSRALQRLMPEALEHNVDIVVGGPYSSGV 241
Cdd:COG1453 129 LEKAKAEGKIRH--IGFsthGSLEVIKEA--IDTGDFDFVQL--QYNYLDqDNQAGEEALEAAAEKGIGVIIMKPLKGGR 202
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1778084114 242 LvggehfeyqkasPAIHQQVAKIYQIaqqfNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDLAALATKIPAE 316
Cdd:COG1453 203 L------------ANPPEKLVELLCP----PLSPAEWALRFLLSHPEVTTVLSGMSTPEQLDENLKTADNLEPLT 261
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
27-316 |
8.29e-26 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 104.58 E-value: 8.29e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 27 DDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQySRDDYVLSTKVGrimldemeDPTKrdfgekDGIFEHGLk 106
Cdd:cd19087 29 EETSFAIMDRALDAGINFFDTADVYGGGRSEEIIGRWIAG-RRDDIVLATKVF--------GPMG------DDPNDRGL- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 107 nkilndySEDATLRSIEDSLKRLKTDRIDIVWIH--DPSQdfygdSWLEhfntartgAFRALTRLREEGVIK-------- 176
Cdd:cd19087 93 -------SRRHIRRAVEASLRRLQTDYIDLYQMHhfDRDT-----PLEE--------TLRALDDLVRQGKIRyigvsnfa 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 177 AW----GLGVNRVEPcelTLGLDEPKPdafllagRYSLLDHsRALQRLMPEALEHNVDIVV---------GGPY------ 237
Cdd:cd19087 153 AWqiakAQGIAARRG---LLRFVSEQP-------MYNLLKR-QAELEILPAARAYGLGVIPysplaggllTGKYgkgkrp 221
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1778084114 238 SSGVLVGGEHFEYQKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDLAALATKIPAE 316
Cdd:cd19087 222 ESGRLVERARYQARYGLEEYRDIAERFEALAAEAGLTPASLALAWVLSHPAVTSPIIGPRTLEQLEDSLAALEITLTPE 300
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
4-284 |
1.50e-25 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 103.90 E-value: 1.50e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 4 KKLLPSQIgFGGAPLGNMFRAIPDD-EALAVVHEAWNLGIRYFDTAPLYGSglSEIRMGEALS----QYSRDDYVLSTKV 78
Cdd:cd19164 10 LAGLPPLI-FGAATFSYQYTTDPESiPPVDIVRRALELGIRAFDTSPYYGP--SEIILGRALKalrdEFPRDTYFIITKV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 79 GRIMLDemedptkrDFgekdgifehglknkilnDYSEDATLRSIEDSLKRLKTDRIDIVWIHDpsQDFYGDSWLehfnta 158
Cdd:cd19164 87 GRYGPD--------DF-----------------DYSPEWIRASVERSLRRLHTDYLDLVYLHD--VEFVADEEV------ 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 159 rTGAFRALTRLREEGVIKAWG-----LGVnRVEPCELTLGLDEPKPDAFLLAGRYSLldHSRALqrlmPEALEHNVD--- 230
Cdd:cd19164 134 -LEALKELFKLKDEGKIRNVGisgypLPV-LLRLAELARTTAGRPLDAVLSYCHYTL--QNTTL----LAYIPKFLAaag 205
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1778084114 231 ---IVVGGPYSSGVLVGGEHFEYQKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSL 284
Cdd:cd19164 206 vkvVLNASPLSMGLLRSQGPPEWHPASPELRAAAAKAAEYCQAKGTDLADVALRYAL 262
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
9-323 |
2.96e-25 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 103.43 E-value: 2.96e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGNMFRA---IPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQY-SRDDYVLSTKVGrimld 84
Cdd:cd19079 13 SRLCLGCMSFGDPKWRpwvLDEEESRPIIKRALDLGINFFDTANVYSGGASEEILGRALKEFaPRDEVVIATKVY----- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 85 emedptkrdFGEKDGIFEHGLKNKilndysedATLRSIEDSLKRLKTDRIDIVWIHdpsqdfygdSWleHFNTARTGAFR 164
Cdd:cd19079 88 ---------FPMGDGPNGRGLSRK--------HIMAEVDASLKRLGTDYIDLYQIH---------RW--DYETPIEETLE 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 165 ALTRLREEGviKAWGLGVNRVEPCELTlgldepkpDAFLLAGRY------SLLDHSRALQR-----LMPEALEHNVDIVV 233
Cdd:cd19079 140 ALHDVVKSG--KVRYIGASSMYAWQFA--------KALHLAEKNgwtkfvSMQNHYNLLYReeereMIPLCEEEGIGVIP 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 234 GGPYSSGVLVG--------------GEHFEYQKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRP 299
Cdd:cd19079 210 WSPLARGRLARpwgdtterrrsttdTAKLKYDYFTEADKEIVDRVEEVAKERGVSMAQVALAWLLSKPGVTAPIVGATKL 289
|
330 340
....*....|....*....|....
gi 1778084114 300 GRMADDLAALATKIPAEfwlEMQR 323
Cdd:cd19079 290 EHLEDAVAALDIKLSEE---EIKY 310
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
8-304 |
2.68e-24 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 100.46 E-value: 2.68e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 8 PSQIGFGG-APLGNMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQY-SRDDYVLSTKVGrimlde 85
Cdd:cd19148 4 VSRIALGTwAIGGWMWGGTDEKEAIETIHKALDLGINLIDTAPVYGFGLSEEIVGKALKEYgKRDRVVIATKVG------ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 86 medptkRDFGEKDGIFEHGLKNKIlndysedatLRSIEDSLKRLKTDRIDIVWIH--DPSQDFYgdswlehfNTArtgaf 163
Cdd:cd19148 78 ------LEWDEGGEVVRNSSPARI---------RKEVEDSLRRLQTDYIDLYQVHwpDPLVPIE--------ETA----- 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 164 RALTRLREEGVIKAwgLGVNRVEPceltlgldePKPDAFLLAGR-------YSLLDhsRALQR-LMPEALEHNVDIVVGG 235
Cdd:cd19148 130 EALKELLDEGKIRA--IGVSNFSP---------EQMETFRKVAPlhtvqppYNLFE--REIEKdVLPYARKHNIVTLAYG 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 236 PYSSGVLVGGEHFEYQ-------KASPAIHQQ--------VAKIYQIAQQ-FNVDVKAAALQFSLANPAVAAVIPGSSRP 299
Cdd:cd19148 197 ALCRGLLSGKMTKDTKfegddlrRTDPKFQEPrfsqylaaVEELDKLAQErYGKSVIHLAVRWLLDQPGVSIALWGARKP 276
|
....*
gi 1778084114 300 GRMAD 304
Cdd:cd19148 277 EQLDA 281
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
9-316 |
2.85e-24 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 100.72 E-value: 2.85e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGNmfraiPDDEALAvvHE----AWNLGIRYFDTAPLY-------GSGLSEIRMGEAL-SQYSRDDYVLST 76
Cdd:cd19094 2 SEICLGTMTWGE-----QNTEAEA--HEqldyAFDEGVNFIDTAEMYpvppspeTQGRTEEIIGSWLkKKGNRDKVVLAT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 77 KVGrimldemedptkrdfGEKDGIFEHGLKNKILNdysEDATLRSIEDSLKRLKTDRIDIVWIHDPSQDFYGDSWLEHFN 156
Cdd:cd19094 75 KVA---------------GPGEGITWPRGGGTRLD---RENIREAVEGSLKRLGTDYIDLYQLHWPDRYTPLFGGGYYTE 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 157 TARTGAF-------RALTRLREEGVIKAWGL------GVNRVepCEL--TLGLdePKPDAflLAGRYSLLDhsRALQRLM 221
Cdd:cd19094 137 PSEEEDSvsfeeqlEALGELVKAGKIRHIGLsnetpwGVMKF--LELaeQLGL--PRIVS--IQNPYSLLN--RNFEEGL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 222 PEALEH-NVDIVVGGPYSSGVLVG----------------GEHFEYQKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSL 284
Cdd:cd19094 209 AEACHReNVGLLAYSPLAGGVLTGkyldgaarpeggrlnlFPGYMARYRSPQALEAVAEYVKLARKHGLSPAQLALAWVR 288
|
330 340 350
....*....|....*....|....*....|..
