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Conserved domains on  [gi|1827977914|ref|WP_167408619|]
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YidC family membrane integrase SpoIIIJ [Bacillus subtilis]

Protein Classification

YidC/Oxa1 family membrane protein insertase( domain architecture ID 10011875)

YidC/Oxa1 family membrane protein insertase functions as a membrane protein chaperone and as an independent insertase for membrane proteins, such as Bacillus subtilis membrane protein insertase MisCA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK02944 PRK02944
YidC family membrane integrase SpoIIIJ;
3-261 2.36e-152

YidC family membrane integrase SpoIIIJ;


:

Pssm-ID: 179508  Cd Length: 255  Bit Score: 424.57  E-value: 2.36e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914   3 LKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVYPLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIK 82
Cdd:PRK02944    1 MKKKLGLLAMVVALMAILAGCSEVNQPITPKSTGFWNEYFVYPLSQLITYFANLFGSNYGLAIIVVTLLIRLLILPLMIK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  83 QLRSSKAMQALQPEMQKLKEKYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEHSF 162
Cdd:PRK02944   81 QTKSTKAMQALQPEMQKLKEKYSSKDQATQQKLQQEMMQLFQKNGVNPLAGCLPIFIQMPILIAFYHAIMRTSEISKHSF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 163 LWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAINFPAALSLYWVVGNLFMIAQTFLI 242
Cdd:PRK02944  161 LWFDLGQADPYYILPIVAGITTFIQQKLMMAGTAGQNPQMAMMLWLMPIMILIFAINFPAALSLYWVVGNIFMIAQTYLI 240

                         250
                  ....*....|....*....
gi 1827977914 243 KGPDIKKNpelqKAGGKKK 261
Cdd:PRK02944  241 KGPEIKAS----KAGGSKK 255
 
Name Accession Description Interval E-value
PRK02944 PRK02944
YidC family membrane integrase SpoIIIJ;
3-261 2.36e-152

YidC family membrane integrase SpoIIIJ;


Pssm-ID: 179508  Cd Length: 255  Bit Score: 424.57  E-value: 2.36e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914   3 LKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVYPLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIK 82
Cdd:PRK02944    1 MKKKLGLLAMVVALMAILAGCSEVNQPITPKSTGFWNEYFVYPLSQLITYFANLFGSNYGLAIIVVTLLIRLLILPLMIK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  83 QLRSSKAMQALQPEMQKLKEKYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEHSF 162
Cdd:PRK02944   81 QTKSTKAMQALQPEMQKLKEKYSSKDQATQQKLQQEMMQLFQKNGVNPLAGCLPIFIQMPILIAFYHAIMRTSEISKHSF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 163 LWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAINFPAALSLYWVVGNLFMIAQTFLI 242
Cdd:PRK02944  161 LWFDLGQADPYYILPIVAGITTFIQQKLMMAGTAGQNPQMAMMLWLMPIMILIFAINFPAALSLYWVVGNIFMIAQTYLI 240

                         250
                  ....*....|....*....
gi 1827977914 243 KGPDIKKNpelqKAGGKKK 261
Cdd:PRK02944  241 KGPEIKAS----KAGGSKK 255
5TM_YidC_Alb3 cd20070
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ...
 82-243 8.50e-79

Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410994 [Multi-domain]  Cd Length: 181  Bit Score: 235.35  E-value: 8.50e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  82 KQLRSSKAMQALQPEMQKLKEKYSSKdqktQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEHS 161
Cdd:cd20070    21 KQYKSMKKMQELQPKIKEIQEKYKDD----KQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFIALYQVLRNSIELRGAP 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 162 FLWF--DLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAINFPAALSLYWVVGNLFMIAQT 239
Cdd:cd20070    97 FLWWilDLSAPDPYYILPILMGVTMFLQQKLTPTPTDDQAPQQKMMMYFMPVMFTFIFLSFPSGLVLYWLVSNLFSIIQQ 176


                  ....
gi 1827977914 240 FLIK 243
Cdd:cd20070   177 LIIN 180
YidC COG0706
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
35-243 5.66e-76

Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440470 [Multi-domain]  Cd Length: 212  Bit Score: 229.62  E-value: 5.66e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  35 PHFWDKYVVYPLSELITYVAKLTGdNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKEKYsskdQKTQQK 114
Cdd:COG0706     2 DYGWFGFIAKPLFWLLNFLHSLVG-NWGLAIILLTLIVRLLLFPLTVKQYKSMAKMQELQPELKEIQEKY----KDDPQK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 115 LQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEHSFLWF-DLGEKDPYYI-LPIVAGVATFVQQKLMM 192
Cdd:COG0706    77 LQQEMMKLYKEEGVNPLGGCLPMLIQMPIFIALYRVLRNSIELRHAPFLGIpDLSAPDPYYIfLPILMGVTMFLQQKLNP 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1827977914 193 AgnAQQNPQMAMMLWIMPIMIIVFAINFPAALSLYWVVGNLFMIAQTFLIK 243
Cdd:COG0706   157 A--PAQDPQQKKMMYIMPLMFLFFFLSFPAGLVLYWVVSNLLTIGQQLIIN 205
yidC_oxa1_cterm TIGR03592
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes ...
 82-242 1.35e-72

membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes full-length from some species, and the C-terminal region only from other species, of the YidC/Oxa1 family of proteins. This domain appears to be univeral among bacteria (although absent from Archaea). The well-characterized YidC protein from Escherichia coli and its close homologs contain a large N-terminal periplasmic domain in addition to the region modeled here. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274665 [Multi-domain]  Cd Length: 179  Bit Score: 219.66  E-value: 1.35e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  82 KQLRSSKAMQALQPEMQKLKEKYSSKdqktQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEHS 161
Cdd:TIGR03592  23 KQYKSMRKMQELQPKLKEIQEKYKED----PQKLQQEMMKLYKEEGVNPLGGCLPLLIQMPIFIALYQVLLRSIELRHAP 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 162 FLW-FDLGEKDPYYILPIVAGVATFVQQKLMMAGNaQQNPQMAMMLWIMPIMIIVFAINFPAALSLYWVVGNLFMIAQTF 240
Cdd:TIGR03592  99 FLWiIDLSSPDPYYILPILMGVTMFLQQKLSPKGP-PDPAQQKMMMYFMPLMFLFFFLSFPAGLVLYWVVSNLFTIIQQL 177


                  ..
gi 1827977914 241 LI 242
Cdd:TIGR03592 178 II 179
60KD_IMP pfam02096
60Kd inner membrane protein;
82-243 4.41e-71

60Kd inner membrane protein;


Pssm-ID: 460443 [Multi-domain]  Cd Length: 187  Bit Score: 216.18  E-value: 4.41e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  82 KQLRSSKAMQALQPEMQKLKEKYSskdqKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISE-H 160
Cdd:pfam02096  22 KQYKSMAKMQELQPEMKEIQEKYK----DDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIFIALYRVLRNSIELRHaP 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 161 SFLWF-DLGEKDP-----YYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAINFPAALSLYWVVGNLF 234
Cdd:pfam02096  98 FFLWIaDLSAPDPisilhYYILPILMGVTMFLQQKLTPAPQDQPPQMKMMMLYFMPLMFLFFFLNFPAGLVLYWVVSNLL 177


                  ....*....
gi 1827977914 235 MIAQTFLIK 243
Cdd:pfam02096 178 SIGQQLIIN 186
 
Name Accession Description Interval E-value
PRK02944 PRK02944
YidC family membrane integrase SpoIIIJ;
3-261 2.36e-152

YidC family membrane integrase SpoIIIJ;


Pssm-ID: 179508  Cd Length: 255  Bit Score: 424.57  E-value: 2.36e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914   3 LKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVYPLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIK 82
Cdd:PRK02944    1 MKKKLGLLAMVVALMAILAGCSEVNQPITPKSTGFWNEYFVYPLSQLITYFANLFGSNYGLAIIVVTLLIRLLILPLMIK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  83 QLRSSKAMQALQPEMQKLKEKYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEHSF 162
Cdd:PRK02944   81 QTKSTKAMQALQPEMQKLKEKYSSKDQATQQKLQQEMMQLFQKNGVNPLAGCLPIFIQMPILIAFYHAIMRTSEISKHSF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 163 LWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAINFPAALSLYWVVGNLFMIAQTFLI 242
Cdd:PRK02944  161 LWFDLGQADPYYILPIVAGITTFIQQKLMMAGTAGQNPQMAMMLWLMPIMILIFAINFPAALSLYWVVGNIFMIAQTYLI 240

