|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
19-448 |
1.71e-54 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 185.84 E-value: 1.71e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 19 LCVLSFFSVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGFV 98
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 99 GHSFfPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSYLLLIPTAT 178
Cdd:cd17321 81 APSL-AFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 179 IITVPFLIKLlkkeerirghidmagiilmsagivffmlfttsyrfsfliisilaffifvkhirkaqdpfvdpelgknvfF 258
Cdd:cd17321 160 GLVALLLART---------------------------------------------------------------------F 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 259 VIGTLCGGLIFGTAAGFVSMVPYMMKDVHHLSTTAIGsGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLSSGFL 338
Cdd:cd17321 171 SGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAG-LALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLL 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 339 IAAFFIDAAPWIMTIIVIFVFG-GLSFTKTVISTVVSSGLKEKEAGAGMSLLNFTSFLSEGTGIAIVGGLLSIGFLDH-- 415
Cdd:cd17321 250 LLALLGADSSVWLLLPGLVLLGlGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANlg 329
|
410 420 430
....*....|....*....|....*....|....*...
gi 1827977908 416 -----RLLPIDVDHSTYLYSNMLILFAGTIVICWLVIL 448
Cdd:cd17321 330 dsgvaALLSAAAAAFAAGFHLAFLVAAALALLAALLAL 367
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-395 |
8.55e-35 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 132.79 E-value: 8.55e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 6 SQSTLRHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFG 85
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 86 IMVNGLGSIIGFVGHSFfPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHY 165
Cdd:COG2814 82 LLLFALGSLLCALAPSL-WLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 166 IHWSYLLLIptatiitvpflikllkkeerirghidMAGIILMSAGIVFFMLFTTsyrfsfliisilaffifvKHIRKAQD 245
Cdd:COG2814 161 FGWRWVFLV--------------------------NAVLALLALLLLLRLLPES------------------RPAARARL 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 246 PFVDPELGKNVFFVIGTLCGGLIFGTAAGFVSMVPYMMKDVHHLSTTAIGSgIIFPGTMSVIIFGYIGGLLVDRKGSLYV 325
Cdd:COG2814 197 RGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGL-LLALFGLGGVLGALLAGRLADRFGRRRL 275
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 326 LTIGSALLSSGFLIAAFFidAAPWIMTIIVIFVFGGLSFTKTVISTVVSSGLKEKEAGAGMSLLNFTSFL 395
Cdd:COG2814 276 LLIGLLLLALGLLLLALA--GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
19-409 |
1.25e-32 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 127.31 E-value: 1.25e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 19 LCVLSFFSVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGFV 98
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 99 GHSFfPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSYLLLIptat 178
Cdd:cd17503 81 APNL-ASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYI---- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 179 iitvpflikllkkeerirghidmagiilmsagivffmlfttsyrfsFLIISILAFFIFvkhirkaqdPFVDPELGKNVFF 258
Cdd:cd17503 156 ----------------------------------------------NLPIGILALLLA---------PLLDLRLFKDRNF 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 259 VIGTLCGGLIFGTAAGFVSMVPYMMKDVHHLSTTAIGSgIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLSSGFL 338
Cdd:cd17503 181 TLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGL-VLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTL 259
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1827977908 339 IAAFFIDAAPWIMTIIVIFVFG-GLSFTKTVISTVVSSGLKEKEAGAGMSLLNFTSFLSEGTGIAIVGGLLS 409
Cdd:cd17503 260 LLAFLTPDTSLWLIILPLFIRGlGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLT 331
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
16-409 |
1.23e-30 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 123.64 E-value: 1.23e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 16 LIWLCVLSFFSVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSII 95
Cdd:TIGR00711 4 TIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 96 GFVGHSFfPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWS--YLLL 173
Cdd:TIGR00711 84 CGVAPNL-ELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRwiFLIN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 174 IPTATIITVPFLIKLLKKEERIRGHIDMAGIILMSAGIVFFML----------FTTSYRFSFLIISILAFFIFVKHIRKA 243
Cdd:TIGR00711 163 VPIGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYglsegpergwFDSNEILILSITGLVAIIAFVVWELTD 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 244 QDPFVDPELGKNVFFVIGTLCGGLIFGTAAGFVSMVPYMMKDVHHLSTTAIGSGIIfPGTMSVIIFGYIGGLLVDRKGSL 323
Cdd:TIGR00711 243 DNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHIL-PVGLAPMLSSPIAGRMGDKIDPR 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 324 YVLTIGSALLSSGF-LIAAFFIDAAPWIMTIIVIFVFG-GLSFTKTVISTVVSSGLKEKEAGAGMSLLNFTSFLSEGTGI 401
Cdd:TIGR00711 322 KLVTIGLILYAVGFyWRAFTFTPDTPFLAIALPQFIRGfGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGT 401
|
....*...
gi 1827977908 402 AIVGGLLS 409
Cdd:TIGR00711 402 ALITTILT 409
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
16-413 |
3.06e-28 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 114.98 E-value: 3.06e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 16 LIWLCVLSFFSVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSII 95
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 96 GFVGHSfFPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSYLLLIp 175
Cdd:cd17320 81 CALASS-IEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVF- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 176 tatiitvpflikllkkeerirghidMAGIILMSAGIVFFMLFTTSY--RFSFLIISILAFFIfvkhirkaqdpfvdpELG 253
Cdd:cd17320 159 -------------------------LALLGLLLLLLVLLFLPETLPeeKRKPLLSSLLRAYK---------------RVL 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 254 KNVFFVIGTLCGGLIFGTAAGFVSMVPYMMKDVHHLSTTAIGSGIIFPGtMSVIIFGYIGGLLVDRKGS---LYVLTIGS 330
Cdd:cd17320 199 KNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNA-IALILGSLLNGRLVRRFGPrrlLRLGLLLL 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 331 ALLSSGFLIAAFFIDAAPWIMTIIVIFVFGGLSFTKTVISTVVSSGLKEkEAGAGMSLLNFTSFLSEGTGIAIVGGLLSI 410
Cdd:cd17320 278 LAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPH-VAGTASALLGFLQFLIGALAGALVGLLPNG 356
|
...
gi 1827977908 411 GFL 413
Cdd:cd17320 357 TAL 359
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
19-411 |
4.45e-23 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 100.34 E-value: 4.45e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 19 LCVLSFFSVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGFV 98
Cdd:cd17474 4 VFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 99 GHSFFPILILaRFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVA----HYIHWSYLLLI 174
Cdd:cd17474 84 SDSFALLLAG-RALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAaiswRYPFFLLAALI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 175 PTATIITVPFLIKLLKKEERIRGHIDMAGIILMSagivffmlfttsyRFSFLIISILAFFIFVkhirkaqdpfvdpelgk 254
Cdd:cd17474 163 PVAFLAILFLLPEPKEKAKSSSATKLRDLKKALR-------------GRGLLTFLVSAFLYFF----------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 255 nVFFvigtlcgglifgtaaGFVSMVPYMMKDVHHLSTTAIGsGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLS 334
Cdd:cd17474 213 -LYF---------------AFLTYLPFLLELLYGISPIIIG-LLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLY 275
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1827977908 335 SGFLIAAFFIDAAPWIMTIIVIF-VFGGLSFtkTVISTVVSSGLKEKEAGAGMSLLNFTSFLSEGTGIAIVGGLLSIG 411
Cdd:cd17474 276 ALSLLLLGFVPSLALLLIAIVLFgLGLGLNL--PLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIF 351
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-456 |
2.44e-22 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 98.02 E-value: 2.44e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 11 RHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNG 90
Cdd:COG2271 7 YRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 91 LGSIIGFVGHSFFpILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWsy 170
Cdd:COG2271 87 LATLLFGFATSFW-QLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW-- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 171 llliptatiitvpflikllkkeerirghidmagiilmsagivffmlfttsyRFSFLIISILAFFIFVkhirkaqdpfvdp 250
Cdd:COG2271 164 ---------------------------------------------------RAAFLILGLPGLLLAL------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 251 elgknVFFVIGTLCGGLIFGTAAGFVSMVPYMMKDVHHLSTTAIGSGIIFPGTMSvIIFGYIGGLLVDRKGSLYVLTIGS 330
Cdd:COG2271 180 -----LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAG-IVGSLLGGWLSDRLGRRRKLVLAI 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 331 ALLSSGFLIAAFFIDAAPWIMTIIVIFVFGGLSFTKTVISTVVSSGLKEKEAGAGMSLLNFTSFLSEGTGIAIVGGLLsi 410
Cdd:COG2271 254 GLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL-- 331
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1827977908 411 gfldhrllpidvdhSTYLYSNMLILFAGTIVICWLVILNVYKRSRR 456
Cdd:COG2271 332 --------------DATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
19-403 |