gi 1778084114 285 ANPAVAAVIPGSSRPGRMADDLAALATKIPAE 316
Cdd:cd19094 289 SRPFVTSTIIGATTLEQLKENIDAFDVPLSDE 320
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
9-310 |
4.38e-24 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 98.79 E-value: 4.38e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGG--APLGNMfRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYSRDDYVLSTKvgrimLDEM 86
Cdd:cd19096 1 SVLGFGTmrLPESDD-DSIDEEKAIEMIRYAIDAGINYFDTAYGYGGGKSEEILGEALKEGPREKFYLATK-----LPPW 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 87 EDPTKRDFgekdgifehglknkilndysedatLRSIEDSLKRLKTDRIDIVWIHDPSQdfygDSWLEHFNtaRTGAFRAL 166
Cdd:cd19096 75 SVKSAEDF------------------------RRILEESLKRLGVDYIDFYLLHGLNS----PEWLEKAR--KGGLLEFL 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 167 TRLREEGVIKAWGL-------GVNRVepceltlgLDEPKPDAFLLAgrYSLLD-HSRALQRLMPEALEHNVDIVVGGPYS 238
Cdd:cd19096 125 EKAKKEGLIRHIGFsfhdspeLLKEI--------LDSYDFDFVQLQ--YNYLDqENQAGRPGIEYAAKKGMGVIIMEPLK 194
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1778084114 239 SGVLVggehfeyQKASPAIhqqvakiyQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDLAALA 310
Cdd:cd19096 195 GGGLA-------NNPPEAL--------AILCGAPLSPAEWALRFLLSHPEVTTVLSGMSTPEQLDENIAAAD 251
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
10-323 |
1.40e-23 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 97.43 E-value: 1.40e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 10 QIGFGgaplgnMFRaIPDDEALAVVHEAWNLGIRYFDTAPLYGSglsEIRMGEAL--SQYSRDDYVLSTKVGRimldeme 87
Cdd:COG0656 7 ALGLG------TWQ-LPGEEAAAAVRTALEAGYRHIDTAAMYGN---EEGVGEAIaaSGVPREELFVTTKVWN------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 88 dptkrdfgekdgifehglknkilNDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSQDFYGDSWlehfntartgafRALT 167
Cdd:COG0656 70 -----------------------DNHGYDDTLAAFEESLERLGLDYLDLYLIHWPGPGPYVETW------------RALE 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 168 RLREEGVIKAWG------------LGVNRVEP----CELTLGLDEPKpdafllagrysLLDHSRalqrlmpealEHnvDI 231
Cdd:COG0656 115 ELYEEGLIRAIGvsnfdpehleelLAETGVKPavnqVELHPYLQQRE-----------LLAFCR----------EH--GI 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 232 VVGGpYSSgvLVGGEHFEyqkaSPAIHqqvakiyQIAQQFNVDVKAAALQFSLANPAVaaVIPGSSRPGRMADDLAALAT 311
Cdd:COG0656 172 VVEA-YSP--LGRGKLLD----DPVLA-------EIAEKHGKTPAQVVLRWHLQRGVV--VIPKSVTPERIRENLDAFDF 235
|
330
....*....|..
gi 1778084114 312 KIPAEfwlEMQR 323
Cdd:COG0656 236 ELSDE---DMAA 244
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
9-320 |
1.47e-23 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 98.01 E-value: 1.47e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGNMFraIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYS--RDDYVLSTKVGrIMLDEM 86
Cdd:cd19092 7 SRLVLGCMRLADWG--ESAEELLSLIEAALELGITTFDHADIYGGGKCEELFGEALALNPglREKIEIQTKCG-IRLGDD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 87 EDPTKrdfgekdgiFEHglknkilNDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPsqdfygDSWLEHFNTArtgafRAL 166
Cdd:cd19092 84 PRPGR---------IKH-------YDTSKEHILASVEGSLKRLGTDYLDLLLLHRP------DPLMDPEEVA-----EAF 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 167 TRLREEGVIKAwgLGVNRVEPCELTL---GLDEPkpdafLLAG--RYSLLDHSRALQRLMPEALEHNVDIVVGGPYSSGV 241
Cdd:cd19092 137 DELVKSGKVRY--FGVSNFTPSQIELlqsYLDQP-----LVTNqiELSLLHTEAIDDGTLDYCQLLDITPMAWSPLGGGR 209
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1778084114 242 LVGGEHFEYQKAspaihqqVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDLAALATKIPAEFWLE 320
Cdd:cd19092 210 LFGGFDERFQRL-------RAALEELAEEYGVTIEAIALAWLLRHPARIQPILGTTNPERIRSAVKALDIELTREEWYE 281
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
9-320 |
1.70e-22 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 95.37 E-value: 1.70e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFG----GAPLGNMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYS-RDDYVLSTKVGriml 83
Cdd:cd19093 3 SPLGLGtwqwGDRLWWGYGEYGDEDLQAAFDAALEAGVNLFDTAEVYGTGRSERLLGRFLKELGdRDEVVIATKFA---- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 84 demedPTKRDFGEKDgifehglknkilndysedaTLRSIEDSLKRLKTDRIDIVWIHdpsqdfygdsWLEHFNTARTGAF 163
Cdd:cd19093 79 -----PLPWRLTRRS-------------------VVKALKASLERLGLDSIDLYQLH----------WPGPWYSQIEALM 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 164 RALTRLREEGVIKAWGL---GVNRVEPC-ELTLGLDEPkpdaflLAG---RYSLLDHSRALQRLMPEALEHNVDIVVGGP 236
Cdd:cd19093 125 DGLADAVEEGLVRAVGVsnySADQLRRAhKALKERGVP------LASnqvEYSLLYRDPEQNGLLPACDELGITLIAYSP 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 237 YSSGVLVG------------GEHFeYQKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAavIPGSSRPGRMAD 304
Cdd:cd19093 199 LAQGLLTGkyspenpppggrRRLF-GRKNLEKVQPLLDALEEIAEKYGKTPAQVALNWLIAKGVVP--IPGAKNAEQAEE 275
|
330
....*....|....*.
gi 1778084114 305 DLAALATKIPAEFWLE 320
Cdd:cd19093 276 NAGALGWRLSEEEVAE 291
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
9-323 |
2.01e-22 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 95.38 E-value: 2.01e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGNMFRAIPD-DEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYsRDDYVLSTKvgrimldeme 87
Cdd:cd19078 5 SAIGLGCMGMSHGYGPPPDkEEMIELIRKAVELGITFFDTAEVYGPYTNEELVGEALKPF-RDQVVIATK---------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 88 dptkrdFGEKdgiFEHGLKNKILNDYSEDATLRSIEDSLKRLKTDRIDIVWIH--DPsqdfygdswlehfNTARTGAFRA 165
Cdd:cd19078 74 ------FGFK---IDGGKPGPLGLDSRPEHIRKAVEGSLKRLQTDYIDLYYQHrvDP-------------NVPIEEVAGT 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 166 LTRLREEGVIKAWGL---GVNRV----EPCELTlgldepkpdafLLAGRYSLLdHSRALQRLMPEALEHNVDIVVGGPYS 238
Cdd:cd19078 132 MKELIKEGKIRHWGLseaGVETIrrahAVCPVT-----------AVQSEYSMM-WREPEKEVLPTLEELGIGFVPFSPLG 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 239 SGVLVG----GEHFE-----------YQKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMA 303
Cdd:cd19078 200 KGFLTGkideNTKFDegddraslprfTPEALEANQALVDLLKEFAEEKGATPAQIALAWLLAKKPWIVPIPGTTKLSRLE 279
|
330 340
....*....|....*....|
gi 1778084114 304 DDLAALATKIPAEFWLEMQR 323
Cdd:cd19078 280 ENIGAADIELTPEELREIED 299
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
9-310 |
2.73e-22 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 93.82 E-value: 2.73e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPL---GNMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYSrDDYVLSTKVGrimlde 85
Cdd:cd19088 2 SRLGYGAMRLtgpGIWGPPADREEAIAVLRRALELGVNFIDTADSYGPDVNERLIAEALHPYP-DDVVIATKGG------ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 86 medpTKRDfgeKDGIFEHglknkilnDYSEDATLRSIEDSLKRLKTDRIDIVWIH--DPSQDFyGDSwlehfntartgaF 163
Cdd:cd19088 75 ----LVRT---GPGWWGP--------DGSPEYLRQAVEASLRRLGLDRIDLYQLHriDPKVPF-EEQ------------L 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 164 RALTRLREEGVIKAwgLGVNRVEPCELTLGLDEPKPDAflLAGRYSLLDhsRALQRLMPEALEHNVDIVVGGPYSSGvlv 243
Cdd:cd19088 127 GALAELQDEGLIRH--IGLSNVTVAQIEEARAIVRIVS--VQNRYNLAN--RDDEGVLDYCEAAGIAFIPWFPLGGG--- 197
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1778084114 244 ggehfeyqkaspAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDLAALA 310
Cdd:cd19088 198 ------------DLAQPGGLLAEVAARLGATPAQVALAWLLARSPVMLPIPGTSSVEHLEENLAAAG 252
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
6-316 |
3.04e-22 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 94.99 E-value: 3.04e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 6 LLPSQIGFGGAPLG---NMFRAIPD---DEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYsRDDYVLSTKVG 79
Cdd:cd19091 11 LKVSELALGTMTFGgggGFFGAWGGvdqEEADRLVDIALDAGINFFDTADVYSEGESEEILGKALKGR-RDDVLIATKVR 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 80 RIMldemedptkrdfgeKDGIFEHGLknkilndySEDATLRSIEDSLKRLKTDRIDIVWIHDPsqdfygDSWLEHFNTAr 159
Cdd:cd19091 90 GRM--------------GEGPNDVGL--------SRHHIIRAVEASLKRLGTDYIDLYQLHGF------DALTPLEETL- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 160 tgafRALTRLREEGVIK--------AWGLGVnrvepcelTLGLDE----PKPDAflLAGRYSLLdhSRALQR-LMPEALE 226
Cdd:cd19091 141 ----RALDDLVRQGKVRyigvsnfsAWQIMK--------ALGISErrglARFVA--LQAYYSLL--GRDLEHeLMPLALD 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 227 HNVDIVVGGPYSSGVLVGgehfEYQKASPA--------------------IHQQVAKIYQIAQQFNVDVKAAALQFSLAN 286
Cdd:cd19091 205 QGVGLLVWSPLAGGLLSG----KYRRGQPApegsrlrrtgfdfppvdrerGYDVVDALREIAKETGATPAQVALAWLLSR 280
|
330 340 350
....*....|....*....|....*....|
gi 1778084114 287 PAVAAVIPGSSRPGRMADDLAALATKIPAE 316
Cdd:cd19091 281 PTVSSVIIGARNEEQLEDNLGAAGLSLTPE 310
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
9-316 |
6.74e-21 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 91.12 E-value: 6.74e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGNMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYsRDDYVLSTKVGrimldemed 88
Cdd:cd19076 13 SALGLGCMGMSAFYGPADEEESIATLHRALELGVTFLDTADMYGPGTNEELLGKALKDR-RDEVVIATKFG--------- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 89 PTKRDFGEKDGIfehglknkilnDYSEDATLRSIEDSLKRLKTDRIDIVWIH--DPsqdfygdswlehfNTARTGAFRAL 166
Cdd:cd19076 83 IVRDPGSGFRGV-----------DGRPEYVRAACEASLKRLGTDVIDLYYQHrvDP-------------NVPIEETVGAM 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 167 TRLREEGVIKAwglgvnrvepceltLGLDEPKPDAFLLAGR----------YSLLdhSRALQR-LMPEALEHNVDIVVGG 235
Cdd:cd19076 139 AELVEEGKVRY--------------IGLSEASADTIRRAHAvhpitavqseYSLW--TRDIEDeVLPTCRELGIGFVAYS 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 236 PYSSGVLVG---------------------GEHFEYQKaspaihQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIP 294
Cdd:cd19076 203 PLGRGFLTGaikspedlpeddfrrnnprfqGENFDKNL------KLVEKLEAIAAEKGCTPAQLALAWVLAQGDDIVPIP 276
|
330 340
....*....|....*....|..
