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Conserved domains on  [gi|1893778545|ref|WP_185693567|]
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type II secretion system protein [Puniceicoccus vermicola]

Protein Classification

type II secretion system protein( domain architecture ID 11450365)

type II secretion system protein similar to Pseudomonas aeruginosa type II secretion system protein H, which is involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins; required for the translocation of a variety of enzymes across the outer membrane; pilin similar to fimbrial protein PilE, which is required for pilus biogenesis, as well as fimbrial protein PilA, which is responsible for the adhesive property of the pilus

Gene Ontology:  GO:0005886|GO:0015628|GO:0015627
PubMed:  30767847|1365398

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 1-95 3.71e-16

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


:

Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 71.48  E-value: 3.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893778545   1 MKRNHQGFTLLELLTVIAVVAILFSITVVAVGKVRESANTTKCASNLRSLGQAWLAYGNEHQGasLPYRNPDGGSTSWML 80
Cdd:COG2165     6 RRRRQRGFTLIELLVVIAIIGILAALALPALQGARERARRAELRSNLRQIQQALERYRLDNGR--YPSSLTGLLADVRGG 83

                          90
                  ....*....|....*
gi 1893778545  81 QILPYIDTDSNVFTC 95
Cdd:COG2165    84 GYLGSNGLPPAGTPC 98
 
Name Accession Description Interval E-value
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 1-95 3.71e-16

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 71.48  E-value: 3.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893778545   1 MKRNHQGFTLLELLTVIAVVAILFSITVVAVGKVRESANTTKCASNLRSLGQAWLAYGNEHQGasLPYRNPDGGSTSWML 80
Cdd:COG2165     6 RRRRQRGFTLIELLVVIAIIGILAALALPALQGARERARRAELRSNLRQIQQALERYRLDNGR--YPSSLTGLLADVRGG 83

                          90
                  ....*....|....*
gi 1893778545  81 QILPYIDTDSNVFTC 95
Cdd:COG2165    84 GYLGSNGLPPAGTPC 98
IV_pilin_GFxxxE TIGR02532
prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all ...
 5-28 3.26e-05

prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all examples of the N-terminal region of bacterial proteins that resemble type IV pilins at their N-terminus, with a cleavage site G^FxxxE followed by a hydrophobic stretch. The new N-terminal residue, usually Phe, is methylated. Separate domains of the prepilin peptidase appear responsible for cleavage and methylation. Proteins with this N-terminal region include type IV pilins and other components of pilus biogenesis, competence proteins, and type II secretion proteins. Typically several proteins in a single operon have this N-terminal domain. The N-terminal cleavage and methylation site is described by PROSITE motif PS00409 as [KRHEQSTAG]-G-[FYLIVM]-[ST]-[LT]-[LIVP]-E-[LIVMFWSTAG](14). [Cell envelope, Surface structures, Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274182 [Multi-domain]  Cd Length: 24  Bit Score: 39.60  E-value: 3.26e-05
                          10        20
                  ....*....|....*....|....
gi 1893778545   5 HQGFTLLELLTVIAVVAILFSITV 28
Cdd:TIGR02532   1 QRGFTLIELLVVLAILGILALIAL 24
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 2-28 4.07e-05

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 39.28  E-value: 4.07e-05
                          10        20
                  ....*....|....*....|....*..
gi 1893778545   2 KRNHQGFTLLELLTVIAVVAILFSITV 28
Cdd:pfam07963   1 MRKQRGFTLIELLVALAILAILLAAAL 27
PRK10574 PRK10574
putative major pilin subunit; Provisional
 4-30 1.78e-04

putative major pilin subunit; Provisional


Pssm-ID: 236718 [Multi-domain]  Cd Length: 146  Bit Score: 40.40  E-value: 1.78e-04
                          10        20
                  ....*....|....*....|....*..
gi 1893778545   4 NHQGFTLLELLTVIAVVAILFSITVVA 30
Cdd:PRK10574    3 KQRGFTLIELMVVIAIIAILSAIGIPA 29
 