                         250
                  ....*....|....*....
gi 1827977914 243 KGPDIKKNpelqKAGGKKK 261
Cdd:PRK02944  241 KGPEIKAS----KAGGSKK 255
5TM_YidC_Alb3 cd20070
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ...
 82-243 8.50e-79

Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410994 [Multi-domain]  Cd Length: 181  Bit Score: 235.35  E-value: 8.50e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  82 KQLRSSKAMQALQPEMQKLKEKYSSKdqktQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEHS 161
Cdd:cd20070    21 KQYKSMKKMQELQPKIKEIQEKYKDD----KQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFIALYQVLRNSIELRGAP 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 162 FLWF--DLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAINFPAALSLYWVVGNLFMIAQT 239
Cdd:cd20070    97 FLWWilDLSAPDPYYILPILMGVTMFLQQKLTPTPTDDQAPQQKMMMYFMPVMFTFIFLSFPSGLVLYWLVSNLFSIIQQ 176


                  ....
gi 1827977914 240 FLIK 243
Cdd:cd20070   177 LIIN 180
YidC COG0706
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
35-243 5.66e-76

Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440470 [Multi-domain]  Cd Length: 212  Bit Score: 229.62  E-value: 5.66e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  35 PHFWDKYVVYPLSELITYVAKLTGdNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKEKYsskdQKTQQK 114
Cdd:COG0706     2 DYGWFGFIAKPLFWLLNFLHSLVG-NWGLAIILLTLIVRLLLFPLTVKQYKSMAKMQELQPELKEIQEKY----KDDPQK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 115 LQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEHSFLWF-DLGEKDPYYI-LPIVAGVATFVQQKLMM 192
Cdd:COG0706    77 LQQEMMKLYKEEGVNPLGGCLPMLIQMPIFIALYRVLRNSIELRHAPFLGIpDLSAPDPYYIfLPILMGVTMFLQQKLNP 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1827977914 193 AgnAQQNPQMAMMLWIMPIMIIVFAINFPAALSLYWVVGNLFMIAQTFLIK 243
Cdd:COG0706   157 A--PAQDPQQKKMMYIMPLMFLFFFLSFPAGLVLYWVVSNLLTIGQQLIIN 205
yidC_oxa1_cterm TIGR03592
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes ...
 82-242 1.35e-72

membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes full-length from some species, and the C-terminal region only from other species, of the YidC/Oxa1 family of proteins. This domain appears to be univeral among bacteria (although absent from Archaea). The well-characterized YidC protein from Escherichia coli and its close homologs contain a large N-terminal periplasmic domain in addition to the region modeled here. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274665 [Multi-domain]  Cd Length: 179  Bit Score: 219.66  E-value: 1.35e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  82 KQLRSSKAMQALQPEMQKLKEKYSSKdqktQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEHS 161
Cdd:TIGR03592  23 KQYKSMRKMQELQPKLKEIQEKYKED----PQKLQQEMMKLYKEEGVNPLGGCLPLLIQMPIFIALYQVLLRSIELRHAP 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 162 FLW-FDLGEKDPYYILPIVAGVATFVQQKLMMAGNaQQNPQMAMMLWIMPIMIIVFAINFPAALSLYWVVGNLFMIAQTF 240
Cdd:TIGR03592  99 FLWiIDLSSPDPYYILPILMGVTMFLQQKLSPKGP-PDPAQQKMMMYFMPLMFLFFFLSFPAGLVLYWVVSNLFTIIQQL 177


                  ..
gi 1827977914 241 LI 242
Cdd:TIGR03592 178 II 179
60KD_IMP pfam02096
60Kd inner membrane protein;
82-243 4.41e-71

60Kd inner membrane protein;


Pssm-ID: 460443 [Multi-domain]  Cd Length: 187  Bit Score: 216.18  E-value: 4.41e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  82 KQLRSSKAMQALQPEMQKLKEKYSskdqKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISE-H 160
Cdd:pfam02096  22 KQYKSMAKMQELQPEMKEIQEKYK----DDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIFIALYRVLRNSIELRHaP 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 161 SFLWF-DLGEKDP-----YYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAINFPAALSLYWVVGNLF 234
Cdd:pfam02096  98 FFLWIaDLSAPDPisilhYYILPILMGVTMFLQQKLTPAPQDQPPQMKMMMLYFMPLMFLFFFLNFPAGLVLYWVVSNLL 177


