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Conserved domains on  [gi|1840536981|ref|WP_170309565|]
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lipopolysaccharide transport periplasmic protein LptA [Litorilituus lipolyticus]

Protein Classification

lipopolysaccharide transport periplasmic protein LptA( domain architecture ID 11496298)

lipopolysaccharide ABC transporter substrate-binding protein LptA plays a role in the delivery of lipopolysaccharide to the outer leaflet of the outer membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
outer_YhbN_LptA TIGR03002
lipopolysaccharide transport periplasmic protein LptA; Members of this protein family include ...
 36-178 9.24e-44

lipopolysaccharide transport periplasmic protein LptA; Members of this protein family include LptA (previously called YhbN). It was shown to be an essential protein in E. coli, implicated in cell envelope integrity, and to play a role in the delivery of LPS to the outer leaflet of the outer membrane. It works with LptB (formerly yhbG), a homolog of ABC transporter ATP-binding proteins, encoded by an adjacent gene. Numerous homologs in other Proteobacteria are found in a conserved location near lipopolysaccharide inner core biosynthesis genes. This family is related to organic solvent tolerance protein (OstA), though distantly. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Transport and binding proteins, Other]


:

Pssm-ID: 274384 [Multi-domain]  Cd Length: 142  Bit Score: 142.75  E-value: 9.24e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840536981  36 AAKKDLEQEITIKSQRQSADLKNKIASYLDDVNIQQGSISIKADIVQVFSNNKdtevEKADIYLAKGKPAIFQQQLEDGS 115
Cdd:TIGR03002   1 ALTSDREQPIHIEADSQTLDDKKGVVTFTGNVVITQGTLKIRADKVVVTRNDA----GGIEKATATGKPATFRQKLDNGK 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1840536981 116 LISLQADEIKYQPNINLITVSGNAVVKQAGSEVSGSKITYNTLNEKLEAESNSNEA--VTTILQP 178
Cdd:TIGR03002  77 EIEGQANRIEYDPAKDEVVLTGNARLKQGGNEISGDVITYDTKKQKVIAKGDGGKTgrVTTIIQP 141
 
Name Accession Description Interval E-value
outer_YhbN_LptA TIGR03002
lipopolysaccharide transport periplasmic protein LptA; Members of this protein family include ...
 36-178 9.24e-44

lipopolysaccharide transport periplasmic protein LptA; Members of this protein family include LptA (previously called YhbN). It was shown to be an essential protein in E. coli, implicated in cell envelope integrity, and to play a role in the delivery of LPS to the outer leaflet of the outer membrane. It works with LptB (formerly yhbG), a homolog of ABC transporter ATP-binding proteins, encoded by an adjacent gene. Numerous homologs in other Proteobacteria are found in a conserved location near lipopolysaccharide inner core biosynthesis genes. This family is related to organic solvent tolerance protein (OstA), though distantly. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Transport and binding proteins, Other]


Pssm-ID: 274384 [Multi-domain]  Cd Length: 142  Bit Score: 142.75  E-value: 9.24e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840536981  36 AAKKDLEQEITIKSQRQSADLKNKIASYLDDVNIQQGSISIKADIVQVFSNNKdtevEKADIYLAKGKPAIFQQQLEDGS 115
Cdd:TIGR03002   1 ALTSDREQPIHIEADSQTLDDKKGVVTFTGNVVITQGTLKIRADKVVVTRNDA----GGIEKATATGKPATFRQKLDNGK 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1840536981 116 LISLQADEIKYQPNINLITVSGNAVVKQAGSEVSGSKITYNTLNEKLEAESNSNEA--VTTILQP 178
Cdd:TIGR03002  77 EIEGQANRIEYDPAKDEVVLTGNARLKQGGNEISGDVITYDTKKQKVIAKGDGGKTgrVTTIIQP 141
LptA COG1934
Lipopolysaccharide export system protein LptA [Cell wall/membrane/envelope biogenesis];
21-178 1.38e-34

Lipopolysaccharide export system protein LptA [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441537 [Multi-domain]  Cd Length: 164  Bit Score: 120.02  E-value: 1.38e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840536981  21 LLFLASTMLFSHSTLAAKKDLEQEITIKSQRQSADLKNKIASYLDDVNIQQGSISIKADIVQVFSNnKDTEVEKADiylA 100
Cdd:COG1934     2 LLLALLLLLLAAPALAQKADRDQPIEIEADRLEVDDKKGTAVFTGNVVVTQGTLTLRADKLVVYYD-KAGGIERIE---A 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1840536981 101 KGKpAIFQQQLEDGSLISLQADEIKYQPNINLITVSGNAVVKQAGSEVSGSKITYNTLNEKLEAESNSNEA-VTTILQP 178
Cdd:COG1934    78 TGN-VTFRQKRDGGQEVEATADRAEYDVATDTVVLTGNAVLTQGGNTVTGDRITYDLKTGRATAEGGGGGGrVRAVLQP 155
PRK10894 PRK10894
lipopolysaccharide ABC transporter substrate-binding protein LptA;
22-184 2.03e-25

lipopolysaccharide ABC transporter substrate-binding protein LptA;


