NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1896016896|ref|WP_186421951|]
View 

DUF262 domain-containing protein [Oenococcus oeni]

Protein Classification

HNH endonuclease family protein( domain architecture ID 12545973)

HNH endonuclease family protein contains an HNH endonuclease signature motif and may catalyze the hydrolysis of DNA; also contains an N-terminal DUF262 domain

Gene Ontology:  GO:0003676|GO:0008270|GO:0004519

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DUF262 pfam03235
Protein of unknown function DUF262;
25-90 7.20e-15

Protein of unknown function DUF262;


:

Pssm-ID: 427209 [Multi-domain]  Cd Length: 78  Bit Score: 69.22  E-value: 7.20e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1896016896  25 KGLFGLSGKLTIqPEYQRNYIYADGKKDvACIDSMLKGYPLGLIYFNKLSDDKLEVLDGQQRITSI 90
Cdd:pfam03235   2 LPLLSDETIFDI-PDYQRLYVWRKKQVS-RLIEDLLYGYPIGSIVLAEDEDGTYEIIDGQQRLTTL 65
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
357-384 2.38e-10

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


:

Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 55.76  E-value: 2.38e-10
                          10        20
                  ....*....|....*....|....*...
gi 1896016896 357 DHIVPWSKGGKTERDNLQMLCKHHNSMK 384
Cdd:COG1403    37 DHIIPRSRGGTDTWENLVLLCRRCNRRK 64
 
Name Accession Description Interval E-value
DUF262 pfam03235
Protein of unknown function DUF262;
25-90 7.20e-15

Protein of unknown function DUF262;


Pssm-ID: 427209 [Multi-domain]  Cd Length: 78  Bit Score: 69.22  E-value: 7.20e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1896016896  25 KGLFGLSGKLTIqPEYQRNYIYADGKKDvACIDSMLKGYPLGLIYFNKLSDDKLEVLDGQQRITSI 90
Cdd:pfam03235   2 LPLLSDETIFDI-PDYQRLYVWRKKQVS-RLIEDLLYGYPIGSIVLAEDEDGTYEIIDGQQRLTTL 65
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
357-384 2.38e-10

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 55.76  E-value: 2.38e-10
                          10        20
                  ....*....|....*....|....*...
gi 1896016896 357 DHIVPWSKGGKTERDNLQMLCKHHNSMK 384
Cdd:COG1403    37 DHIIPRSRGGTDTWENLVLLCRRCNRRK 64
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 333-385 2.64e-09

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 52.86  E-value: 2.64e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1896016896 333 CPLCNTDTEYEHTTKiwdlkdmagDHIVPWSKGGKTERDNLQMLCKHHNSMKS 385
Cdd:cd00085    14 CPYCGKPGGTEGLEV---------DHIIPLSDGGNNDLDNLVLLCRKCHRKKH 57
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 356-386 1.02e-08

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 50.81  E-value: 1.02e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1896016896 356 GDHIVPWSKGGKTERDNLQMLCKHHNSMKSN 386
Cdd:pfam01844  16 VDHIIPLSDGGADDIENLILLCPSCHNKKHN 46
GmrSD COG1479
DNAse/DNA nickase specific for phosphorothioated or glycosylated phage DNA, GmrSD/DndB/SspE ...
 25-90 9.35e-07

DNAse/DNA nickase specific for phosphorothioated or glycosylated phage DNA, GmrSD/DndB/SspE family, contains DUF262 and HNH nuclease domains [Defense mechanisms];


Pssm-ID: 441088 [Multi-domain]  Cd Length: 544  Bit Score: 50.82  E-value: 9.35e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1896016896  25 KGLFGLSGKLTIqPEYQRNYIYadGKKDV-ACIDSMLKG-------YPLGLIYFNK-----LSDDKLEVLDGQQRITSI 90
Cdd:COG1479     9 GELLSGNGRFVI-PDYQRPYVW--TEEQVeDLLDDILRGfenndseYFLGSIVLWEtdnetAGVGKYEVIDGQQRLTTL 84
HNHc smart00507
HNH nucleases;
357-382 1.22e-06