Name Accession Description Interval E-value
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 1-95 3.71e-16

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 71.48  E-value: 3.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893778545   1 MKRNHQGFTLLELLTVIAVVAILFSITVVAVGKVRESANTTKCASNLRSLGQAWLAYGNEHQGasLPYRNPDGGSTSWML 80
Cdd:COG2165     6 RRRRQRGFTLIELLVVIAIIGILAALALPALQGARERARRAELRSNLRQIQQALERYRLDNGR--YPSSLTGLLADVRGG 83

                          90
                  ....*....|....*
gi 1893778545  81 QILPYIDTDSNVFTC 95
Cdd:COG2165    84 GYLGSNGLPPAGTPC 98
ComGC COG4537
Competence protein ComGC [Mobilome: prophages, transposons];
1-97 1.04e-10

Competence protein ComGC [Mobilome: prophages, transposons];


Pssm-ID: 443603 [Multi-domain]  Cd Length: 108  Bit Score: 56.86  E-value: 1.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893778545   1 MKRNHQGFTLLELLTVIAVVAILFSITVVAVGKVRESANTTKCASNLRSLgqawlaygnehQGASLPYRNpDGGSTSWML 80
Cdd:COG4537     7 KLKKEKGFTLIEMLIVLLIISILLLIAVPNLTKQRETAQEKGCEANIKMV-----------QSQVELYEL-DHGTYPASL 74

                          90       100
                  ....*....|....*....|
gi 1893778545  81 QIL---PYIdtDSNVFTCPS 97
Cdd:COG4537    75 EELvdeGYL--KEKQPTCPN 92
PilE COG4968
Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];
1-57 1.15e-10

Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];


Pssm-ID: 443994 [Multi-domain]  Cd Length: 124  Bit Score: 57.39  E-value: 1.15e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1893778545   1 MKRNHQGFTLLELLTVIAVVAILFSITVVAVGKVRESANTTKCASNLRSLGQAWLAY 57
Cdd:COG4968     5 MRRRQRGFTLIELMIVVAIIGILAAIAIPSYQDYVERARRAEAKAALLELAQAQERY 61
FimT COG4970
Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];
1-50 2.01e-10

Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];


Pssm-ID: 443996 [Multi-domain]  Cd Length: 73  Bit Score: 55.24  E-value: 2.01e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1893778545   1 MKRNHQGFTLLELLTVIAVVAILFSITVVAVGKVRESANTTKCASNLRSL 50
Cdd:COG4970     4 LRRRQRGFTLIELLVVLAILAILAAIAVPSFSSLIARQRLRAAANELAAA 53
PilA COG4969
Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];
1-50 6.57e-07

Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];


Pssm-ID: 443995 [Multi-domain]  Cd Length: 134  Bit Score: 47.01  E-value: 6.57e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1893778545   1 MKRNHQGFTLLELLTVIAVVAILFSITVVAVGKVRESANTTKCASNLRSL 50
Cdd:COG4969     1 MKKKQKGFTLIELMIVVAIIGILAAIAIPAYQDYVARARVSEALALASPL 50
IV_pilin_GFxxxE TIGR02532
prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all ...
 5-28 3.26e-05

prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all examples of the N-terminal region of bacterial proteins that resemble type IV pilins at their N-terminus, with a cleavage site G^FxxxE followed by a hydrophobic stretch. The new N-terminal residue, usually Phe, is methylated. Separate domains of the prepilin peptidase appear responsible for cleavage and methylation. Proteins with this N-terminal region include type IV pilins and other components of pilus biogenesis, competence proteins, and type II secretion proteins. Typically several proteins in a single operon have this N-terminal domain. The N-terminal cleavage and methylation site is described by PROSITE motif PS00409 as [KRHEQSTAG]-G-[FYLIVM]-[ST]-[LT]-[LIVP]-E-[LIVMFWSTAG](14). [Cell envelope, Surface structures, Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274182 [Multi-domain]  Cd Length: 24  Bit Score: 39.60  E-value: 3.26e-05
                          10        20
                  ....*....|....*....|....
gi 1893778545   5 HQGFTLLELLTVIAVVAILFSITV 28
Cdd:TIGR02532   1 QRGFTLIELLVVLAILGILALIAL 24
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 2-28 4.07e-05

