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Conserved domains on  [gi|1896435316|ref|WP_186750385|]
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aspartate:alanine exchanger family transporter [Corynebacterium canis]

Protein Classification

aspartate:alanine exchanger family transporter( domain architecture ID 11459491)

aspartate:alanine exchanger (AAEx) family transporter similar to transport protein YbjL

TCDB:  2.A.81

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 1-538 0e+00

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


:

Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 564.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316   1 MHLLVENKLLALLVIMSLGLLIGRIKIAGFRLGVAAVLFVGLGFATLEPDITLPSIVFIIGLSMFVYTIGLEAGPGFFQS 80
Cdd:COG2985     4 FELLVANPELALFLVIALGYLLGKIKIGGFSLGVAGVLFVGLLIGHFGVTLHIPHFVKSLGLALFVYAIGLQVGPGFFAS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316  81 LRTTGIRHNIFGLLMVVVITGVSYALIKAFNIDSPSGAGMFTGALTNTPAMAAVVDTLPALigsdSDTKAQLELPVVAYS 160
Cdd:COG2985    84 LKRDGLKLNLLAVVVVVLGLLVALALAKLFGLDPGLAAGLFAGALTNTPALGAAQDALGKL----GLSKQLSANPAVGYA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 161 LAYPIGVLGVIISVAVLAKVFRIDHDQEARDA----GVAIQELLTRRIRVTKEGL--PSVTTMPHRFDLEIIISRIEHSG 234
Cdd:COG2985   160 VAYPFGVIGIILFVALLPKLFRIDLDAEAKKLeageGSAYPPLVTRAYRVTNPNLvgKTVAELEALLGTRVVISRIRRGG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 235 KLFLPEPGDHVDPGDIISVVGTEEEVNKAQELIGEFLPGDPTHDEGLDYRRIFVSTTEMVGIPLRKLRPRLDH-MLVTRV 313
Cdd:COG2985   240 EIIVPTPDTVLQEGDIVLVVGTREALEAAEALLGEEVDDSELLDSDLDVRRIVVTNKEVAGKTLGELNLRNRFgVVITRV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 314 RRGDADMVATPDTILQLGDRVRVVAPHESIDRATRLFGDSYKRISDINLLPLLLGMSVGVLIGMIPIPLPGGTALKLGSA 393
Cdd:COG2985   320 RRGGVELPATPDTVLQLGDRLTVVGPKEDVERVAKLLGNSERKLSETDLLPLGLGIVLGLLLGSIPIPLPGIPPLSLGLA 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 394 GGPLVVSLILGAVGRTGPVVWQVPYGANLALRQLGITLFLAGIGTTAGAGFGKALADpRSLTILAVGAAITMIFSLLTLI 473
Cdd:COG2985   400 GGPLIVGLLLGRLGRTGPLVGYMPPSANLLLRELGLALFLAVVGLSAGPGFVETLQE-SGLLLFLLGALVTLVPLLVVLL 478

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1896435316 474 IGYKFMKIPFGQVSGILAGMQTHPAVLSYVSDQTKNELPSIGYTTVYPMAMVAKIVSAQVLLFLL 538
Cdd:COG2985   479 VGRYVLKLNYLILLGALAGAMTSPPALAAANEAAGSDAPALGYATVYPLAMILLILLGQLLVLLL 543
 
Name Accession Description Interval E-value
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 1-538 0e+00