2.44e-22 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 97.63 E-value: 2.44e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 19 LCVLSFFSVLNEMVLNVSLPDIANEFNKLpASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSII-GF 97
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFGGL-SLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLcGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 98 VGHSffPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSYLLLipta 177
Cdd:cd17502 80 APNM--TMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFY---- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 178 tiITVPFlikllkkeerirghidmagiilmsAGIVFFMLFTtsyrfsFLIISILAFFIfvkhirkaqdpfvdpelgknvf 257
Cdd:cd17502 154 --INLPI------------------------GGLALALLRT------ILLSSIFGFLF---------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 258 fvigtlCGGLIfgtaaGFVSMVPYMMKDVHHLSttAIGSGII-FPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLSS- 335
Cdd:cd17502 180 ------GGALF-----GLIYYLPLYFQLVLGDS--ATKSGVRlLPLIIGLVIGSIISGALISKTGRYKPLIVIGTILMSv 246
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1827977908 336 GFLIAAFFIDAAPWIMTIIVIFVFG-GLSFTKTVISTVVSSGLKEKEAGAGMSLLNFTSFLSEGTGIAI 403
Cdd:cd17502 247 GAGLLTTLTLDTSKWLLIGYLILLGlGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
19-408 |
2.21e-21 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 95.34 E-value: 2.21e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 19 LCVLSFFSVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGFV 98
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 99 GHSFfPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSYLLLIPTAT 178
Cdd:cd17325 81 ATSY-WQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 179 IItVPFLIKLLKKEERIRGHIDMAGIILMSAGIVFFMLFTTSYRFSFLIISILAFFIfvkhirkaqdpfvdpelgknvff 258
Cdd:cd17325 160 AL-LALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAF----------------------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 259 vigtlcgglifgtaAGFVSMVPYMMKDVHHLSTTAIGSgIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLSSGFL 338
Cdd:cd17325 216 --------------GALEPFLPLYAAELGGLSPAQIGL-LFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 339 IAAFFidAAPWIMTIIVIFVFGGLSFTKTVISTVVSSGLKEKEAGAGMSLLNFTSFLSEGTGiAIVGGLL 408
Cdd:cd17325 281 LLPLA--TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLG-PLLGGFL 347
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
16-408 |
3.04e-21 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 94.92 E-value: 3.04e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 16 LIWLCVLSFFSVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSII 95
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 96 GFVGHSFFpILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSYLLLIp 175
Cdd:cd17324 81 AALAPSFA-LLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLA- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 176 tATIITVPFLIKLLKKEERIRGHIDMAGIILMSagiVFFMLFTTSYRFSFLIisilaffifvkhirkaqdpfvdpelgkn 255
Cdd:cd17324 159 -IAVLALLAALLLWRLLPSLPPKKPGSLGLLSS---LLLLLRNPRLRLAYLI---------------------------- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 256 vffvigtlcGGLIFGTAAGFVSMVPYMMKDVHHLSTTAIgSGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLSS 335
Cdd:cd17324 207 ---------TFLLFGGFFALYTYLAPFLTDVPGFSSSAI-IGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA 276
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1827977908 336 GFLIaaFFIDAAPWIMTIIVIFVFGGLSFTKTVISTVVSSgLKEKEAGAGMSLLNFTSFLSEGTGiAIVGGLL 408
Cdd:cd17324 277 LLLL--TLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLR-LAPEARGLASSLYLAAYNLGGALG-AALGGLV 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
19-396 |
3.01e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 91.71 E-value: 3.01e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 19 LCVLSFFSVLNEMVLNVSLP-DIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGF 97
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 98 VGHSFFpILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSYLLLIPTA 177
Cdd:pfam07690 81 FASSLW-LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 178 TIITVPFLIKLLKKEERIRGHIDMAGIILMsaGIVFFMLFTTSYRFSFLIISILAFFIFvkhirkaqdpfvdpelgknvf 257
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLS--LIVAWKALLRDPVLWLLLALLLFGFAF--------------------- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 258 fvigtlcgglifgtaAGFVSMVPyMMKDVHHLSTTAIGsGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLSSGF 337
Cdd:pfam07690 217 ---------------FGLLTYLP-LYQEVLGLSALLAG-LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAA 279
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 338 LIAAFFIDAAPWIMTIIVIFVFG-GLSFTKTVISTVVSSGLKEKEAGAGMSLLNFTSFLS 396
Cdd:pfam07690 280 LGLLLLSLTLSSLWLLLALLLLGfGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLG 339
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
28-409 |
3.74e-20 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 91.48 E-value: 3.74e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 28 LNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGFVGHSfFPILI 107
Cdd:cd17504 10 LVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPN-LPVLI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 108 LARFIQGIGAAAFPaLVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSYLLLIPTATIITVPFLIK 187
Cdd:cd17504 89 AGRALQGIGGAVFP-LAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 188 LLKKEERIRGHIDMAGIILMSAGIVFFMLFTTSYRFsfliisilaffifvkhirkAQDPfvdpelgknvffvigtlcggl 267
Cdd:cd17504 168 LIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQL-------------------LQLP--------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 268 iFGTAAGFvsmvpymmkdvhhlstTAIGSGII-FPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLSSGFLIAAFFIDa 346
Cdd:cd17504 208 -TPTGFGL----------------GITEAGLLlLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHS- 269
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1827977908 347 APWIMTIIVIFVFGGLSFTKTVISTVVSSGLKEKEAGAGMSLLNFTSFLSEGTGIAIVGGLLS 409
Cdd:cd17504 270 SLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILT 332
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-237 |
4.54e-20 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 90.26 E-value: 4.54e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 1 MNTSYSQSTLRHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKN 80
Cdd:COG0477 1 MSSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 81 LLLFGIMVNGLGSIIGFVGHSFfPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGG 160
Cdd:COG0477 81 VLLIGLLLFGLASLLCGLAPSP-ELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGG 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1827977908 161 MVAHYIHWSYLLLIPTATIITVPFLIKLLKKEERIRGHIDMAGIILMSAGIVFFMLFTTSYRFSFLIISILAFFIFV 237
Cdd:COG0477 160 LLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAG 236
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
11-458 |
5.37e-19 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 88.40 E-value: 5.37e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 11 RHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNG 90
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 91 LGSIIGFVGHSFfPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSY 170
Cdd:COG2223 82 IGLLLLALAVSY-WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 171 LLLIptatiitvpflikllkkeerirghidmAGIILMSAGIVFFMLFTTSYRFSFliisilaffifvkhiRKAQDPFVDP 250
Cdd:COG2223 161 AFLI---------------------------LGILLLVVAVLAWLFLRDPPAGAA---------------AAAKASLRDQ 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 251 -ELGKNVFFVIGTLCGGLIFGTAAGFVSMVPYMMKDVHHLSTTAIGSgIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIG 329
Cdd:COG2223 199 lEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGL-LAALFALLGALGRPLGGWLSDRIGGRRVLLIV 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 330 SALLSSGFLIAAFFIDaAPWIMTIIVIFVFGGLSFTKTVISTVVSSGLKEKEAGAGMSLLNFTSFLSEGTGIAIVGGLLS 409
Cdd:COG2223 278 FALMALGLLLLALALG-SLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLD 356
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1827977908 410 IgfldhrllpidvdhsTYLYSNMLILFAGTIVICWLVILNVYKRSRRHR 458
Cdd:COG2223 357 A---------------TGSYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
16-360 |
2.27e-17 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 83.59 E-value: 2.27e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 16 LIWLCVLSFFSVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSII 95
Cdd:TIGR00710 7 ALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 96 GFVGHSFfPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSYLLlip 175
Cdd:TIGR00710 87 LALSNNI-ETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIF--- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 176 tatiitvpflikllkkeerirgHIDMAGIILMSAgIVFFMLFTTSYRFSFLIIS--ILAFFIFVKHIRkaqdpfvdpelg 253
Cdd:TIGR00710 163 ----------------------AFLSLAGILLSA-LIFFILPETLPYEARIQIStyFETFLLLLKSKM------------ 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 254 knvfFVIGTLCGGLIFGTAAGFVSMVPYMMKDVHHLSTTAIGSgIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALL 333
Cdd:TIGR00710 208 ----FWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGL-LFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILF 282
|
330 340
....*....|....*....|....*....
