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Conserved domains on  [gi|1783231644|ref|WP_156302203|]
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winged helix-turn-helix transcriptional regulator [Lacticaseibacillus pantheris]

Protein Classification

winged helix-turn-helix transcriptional regulator( domain architecture ID 10004391)

winged helix-turn-helix (HTH) transcriptional regulator containing a HxlR family HTH domain; similar to HTH-type transcriptional regulator HxlR, a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10679470|10908318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
10-117 1.40e-33

DNA-binding transcriptional regulator, HxlR family [Transcription];


:

Pssm-ID: 441339  Cd Length: 108  Bit Score: 112.65  E-value: 1.40e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783231644  10 TQDKTSKDLCPhFQKTFSILGKKWNGLILEVLIDGPHRFKDIAGSIPKCSDRVLVERLKELEGEGIVDRVTHPNSSL-IE 88
Cdd:COG1733     1 KKKDLKEADCP-VRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPrVE 79

                          90       100
                  ....*....|....*....|....*....
gi 1783231644  89 YQLTDKGQGLNQVLTAAHAWGDEWLTDEE 117
Cdd:COG1733    80 YSLTEKGRSLLPVLDALAEWGEEHLPEIE 108
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
10-117 1.40e-33

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 112.65  E-value: 1.40e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783231644  10 TQDKTSKDLCPhFQKTFSILGKKWNGLILEVLIDGPHRFKDIAGSIPKCSDRVLVERLKELEGEGIVDRVTHPNSSL-IE 88
Cdd:COG1733     1 KKKDLKEADCP-VRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPrVE 79

                          90       100
                  ....*....|....*....|....*....
gi 1783231644  89 YQLTDKGQGLNQVLTAAHAWGDEWLTDEE 117
Cdd:COG1733    80 YSLTEKGRSLLPVLDALAEWGEEHLPEIE 108
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 28-113 7.56e-30

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 102.77  E-value: 7.56e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783231644  28 ILGKKWNGLILEVLIDGPHRFKDIAGSIPKCSDRVLVERLKELEGEGIVDRVTHPNSSL-IEYQLTDKGQGLNQVLTAAH 106
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPkVEYSLTEKGRSLEPILQELC 80


                  ....*..
gi 1783231644 107 AWGDEWL 113
Cdd:pfam01638  81 DWGEEYL 87
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 26-94 2.81e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.20  E-value: 2.81e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1783231644  26 FSILGKKWNGLILEVLIDGPHRFKDIAG----SIPKCSdrvlvERLKELEGEGIVDRVTHPNSslIEYQLTDK 94
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAErlglSQSTVS-----RHLKKLEEAGLVESRREGRR--VYYSLTDA 66
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
67-117 9.99e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 33.34  E-value: 9.99e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1783231644   67 LKELEGEGIVDRVTHPN---SSLIeyQLTDKGQGL-NQVLTAAHAWGDEW---LTDEE 117
Cdd:smart00347  45 LDRLEKKGLVRREPSPEdrrSVLV--SLTEEGRELiEQLLEARSETLAELlagLTAEE 100
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
10-117 1.40e-33

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 112.65  E-value: 1.40e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783231644  10 TQDKTSKDLCPhFQKTFSILGKKWNGLILEVLIDGPHRFKDIAGSIPKCSDRVLVERLKELEGEGIVDRVTHPNSSL-IE 88
Cdd:COG1733     1 KKKDLKEADCP-VRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPrVE 79

                          90       100
                  ....*....|....*....|....*....
gi 1783231644  89 YQLTDKGQGLNQVLTAAHAWGDEWLTDEE 117
Cdd:COG1733    80 YSLTEKGRSLLPVLDALAEWGEEHLPEIE 108
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 28-113 7.56e-30

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 102.77  E-value: 7.56e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783231644  28 ILGKKWNGLILEVLIDGPHRFKDIAGSIPKCSDRVLVERLKELEGEGIVDRVTHPNSSL-IEYQLTDKGQGLNQVLTAAH 106
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPkVEYSLTEKGRSLEPILQELC 80


                  ....*..
gi 1783231644 107 AWGDEWL 113
Cdd:pfam01638  81 DWGEEYL 87
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 26-94 2.81e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.20  E-value: 2.81e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1783231644  26 FSILGKKWNGLILEVLIDGPHRFKDIAG----SIPKCSdrvlvERLKELEGEGIVDRVTHPNSslIEYQLTDK 94
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAErlglSQSTVS-----RHLKKLEEAGLVESRREGRR--VYYSLTDA 66
COG1672 COG1672
Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];
37-93 3.91e-03

Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];


Pssm-ID: 441278 [Multi-domain]  Cd Length: 324  Bit Score: 35.66  E-value: 3.91e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1783231644  37 ILEVLIDGPHRFKDIAGSIPKcSDRVLVERLKELEGEGIVDRVTH-PNSSLIEYQLTD 93
Cdd:COG1672   250 ILKAIASGATRLSEIASALGI-SSSSLSRYLKNLIDLGIIEKEVPvEKSKKGRYRIAD 306
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
67-117 9.99e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 33.34  E-value: 9.99e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1783231644   67 LKELEGEGIVDRVTHPN---SSLIeyQLTDKGQGL-NQVLTAAHAWGDEW---LTDEE 117
Cdd:smart00347  45 LDRLEKKGLVRREPSPEdrrSVLV--SLTEEGRELiEQLLEARSETLAELlagLTAEE 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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