gi 1778084114 295 GSSRPGRMADDLAALATKIPAE 316
Cdd:cd19076 277 GTKRIKYLEENVGALDVVLTPE 298
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
27-323 |
5.58e-19 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 85.73 E-value: 5.58e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 27 DDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQySRDDYVLSTKVGriMLDEMEDPTKRDFGEKdgifehglk 106
Cdd:cd19080 30 REEARAMFDAYVEAGGNFIDTANNYTNGTSERLLGEFIAG-NRDRIVLATKYT--MNRRPGDPNAGGNHRK--------- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 107 nkilndysedATLRSIEDSLKRLKTDRIDIVWIHdpsqdfygdSWleHFNTARTGAFRALTRLREEGVIKAWGLG----- 181
Cdd:cd19080 98 ----------NLRRSVEASLRRLQTDYIDLLYVH---------AW--DFTTPVEEVMRALDDLVRAGKVLYVGISdtpaw 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 182 -VNRVEpcelTLGLDEPKPDAFLLAGRYSLLDhsRALQR-LMPEALEHNVDIVVGGPYSSGVLVGGEHFEYQ-------- 251
Cdd:cd19080 157 vVARAN----TLAELRGWSPFVALQIEYSLLE--RTPEReLLPMARALGLGVTPWSPLGGGLLTGKYQRGEEgrageakg 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1778084114 252 ------KASPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDLAALATKIPAEfwlEMQR 323
Cdd:cd19080 231 vtvgfgKLTERNWAIVDVVAAVAEELGRSAAQVALAWVRQKPGVVIPIIGARTLEQLKDNLGALDLTLSPE---QLAR 305
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
9-323 |
6.58e-18 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 81.89 E-value: 6.58e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGNMFRAIPDD--EALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYSRDDYVLSTKVgrimldem 86
Cdd:cd19072 5 PVLGLGTWGIGGGMSKDYSDdkKAIEALRYAIELGINLIDTAEMYGGGHAEELVGKAIKGFDREDLFITTKV-------- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 87 eDPTKrdfgekdgifehglknkilndYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSqdfygdswlehFNTARTGAFRAL 166
Cdd:cd19072 77 -SPDH---------------------LKYDDVIKAAKESLKRLGTDYIDLYLIHWPN-----------PSIPIEETLRAM 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 167 TRLREEGVIKAWGLGVNRVEPCELTLGLDEPKPDAFLLAgRYSLLDHsRALQRLMPEALEHNVDIVVGGPYSSGVLVGGE 246
Cdd:cd19072 124 EELVEEGKIRYIGVSNFSLEELEEAQSYLKKGPIVANQV-EYNLFDR-EEESGLLPYCQKNGIAIIAYSPLEKGKLSNAK 201
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1778084114 247 hfeyqkaspaihqQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAvIPGSSRPGRMADDLAALATKIPAEfwlEMQR 323
Cdd:cd19072 202 -------------GSPLLDEIAKKYGKTPAQIALNWLISKPNVIA-IPKASNIEHLEENAGALGWELSEE---DLQR 261
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
28-309 |
7.80e-18 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 82.64 E-value: 7.80e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 28 DEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQ--YSRDDYVLSTKVGrimldemedptkrdFGEKDGIF-EHG 104
Cdd:cd19143 31 DEAKECMKAAYDAGVNFFDNAEVYANGQSEEIMGQAIKElgWPRSDYVVSTKIF--------------WGGGGPPPnDRG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 105 LKNKILndysedatLRSIEDSLKRLKTDRIDIVWIH--DPsqdfygdswlehfNTARTGAFRALTRLREEGVIKAWGL-- 180
Cdd:cd19143 97 LSRKHI--------VEGTKASLKRLQLDYVDLVFCHrpDP-------------ATPIEETVRAMNDLIDQGKAFYWGTse 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 181 --GVNRVEPCELT--LGLDEP---KPDafllagrYSLLDHSRALQRLMPEALEHNVDIVVGGPYSSGVLVGG-------- 245
Cdd:cd19143 156 wsAQQIEEAHEIAdrLGLIPPvmeQPQ-------YNLFHRERVEVEYAPLYEKYGLGTTTWSPLASGLLTGKynngipeg 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1778084114 246 -----EHFEYQKAS-----PAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDLAAL 309
Cdd:cd19143 229 srlalPGYEWLKDRkeelgQEKIEKVRKLKPIAEELGCSLAQLAIAWCLKNPNVSTVITGATKVEQLEENLKAL 302
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
6-308 |
8.57e-18 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 82.26 E-value: 8.57e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 6 LLPSQIGFGGaplgNMFRAIPDDEALAVVHEAW-NLGIRYFDTAPLYGS-------GLSEIRMGEAL-SQYSRDDYVLST 76
Cdd:cd19081 7 LSVSPLCLGT----MVFGWTADEETSFALLDAFvDAGGNFIDTADVYSAwvpgnagGESETIIGRWLkSRGKRDRVVIAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 77 KVGRIMLDEMEdptkrdfgekdgifehGLknkilndySEDATLRSIEDSLKRLKTDRIDIVWIHDPSQDFYGDSWLehfn 156
Cdd:cd19081 83 KVGFPMGPNGP----------------GL--------SRKHIRRAVEASLRRLQTDYIDLYQAHWDDPATPLEETL---- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 157 tartgafRALTRLREEGVIKAwgLGVNRVEPCELTLGLD------EPKPDAflLAGRYSLLDHSRALQRLMPEALEHNVD 230
Cdd:cd19081 135 -------GALNDLIRQGKVRY--IGASNYSAWRLQEALElsrqhgLPRYVS--LQPEYNLVDRESFEGELLPLCREEGIG 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 231 IVvggPYS---SGVLVG-------------GEHFEYQKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIP 294
Cdd:cd19081 204 VI---PYSplaGGFLTGkyrseadlpgstrRGEAAKRYLNERGLRILDALDEVAAEHGATPAQVALAWLLARPGVTAPIA 280
|
330
....*....|....
gi 1778084114 295 GSSRPGRMADDLAA 308
Cdd:cd19081 281 GARTVEQLEDLLAA 294
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
10-323 |
3.32e-17 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 79.83 E-value: 3.32e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 10 QIGFGGAPLgnmfraiPDDEALAVVHEAWNLGIRYFDTAPLYGSglsEIRMGEALSQY--SRDDYVLSTKVGRimldeme 87
Cdd:cd19071 3 LIGLGTYKL-------KPEETAEAVLAALEAGYRHIDTAAAYGN---EAEVGEAIRESgvPREELFITTKLWP------- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 88 dptkrdfgekdgifehglknkilNDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSQDFYGDSwlehfNTARTGAFRALT 167
Cdd:cd19071 66 -----------------------TDHGYERVREALEESLKDLGLDYLDLYLIHWPVPGKEGGS-----KEARLETWRALE 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 168 RLREEGVIKAwgLGVNRVEPCELT--LGLDEPKPDafLLAGRYSLLDHSRALQRLmpeALEHNVDIVVGGPYSSGVLVGG 245
Cdd:cd19071 118 ELVDEGLVRS--IGVSNFNVEHLEelLAAARIKPA--VNQIELHPYLQQKELVEF---CKEHGIVVQAYSPLGRGRRPLL 190
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1778084114 246 EHfeyqkasPAIHqqvakiyQIAQQFNVDVKAAALQFSLANPAVaaVIPGSSRPGRMADDLAALATKIPAEfwlEMQR 323
Cdd:cd19071 191 DD-------PVLK-------EIAKKYGKTPAQVLLRWALQRGVV--VIPKSSNPERIKENLDVFDFELSEE---DMAA 249
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
10-323 |
5.97e-17 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 79.34 E-value: 5.97e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 10 QIGFGgaplgnmFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSglsEIRMGEAL--SQYSRDDYVLSTKvgrimldeme 87
Cdd:cd19131 12 QLGLG-------VWQVSNDEAASAVREALEVGYRSIDTAAIYGN---EEGVGKAIraSGVPREELFITTK---------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 88 dptkrdfgekdgifehgLKNkilNDYSEDATLRSIEDSLKRLKTDRIDIVWIH--DPSQDFYGDSWlehfntartgafRA 165
Cdd:cd19131 72 -----------------LWN---SDQGYDSTLRAFDESLRKLGLDYVDLYLIHwpVPAQDKYVETW------------KA 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 166 LTRLREEGVIKAwgLGVNRVEPCELTLGLDE----PKPDAFLLagryslldHSRALQRLMPEALE-HNVDIVVGGPYSSG 240
Cdd:cd19131 120 LIELKKEGRVKS--IGVSNFTIEHLQRLIDEtgvvPVVNQIEL--------HPRFQQRELRAFHAkHGIQTESWSPLGQG 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 241 VLVggehfeyqkASPAIHqqvakiyQIAQQFNVDVKAAALQFSLANPAVaaVIPGSSRPGRMADDLAALATKIPAEfwlE 320
Cdd:cd19131 190 GLL---------SDPVIG-------EIAEKHGKTPAQVVIRWHLQNGLV--VIPKSVTPSRIAENFDVFDFELDAD---D 248
|
...
