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Conserved domains on  [gi|1856573029|ref|WP_174593410|]
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site-specific integrase, partial [Escherichia coli]

Protein Classification

site-specific integrase( domain architecture ID 10092426)

tyrosine based site-specific recombinase (integrase) is involved in cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct

CATH:  1.10.443.10
Gene Ontology:  GO:0015074|GO:0003677|GO:0006310
PubMed:  10047575|9278480|10577069

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
INT_P4_C cd00801
Bacteriophage P4 integrase, C-terminal catalytic domain; P4-like integrases are found in ...
 3-182 4.19e-60

Bacteriophage P4 integrase, C-terminal catalytic domain; P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. The P4 integrase mediates integrative and excisive site-specific recombination between two sites, called attachment sites, located on the phage genome and the bacterial chromosome. The phage attachment site is often found adjacent to the integrase gene, while the host attachment sites are typically situated near tRNA genes. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.


:

Pssm-ID: 271182 [Multi-domain]  Cd Length: 180  Bit Score: 185.17  E-value: 4.19e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856573029   3 TDDEIRDLWRSINTDydnhELSYENRIILRFLVVFGCRLSEVLLSSWVEWDFDKKLWRVPADHSKNGREIIRPIPDGMFN 82
Cdd:cd00801     1 SPDELPELWRALDTA----NLSPPTKLALRLLLLTGQRIGELARARWSEIDLEEKTWTIPAERTKNKRPHRVPLSDQALE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856573029  83 WLVTLKKITGNKENVigFDMR----QCTASVTIGKTWKRM-KHSEKWTAHDMRRVFATKLSDHGFEHNVVEQLLGHTLGG 157
Cdd:cd00801    77 ILEELKEFTGDSGYL--FPSRrkkkKPISENTINKALKRLgYKGKEFTPHDLRRTFSTLLNELGIDPEVIERLLNHVLGG 154

                         170       180
                  ....*....|....*....|....*.
gi 1856573029 158 -VAGVYNRSQYMDRKKEAMNWWYDYL 182
Cdd:cd00801   155 vVRAAYNRYDYLEERREALQAWADYL 180
 
Name Accession Description Interval E-value
INT_P4_C cd00801
Bacteriophage P4 integrase, C-terminal catalytic domain; P4-like integrases are found in ...
 3-182 4.19e-60

Bacteriophage P4 integrase, C-terminal catalytic domain; P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. The P4 integrase mediates integrative and excisive site-specific recombination between two sites, called attachment sites, located on the phage genome and the bacterial chromosome. The phage attachment site is often found adjacent to the integrase gene, while the host attachment sites are typically situated near tRNA genes. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.


Pssm-ID: 271182 [Multi-domain]  Cd Length: 180  Bit Score: 185.17  E-value: 4.19e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856573029   3 TDDEIRDLWRSINTDydnhELSYENRIILRFLVVFGCRLSEVLLSSWVEWDFDKKLWRVPADHSKNGREIIRPIPDGMFN 82
Cdd:cd00801     1 SPDELPELWRALDTA----NLSPPTKLALRLLLLTGQRIGELARARWSEIDLEEKTWTIPAERTKNKRPHRVPLSDQALE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856573029  83 WLVTLKKITGNKENVigFDMR----QCTASVTIGKTWKRM-KHSEKWTAHDMRRVFATKLSDHGFEHNVVEQLLGHTLGG 157
Cdd:cd00801    77 ILEELKEFTGDSGYL--FPSRrkkkKPISENTINKALKRLgYKGKEFTPHDLRRTFSTLLNELGIDPEVIERLLNHVLGG 154

                         170       180
                  ....*....|....*....|....*.
gi 1856573029 158 -VAGVYNRSQYMDRKKEAMNWWYDYL 182
Cdd:cd00801   155 vVRAAYNRYDYLEERREALQAWADYL 180
FimB COG0582
Integrase/recombinase, includes phage integrase [Replication, recombination and repair, ...
 2-188 2.23e-47