gi 1827977908 334 --SSGFLIAAFFIDAAPWIMTIIVIFVFG 360
Cdd:TIGR00710 283 avSAVLLEITAILGLGSWAMIIGPMMFVG 311
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
70-425 |
4.46e-15 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 77.08 E-value: 4.46e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 70 GKLSDQMGIKNLLLFGIMVNGLGSIIGFVGHSFFpILILARFIQGIGAAAF-PALVMVVVARYIPKENRGKAFGLIGSLV 148
Cdd:PRK14995 62 GALGDRIGFKRLLMLGGTLFGLASLAAAFSPTAS-WLIATRALLAIGAAMIvPATLAGIRATFTEEKQRNMALGVWAAVG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 149 AMGEGVGPAIGGMVAHYIHWSYLLLIPTATIITVPFLIKLL--KKEERIRGHIDMAGIILMSAGI--VFFMLFTTSYRFS 224
Cdd:PRK14995 141 SGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTARYvpRQAGRRDQPLNLGHALMLIVAIllLVYSAKTALKGFL 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 225 FLIISILAF-------FIFVKHIRKAQDPFVDPELGKNVFFVIGTLCGGLIFGTAAGFVSMVPYMMKDVHHLSTTAIGSG 297
Cdd:PRK14995 221 SLWVTSLTLltgalllGLFIRTQLAASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMF 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 298 IIfPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLSSGFL-IAAFFIDAAPWIM-TIIVIFVFGGLSFTKTVISTVVSS 375
Cdd:PRK14995 301 ML-PVMVASGFSGPIAGILVSRLGLRLVATGGMALSALSFYgLAMTDFSTQQWQAwGLMALLGFSAASALLASTSAIMAA 379
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1827977908 376 GLKEKEAGAGmSLLNFTSFLSEGTGIAIVGGLLSIGFLDHRLLPIDVDHS 425
Cdd:PRK14995 380 APPEKAAAAG-AIETMAYELGAGLGIAIFGLLLSRSYSASIRLPAGLPAQ 428
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
19-412 |
5.65e-15 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 76.31 E-value: 5.65e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 19 LCVLSFFSVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGFV 98
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 99 GHSFfPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSYLLLIPTAT 178
Cdd:cd06174 81 APSF-WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 179 IITVPFLIkllkkeerirghidmagiilmsagivFFMLFTTSYRFSFLIISILAFFIFVKHIRKaqdpfvdpELGKNVFF 258
Cdd:cd06174 160 ALALLAAI--------------------------LLLLVVPDPPESARAKNEEASSKSVLKLLK--------RVLKNPGL 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 259 VIGTLCGGLIFGTAAGFVSMVPYMMKDVHHLSTTAIGSGIIFPGTMSvIIFGYIGGLLVDRKGSLYVLTIGSALLSSGFL 338
Cdd:cd06174 206 WLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAG-ALGSLLLGLLSDRLIGRKPLLLIGLLLMALGL 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1827977908 339 IAAFFIDaAPWIMTIIVIFVFGGLSFTKTVISTVVSSGLKEKEAGAGMSLLNFTSFLSEGTGIAIVGGLLSIGF 412
Cdd:cd06174 285 ALLLLAP-SLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
17-430 |
1.44e-14 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 75.54 E-value: 1.44e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 17 IWLCVLSFF-SVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSII 95
Cdd:PRK10504 12 LWIVAFGFFmQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLF 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 96 GFVGHSFFPiLILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYI--HWSYLLL 173
Cdd:PRK10504 92 CALSGTLNE-LLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYAswHWIFLIN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 174 IPTATI--ITVPFLIKLLKKEERirgHIDMAGIILMSAGIVFFMLFTTSYR---------FSFLIISILAFFIFVKHIRK 242
Cdd:PRK10504 171 IPVGIIgaIATLMLMPNYTMQTR---RFDLSGFLLLAVGMATLTLALDGSKglglsplaiAGLVAVGVVALLLYLLHARN 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 243 AQDPFVDPELGKNVFFVIGtLCGGLIFGTAAGfvsMVPYMMKDVHHLsttAIGSGIIFPGTMSV-IIFGYIGG-----LL 316
Cdd:PRK10504 248 NNRALFSLKLFRTRTFSLG-LAGSFAGRIGSG---MLPFMTPVFLQI---GLGFSPFHAGLMMIpMVLGSMGMkrivvQV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 317 VDRKGSLYVL---TIGSALLSSGFLIAAFfidaAPWI-MTIIVIFVFGGLSFTK-TVISTVVSSGLKEKEAGAGMSLLNF 391
Cdd:PRK10504 321 VNRFGYRRVLvatTLGLALVSLLFMLVAL----LGWYyLLPFVLFLQGMVNSTRfSSMNTLTLKDLPDNLASSGNSLLSM 396
|
410 420 430
....*....|....*....|....*....|....*....
gi 1827977908 392 TSFLSEGTGIAIVGGLLSIGFLDHRLLPIDVDHSTYLYS 430
Cdd:PRK10504 397 IMQLSMSIGVTIAGLLLGLFGQQHVSVDSGATHTVFMYT 435
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
16-395 |
2.35e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 71.07 E-value: 2.35e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 16 LIWLCVLSFFSVLNEMVLNVSLPDIANEFNKLPA-SANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSI 94
Cdd:cd17473 1 LITLLLASTLTVMAGAAIAPALPAIAQHFVPNSElLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 95 IGFVGHSFFPILIlARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAhYIHWSYLLLI 174
Cdd:cd17473 81 AGLFLDSLYALLA-SRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 175 PTATIITVPFLIKLLKKEERIRGHIDMAGiilmsagivfFMLFTTSYRFSFLIISILAFFIFVkhirkaqdpfvdpelgk 254
Cdd:cd17473 159 YLLALPVLILVLLFLPEPARKSKSAASPG----------AATAAALPWKRVLPIYFLAFLAML----------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 255 nVFFVIgtlcgglifgtaagfVSMVPYMMKDVHHLSTTAIGSGIIFPGTMSVIIfGYIGGLLVDRKGSLYVLTIGSALLS 334
Cdd:cd17473 212 -LFYVI---------------PIQLPFLLQERGGGSAALIGLALAIASLAGAIG-ALLFGRLKRRLGKRRLLAIGFALMA 274
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1827977908 335 SGFLIAAFfidAAPWIMTIIVIFVFG-GLSFTKTVISTVVSSGLKEKEAGAGMSLLNFTSFL 395
Cdd:cd17473 275 LGFLLLAL---ASGLWVVLLGAILAGlGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFL 333
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
19-410 |
5.39e-12 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 66.83 E-value: 5.39e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 19 LCVLSFFSVLNEMVLNVSLPDIANEFNKLPASA---NWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSII 95
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASGyyvGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 96 gFVGHSFFPILILARFIQGIGAAAFPAlVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHwsylllip 175
Cdd:cd17330 81 -LGLSRNLWLLFLARFLDGLTGGNVSV-AQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYG-------- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 176 tatiITVPFLIkllkkeerirghidmagIILMSAGIVFFMLFTTSYRFSFLIISILAFFIFvkhirkaqdpfvdpelgkn 255
Cdd:cd17330 151 ----YALPFLV-----------------AAALALLNLVLVLFFLPPLRRLLLVYFLIALAF------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 256 vffvigtlcgglifgtaAGFVSMVPYMMKDVHHLSTTAIGSGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLSS 335
Cdd:cd17330 191 -----------------AGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAII 253
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827977908 336 GFLIAAfFIDAAPWIMTIIVIFVFGGlSFTKTVISTVVSSGLKEKEAGAGMSLLNFTSFLSEGTGIAIVGGLLSI 410
Cdd:cd17330 254 GLLLLP-FASSVPLLVLAAAILAFGT-GIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSF 326
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
69-408 |
1.82e-11 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 65.31 E-value: 1.82e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 69 YGKLSDQMGIKNLLLFGIMVNGLGSIIGFVGHSFfPILILARFIQGIGAAAfpALVMVVVARYIPKENRGKAFGLIGSLV 148
Cdd:cd17472 52 FGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSI-YGLILGRALQGSGAIS--SVVMALLADLTREENRTKAMALIGASI 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 149 AMGEGVGPAIGGMVAHYIHWSYLLLIpTATIITVPFLI--KLLKKEERIRGHIDMAgiILMSAGIVFFMLFTTSYrFSFL 226
Cdd:cd17472 129 GIAFAISMVLGPLLAAHLGVSGLFLI-TAILSLVSLLIllFFVPDPPKIVQISEKE--KKKLKKLLKNKRLLRLD-FSIF 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 227 IISILAFFIFVkhirkaqdpfVDPELGKNVFFVIGTLCGGLIFGTAAGFVSMVPYMmkdvhhlsttaigsgiifpgtmsv 306
Cdd:cd17472 205 ILHFVLMAFFY----------ILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFV------------------------ 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 307 iifgyiggLLVDRKGSLY-VLTIGSALLSSGFLIAAFFIDAAPWIMTIIVIFvFGGLSFTKTVISTVVSSGLKEKEAGAG 385
Cdd:cd17472 251 --------IYAEKKGKMKqVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIF-FIGFNLLEALLPSLVSKIAPKEYRGTA 321
|
330 340
....*....|....*....|...