gi 1778084114 321 MQR 323
Cdd:cd19131 249 MQA 251
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
9-309 |
1.10e-16 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 79.13 E-value: 1.10e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGNMfraIPDDEALAVVHEAWNLGIRYFDTAPLYGS----GLSEIRMGEALSQYS-RDDYVLSTKVGRIML 83
Cdd:cd19082 1 SRIVLGTADFGTR---IDEEEAFALLDAFVELGGNFIDTARVYGDwverGASERVIGEWLKSRGnRDKVVIATKGGHPDL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 84 DEMEDPtkrdfgekdgifehglknkilnDYSEDATLRSIEDSLKRLKTDRIDIVWIH--DPSQDFygDSWLEhfntartg 161
Cdd:cd19082 78 EDMSRS----------------------RLSPEDIRADLEESLERLGTDYIDLYFLHrdDPSVPV--GEIVD-------- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 162 afrALTRLREEGVIKAWGL---GVNRVE------------------PCeltLGLDEPKPDAFllaGRYSLLDHSRALQRL 220
Cdd:cd19082 126 ---TLNELVRAGKIRAFGAsnwSTERIAeanayakahglpgfaassPQ---WSLARPNEPPW---PGPTLVAMDEEMRAW 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 221 mpeALEHNVDIVvggPYSS-------GVLVGGEHFEYQKA----SPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANP-A 288
Cdd:cd19082 197 ---HEENQLPVF---AYSSqargffsKRAAGGAEDDSELRrvyySEENFERLERAKELAEEKGVSPTQIALAYVLNQPfP 270
|
330 340
....*....|....*....|.
gi 1778084114 289 VAAVIpGSSRPGRMADDLAAL 309
Cdd:cd19082 271 TVPII-GPRTPEQLRDSLAAA 290
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
15-190 |
1.30e-16 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 78.91 E-value: 1.30e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 15 GAPLGNMFR--AIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYSRDDYVLSTKVGRIMLDEmedptkr 92
Cdd:cd19103 17 GGAGGDQVFgnHLDEDTLKAVFDKAMAAGLNLWDTAAVYGMGASEKILGEFLKRYPREDYIISTKFTPQIAGQ------- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 93 dfgekdgifehglknkilndySEDATLRSIEDSLKRLKTDRIDIVWIHDPSqDFygDSWLEHfntartgafraLTRLREE 172
Cdd:cd19103 90 ---------------------SADPVADMLEGSLARLGTDYIDIYWIHNPA-DV--ERWTPE-----------LIPLLKS 134
|
170
....*....|....*...
gi 1778084114 173 GVIKAWGLGVNRVEPCEL 190
Cdd:cd19103 135 GKVKHVGVSNHNLAEIKR 152
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
28-309 |
1.63e-16 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 78.84 E-value: 1.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 28 DEALAVVHEAWNLGIRYFDTAPLYGS--GLSEIRMGEALSQ---YSRDDYVLSTKVGrimldemedptkrdFGEKDGIFE 102
Cdd:cd19089 29 EEARELLRTAFDLGITHFDLANNYGPppGSAEENFGRILKRdlrPYRDELVISTKAG--------------YGMWPGPYG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 103 HGLKNKILndysedatLRSIEDSLKRLKTDRIDIVWIH--DPSQDfygdswLEHFNTARTGAFRAltrlreeGviKAWGL 180
Cdd:cd19089 95 DGGSRKYL--------LASLDQSLKRMGLDYVDIFYHHryDPDTP------LEETMTALADAVRS-------G--KALYV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 181 GVNRVEPCELTLG---LDEPKPDAFLLAGRYSLLDHSrALQRLMPEALEHNVDIVVGGPYSSGVLVG------------- 244
Cdd:cd19089 152 GISNYPGAKARRAialLRELGVPLIIHQPRYSLLDRW-AEDGLLEVLEEAGIGFIAFSPLAQGLLTDkylngippdsrra 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1778084114 245 --GEHFEYQKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDLAAL 309
Cdd:cd19089 231 aeSKFLTEEALTPEKLEQLRKLNKIAAKRGQSLAQLALSWVLRDPRVTSVLIGASSPSQLEDNVAAL 297
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
27-316 |
3.06e-16 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 77.23 E-value: 3.06e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 27 DDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYSRDDYVLSTKVGrimldemedPTkrdfgekdgifehglk 106
Cdd:cd19137 25 DEEMVELLKTAIELGYTHIDTAEMYGGGHTEELVGKAIKDFPREDLFIVTKVW---------PT---------------- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 107 nkilnDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSQdfygdswlehfNTARTGAFRALTRLREEGVIKAwgLGVNRVE 186
Cdd:cd19137 80 -----NLRYDDLLRSLQNSLRRLDTDYIDLYLIHWPNP-----------NIPLEETLSAMAEGVRQGLIRY--IGVSNFN 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 187 PCELTLGLDEPKPDAFLLAGRYSLLDHSRALQRLMPEALEHNVDIVVGGPYSSGVLVGGEHFEyqkaspaihqqvakiyQ 266
Cdd:cd19137 142 RRLLEEAISKSQTPIVCNQVKYNLEDRDPERDGLLEYCQKNGITVVAYSPLRRGLEKTNRTLE----------------E 205
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1778084114 267 IAQQFNVDVKAAALQFSLANPAVAAvIPGSSRPGRMADDLAALATKIPAE 316
Cdd:cd19137 206 IAKNYGKTIAQIALAWLIQKPNVVA-IPKAGRVEHLKENLKATEIKLSEE 254
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
39-316 |
1.18e-15 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 75.75 E-value: 1.18e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 39 NLGIRYFDTAPLYGSGLSEIRMGEALSQySRDDYVLSTKVGrimldemedPTkrdfgekdgifehglknkilnDYSEDAT 118
Cdd:cd19138 40 DLGMTLIDTAEMYGDGGSEELVGEAIRG-RRDKVFLVSKVL---------PS---------------------NASRQGT 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 119 LRSIEDSLKRLKTDRIDIVWIHdpsqdfygdsWLEHFNTARTgaFRALTRLREEGVIKAWG---LGVNRVEPCELTLGLD 195
Cdd:cd19138 89 VRACERSLRRLGTDYLDLYLLH----------WRGGVPLAET--VAAMEELKKEGKIRAWGvsnFDTDDMEELWAVPGGG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 196 EPKPDAFLlagrYSLldHSRALQ-RLMPEALEHNVDIVVGGPYSSGVLVGGEHFEyqkaSPAIHqqvakiyQIAQQFNVD 274
Cdd:cd19138 157 NCAANQVL----YNL--GSRGIEyDLLPWCREHGVPVMAYSPLAQGGLLRRGLLE----NPTLK-------EIAARHGAT 219
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1778084114 275 VKAAALQFSLANPAVAAvIPGSSRPGRMADDLAALATKIPAE 316
Cdd:cd19138 220 PAQVALAWVLRDGNVIA-IPKSGSPEHARENAAAADLELTEE 260
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
9-334 |
2.08e-15 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 75.94 E-value: 2.08e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGNMFRAI-PDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYSRDDYVLSTKVGRIMLDEme 87
Cdd:cd19144 14 PALGFGAMGLSAFYGPPkPDEERFAVLDAAFELGCTFWDTADIYGDSEELIGRWFKQNPGKREKIFLATKFGIEKNVE-- 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 88 dptkrdfgekDGIFEhglknkilNDYSEDATLRSIEDSLKRLKTDRIDIVWIH--DPSqdfygdswlehfnTARTGAFRA 165
Cdd:cd19144 92 ----------TGEYS--------VDGSPEYVKKACETSLKRLGVDYIDLYYQHrvDGK-------------TPIEKTVAA 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 166 LTRLREEGVIKAWGL------GVNR---VEPCeltlgldepkpDAFLLagRYS--LLDHSRALQRLMPEALEHNVDIVVG 234
Cdd:cd19144 141 MAELVQEGKIKHIGLsecsaeTLRRahaVHPI-----------AAVQI--EYSpfSLDIERPEIGVLDTCRELGVAIVAY 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 235 GPYSSGVLVGG----EHFE----------YQKAS-PAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRP 299
Cdd:cd19144 208 SPLGRGFLTGAirspDDFEegdfrrmaprFQAENfPKNLELVDKIKAIAKKKNVTAGQLTLAWLLAQGDDIIPIPGTTKL 287
|
330 340 350
....*....|....*....|....*....|....*
gi 1778084114 300 GRMADDLAALATKIPAEFWLEMQRqglIAANAPLP 334
Cdd:cd19144 288 KRLEENLGALKVKLTEEEEKEIRE---IAEEAEVV 319
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
1-323 |
3.79e-14 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 71.14 E-value: 3.79e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 1 MSIKKLLPSQIGFGGAPLgnmfraiPDDEALAVVHEAWNLGIRYFDTAPLYGsglSEIRMGEAL--SQYSRDDYVLSTKV 78
Cdd:cd19140 1 VTVNGVRIPALGLGTYPL-------TGEECTRAVEHALELGYRHIDTAQMYG---NEAQVGEAIaaSGVPRDELFLTTKV 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 79 GrimldemedptkrdfgekdgifehglknkiLNDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSQDfygdswlehFNTA 158
Cdd:cd19140 71 W------------------------------PDNYSPDDFLASVEESLRKLRTDYVDLLLLHWPNKD---------VPLA 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 159 RTgaFRALTRLREEGVIKAwgLGVNRVEPCELTLGLDEPKPDAFLLAGRYS-LLDHSRALQrlmpEALEHNVDIVVggpY 237
Cdd:cd19140 112 ET--LGALNEAQEAGLARH--IGVSNFTVALLREAVELSEAPLFTNQVEYHpYLDQRKLLD----AAREHGIALTA---Y 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 238 SSgvLVGGEHFEYqkasPAIHqqvakiyQIAQQFNVDVKAAALQFSLANPAVAAvIPGSSRPGRMADDLAALATKIPAEf 317
Cdd:cd19140 181 SP--LARGEVLKD----PVLQ-------EIGRKHGKTPAQVALRWLLQQEGVAA-IPKATNPERLEENLDIFDFTLSDE- 245
|
....*.