Integrase/recombinase, includes phage integrase [Replication, recombination and repair, Mobilome: prophages, transposons];


Pssm-ID: 440347 [Multi-domain]  Cd Length: 391  Bit Score: 159.05  E-value: 2.23e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856573029   2 LTDDEIRDLWRSIntdyDNHELSYENRIILRFLVVFGCRLSEVLLSSWVEWDFDKKLWRVPADHSKNGREIIRPIPDGMF 81
Cdd:COG0582   206 LTPEELPELLRAL----DAYRGSPVTRLALRLLLLTGVRPGELRGARWSEIDLEAALWTIPAERMKTRRPHIVPLSRQAL 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856573029  82 NWLVTLKKITGNKENVigFDMRQCTASVTIGKTW----KRMKHsEKWTAHDMRRVFATKLSDHGFEHNVVEQLLGHTLG- 156
Cdd:COG0582   282 EILKELKPLTGDSEYV--FPSRRGPKKPMSENTLnkalRRMGY-GRFTPHGFRHTASTLLNEAGFPPDVIERQLAHKDGn 358

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1856573029 157 GVAGVYNRSQYMDRKKEAMNWWYDYLNKLISG 188
Cdd:COG0582   359 KVRAAYNRADYLEERREMMQWWADYLDALRAG 390
PRK09692 PRK09692
integrase; Provisional
 40-188 4.01e-22

integrase; Provisional


Pssm-ID: 170049 [Multi-domain]  Cd Length: 413  Bit Score: 92.01  E-value: 4.01e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856573029  40 RLSEVLLSSWVEWDFDKKLWRVPADHSKNGREIIRPIPDGMFNWLVTLKKITGNKENVigFDMR----QCTASVTIGKTW 115
Cdd:PRK09692  248 RPAEAAEARWEEIDIEAQEWKIPAARMKMNRDHTVPLSDEALAILEMMKPLSGNREFI--FPSRikpnQPMNSQTVNAAL 325

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1856573029 116 KRMKHSEKWTAHDMRRVFATKLSDHGFEHNVVEQLLGHT-LGGVAGVYNRSQYMDRKKEAMNWWYDYLNKLISG 188
Cdd:PRK09692  326 KRAGLGGVLVSHGLRSIASTALNEQGFPPDVIEAALAHVdKNEVRRAYNRSDYLEQRRPMMQWWADFVMAADSG 399
Phage_integrase pfam00589
Phage integrase family; Members of this family cleave DNA substrates by a series of staggered ...
 1-167 2.55e-13

Phage integrase family; Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase are Arg-173, His-289, Arg-292 and Tyr-324.


Pssm-ID: 395471 [Multi-domain]  Cd Length: 169  Bit Score: 64.65  E-value: 2.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856573029   1 VLTDDEIRDLWRSINTDydnhELSYENRIILRFLVVFGCRLSEVLLSSWVEWDFDKKLWRVPadHSKNGREIIRPIPDGM 80
Cdd:pfam00589   1 RLTEDEVERLLDAAETG----PLSIRDKALLELLYATGLRISELCSLRWSDIDFENGVIRVH--RGKGNKERTVPLSDAA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856573029  81 FNWLVTLKKITGNKENV-----IGFDMRQCTASvTIGKTWKRMKH----SEKWTAHDMRRVFATKLSDHGFEHNVVEQLL 151
Cdd:pfam00589  75 LELLKEWLSKRLLEAPKsdylfASKRGKPLSRQ-TVRKIFKRAGKeaglELPLHPHMLRHSFATHLLEAGVDLRVVQKLL 153

                         170
                  ....*....|....*.
gi 1856573029 152 GHTLGGVAGVYNRSQY 167
Cdd:pfam00589 154 GHSSISTTQIYTHVAD 169
 
Name Accession Description Interval E-value
INT_P4_C cd00801
Bacteriophage P4 integrase, C-terminal catalytic domain; P4-like integrases are found in ...
 3-182 4.19e-60

Bacteriophage P4 integrase, C-terminal catalytic domain; P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. The P4 integrase mediates integrative and excisive site-specific recombination between two sites, called attachment sites, located on the phage genome and the bacterial chromosome. The phage attachment site is often found adjacent to the integrase gene, while the host attachment sites are typically situated near tRNA genes. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.