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 39.28  E-value: 4.07e-05
                          10        20
                  ....*....|....*....|....*..
gi 1893778545   2 KRNHQGFTLLELLTVIAVVAILFSITV 28
Cdd:pfam07963   1 MRKQRGFTLIELLVALAILAILLAAAL 27
PRK10574 PRK10574
putative major pilin subunit; Provisional
 4-30 1.78e-04

putative major pilin subunit; Provisional


Pssm-ID: 236718 [Multi-domain]  Cd Length: 146  Bit Score: 40.40  E-value: 1.78e-04
                          10        20
                  ....*....|....*....|....*..
gi 1893778545   4 NHQGFTLLELLTVIAVVAILFSITVVA 30
Cdd:PRK10574    3 KQRGFTLIELMVVIAIIAILSAIGIPA 29
PilV COG4967
Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];
1-57 6.04e-04

Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];


Pssm-ID: 443993 [Multi-domain]  Cd Length: 86  Bit Score: 37.66  E-value: 6.04e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1893778545   1 MKRNHQGFTLLELLtvIAVVaiLFSITVVAVGKVreSANTTKCASNLRSLGQAW-LAY 57
Cdd:COG4967     6 RRRRQRGFTLIEVL--VALV--ILSIGLLGLAGL--QAASLRSSQDARQRTQAAlLAQ 57
PulJ COG4795
Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and ...
 1-81 1.61e-03

Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 443823 [Multi-domain]  Cd Length: 118  Bit Score: 37.30  E-value: 1.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1893778545   1 MKRNHQGFTLLELLTVIAVVAILFSITVVAVGKV-RESANTTKCASNLRSLGQAWLAYGNEHQGAsLPYRNPDGGSTSWM 79
Cdd:COG4795     4 ARRRQRGFTLLELLVALAIFALLLLAAYRGLDSVlRSRERLEQQAERLQELQRALALLERDLRQA-GPRPDEGGDPEPAL 82


                  ..
gi 1893778545  80 LQ 81
Cdd:COG4795    83 SG 84
typeII_sec_gspG TIGR01710
type II secretion system protein G; This model represents GspG, protein G of the main terminal ...
 6-73 2.54e-03

type II secretion system protein G; This model represents GspG, protein G of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 130771 [Multi-domain]  Cd Length: 134  Bit Score: 37.02  E-value: 2.54e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1893778545   6 QGFTLLELLTVIAVVAILFSITVVAVGKVRESANTTKCASNLRSLGQAWL-------AYGNEHQGASLPYRNPDG 73
Cdd:TIGR01710   1 RGFTLLEIMVVLVILGLLAALVAPKLFSQADKAKAQVAKAQIKALKNALDmyrldngRYPTEEQGLAALVTKPSG 75
TIGR02596 TIGR02596
Verru_Chthon cassette protein D; This model describes a nearly twenty member protein family in ...
 8-47 3.46e-03

Verru_Chthon cassette protein D; This model describes a nearly twenty member protein family in Verrucomicrobium spinosum and a somewhat smaller paralogous family in Chthoniobacter flavus. All members share a type IV pilin-like N-terminal leader sequence (TIGR02532). These proteins occur in the four-gene Verru_Chthon cassette, in which two other genes likewise encode a cleavage/methylation domain. Most of these cassettes occur next to an unusually large PEP-CTERM protein with an autotransporter domain. [Cell envelope, Surface structures]


Pssm-ID: 274219 [Multi-domain]  Cd Length: 195  Bit Score: 37.45  E-value: 3.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1893778545   8 FTLLELLTVIAVVAILFSITVVAVGKVRESANTTKCASNL 47
Cdd:TIGR02596   1 FTLVELLVVIAIAALLMALSTPVVNQVLAAQQLGSSATRL 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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