gi 1778084114 318 wlEMQR 323
Cdd:cd19140 246 --EMAR 249
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
10-329 |
1.63e-13 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 69.30 E-value: 1.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 10 QIGFGgaplgnMFRaIPDDEALAVVHEAWNLGIRYFDTAPLYGSglsEIRMGEALSQY--SRDDYVLSTKVgrimldeme 87
Cdd:cd19139 3 AFGLG------TFR-LKDDVVIDSVRTALELGYRHIDTAQIYDN---EAAVGQAIAESgvPRDELFITTKI--------- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 88 dptkrdfgekdgifehglknKILNdYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSQdfYGDSWLEHFntartgaFRALT 167
Cdd:cd19139 64 --------------------WIDN-LSKDKLLPSLEESLEKLRTDYVDLTLIHWPSP--NDEVPVEEY-------IGALA 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 168 RLREEGVIKAwgLGVNRVEPCELTLGLDEPKPDAF---------LLAGRySLLDHSRalqrlmpealEHNVDIVVGGPYS 238
Cdd:cd19139 114 EAKEQGLTRH--IGVSNFTIALLDEAIAVVGAGAIatnqielspYLQNR-KLVAHCK----------QHGIHVTSYMTLA 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 239 SGVLVGGEhfeyqkaspaihqqvaKIYQIAQQFNVDVKAAALQFSLANPavAAVIPGSSRPGRMADDLAALATKIPAEfw 318
Cdd:cd19139 181 YGKVLDDP----------------VLAAIAERHGATPAQIALAWAMARG--YAVIPSSTKREHLRSNLLALDLTLDAD-- 240
|
330
....*....|.
gi 1778084114 319 lEMQRqglIAA 329
Cdd:cd19139 241 -DMAA---IAA 247
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
10-180 |
7.40e-13 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 67.97 E-value: 7.40e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 10 QIGFGGAPLGNMFRAIPDD---EALAVVHEAwnlGIRYFDTAPLYGSGLSEIRMGEALSQYSRddYVLSTKVgrimldem 86
Cdd:cd19075 2 KIILGTMTFGSQGRFTTAEaaaELLDAFLER---GHTEIDTARVYPDGTSEELLGELGLGERG--FKIDTKA-------- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 87 edptkrdfgekdgifeHGLKNKILndySEDATLRSIEDSLKRLKTDRIDIVWIH--DPSQDFygDSWLEHFNTartgafr 164
Cdd:cd19075 69 ----------------NPGVGGGL---SPENVRKQLETSLKRLKVDKVDVFYLHapDRSTPL--EETLAAIDE------- 120
|
170
....*....|....*.
gi 1778084114 165 altrLREEGVIKAWGL 180
Cdd:cd19075 121 ----LYKEGKFKEFGL 132
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
27-179 |
1.16e-12 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 66.53 E-value: 1.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 27 DDEALAVVHEAWNLGIRYFDTAPLYGSglsEIRMGEAL--SQYSRDDYVLSTKVGRImldemedptkrdfgekdgifehG 104
Cdd:cd19073 13 GDDCANAVKEALELGYRHIDTAEIYNN---EAEVGEAIaeSGVPREDLFITTKVWRD----------------------H 67
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1778084114 105 LKNKILndysedatLRSIEDSLKRLKTDRIDIVWIHDPSQDfygdswlehFNTARTgaFRALTRLREEGVIKAWG 179
Cdd:cd19073 68 LRPEDL--------KKSVDRSLEKLGTDYVDLLLIHWPNPT---------VPLEET--LGALKELKEAGKVKSIG 123
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
23-316 |
1.22e-12 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 67.23 E-value: 1.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 23 RAIPDDEALAVVHEAWNLGIRYFDTAPLYGSglSEIRMGEALSQY-----SRDDYVLSTK-VGRimlDEMEDPTKRDfge 96
Cdd:cd19101 18 GIRDEDAAVRAMAAYVDAGLTTFDCADIYGP--AEELIGEFRKRLrrerdAADDVQIHTKwVPD---PGELTMTRAY--- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 97 kdgifehglknkilndysedaTLRSIEDSLKRLKTDRIDIVWIH--DPSQDFYGDswlehfntartgAFRALTRLREEGV 174
Cdd:cd19101 90 ---------------------VEAAIDRSLKRLGVDRLDLVQFHwwDYSDPGYLD------------AAKHLAELQEEGK 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 175 IKawglgvnrvepcelTLGL---DEPKPDAFLLAG--------RYSLLDHsRALQRLMPEALEHNVDIVvggPYssGVLV 243
Cdd:cd19101 137 IR--------------HLGLtnfDTERLREILDAGvpivsnqvQYSLLDR-RPENGMAALCEDHGIKLL---AY--GTLA 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 244 GG-----------------EHFEYQKASPAIH--------QQV-AKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSS 297
Cdd:cd19101 197 GGllsekylgvpeptgpalETRSLQKYKLMIDewggwdlfQELlRTLKAIADKHGVSIANVAVRWVLDQPGVAGVIVGAR 276
|
330
....*....|....*....
gi 1778084114 298 RPGRMADDLAALATKIPAE 316
Cdd:cd19101 277 NSEHIDDNVRAFSFRLDDE 295
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
10-180 |
2.12e-12 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 66.06 E-value: 2.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 10 QIGFGgaplgnMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSglsEIRMGEAL--SQYSRDDYVLSTKVGrimldeme 87
Cdd:cd19133 11 ILGFG------VFQIPDPEECERAVLEAIKAGYRLIDTAAAYGN---EEAVGRAIkkSGIPREELFITTKLW-------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 88 dptkrdfgekdgifehglknkiLNDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSQDFYgdswlehfntartGAFRALT 167
Cdd:cd19133 74 ----------------------IQDAGYEKAKKAFERSLKRLGLDYLDLYLIHQPFGDVY-------------GAWRAME 118
|
170
....*....|...
gi 1778084114 168 RLREEGVIKAWGL 180
Cdd:cd19133 119 ELYKEGKIRAIGV 131
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
10-179 |
2.82e-12 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 65.88 E-value: 2.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 10 QIGFGgaplgnMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSglsEIRMGEAL--SQYSRDDYVLSTKVGRimldeme 87
Cdd:cd19157 12 WLGLG------VFKVEEGSEVVNAVKTALKNGYRSIDTAAIYGN---EEGVGKGIkeSGIPREELFITSKVWN------- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 88 dptkrdfgekdgifehglknkilNDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSQDFYGDSWlehfntartgafRALT 167
Cdd:cd19157 76 -----------------------ADQGYDSTLKAFEASLERLGLDYLDLYLIHWPVKGKYKETW------------KALE 120
|
170
....*....|..
gi 1778084114 168 RLREEGVIKAWG 179
Cdd:cd19157 121 KLYKDGRVRAIG 132
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
9-180 |
5.90e-12 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 65.53 E-value: 5.90e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGNMFRA-IPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQYSRDDYVLSTKVGrimldeme 87
Cdd:cd19145 13 SAQGLGCMGLSGDYGApKPEEEGIALIHHAFNSGVTFLDTSDIYGPNTNEVLLGKALKDGPREKVQLATKFG-------- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 88 dptkrdFGEKDGifeHGLKNKILNDYSEDATlrsiEDSLKRLKTDRIDIVWIHD-----PSQDFYGdswlehfntartga 162
Cdd:cd19145 85 ------IHEIGG---SGVEVRGDPAYVRAAC----EASLKRLDVDYIDLYYQHRidttvPIEITMG-------------- 137
|
170
....*....|....*...