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 564.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316   1 MHLLVENKLLALLVIMSLGLLIGRIKIAGFRLGVAAVLFVGLGFATLEPDITLPSIVFIIGLSMFVYTIGLEAGPGFFQS 80
Cdd:COG2985     4 FELLVANPELALFLVIALGYLLGKIKIGGFSLGVAGVLFVGLLIGHFGVTLHIPHFVKSLGLALFVYAIGLQVGPGFFAS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316  81 LRTTGIRHNIFGLLMVVVITGVSYALIKAFNIDSPSGAGMFTGALTNTPAMAAVVDTLPALigsdSDTKAQLELPVVAYS 160
Cdd:COG2985    84 LKRDGLKLNLLAVVVVVLGLLVALALAKLFGLDPGLAAGLFAGALTNTPALGAAQDALGKL----GLSKQLSANPAVGYA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 161 LAYPIGVLGVIISVAVLAKVFRIDHDQEARDA----GVAIQELLTRRIRVTKEGL--PSVTTMPHRFDLEIIISRIEHSG 234
Cdd:COG2985   160 VAYPFGVIGIILFVALLPKLFRIDLDAEAKKLeageGSAYPPLVTRAYRVTNPNLvgKTVAELEALLGTRVVISRIRRGG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 235 KLFLPEPGDHVDPGDIISVVGTEEEVNKAQELIGEFLPGDPTHDEGLDYRRIFVSTTEMVGIPLRKLRPRLDH-MLVTRV 313
Cdd:COG2985   240 EIIVPTPDTVLQEGDIVLVVGTREALEAAEALLGEEVDDSELLDSDLDVRRIVVTNKEVAGKTLGELNLRNRFgVVITRV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 314 RRGDADMVATPDTILQLGDRVRVVAPHESIDRATRLFGDSYKRISDINLLPLLLGMSVGVLIGMIPIPLPGGTALKLGSA 393
Cdd:COG2985   320 RRGGVELPATPDTVLQLGDRLTVVGPKEDVERVAKLLGNSERKLSETDLLPLGLGIVLGLLLGSIPIPLPGIPPLSLGLA 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 394 GGPLVVSLILGAVGRTGPVVWQVPYGANLALRQLGITLFLAGIGTTAGAGFGKALADpRSLTILAVGAAITMIFSLLTLI 473
Cdd:COG2985   400 GGPLIVGLLLGRLGRTGPLVGYMPPSANLLLRELGLALFLAVVGLSAGPGFVETLQE-SGLLLFLLGALVTLVPLLVVLL 478

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1896435316 474 IGYKFMKIPFGQVSGILAGMQTHPAVLSYVSDQTKNELPSIGYTTVYPMAMVAKIVSAQVLLFLL 538
Cdd:COG2985   479 VGRYVLKLNYLILLGALAGAMTSPPALAAANEAAGSDAPALGYATVYPLAMILLILLGQLLVLLL 543
PRK03818 PRK03818
putative transporter; Validated
 9-538 2.26e-123

putative transporter; Validated


Pssm-ID: 179654 [Multi-domain]  Cd Length: 552  Bit Score: 373.04  E-value: 2.26e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316   9 LLALLVImsLGLLIGRIKIAGFRLGVAAVLFVGL--GFATLEPDITLPSIV--FI--IGLSMFVYTIGLEAGPGFFQSLR 82
Cdd:PRK03818   10 ILALVAV--VGLWIGNIKIRGVGLGIGGVLFGGIivGHFVSQFGLTLDSDMlhFIqeFGLILFVYTIGIQVGPGFFSSLR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316  83 TTGIRHNIFGLLMVVVITGVSYALIKAFNIDSPSGAGMFTGALTNTPAMAAVVDTLPALiGSDSDTKAQLELpvvAYSLA 162
Cdd:PRK03818   88 KSGLRLNLFAVLIVILGGLVTAILHKLFGIPLPVMLGIFSGAVTNTPALGAGQQILRDL-GTPGDLVDQMGM---GYAMA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 163 YPIGVLGVIISVAVLAKVFRIDHDQEARDA----GVAIQELLTRRIRVTKEGL--PSVTTMPHRFDLEIIISRIEHSGKL 236
Cdd:PRK03818  164 YPFGICGILLSMWLIRLIFRINVDKEAQEFesssGNGHELLQTINIRVENPNLhgKAIKDVPILNGDKFVCSRLKRGDTL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 237 FLPEPGDHVDPGDIISVVGTEEEVNKAQELIGEFLPGD-PTHDEGLDYRRIFVSTTEMVGIPLRKLRPRLDH-MLVTRVR 314
Cdd:PRK03818  244 MVPSPDTIIQLGDLLHLVGQPEDLHKAQLVIGEEVDTSlSTRGTDLRSERVVVTNEKVLGKKLRDLHLKNKYgVVISRLN 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 315 RGDADMVATPDTILQLGDRVRVVAPHESIDRATRLFGDSYKRISDINLLPLLLGMSVGVLIGMIPIPLPG-GTALKLGSA 393
Cdd:PRK03818  324 RAGVELVASPDLSLQFGDILNLVGRPEAIDAVANVLGNAQQKLQQVQMLPVFIGIGLGVLLGSIPFFIPGfPAALKLGLA 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 394 GGPLVVSLILGAVGRTGPVVWQVPYGANLALRQLGITLFLAGIGTTAGAGFGKALADPRSLTILAVGAAITMIFSLLTLI 473
Cdd:PRK03818  404 GGPLIVALILGRIGSIGKLYWFMPPSANLALRELGIVLFLAVVGLKSGGDFVDTLVNGEGLSWIGYGFLITAVPLLIVGI 483