Pssm-ID: 271182 [Multi-domain]  Cd Length: 180  Bit Score: 185.17  E-value: 4.19e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856573029   3 TDDEIRDLWRSINTDydnhELSYENRIILRFLVVFGCRLSEVLLSSWVEWDFDKKLWRVPADHSKNGREIIRPIPDGMFN 82
Cdd:cd00801     1 SPDELPELWRALDTA----NLSPPTKLALRLLLLTGQRIGELARARWSEIDLEEKTWTIPAERTKNKRPHRVPLSDQALE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856573029  83 WLVTLKKITGNKENVigFDMR----QCTASVTIGKTWKRM-KHSEKWTAHDMRRVFATKLSDHGFEHNVVEQLLGHTLGG 157
Cdd:cd00801    77 ILEELKEFTGDSGYL--FPSRrkkkKPISENTINKALKRLgYKGKEFTPHDLRRTFSTLLNELGIDPEVIERLLNHVLGG 154

                         170       180
                  ....*....|....*....|....*.
gi 1856573029 158 -VAGVYNRSQYMDRKKEAMNWWYDYL 182
Cdd:cd00801   155 vVRAAYNRYDYLEERREALQAWADYL 180
FimB COG0582
Integrase/recombinase, includes phage integrase [Replication, recombination and repair, ...
 2-188 2.23e-47

Integrase/recombinase, includes phage integrase [Replication, recombination and repair, Mobilome: prophages, transposons];


Pssm-ID: 440347 [Multi-domain]  Cd Length: 391  Bit Score: 159.05  E-value: 2.23e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856573029   2 LTDDEIRDLWRSIntdyDNHELSYENRIILRFLVVFGCRLSEVLLSSWVEWDFDKKLWRVPADHSKNGREIIRPIPDGMF 81
Cdd:COG0582   206 LTPEELPELLRAL----DAYRGSPVTRLALRLLLLTGVRPGELRGARWSEIDLEAALWTIPAERMKTRRPHIVPLSRQAL 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856573029  82 NWLVTLKKITGNKENVigFDMRQCTASVTIGKTW----KRMKHsEKWTAHDMRRVFATKLSDHGFEHNVVEQLLGHTLG- 156
Cdd:COG0582   282 EILKELKPLTGDSEYV--FPSRRGPKKPMSENTLnkalRRMGY-GRFTPHGFRHTASTLLNEAGFPPDVIERQLAHKDGn 358

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1856573029 157 GVAGVYNRSQYMDRKKEAMNWWYDYLNKLISG 188
Cdd:COG0582   359 KVRAAYNRADYLEERREMMQWWADYLDALRAG 390
PRK09692 PRK09692
integrase; Provisional
 40-188 4.01e-22

integrase; Provisional


Pssm-ID: 170049 [Multi-domain]  Cd Length: 413  Bit Score: 92.01  E-value: 4.01e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856573029  40 RLSEVLLSSWVEWDFDKKLWRVPADHSKNGREIIRPIPDGMFNWLVTLKKITGNKENVigFDMR----QCTASVTIGKTW 115
Cdd:PRK09692  248 RPAEAAEARWEEIDIEAQEWKIPAARMKMNRDHTVPLSDEALAILEMMKPLSGNREFI--FPSRikpnQPMNSQTVNAAL 325