gi 1778084114 163 frALTRLREEGVIKAWGL 180
Cdd:cd19145 138 --ELKKLVEEGKIKYIGL 153
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
9-142 |
2.82e-11 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 63.64 E-value: 2.82e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPlgNMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQ--YSRDDYVLSTKVgrimldem 86
Cdd:cd19142 14 SNVGLGTWS--TFSTAISEEQAEEIVTLAYENGINYFDTSDAFTSGQAETELGRILKKkgWKRSSYIVSTKI-------- 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1778084114 87 edptKRDFGEKDGifehGLKNKILndysedatLRSIEDSLKRLKTDRIDIVWIH--DP 142
Cdd:cd19142 84 ----YWSYGSEER----GLSRKHI--------IESVRASLRRLQLDYIDIVIIHkaDP 125
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
10-316 |
4.31e-11 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 62.63 E-value: 4.31e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 10 QIGFG-GAPLGNMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGsglSEIRMGEALSQY--SRDDYVLSTKVGRIMLDEM 86
Cdd:cd19120 6 AIAFGtGTAWYKSGDDDIQRDLVDSVKLALKAGFRHIDTAEMYG---NEKEVGEALKESgvPREDLFITTKVSPGIKDPR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 87 EdptkrdfgekdgifehglknkilndysedatlrSIEDSLKRLKTDRIDIVWIHDPSqdFYGDSWLEHfntarTGAFRAL 166
Cdd:cd19120 83 E---------------------------------ALRKSLAKLGVDYVDLYLIHSPF--FAKEGGPTL-----AEAWAEL 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 167 TRLREEGVIKAWGLGVNRVEPCELTLGLDEPKP-------DAFLLAGRYSLLDHSRalqrlmpealEHNvdIVVG--GPY 237
Cdd:cd19120 123 EALKDAGLVRSIGVSNFRIEDLEELLDTAKIKPavnqiefHPYLYPQQPALLEYCR----------EHG--IVVSaySPL 190
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1778084114 238 SSGVLVGGEHFEyqkaspaihqqvAKIYQIAQQFNVDVKAAALQFSLANPAVaaVIPGSSRPGRMADDLAALATKIPAE 316
Cdd:cd19120 191 SPLTRDAGGPLD------------PVLEKIAEKYGVTPAQVLLRWALQKGIV--VVTTSSKEERMKEYLEAFDFELTEE 255
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
11-187 |
5.17e-11 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 61.90 E-value: 5.17e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 11 IGFGGAPLGnmfraipDDEALAVVHEAWNLGIRYFDTAPLYGSglsEIRMGEAL--SQYSRDDYVLSTKV-GRimldeme 87
Cdd:cd19132 10 IGFGTYPLK-------GDEGVEAVVAALQAGYRLLDTAFNYEN---EGAVGEAVrrSGVPREELFVTTKLpGR------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 88 dptkrdfgekdgifEHGlknkilndysEDATLRSIEDSLKRLKTDRIDIVWIH--DPSQDFYGDSWlehfntartgafRA 165
Cdd:cd19132 73 --------------HHG----------YEEALRTIEESLYRLGLDYVDLYLIHwpNPSRDLYVEAW------------QA 116
|
170 180
....*....|....*....|..
gi 1778084114 166 LTRLREEGVIKAwgLGVNRVEP 187
Cdd:cd19132 117 LIEAREEGLVRS--IGVSNFLP 136
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
27-179 |
2.09e-10 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 60.47 E-value: 2.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 27 DDEALAVVHEAWNLGIRYFDTAPLYGsglSEIRMGEALSQYS--RDDYVLSTkvgrimldemedptkrdfgekdgifehg 104
Cdd:PRK11565 27 NEEVITAIHKALEVGYRSIDTAAIYK---NEEGVGKALKEASvaREELFITT---------------------------- 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1778084114 105 lknKILNDYSEDATlRSIEDSLKRLKTDRIDIVWIH--DPSQDFYGDSWlehfntartgafRALTRLREEGVIKAWG 179
Cdd:PRK11565 76 ---KLWNDDHKRPR-EALEESLKKLQLDYVDLYLMHwpVPAIDHYVEAW------------KGMIELQKEGLIKSIG 136
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
10-179 |
4.51e-10 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 59.34 E-value: 4.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 10 QIGFGgaplgnMFrAIPDDEALAVVHEAWNLGIRYFDTAPLYGSglsEIRMGEAL--SQYSRDDYVLSTKVgrimldeme 87
Cdd:cd19127 11 ALGLG------VF-QTPPEETADAVATALADGYRLIDTAAAYGN---EREVGEGIrrSGVDRSDIFVTTKL--------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 88 dptkrdfgekdgifehglknkILNDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSQDFYGDSwlehfntarTGAFRALT 167
Cdd:cd19127 72 ---------------------WISDYGYDKALRGFDASLRRLGLDYVDLYLLHWPVPNDFDRT---------IQAYKALE 121
|
170
....*....|..
gi 1778084114 168 RLREEGVIKAWG 179
Cdd:cd19127 122 KLLAEGRVRAIG 133
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
10-307 |
4.95e-10 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 59.15 E-value: 4.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 10 QIGFGgaplgnMFRaIPDDEALAVVHEAWNLGIRYFDTAPLYGsglSEIRMGEAL--SQYSRDDYVLSTKVGRimldeme 87
Cdd:cd19130 12 QLGYG------VFK-VPPADTQRAVATALEVGYRHIDTAAIYG---NEEGVGAAIaaSGIPRDELFVTTKLWN------- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 88 dptkrdfgekdgifehglknkilNDYSEDATLRSIEDSLKRLKTDRIDIVWIH--DPSQDFYGDSWlehfntartgafRA 165
Cdd:cd19130 75 -----------------------DRHDGDEPAAAFAESLAKLGLDQVDLYLVHwpTPAAGNYVHTW------------EA 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 166 LTRLREEGVIKAWGLGVNRVEPCELTLGLDEPKPdaflLAGRYSLldHSRALQRLMPEALE-HNVDIVVGGPYSSGVLVG 244
Cdd:cd19130 120 MIELRAAGRTRSIGVSNFLPPHLERIVAATGVVP----AVNQIEL--HPAYQQRTIRDWAQaHDVKIEAWSPLGQGKLLG 193
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1778084114 245 GEhfeyqkaspaihqqvaKIYQIAQQFNVDVKAAALQFSLANPAVaaVIPGSSRPGRMADDLA 307
Cdd:cd19130 194 DP----------------PVGAIAAAHGKTPAQIVLRWHLQKGHV--VFPKSVRRERMEDNLD 238
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
32-309 |
5.52e-10 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 59.72 E-value: 5.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 32 AVVHEAWNLGIRYFDTAPLYG--SGLSEIRMGEALS---QYSRDDYVLSTKVGRIMLDemeDPTKrDFGEKdgifehglk 106
Cdd:cd19151 34 AMLRRAFDLGITHFDLANNYGppPGSAEENFGRILKedlKPYRDELIISTKAGYTMWP---GPYG-DWGSK--------- 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 107 nKILndysedatLRSIEDSLKRLKTDRIDIVWIHDPSQDfygdswlehfnTARTGAFRALTRLREEGviKAWGLGVNRVE 186
Cdd:cd19151 101 -KYL--------IASLDQSLKRMGLDYVDIFYHHRPDPE-----------TPLEETMGALDQIVRQG--KALYVGISNYP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 187 PCELTLG---LDEPKPDAFLLAGRYSLLDhsRALQRLMPEALEHN-VDIVVGGPYSSGVLV---------------GGEH 247
Cdd:cd19151 159 PEEAREAaaiLKDLGTPCLIHQPKYSMFN--RWVEEGLLDVLEEEgIGCIAFSPLAQGLLTdrylngipedsraakGSSF 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1778084114 248 FEYQKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDLAAL 309
Cdd:cd19151 237 LKPEQITEEKLAKVRRLNEIAQARGQKLAQMALAWVLRNKRVTSVLIGASKPSQIEDAVGAL 298
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
9-316 |
6.45e-10 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 59.17 E-value: 6.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLGNMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIR---MGEALSQY--SRDDYVLSTKVGriml 83
Cdd:cd19077 6 GPIGLGLMGLTWRPNPTPDEEAFETMKAALDAGSNLWNGGEFYGPPDPHANlklLARFFRKYpeYADKVVLSVKGG---- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 84 demedpTKRDFGEKDGifehglknkilndySEDATLRSIEDSLKRLK-TDRIDIvwihdpsqdfygdswlehFNTARTG- 161
Cdd:cd19077 82 ------LDPDTLRPDG--------------SPEAVRKSIENILRALGgTKKIDI------------------FEPARVDp 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 162 ------AFRALTRLREEGVIKAWGLG---------VNRVEP-----CELTLG-LDEPKPDAF------------------ 202
Cdd:cd19077 124 nvpieeTIKALKELVKEGKIRGIGLSevsaetirrAHAVHPiaaveVEYSLFsREIEENGVLetcaelgipiiaysplgr 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 203 -LLAGRYSLL------DHSRALQRLMPEALEHNVDIvvggpyssgvlvggehfeyqkaspaihqqVAKIYQIAQQFNVDV 275
Cdd:cd19077 204 gLLTGRIKSLadipegDFRRHLDRFNGENFEKNLKL-----------------------------VDALQELAEKKGCTP 254
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1778084114 276 KAAALQFSLANPAVAAV-IPGSSRPGRMADDLAALATKIPAE 316
Cdd:cd19077 255 AQLALAWILAQSGPKIIpIPGSTTLERVEENLKAANVELTDE 296
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
32-190 |
3.75e-09 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 56.56 E-value: 3.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 32 AVVHEAWNLGIRYFDTAPLYGSglsEIRMGEAL--SQYSRDDYVLSTKVGrimldemedPTkrdfgekdgifehglknki 109
Cdd:cd19135 30 AVVYALKECGYRHIDTAKRYGC---EELLGKAIkeSGVPREDLFLTTKLW---------PS------------------- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 110 lnDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPsqdfYGDSWLEHFNTARTGAFRALTRLREEGVIKAwgLGVNRVEPCE 189
Cdd:cd19135 79 --DYGYESTKQAFEASLKRLGVDYLDLYLLHWP----DCPSSGKNVKETRAETWRALEELYDEGLCRA--IGVSNFLIEH 150
|
.
gi 1778084114 190 L 190
Cdd:cd19135 151 L 151
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
9-310 |
5.24e-09 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 56.69 E-value: 5.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGG-APLGNMfraIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEAL--SQYSRDDYVLSTKV---GRim 82
Cdd:cd19141 13 SCLGLGTwVTFGSQ---ISDEVAEELVTLAYENGINLFDTAEVYAAGKAEIVLGKILkkKGWRRSSYVITTKIfwgGK-- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 83 ldemedptkrdfGEKdgifEHGLKNKILndysedatLRSIEDSLKRLKTDRIDIVWIHDPsqdfygDSwlehfNTARTGA 162
Cdd:cd19141 88 ------------AET----ERGLSRKHI--------IEGLKASLERLQLEYVDIVFANRP------DP-----NTPMEEI 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 163 FRALTRLREEGVIKAWGlgVNRVEPCELTlgldepkpDAFLLAGRYSL-----------LDHSRALQRLMPEaLEHNVDI 231
Cdd:cd19141 133 VRAFTHVINQGMAMYWG--TSRWSAMEIM--------EAYSVARQFNLippiveqaeyhLFQREKVEMQLPE-LFHKIGV 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 232 --VVGGPYSSGVLVGgehfEYQKASPAIHQQVAKIYQ-----------------------IAQQFNVDVKAAALQFSLAN 286
Cdd:cd19141 202 gaMTWSPLACGILSG----KYDDGVPEYSRASLKGYQwlkekilseegrrqqaklkelqiIADRLGCTLPQLAIAWCLKN 277
|
330 340
....*....|....*....|....
gi 1778084114 287 PAVAAVIPGSSRPGRMADDLAALA 310
Cdd:cd19141 278 EGVSSVLLGASSTEQLYENLQAIQ 301
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
11-191 |
5.44e-09 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 56.10 E-value: 5.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 11 IGFGgaplgnMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGsglSEIRMGEALSQY------SRDDYVLSTKVGRimld 84
Cdd:cd19136 4 LGLG------TFRLRGEEEVRQAVDAALKAGYRLIDTASVYR---NEADIGKALRDLlpkyglSREDIFITSKLAP---- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 85 emedptkrdfgekdgifehglknkilNDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPsqdfyGDSWLEHFNTA----RT 160
Cdd:cd19136 71 --------------------------KDQGYEKARAACLGSLERLGTDYLDLYLIHWP-----GVQGLKPSDPRnaelRR 119
|
170 180 190
....*....|....*....|....*....|.
gi 1778084114 161 GAFRALTRLREEGVIKAwgLGVNRVEPCELT 191
Cdd:cd19136 120 ESWRALEDLYKEGKLRA--IGVSNYTVRHLE 148
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
7-309 |
9.05e-09 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 55.82 E-value: 9.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 7 LPSQIGFGGAplgnmfraIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQ--YSRDDYVLSTKVGrimld 84
Cdd:cd19159 18 LGTWVTFGGQ--------ISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKkgWRRSSLVITTKLY----- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 85 emedptkrdFGEKDGIfEHGLKNKILndysedatLRSIEDSLKRLKTDRIDIVWIHDPSQdfygdswlehfNTARTGAFR 164
Cdd:cd19159 85 ---------WGGKAET-ERGLSRKHI--------IEGLKGSLQRLQLEYVDVVFANRPDS-----------NTPMEEIVR 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 165 ALTRLREEGVIKAWGlgVNRVEPCELTlgldepkpDAFLLAGRYSL-----------LDHSRALQRLMPEaLEHNVDI-- 231
Cdd:cd19159 136 AMTHVINQGMAMYWG--TSRWSAMEIM--------EAYSVARQFNMippvceqaeyhLFQREKVEVQLPE-LYHKIGVga 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 232 VVGGPYSSGVLVGgehfEYQKASPAIHQQVAKIYQ-----------------------IAQQFNVDVKAAALQFSLANPA 288
Cdd:cd19159 205 MTWSPLACGIISG----KYGNGVPESSRASLKCYQwlkerivseegrkqqnklkdlspIAERLGCTLPQLAVAWCLRNEG 280
|
330 340
....*....|....*....|.
gi 1778084114 289 VAAVIPGSSRPGRMADDLAAL 309
Cdd:cd19159 281 VSSVLLGSSTPEQLIENLGAI 301
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
10-179 |
1.01e-08 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 55.14 E-value: 1.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 10 QIGFGgaplgnMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSglsEIRMGEAL--SQYSRDDYVLSTKVGRimldeme 87
Cdd:cd19126 11 WLGLG------VFQTPDGDETERAVQTALENGYRSIDTAAIYKN---EEGVGEAIreSGVPREELFVTTKLWN------- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 88 dptkrdfgekdgifehglknkilNDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSQDFYGDSWlehfntartgafRALT 167
Cdd:cd19126 75 -----------------------DDQRARRTEDAFQESLDRLGLDYVDLYLIHWPGKDKFIDTW------------KALE 119
|
170
....*....|..
gi 1778084114 168 RLREEGVIKAWG 179
Cdd:cd19126 120 KLYASGKVKAIG 131
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
41-309 |
2.04e-08 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 54.65 E-value: 2.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 41 GIRYFDTAPLYGS-------GLSEIRMGEALSQYS-RDDYVLSTKVGRIMLDEMEDPTKRDfgekdgifehGLknkilnd 112
Cdd:cd19752 30 GGNFLDTANNYAFwteggvgGESERLIGRWLKDRGnRDDVVIATKVGAGPRDPDGGPESPE----------GL------- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 113 ySEDATLRSIEDSLKRLKTDRIDIVWIHdpsqdfygdswLEHFNTARTGAFRALTRLREEGVI--------KAWGLGVNR 184
Cdd:cd19752 93 -SAETIEQEIDKSLRRLGTDYIDLYYAH-----------VDDRDTPLEETLEAFNELVKAGKVraigasnfAAWRLERAR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 185 --------VEPCELTL--GLDEPKPDAfllagrySLLDHSRALQRLMPEALEHNVDIVVggPYSSgvLVGGEH------F 248
Cdd:cd19752 161 qiarqqgwAEFSAIQQrhSYLRPRPGA-------DFGVQRIVTDELLDYASSRPDLTLL--AYSP--LLSGAYtrpdrpL 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1778084114 249 EYQKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPavAAVIP--GSSRPGRMADDLAAL 309
Cdd:cd19752 230 PEQYDGPDSDARLAVLEEVAGELGATPNQVVLAWLLHRT--PAIIPllGASTVEQLEENLAAL 290
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
11-180 |
2.30e-08 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 54.60 E-value: 2.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 11 IGFGgaplgnMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGsglSEIRMGEALS------QYSRDDYVLSTKVGrimld 84
Cdd:cd19116 14 IALG------TWKLKDDEGVRQAVKHAIEAGYRHIDTAYLYG---NEAEVGEAIRekiaegVVKREDLFITTKLW----- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 85 emedptkrdfgekdgifehglknkilNDYSE-DATLRSIEDSLKRLKTDRIDIVWIHDP-----SQDFYGDSWLEHFNTA 158
Cdd:cd19116 80 --------------------------NSYHErEQVEPALRESLKRLGLDYVDLYLIHWPvafkeNNDSESNGDGSLSDID 133
|
170 180
....*....|....*....|..
gi 1778084114 159 RTGAFRALTRLREEGVIKAWGL 180
Cdd:cd19116 134 YLETWRGMEDLVKLGLTRSIGV 155
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
25-309 |
5.23e-08 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 53.84 E-value: 5.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 25 IPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQ--YSRDDYVLSTKVgrimldemedptkrdFGEKDGIFE 102
Cdd:cd19160 30 ISDETAEDLLTVAYEHGVNLFDTAEVYAAGKAERTLGNILKSkgWRRSSYVVTTKI---------------YWGGQAETE 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 103 HGLKNKILndysedatLRSIEDSLKRLKTDRIDIVWIH--DPsqdfygdswlehfNTARTGAFRALTRLREEGVIKAWgl 180
Cdd:cd19160 95 RGLSRKHI--------IEGLRGSLDRLQLEYVDIVFANrsDP-------------NSPMEEIVRAMTYVINQGMAMYW-- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 181 GVNRVEPCELTlgldepkpDAFLLAGRYSLLD------HSRALQR-----LMPEaLEHNVDI--VVGGPYSSGVLVG--- 244
Cdd:cd19160 152 GTSRWSAMEIM--------EAYSVARQFNLIPpvceqaEYHLFQRekvemQLPE-LYHKIGVgsVTWSPLACGLITGkyd 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 245 ------------GEHFEYQKA-SPAIHQQVAKIYQ---IAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDLAA 308
Cdd:cd19160 223 grvpdtcraavkGYQWLKEKVqSEEGKKQQAKVKElhpIADRLGCTVAQLAIAWCLRSEGVSSVLLGVSSAEQLIENLGS 302
|
.
gi 1778084114 309 L 309
Cdd:cd19160 303 I 303
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
7-309 |
7.65e-08 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 53.17 E-value: 7.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 7 LPSQIGFGGAplgnmfraIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQ--YSRDDYVLSTKVgrimld 84
Cdd:cd19158 18 LGTWVTFGGQ--------ITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKkgWRRSSLVITTKI------ 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 85 emedptkrdFGEKDGIFEHGLKNKILndysedatLRSIEDSLKRLKTDRIDIVWIHDPSQdfygdswlehfNTARTGAFR 164
Cdd:cd19158 84 ---------FWGGKAETERGLSRKHI--------IEGLKASLERLQLEYVDVVFANRPDP-----------NTPMEETVR 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 165 ALTRLREEGVIKAWGlgVNRVEPCELTlgldepkpDAFLLAGRYSL-----------LDHSRALQRLMPEaLEHNVDI-- 231
Cdd:cd19158 136 AMTHVINQGMAMYWG--TSRWSSMEIM--------EAYSVARQFNLippiceqaeyhMFQREKVEVQLPE-LFHKIGVga 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 232 ---------VVGGPYSSGV-------LVGGEHFEYQKASPAIHQQVAKIYQ---IAQQFNVDVKAAALQFSLANPAVAAV 292
Cdd:cd19158 205 mtwsplacgIVSGKYDSGIppysrasLKGYQWLKDKILSEEGRRQQAKLKElqaIAERLGCTLPQLAIAWCLRNEGVSSV 284
|
330
....*....|....*..