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1896435316 474 IGYKFMKIPFGQVSGILAGMQTHPAVLSYVSDQT-KNELPSIGYTTVYPMAMVAKIVSAQVLLFLL 538
Cdd:PRK03818  484 LARMLAKMNYLTLCGMLAGSMTDPPALAFANNLHpTSGAAALSYATVYPLVMFLRIITPQLLAVLF 549
YidE_YbjL_dupl TIGR01625
AspT/YidE/YbjL antiporter duplication domain; This model represents a domain that is ...
 369-522 2.89e-41

AspT/YidE/YbjL antiporter duplication domain; This model represents a domain that is duplicated the aspartate-alanine antiporter AspT, as well as HI0035 of Haemophilus influenzae, YidE and YbjL of E. coli, and a number of other known or putative transporters. Member proteins may have 0, 1, or 2 copies of TrkA potassium uptake domain pfam02080 between the duplications. The domain contains several apparent transmembrane regions and is proposed here to act in transport. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 130686 [Multi-domain]  Cd Length: 154  Bit Score: 145.55  E-value: 2.89e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 369 MSVGVLIGMIPIPLPGgTALKLGSAGGPLVVSLILGAVGRTGPVVWQVPYGANLALRQLGITLFLAGIGTTAGAGFGKAL 448
Cdd:TIGR01625   1 LALGLLLGKIPIGLPG-FSIKLGNAGGVLFVGLLLGHFGATGPLTWYIPFSANLFIREFGLMLFLYGVGLSAGPGFFSSL 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1896435316 449 ADPRSLTILAVGAAITMIFSLLTLIIGYKFMKIPFGQVSGILAGMQTHPAVLSYVSDQTK-NELPSIGYTTVYPM 522
Cdd:TIGR01625  80 KDGGGLLRINGGALITVVPTLLVAVALIKLLRINYALTAGMLAGATTNTPALDAANDTLRtSDLPALGYATVYPL 154
Asp-Al_Ex pfam06826
Predicted Permease Membrane Region; This family represents five transmembrane helices that are ...
 11-179 1.51e-35

Predicted Permease Membrane Region; This family represents five transmembrane helices that are normally found flanking (five either side) a pair of pfam02080 domains. This suggests that the paired regions form a ten helical structure, probably forming the pore, whereas the pfam02080) binds a ligand for export or regulation of the pore. Swiss:Q8L3K8 is described as a aspartate-alanine antiporter. In conjunction with Swiss:Q8L3K9 it forms a 'proton motive metabolic cycle catalyzed by an aspartate-alanine exchange'. The general conservation of domain architecture in this family suggests that they are functional orthologues.