                  ....*....
gi 1827977914 235 MIAQTFLIK 243
Cdd:pfam02096 178 SIGQQLIIN 186
PRK01622 PRK01622
membrane protein insertase YidC;
1-243 8.94e-67

membrane protein insertase YidC;


Pssm-ID: 179310  Cd Length: 256  Bit Score: 207.68  E-value: 8.94e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914   1 MLLKRRIGLLLSMVGVFMLLAGCSSVKePITADSPHFWDKYVVYPLSELITYVAKLTGDNYGLSIILVTILIRLLILPLM 80
Cdd:PRK01622    1 MLKSYRAVLVSLSLLLVLVLSGCSNAA-PIDAHSDGFFDHYFVYPFSFLIQFVAHHIGGSYGIAIIIVTLIIRSLMIPLA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  81 IKQLRSSKAMQA----LQPEMQKLKEKYS-SKDQKTQQKLQQETMALFQKHGVNPLA-GCFPILIQMPILIGFYHAIMRT 154
Cdd:PRK01622   80 VSQYKSQRGMQEkmavMKPELDKIQAKLKvTKDLEKQKEYQKEMMELYKSGNINPLAmGCLPLLIQMPILSAFYYAIRRT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 155 QAISEHSFLWFDLGEKDpyYILPIVAGVATFVQQKLMMagNAQQNP----QMAMMLWIMPIMIIVFAINFPAALSLYWVV 230
Cdd:PRK01622  160 EEIASHSFLWFNLGHAD--HILPIIAGLTYFIQMKVSQ--SNGTSPeqvqMLKIQGIMMPAMILFMSFAAPSALVLYWIT 235

                         250
                  ....*....|...
gi 1827977914 231 GNLFMIAQTFLIK 243
Cdd:PRK01622  236 GGLFLMGQTIVLR 248
PRK00145 PRK00145
putative inner membrane protein translocase component YidC; Provisional
 82-256 8.13e-55

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 234665 [Multi-domain]  Cd Length: 223  Bit Score: 176.08  E-value: 8.13e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  82 KQLRSSKAMQALQPEMQKLKEKYsskdQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEHS 161
Cdd:PRK00145   52 KQTKSSLRMNEIQPEIKKLQAKY----KNDPQKLQQEMMKLYKEKGVNPLGGCLPLLIQWPILIALYYVFNNLTGINGVS 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 162 FLWF-DLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAINFPAALSLYWVVGNLFMIAQTF 240
Cdd:PRK00145  128 FLWIkDLAKPDITWILPILSGATTYLSGYLMTKADSSQAGQMKTMNIGMSIFMGVMSWKFKSALVLYWVIGNLIQIIQTY 207

                         170
                  ....*....|....*.
gi 1827977914 241 LIKGPDIKKNPELQKA 256
Cdd:PRK00145  208 FIKKLELKKKVEAKAA 223
PRK01318 PRK01318
membrane protein insertase; Provisional
 82-243 4.96e-52

membrane protein insertase; Provisional


Pssm-ID: 234942 [Multi-domain]  Cd Length: 521  Bit Score: 176.99  E-value: 4.96e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  82 KQLRSSKAMQALQPEMQKLKEKYssKDQKtqQKLQQETMALFQKHGVNPLAGCFPILIQMPILIG----FYHAI-MRtqa 156
Cdd:PRK01318  344 KSYVSMAKMKVLQPKMQELKEKY--KDDP--QKMQQEMMELYKKEKVNPLGGCLPILIQIPIFFAlykvLLVSIeLR--- 416

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 157 iseHS--FLWF-DLGEKDPYYIL-----PIVAGVATFVQQKLMMagnAQQNPQMAMMLWIMPIMIIVFAINFPAALSLYW 228
Cdd:PRK01318  417 ---HApfIGWIhDLSAPDPYFILhigllPILMGITMFLQQKLNP---TPTDPMQAKIMKFMPLIFTFFFLSFPAGLVLYW 490

                         170
                  ....*....|....*
gi 1827977914 229 VVGNLFMIAQTFLIK 243
Cdd:PRK01318  491 IVNNLLTIIQQYLIN 505
5TM_YidC_Oxa1_Alb3 cd19751
Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1 ...
 82-243 1.72e-51

Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1/Alb3 protein family of insertases facilitate the insertion, folding and assembly of proteins of the inner membranes of bacteria and mitochondria, and the thylakoid membrane of plastids. Members include bacterial YidC, mitochondrial Cox18 and Oxa1, and chloroplastic Alb3 and Alb4. Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Oxa1 and Cox18/Oxa2 mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Alb3 and Alb3-like proteins, including Alb4, are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410992 [Multi-domain]  Cd Length: 189  Bit Score: 166.58  E-value: 1.72e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  82 KQLRSSKAMQALQPEMQKLKEKYSSK--DQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISE 159
Cdd:cd19751    21 KQQKSMRKMQVIRPEMEAIREKYKEKasKDKVQQEMQKEMLGLYKKHGVNPMAGCLPLFIQLPIFMAFYFAIMRTEEIRY 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 160 HSFLWF-DLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNP---QMAMMLWIMPIMIIVFAINFPAALSLYWVVGNLFM 235
Cdd:cd19751   101 HTFLWFfDLGQPDYLYILPFVAGITTYFQFKMTMSHQQQMQMmqmQMKVMLYVMPVMIIIAGLSFPSALSLYWIISNLFM 180


                  ....*...
gi 1827977914 236 IAQTFLIK 243
Cdd:cd19751   181 IIQTYFIV 188
5TM_Oxa1-like cd20069
Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar ...
 79-245 2.45e-40

Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar proteins; This group is composed mostly of the mitochondrial members of the YidC/Oxa1/Alb3 protein family of insertases, including mitochondrial inner membrane proteins Oxa1, Oxa1-like (Oxa1L), cytochrome c oxidase assembly protein 18 (Cox18, also called Oxa2), and Arabidopsis thaliana mitochondrial ALBINO3-like protein 3 (ALB33). It also includes Arabidopsis thaliana chloroplastic ALBINO3-like protein 2 (ALB32). Members of this group mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Oxa1 and Cox18/Oxa2 are essential for the activity and assembly of cytochrome c oxidase, playing central roles in the translocation and export of the N-terminal and C-terminal parts, respectively, of the COX2 protein into the mitochondrial intermembrane space. ALB32 may be involved in the insertion of integral membrane proteins into the chloroplast thylakoid membranes. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410993 [Multi-domain]  Cd Length: 201  Bit Score: 138.04  E-value: 2.45e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  79 LMIKQLRSSKAMQALQPEMQKLKEKYS----SKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRT 154
Cdd:cd20069    22 LVIKSQRNAARMANLQPELQKLQEKLKearaSGDQLEAAEARKELKELMKKHNVNPLKSLLLPLVQAPVFISFFFALRKM 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 155 QAISEHSF-----LWF-DLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIM---PIMIIVFAINFPAALS 225
Cdd:cd20069   102 ANLPVPSFktgglLWFtDLTVPDPYYILPILTSLTFLATIELGAETGTSGSPQSKTMKNVFrglPVLMIPFTANFPSAVF 181

                         170       180
                  ....*....|....*....|
gi 1827977914 226 LYWVVGNLFMIAQTFLIKGP 245
Cdd:cd20069   182 LYWITSNLFSLAQNLLLRIP 201
PRK02463 PRK02463
OxaA-like protein precursor; Provisional
 1-249 3.16e-39

OxaA-like protein precursor; Provisional


Pssm-ID: 235040  Cd Length: 307  Bit Score: 138.32  E-value: 3.16e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914   1 MLLKRRI---GLLLSMVgvfMLLAGCSSVKEpitADSPHFWD-KYVVYPLSELITYVAKLTGDNYGLSIILVTILIRLLI 76
Cdd:PRK02463    2 KKTLKRIlfsGLALSML---LTLTGCVGRDK---HGNPTGFIwNFLGAPMSYFIDYFANNLGLGFGLAIIIVTIIVRLII 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  77 LPLMIKQLRS----SKAMQALQPEMQKLKEKYssKDQKTQQ-KL--QQETMALFQKHGVNPLA--GCFPILIQMPILIGF 147
Cdd:PRK02463   76 LPLGLYQSWKatyqSEKMAYLKPVFEPINERL--KNATTQEeKMaaQTELMAAQRENGISMLGgiGCLPLLIQMPFFSAL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 148 YHAIMRTQAISEHSFLWFDLGEKDpyYILPIVAGVATFVQQKL-MMAGNAQQNPQMAMMLWIMPIMIIVFAINFPAALSL 226
Cdd:PRK02463  154 YFAAQYTKGVSTSTFLGIDLGSPS--LVLTAIIGVLYFFQSWLsMMGVPEEQREQMKAMMYMMPIMMVVFSFSSPAGVGL 231