gi 1827977908 386 MSLLNFTSFLSEGTGiAIVGGLL 408
Cdd:cd17472 322 MGIYNTSQFLGSFLG-GALGGLL 343
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
14-408 |
1.90e-11 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 65.28 E-value: 1.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 14 QVLIWLCVLSFFSVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGS 93
Cdd:cd17319 3 RIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 94 IIGFVGHSFfPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSYLLL 173
Cdd:cd17319 83 ALTGFATSL-TSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 174 IptatiitvpflikllkkeerirghidMAGIILMSAGIVFFMLFTTsyrfsfliisilaffifvkhirkaqdpfvdpelg 253
Cdd:cd17319 162 I--------------------------EGLLGLLLAVLWWFYLRQV---------------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 254 knVFFVIGTLCGGLIFGtaaGFVSMVPYMMKDVHHLSTTAIGSGIIFPGTMSViIFGYIGGLLVDR--KGSLYVLTIGSA 331
Cdd:cd17319 182 --WGLALGYFGINYALY---GLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGA-IGMILGGRLSDRllRGARRLVIIIGL 255
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1827977908 332 LLSSGFLIAAFFIDAAPWIMTIIVIfVFGGLSFTKTVISTVVSSGLKEKEAGAGMSLLNFTSFLSEGTGIAIVGGLL 408
Cdd:cd17319 256 LLAAVGLLLAYLTTSPVVAVILLSL-AGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLV 331
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
36-409 |
3.44e-11 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 64.55 E-value: 3.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 36 SLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGFVGHSfFPILILARFIQGI 115
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQT-IDQLIYMRFLHGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 116 GAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSY----LLLIPTATIITVPFLIK-LLK 190
Cdd:PRK11102 92 AAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAifwvLALAAILAAALVFFFIPeTLP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 191 KEERIRGHIdmaGIILMSagivFFMLFTTSYRFSFLiisilaffifvkhirkaqdpfvdpelgknvffvigtLCGGLIFG 270
Cdd:PRK11102 172 KERRQPFHL---RTTIRN----FASLFRHKRVLGYM------------------------------------LASGFSFA 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 271 TAAGFVSMVPYMMKDVHHLSTTAIGS----GIIFPGTMSViifgyIGGLLVDRKGSLYVLTIGSA--LLSSGFLIAAFFI 344
Cdd:PRK11102 209 GMFSFLTAGPFVYIELNGVSPQNFGYyfalNIVFLFVMTI-----INSRFVRRVGALNMLRFGLWiqFIMGIWLVVSALL 283
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1827977908 345 DAAPWIMTIIVIFVFGGLSftkTVISTVVSSGLKE--KEAGAGMSLLNFTSFlseGTGiAIVGGLLS 409
Cdd:PRK11102 284 DLGFWALVVGVAAFVGCVS---MISSNAMAVILDEfpHMAGTASSLAGTLRF---GIG-AIVGALLS 343
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
36-173 |
3.95e-11 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 64.54 E-value: 3.95e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 36 SLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGFVGHSfFPILILARFIQGI 115
Cdd:PRK11652 30 AIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHS-LTVLIAASAIQGL 108
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827977908 116 GAAafpalVMVVVARYIPKEN-RGKAFGLIGSLVAMG----EGVGPAIGGMVAHYIHW--SYLLL 173
Cdd:PRK11652 109 GTG-----VGGVMARTLPRDLyEGTQLRHANSLLNMGilvsPLLAPLIGGLLTTLFGWraCYLFL 168
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
19-412 |
7.23e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 63.38 E-value: 7.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 19 LCVLSFFSVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGFV 98
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 99 GHSFFpILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHyiHWSYLLLIPTAT 178
Cdd:cd17489 81 ATSVA-LLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQ--HLGFAVLFIVAA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 179 IITVpflikllkkeerirghidmagiilmsagIVFFMLFTTSYRFSFLIISILAFFIFVKHIRkaqdpfvdpeLGKNVFF 258
Cdd:cd17489 158 VLAL----------------------------LALLLVFLVKDPPPVAAEEAEAGTRAFRRLV----------EKKVLPP 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 259 VIGTLCGGLIFGTAAGFVSMvpYMMKdvHHLSTTAIGSgIIFPGTMsvIIFGYIGGLLVDRKGSLYVLTIGSALLSSGFL 338
Cdd:cd17489 200 ALILFLASIAYGAISTFLPL--YAAE--RGISNAGLFF-TVYAIAL--LLSRPFSGKLSDRKGPKTVIIPGLLLLALGLL 272
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827977908 339 IAAFfidAAPWIMTIIVIFVFG-GLSFTKTVISTVVSSGLKEKEAGAGMSLlnFTSFLSEGTGI-AIVGGLLSIGF 412
Cdd:cd17489 273 LLSF---AGSPWMLLLAAVLYGlGFGLLFPALQALAVDLVPPHRRGAANGT--FFIFFDLGIGLgGLLLGLVAELF 343
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
19-358 |
1.25e-10 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 63.02 E-value: 1.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 19 LCVLSFFSVLNEM---VLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSII 95
Cdd:cd17328 1 VAVLFLINLLNYMdrfTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 96 -GFVGHsfFPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYI-HWSYLLL 173
Cdd:cd17328 81 sSFAPN--FWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 174 I-PTATIITVPFLikLLKKEERIRGHID---MAGIILMSAGIVFFMLFTTSyrfSFLIISiLAFFIfvkhirkaqdpfvd 249
Cdd:cd17328 159 VtGVLGVLLAILL--LLFVREPPRGAAEggvMAKSTATSFLADLKALAKNP---SFILST-LGFTA-------------- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 250 pelgknVFFVIGTLCgglIFGTAAGFVSMVPYMMKDVHhlSTTAIGSGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIG 329
Cdd:cd17328 219 ------VSFVTGALA---FWAPTFFLRAFGVGDLSSAD--VGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCA 287
|
330 340 350
....*....|....*....|....*....|
gi 1827977908 330 SALLSSG-FLIAAFFIDAAPWIMTIIVIFV 358
Cdd:cd17328 288 VGLLAAApFLFLALVLALSNLLLAWVLLFL 317
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
16-409 |
3.35e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.48 E-value: 3.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 16 LIWLCVLSFFSVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSII 95
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 96 GFV----GHSFFPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSYL 171
Cdd:cd06173 81 LALlallGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 172 LLIPTATIITVPFLIKLLKKEERIRGHIdmagiilmsagivffmlfttsyRFSFLIISILAFFIFVKHIRKAqdpfvdpe 251
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPPAAPGE----------------------SSSLLLRDLREGLRYLRRSPLL-------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 252 lgknvffVIGTLCGGLIFGTAAGFVSMVPYMMKDVHHLSTTAIGsgiIFPGTMSV--IIFGYIGGLLVDRKGSLYVLTIG 329
Cdd:cd06173 211 -------RLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYG---LLLAAFGVgaLLGALLLGRLSKRRRRGRLLLIG 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 330 SALLSSGFLIAAFfidAAPWIMTIIVIFVFG-GLSFTKTVISTVVSSGLKEKEAGAGMSLLNFTSFLSEGTGIAIVGGLL 408
Cdd:cd06173 281 ALLLGLALLVLGL---SPSLWLLLAALFLLGlAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLA 357
|
.
gi 1827977908 409 S 409
Cdd:cd06173 358 D 358
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
1-362 |
3.70e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 61.43 E-value: 3.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 1 MNTSYSQSTLRHNQVLIWLCVLSFFSVLNEMVLNVS----LPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQM 76
Cdd:COG2807 1 MSTTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSvgplLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 77 GIKNLLLFGIMVNGLGSIIGFVGHSfFPILILARFIQGIGAAAFPALVMVVVARYIPKeNRGKAFGLIGSLVAMGEGVGP 156
Cdd:COG2807 81 GLERTLLLALLLLAAGLLLRSLAPS-VALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 157 AIGGMVAHYIHWSYLLLIptatiitvpflikllkkeerirghidMAGIILmsagivffmlfttsyrfsfliISILAFFIF 236
Cdd:COG2807 159 GLTVPLAAALGWRGALAV--------------------------WALLAL---------------------LALLLWLPL 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 237 VKHIRKAQDPFVDPELGKNVF----FVIGTLCGGLIFGTAAGFVSMVPYMMKDvHHLSTTAIGSgIIFPGTMSVIIFGYI 312
Cdd:COG2807 192 LRRRPAAAAAAPAAASLRSLWrsplAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGL-LLSLFQLAGIPGSLL 269
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1827977908 313 GGLLVDRKGSLYVLTIGSALLS-SGFLIAAFFIDAAPWIMTIIVIFVFGGL 362
Cdd:COG2807 270 VPLLADRLGDRRPLLLLLGLLGlAGLLGLLLAPGSLPWLWAVLLGLGQGGL 320
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
49-409 |
5.87e-10 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 61.10 E-value: 5.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 49 ASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGFVGHSfFPILILARFIQGIGAAAFPaLVMVVV 128
Cdd:cd06179 32 SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKS-VNMLIGGQALIGIGAGTQG-LGAAVA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 129 ARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIH----WSYLLLIPTATIITVPFLI-----KLLKKEERIRG-- 197
Cdd:cd06179 110 SELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAagwrWIFYINAIFNALALILLFFfyhppPRPQLHGSSTRqk 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 198 --HIDMAGIILMSAGIVFFMLF----TTSYRFS------FLIISILAFFIFVKH-IRKAQDPFVDPELGKNV--FFVIGT 262
Cdd:cd06179 190 lkRLDWVGLFLLIAGLVLFLLGlswgGNPYPWSsahviaPLVIGGVLLIAFGLYeWKGTKDGLLPPRLLFRGrnFALILI 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 263 LC--GGLIF-GTAAGFVSMVPYMmkdvhhLSTTAIGSGIIFPGTMSVIIFGYIG-GLLVDRKGSLYVLTIGSALLSSGFL 338
Cdd:cd06179 270 VAfvEGMIFySLNIFWPQQISLL------FTTDPLKAGLYQLPFGLGTLFGAILaGLLLTKIKHIKWQLVAGFVLFTAFL 343
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1827977908 339 IAAFFIDAAPWIMTIIVIFVFG-GLSFTKTVISTVVSSGLKEKEAGAGMSLLNFTSFLSEGTGIAIVGGLLS 409
Cdd:cd06179 344 ALLALITPDNKALAIAFSVLAGiGIGGPLVLAIVIVQLSVPPEDIGTASGLLGSARALGGAVGTAIFTSILS 415
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
1-363 |
2.15e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 59.29 E-value: 2.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 1 MNTSYSQSTLRHNQVLIWLC-VLSFFSVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIK 79
Cdd:TIGR00895 3 QNNIRKQPLSRYQWRAIILSfLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 80 NLLLFGIMVNGLGSIIGFVGHSFfPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIG 159
Cdd:TIGR00895 83 RVLLWSILLFSVFTLLCALATNV-TQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 160 GMVAHYIHWSYLLLIPT-ATIITVPFLIKLLKKEERIRGHIDMAGIILMSAGIVFFMLFTTSYRFSFLIisilaffIFVK 238
Cdd:TIGR00895 162 GWLIPVFGWRSLFYVGGiAPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQK-------STQG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 239 HIRKAQDPFVDPELGKN-VFFVIGTLCGGLIFgtaAGFVSMVPYMMKDVHHLSTTAIGSGIIFpgTMSVIIFGYIGGLLV 317
Cdd:TIGR00895 235 TKRSVFKALFQGKTARItVLLWLLYFMLLVGV---YFLTNWLPKLMVELGFSLSLAATGGALF--NFGGVIGSIIFGWLA 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1827977908 318 DRKGSLYVLTIgsALLSSGFLIAAFFIDAAPWIMTIIV----IFVFGGLS 363
Cdd:TIGR00895 310 DRLGPRVTALL--LLLGAVFAVLVGSTLFSPTLLLLLGaiagFFVNGGQS 357
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
19-186 |
2.32e-09 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 58.74 E-value: 2.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 19 LCVLSFFSVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGFV 98
Cdd:cd17323 4 ISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 99 GHSFFPILILaRFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHW---SYLLLIP 175
Cdd:cd17323 84 APNIAMLIIL-RFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWrwiFWFLAII 162
|
170
....*....|.
gi 1827977908 176 TATIITVPFLI 186
Cdd:cd17323 163 SGFCLILIFLF 173
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
30-199 |
5.20e-09 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 58.10 E-value: 5.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 30 EMVLNVSLPDIANEFNkLPASANWVN----TAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGFVGHSFFPI 105
Cdd:TIGR00898 105 EYSYDTFSSTIVTEWD-LVCEDAWKVdltqSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVF 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 106 LILaRFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAhyiHWSYLLLipTATIITVPFL 185
Cdd:TIGR00898 184 LVF-RLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIP---DWRWLQL--AVSLPTFLFF 257
|
170
....*....|....
gi 1827977908 186 IKLLKKEERIRGHI 199
Cdd:TIGR00898 258 LLSWFVPESPRWLI 271
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
56-174 |
7.17e-09 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 57.17 E-value: 7.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 56 TAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIiGFVGHSFFPILILARFIQGIGAAAFPALVMVVVARYIPKE 135
Cdd:cd17370 241 ALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYL-GFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAE 319
|
90 100 110
....*....|....*....|....*....|....*....
gi 1827977908 136 NRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSYLLLI 174
Cdd:cd17370 320 LRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLF 358
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
37-408 |
1.41e-08 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 56.49 E-value: 1.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 37 LPDIANEFNKLPASANWVNTAFMLTFS----IGTALYGKLSDQMGIKNLLLFGImvngLGSIIGFVGHSFFP---ILILA 109
Cdd:cd17388 22 LPTLLREFVGDSADAATHYGVLLALYAlmqfIFAPILGALSDRFGRRPVLLLSL----AGAALDYLLMAFAPtlwWLYLG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 110 RFIQGIGAAAFpALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHyiHWSYLLLIPTATIITVPFLIKLL 189
Cdd:cd17388 98 RIIAGITGATG-AVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGE--ISPRAPFLVAAGLNGLNFLLGLF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 190 -----KKEERIRGHIDMAGIILMSagivffmlftTSYRFSFLIISILAFfifvkhirkaqdpfvdpelgknVFFVIGtlc 264
Cdd:cd17388 175 vlpesLPPERRRAFRWRRANPFGS----------LRWLTGFPGLLGLLA----------------------VFFLIQ--- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 265 ggliFGTAAGFVSMVPYMMkDVHHLSTTAIGSGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLSSGFLIAAfFI 344
Cdd:cd17388 220 ----LIGQVPATTWVLFTE-DRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLA-FA 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1827977908 345 DAAPWIMTIIVIFVFGGLSFT--KTVISTVVSSGLKEKEAGAGMSLLNFTSflsegtgiaIVGGLL 408
Cdd:cd17388 294 TQGWMVFPILILLALGGIAGPalQGLLSRQVPENEQGELQGVLTSLTSLTS---------IIGPLL 350
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
18-365 |
2.37e-08 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 55.77 E-value: 2.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 18 WLCVLSF-FSVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIG 96
Cdd:cd17371 2 WAAFLGWaLDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 97 FVGHSFFPILILaRFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHY----IHWSYLL 172
Cdd:cd17371 82 GFAQNYWQLLIL-RALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLlppeIAWRVLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 173 LIPTATIITVPFLIKLLKKEERIRGHidMAGIILMSAGIVFFMLFTTSYRFSFLIISILAffifvkhirkaqdpfvdpel 252
Cdd:cd17371 161 LLGALPALLVLFIRRFVKEPPQWQAA--RAARRHFADRPSLRELFSPPLLRTTLLASLLA-------------------- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 253 gknvffvigtlcGGLIFGtAAGFVSMVPYMMKDVHHLSttAIGSGIIFPGTMSVIIFGYI-GGLLVDRKGSLYVLTIGsA 331
Cdd:cd17371 219 ------------TGALGG-YYGITTWLPSYLTGERGLS--FEGSAGYLVVTILGGFLGYLaGGFLADRIGRRNNFALF-A 282
|
330 340 350
....*....|....*....|....*....|....*...
gi 1827977908 332 LLSSGFLIAAFFIDAAP----WIMTIIVIFVFGGLSFT 365
Cdd:cd17371 283 LGSAISILLYFFLPLSPtlilILGFPLGFFASGPFSGM 320
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
35-405 |
4.67e-08 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 54.96 E-value: 4.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 35 VSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGFVGHSfFPILILARFIQG 114
Cdd:cd17476 19 VILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPN-FIFFIICRALQG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 115 IGAAAFPALVMVVVAR-YIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWsyllliptatiitvpflikllkkee 193
Cdd:cd17476 98 LGPAFLLPNAMALLGRtYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWW------------------------- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 194 rirghidmagiilmsagivffmlfttsyRFSFLIISILAFFIFVKHIrkaqdpfvdpeLGKNVFFVIGTLCGGLIFGTAA 273
Cdd:cd17476 153 ----------------------------PWIFWFLAILAAIVAVAAI-----------FWTSPSFIAVLLAVFLGWASFG 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 274 GFVSMVPYMMKDVHHLSTTaIGSGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALlssgFLIAAFFIDAAP----- 348
Cdd:cd17476 194 IWVFYATQYFQNVRGYSPL-LTSARFIPMAIGGVLAAITVGFLIARLPPSYIMAISMVA----FLVGPILFATMPvhqty 268
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1827977908 349 WIMTIIVIFVFG-GLSFTKTVISTVVSSGLKEKEAGAGMSLLNFTSFLSEGTGIAIVG 405
Cdd:cd17476 269 WAQAFPAMIVAPfGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVNYGISIGLGIAG 326
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
16-163 |
2.00e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 52.59 E-value: 2.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 16 LIWLCVLSFFSVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSII 95
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1827977908 96 GFVGHSFFpILILARFIQGIGAAAFPALVMVVVARYIPKENRgkafGLIGSLVAMGEGVGPAIGGMVA 163
Cdd:cd17365 81 TAFAQSVL-QLALLRFLTGLGLGAAMPNAITLVSEYAPARRR----SLAVTLMFCGYPLGAALGGFLA 143
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
10-189 |
2.49e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 52.62 E-value: 2.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 10 LRHNQVLIWLCVLSFFSVLNeMVLNVSLPDIANE-FNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMV 88
Cdd:cd06173 205 RRSPLLRLLLLALALFALLG-GALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 89 NGLGSIIGFVGHSFFPILILArFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHW 168
Cdd:cd06173 284 LGLALLVLGLSPSLWLLLAAL-FLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGL 362
|
170 180
....*....|....*....|.
gi 1827977908 169 SYLLLIPTATIITVPFLIKLL 189
Cdd:cd06173 363 SAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
32-407 |
5.43e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 51.40 E-value: 5.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 32 VLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGFVGHSFFPILILArF 111
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV-A 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 112 IQGIGAAAFPALVMVVVARYiPKENRGKAFGLIGSLVAMGEGVGPAIGGM-VAHYIHWSYLLLIPTATIITVPFLIKLLK 190
Cdd:cd17478 93 LAGIGSAAFHPEGARLASQA-AGGRRGLAMSIFSVGGNLGFALGPLIAAAlVALFGGLGLLILLIIPGLAVALLLLRLRP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 191 KEERIRGHIDMAGIIlmsagivffmlfTTSYRFSFLIISILAFFIFVKHIrkaqdpfvdpelgknvffvigtlcgglifg 270
Cdd:cd17478 172 LKKPEAKKAAAKSSA------------RSTLKGVWRALLLLLIIVFLRSW------------------------------ 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 271 TAAGFVSMVPYMMkdVHHLSTTAIGSGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIgSALLSSGFLIAAFFidaAPWI 350
Cdd:cd17478 210 VLSSLTTFLPFYL--VQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIA-SLLLAAPFLLLFLL---TPGI 283
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1827977908 351 MTIIVIFVFGGLSFTKTVISTVVSSGLKEKEAGAGMSLLNFTSFLSEGTGIAIVGGL 407
Cdd:cd17478 284 WSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGLMMGLSFGLGGIGAPVLGAL 340
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
1-190 |
6.96e-07 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 51.12 E-value: 6.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 1 MNTSYSQSTLRHNQVLIWLC-VLSFFSVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIK 79
Cdd:PRK11551 1 MSTRTSSASSSRLALTIGLCfLVALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 80 NLLLFGIMVNGLGSII-GFVghSFFPILILARFIQGIG-AAAFPALVmVVVARYIPKENRGKAFGLIGSLVAMGEGVGPA 157
Cdd:PRK11551 81 RILIVSVALFGLFSLAtAQA--WDFPSLLVARLLTGVGlGGALPNLI-ALTSEAVGPRLRGTAVSLMYCGVPFGGALASV 157
|
170 180 190
....*....|....*....|....*....|....