Pssm-ID: 284291 [Multi-domain]  Cd Length: 167  Bit Score: 130.77  E-value: 1.51e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316  11 ALLVIMSLGLLIGRIKIA-GFRLGVA-AVLFVGLGFATLE------PDITLPSIVFIIGLSMFVYTIGLEAGPGFFQSLR 82
Cdd:pfam06826   1 ALFLGIALGLLLGRIKISgGFSLGVAgGVLIVGLLLGHFGstgptfMPISALSFLRELGLALFLAAVGLSAGPGFFSSLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316  83 TTGIRHNIFGLLMVVVITGVSYALIK-AFNIDSPSGAGMFTGALTNTPAMAAVVDTLpaligsdsdtkAQLELPVVAYSL 161
Cdd:pfam06826  81 KDGLLLIGLALLVTVVPLLLALVLGKyVLKLDPGLLAGLLAGALTSTPALGAANDAL-----------AGSDIPALGYAV 149

                         170
                  ....*....|....*...
gi 1896435316 162 AYPIGVLGVIISVAVLAK 179
Cdd:pfam06826 150 TYPFGVVGLILAGQVLAK 167
 
Name Accession Description Interval E-value
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 1-538 0e+00

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 564.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316   1 MHLLVENKLLALLVIMSLGLLIGRIKIAGFRLGVAAVLFVGLGFATLEPDITLPSIVFIIGLSMFVYTIGLEAGPGFFQS 80
Cdd:COG2985     4 FELLVANPELALFLVIALGYLLGKIKIGGFSLGVAGVLFVGLLIGHFGVTLHIPHFVKSLGLALFVYAIGLQVGPGFFAS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316  81 LRTTGIRHNIFGLLMVVVITGVSYALIKAFNIDSPSGAGMFTGALTNTPAMAAVVDTLPALigsdSDTKAQLELPVVAYS 160
Cdd:COG2985    84 LKRDGLKLNLLAVVVVVLGLLVALALAKLFGLDPGLAAGLFAGALTNTPALGAAQDALGKL----GLSKQLSANPAVGYA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 161 LAYPIGVLGVIISVAVLAKVFRIDHDQEARDA----GVAIQELLTRRIRVTKEGL--PSVTTMPHRFDLEIIISRIEHSG 234
Cdd:COG2985   160 VAYPFGVIGIILFVALLPKLFRIDLDAEAKKLeageGSAYPPLVTRAYRVTNPNLvgKTVAELEALLGTRVVISRIRRGG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 235 KLFLPEPGDHVDPGDIISVVGTEEEVNKAQELIGEFLPGDPTHDEGLDYRRIFVSTTEMVGIPLRKLRPRLDH-MLVTRV 313
Cdd:COG2985   240 EIIVPTPDTVLQEGDIVLVVGTREALEAAEALLGEEVDDSELLDSDLDVRRIVVTNKEVAGKTLGELNLRNRFgVVITRV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 314 RRGDADMVATPDTILQLGDRVRVVAPHESIDRATRLFGDSYKRISDINLLPLLLGMSVGVLIGMIPIPLPGGTALKLGSA 393
Cdd:COG2985   320 RRGGVELPATPDTVLQLGDRLTVVGPKEDVERVAKLLGNSERKLSETDLLPLGLGIVLGLLLGSIPIPLPGIPPLSLGLA 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 394 GGPLVVSLILGAVGRTGPVVWQVPYGANLALRQLGITLFLAGIGTTAGAGFGKALADpRSLTILAVGAAITMIFSLLTLI 473
Cdd:COG2985   400 GGPLIVGLLLGRLGRTGPLVGYMPPSANLLLRELGLALFLAVVGLSAGPGFVETLQE-SGLLLFLLGALVTLVPLLVVLL 478

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1896435316 474 IGYKFMKIPFGQVSGILAGMQTHPAVLSYVSDQTKNELPSIGYTTVYPMAMVAKIVSAQVLLFLL 538
Cdd:COG2985   479 VGRYVLKLNYLILLGALAGAMTSPPALAAANEAAGSDAPALGYATVYPLAMILLILLGQLLVLLL 543
PRK03818 PRK03818
putative transporter; Validated
 9-538 2.26e-123

putative transporter; Validated


Pssm-ID: 179654 [Multi-domain]  Cd Length: 552  Bit Score: 373.04  E-value: 2.26e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316   9 LLALLVImsLGLLIGRIKIAGFRLGVAAVLFVGL--GFATLEPDITLPSIV--FI--IGLSMFVYTIGLEAGPGFFQSLR 82
Cdd:PRK03818   10 ILALVAV--VGLWIGNIKIRGVGLGIGGVLFGGIivGHFVSQFGLTLDSDMlhFIqeFGLILFVYTIGIQVGPGFFSSLR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316  83 TTGIRHNIFGLLMVVVITGVSYALIKAFNIDSPSGAGMFTGALTNTPAMAAVVDTLPALiGSDSDTKAQLELpvvAYSLA 162
Cdd:PRK03818   88 KSGLRLNLFAVLIVILGGLVTAILHKLFGIPLPVMLGIFSGAVTNTPALGAGQQILRDL-GTPGDLVDQMGM---GYAMA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 163 YPIGVLGVIISVAVLAKVFRIDHDQEARDA----GVAIQELLTRRIRVTKEGL--PSVTTMPHRFDLEIIISRIEHSGKL 236
Cdd:PRK03818  164 YPFGICGILLSMWLIRLIFRINVDKEAQEFesssGNGHELLQTINIRVENPNLhgKAIKDVPILNGDKFVCSRLKRGDTL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 237 FLPEPGDHVDPGDIISVVGTEEEVNKAQELIGEFLPGD-PTHDEGLDYRRIFVSTTEMVGIPLRKLRPRLDH-MLVTRVR 314
Cdd:PRK03818  244 MVPSPDTIIQLGDLLHLVGQPEDLHKAQLVIGEEVDTSlSTRGTDLRSERVVVTNEKVLGKKLRDLHLKNKYgVVISRLN 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 315 RGDADMVATPDTILQLGDRVRVVAPHESIDRATRLFGDSYKRISDINLLPLLLGMSVGVLIGMIPIPLPG-GTALKLGSA 393
Cdd:PRK03818  324 RAGVELVASPDLSLQFGDILNLVGRPEAIDAVANVLGNAQQKLQQVQMLPVFIGIGLGVLLGSIPFFIPGfPAALKLGLA 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 394 GGPLVVSLILGAVGRTGPVVWQVPYGANLALRQLGITLFLAGIGTTAGAGFGKALADPRSLTILAVGAAITMIFSLLTLI 473
Cdd:PRK03818  404 GGPLIVALILGRIGSIGKLYWFMPPSANLALRELGIVLFLAVVGLKSGGDFVDTLVNGEGLSWIGYGFLITAVPLLIVGI 483

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1896435316 474 IGYKFMKIPFGQVSGILAGMQTHPAVLSYVSDQT-KNELPSIGYTTVYPMAMVAKIVSAQVLLFLL 538
Cdd:PRK03818  484 LARMLAKMNYLTLCGMLAGSMTDPPALAFANNLHpTSGAAALSYATVYPLVMFLRIITPQLLAVLF 549
YidE_YbjL_dupl TIGR01625
AspT/YidE/YbjL antiporter duplication domain; This model represents a domain that is ...
 369-522 2.89e-41

