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Conserved domains on  [gi|1842109638|ref|WP_171024749|]
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ATP-binding protein [Agathobacter rectalis]

Protein Classification

ATP-binding protein( domain architecture ID 13014794)

ATP-binding protein containing a histidine kinase-like ATPase domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 1-113 4.01e-26

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


:

Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 94.18  E-value: 4.01e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842109638   1 MNVKVVVPCNLNLSAYDMNIIFGNLLENAIEAQKDVK--NPSIDLEINYLMDSLVVEISNRCLQKVIFKGGLPVTTKQSv 78
Cdd:cd16935    20 FTIEIDIPILLPISPLDLCIIFGNLLDNAIEACAKIDkeNRFIHLKIRQKKGFLIISIENSYEGELKKKNGLFLSTKKD- 98

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1842109638  79 REHGYGLKNVKKVLDKYISTLDFECSDERFTVKIL 113
Cdd:cd16935    99 KNHGIGLKSIREIVKKYNGNLSIEYENGIFTLSIL 133
 
Name Accession Description Interval E-value
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 1-113 4.01e-26

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 94.18  E-value: 4.01e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842109638   1 MNVKVVVPCNLNLSAYDMNIIFGNLLENAIEAQKDVK--NPSIDLEINYLMDSLVVEISNRCLQKVIFKGGLPVTTKQSv 78
Cdd:cd16935    20 FTIEIDIPILLPISPLDLCIIFGNLLDNAIEACAKIDkeNRFIHLKIRQKKGFLIISIENSYEGELKKKNGLFLSTKKD- 98

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1842109638  79 REHGYGLKNVKKVLDKYISTLDFECSDERFTVKIL 113
Cdd:cd16935    99 KNHGIGLKSIREIVKKYNGNLSIEYENGIFTLSIL 133
HATPase_c_5 pfam14501
GHKL domain; This family represents the structurally related ATPase domains of histidine ...
 13-113 2.77e-23

GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433996 [Multi-domain]  Cd Length: 102  Bit Score: 86.12  E-value: 2.77e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842109638  13 LSAYDMNIIFGNLLENAIEAQKDV-KNPSIDLEINYLMDSLVVEISNRCLQKVIFKGGLPvTTKQSVREHGYGLKNVKKV 91
Cdd:pfam14501   1 ISDVDLCVIFGNLLDNAIEACSKIdDNRFIRLKIREKQNFLIIRIENTYEGELKFEGKLP-STKTKGDGHGIGLKSIRRI 79

                          90       100
                  ....*....|....*....|..
gi 1842109638  92 LDKYISTLDFECSDERFTVKIL 113
Cdd:pfam14501  80 VKKYGGNLSTEIENGIFTLSIL 101
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 10-112 4.74e-21

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 86.06  E-value: 4.74e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842109638  10 NLNLSAYDMNIIFGNLLENAIEA--QKDVKNPSIDLEINYLMDSLVVEISNRC------LQKVIFKGGlpVTTKQSvREH 81
Cdd:COG3290   274 DLPLSDTDLVTILGNLLDNAIEAveKLPEEERRVELSIRDDGDELVIEVEDSGpgipeeLLEKIFERG--FSTKLG-EGR 350

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1842109638  82 GYGLKNVKKVLDKYISTLDFECSDE---RFTVKI 112
Cdd:COG3290   351 GLGLALVKQIVEKYGGTIEVESEEGegtVFTVRL 384
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 21-109 4.11e-06

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 44.13  E-value: 4.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842109638  21 IFGNLLENAIEAQKDVKNPSIDLEINYLMDSLVVEISN------RCLQKVIFKGGlpVTTKQSvrEHGYGLKNVKKVLDK 94
Cdd:PRK11086  437 ILGNLIENALEAVGGEEGGEISVSLHYRNGWLHCEVSDdgpgiaPDEIDAIFDKG--YSTKGS--NRGVGLYLVKQSVEN 512

                          90
                  ....*....|....*
gi 1842109638  95 YISTLDFECSDERFT 109
Cdd:PRK11086  513 LGGSIAVESEPGVGT 527
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 21-112 2.42e-04

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 37.63  E-value: 2.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842109638   21 IFGNLLENAIEAQKDvkNPSIDLEINYLMDSLVVEISN------RCLQKVIFKGGlpVTTKQSVRE---HGYGLKNVKKV 91
Cdd:smart00387   9 VLSNLLDNAIKYTPE--GGRITVTLERDGDHVEITVEDngpgipPEDLEKIFEPF--FRTDKRSRKiggTGLGLSIVKKL 84

                           90       100
                   ....*....|....*....|....
gi 1842109638   92 LDKYISTLDFECSDE---RFTVKI 112
Cdd:smart00387  85 VELHGGEISVESEPGggtTFTITL 108
 
Name Accession Description Interval E-value
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 1-113 4.01e-26

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 94.18  E-value: 4.01e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842109638   1 MNVKVVVPCNLNLSAYDMNIIFGNLLENAIEAQKDVK--NPSIDLEINYLMDSLVVEISNRCLQKVIFKGGLPVTTKQSv 78
Cdd:cd16935    20 FTIEIDIPILLPISPLDLCIIFGNLLDNAIEACAKIDkeNRFIHLKIRQKKGFLIISIENSYEGELKKKNGLFLSTKKD- 98