gi 1827977908 158 IGGMVAHYIHWSYLLLI-PTATIITVPFLIKLLK 190
Cdd:PRK11551 158 IGVLAAGDAAWRHIFYVgGVGPLLLVPLLMRWLP 191
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
70-356 |
7.21e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.07 E-value: 7.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 70 GKLSDQMGIKNLLLFGIMVNGLGsIIGFVGHSFFPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVA 149
Cdd:cd17329 56 GRLADRFGRKPVMLAGLLLRALG-FALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAIN 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 150 MGEGVGPAIGGMVAHYiHWSYLLLIPTATIITVPFLIKLLKKEERIRGHIDMAGIILMSAGIVFfmlfttsyrfsfliis 229
Cdd:cd17329 135 LGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVL---------------- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 230 ilaffifvkhirkaqdpfvdpelgKNVFFVIGTLCGGLIFGTAAGFVSMVPYMMKDVHHLSTTAIGSGIIFPGTMsVIIF 309
Cdd:cd17329 198 ------------------------RDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALL-IVLL 252
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1827977908 310 GYIGGLLVDRKGSLYVLTIGSALLSSGFLIAAFFIDAAPWIMTIIVI 356
Cdd:cd17329 253 QFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVL 299
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
68-163 |
8.14e-07 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 51.12 E-value: 8.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 68 LYGKLSDQMGIKNLLLFGIMVNGLGSIIGFVGHSFfPILILARFIQGIGAAAFpALVMVVVARYIPKENRGKAFGLIGSL 147
Cdd:cd17389 83 ITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSF-TIFLLSRIVGGISKGNV-SLSTAIVADVTSPKKRSKGMALIGVA 160
|
90
....*....|....*.
gi 1827977908 148 VAMGEGVGPAIGGMVA 163
Cdd:cd17389 161 FSLGFIIGPMIGAYFA 176
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
31-364 |
8.33e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 50.68 E-value: 8.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 31 MVLNVSLPDIANEFNKLPASAN--WVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGFVGHSFfPILIL 108
Cdd:cd17316 16 FLIGFVAPVLAAEFSLGLSLLQtgLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTP-ILLLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 109 ARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGegvgpaiggmvahyihwsyllliptatiitvpflikl 188
Cdd:cd17316 95 LRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALG------------------------------------- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 189 lkkeerirghidMAGIILMSAGIVFFMLFTTSYRFSFLIISILAFFIFVkhIRKaqdpfvdpelgknvFFVIGTLCGGLI 268
Cdd:cd17316 138 ------------ALLAALVASLLIPLLSGDWGWRILFLIGALPALLALL--LRR--------------RTLLLILLWFFI 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 269 FGTAAGFVSMVPYMMKDVHHLSTTAIgSGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLtIGSALLSSGFLIAAFFIDAAP 348
Cdd:cd17316 190 SFGYYGLTTFLPTYLQTVLGLSPATS-SLYLLLISLGALVGALIAGLLSDRIGRKKTL-VIGLILSGILALPLFYLLSGS 267
|
330
....*....|....*.
gi 1827977908 349 WIMTIIVIFVFGGLSF 364
Cdd:cd17316 268 PTLLLLLLFILSFFVG 283
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
8-167 |
8.86e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 51.06 E-value: 8.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 8 STLRHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEFNKLPAS-ANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGI 86
Cdd:COG2211 222 KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAAlVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGL 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 87 MVNGLGSII-GFVGHSFFPILILARFIQGIGAAAFPALVMVVVARYIP-------KENRGKAFGLIGSLVAMGEGVGPAI 158
Cdd:COG2211 302 LLAALGLLLlFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGAL 381
|
....*....
gi 1827977908 159 GGMVAHYIH 167
Cdd:COG2211 382 AGLLLALFG 390
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-151 |
9.69e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 50.74 E-value: 9.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 6 SQSTLRHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEFNKLPAS-ANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLF 84
Cdd:COG2814 199 SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASaAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLI 278
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1827977908 85 GIMVNGLGSIIGFVGHSFFPILILArFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMG 151
Cdd:COG2814 279 GLLLLALGLLLLALAGSLWLLLLAL-FLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
40-170 |
1.10e-06 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 50.63 E-value: 1.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 40 IANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIG-FVGHSFFPILILARFIQGIG-A 117
Cdd:cd17380 25 MAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTpLLAYSSLPLLILSRILLGLGeG 104
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1827977908 118 AAFPALVMVVvARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSY 170
Cdd:cd17380 105 VHFPSMTSLF-SRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPS 156
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
56-176 |
2.68e-06 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 49.51 E-value: 2.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 56 TAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSI-IGFVGHSffPILILARFIQGIGAAAfpALVM---VVVARY 131
Cdd:PRK11043 48 SLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLgMLWVESA--AQLLVLRFVQAVGVCS--AAVIwqaLVIDRY 123
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1827977908 132 iPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHW----------SYLLLIPT 176
Cdd:PRK11043 124 -PAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWqaifatlfaiTLLLILPT 177
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
195-411 |
3.11e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.13 E-value: 3.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 195 IRGHIDMAGIILMSAGIVFFMLF-----TTSYRFSFLIISILAFFIFVKHIRKAQDPFVDPELGKNVFFVIGT------- 262
Cdd:COG2211 151 WRFAFAGLGGLLASVLPPPLVAAfggdaALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKAllknrpf 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 263 --LCGGLIFGTAAGFV--SMVPYMMKDVHHLSTTAIGsGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLSSGFL 338
Cdd:COG2211 231 llLLLAYLLFFLALALvaALLLYYFKYVLGLSAALVG-LLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 339 IAAFFIDAAPWIMTIIVIFVFGGLSFTKTVISTVVS-------SGLKEKEAGAGMSLLNFTSFLSEGTGIAIVGGLLSIG 411
Cdd:COG2211 310 LLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLAdvvdydeWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALF 389
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
15-193 |
6.17e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 48.04 E-value: 6.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 15 VLIWLCVLSFFsvLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSI 94
Cdd:cd17312 6 LGVFLGYAAYY--VCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 95 IGFVGHSFFPILILARFIQGIGAAAFPALVMVVVARYIPKEnRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSYLLLI 174
Cdd:cd17312 84 FMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKE-RGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLV 162
|
170
....*....|....*....
gi 1827977908 175 PTATIITVPFLIKLLKKEE 193
Cdd:cd17312 163 PGIVGLVVAIILFFFLRDS 181
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
11-413 |
1.02e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 47.54 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 11 RHNQVLIWLCVLSFFSV-LNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVN 89
Cdd:COG0738 4 KNYRRALIAIYLLFFLWgFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 90 GLGSIIGFVGHSfFPILILARFIQGIGAAAFPALVMVVVARyIPKENRGKAFGLIGSLVAMGEGVGPAIGGmvahyihws 169
Cdd:COG0738 84 ALGLLLFALAPS-YPLLLLALFLLGLGLGLLDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGG--------- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 170 YLLLIPTATIITVPFLIkllkkeerirghidMAGIILMSAGIVFFMLFTTsyrfsfliisilaffIFVKHIRKAQDPFVD 249
Cdd:COG0738 153 LLILLGLSLSWHLPYLI--------------LAVLLLLLALLFLRSKLPE---------------IEEEEEEAAGSAASL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 250 PELGKNVFFVIGTLCGGLIFGTAAGFVSMVPYMMKDVHHLSTTAIGSGIIFpgTMSVIIFGY-IGGLLVDRKGSLYVLTI 328
Cdd:COG0738 204 KSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSL--FWGGMTIGRfLGGFLLKRFGPVRLLRL 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 329 GSALLSSGFLIAAFfidaAPWIMTIIVIFVFGGLsFTKTVISTVVSSGLK--EKEAGAGMSLLnftsflsegTGIAIVGG 406
Cdd:COG0738 282 SALLAAVGLLLALL----APGPWLALIGLALVGL-GLSLMFPTIFSLALDglGKRTAAAVSAV---------LIMGIVGG 347
|
410
....*....|
gi 1827977908 407 LLS---IGFL 413
Cdd:COG0738 348 AIGpplIGFL 357
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
70-413 |
5.13e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 45.23 E-value: 5.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 70 GKLSDQMGI-KNLLLFGIMVNGLGSIIGFVGHSFFPIL---ILARFIQGIGAAAFPALVmvvvARYIPKENRGKAFGLIG 145
Cdd:cd17370 55 GYLSDRTGKrKPLVILGYGLSALAKPLLALAGSWQLVLllrILERLGKGIRTPPRDALL----ADATPPSGRGKAFGLHR 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 146 SLVAMGEGVGPAIGGMVAHYIHWSYLLLIPTATIItvpflikllkkeerirghidmagiilmsagivffmlfttsyrfsf 225
Cdd:cd17370 131 ALDTLGAVLGPLLAALLLYLLGGNYRTIFLLAAIP--------------------------------------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 226 LIISILAFFIFVKHIRKAQDPFVDPELGKNVFF---VIGTLCGGLIFGTAAGFVSMVPYMMKDVHHLSTTAIGSGIIFPG 302
Cdd:cd17370 166 ALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLpkaFWLYLLAVALFALGNFSFAFLILRAQELGLSAALIPLLYALFNL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 303 TMSviIFGYIGGLLVDRKGSLYVLTIGsaLLSSGFLIAAFFIDAAPWIMTIIVIFVFGGLSFTKTVISTVVSSGLKEKEA 382
Cdd:cd17370 246 VYA--LAAYPAGRLSDRIGRKKLLILG--YLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELR 321
|
330 340 350
....*....|....*....|....*....|.