AspT/YidE/YbjL antiporter duplication domain; This model represents a domain that is duplicated the aspartate-alanine antiporter AspT, as well as HI0035 of Haemophilus influenzae, YidE and YbjL of E. coli, and a number of other known or putative transporters. Member proteins may have 0, 1, or 2 copies of TrkA potassium uptake domain pfam02080 between the duplications. The domain contains several apparent transmembrane regions and is proposed here to act in transport. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 130686 [Multi-domain]  Cd Length: 154  Bit Score: 145.55  E-value: 2.89e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 369 MSVGVLIGMIPIPLPGgTALKLGSAGGPLVVSLILGAVGRTGPVVWQVPYGANLALRQLGITLFLAGIGTTAGAGFGKAL 448
Cdd:TIGR01625   1 LALGLLLGKIPIGLPG-FSIKLGNAGGVLFVGLLLGHFGATGPLTWYIPFSANLFIREFGLMLFLYGVGLSAGPGFFSSL 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1896435316 449 ADPRSLTILAVGAAITMIFSLLTLIIGYKFMKIPFGQVSGILAGMQTHPAVLSYVSDQTK-NELPSIGYTTVYPM 522
Cdd:TIGR01625  80 KDGGGLLRINGGALITVVPTLLVAVALIKLLRINYALTAGMLAGATTNTPALDAANDTLRtSDLPALGYATVYPL 154
PRK04972 PRK04972
putative transporter; Provisional
 2-525 1.23e-35

putative transporter; Provisional


Pssm-ID: 179905 [Multi-domain]  Cd Length: 558  Bit Score: 140.24  E-value: 1.23e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316   2 HLLVENKLLALLVIMSLGLLIGRIKIAGFRLGVA-AVLFVGLGFATLEPDITLPSIVfiIGLSMFVYTIGLEAGPGFFQS 80
Cdd:PRK04972    7 DLLNGNYILLLFVVLALGLCLGKLRLGSIQLGNSiGVLVVSLLLGQQHFSINTDALN--LGFMLFIFCVGVEAGPNFFSI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316  81 LRTTGIRHNIFGLLMVVVITGVSYALIKAFNIDSPSGAGMFTGALTNTPAMAAVVDTLPALIGSDSDTKAQLELPVVAYS 160
Cdd:PRK04972   85 FFRDGKNYLMLALVMVGSALVIALGLGKLFGWDIGLTAGMLAGSMTSTPVLVGAGDTLRHSGAESRQLSLALDNLSLGYA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 161 LAYPIGVLGVIISVAVLAKVFRID----HDQEARDAGVAIQEL------LTRRIRVTKEgLPSVTTMPHRFDLEI----- 225
Cdd:PRK04972  165 LTYLIGLVSLIVGARYLPKLQHQDlqtsAQQIARERGLDTDAQrkvylpVIRAYRVGPE-LVAWTDGKNLRELGIyrqtg 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 226 -IISRIEHSGKLFLPEpGDHV-DPGDIISVVGTEEEVNKaqeLIGEFLPGDPTHDEG-LDYR----RIFVSTTEMVGIPL 298
Cdd:PRK04972  244 cYIERIRRNGILANPD-GDAVlQMGDEIALVGYPDAHAR---LDPSFRNGKEVFDRDlLDMRivteEIVVKNHNAVGKRL 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 299 RKLRPRLDHMLVTRVRRGDADMVATPDTILQLGDRVRVVAPHESIDR-ATRL-FGDSYKRISDinLLPLLLGMSVGVLIG 376
Cdd:PRK04972  320 SQLKLTDHGCFLNRVIRSQIEMPIDDNVVLNKGDVLQVSGDARRVKTiADRIgFISIHSQVTD--LLAFCAFFIIGLMIG 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 377 MIPIPLpGGTALKLGSAGGPLVVSLILGAVGRTGPVVWQVPYGANLALRQLGITLFLAGIGTTAGAGFGKALADPRSLTI 456
Cdd:PRK04972  398 MITFQF-SNFSFGIGNAAGLLFAGIMLGFLRANHPTFGYIPQGALNMVKEFGLMVFMAGVGLSAGSGINNGLGAVGGQML 476

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1896435316 457 LAvgaaiTMIFSLLTLIIGYKF----MKIPFGQVSGILAGMQTHPAVLSYVSDQTKNELPSIGYTTVYPMAMV 525
Cdd:PRK04972  477 IA-----GLIVSLVPVVICFLFgayvLRMNRALLFGAIMGARTCAPAMEIISDTARSNIPALGYAGTYAIANV 544
Asp-Al_Ex pfam06826
Predicted Permease Membrane Region; This family represents five transmembrane helices that are ...
 11-179 1.51e-35