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1856573029 116 KRMKHSEKWTAHDMRRVFATKLSDHGFEHNVVEQLLGHT-LGGVAGVYNRSQYMDRKKEAMNWWYDYLNKLISG 188
Cdd:PRK09692  326 KRAGLGGVLVSHGLRSIASTALNEQGFPPDVIEAALAHVdKNEVRRAYNRSDYLEQRRPMMQWWADFVMAADSG 399
INT_Rci_Hp1_C cd00796
Shufflon-specific DNA recombinase Rci and Bacteriophage Hp1_like integrase, C-terminal ...
 2-154 2.12e-17

Shufflon-specific DNA recombinase Rci and Bacteriophage Hp1_like integrase, C-terminal catalytic domain; Rci protein is a tyrosine recombinase specifically involved in Shufflon type of DNA rearrangement in bacteria. The shufflon of plasmid R64 consists of four invertible DNA segments which are separated and flanked by seven 19-bp repeat sequences. RCI recombinase facilitates the site-specific recombination between any inverted repeats results in an inversion of the DNA segment(s) either independently or in groups. HP1 integrase promotes site-specific recombination of the HP1 genome into that of Haemophilus influenza. Bacteriophage Hp1_like integrases are tyrosine based site specific recombinases. They belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.


Pssm-ID: 271177 [Multi-domain]  Cd Length: 162  Bit Score: 75.44  E-value: 2.12e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856573029   2 LTDDEIRDLWRSINTDYDNHElsyenRIILRFLVVFGCRLSEVLLSSWVEWDFDKklWRVPADHSKNGREIIRPIPDG-- 79
Cdd:cd00796     5 LTEDEEARLLAALEESTNPHL-----RLIVLLALYTGARRGEILSLRWDDIDLEV--GLIVLPETKNGKPRTVPLSDEai 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1856573029  80 -MFNWLVTLKKITGNKENVIGFDMRQctasVTIGKTWKRMKHS---EKWTAHDMRRVFATKLSDHGFEHNVVEQLLGHT 154
Cdd:cd00796    78 aILKELKRKRGKDGFFVDGRFFGIPI----ASLRRAFKKARKRaglEDLRFHDLRHTFASRLVQAGVPIKTVAKILGHS 152
XerD COG4974
Site-specific recombinase XerD [Replication, recombination and repair];
1-176 3.80e-17

Site-specific recombinase XerD [Replication, recombination and repair];


Pssm-ID: 443999 [Multi-domain]  Cd Length: 291  Bit Score: 76.96  E-value: 3.80e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856573029   1 VLTDDEIRDLWRSINTDydnHELSYENRIILRFLVVFGCRLSEVLLSSWVEWDFDKKLWRVPadHSKNGREIIRPIPDGM 80
Cdd:COG4974   112 VLTEEEIEALLEALDTE---TPEGLRDRALLLLLYATGLRVSELLGLKWSDIDLDRGTIRVR--RGKGGKERTVPLSPEA 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856573029  81 FNWLVTLKKITGNKEN---VIGFDMRQCTASvTIGKTWKRMKH----SEKWTAHDMRRVFATKLSDHGFEHNVVEQLLGH 153
Cdd:COG4974   187 LEALREYLEERRPRDSdylFPTRRGRPLSRR-AIRKILKRLAKragiPKRVTPHSLRHTFATHLLEAGVDLRTVQELLGH 265

                         170       180
                  ....*....|....*....|...
gi 1856573029 154 TLGGVAGVYNRSQyMDRKKEAMN 176
Cdd:COG4974   266 SSISTTQIYTHVS-DEELREAVE 287
Phage_integrase pfam00589
Phage integrase family; Members of this family cleave DNA substrates by a series of staggered ...
 1-167 2.55e-13

Phage integrase family; Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase are Arg-173, His-289, Arg-292 and Tyr-324.


Pssm-ID: 395471 [Multi-domain]  Cd Length: 169  Bit Score: 64.65  E-value: 2.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856573029   1 VLTDDEIRDLWRSINTDydnhELSYENRIILRFLVVFGCRLSEVLLSSWVEWDFDKKLWRVPadHSKNGREIIRPIPDGM 80
Cdd:pfam00589   1 RLTEDEVERLLDAAETG----PLSIRDKALLELLYATGLRISELCSLRWSDIDFENGVIRVH--RGKGNKERTVPLSDAA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856573029  81 FNWLVTLKKITGNKENV-----IGFDMRQCTASvTIGKTWKRMKH----SEKWTAHDMRRVFATKLSDHGFEHNVVEQLL 151
Cdd:pfam00589  75 LELLKEWLSKRLLEAPKsdylfASKRGKPLSRQ-TVRKIFKRAGKeaglELPLHPHMLRHSFATHLLEAGVDLRVVQKLL 153

                         170
                  ....*....|....*.
gi 1856573029 152 GHTLGGVAGVYNRSQY 167
Cdd:pfam00589 154 GHSSISTTQIYTHVAD 169
DNA_BRE_C cd00397
DNA breaking-rejoining enzymes, C-terminal catalytic domain; The DNA breaking-rejoining enzyme ...
 6-154 1.12e-12

DNA breaking-rejoining enzymes, C-terminal catalytic domain; The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.


Pssm-ID: 271175 [Multi-domain]  Cd Length: 167  Bit Score: 62.88  E-value: 1.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856573029   6 EIRDLWRSINTDYDNHelsYENRIILRFLVVFGCRLSEVLLSSWVEWDFDKKLWRVPADHSKNGREIIRPIPDGMFNWLV 85
Cdd:cd00397     1 ELEKLLDAIDEDKKID---LRDRAILLLLLETGLRISELLALKVKDIDLDNGTIRVRGKKTKGGKERTVPLPKELAEELK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856573029  86 TL------KKITGNKENVIGFDMRQCTASVTIGKTWKRM------KHSEKWTAHDMRRVFATKLSDHGFEHNVVEQLLGH 153
Cdd:cd00397    78 EYlkerrdKRGPLLKSLYLNKLFGTKLGERLSRRTLRRIfkkagiEAGRKITPHSLRHTFATNLLENGVDIKVVQKLLGH 157


                  .
gi 1856573029 154 T 154
Cdd:cd00397   158 S 158
XerC COG4973
Site-specific recombinase XerC [Replication, recombination and repair];
1-164 2.85e-11

Site-specific recombinase XerC [Replication, recombination and repair];


Pssm-ID: 443998 [Multi-domain]  Cd Length: 287  Bit Score: 60.75  E-value: 2.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856573029   1 VLTDDEIRDLWRSINTDydnhELSYENRIILRFLVVFGCRLSEVLLSSWVEWDFDKKLWRVpadHSKNGREIIRPIPDGM 80
Cdd:COG4973   111 ALTVDELAQLLDALADD----PLAVRDRAIVELLYSTGLRLGELVGLDWEDVDLDAGEVRV---RGKTGKSRTVPLGPKA 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1856573029  81 F----NWLVTLKKITGNKEN--VIGFDMRQCTASvTIGKTWKRM----KHSEKWTAHDMRRVFATKLSDHGFEHNVVEQL 150
Cdd:COG4973   184 LaalrEWLAVRPELAAPDEGalFPSRRGTRLSPR-NVQKRLRRLakkaGLPKHVHPHDLRHSFATHLLESGGDLRAVQEL 262

                         170
                  ....*....|....
gi 1856573029 151 LGHTLGGVAGVYNR 164
Cdd:COG4973   263 LGHASISTTQIYTH 276
xerD PRK00283
tyrosine recombinase;
115-153 3.23e-03

tyrosine recombinase;


Pssm-ID: 234713 [Multi-domain]  Cd Length: 299  Bit Score: 37.48  E-value: 3.23e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1856573029 115 WKRMKH--------SEKWTAHDMRRVFATKLSDHGFEHNVVEQLLGH 153
Cdd:PRK00283  225 WHRIKHyakragidPKKLSPHVLRHAFATHLLNHGADLRVVQELLGH 271
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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