                         250       260
                  ....*....|....*....|....*..
gi 1827977914 227 YWVVGNLFMIAQ----TFLIKgPDIKK 249
Cdd:PRK02463  232 YWLVGGFFSIIQqlitTYILK-PRLRK 257
PRK03449 PRK03449
putative inner membrane protein translocase component YidC; Provisional
 82-244 1.38e-32

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 179580  Cd Length: 304  Bit Score: 120.94  E-value: 1.38e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  82 KQLRSSKAMQALQPEMQKLKEKYSskdqKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIM---RTQ--- 155
Cdd:PRK03449   53 RQIRTTRKMQELQPQIKALQKKYG----NDRQKMALEMQKLQKEHGFNPILGCLPMLAQIPVFLGLFHVLRsfnRTGtgf 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 156 -------------------AISEHSFLWFDL-GEKDPYYI------------------------LPIVAGVATFVQQKLM 191
Cdd:PRK03449  129 gqlgmsveenrntpnyvfsAEDVQSFLDARLfGAPLSAYItmprsgldafvdftrtniilvgvpLMIIAGVATHFNSRAS 208

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 192 MAGN---AQQNPQMAMM----LWIMPIMIIVFAINFPAALSLYWVVGNLFMIAQTFLIKG 244
Cdd:PRK03449  209 VARQsaeAAANPQTAMMnklaLWVFPLGVLVGGPFLPLAILLYWVSNNIWTFGQQHYVFG 268
PRK01315 PRK01315
putative inner membrane protein translocase component YidC; Provisional
 82-251 4.00e-32

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 234941  Cd Length: 329  Bit Score: 120.23  E-value: 4.00e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  82 KQLRSSKAMQALQPEMQKLKEKYSSKdqktQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISE-H 160
Cdd:PRK01315   63 KQIKSQRNMQEIQPKMKKIQEKYKGD----RERMSQEMMKLYKETGTNPLSSCLPLLLQMPIFFALYRVLDSAASRGDgI 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 161 SFLWFDLGEK--------------------DPYYILPIVAGV-------ATFVQQKLMMAGN----AQQNPQMA---MML 206
Cdd:PRK01315  139 GPINPPLLESfrhahifgaplaatflqalnAGNTAVQVVAAVliilmsaSQFITQLQLMTKNmppeAKTGPMAQqqkMLL 218

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1827977914 207 WIMPIMIIVFAINFPAALSLYWVVGNLFMIAQTFLIkgpdIKKNP 251
Cdd:PRK01315  219 YLFPLMFLVSGIAFPVGVLFYWLTSNVWTMGQQFYV----IRNNP 259
PRK01001 PRK01001
putative inner membrane protein translocase component YidC; Provisional
 84-238 7.04e-25

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 234887 [Multi-domain]  Cd Length: 795  Bit Score: 103.34  E-value: 7.04e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  84 LRSSKAMQALQPEMQKLKEKYsskdQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEHSFL 163
Cdd:PRK01001  599 IRSMRRMQKLSPYIQEIQQKY----KKEPKRAQMEIMALYKTNKVNPITGCLPLLIQLPFLIAMFDLLKSSFLLRGASFI 674

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 164 --WFD-LGEKD--------------PYYILPIVAGVATFVQQKLMMAGNA-----QQNPQMAMmlwiMPIMIIVFAI--- 218
Cdd:PRK01001  675 pgWIDnLTAPDvlfswetpiwfignEFHLLPILLGVVMFAQQKISSLKRKgpvtdQQRQQEAM----GTMMALLFTFmfy 750

                         170       180
                  ....*....|....*....|
gi 1827977914 219 NFPAALSLYWVVGNLFMIAQ 238
Cdd:PRK01001  751 NFPSGLNIYWLSSMLLGVIQ 770
PRK02201 PRK02201
putative inner membrane protein translocase component YidC; Provisional
 82-242 1.07e-20