Predicted Permease Membrane Region; This family represents five transmembrane helices that are normally found flanking (five either side) a pair of pfam02080 domains. This suggests that the paired regions form a ten helical structure, probably forming the pore, whereas the pfam02080) binds a ligand for export or regulation of the pore. Swiss:Q8L3K8 is described as a aspartate-alanine antiporter. In conjunction with Swiss:Q8L3K9 it forms a 'proton motive metabolic cycle catalyzed by an aspartate-alanine exchange'. The general conservation of domain architecture in this family suggests that they are functional orthologues.


Pssm-ID: 284291 [Multi-domain]  Cd Length: 167  Bit Score: 130.77  E-value: 1.51e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316  11 ALLVIMSLGLLIGRIKIA-GFRLGVA-AVLFVGLGFATLE------PDITLPSIVFIIGLSMFVYTIGLEAGPGFFQSLR 82
Cdd:pfam06826   1 ALFLGIALGLLLGRIKISgGFSLGVAgGVLIVGLLLGHFGstgptfMPISALSFLRELGLALFLAAVGLSAGPGFFSSLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316  83 TTGIRHNIFGLLMVVVITGVSYALIK-AFNIDSPSGAGMFTGALTNTPAMAAVVDTLpaligsdsdtkAQLELPVVAYSL 161
Cdd:pfam06826  81 KDGLLLIGLALLVTVVPLLLALVLGKyVLKLDPGLLAGLLAGALTSTPALGAANDAL-----------AGSDIPALGYAV 149

                         170
                  ....*....|....*...
gi 1896435316 162 AYPIGVLGVIISVAVLAK 179
Cdd:pfam06826 150 TYPFGVVGLILAGQVLAK 167
Asp-Al_Ex pfam06826
Predicted Permease Membrane Region; This family represents five transmembrane helices that are ...
 364-535 4.89e-34

Predicted Permease Membrane Region; This family represents five transmembrane helices that are normally found flanking (five either side) a pair of pfam02080 domains. This suggests that the paired regions form a ten helical structure, probably forming the pore, whereas the pfam02080) binds a ligand for export or regulation of the pore. Swiss:Q8L3K8 is described as a aspartate-alanine antiporter. In conjunction with Swiss:Q8L3K9 it forms a 'proton motive metabolic cycle catalyzed by an aspartate-alanine exchange'. The general conservation of domain architecture in this family suggests that they are functional orthologues.


Pssm-ID: 284291 [Multi-domain]  Cd Length: 167  Bit Score: 126.53  E-value: 4.89e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 364 PLLLGMSVGVLIGMIPIPlpggTALKLGSAGGPLVVSLILGAVGRTGPVVwqVPYGANLALRQLGITLFLAGIGTTAGAG 443
Cdd:pfam06826   1 ALFLGIALGLLLGRIKIS----GGFSLGVAGGVLIVGLLLGHFGSTGPTF--MPISALSFLRELGLALFLAAVGLSAGPG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 444 FGKALADPrSLTILAVGAAITMIFSLLTLIIGYKFMKIPFGQVSGILAGMQTHPAVLSYVSDQ-TKNELPSIGYTTVYPM 522
Cdd:pfam06826  75 FFSSLKKD-GLLLIGLALLVTVVPLLLALVLGKYVLKLDPGLLAGLLAGALTSTPALGAANDAlAGSDIPALGYAVTYPF 153

                         170
                  ....*....|...
gi 1896435316 523 AMVAKIVSAQVLL 535
Cdd:pfam06826 154 GVVGLILAGQVLA 166
YidE_YbjL_dupl TIGR01625
AspT/YidE/YbjL antiporter duplication domain; This model represents a domain that is ...
 16-165 9.68e-25