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 45.14  E-value: 1.22e-06
                           10        20
                   ....*....|....*....|....*.
gi 1896016896  357 DHIVPWSKGGKTERDNLQMLCKHHNS 382
Cdd:smart00507  27 DHIIPLSDGGNDDLDNLVLLCPKCHI 52
 
Name Accession Description Interval E-value
DUF262 pfam03235
Protein of unknown function DUF262;
25-90 7.20e-15

Protein of unknown function DUF262;


Pssm-ID: 427209 [Multi-domain]  Cd Length: 78  Bit Score: 69.22  E-value: 7.20e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1896016896  25 KGLFGLSGKLTIqPEYQRNYIYADGKKDvACIDSMLKGYPLGLIYFNKLSDDKLEVLDGQQRITSI 90
Cdd:pfam03235   2 LPLLSDETIFDI-PDYQRLYVWRKKQVS-RLIEDLLYGYPIGSIVLAEDEDGTYEIIDGQQRLTTL 65
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
357-384 2.38e-10

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 55.76  E-value: 2.38e-10
                          10        20
                  ....*....|....*....|....*...
gi 1896016896 357 DHIVPWSKGGKTERDNLQMLCKHHNSMK 384
Cdd:COG1403    37 DHIIPRSRGGTDTWENLVLLCRRCNRRK 64
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 333-385 2.64e-09

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 52.86  E-value: 2.64e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1896016896 333 CPLCNTDTEYEHTTKiwdlkdmagDHIVPWSKGGKTERDNLQMLCKHHNSMKS 385
Cdd:cd00085    14 CPYCGKPGGTEGLEV---------DHIIPLSDGGNNDLDNLVLLCRKCHRKKH 57
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 356-386 1.02e-08

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 50.81  E-value: 1.02e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1896016896 356 GDHIVPWSKGGKTERDNLQMLCKHHNSMKSN 386
Cdd:pfam01844  16 VDHIIPLSDGGADDIENLILLCPSCHNKKHN 46
GmrSD COG1479
DNAse/DNA nickase specific for phosphorothioated or glycosylated phage DNA, GmrSD/DndB/SspE ...
 25-90 9.35e-07

DNAse/DNA nickase specific for phosphorothioated or glycosylated phage DNA, GmrSD/DndB/SspE family, contains DUF262 and HNH nuclease domains [Defense mechanisms];


Pssm-ID: 441088 [Multi-domain]  Cd Length: 544  Bit Score: 50.82  E-value: 9.35e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1896016896  25 KGLFGLSGKLTIqPEYQRNYIYadGKKDV-ACIDSMLKG-------YPLGLIYFNK-----LSDDKLEVLDGQQRITSI 90
Cdd:COG1479     9 GELLSGNGRFVI-PDYQRPYVW--TEEQVeDLLDDILRGfenndseYFLGSIVLWEtdnetAGVGKYEVIDGQQRLTTL 84
HNHc smart00507
HNH nucleases;
357-382 1.22e-06

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 45.14  E-value: 1.22e-06
                           10        20
                   ....*....|....*....|....*.
gi 1896016896  357 DHIVPWSKGGKTERDNLQMLCKHHNS 382
Cdd:smart00507  27 DHIIPLSDGGNDDLDNLVLLCPKCHI 52
HNH_5 pfam14279
HNH endonuclease; This domain is related to other HNH domain families such as pfam01844. ...
 333-384 2.10e-04

HNH endonuclease; This domain is related to other HNH domain families such as pfam01844. Suggesting that these proteins have a nucleic acid cleaving function.


Pssm-ID: 464124 [Multi-domain]  Cd Length: 56  Bit Score: 38.86  E-value: 2.10e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1896016896 333 CPLCNtdteyehttKIWDLKDMAGDHIVPWSKGGKTERDNLQMLCKHHNSMK 384
Cdd:pfam14279   1 CIYCG---------KEFPEKNLTIEHIIPESLGGKNKISNLQTLCKKCNSKK 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH