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Conserved domains on  [gi|1871780720|ref|WP_179967771|]
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glutaredoxin family protein [Mycolicibacterium monacense]

Protein Classification

glutaredoxin family protein( domain architecture ID 10530477)

glutaredoxin/thioredoxin family protein functions as a thiol disulfide oxidoreductase that catalyzes the oxidation or reduction of protein thiol or disulfide bonds using an active site disulfide or dithiol, present in a CXXC motif

CATH:  3.40.30.10
PubMed:  11441809|11012661|14713336
SCOP:  4000237

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glrx-like pfam05768
Glutaredoxin-like domain (DUF836); These proteins are related to the pfam00462 family. This ...
 5-82 2.02e-17

Glutaredoxin-like domain (DUF836); These proteins are related to the pfam00462 family. This entry includes several viral glutaredoxins and many related bacterial and eukaryotic proteins of unknown function. The best characterized member is G4L from Vaccinia virus (strain Western Reserve/WR) (VACV), which is necessary for virion morphogenesis and replication. This is a cytoplasmic protein which functions as a shuttle in a redox pathway between membrane-associated E10R and L1R or F9L.


:

Pssm-ID: 399055  Cd Length: 80  Bit Score: 69.24  E-value: 2.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871780720  5 IELLTRAGCGLCEQAAARLAELSGELGFGLTITDVdaaaaGGDAALRAEYGDRLPVVLLDG------AEHSYWEIDEPRL 78
Cdd:pfam05768  1 LTLYGKPGCGLCEGAEEVLEPLALELGFELEVIDI-----DGDPELLAKYGLEIPVLAFVGiskffnLEILSWRLDEEQL 75


                 ....
gi 1871780720 79 RADL 82
Cdd:pfam05768 76 AAEL 79
 
Name Accession Description Interval E-value
Glrx-like pfam05768
Glutaredoxin-like domain (DUF836); These proteins are related to the pfam00462 family. This ...
 5-82 2.02e-17

Glutaredoxin-like domain (DUF836); These proteins are related to the pfam00462 family. This entry includes several viral glutaredoxins and many related bacterial and eukaryotic proteins of unknown function. The best characterized member is G4L from Vaccinia virus (strain Western Reserve/WR) (VACV), which is necessary for virion morphogenesis and replication. This is a cytoplasmic protein which functions as a shuttle in a redox pathway between membrane-associated E10R and L1R or F9L.


Pssm-ID: 399055  Cd Length: 80  Bit Score: 69.24  E-value: 2.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871780720  5 IELLTRAGCGLCEQAAARLAELSGELGFGLTITDVdaaaaGGDAALRAEYGDRLPVVLLDG------AEHSYWEIDEPRL 78
Cdd:pfam05768  1 LTLYGKPGCGLCEGAEEVLEPLALELGFELEVIDI-----DGDPELLAKYGLEIPVLAFVGiskffnLEILSWRLDEEQL 75


                 ....
gi 1871780720 79 RADL 82
Cdd:pfam05768 76 AAEL 79
GrxC COG0695
Glutaredoxin [Posttranslational modification, protein turnover, chaperones];
5-83 3.34e-04

Glutaredoxin [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440459 [Multi-domain]  Cd Length: 74  Bit Score: 35.56  E-value: 3.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871780720  5 IELLTRAGCGLCEQAAARLAelsgELGFGLTITDVdAAAAGGDAALRAEYGDR-LPVVLLDGAEHSywEIDEPRLRADLG 83
Cdd:COG0695    2 VTLYTTPGCPYCARAKRLLD----EKGIPYEEIDV-DEDPEAREELRERSGRRtVPVIFIGGEHLG--GFDEGELDALLA 74
 
Name Accession Description Interval E-value
Glrx-like pfam05768
Glutaredoxin-like domain (DUF836); These proteins are related to the pfam00462 family. This ...
 5-82 2.02e-17

Glutaredoxin-like domain (DUF836); These proteins are related to the pfam00462 family. This entry includes several viral glutaredoxins and many related bacterial and eukaryotic proteins of unknown function. The best characterized member is G4L from Vaccinia virus (strain Western Reserve/WR) (VACV), which is necessary for virion morphogenesis and replication. This is a cytoplasmic protein which functions as a shuttle in a redox pathway between membrane-associated E10R and L1R or F9L.


Pssm-ID: 399055  Cd Length: 80  Bit Score: 69.24  E-value: 2.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871780720  5 IELLTRAGCGLCEQAAARLAELSGELGFGLTITDVdaaaaGGDAALRAEYGDRLPVVLLDG------AEHSYWEIDEPRL 78
Cdd:pfam05768  1 LTLYGKPGCGLCEGAEEVLEPLALELGFELEVIDI-----DGDPELLAKYGLEIPVLAFVGiskffnLEILSWRLDEEQL 75


                 ....
gi 1871780720 79 RADL 82
Cdd:pfam05768 76 AAEL 79
GrxC COG0695
Glutaredoxin [Posttranslational modification, protein turnover, chaperones];
5-83 3.34e-04

Glutaredoxin [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440459 [Multi-domain]  Cd Length: 74  Bit Score: 35.56  E-value: 3.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1871780720  5 IELLTRAGCGLCEQAAARLAelsgELGFGLTITDVdAAAAGGDAALRAEYGDR-LPVVLLDGAEHSywEIDEPRLRADLG 83
Cdd:COG0695    2 VTLYTTPGCPYCARAKRLLD----EKGIPYEEIDV-DEDPEAREELRERSGRRtVPVIFIGGEHLG--GFDEGELDALLA 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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