AspT/YidE/YbjL antiporter duplication domain; This model represents a domain that is duplicated the aspartate-alanine antiporter AspT, as well as HI0035 of Haemophilus influenzae, YidE and YbjL of E. coli, and a number of other known or putative transporters. Member proteins may have 0, 1, or 2 copies of TrkA potassium uptake domain pfam02080 between the duplications. The domain contains several apparent transmembrane regions and is proposed here to act in transport. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 130686 [Multi-domain]  Cd Length: 154  Bit Score: 100.10  E-value: 9.68e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316  16 MSLGLLIGRIKI----AGFRLGVAA-VLFVGL--------GFATLEPDITLPSIVFIIGLSMFVYTIGLEAGPGFFQSLR 82
Cdd:TIGR01625   1 LALGLLLGKIPIglpgFSIKLGNAGgVLFVGLllghfgatGPLTWYIPFSANLFIREFGLMLFLYGVGLSAGPGFFSSLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316  83 TTG--IRHNIFGLLMVVVITGVSYALIKAFNIDSPSGAGMFTGALTNTPAMAAVVDTLPaligsdsdtkaQLELPVVAYS 160
Cdd:TIGR01625  81 DGGglLRINGGALITVVPTLLVAVALIKLLRINYALTAGMLAGATTNTPALDAANDTLR-----------TSDLPALGYA 149


                  ....*
gi 1896435316 161 LAYPI 165
Cdd:TIGR01625 150 TVYPL 154
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 283-350 9.27e-07

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 46.45  E-value: 9.27e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1896435316 283 YRRIFVSTTEMVGIPLRKLR-PRLDHMLVTRVRRGDADMVATPDTILQLGDRVRVVAPHESIDRATRLF 350
Cdd:pfam02080   2 VEVTVPENSPLVGKTLKELNlPERFGVRIVAIRRGGRLIIPSGDTVLEAGDRLLVIGTPDDLAALRELL 70
trkA PRK09496
Trk system potassium transporter TrkA;
293-360 2.35e-04

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 43.57  E-value: 2.35e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 293 MVGIPLRKLRPRL--DHMLVTRVRRGDADMVATPDTILQLGDRVRVVAPHESIDRATRLFGDSYKRISDI 360
Cdd:PRK09496  165 LVGKPLSDLREHFpdIDVRVVAIFRGGRLIIPRGDTVIEAGDEVYFIGAREHIRAVMSEFGRLEKPVKRV 234
PRK04972 PRK04972
putative transporter; Provisional
 362-534 4.64e-04

putative transporter; Provisional


Pssm-ID: 179905 [Multi-domain]  Cd Length: 558  Bit Score: 42.79  E-value: 4.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 362 LLPLLLGMSVGVLIGMIPIplpggTALKLGSAGGPLVVSLILGAVGrtgpvvwqvpYGANLALRQLGITLFLAGIGTTAG 441
Cdd:PRK04972   14 ILLLFVVLALGLCLGKLRL-----GSIQLGNSIGVLVVSLLLGQQH----------FSINTDALNLGFMLFIFCVGVEAG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1896435316 442 AG-FGKALADPRSLTILAVGAAITMIfsLLTLIIGyKFMKIPFGQVSGILAGMQTHPAVLSYVSDQTKNELP-------- 512
Cdd:PRK04972   79 PNfFSIFFRDGKNYLMLALVMVGSAL--VIALGLG-KLFGWDIGLTAGMLAGSMTSTPVLVGAGDTLRHSGAesrqlsla 155

                         170       180
                  ....*....|....*....|....*.
gi 1896435316 513 ----SIGYTTVYPMAMVAKIVSAQVL 534
Cdd:PRK04972  156 ldnlSLGYALTYLIGLVSLIVGARYL 181
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 217-267 2.20e-03

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 36.82  E-value: 2.20e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1896435316 217 MPHRFDleIIISRIEHSGKLFLPEPGDHVDPGDIISVVGTEEEVNKAQELI 267
Cdd:pfam02080  22 LPERFG--VRIVAIRRGGRLIIPSGDTVLEAGDRLLVIGTPDDLAALRELL 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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