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1842109638  79 REHGYGLKNVKKVLDKYISTLDFECSDERFTVKIL 113
Cdd:cd16935    99 KNHGIGLKSIREIVKKYNGNLSIEYENGIFTLSIL 133
HATPase_c_5 pfam14501
GHKL domain; This family represents the structurally related ATPase domains of histidine ...
 13-113 2.77e-23

GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433996 [Multi-domain]  Cd Length: 102  Bit Score: 86.12  E-value: 2.77e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842109638  13 LSAYDMNIIFGNLLENAIEAQKDV-KNPSIDLEINYLMDSLVVEISNRCLQKVIFKGGLPvTTKQSVREHGYGLKNVKKV 91
Cdd:pfam14501   1 ISDVDLCVIFGNLLDNAIEACSKIdDNRFIRLKIREKQNFLIIRIENTYEGELKFEGKLP-STKTKGDGHGIGLKSIRRI 79

                          90       100
                  ....*....|....*....|..
gi 1842109638  92 LDKYISTLDFECSDERFTVKIL 113
Cdd:pfam14501  80 VKKYGGNLSTEIENGIFTLSIL 101
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 10-112 4.74e-21

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 86.06  E-value: 4.74e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842109638  10 NLNLSAYDMNIIFGNLLENAIEA--QKDVKNPSIDLEINYLMDSLVVEISNRC------LQKVIFKGGlpVTTKQSvREH 81
Cdd:COG3290   274 DLPLSDTDLVTILGNLLDNAIEAveKLPEEERRVELSIRDDGDELVIEVEDSGpgipeeLLEKIFERG--FSTKLG-EGR 350

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1842109638  82 GYGLKNVKKVLDKYISTLDFECSDE---RFTVKI 112
Cdd:COG3290   351 GLGLALVKQIVEKYGGTIEVESEEGegtVFTVRL 384
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 21-91 5.47e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 44.59  E-value: 5.47e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1842109638  21 IFGNLLENAIEAQKDVKNPS--IDLEINYLMDSLVVEIS-NRC-----LQKVIFKGGlpVTTKQSvREHGYGLKNVKKV 91
Cdd:cd16915     4 IVGNLIDNALDALAATGAPNkqVEVFLRDEGDDLVIEVRdTGPgiapeLRDKVFERG--VSTKGQ-GERGIGLALVRQS 79
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 21-109 4.11e-06

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 44.13  E-value: 4.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842109638  21 IFGNLLENAIEAQKDVKNPSIDLEINYLMDSLVVEISN------RCLQKVIFKGGlpVTTKQSvrEHGYGLKNVKKVLDK 94
Cdd:PRK11086  437 ILGNLIENALEAVGGEEGGEISVSLHYRNGWLHCEVSDdgpgiaPDEIDAIFDKG--YSTKGS--NRGVGLYLVKQSVEN 512

                          90
                  ....*....|....*
gi 1842109638  95 YISTLDFECSDERFT 109
Cdd:PRK11086  513 LGGSIAVESEPGVGT 527
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 21-116 1.63e-04

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 38.12  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842109638  21 IFGNLLENAIEAQKDVKNPSIDLEINylmDSLVVEISNRC------LQKVIFkGGLPVTTKQSVREHGYGLKNVKKVLDK 94
Cdd:pfam02518   9 VLSNLLDNALKHAAKAGEITVTLSEG---GELTLTVEDNGigippeDLPRIF-EPFSTADKRGGGGTGLGLSIVRKLVEL 84

                          90       100
                  ....*....|....*....|....*
gi 1842109638  95 YISTLDFECSDE---RFTVKILMKI 116
Cdd:pfam02518  85 LGGTITVESEPGggtTVTLTLPLAQ 109
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 21-112 2.42e-04

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 37.63  E-value: 2.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842109638   21 IFGNLLENAIEAQKDvkNPSIDLEINYLMDSLVVEISN------RCLQKVIFKGGlpVTTKQSVRE---HGYGLKNVKKV 91
Cdd:smart00387   9 VLSNLLDNAIKYTPE--GGRITVTLERDGDHVEITVEDngpgipPEDLEKIFEPF--FRTDKRSRKiggTGLGLSIVKKL 84

                           90       100
                   ....*....|....*....|....
gi 1842109638   92 LDKYISTLDFECSDE---RFTVKI 112
Cdd:smart00387  85 VELHGGEISVESEPGggtTFTITL 108
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 21-82 3.79e-03

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 35.32  E-value: 3.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842109638  21 IFGNLLENAIEAQKDvkNPSIDLEINYLMDSLVVEISNR-------CLQKvIF--------KG---GLPVtTKQSVREHG 82
Cdd:COG5000   321 VLINLLKNAIEAIEE--GGEIEVSTRREDGRVRIEVSDNgpgipeeVLER-IFepffttkpKGtglGLAI-VKKIVEEHG 396
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 12-85 8.69e-03

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 34.42  E-value: 8.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842109638  12 NLSAYDMNIIFGNLLENAIEAQkdVKNPSIDLEIN-YLMDS---LVVEISNR-C-----LQKVIFKGGlpVTTKQS-VRE 80
Cdd:PRK15053  427 GLDSTEFAAIVGNLLDNAFEAS--LRSDEGNKIVElFLSDEgddVVIEVADQgCgvpesLRDKIFEQG--VSTRADePGE 502


                  ....*
gi 1842109638  81 HGYGL 85
Cdd:PRK15053  503 HGIGL 507
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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