gi 1778084114 293 IPGSSRPGRMADDLAAL 309
Cdd:cd19158 285 LLGASNAEQLMENIGAI 301
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
26-309 |
2.36e-07 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 51.91 E-value: 2.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 26 PDDEALAVVHEAWNLGIRYFDTAPLYG--SGLSEIRMGEALSQ---YSRDDYVLSTKVGRIMLdemedptkrdfgekDGI 100
Cdd:PRK09912 41 ALESQRAILRKAFDLGITHFDLANNYGppPGSAEENFGRLLREdfaAYRDELIISTKAGYDMW--------------PGP 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 101 FEHGLKNKILndysedatLRSIEDSLKRLKTDRIDIVWIHDPSQdfygdswlehfNTARTGAFRALTRLREEGviKAWGL 180
Cdd:PRK09912 107 YGSGGSRKYL--------LASLDQSLKRMGLEYVDIFYSHRVDE-----------NTPMEETASALAHAVQSG--KALYV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 181 GVNRVEP---CELTLGLDEPKPDAFLLAGRYSLLDHSRALQRLMPEALEHNVDIVVGGPYSSGVLVGgehfEYQKASPA- 256
Cdd:PRK09912 166 GISSYSPertQKMVELLREWKIPLLIHQPSYNLLNRWVDKSGLLDTLQNNGVGCIAFTPLAQGLLTG----KYLNGIPQd 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1778084114 257 --IHQQVAKIY-------------------QIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDLAAL 309
Cdd:PRK09912 242 srMHREGNKVRgltpkmlteanlnslrllnEMAQQRGQSMAQMALSWLLKDERVTSVLIGASRAEQLEENVQAL 315
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
22-143 |
5.19e-07 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 50.41 E-value: 5.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 22 FRaIPDDEALAVVHEAWNLGIRYFDTAPLYGSglsEIRMGEAL--SQYSRDDYVLSTKvgrIMLDEmedptkrdfgekdg 99
Cdd:PRK11172 11 FR-LKDQVVIDSVKTALELGYRAIDTAQIYDN---EAAVGQAIaeSGVPRDELFITTK---IWIDN-------------- 69
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1778084114 100 ifehglknkilndYSEDATLRSIEDSLKRLKTDRIDIVWIHDPS 143
Cdd:PRK11172 70 -------------LAKDKLIPSLKESLQKLRTDYVDLTLIHWPS 100
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
28-180 |
5.64e-07 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 50.35 E-value: 5.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 28 DEALAVVHEAWNLGIRYFDTAPLYGSGLSE--IRmgEALSQYsRDDYVLSTKVGrimldemedpTKRDfgeKDGIFehgl 105
Cdd:PRK10376 40 DAAIAVLREAVALGVNHIDTSDFYGPHVTNqlIR--EALHPY-PDDLTIVTKVG----------ARRG---EDGSW---- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 106 knkiLNDYSEDATLRSIEDSLKRLKTDRIDIV------WIHDPSQdfygDSWLEhfntartgAFRALTRLREEGVIKAWG 179
Cdd:PRK10376 100 ----LPAFSPAELRRAVHDNLRNLGLDVLDVVnlrlmgDGHGPAE----GSIEE--------PLTVLAELQRQGLVRHIG 163
|
.
gi 1778084114 180 L 180
Cdd:PRK10376 164 L 164
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
11-142 |
1.14e-06 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 49.19 E-value: 1.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 11 IGFGGAPlgnmFRAIPDDEALAVvHEAWNLGIRYFDTAPLYGsglSEIRMGEALSQ-------YSRDDYVLSTKVgriml 83
Cdd:cd19124 8 IGMGTAS----DPPSPEDIKAAV-LEAIEVGYRHFDTAAAYG---TEEALGEALAEalrlglvKSRDELFVTSKL----- 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1778084114 84 demedptkrdfgekdgifehglknkILNDYSEDATLRSIEDSLKRLKTDRIDIVWIHDP 142
Cdd:cd19124 75 -------------------------WCSDAHPDLVLPALKKSLRNLQLEYVDLYLIHWP 108
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
8-140 |
1.49e-06 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 49.34 E-value: 1.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 8 PSQIG---FGGApLGNMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSGLSEIRMGEALSQY-SRDDYVLSTKVGRIML 83
Cdd:cd19146 13 PLCLGamsFGEA-WKSMMGECDKETAFKLLDAFYEQGGNFIDTANNYQGEESERWVGEWMASRgNRDEMVLATKYTTGYR 91
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1778084114 84 DEMEDPTKRDFGEkdgifeHGLKNKILndysedatlrSIEDSLKRLKTDRIDIVWIH 140
Cdd:cd19146 92 RGGPIKIKSNYQG------NHAKSLRL----------SVEASLKKLQTSYIDILYVH 132
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
26-180 |
2.22e-06 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 48.65 E-value: 2.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 26 PDDEALAVVHEAWNLGIRYFDTAPLYGSglsEIRMGEALSQY------SRDDYVLSTKVgrimldemedPTkrdfgekdg 99
Cdd:cd19111 15 PPEEVRAAVDYALFVGYRHIDTALSYQN---EKAIGEALKWWlkngklKREEVFITTKL----------PP--------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 100 ifeHGLKNKilndysedATLRSIEDSLKRLKTDRIDIVWIHDPS--QDFYGDSWLEHFNTARTGAFRALTRLREEGVIKA 177
Cdd:cd19111 73 ---VYLEFK--------DTEKSLEKSLENLKLPYVDLYLIHHPCgfVNKKDKGERELASSDVTSVWRAMEALVSEGKVKS 141
|
...
gi 1778084114 178 WGL 180
Cdd:cd19111 142 IGL 144
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
10-191 |
2.56e-06 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 48.28 E-value: 2.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 10 QIGFGgaplgnMFRAIPDDEALAVVHEAWNLGIRYFDTAPLYGSglsEIRMGEALSQ--YSRDDYVLSTKVGRimldeme 87
Cdd:cd19156 11 RLGLG------VWRVQDGAEAENAVKWAIEAGYRHIDTAAIYKN---EEGVGQGIREsgVPREEVFVTTKLWN------- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 88 dptkrdfgekdgifehglknkilNDYSEDATLRSIEDSLKRLKTDRIDIVWIHDPSQDFYGDSWlehfntartgafRALT 167
Cdd:cd19156 75 -----------------------SDQGYESTLAAFEESLEKLGLDYVDLYLIHWPVKGKFKDTW------------KAFE 119
|
170 180
....*....|....*....|....
gi 1778084114 168 RLREEGVIKAwgLGVNRVEPCELT 191
Cdd:cd19156 120 KLYKEKKVRA--IGVSNFHEHHLE 141
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
26-309 |
8.29e-05 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 43.60 E-value: 8.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 26 PDDEALAVVHEAWNLGIRYFDTAPLYG--SGLSEIRMGEALSQ----YsRDDYVLSTKVGRIMLdemedptkrdfgekDG 99
Cdd:cd19150 28 PLETQRAILRTAFDLGITHFDLANNYGppPGSAEENFGRILREdfagY-RDELIISTKAGYDMW--------------PG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 100 IFEHGLKNKILndysedatLRSIEDSLKRLKTDRIDIVWIH--DPsqdfygDSWLEHFNTARTGAFR---AL-------- 166
Cdd:cd19150 93 PYGEWGSRKYL--------LASLDQSLKRMGLDYVDIFYSHrfDP------DTPLEETMGALDHAVRsgkALyvgissys 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 167 -TRLREEGVI-KAWGLgvnrvePCEltlgLDEPKpdafllagrYSLLDHSRALQRLMPEALEHNVDIVVGGPYSSGVLVG 244
Cdd:cd19150 159 pERTREAAAIlRELGT------PLL----IHQPS---------YNMLNRWVEESGLLDTLQELGVGCIAFTPLAQGLLTD 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1778084114 245 --------------GEHFEYQKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGSSRPGRMADDLAAL 309
Cdd:cd19150 220 kylngipegsraskERSLSPKMLTEANLNSIRALNEIAQKRGQSLAQMALAWVLRDGRVTSALIGASRPEQLEENVGAL 298
|
|
| AKR_unchar |
cd19098 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
9-316 |
1.47e-03 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381324 [Multi-domain] Cd Length: 318 Bit Score: 40.02 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 9 SQIGFGGAPLG-----NMFRA--IPDD---EAL-----AVVHEAWNLGIRYFDTAPLYgsGLSEIRMGEALSQ--YSRDD 71
Cdd:cd19098 1 PRLGLGLAALGrpgyiNLGHAadLGSGrsvEAMrahthAVLDAAWAAGVRYFDAARSY--GRAEEFLGSWLRSrnIAPDA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 72 YVLSTKVGRIMLDEMEDPTKRdfgekdgifeHGLKnkilnDYSEDATLRSIEDSLKRLKtDRIDIVWIHDPsqdfygdsw 151
Cdd:cd19098 79 VFVGSKWGYTYTADWQVDAAV----------HEVK-----DHSLARLLKQWEETRSLLG-KHLDLYQIHSA--------- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 152 lehfnTARTGAFR------ALTRLREEGVikAWGLGVNRVEPCE-----LTLGLDEPKPDAFLLAgRYSLLDHSRAlqrl 220
Cdd:cd19098 134 -----TLESGVLEdadvlaALAELKAEGV--KIGLSLSGPQQAEtlrraLEIEIDGARLFDSVQA-TWNLLEQSAG---- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1778084114 221 mpEALE--HNV--DIVVGGPYSSGVLVGGehfeyqKASPAIHQQVAKIYQIAQQFNVDVKAAALQFSLANPAVAAVIPGS 296
Cdd:cd19098 202 --EALEeaHEAgmGVIVKEALANGRLTDR------NPSPELAPLMAVLKAVADRLGVTPDALALAAVLAQPFVDVVLSGA 273
|
330 340
....*....|....*....|
gi 1778084114 297 SRPGRMADDLAALATKIPAE 316
Cdd:cd19098 274 ATPEQLRSNLRALDVSLDLE 293
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