gi 1827977908 383 GAGMSLLNFtsflseGTGIAIVGGLLSIGFL 413
Cdd:cd17370 322 GTAYGLFNT------VVGIGWLLASLIAGYL 346
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
8-162 |
1.28e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 44.11 E-value: 1.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 8 STLRHNQVLIwLCVLSFFSVLNEMVLNVSLPDIANE-----FNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLL 82
Cdd:cd17504 172 RLLRRRNVLL-ANITALLAGFGMFMVFQLLPQLLQLptptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 83 LFGIMVNGLGSIIGFVGHSFFPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMV 162
Cdd:cd17504 251 LIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
18-194 |
1.60e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 43.85 E-value: 1.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 18 WLCVLSFFSVLNEMVlnVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGF 97
Cdd:cd17333 2 YISFFSNGLTDALLG--ILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 98 VGHSfFPILILARFIQGIGAAAFPALVMVVVARYIPkENRGKAFGLIGSLVAMGEGVGPAIGG-MVAHYIHWSYLLLIPT 176
Cdd:cd17333 80 ATPS-IYLFVVLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAYLIIG 157
|
170
....*....|....*...
gi 1827977908 177 ATIITVPFLIKLLKKEER 194
Cdd:cd17333 158 LIYLLLAILILLTLFPEL 175
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
56-189 |
2.27e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.41 E-value: 2.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 56 TAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGFVGHSFFPILILARFIQGIGAAAFPALVMVVVARYIPKE 135
Cdd:cd17355 45 TVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFER 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1827977908 136 NRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSYLLLIPTATIITVPFLIKLL 189
Cdd:cd17355 125 RRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLL 178
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
70-194 |
2.41e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 42.98 E-value: 2.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 70 GKLSDQMGIKNLLLF-GIMVNGLGSIIGFVGHSFFPILIlARFIQGIgAAAFPALVMVVVARYIPKENRGKAFGLIGSLV 148
Cdd:cd17490 52 GILSDRIGKRKLFIIiGLLFTVLASLIMILFPSPWGLLI-ARFLSGI-AAATWVSFTVLYASYFPPDEAAKAMGLINLVN 129
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1827977908 149 AMGEGVGPAIGGMVAHYIHWSYLLLIpTATIITVPFLIKLLKKEER 194
Cdd:cd17490 130 NLGQLIAFLIGGLIAEHFGMRAPFLL-AALAGVLGFILSLFIKEER 174
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
6-194 |
2.85e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 42.92 E-value: 2.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 6 SQSTLRHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEFNKLPAS-ANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLF 84
Cdd:COG0738 202 SLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEAtAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 85 GIMVNGLGSIIGFVGHSFFPILILArFIQGIGAAAFPALVMVVVARYIPKeNRGKAFGLIGSLVAMGEGVGPAIGGMVAH 164
Cdd:COG0738 282 SALLAAVGLLLALLAPGPWLALIGL-ALVGLGLSLMFPTIFSLALDGLGK-RTAAAVSAVLIMGIVGGAIGPPLIGFLAD 359
|
170 180 190
....*....|....*....|....*....|
gi 1827977908 165 YIHWSYLLLIPTATIITVPFLIKLLKKEER 194
Cdd:COG0738 360 AFGLRAAFLVPLVCYLLILLLALALKRKRR 389
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
70-160 |
3.34e-04 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 42.56 E-value: 3.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 70 GKLSDQMGIKNLLLFGIMVNGLGSIIGFVGHSFFpILILARFIQGIGAAAFPALVMVVVARYIPKEN-RGKAFGLIGSLV 148
Cdd:cd17384 52 GPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYG-VLFLARALQGVGSACSSVAGMGMLASLYPDDKeRGKAMGIALGGL 130
|
90
....*....|..
gi 1827977908 149 AMGEGVGPAIGG 160
Cdd:cd17384 131 ALGVLVGPPFGG 142
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
56-391 |
3.47e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.55 E-value: 3.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 56 TAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGFVGHSFfPILILARFIQGIGAAAFPALVMVVVARYIPKE 135
Cdd:cd17477 38 SAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSP-WVWFLLRFVMGIGLAGLFVVSESWLNALATNE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 136 NRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSYLLliptatiitvpflikllkkeerirghidMAGIILMSAGIVFFM 215
Cdd:cd17477 117 NRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLI----------------------------AAVLLLLALVPLLLT 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 216 LFTTSYRFSFLIISILAFFIFVKHIrkaqdpfvdpelgknvffVIGTLCGGLIFGTaagFVSMVP-YMMKdvHHLSTTAI 294
Cdd:cd17477 169 RRAAPEIEEAESISLRRLLRIAPLA------------------LLGAFVAGFLEGA---FYSLLPlYGLR--LGLSVAQA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 295 GsgiIFPGTMSV--IIFGYIGGLLVDRKGSLYVLtIGSALLSSGFLIAAFFIDAAPWIMtIIVIFVFGGLSFT-KTVIST 371
Cdd:cd17477 226 A---LLLAAFVLggLLLQWPLGWLADRFDRRRVL-LGCALLGALAALLLPLVPGLPLAL-LVLLFLWGGAAGPlYTLALA 300
|
330 340
....*....|....*....|
gi 1827977908 372 VVSSGLKEKEAGAGMSLLNF 391
Cdd:cd17477 301 LAGDRLPGDELVAANAALLL 320
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
6-197 |
6.87e-04 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 41.74 E-value: 6.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 6 SQSTLRHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTAL---YGKLSDQMGIKNLL 82
Cdd:PRK15403 5 PRFFARHAATLFFPMALILYDFAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALqwlLGPLSDRIGRRPVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 83 LFGIMVNGLGSIIGFVGHSFFPILIlARFIQGIgAAAFPALVMVVVARYIPKENRG-KAFGLIGSLVAMGEGVGPAIGGM 161
Cdd:PRK15403 85 ITGALIFTLACAATLFTTSMTQFLI-ARFIQGT-SICFIATVGYVTVQEAFGQTKGiKLMAIITSIVLVAPIIGPLSGAA 162
|
170 180 190
....*....|....*....|....*....|....*.
gi 1827977908 162 VAHYIHWSYLLLIPTATIITVPFLIKLLKKEERIRG 197
Cdd:PRK15403 163 LMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKRG 198
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
32-170 |
7.93e-04 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 41.89 E-value: 7.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 32 VLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSII-GFV-GHSFFpilILA 109
Cdd:TIGR01299 185 VVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFsSFVqGYGFF---LFC 261
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1827977908 110 RFIQGIGAAAFPALVMVVVARYIPKENRGK------AFGLIGSLVAmgEGVGPAIggmVAHYiHWSY 170
Cdd:TIGR01299 262 RLLSGFGIGGAIPIVFSYFAEFLAQEKRGEhlswlcMFWMIGGIYA--AAMAWAI---IPHY-GWSF 322
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
8-180 |
8.95e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 41.26 E-value: 8.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 8 STLRHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEFNKL-PASANWVNTAFMLTFSIGTALYGKLSD-QMGIKNLLLFG 85
Cdd:cd06174 197 KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLsVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIG 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 86 IMVNGLGSIIGFVGhSFFPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMV-AH 164
Cdd:cd06174 277 LLLMALGLALLLLA-PSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAA 355
|
170
....*....|....*.
gi 1827977908 165 YIHWSYLLLIPTATII 180
Cdd:cd06174 356 TFGLTGAFLVLAVLLL 371
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
15-189 |
9.79e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 41.40 E-value: 9.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 15 VLIWLCVLSFFSVLnemvlnVSLPDIANEFNKLPASAN-WVNTAFMLTFSIGTALYGKLSDQ-MGIKNLLLFGIMVNGLG 92
Cdd:cd17474 205 VSAFLYFFLYFAFL------TYLPFLLELLYGISPIIIgLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALS 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 93 SIIGFVGHSFfPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSYLL 172
Cdd:cd17474 279 LLLLGFVPSL-ALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPF 357
|
170
....*....|....*..
gi 1827977908 173 LIPTATIITVPFLIKLL 189
Cdd:cd17474 358 LVGAAIALAAAVLLALL 374
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
53-219 |
1.43e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 40.71 E-value: 1.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 53 WVNTAFMLTF---SIGTALYGKLSDQMGIKNLLLFGIMVNGLG-SIIGFVGHSFfpILILARFIQGIGAAAFPAlVMVVV 128
Cdd:cd17391 37 WSGLAFSSTFlvsAIFSPIWGRLADRYGRKPMLLRASLGMAIViGLMAFVTNVW--QLLILRLLQGVFSGYVPN-ATALI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 129 ARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSYLLLIPTATIITVPFLIKLLKKEE----RIRGHIDMAGI 204
Cdd:cd17391 114 ASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDfkpvEKKKMVSTKEV 193
|
170
....*....|....*..
gi 1827977908 205 I--LMSAGIVFFMLFTT 219
Cdd:cd17391 194 WnsVPNPSLLISLFVTT 210
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
10-156 |
1.43e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.48 E-value: 1.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 10 LRHNQVLIWLCVLSFFSVLNeMVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVN 89
Cdd:pfam07690 197 LLRDPVLWLLLALLLFGFAF-FGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLL 275
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1827977908 90 GLGSIIGFVGHSFF--PILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGP 156
Cdd:pfam07690 276 ILAALGLLLLSLTLssLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
58-160 |
1.83e-03 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 40.28 E-value: 1.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 58 FMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSII-GFVGHS-----FFPILILARFIQGIGAAAFPALVMVVVARY 131
Cdd:cd17385 43 FALVIFLTSPIFGKYLVKIGAKFMFVAGMFVSGGCTILfGFLDRVpdgtvFIALCFLVRIVEAVGFAAFITASFAIIAKE 122
|
90 100
....*....|....*....|....*....