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 235012  Cd Length: 357  Bit Score: 89.69  E-value: 1.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  82 KQLRSSKAMQALQPEMQKLKEKYS--SKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISE 159
Cdd:PRK02201  154 KSTFNQEKQEELQGKKAKIDAKYKdyKKDKQMKQRKQQEIQELYKKHNISPFSPFVQMFVTLPIFIAVYRVVQSLPSIKV 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 160 HSFLWFDLGEKD---------PYYILPIVAGVATFVQQKL----------MMAGNAQQNPQMA---MMLWIMPIMIIVFA 217
Cdd:PRK02201  234 TTWLGIDLSATSwqeifagnwIYLPILIIVVPVQALSQLLpqilnkkknkERTLNVKEKEALKkqnKTQNIISIVFIFFG 313

                         170       180
                  ....*....|....*....|....*
gi 1827977914 218 INFPAALSLYWVVGNLFMIAQTFLI 242
Cdd:PRK02201  314 VIFAAGVQIYWIIGGIWTILQTLGI 338
PRK00247 PRK00247
putative inner membrane protein translocase component YidC; Validated
 82-242 8.71e-14

putative inner membrane protein translocase component YidC; Validated


Pssm-ID: 178945 [Multi-domain]  Cd Length: 429  Bit Score: 70.26  E-value: 8.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  82 KQLRSSKAMQALQPEMQKLKEKYSSK-DQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRT------ 154
Cdd:PRK00247   53 QQYKSGRTAAHIRPKRKALREEYKGKtDEASIRELQQKQKDLNKEYGYNPLAGCVPALIQIPVFLGLYQVLLRMarpegg 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 155 ------QAI----SEH--SFL---WFD----------------LGEKDP---YYILP--IVAGVATFVQQKLMMAGNAQQ 198
Cdd:PRK00247  133 lenpvhQPIgfltSEEveSFLqgrVFNvplpayvsmpaeqlayLGTTQAtvlAFVLPlfIAAAVFTAINMAMSTYRSFQT 212

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1827977914 199 NP-------QMAMMLWIM----PIMIIVFAIN--FPAALSLYWVVGNLFMIAQTFLI 242
Cdd:PRK00247  213 NDhdsgfavGMLKFLIVMailaPIFPLSLGLTgpFPTAIALYWVANNLWTLIQNIIM 269
PRK02654 PRK02654
putative inner membrane protein translocase component YidC; Provisional
 60-144 1.22e-12

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 235058  Cd Length: 375  Bit Score: 66.93  E-value: 1.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  60 NYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQK----LKEKYSSKDQKtqqklQQETMALFQKHGVNPLAGCF 135
Cdd:PRK02654   26 SYGLAIVALTLVIRFALYPLSAGSIRNMRRMKIAQPVMQKrqaeIQERYKNDPQK-----QQEEMGKLMKEFGNPLAGCL 100


                  ....*....
gi 1827977914 136 PILIQMPIL 144
Cdd:PRK02654  101 PLLVQMPIL 109
PRK02654 PRK02654
putative inner membrane protein translocase component YidC; Provisional
 83-242 2.16e-08

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 235058  Cd Length: 375  Bit Score: 54.22  E-value: 2.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914  83 QLRSSKAMQALQPEMQK----LKEKYSSKDQKtqqklQQETMALFQKHGVNPLAGCFPILIQMPILIGFYhAIMR----- 153
Cdd:PRK02654   49 SIRNMRRMKIAQPVMQKrqaeIQERYKNDPQK-----QQEEMGKLMKEFGNPLAGCLPLLVQMPILFALF-ATLRgspfa 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 154 ---------------------------------------------------------------------TQAISEHS--- 161
Cdd:PRK02654  123 dvnytvnlqvlpseqiaavqpqpfkskpqnifitdgvhfpviaslpggtklgvgesvkiqlqttegkpfSQLLAEYPnsk 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827977914 162 --------------------------------------------FLWFD-LGEKDPYY--------ILPIVA--GVATFV 186
Cdd:PRK02654  203 lsptwkvtkgeervkvsedgtiealapgdatiqgtipglaansgFLFIKaLGQVGFYDvdgainwdILIMVLgfGVSLYL 282

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1827977914 187 QQKLMMAGNAQqNPQMAMMLWIMPIMIIVFAINFP--AALSLYWVVGNLFMIAQTFLI 242
Cdd:PRK02654  283 SQVLSGQGMPA-NPQQSTANKITPVMFSGMFLFFPlpAGVLLYMVIANIFQTLQTFLL 339
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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