Pssm-ID: 182816 [Multi-domain]  Cd Length: 180  Bit Score: 97.13  E-value: 2.03e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840536981  22 LFLASTML-FSHSTLAAKKDLEQEITIKSQRQSADLKNKIASYLDDVNIQQGSISIKADIVQVFSNNKDTEVEKADIYla 100
Cdd:PRK10894    8 LLLASSLLaASIPAFALTGDTDQPIHIDSDQQSLDMQGNVVTFTGNVVVTQGTIKINADKVVVTRPGGEQGKEVIDGY-- 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840536981 101 kGKPAIFQQQLEDGSLISLQADEIKYQPNINLITVSGNAVVKQAGSEVSGSKITYNTLNEKLEAESNSNEAVTTILQPTI 180
Cdd:PRK10894   86 -GNPATFYQMQDNGKPVKGHASKMHYELAKDFVVLTGNAYLEQLDSNIKGDKITYLVKEQKMQAFSDKGKRVTTVLVPSQ 164


                  ....
gi 1840536981 181 LKNQ 184
Cdd:PRK10894  165 LQDK 168
LptD_N pfam03968
LptA/(LptD N-terminal domain) LPS transport protein; This family of proteins are involved in ...
 46-157 1.30e-19

LptA/(LptD N-terminal domain) LPS transport protein; This family of proteins are involved in lipopolysaccharide transport across the gram negative inner and outer membranes. The type examples for this family are E. coli LptA and the N-terminal domain of LptD.


Pssm-ID: 427621 [Multi-domain]  Cd Length: 113  Bit Score: 79.98  E-value: 1.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840536981  46 TIKSQRQSADLKNKIASYLDDVNIQQGSISIKADIVQVFSNNKDTEVEKADiylAKGKPAIFQQQLEDGSLISLQADEIK 125
Cdd:pfam03968   1 EIEADNAELDDKKNVATFTGNVIVTQGTLTLRADKVIVTQDKKKNGPERLE---ATGPATFRQKVDLVGRPIRGKADRIE 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1840536981 126 YQPNINLITVSGNAVVKQAGSEVSGSKITYNT 157
Cdd:pfam03968  78 YDVAKDIIVLTGNARLTQGGNSVRGDKITYDI 109
 
Name Accession Description Interval E-value
outer_YhbN_LptA TIGR03002
lipopolysaccharide transport periplasmic protein LptA; Members of this protein family include ...
 36-178 9.24e-44

lipopolysaccharide transport periplasmic protein LptA; Members of this protein family include LptA (previously called YhbN). It was shown to be an essential protein in E. coli, implicated in cell envelope integrity, and to play a role in the delivery of LPS to the outer leaflet of the outer membrane. It works with LptB (formerly yhbG), a homolog of ABC transporter ATP-binding proteins, encoded by an adjacent gene. Numerous homologs in other Proteobacteria are found in a conserved location near lipopolysaccharide inner core biosynthesis genes. This family is related to organic solvent tolerance protein (OstA), though distantly. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Transport and binding proteins, Other]


Pssm-ID: 274384 [Multi-domain]  Cd Length: 142  Bit Score: 142.75  E-value: 9.24e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840536981  36 AAKKDLEQEITIKSQRQSADLKNKIASYLDDVNIQQGSISIKADIVQVFSNNKdtevEKADIYLAKGKPAIFQQQLEDGS 115
Cdd:TIGR03002   1 ALTSDREQPIHIEADSQTLDDKKGVVTFTGNVVITQGTLKIRADKVVVTRNDA----GGIEKATATGKPATFRQKLDNGK 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1840536981 116 LISLQADEIKYQPNINLITVSGNAVVKQAGSEVSGSKITYNTLNEKLEAESNSNEA--VTTILQP 178
Cdd:TIGR03002  77 EIEGQANRIEYDPAKDEVVLTGNARLKQGGNEISGDVITYDTKKQKVIAKGDGGKTgrVTTIIQP 141
LptA COG1934
Lipopolysaccharide export system protein LptA [Cell wall/membrane/envelope biogenesis];
21-178 1.38e-34