gi 1827977908 132 IPkENRGKAFGLIGSLVAMGEGVGPAIGG 160
Cdd:cd17385 123 FP-NNIATVLGTLETFSGLGLMLGPPLGG 150
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
54-176 |
2.12e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 40.32 E-value: 2.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 54 VNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGFVGHS--FFPILILARFIQGIGAAAFPALVMVVVARY 131
Cdd:cd17357 54 IVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSakSPELLIFGRFLVGIACGLSTGFVPMYLQEI 133
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1827977908 132 IPKENRgkafGLIGSLVAMGEGVGPAIGGMVAH-YI-----HWSYLLLIPT 176
Cdd:cd17357 134 SPSELR----GALGSLTQIGVTLGILLGQVFGLpSVlgtetLWPYLLFFPG 180
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
64-168 |
2.21e-03 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 40.31 E-value: 2.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 64 IGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGFVGHSFFPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGL 143
Cdd:cd17356 60 FGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSL 139
|
90 100
....*....|....*....|....*
gi 1827977908 144 IGSLVamgegvgpAIGGMVAHYIHW 168
Cdd:cd17356 140 YQLAI--------TIGILVAYCINY 156
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
34-166 |
2.34e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 39.90 E-value: 2.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 34 NVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGFVGHSFFPILILARFIQ 113
Cdd:cd17353 23 SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLG 102
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1827977908 114 GIGAAAFPALVMVVVARYIPkENRgkafGLIGSLVAMGEGVGPAIGGMVAHYI 166
Cdd:cd17353 103 GIGAGIGYITPVSTAVKWFP-DKR----GLATGIVIAGFGLGSLIFSPLIAYL 150
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
31-219 |
3.07e-03 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 39.80 E-value: 3.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 31 MVLNVSLPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGFVGHSFFPILILaR 110
Cdd:cd17441 16 MILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVL-R 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 111 FIQGIGAAAFPALVmVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSYLLLIPTATIITVPFLIKLLK 190
Cdd:cd17441 95 GLVGFGIGGVPQSV-TLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSALPLLIFAVLCFWLP 173
|
170 180 190
....*....|....*....|....*....|
gi 1827977908 191 KEERIRGHIDMAGIILMSAGIVFFM-LFTT 219
Cdd:cd17441 174 ESARYWTTILLWFIWFSNAFSYYGLvLLTT 203
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
32-139 |
3.26e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 39.48 E-value: 3.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 32 VLNVSLPDIANEFN--KLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGFVGHSFfPILILA 109
Cdd:cd17315 15 VINGALLYIAKDLGfgLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNV-WVLIVG 93
|
90 100 110
....*....|....*....|....*....|
gi 1827977908 110 RFIQGIGAAAFPALVMVVVARYIPKENRGK 139
Cdd:cd17315 94 RFLLGLGVGLASVLVPLYISEIAPAKIRGA 123
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
16-186 |
3.79e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.48 E-value: 3.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 16 LIWLCVLSFFSVLNEMVLNVSLPDIANEFNKLPASanwVNTAFMLTFSIGTA-----LYGKLSDQMGIKNLLLFGIMVNG 90
Cdd:cd17330 176 LRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPS---QIGLLLALVGIAGIlaqllLIPRLAKRLGERKLLRLGLLLAI 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 91 LG-SIIGFVghSFFPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGG-MVAHYIHW 168
Cdd:cd17330 253 IGlLLLPFA--SSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGpLYSFLGPG 330
|
170
....*....|....*...
gi 1827977908 169 SYLLLipTATIITVPFLI 186
Cdd:cd17330 331 VPFLL--AAGLLLIALFL 346
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
263-412 |
5.41e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.75 E-value: 5.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 263 LCGGLIFGTAAGFVsmVPYM---MKDVHHLSTTAIGSgIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLSSGFLI 339
Cdd:cd17329 5 LIGSFLNRLGFFMV--WPFMaiyLHQQLGLSASIVGL-VLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFAL 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1827977908 340 AAFFIDAAPWIMTIIVIFVFGGLSFtkTVISTVVSSGLKEKEAGAGMSLLNFTSFLSEGTGIAIVGGLLSIGF 412
Cdd:cd17329 82 LGFAHSPWLFAIALVLTGFGGGLFE--PASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF 152
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
32-216 |
5.80e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 39.27 E-value: 5.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 32 VLNVSLPDIANEFNKLPASANwvNTAFMLTFSIGTA----LYGKLSDQMGIKNLLLFGIMVNGLGSIIGFVGHSFFPILI 107
Cdd:pfam06609 59 VLQASASALPNILQDIGQSEN--QGLFSTLWTMGQAvsilMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLA 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 108 LARFIqgiGAAAFPALVMVVVARYIpKENRGKAFGL--IGSLVAMGEGVGPAIGGMVAHYIHWS---YLLLIPTATIITV 182
Cdd:pfam06609 137 AMTLL---GVAAGPAGASPLFIGEL-MSNKTKFLGLliVSAPTIAMNGAGPYFGQRLAIQGNWRwifYIYIIMSAIAVLL 212
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1827977908 183 -------PFLIKLLKKEERIR---GHIDMAGIILMSAGIVFFML 216
Cdd:pfam06609 213 iiiwyhpPSFAQLHGKKARKRdelAKLDWIGIFLVIAGTSLFLL 256
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
37-189 |
5.91e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 38.82 E-value: 5.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 37 LPDIANEFNKLPASANWVNTAFMLTFSIGTALYGKLSDQMGIKNLLLFGIMVNGLGSIIGFVGHSFFpILILARFIQGIG 116
Cdd:cd06180 219 LPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPA-GLVLSAVLFGGT 297
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1827977908 117 AAAFPALVMVVvARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSYLLLIPTATIITVPFLIKLL 189
Cdd:cd06180 298 FMAITALVMAL-ARELAPPAAPRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAALLALL 369
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
56-186 |
6.08e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 38.68 E-value: 6.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 56 TAFMLTFSIGTALY-GKLSDQ-MGIKNLLLFGIMVNGLGSIIGFVGHSFFPILILARFIQGIGAAAFPALVMVV--VARY 131
Cdd:cd17471 38 MTLSALSGIVVSQWlGRLSDRgGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAAFPQLFALAreYADR 117
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1827977908 132 IPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSYLLLIpTATIITVPFLI 186
Cdd:cd17471 118 SSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLL-AALLYLVVALL 171
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
68-359 |
6.57e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 38.44 E-value: 6.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 68 LYGKLSDQMGIKNLLLFGIMVNGLGSII-GFVGHSFFPILILARFIqGIGAAAFpALVMVVVARYIPKENRGKAFGLIGS 146
Cdd:TIGR00886 56 ILGFLVDIFGPRYTTALSLLLLAIPCLWaGLAVQSYSVLLLIRLFI-GIAGGSF-ASCMPWISFFFPKKIQGTALGLAAG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 147 LVAMGEG----VGPAI------GGMVAHYIHWSYLLLIPTATIITVPFLIkllkkeerirghidmagiilmsagIVFFML 216
Cdd:TIGR00886 134 WGNMGGGvaqfVMPPIigslifGGGQPAHLAWGWAFVIVPAGILLLPALL------------------------IFFVGA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 217 FTTSYRFSFLIISILAFFIFVKHIRKAqdpfvdpelgknvffvIGTLCGGLIFGTAAGFVSMVPYMMKDVHHLSTTAIGS 296
Cdd:TIGR00886 190 DTPPGKPATGKLSFKEALKVFGNRHTW----------------ILALLYSVTFGSFLGVSSIFAMLFKDQFGLSKVQAGA 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1827977908 297 -GIIFPGTMSViiFGYIGGLLVDRKGSLYVLTIGSALLSSGFLIAAFFIDAAPWIMTIIVIFVF 359
Cdd:TIGR00886 254 yASLGGFLGSL--ARPAGGAISDRLGGARKLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVLFVA 315
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
35-194 |
7.52e-03 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 38.46 E-value: 7.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 35 VSLPDIANEFNklpASANWVNTAFMLtFSIGTA----LYGKLSDQMGIKNLLLFGIMVNGLGSIIGFVGHSFFPILIlAR 110
Cdd:PRK10473 24 VGLPRIAADLN---ASEAQLHIAFSV-YLAGMAaamlFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLA-GR 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 111 FIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGGMVAHYIHWSYLLLIPTATIITVPFLIKLLK 190
Cdd:PRK10473 99 FLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFIL 178
|
....
gi 1827977908 191 KEER 194
Cdd:PRK10473 179 KETR 182
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
60-185 |
9.14e-03 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 38.37 E-value: 9.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977908 60 LTFSIGTALYGKLSDQMGIKNLLLFGIMVNG-LGSIIGFV-GHSFFpilILARFIQGIGAAAFPALVMVVVARYIPKENR 137
Cdd:cd17438 45 LGMMAGAFIWGGLADKLGRKRCLIISLAINAsFAFLSSFVqGYGAF---LFCRLISGFGIGGSLPIVFAYFSEFLAREKR 121
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827977908 138 GK------AFGLIGSLVA--MGEGVGPAIG-----GMVAHYIHWSYLLLI----PTATIITVPFL 185
Cdd:cd17438 122 GEhlswlcMFWMIGGLYAsaMAWSIIPHYGwgfsmGTNYHFHSWRVFVIIcalpCIASIIALKFM 186
|
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