Lipopolysaccharide export system protein LptA [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441537 [Multi-domain]  Cd Length: 164  Bit Score: 120.02  E-value: 1.38e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840536981  21 LLFLASTMLFSHSTLAAKKDLEQEITIKSQRQSADLKNKIASYLDDVNIQQGSISIKADIVQVFSNnKDTEVEKADiylA 100
Cdd:COG1934     2 LLLALLLLLLAAPALAQKADRDQPIEIEADRLEVDDKKGTAVFTGNVVVTQGTLTLRADKLVVYYD-KAGGIERIE---A 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1840536981 101 KGKpAIFQQQLEDGSLISLQADEIKYQPNINLITVSGNAVVKQAGSEVSGSKITYNTLNEKLEAESNSNEA-VTTILQP 178
Cdd:COG1934    78 TGN-VTFRQKRDGGQEVEATADRAEYDVATDTVVLTGNAVLTQGGNTVTGDRITYDLKTGRATAEGGGGGGrVRAVLQP 155
PRK10894 PRK10894
lipopolysaccharide ABC transporter substrate-binding protein LptA;
22-184 2.03e-25

lipopolysaccharide ABC transporter substrate-binding protein LptA;


Pssm-ID: 182816 [Multi-domain]  Cd Length: 180  Bit Score: 97.13  E-value: 2.03e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840536981  22 LFLASTML-FSHSTLAAKKDLEQEITIKSQRQSADLKNKIASYLDDVNIQQGSISIKADIVQVFSNNKDTEVEKADIYla 100
Cdd:PRK10894    8 LLLASSLLaASIPAFALTGDTDQPIHIDSDQQSLDMQGNVVTFTGNVVVTQGTIKINADKVVVTRPGGEQGKEVIDGY-- 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840536981 101 kGKPAIFQQQLEDGSLISLQADEIKYQPNINLITVSGNAVVKQAGSEVSGSKITYNTLNEKLEAESNSNEAVTTILQPTI 180
Cdd:PRK10894   86 -GNPATFYQMQDNGKPVKGHASKMHYELAKDFVVLTGNAYLEQLDSNIKGDKITYLVKEQKMQAFSDKGKRVTTVLVPSQ 164


                  ....
gi 1840536981 181 LKNQ 184
Cdd:PRK10894  165 LQDK 168
LptD_N pfam03968
LptA/(LptD N-terminal domain) LPS transport protein; This family of proteins are involved in ...
 46-157 1.30e-19

LptA/(LptD N-terminal domain) LPS transport protein; This family of proteins are involved in lipopolysaccharide transport across the gram negative inner and outer membranes. The type examples for this family are E. coli LptA and the N-terminal domain of LptD.


Pssm-ID: 427621 [Multi-domain]  Cd Length: 113  Bit Score: 79.98  E-value: 1.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840536981  46 TIKSQRQSADLKNKIASYLDDVNIQQGSISIKADIVQVFSNNKDTEVEKADiylAKGKPAIFQQQLEDGSLISLQADEIK 125
Cdd:pfam03968   1 EIEADNAELDDKKNVATFTGNVIVTQGTLTLRADKVIVTQDKKKNGPERLE---ATGPATFRQKVDLVGRPIRGKADRIE 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1840536981 126 YQPNINLITVSGNAVVKQAGSEVSGSKITYNT 157
Cdd:pfam03968  78 YDVAKDIIVLTGNARLTQGGNSVRGDKITYDI 109
LptD COG1452
LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall ...
 117-167 7.66e-06

LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441061 [Multi-domain]  Cd Length: 702  Bit Score: 45.75  E-value: 7.66e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1840536981 117 ISLQADEIKYQPNINLITVSGNAVVKQAGSEVSGSKITYNTLNEKLEAESN 167
Cdd:COG1452    21 VLIEADSLEYDQDDGTVTAEGNVEIRQGDRRLKADRVTYDQKTGTVTAEGN 71
LptD COG1452
LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall ...
 54-156 1.72e-05

LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441061 [Multi-domain]  Cd Length: 702  Bit Score: 44.59  E-value: 1.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1840536981  54 ADLKNKIASYLDDVNIQQGSISIKADivQVFSNNKDtevekaDIYLAKGKPAIFQQQledgslISLQADEIKYQPNINLI 133
Cdd:COG1452     1 AQDAAQALSVPDLAPDDDAPVLIEAD--SLEYDQDD------GTVTAEGNVEIRQGD------RRLKADRVTYDQKTGTV 66

                          90       100
                  ....*....|....*....|...
gi 1840536981 134 TVSGNAVVKQAGSEVSGSKITYN 156
Cdd:COG1452    67 TAEGNVRLTDGGNVLTGDEAELN 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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